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    Stephan Lange

    Address9500 Gilman Drive #0613-C
    CA La Jolla 92093
    Phone858-822-4618
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      International Society for Heart Research2014ISHR Young Investigator Award (Winner Senior Group)
      NIH2011NIH K99 Pathway to Independence Award
      2010Travel Award of the European Muscle Conference (EMC)
      2009University of San Diego Cardiovascular Scholarship Award
      2007Travel Award of the British Society of Cell Biology
      2007Travel Award of the Swiss Society of Cell Biology
      2007Poster Award of the European Muscle Conference (EMC)
      Swiss Federal Institute of Technology2006Medal of the Swiss Federal Institute of Technology
      2005Travel Award of the Weinstein Conference on Cardiovascular Development
      2005Travel Award of the British Society of Cell Biology

      Collapse Overview 
      Collapse Overview
      Dr. Lange's laboratory investigates the development and function of heart and skeletal muscles. The research focus is centered on the identification of molecular origins and pathways that lead to the development of cardiomyopathies and muscular dystrophies. We are particularly interested how mutations in sarcomeric and muscle associated proteins lead to the development of these diseases.


      Collapse Research 
      Collapse Research Activities and Funding
      Signaling Pathways in Dilated Cardiomyopathy
      NIH/NHLBI R01HL128457Aug 1, 2015 - Jul 31, 2020
      Role: Principal Investigator
      Cullin mediated protein turnover in skeletal and cardiac muscles
      NIH/NHLBI R00HL107744Apr 1, 2011 - Mar 31, 2016
      Role: Principal Investigator
      Cullin mediated protein turnover in skeletal and cardiac muscles
      NIH/NHLBI K99HL107744Apr 1, 2011 - Mar 31, 2013
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01; 127(8):3189-3200. PMID: 28737513.
        View in: PubMed
      2. Blondelle J, Shapiro P, Domenighetti AA, Lange S. Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. J Mol Biol. 2017 Apr 07; 429(7):1045-1066. PMID: 28238764.
        View in: PubMed
      3. Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biol. 2016 Sep; 6(9). PMID: 27683155.
        View in: PubMed
      4. Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E. MLP and CARP are linked to chronic PKCa signalling in dilated cardiomyopathy. Nat Commun. 2016; 7:12120. PMID: 27353086.
        View in: PubMed
      5. Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J. Cypher and enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015; 4(5). PMID: 25944877.
        View in: PubMed
      6. Blondelle J, Lange S, Greenberg BH, Cowling RT. Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol. 2015 May 1; 308(9):H974-6. PMID: 25747750.
        View in: PubMed
      7. Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, Del Álamo JC, Nigam V. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-ß signaling. J Mol Cell Cardiol. 2015 Feb; 79:133-44. PMID: 25446186.
        View in: PubMed
      8. Lun AS, Chen J, Lange S. Probing Muscle Ankyrin-Repeat Protein (MARP) Structure and Function. Anat Rec (Hoboken). 2014 Sep; 297(9):1615-29. PMID: 25125175.
        View in: PubMed
      9. Lange S, Edström L, Udd B, Gautel M. Reply: Hereditary myopathy with early respiratory failure is caused by mutations in the titin FN3 119 domain. Brain. 2014 Jun; 137(Pt 6):e279. PMID: 24569025.
        View in: PubMed
      10. Ehler E, Moore-Morris T, Lange S. Isolation and culture of neonatal mouse cardiomyocytes. J Vis Exp. 2013; (79). PMID: 24056408.
        View in: PubMed
      11. Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, Jiang L, Cai Y, Mu Y, Sheikh F, Ye S, Chen J, Ke Y, Cheng H. Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013 Oct 11; 288(41):29403-13. PMID: 23996002.
        View in: PubMed
      12. Lyon RC, Lange S, Sheikh F. Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med. 2013 Apr; 19(4):239-49. PMID: 23453282.
        View in: PubMed
      13. Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, Reggiani C, Lange S, Peter AK, Chen J, Sorrentino V. Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol. 2013 Feb 18; 200(4):523-36. PMID: 23420875.
        View in: PubMed
      14. Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84. PMID: 22778266.
        View in: PubMed
      15. Lange S, Perera S, Teh P, Chen J. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 2012 Jul; 23(13):2490-504. PMID: 22573887.
        View in: PubMed
      16. Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J. Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 3; 110(3):456-64. PMID: 22158707.
        View in: PubMed
      17. Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C, Ehler E. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. J Cell Biol. 2010 Dec 13; 191(6):1159-72. PMID: 21149568.
        View in: PubMed
      18. DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010; 5(9):e13039. PMID: 20885963.
        View in: PubMed
      19. Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15; 19(2):329-41. PMID: 19864491.
        View in: PubMed
      20. Lange S, Ouyang K, Meyer G, Cui L, Cheng H, Lieber RL, Chen J. Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci. 2009 Aug 1; 122(Pt 15):2640-50. PMID: 19584095.
        View in: PubMed
      21. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. PMID: 19033658.
        View in: PubMed
      22. Fukuzawa A, Lange S, Holt M, Vihola A, Carmignac V, Ferreiro A, Udd B, Gautel M. Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. J Cell Sci. 2008 Jun 1; 121(Pt 11):1841-51. PMID: 18477606.
        View in: PubMed
      23. Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard JC, Agarkova I. Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008 Feb 15; 376(2):338-51. PMID: 18177667.
        View in: PubMed
      24. Sheikh F, Bang ML, Lange S, Chen J. "Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med. 2007 Nov; 17(8):258-62. PMID: 18021935.
        View in: PubMed
      25. Müller S, Lange S, Gautel M, Wilmanns M. Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin. J Mol Biol. 2007 Aug 10; 371(2):469-80. PMID: 17574571.
        View in: PubMed
      26. Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, Wilmanns M. Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol. 2006 Aug; 155(2):239-50. PMID: 16713295.
        View in: PubMed
      27. Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M. Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature. 2006 Jan 12; 439(7073):229-33. PMID: 16407954.
        View in: PubMed
      28. Lange S, Ehler E, Gautel M. From A to Z and back? Multicompartment proteins in the sarcomere. Trends Cell Biol. 2006 Jan; 16(1):11-8. PMID: 16337382.
        View in: PubMed
      29. Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edström L, Ehler E, Udd B, Gautel M. The kinase domain of titin controls muscle gene expression and protein turnover. Science. 2005 Jun 10; 308(5728):1599-603. PMID: 15802564.
        View in: PubMed
      30. Lange S, Himmel M, Auerbach D, Agarkova I, Hayess K, Fürst DO, Perriard JC, Ehler E. Dimerisation of myomesin: implications for the structure of the sarcomeric M-band. J Mol Biol. 2005 Jan 14; 345(2):289-98. PMID: 15571722.
        View in: PubMed
      31. Lange S, Agarkova I, Perriard JC, Ehler E. The sarcomeric M-band during development and in disease. J Muscle Res Cell Motil. 2005; 26(6-8):375-9. PMID: 16470337.
        View in: PubMed
      32. Agarkova I, Ehler E, Lange S, Schoenauer R, Perriard JC. M-band: a safeguard for sarcomere stability? J Muscle Res Cell Motil. 2003; 24(2-3):191-203. PMID: 14609030.
        View in: PubMed
      33. Lange S, Auerbach D, McLoughlin P, Perriard E, Schäfer BW, Perriard JC, Ehler E. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. J Cell Sci. 2002 Dec 15; 115(Pt 24):4925-36. PMID: 12432079.
        View in: PubMed
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