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    Pei-An (Betty) Shih

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0664
    CA La Jolla 92093
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      Pei-an (Betty) Shih, PhD is a Genetic Epidemiologist specializing in the molecular genetic studies of complex traits. She is assistant professor in the Department of Psychiatry, and a faculty member of the Stein Institute for Research on Aging at the University of California, San Diego (UCSD). Dr. Shih serves as Director of Didactic Training for the UCSD Research Fellowship in Biological Psychiatry and Neuroscience Program (T32). She completed a Bachelor of Music degree from University of North Carolina, a Master of Public Management degree from Carnegie Mellon University, and a PhD in Genetic Epidemiology from the University of Pittsburgh. For her postgraduate training, Dr. Shih received a National Kidney Foundation Fellowship Award to study molecular mechanisms underlying genes associated with hypertension and metabolic syndrome risk in population-based samples. Dr. Shih currently holds a National Institute of Health (NIDDK) Mentored Research Scientist Development Award to conduct genetic and lipidomics research in patients with mental illnesses. A component of this work focuses on biomarker and epidemiological studies of cardiometabolic risks and aging parameters associated with atypical antipsychotic use. Another component, and her primary research focus, utilizes a translational "OMICS" strategy to study the genetic and diet interactions underlying the pathogenesis of eating disorders. Dr. Shih’s research interests are psychiatric genetics, pharmacogenetics, the interplay of genes and environment in the causation and progression of mental illness, and the combined use of clinical assessment and biomarkers to personalize interventions and treatments.

      Collapse Research 
      Collapse Research Activities and Funding
      Solving EPHX2 and PUFA Interactions in Anorexia Nervosa
      NIH/NIMH R01MH106781Jun 21, 2016 - Mar 31, 2021
      Role: Principal Investigator
      Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
      NIH/NIDDK K01DK087813Jul 1, 2011 - Apr 30, 2015
      Role: Principal Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Joseph J, Depp C, Shih P, Cadenhead KS, Schmid-Schönbein G. Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? Front Neurosci. 2017; 11:155. PMID: 28396623.
        View in: PubMed
      2. Apple AC, Ryals AJ, Alpert KI, Wagner LI, Shih P, Dokucu M, Cella D, Penedo FJ, Voss JL, Wang L. Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns. Neuroimage Clin. 2017; 14:685-691. PMID: 28377882.
        View in: PubMed
      3. Shih P. Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa. Prostaglandins Other Lipid Mediat. 2017 Feb 21. PMID: 28232135.
        View in: PubMed
      4. Shih P, Woodside DB. Contemporary views on the genetics of anorexia nervosa. Eur Neuropsychopharmacol. 2016 Apr; 26(4):663-73. PMID: 26944296; PMCID: PMC4801707 [Available on 04/01/17].
      5. Shih P, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry. 2016 Apr; 21(4):537-46. PMID: 25824304; PMCID: PMC4591075.
      6. Johnson DC, Thom NJ, Stanley EA, Haase L, Simmons AN, Shih P, Thompson WK, Potterat EG, Minor TR, Paulus MP. Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment. Am J Psychiatry. 2014 Aug; 171(8):844-53. PMID: 24832476; PMCID: PMC4458258.
      7. Rana BK, Darst BF, Bloss C, Shih P, Depp C, Nievergelt CM, Allison M, Parsons JK, Schork N, Jeste DV. Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. Am J Geriatr Psychiatry. 2014 Oct; 22(10):997-1006.e5. PMID: 24791650; PMCID: PMC4163500.
      8. Marzola E, Nasser JA, Hashim SA, Shih P, Kaye WH. Nutritional rehabilitation in anorexia nervosa: review of the literature and implications for treatment. BMC Psychiatry. 2013 Nov 07; 13:290. PMID: 24200367; PMCID: PMC3829207.
      9. Scott-Van Zeeland AA, Bloss CS, Tewhey R, Bansal V, Torkamani A, Libiger O, Duvvuri V, Wineinger N, Galvez L, Darst BF, Smith EN, Carson A, Pham P, Phillips T, Villarasa N, Tisch R, Zhang G, Levy S, Murray S, Chen W, Srinivasan S, Berenson G, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB, Bulik CM, Keel P, Klump KL, Lilenfeld L, Plotnicov K, Topol EJ, Shih P, Magistretti P, Bergen AW, Berrettini W, Kaye W, Schork NJ. Evidence for the role of EPHX2 gene variants in anorexia nervosa. Mol Psychiatry. 2014 Jun; 19(6):724-32. PMID: 23999524; PMCID: PMC3852189.
      10. Wei Z, Zhang K, Wen G, Balasubramanian K, Shih P, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata SK, O'Connor DT. Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs. J Hypertens. 2013 Jan; 31(1):123-33. PMID: 23149563; PMCID: PMC3615981.
      11. Jin H, Shih P, Golshan S, Mudaliar S, Henry R, Glorioso DK, Arndt S, Kraemer HC, Jeste DV. Comparison of longer-term safety and effectiveness of 4 atypical antipsychotics in patients over age 40: a trial using equipoise-stratified randomization. J Clin Psychiatry. 2013 Jan; 74(1):10-8. PMID: 23218100; PMCID: PMC3600635.
      12. Kang SW, Shih P, Mathew RO, Mahata M, Biswas N, Rao F, Yan L, Bouchard J, Malhotra R, Tolwani A, Khandrika S, Mehta RL, O'Connor DT. Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences. BMC Nephrol. 2011 Jun 16; 12:27. PMID: 21679467; PMCID: PMC3154145.
      13. Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih P, Rao F, O'Connor DT, Taylor P. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther. 2011 Jul; 338(1):125-33. PMID: 21493754; PMCID: PMC3126649.
      14. Shih P, O'Connor DT. Synergistic physician and patient behavioral interventions as management strategy for effective population-based hypertension control. Curr Hypertens Rep. 2010 Jun; 12(3):149-51. PMID: 20424947; PMCID: PMC2876256.
      15. Shih P, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199513.
        View in: PubMed
      16. Shih P, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab. 2009 Nov; 94(11):4557-66. PMID: 19820027; PMCID: PMC2775651.
      17. Shih P, Manzi S, Shaw P, Kenney M, Kao AH, Bontempo F, Barmada MM, Kammerer C, Kamboh MI. Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations. J Rheumatol. 2008 Nov; 35(11):2171-8. PMID: 18793001; PMCID: PMC2582591.
      18. O'Connor DT, Zhu G, Rao F, Taupenot L, Fung MM, Das M, Mahata SK, Mahata M, Wang L, Zhang K, Greenwood TA, Shih P, Cockburn MG, Ziegler MG, Stridsberg M, Martin NG, Whitfield JB. Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure. Circulation. 2008 Jul 15; 118(3):247-57. PMID: 18591442; PMCID: PMC2654229.
      19. Shih P, O'Connor DT. Hereditary determinants of human hypertension: strategies in the setting of genetic complexity. Hypertension. 2008 Jun; 51(6):1456-64. PMID: 18413494; PMCID: PMC2587105.
      20. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih P, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
        View in: PubMed
      21. Calano SJ, Shih P, Liu CC, Kao AH, Navratil JS, Manzi S, Ahearn JM. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers. Adv Exp Med Biol. 2006; 586:381-90. PMID: 16893085.
        View in: PubMed
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