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Pei-An (Betty) Shih, MPM, PhD

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Phone858-534-6768
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    Collapse Overview 
    Collapse Overview
    Pei-an (Betty) Shih, PhD is a Genetic Epidemiologist specializing in the molecular genetic studies of complex traits. She is associate professor in the Department of Psychiatry, and a faculty member of the Moores Cancer Center at the University of California, San Diego (UCSD). Dr. Shih serves as Program Co-Director and Director of Didactic Training for the UCSD Research Fellowship in Biological Psychiatry and Neuroscience Program (T32). She is also a faculty mediator at UCSD. Dr. Shih received a Master of Public Management degree from Carnegie Mellon University, and a PhD degree in Genetic Epidemiology from University of Pittsburgh. Dr. Shih is the recipient of a Rheumatology Research Foundation Preceptorship Award, National Kidney Foundation Fellowship Award, NARSAD Young Investigator Award, National Institute of Health (NIDDK) Mentored Research Scientist Development Award (K01), and National Institute of Mental Health (NIMH) Grants (T32 and R01). Dr. Shih’s research interests are psychiatric genetics, pharmacogenetics, the interplay of genes and environment in the causation and progression of mental illness, and the combined use of clinical assessment and biomarkers to personalize interventions and treatments. The overarching theme of Dr. Shih’s research is the application of a translational "OMICS" research strategy to better understand the metabolic disturbances underlying these disorders, and to identify molecular targets for treatment development. Support for her research is provided by the National Institute of Diabetes and Digestive and Kidney Diseases, NIH Common Fund, National Institute of Mental Health, and various nonprofit foundations.


    Collapse Research 
    Collapse Research Activities and Funding
    Solving EPHX2 and PUFA Interactions in Anorexia Nervosa
    NIH/NIMH R01MH106781Jun 21, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    NIH/NIDDK K01DK087813Jul 1, 2011 - Apr 30, 2015
    Role: Principal Investigator
    Fellowship on Biological Psychiatry and Neuroscience
    NIH/NIMH T32MH018399Jul 15, 1986 - Jun 30, 2022
    Role: Co-Investigator
    Role Description: Program Co-Director

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    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Apple AC, Schroeder MP, Ryals AJ, Wagner LI, Cella D, Shih PA, Reilly J, Penedo FJ, Voss JL, Wang L. Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy. Neuroimage Clin. 2018; 20:110-118. PMID: 30094161.
      View in: PubMed
    2. Wang Y, Wang W, Sanidad KZ, Shih PA, Zhao X, Zhang G. Eicosanoid signaling in carcinogenesis of colorectal cancer. Cancer Metastasis Rev. 2018 Jun 01. PMID: 29858741.
      View in: PubMed
    3. Yang J, Shih PB. Fasting and postprandial soluble epoxide hydrolase-associated eicosanoids of remitted patients with eating disorder. Data Brief. 2018 Apr; 17:334-338. PMID: 29876402.
      View in: PubMed
    4. Shih PB, Morisseau C, Le T, Woodside B, German JB. Personalized polyunsaturated fatty acids as a potential adjunctive treatment for anorexia nervosa. Prostaglandins Other Lipid Mediat. 2017 Nov; 133:11-19. PMID: 28873340.
      View in: PubMed
    5. Joseph J, Depp C, Shih PB, Cadenhead KS, Schmid-Schönbein G. Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? Front Neurosci. 2017; 11:155. PMID: 28396623.
      View in: PubMed
    6. Apple AC, Ryals AJ, Alpert KI, Wagner LI, Shih PA, Dokucu M, Cella D, Penedo FJ, Voss JL, Wang L. Subtle hippocampal deformities in breast cancer survivors with reduced episodic memory and self-reported cognitive concerns. Neuroimage Clin. 2017; 14:685-691. PMID: 28377882.
      View in: PubMed
    7. Shih PB. Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa. Prostaglandins Other Lipid Mediat. 2017 Sep; 132:69-76. PMID: 28232135.
      View in: PubMed
    8. Shih PA, Woodside DB. Contemporary views on the genetics of anorexia nervosa. Eur Neuropsychopharmacol. 2016 Apr; 26(4):663-73. PMID: 26944296; PMCID: PMC4801707 [Available on 04/01/17].
    9. Shih PB, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry. 2016 Apr; 21(4):537-46. PMID: 25824304; PMCID: PMC4591075.
    10. Johnson DC, Thom NJ, Stanley EA, Haase L, Simmons AN, Shih PA, Thompson WK, Potterat EG, Minor TR, Paulus MP. Modifying resilience mechanisms in at-risk individuals: a controlled study of mindfulness training in Marines preparing for deployment. Am J Psychiatry. 2014 Aug; 171(8):844-53. PMID: 24832476.
      View in: PubMed
    11. Rana BK, Darst BF, Bloss C, Shih PA, Depp C, Nievergelt CM, Allison M, Parsons JK, Schork N, Jeste DV. Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. Am J Geriatr Psychiatry. 2014 Oct; 22(10):997-1006.e5. PMID: 24791650.
      View in: PubMed
    12. Marzola E, Nasser JA, Hashim SA, Shih PA, Kaye WH. Nutritional rehabilitation in anorexia nervosa: review of the literature and implications for treatment. BMC Psychiatry. 2013 Nov 07; 13:290. PMID: 24200367; PMCID: PMC3829207.
    13. Scott-Van Zeeland AA, Bloss CS, Tewhey R, Bansal V, Torkamani A, Libiger O, Duvvuri V, Wineinger N, Galvez L, Darst BF, Smith EN, Carson A, Pham P, Phillips T, Villarasa N, Tisch R, Zhang G, Levy S, Murray S, Chen W, Srinivasan S, Berenson G, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB, Bulik CM, Keel P, Klump KL, Lilenfeld L, Plotnicov K, Topol EJ, Shih PB, Magistretti P, Bergen AW, Berrettini W, Kaye W, Schork NJ. Evidence for the role of EPHX2 gene variants in anorexia nervosa. Mol Psychiatry. 2014 Jun; 19(6):724-32. PMID: 23999524; PMCID: PMC3852189.
    14. Wei Z, Zhang K, Wen G, Balasubramanian K, Shih PA, Rao F, Friese RS, Miramontes-Gonzalez JP, Schmid-Schoenbein GW, Kim HS, Mahata SK, O'Connor DT. Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs. J Hypertens. 2013 Jan; 31(1):123-33. PMID: 23149563; PMCID: PMC3615981.
    15. Jin H, Shih PA, Golshan S, Mudaliar S, Henry R, Glorioso DK, Arndt S, Kraemer HC, Jeste DV. Comparison of longer-term safety and effectiveness of 4 atypical antipsychotics in patients over age 40: a trial using equipoise-stratified randomization. J Clin Psychiatry. 2013 Jan; 74(1):10-8. PMID: 23218100.
      View in: PubMed
    16. Kang SW, Shih PA, Mathew RO, Mahata M, Biswas N, Rao F, Yan L, Bouchard J, Malhotra R, Tolwani A, Khandrika S, Mehta RL, O'Connor DT. Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences. BMC Nephrol. 2011 Jun 16; 12:27. PMID: 21679467; PMCID: PMC3154145.
    17. Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih PA, Rao F, O'Connor DT, Taylor P. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther. 2011 Jul; 338(1):125-33. PMID: 21493754; PMCID: PMC3126649.
    18. Shih PA, O'Connor DT. Synergistic physician and patient behavioral interventions as management strategy for effective population-based hypertension control. Curr Hypertens Rep. 2010 Jun; 12(3):149-51. PMID: 20424947; PMCID: PMC2876256.
    19. Shih PB, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo. Endocr Rev. 2009 Dec 01; 30(7):934. PMID: 28199513.
      View in: PubMed
    20. Shih PA, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT. Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab. 2009 Nov; 94(11):4557-66. PMID: 19820027; PMCID: PMC2775651.
    21. Shih PB, Manzi S, Shaw P, Kenney M, Kao AH, Bontempo F, Barmada MM, Kammerer C, Kamboh MI. Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations. J Rheumatol. 2008 Nov; 35(11):2171-8. PMID: 18793001; PMCID: PMC2582591.
    22. O'Connor DT, Zhu G, Rao F, Taupenot L, Fung MM, Das M, Mahata SK, Mahata M, Wang L, Zhang K, Greenwood TA, Shih PA, Cockburn MG, Ziegler MG, Stridsberg M, Martin NG, Whitfield JB. Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure. Circulation. 2008 Jul 15; 118(3):247-57. PMID: 18591442; PMCID: PMC2654229.
    23. Shih PA, O'Connor DT. Hereditary determinants of human hypertension: strategies in the setting of genetic complexity. Hypertension. 2008 Jun; 51(6):1456-64. PMID: 18413494; PMCID: PMC2587105.
    24. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
      View in: PubMed
    25. Calano SJ, Shih PA, Liu CC, Kao AH, Navratil JS, Manzi S, Ahearn JM. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers. Adv Exp Med Biol. 2006; 586:381-90. PMID: 16893085.
      View in: PubMed