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Brian Head

TitleAssociate Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address9500 Gilman Drive #9125
La Jolla CA 92093
Phone858-642-3051
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    Collapse Research 
    Collapse Research Activities and Funding
    Caveolin-mediated neuronal signaling in differentiated adult human neuronal stem cells and the aging brain
    VA I01BX003671Apr 1, 2017 - Mar 31, 2021
    Role: Principal Investigator
    Neuron-Targeted Caveolin-1 as a Therapy for Age-Related Neurodegeneration
    VA I01BX001225Apr 1, 2012 - Mar 31, 2015
    Role: Principal Investigator
    Neuronal-targeted caveolin-1 as a therapy for traumatic brain injury
    NIH/NINDS R01NS073653Dec 1, 2011 - Nov 30, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tonn Eisinger KR, Gross KS, Head BP, Mermelstein PG. Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females. Horm Behav. 2018 Mar 10. PMID: 29505763.
      View in: PubMed
    2. Takashima Y, Fannon MJ, Galinato MH, Steiner NL, An M, Zemljic-Harpf AE, Somkuwar SS, Head BP, Mandyam CD. Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct. 2018 Feb 13. PMID: 29441405.
      View in: PubMed
    3. Wang S, Head BP. Caveolin-1 in stroke neuropathology and neuroprotection: a novel molecular therapeutic target for ischemic-related injury. Curr Vasc Pharmacol. 2018 Feb 05. PMID: 29412114.
      View in: PubMed
    4. Schilling JM, Head BP, Patel HH. Caveolins as Regulators of Stress Adaptation. Mol Pharmacol. 2018 Apr; 93(4):277-285. PMID: 29358220.
      View in: PubMed
    5. Wang L, Jang G, Ban DK, Sant V, Seth J, Kazmi S, Patel N, Yang Q, Lee J, Janetanakit W, Wang S, Head BP, Glinsky G, Lal R. Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls: Nanoshuttles for targeted on-demand theranostics. Bone Res. 2017; 5:17051. PMID: 29285401.
      View in: PubMed
    6. Shahidi B, Shah SB, Esparza M, Head BP, Ward SR. Skeletal Muscle Atrophy and Degeneration in a Mouse Model of Traumatic Brain Injury. J Neurotrauma. 2018 Jan 15; 35(2):398-401. PMID: 28895461.
      View in: PubMed
    7. Schilling JM, Kassan A, Mandyam C, Pearn ML, Voong A, Grogman GG, Risbrough VB, Niesman IR, Patel HH, Patel PM, Head BP. Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice. Br J Anaesth. 2017 Sep 01; 119(3):465-471. PMID: 28969308.
      View in: PubMed
    8. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2017 Jul 31; 1-12. PMID: 28981594.
      View in: PubMed
    9. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 08; 31(8):3403-3411. PMID: 28450301.
      View in: PubMed
    10. Liu X, Wong SS, Taype CA, Kim J, Shentu TP, Espinoza CR, Finley JC, Bradley JE, Head BP, Patel HH, Mah EJ, Hagood JS. Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution. Lab Invest. 2017 03; 97(3):256-267. PMID: 28165468.
      View in: PubMed
    11. Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth DM, Patel PM, Patel HH, Head BP. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. J Neurophysiol. 2017 Jan 01; 117(1):436-444. PMID: 27832597.
      View in: PubMed
    12. Kassan A, Pham U, Nguyen Q, Reichelt ME, Cho E, Patel PM, Roth DM, Head BP, Patel HH. Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. Am J Physiol Cell Physiol. 2016 Dec 01; 311(6):C854-C865. PMID: 27707689.
      View in: PubMed
    13. Pearn ML, Niesman IR, Egawa J, Sawada A, Almenar-Queralt A, Shah SB, Duckworth JL, Head BP. Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics. Cell Mol Neurobiol. 2017 May; 37(4):571-585. PMID: 27383839.
      View in: PubMed
    14. Somkuwar SS, Fannon MJ, Head BP, Mandyam CD. Methamphetamine reduces expression of caveolin-1 in the dorsal striatum: Implication for dysregulation of neuronal function. Neuroscience. 2016 07 22; 328:147-56. PMID: 27138644; PMCID: PMC4891199 [Available on 07/22/17].
      View in: PubMed, PubMed Central
    15. Forati E, Sabouni A, Ray S, Head B, Schoen C, Sievenpiper D. Neurotransmitter Specific, Cellular-Resolution Functional Brain Mapping Using Receptor Coated Nanoparticles: Assessment of the Possibility. PLoS One. 2015; 10(12):e0145852. PMID: 26717196.
      View in: PubMed
    16. Egawa J, Pearn ML, Lemkuil BP, Patel PM, Head BP. Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function. J Physiol. 2016 08 15; 594(16):4565-79. PMID: 26332795; PMCID: PMC4983616 [Available on 08/15/17].
      View in: PubMed, PubMed Central
    17. Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2017 01 15; 81(2):101-110. PMID: 26592463.
      View in: PubMed
    18. Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth DM, Yue Y, Patel HH. Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent. Anesthesiology. 2014 Sep; 121(3):538-48. PMID: 24821070; PMCID: PMC4219636.
      View in: PubMed, PubMed Central
    19. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 01; 267:6-11. PMID: 24657594; PMCID: PMC4059187.
      View in: PubMed, PubMed Central
    20. Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, Cui W, Voong A, Krajewski S, Ali SS, Roth DM, Patel HH, Patel PM, Head BP. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014 Mar 03; 11:39. PMID: 24593993; PMCID: PMC3975903.
      View in: PubMed, PubMed Central
    21. Head BP, Patel HH, Insel PA. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochim Biophys Acta. 2014 Feb; 1838(2):532-45. PMID: 23899502; PMCID: PMC3867519.
      View in: PubMed, PubMed Central
    22. Niesman IR, Zemke N, Fridolfsson HN, Haushalter KJ, Levy K, Grove A, Schnoor R, Finley JC, Patel PM, Roth DM, Head BP, Patel HH. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia. Mol Cell Neurosci. 2013 Sep; 56:283-97. PMID: 23851187; PMCID: PMC3791173.
      View in: PubMed, PubMed Central
    23. Panneerselvam M, Ali SS, Finley JC, Kellerhals SE, Migita MY, Head BP, Patel PM, Roth DM, Patel HH. Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent. Mol Nutr Food Res. 2013 Jun; 57(6):1007-14. PMID: 23625721; PMCID: PMC3835714.
      View in: PubMed, PubMed Central
    24. Stary CM, Tsutsumi YM, Patel PM, Head BP, Patel HH, Roth DM. Caveolins: targeting pro-survival signaling in the heart and brain. Front Physiol. 2012; 3:393. PMID: 23060817; PMCID: PMC3464704.
      View in: PubMed, PubMed Central
    25. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. PMID: 22859372; PMCID: PMC4050367.
      View in: PubMed, PubMed Central
    26. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. PMID: 22198221; PMCID: PMC3275822.
      View in: PubMed, PubMed Central
    27. Krajewska M, You Z, Rong J, Kress C, Huang X, Yang J, Kyoda T, Leyva R, Banares S, Hu Y, Sze CH, Whalen MJ, Salmena L, Hakem R, Head BP, Reed JC, Krajewski S. Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. PLoS One. 2011; 6(9):e24341. PMID: 21957448.
      View in: PubMed
    28. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth DM, Patel HH. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011 Sep; 115(3):499-508. PMID: 21862885; PMCID: PMC3162469.
      View in: PubMed, PubMed Central
    29. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem. 2011 Sep 23; 286(38):33310-21. PMID: 21799010; PMCID: PMC3190943.
      View in: PubMed, PubMed Central
    30. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011 May 31; 57(22):2273-83. PMID: 21616289; PMCID: PMC3236642.
      View in: PubMed, PubMed Central
    31. Panneerselvam M, Patel PM, Roth DM, Kidd MW, Chin-Lee B, Head BP, Niesman IR, Inoue S, Patel HH, Davis DP. Role of decoy molecules in neuronal ischemic preconditioning. Life Sci. 2011 Apr 11; 88(15-16):670-4. PMID: 21315738; PMCID: PMC3070046.
      View in: PubMed, PubMed Central
    32. Lemkuil BP, Head BP, Pearn ML, Patel HH, Drummond JC, Patel PM. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology. 2011 Jan; 114(1):49-57. PMID: 21169791; PMCID: PMC3037980.
      View in: PubMed, PubMed Central
    33. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010 Dec 23; 5(12):e15697. PMID: 21203469; PMCID: PMC3009734.
      View in: PubMed, PubMed Central
    34. Panneerselvam M, Tsutsumi YM, Bonds JA, Horikawa YT, Saldana M, Dalton ND, Head BP, Patel PM, Roth DM, Patel HH. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1604-9. PMID: 20833967; PMCID: PMC2993198.
      View in: PubMed, PubMed Central
    35. Drummond JC, Head BP, Patel PM. Statins might contribute to postoperative delirium. Anesthesiology. 2010 Aug; 113(2):500-1. PMID: 20657207.
      View in: PubMed
    36. Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, Patel HH. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology. 2010 May; 112(5):1136-45. PMID: 20418694; PMCID: PMC2860616.
      View in: PubMed, PubMed Central
    37. Head BP, Patel HH, Niesman IR, Drummond JC, Roth DM, Patel PM. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology. 2009 Apr; 110(4):813-25. PMID: 19293698; PMCID: PMC2767332.
      View in: PubMed, PubMed Central
    38. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation. 2008 Nov 04; 118(19):1979-88. PMID: 18936328; PMCID: PMC2676165.
      View in: PubMed, PubMed Central
    39. Head BP, Patel P. Anesthetics and brain protection. Curr Opin Anaesthesiol. 2007 Oct; 20(5):395-9. PMID: 17873591.
      View in: PubMed
    40. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008 Mar; 22(3):828-40. PMID: 17905724.
      View in: PubMed
    41. Patel HH, Zhang S, Murray F, Suda RY, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JX, Insel PA. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 2007 Sep; 21(11):2970-9. PMID: 17470567.
      View in: PubMed
    42. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 2007 May; 21(7):1565-74. PMID: 17272740.
      View in: PubMed
    43. Head BP, Insel PA. Do caveolins regulate cells by actions outside of caveolae? Trends Cell Biol. 2007 Feb; 17(2):51-7. PMID: 17150359.
      View in: PubMed
    44. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 Sep 08; 281(36):26391-9. PMID: 16818493.
      View in: PubMed
    45. Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel PA. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. J Biol Chem. 2006 Jun 23; 281(25):17173-9. PMID: 16618703.
      View in: PubMed
    46. Tsutsumi YM, Patel HH, Lai NC, Takahashi T, Head BP, Roth DM. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. Anesthesiology. 2006 Mar; 104(3):495-502. PMID: 16508397.
      View in: PubMed
    47. Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H344-50. PMID: 16501018.
      View in: PubMed
    48. Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1131-4. PMID: 16246064.
      View in: PubMed
    49. Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem. 2005 Sep 02; 280(35):31036-44. PMID: 15961389.
      View in: PubMed
    50. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann N Y Acad Sci. 2005 Jun; 1047:166-72. PMID: 16093494.
      View in: PubMed
    51. Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Mol Pharmacol. 2002 Nov; 62(5):983-92. PMID: 12391260.
      View in: PubMed
    52. Regulation of cardiac function in the horn shark by changes in pericardial fluid volume mediated through the pericardioperitoneal canal. Fish Physiology and Biochemistry. 2001; 24:141-148.
    53. Lai NC, Roth DM, Gao MH, Fine S, Head BP, Zhu J, McKirnan MD, Kwong C, Dalton N, Urasawa K, Roth DA, Hammond HK. Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity. Circulation. 2000 Nov 07; 102(19):2396-401. PMID: 11067795.
      View in: PubMed
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