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Pei-An (Betty) Shih, MPM, PhD

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Phone858-534-6768
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    Collapse Research 
    Collapse Research Activities and Funding
    Solving EPHX2 and PUFA Interactions in Anorexia Nervosa
    NIH/NIMH R01MH106781Jun 21, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    NIH/NIDDK K01DK087813Jul 1, 2011 - Apr 30, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Apple AC, Schroeder MP, Ryals AJ, Wagner LI, Cella D, Shih P, Reilly J, Penedo FJ, Voss JL, Wang L. Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy. Neuroimage Clin. 2018; 20:110-118. PMID: 30094161.
      View in: PubMed
    2. Wang Y, Wang W, Sanidad KZ, Shih P, Zhao X, Zhang G. Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Rev. 2018 Jun 01. PMID: 29858741.
      View in: PubMed
    3. Yang J, Shih P. Fasting and postprandial soluble epoxide hydrolase-associated eicosanoids of remitted patients with eating disorder. Data Brief. 2018 Apr; 17:334-338. PMID: 29876402.
      View in: PubMed
    4. Shih P, Morisseau C, Le T, Woodside B, German JB. Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa. Prostaglandins Other Lipid Mediat. 2017 Nov; 133:11-19. PMID: 28873340.
      View in: PubMed
    5. Joseph J, Depp C, Shih P, Cadenhead KS, Schmid-Schönbein G. Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? Front Neurosci. 2017; 11:155. PMID: 28396623.
      View in: PubMed
    6. Apple AC, Ryals AJ, Alpert KI, Wagner LI, Shih P, Dokucu M, Cella D, Penedo FJ, Voss JL, Wang L. Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns. Neuroimage Clin. 2017; 14:685-691. PMID: 28377882.
      View in: PubMed
    7. Shih P. Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa. Prostaglandins Other Lipid Mediat. 2017 Sep; 132:69-76. PMID: 28232135.
      View in: PubMed
    8. Shih P, Woodside DB. Contemporary views on the genetics of anorexia nervosa. Eur Neuropsychopharmacol. 2016 Apr; 26(4):663-73. PMID: 26944296; PMCID: PMC4801707 [Available on 04/01/17].
    9. Shih P, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry. 2016 Apr; 21(4):537-46. PMID: 25824304; PMCID: PMC4591075.
    10. Johnson DC, Thom NJ, Stanley EA, Haase L, Simmons AN, Shih P, Thompson WK, Potterat EG, Minor TR, Paulus MP. Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment. Am J Psychiatry. 2014 Aug; 171(8):844-53. PMID: 24832476.
      View in: PubMed
    11. Rana BK, Darst BF, Bloss C, Shih P, Depp C, Nievergelt CM, Allison M, Parsons JK, Schork N, Jeste DV. Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. Am J Geriatr Psychiatry. 2014 Oct; 22(10):997-1006.e5. PMID: 24791650.
      View in: PubMed
    12. Marzola E, Nasser JA, Hashim SA, Shih P, Kaye WH. Nutritional rehabilitation in anorexia nervosa: review of the literature and implications for treatment. BMC Psychiatry. 2013 Nov 07; 13:290. PMID: 24200367; PMCID: PMC3829207.
    13. Scott-Van Zeeland AA, Bloss CS, Tewhey R, Bansal V, Torkamani A, Libiger O, Duvvuri V, Wineinger N, Galvez L, Darst BF, Smith EN, Carson A, Pham P, Phillips T, Villarasa N, Tisch R, Zhang G, Levy S, Murray S, Chen W, Srinivasan S, Berenson G, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB, Bulik CM, Keel P, Klump KL, Lilenfeld L, Plotnicov K, Topol EJ, Shih P, Magistretti P, Bergen AW, Berrettini W, Kaye W, Schork NJ. Evidence for the role of EPHX2 gene variants in anorexia nervosa. Mol Psychiatry. 2014 Jun; 19(6):724-32. PMID: 23999524; PMCID: PMC3852189.
    14. Wei Z, Zhang K, Wen G, Balasubramanian K, Shih P, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata SK, O'Connor DT. Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs. J Hypertens. 2013 Jan; 31(1):123-33. PMID: 23149563; PMCID: PMC3615981.
    15. Jin H, Shih P, Golshan S, Mudaliar S, Henry R, Glorioso DK, Arndt S, Kraemer HC, Jeste DV. Comparison of longer-term safety and effectiveness of 4 atypical antipsychotics in patients over age 40: a trial using equipoise-stratified randomization. J Clin Psychiatry. 2013 Jan; 74(1):10-8. PMID: 23218100.
      View in: PubMed
    16. Kang SW, Shih P, Mathew RO, Mahata M, Biswas N, Rao F, Yan L, Bouchard J, Malhotra R, Tolwani A, Khandrika S, Mehta RL, O'Connor DT. Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences. BMC Nephrol. 2011 Jun 16; 12:27. PMID: 21679467; PMCID: PMC3154145.
    17. Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih P, Rao F, O'Connor DT, Taylor P. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther. 2011 Jul; 338(1):125-33. PMID: 21493754; PMCID: PMC3126649.
    18. Shih P, O'Connor DT. Synergistic physician and patient behavioral interventions as management strategy for effective population-based hypertension control. Curr Hypertens Rep. 2010 Jun; 12(3):149-51. PMID: 20424947; PMCID: PMC2876256.
    19. Shih P, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199513.
      View in: PubMed
    20. Shih P, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab. 2009 Nov; 94(11):4557-66. PMID: 19820027; PMCID: PMC2775651.
    21. Shih P, Manzi S, Shaw P, Kenney M, Kao AH, Bontempo F, Barmada MM, Kammerer C, Kamboh MI. Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations. J Rheumatol. 2008 Nov; 35(11):2171-8. PMID: 18793001; PMCID: PMC2582591.
    22. O'Connor DT, Zhu G, Rao F, Taupenot L, Fung MM, Das M, Mahata SK, Mahata M, Wang L, Zhang K, Greenwood TA, Shih P, Cockburn MG, Ziegler MG, Stridsberg M, Martin NG, Whitfield JB. Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure. Circulation. 2008 Jul 15; 118(3):247-57. PMID: 18591442; PMCID: PMC2654229.
    23. Shih P, O'Connor DT. Hereditary determinants of human hypertension: strategies in the setting of genetic complexity. Hypertension. 2008 Jun; 51(6):1456-64. PMID: 18413494; PMCID: PMC2587105.
    24. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih P, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
      View in: PubMed
    25. Calano SJ, Shih P, Liu CC, Kao AH, Navratil JS, Manzi S, Ahearn JM. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers. Adv Exp Med Biol. 2006; 586:381-90. PMID: 16893085.
      View in: PubMed