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Matthew Pearn

TitleAssociate Clinical Professor
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address200 W. Arbor Drive #8770
San Diego CA 92103
Phone619-543-6240
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of caveolin-1 on anesthetic-mediated neurotoxicity
    NIH/NIGMS K08GM124500May 1, 2018 - Apr 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sung K, Ferrari LF, Yang W, Chung C, Zhao X, Gu Y, Lin S, Zhang K, Cui B, Pearn M, Maloney MT, Mobley WC, Levine JD, Wu C. Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception. J Neurosci. 2018 Apr 04; 38(14):3394-3413. PMID: 29483280.
      View in: PubMed
    2. Pearn M, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr; 120(4):745-760. PMID: 29576115.
      View in: PubMed
    3. Schilling JM, Kassan A, Mandyam C, Pearn M, Voong A, Grogman GG, Risbrough VB, Niesman IR, Patel HH, Patel PM, Head BP. Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice. Br J Anaesth. 2017 Sep 01; 119(3):465-471. PMID: 28969308.
      View in: PubMed
    4. Lemkuil BP, Gierl BT, Patel PM, Pearn M, Nguyen LC, Minokadeh A, Drummond JC. The Effect of Clevidipine on Cerebral Blood Flow Velocity and Carbon Dioxide Reactivity in Human Volunteers. J Neurosurg Anesthesiol. 2016 Oct; 28(4):337-40. PMID: 26447497.
      View in: PubMed
    5. Pearn M, Niesman IR, Egawa J, Sawada A, Almenar-Queralt A, Shah SB, Duckworth JL, Head BP. Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics. Cell Mol Neurobiol. 2017 May; 37(4):571-585. PMID: 27383839.
      View in: PubMed
    6. Xu W, Weissmiller AM, White JA, Fang F, Wang X, Wu Y, Pearn M, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 May 02; 126(5):1815-33. PMID: 27064279; PMCID: PMC4855914.
    7. Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, Reis P, Granet A, Mlaki D, Lopez-Deber MP, Do L, Singhal N, Masliah E, Pearn M, Pfeifer A, Muhs A, Mobley WC. An Anti-ß-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. PLoS One. 2016; 11(3):e0152471. PMID: 27023444; PMCID: PMC4811554.
    8. Egawa J, Pearn M, Lemkuil BP, Patel PM, Head BP. Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function. J Physiol. 2016 08 15; 594(16):4565-79. PMID: 26332795; PMCID: PMC4983616 [Available on 08/15/17].
    9. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn M, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A ?-secretase inhibitor, but not a ?-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. PMID: 25710492; PMCID: PMC4339551.
    10. Chen CC, White NS, Farid N, Kobalka P, Hansen L, Pearn M, Dale AM. Pre-operative cellularity mapping and intra-MRI surgery: potential for improving neurosurgical biopsies. Expert Rev Med Devices. 2015 Jan; 12(1):1-5. PMID: 25373612.
      View in: PubMed
    11. Zhao X, Zhou Y, Weissmiller AM, Pearn M, Mobley WC, Wu C. Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp. 2014 Sep 15; (91):51899. PMID: 25286194; PMCID: PMC4828072.
    12. Ruparelia A, Pearn M, Mobley WC. Aging and intellectual disability: insights from mouse models of Down syndrome. Dev Disabil Res Rev. 2013; 18(1):43-50. PMID: 23949828.
      View in: PubMed
    13. Ruparelia A, Pearn M, Mobley WC. Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome. Curr Opin Neurobiol. 2012 Oct; 22(5):880-6. PMID: 22658745; PMCID: PMC3434300.
    14. Pearn M, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. PMID: 22198221; PMCID: PMC3275822.
    15. Lemkuil BP, Head BP, Pearn M, Patel HH, Drummond JC, Patel PM. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology. 2011 Jan; 114(1):49-57. PMID: 21169791; PMCID: PMC3037980.
    16. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn M, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010 Dec 23; 5(12):e15697. PMID: 21203469; PMCID: PMC3009734.
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