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Matthew Pearn

Title(s)Associate Clinical Professor, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    The role of caveolin-1 on anesthetic-mediated neurotoxicity
    NIH/NIGMS K08GM124500May 1, 2018 - Apr 30, 2023
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2020 Sep 25. Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. PMID: 32975365.
      View in: PubMed   Mentions:    Fields:    
    2. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020 May; 124(5):585-593. Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. PMID: 32145876.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 04 04; 38(14):3394-3413. Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn ML, Maloney MT, Mobley WC, Levine JD, Wu C. PMID: 29483280.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    4. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr; 120(4):745-760. Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. PMID: 29576115.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice. Br J Anaesth. 2017 Sep 01; 119(3):465-471. Schilling JM, Kassan A, Mandyam C, Pearn ML, Voong A, Grogman GG, Risbrough VB, Niesman IR, Patel HH, Patel PM, Head BP. PMID: 28969308.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    6. The Effect of Clevidipine on Cerebral Blood Flow Velocity and Carbon Dioxide Reactivity in Human Volunteers. J Neurosurg Anesthesiol. 2016 Oct; 28(4):337-40. Lemkuil BP, Gierl BT, Patel PM, Pearn ML, Nguyen LC, Minokadeh A, Drummond JC. PMID: 26447497.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics. Cell Mol Neurobiol. 2017 May; 37(4):571-585. Pearn ML, Niesman IR, Egawa J, Sawada A, Almenar-Queralt A, Shah SB, Duckworth JL, Head BP. PMID: 27383839.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    8. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 05 02; 126(5):1815-33. Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. PMID: 27064279.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    9. An Anti-ß-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One. 2016; 11(3):e0152471. Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn ML, Pfeifer A, Muhs A, Mobley WC. PMID: 27023444.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function. J Physiol. 2016 08 15; 594(16):4565-79. Egawa J, Pearn ML, Lemkuil BP, Patel PM, Head BP. PMID: 26332795.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    11. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. PMID: 25710492.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    12. Pre-operative cellularity mapping and intra-MRI surgery: potential for improving neurosurgical biopsies. Expert Rev Med Devices. 2015 Jan; 12(1):1-5. Chen CC, White NS, Farid N, Kobalka P, Hansen L, Pearn M, Dale AM. PMID: 25373612.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15; (91):51899. Zhao X, Zhou Y, Weissmiller AM, Pearn ML, Mobley WC, Wu C. PMID: 25286194.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Aging and intellectual disability: insights from mouse models of Down syndrome. Dev Disabil Res Rev. 2013; 18(1):43-50. Ruparelia A, Pearn ML, Mobley WC. PMID: 23949828.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Curr Opin Neurobiol. 2012 Oct; 22(5):880-6. Ruparelia A, Pearn ML, Mobley WC. PMID: 22658745.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. PMID: 22198221.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    17. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology. 2011 Jan; 114(1):49-57. Lemkuil BP, Head BP, Pearn ML, Patel HH, Drummond JC, Patel PM. PMID: 21169791.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    18. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010 Dec 23; 5(12):e15697. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. PMID: 21203469.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
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