Ellen Breen

Title(s)Researcher, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-1962-5353 Additional info
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    Collapse Research 
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    IVIS Spectrum Imaging System
    NIH S10RR027970Jul 1, 2010 - Jun 30, 2011
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting ATP-Sensitive K+ Channels to Treat Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2022 05; 66(5):476-478. Breen E, Yuan JX. PMID: 35238728; PMCID: PMC9116352.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. IL-33/ST2 receptor-dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice. Physiol Rep. 2022 02; 10(3):e15185. Indralingam CS, Gutierrez-Gonzalez AK, Johns SC, Tsui T, Cannon DT, Fuster MM, Bigby TD, Jennings PA, Breen EC. PMID: 35150208; PMCID: PMC8839421.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease. Am J Respir Cell Mol Biol. 2021 10; 65(4):390-402. Mesarwi OA, Moya EA, Zhen X, Gautane M, Zhao H, Wegbrans Giró P, Alshebli M, McCarley KE, Breen EC, Malhotra A. PMID: 34003729; PMCID: PMC8525205.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    4. Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol. 2022 01; 295:103783. Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC. PMID: 34508866.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells. Front Physiol. 2021; 12:714785. Rodriguez M, Chen J, Jain PP, Babicheva A, Xiong M, Li J, Lai N, Zhao T, Hernandez M, Balistrieri A, Parmisano S, Simonson T, Breen E, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34408668; PMCID: PMC8364962.
      View in: PubMed   Mentions: 1  
    6. Cigarettes Make You Weak: RANKL/RANK Link Changes in Muscle and Bone. Am J Respir Cell Mol Biol. 2021 05; 64(5):533-535. Nogueira L, Breen EC. PMID: 33711242; PMCID: PMC8086038.
      View in: PubMed   Mentions: 1     Fields:    
    7. Synergistic effect of vascular endothelial growth factor gene inactivation in endothelial cells and skeletal myofibres on muscle enzyme activity, capillary supply and endurance exercise in mice. Exp Physiol. 2020 12; 105(12):2168-2177. Sulaeman A, Fine J, de Vargas-Machuca A, Vitorino SA, Wagner PD, Fruttiger M, Breen EC. PMID: 32936962.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Cigarette Smoke Triggers IL-33-associated Inflammation in a Model of Late-Stage Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 11; 61(5):567-574. Lee JH, Hailey KL, Vitorino SA, Jennings PA, Bigby TD, Breen EC. PMID: 30973786; PMCID: PMC6827064.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Skeletal myofiber VEGF deficiency leads to mitochondrial, structural, and contractile alterations in mouse diaphragm. J Appl Physiol (1985). 2019 11 01; 127(5):1360-1369. Cannon DT, Rodewohl L, Adams V, Breen EC, Bowen TS. PMID: 31487223; PMCID: PMC6879833.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proc Biol Sci. 2018 09 12; 285(1886). Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC. PMID: 30209232; PMCID: PMC6158528.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    11. Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice. J Physiol. 2018 07; 596(14):2901-2916. Nogueira L, Trisko BM, Lima-Rosa FL, Jackson J, Lund-Palau H, Yamaguchi M, Breen EC. PMID: 29797443; PMCID: PMC6046067.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    12. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R834-R847. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC. PMID: 29384700; PMCID: PMC6032308.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    13. Skeletal myofiber vascular endothelial growth factor is required for the exercise training-induced increase in dentate gyrus neuronal precursor cells. J Physiol. 2017 09 01; 595(17):5931-5943. Rich B, Scadeng M, Yamaguchi M, Wagner PD, Breen EC. PMID: 28597506; PMCID: PMC5577548.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    14. Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice. Prog Neuropsychopharmacol Biol Psychiatry. 2017 07 03; 77:1-8. Alasmari F, Crotty Alexander LE, Nelson JA, Schiefer IT, Breen E, Drummond CA, Sari Y. PMID: 28347687; PMCID: PMC5466499.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    15. Functional magnetic resonance imaging for in vivo quantification of pulmonary hypertension in the Sugen 5416/hypoxia mouse. Exp Physiol. 2017 03 01; 102(3):347-353. Breen EC, Scadeng M, Lai NC, Murray F, Bigby TD. PMID: 27897352.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Skeletal myofiber VEGF regulates contraction-induced perfusion and exercise capacity but not muscle capillarity in adult mice. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R192-9. Knapp AE, Goldberg D, Delavar H, Trisko BM, Tang K, Hogan MC, Wagner PD, Breen EC. PMID: 27225953; PMCID: PMC4967234.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. Selective Life-Long Skeletal Myofiber-Targeted VEGF Gene Ablation Impairs Exercise Capacity in Adult Mice. J Cell Physiol. 2016 Feb; 231(2):505-11. Tang K, Gu Y, Dalton ND, Wagner H, Peterson KL, Wagner PD, Breen EC. PMID: 26201683.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. Skeletal myofiber VEGF is necessary for myogenic and contractile adaptations to functional overload of the plantaris in adult mice. J Appl Physiol (1985). 2016 Jan 15; 120(2):188-95. Huey KA, Smith SA, Sulaeman A, Breen EC. PMID: 26542520; PMCID: PMC4719059.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    19. Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity. J Appl Physiol (1985). 2014 Oct 15; 117(8):880-6. Darquenne C, Borja MG, Oakes JM, Breen EC, Olfert IM, Scadeng M, Prisk GK. PMID: 25170069; PMCID: PMC4199993.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. MRI-based measurements of aerosol deposition in the lung of healthy and elastase-treated rats. J Appl Physiol (1985). 2014 Jun 15; 116(12):1561-8. Oakes JM, Breen EC, Scadeng M, Tchantchou GS, Darquenne C. PMID: 24790020; PMCID: PMC4064380.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    21. Skeletal myofiber VEGF is essential for the exercise training response in adult mice. Am J Physiol Regul Integr Comp Physiol. 2014 Apr 15; 306(8):R586-95. Delavar H, Nogueira L, Wagner PD, Hogan MC, Metzger D, Breen EC. PMID: 24523345; PMCID: PMC4043130.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    22. Impaired exercise capacity and skeletal muscle function in a mouse model of pulmonary inflammation. J Appl Physiol (1985). 2013 May; 114(9):1340-50. Tang K, Murano G, Wagner H, Nogueira L, Wagner PD, Tang A, Dalton ND, Gu Y, Peterson KL, Breen EC. PMID: 23449936; PMCID: PMC3656431.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung. J Cell Physiol. 2013 Feb; 228(2):371-9. Breen EC, Malloy JL, Tang K, Xia F, Fu Z, Hancock RE, Overhage J, Wagner PD, Spragg RG. PMID: 22718316; PMCID: PMC3484242.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging. Ann Biomed Eng. 2013 May; 41(5):967-78. Oakes JM, Scadeng M, Breen EC, Prisk GK, Darquenne C. PMID: 23354670; PMCID: PMC3625510.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    25. Rat airway morphometry measured from in situ MRI-based geometric models. J Appl Physiol (1985). 2012 Jun; 112(11):1921-31. Oakes JM, Scadeng M, Breen EC, Marsden AL, Darquenne C. PMID: 22461437; PMCID: PMC3379152.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    26. Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis. Am J Physiol Regul Integr Comp Physiol. 2010 Oct; 299(4):R1059-67. Olfert IM, Howlett RA, Wagner PD, Breen EC. PMID: 20686173; PMCID: PMC2957383.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    27. TNF-alpha-mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure. J Cell Physiol. 2010 Feb; 222(2):320-7. Tang K, Wagner PD, Breen EC. PMID: 19859910; PMCID: PMC5831677.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle. Respir Physiol Neurobiol. 2010 Jan 31; 170(1):16-22. Tang K, Xia FC, Wagner PD, Breen EC. PMID: 19853064; PMCID: PMC2826189.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    29. Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol. 2009 Apr 15; 587(Pt 8):1755-67. Olfert IM, Howlett RA, Tang K, Dalton ND, Gu Y, Peterson KL, Wagner PD, Breen EC. PMID: 19237429; PMCID: PMC2683962.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    30. Commentaries on viewpoint: use of mean airspace chord length to assess emphysema. Assessment of emphysema benefits from quantification of heterogeneity. J Appl Physiol (1985). 2008 12; 105(6):1983-4; author reply 1986-7. Rossiter HB, Breen EC. PMID: 19140248.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Analysis of endocrine disruption in Southern California coastal fish using an aquatic multispecies microarray. Environ Health Perspect. 2009 Feb; 117(2):223-30. Baker ME, Ruggeri B, Sprague LJ, Eckhardt-Ludka C, Lapira J, Wick I, Soverchia L, Ubaldi M, Polzonetti-Magni AM, Vidal-Dorsch D, Bay S, Gully JR, Reyes JA, Kelley KM, Schlenk D, Breen EC, Sásik R, Hardiman G. PMID: 19270792; PMCID: PMC2649224.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    32. Doxycycline treatment prevents alveolar destruction in VEGF-deficient mouse lung. J Cell Biochem. 2008 May 15; 104(2):525-35. Rossiter HB, Scadeng M, Tang K, Wagner PD, Breen EC. PMID: 18181212.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    33. Skeletal muscle capillarity during hypoxia: VEGF and its activation. High Alt Med Biol. 2008; 9(2):158-66. Breen E, Tang K, Olfert M, Knapp A, Wagner P. PMID: 18578647.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    34. VEGF in biological control. J Cell Biochem. 2007 Dec 15; 102(6):1358-67. Breen EC. PMID: 17979153.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    35. High-resolution three-dimensional magnetic resonance imaging of mouse lung in situ. Invest Radiol. 2007 Jan; 42(1):50-7. Scadeng M, Rossiter HB, Dubowitz DJ, Breen EC. PMID: 17213749.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    36. Temporal thrombospondin-1 mRNA response in skeletal muscle exposed to acute and chronic exercise. Growth Factors. 2006 Dec; 24(4):253-9. Olfert IM, Breen EC, Gavin TP, Wagner PD. PMID: 17381066.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    37. Muscle-targeted deletion of VEGF and exercise capacity in mice. Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):159-66. Wagner PD, Olfert IM, Tang K, Breen EC. PMID: 16344007.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    38. HIF and VEGF relationships in response to hypoxia and sciatic nerve stimulation in rat gastrocnemius. Respir Physiol Neurobiol. 2004 Nov 30; 144(1):71-80. Tang K, Breen EC, Wagner H, Brutsaert TD, Gassmann M, Wagner PD. PMID: 15522704.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    39. Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol (1985). 2004 Oct; 97(4):1559-66; discussion 1549. Tang K, Rossiter HB, Wagner PD, Breen EC. PMID: 15208295.
      View in: PubMed   Mentions: 79     Fields:    Translation:Animals
    40. Capillary regression in vascular endothelial growth factor-deficient skeletal muscle. Physiol Genomics. 2004 Jun 17; 18(1):63-9. Tang K, Breen EC, Gerber HP, Ferrara NM, Wagner PD. PMID: 15084712.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    41. Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro. J Cell Biochem. 2003 Mar 01; 88(4):848-54. Breen EC, Tang K. PMID: 12577318.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    42. Hu protein R-mediated posttranscriptional regulation of VEGF expression in rat gastrocnemius muscle. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1497-504. Tang K, Breen EC, Wagner PD. PMID: 12234802.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    43. Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulation. BMC Physiol. 2002 Jun 19; 2:8. Brutsaert TD, Gavin TP, Fu Z, Breen EC, Tang K, Mathieu-Costello O, Wagner PD. PMID: 12086595; PMCID: PMC117122.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    44. Mechanical strain increases type I collagen expression in pulmonary fibroblasts in vitro. J Appl Physiol (1985). 2000 Jan; 88(1):203-9. Breen EC. PMID: 10642382.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
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