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Piyush Patel

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address9500 Gilman Drive #9125
La Jolla CA 92093
Phone858-552-8585
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    Collapse Research 
    Collapse Research Activities and Funding
    Transcranial Laser Therapy of Ischemic Stroke
    NIH/NINDS U01NS069563Feb 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    The Role of RhoGTPases in Anesthetic-Mediated Neurotoxicity
    NIH/NIGMS R01GM085179May 1, 2010 - Nov 30, 2019
    Role: Principal Investigator
    Microarray analysis of neuronal ischemic preconditioning
    NIH/NINDS R01NS047570Jun 1, 2004 - Mar 31, 2008
    Role: Principal Investigator
    Cerebal Ischemia During Anesthesia and Surgery
    NIH/NIGMS R01GM052098Aug 1, 1995 - Apr 30, 2006
    Role: Principal Investigator
    CEREBRAL ISCHEMIA DURING ANESTHESIA AND SURGERY
    NIH/NIGMS R29GM052098Aug 1, 1995 - Apr 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2017 Jul 31; 1-12. PMID: 28981594.
      View in: PubMed
    2. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 08; 31(8):3403-3411. PMID: 28450301.
      View in: PubMed
    3. Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth DM, Patel PM, Patel HH, Head BP. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. J Neurophysiol. 2017 Jan 01; 117(1):436-444. PMID: 27832597.
      View in: PubMed
    4. Kassan A, Pham U, Nguyen Q, Reichelt ME, Cho E, Patel PM, Roth DM, Head BP, Patel HH. Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. Am J Physiol Cell Physiol. 2016 Dec 01; 311(6):C854-C865. PMID: 27707689.
      View in: PubMed
    5. Lemkuil BP, Gierl BT, Patel PM, Pearn ML, Nguyen LC, Minokadeh A, Drummond JC. The Effect of Clevidipine on Cerebral Blood Flow Velocity and Carbon Dioxide Reactivity in Human Volunteers. J Neurosurg Anesthesiol. 2016 Oct; 28(4):337-40. PMID: 26447497.
      View in: PubMed
    6. Lerman I, Davis BA, Bertram TM, Proudfoot J, Hauger RL, Coe CL, Patel PM, Baker DG. Posttraumatic stress disorder influences the nociceptive and intrathecal cytokine response to a painful stimulus in combat veterans. Psychoneuroendocrinology. 2016 Nov; 73:99-108. PMID: 27490714.
      View in: PubMed
    7. Patel P, Barkate H. Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: A randomized, open-label, multicenter clinical trial in Indian population. Indian J Endocrinol Metab. 2016 Jan-Feb; 20(1):67-71. PMID: 26904471; PMCID: PMC4743387.
      View in: PubMed, PubMed Central
    8. Egawa J, Pearn ML, Lemkuil BP, Patel PM, Head BP. Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function. J Physiol. 2016 08 15; 594(16):4565-79. PMID: 26332795; PMCID: PMC4983616 [Available on 08/15/17].
      View in: PubMed, PubMed Central
    9. Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2017 01 15; 81(2):101-110. PMID: 26592463.
      View in: PubMed
    10. Agrawal S, Patel P, Agrawal A, Makhijani N, Markert R, Deidrich W. Metformin use and the risk of esophageal cancer in Barrett esophagus. South Med J. 2014 Dec; 107(12):774-9. PMID: 25502158.
      View in: PubMed
    11. Vutskits L, Patel P. Pushing the standards forward: in-depth monitoring of physiological parameters in anesthetized neonatal mice. Anesth Analg. 2014 Nov; 119(5):1029-31. PMID: 25329021.
      View in: PubMed
    12. Wagner M, Ryu YK, Smith SC, Patel P, Mintz CD. Review: effects of anesthetics on brain circuit formation. J Neurosurg Anesthesiol. 2014 Oct; 26(4):358-62. PMID: 25144504; PMCID: PMC4700880.
      View in: PubMed, PubMed Central
    13. Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth DM, Yue Y, Patel HH. Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent. Anesthesiology. 2014 Sep; 121(3):538-48. PMID: 24821070; PMCID: PMC4219636.
      View in: PubMed, PubMed Central
    14. Drummond JC, Blake J, Patel PM, Clopton P, Schulteis G. Perioperative hypertension: white coat, masked, and appropriately referred for treatment. J Neurosurg Anesthesiol. 2014 Jul; 26(3):265. PMID: 24275936.
      View in: PubMed
    15. Moeller-Bertram T, Strigo IA, Simmons AN, Schilling JM, Patel P, Baker DG. Evidence for acute central sensitization to prolonged experimental pain in posttraumatic stress disorder. Pain Med. 2014 May; 15(5):762-71. PMID: 24738563.
      View in: PubMed
    16. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 01; 267:6-11. PMID: 24657594; PMCID: PMC4059187.
      View in: PubMed, PubMed Central
    17. Agorastos A, Hauger RL, Barkauskas DA, Moeller-Bertram T, Clopton PL, Haji U, Lohr JB, Geracioti TD, Patel PM, Chrousos GP, Baker DG. Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. Psychoneuroendocrinology. 2014 Jun; 44:71-82. PMID: 24767621.
      View in: PubMed
    18. Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, Cui W, Voong A, Krajewski S, Ali SS, Roth DM, Patel HH, Patel PM, Head BP. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation. 2014 Mar 03; 11:39. PMID: 24593993; PMCID: PMC3975903.
      View in: PubMed, PubMed Central
    19. Vyas FI, Rana DA, Patel PM, Patel VJ, Bhavsar RH. Randomized comparative trial of efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children. Perspect Clin Res. 2014 Jan; 5(1):25-31. PMID: 24551584; PMCID: PMC3915365.
      View in: PubMed, PubMed Central
    20. Niesman IR, Zemke N, Fridolfsson HN, Haushalter KJ, Levy K, Grove A, Schnoor R, Finley JC, Patel PM, Roth DM, Head BP, Patel HH. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia. Mol Cell Neurosci. 2013 Sep; 56:283-97. PMID: 23851187; PMCID: PMC3791173.
      View in: PubMed, PubMed Central
    21. Baker DG, Bertram TM, Patel PM, Barkauskas DA, Clopton P, Patel S, Geracioti TD, Haji U, O'Connor DT, Nievergelt CM, Hauger RL. Characterization of cerebrospinal fluid (CSF) and plasma NPY levels in normal volunteers over a 24-h timeframe. Psychoneuroendocrinology. 2013 Oct; 38(10):2378-82. PMID: 23759334.
      View in: PubMed
    22. Panneerselvam M, Ali SS, Finley JC, Kellerhals SE, Migita MY, Head BP, Patel PM, Roth DM, Patel HH. Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent. Mol Nutr Food Res. 2013 Jun; 57(6):1007-14. PMID: 23625721; PMCID: PMC3835714.
      View in: PubMed, PubMed Central
    23. Drummond JC, Blake JL, Patel PM, Clopton P, Schulteis G. An observational study of the influence of "white-coat hypertension" on day-of-surgery blood pressure determinations. J Neurosurg Anesthesiol. 2013 Apr; 25(2):154-61. PMID: 23211641.
      View in: PubMed
    24. Drummond JC, Patel PM. Cerebral saturation and cerebral blood flow in head-injured patients. Neurosurg Focus. 2012 Dec; 33(6):E12: 1; author reply E12: 1-2. PMID: 23199424.
      View in: PubMed
    25. Stary CM, Tsutsumi YM, Patel PM, Head BP, Patel HH, Roth DM. Caveolins: targeting pro-survival signaling in the heart and brain. Front Physiol. 2012; 3:393. PMID: 23060817; PMCID: PMC3464704.
      View in: PubMed, PubMed Central
    26. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 2012 Nov; 26(11):4637-49. PMID: 22859372; PMCID: PMC4050367.
      View in: PubMed, PubMed Central
    27. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 2012 Feb; 116(2):352-61. PMID: 22198221; PMCID: PMC3275822.
      View in: PubMed, PubMed Central
    28. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth DM, Patel HH. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 2011 Sep; 115(3):499-508. PMID: 21862885; PMCID: PMC3162469.
      View in: PubMed, PubMed Central
    29. Drummond JC, Patel PM, Lemkuil B. Proscribing the use of albumin in the head-injured patient is not warranted. Anesth Analg. 2011 Aug; 113(2):426-7; author reply 427-8. PMID: 21788329.
      View in: PubMed
    30. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem. 2011 Sep 23; 286(38):33310-21. PMID: 21799010; PMCID: PMC3190943.
      View in: PubMed, PubMed Central
    31. Panneerselvam M, Patel PM, Roth DM, Kidd MW, Chin-Lee B, Head BP, Niesman IR, Inoue S, Patel HH, Davis DP. Role of decoy molecules in neuronal ischemic preconditioning. Life Sci. 2011 Apr 11; 88(15-16):670-4. PMID: 21315738; PMCID: PMC3070046.
      View in: PubMed, PubMed Central
    32. Lemkuil BP, Head BP, Pearn ML, Patel HH, Drummond JC, Patel PM. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin depolymerization. Anesthesiology. 2011 Jan; 114(1):49-57. PMID: 21169791; PMCID: PMC3037980.
      View in: PubMed, PubMed Central
    33. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010 Dec 23; 5(12):e15697. PMID: 21203469; PMCID: PMC3009734.
      View in: PubMed, PubMed Central
    34. Panneerselvam M, Tsutsumi YM, Bonds JA, Horikawa YT, Saldana M, Dalton ND, Head BP, Patel PM, Roth DM, Patel HH. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on delta-opioid receptor stimulation. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):H1604-9. PMID: 20833967; PMCID: PMC2993198.
      View in: PubMed, PubMed Central
    35. Drummond JC, Head BP, Patel PM. Statins might contribute to postoperative delirium. Anesthesiology. 2010 Aug; 113(2):500-1. PMID: 20657207.
      View in: PubMed
    36. Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, Patel HH. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology. 2010 May; 112(5):1136-45. PMID: 20418694; PMCID: PMC2860616.
      View in: PubMed, PubMed Central
    37. Crosby G, Culley DJ, Patel PM. At the sharp end of spines: anesthetic effects on synaptic remodeling in the developing brain. Anesthesiology. 2010 Mar; 112(3):521-3. PMID: 20124984; PMCID: PMC2828506.
      View in: PubMed, PubMed Central
    38. Dawley JD, Moeller-Bertram T, Wallace MS, Patel PM. Intra-arterial injection in the rat brain: evaluation of steroids used for transforaminal epidurals. Spine (Phila Pa 1976). 2009 Jul 15; 34(16):1638-43. PMID: 19770605.
      View in: PubMed
    39. Patel P, Sun L. Update on neonatal anesthetic neurotoxicity: insight into molecular mechanisms and relevance to humans. Anesthesiology. 2009 Apr; 110(4):703-8. PMID: 19276968; PMCID: PMC2737718.
      View in: PubMed, PubMed Central
    40. Head BP, Patel HH, Niesman IR, Drummond JC, Roth DM, Patel PM. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology. 2009 Apr; 110(4):813-25. PMID: 19293698; PMCID: PMC2767332.
      View in: PubMed, PubMed Central
    41. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation. 2008 Nov 04; 118(19):1979-88. PMID: 18936328; PMCID: PMC2676165.
      View in: PubMed, PubMed Central
    42. Lerman J, Kharasch ED, Eisenach JC, Warner MA, Jevtovic-Todorovic V, Patel PM, Sun LS. Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting. Anesthesiology. 2008 Sep; 109(3):365. PMID: 18754137.
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    43. Drummond JC, Dao AV, Roth DM, Cheng CR, Atwater BI, Minokadeh A, Pasco LC, Patel PM. Effect of dexmedetomidine on cerebral blood flow velocity, cerebral metabolic rate, and carbon dioxide response in normal humans. Anesthesiology. 2008 Feb; 108(2):225-32. PMID: 18212567.
      View in: PubMed
    44. Head BP, Patel P. Anesthetics and brain protection. Curr Opin Anaesthesiol. 2007 Oct; 20(5):395-9. PMID: 17873591.
      View in: PubMed
    45. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008 Mar; 22(3):828-40. PMID: 17905724.
      View in: PubMed
    46. Feng Z, Davis DP, Sásik R, Patel HH, Drummond JC, Patel PM. Pathway and gene ontology based analysis of gene expression in a rat model of cerebral ischemic tolerance. Brain Res. 2007 Oct 26; 1177:103-23. PMID: 17916339.
      View in: PubMed
    47. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 2007 May; 21(7):1565-74. PMID: 17272740.
      View in: PubMed
    48. Kurita N, Kawaguchi M, Kakimoto M, Yamamoto Y, Inoue S, Nakamura M, Konishi N, Patel PM, Furuya H. Reevaluation of gray and white matter injury after spinal cord ischemia in rabbits. Anesthesiology. 2006 Aug; 105(2):305-12. PMID: 16871064.
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    49. Inoue S, Davis DP, Drummond JC, Cole DJ, Patel PM. The combination of isoflurane and caspase 8 inhibition results in sustained neuroprotection in rats subject to focal cerebral ischemia. Anesth Analg. 2006 May; 102(5):1548-55. PMID: 16632840.
      View in: PubMed
    50. Drummond JC, Patel PM. Editorial Board reproached for publication of BIS-mortality correlation. Anesth Analg. 2005 Oct; 101(4):1238-9; author reply 1240-1. PMID: 16192553.
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    51. Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, Tong G, Potkin SG, Fallon J, Hansen L, Mufson EJ, Kordower JH, Gall C, Conner J. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med. 2005 May; 11(5):551-5. PMID: 15852017.
      View in: PubMed
    52. Drummond JC, Cole DJ, Patel PM. Etomidate, transfusion, and vasospasm. J Neurosurg. 2005 Mar; 102(3):583-4; author reply 585-6. PMID: 15796403.
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    53. Drummond JC, McKay LD, Cole DJ, Patel PM. The role of nitric oxide synthase inhibition in the adverse effects of etomidate in the setting of focal cerebral ischemia in rats. Anesth Analg. 2005 Mar; 100(3):841-6, table of contents. PMID: 15728077.
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    54. Kawaguchi M, Furuya H, Patel PM. Neuroprotective effects of anesthetic agents. J Anesth. 2005; 19(2):150-6. PMID: 15875133.
      View in: PubMed
    55. Inoue S, Drummond JC, Davis DP, Cole DJ, Patel PM. Combination of isoflurane and caspase inhibition reduces cerebral injury in rats subjected to focal cerebral ischemia. Anesthesiology. 2004 Jul; 101(1):75-81. PMID: 15220774.
      View in: PubMed
    56. Patel P. No magic bullets: the ephemeral nature of anesthetic-mediated neuroprotection. Anesthesiology. 2004 May; 100(5):1049-51. PMID: 15114198.
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    57. Kawaguchi M, Drummond JC, Cole DJ, Kelly PJ, Spurlock MP, Patel PM. Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. Anesth Analg. 2004 Mar; 98(3):798-805, table of contents. PMID: 14980940.
      View in: PubMed
    58. Davis DP, Patel PM. Ischemic preconditioning in the brain. Curr Opin Anaesthesiol. 2003 Oct; 16(5):447-52. PMID: 17021495.
      View in: PubMed
    59. Monroe E, Finn A, Patel P, Guerrero R, Ratner P, Bernstein D. Efficacy and safety of desloratadine 5 mg once daily in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial. J Am Acad Dermatol. 2003 Apr; 48(4):535-41. PMID: 12664016.
      View in: PubMed
    60. Patel PM, Drummond JC, Cole DJ, Kelly PJ, Watson M. Isoflurane and pentobarbital reduce the frequency of transient ischemic depolarizations during focal ischemia in rats. Anesth Analg. 1998 Apr; 86(4):773-80. PMID: 9539600.
      View in: PubMed
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