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Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases. Int J Mol Sci. 2024 Jan 19; 25(2).
Actis Dato V, Lange S, Cho Y. PMID: 38279217; PMCID: PMC10816475.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden. Biochem Mol Biol Educ. 2023 Sep-Oct; 51(5):508-519.
Lange S, Soták M, Hagberg CE, Bagunu G, Vigmo S, Börgeson E. PMID: 37354049; PMCID: PMC10592423.
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HumansCellsPHPublic Health
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The N2A region of titin has a unique structural configuration. J Gen Physiol. 2021 07 05; 153(7).
Stronczek C, Lange S, Bullard B, Wolniak S, Börgeson E, Mayans O, Fleming JR. PMID: 33836065; PMCID: PMC8042602.
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PubMed Mentions:
8 Fields:
Translation:
Cells
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Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 06 01; 131(11).
Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. PMID: 33857019; PMCID: PMC8159691.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students. BMC Med Educ. 2021 May 22; 21(1):294.
Börgeson E, Sotak M, Kraft J, Bagunu G, Biörserud C, Lange S. PMID: 34022871; PMCID: PMC8140581.
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PubMed Mentions:
5 Fields:
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HumansCellsPHPublic Health
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Exploring Obscurin and SPEG Kinase Biology. J Clin Med. 2021 Mar 02; 10(5).
Fleming JR, Rani A, Kraft J, Zenker S, Börgeson E, Lange S. PMID: 33801198; PMCID: PMC7957886.
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PubMed Mentions:
8
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Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism. J Mol Biol. 2021 04 30; 433(9):166901.
Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O. PMID: 33647290; PMCID: PMC8052292.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. Int J Mol Sci. 2020 Oct 26; 21(21).
Blondelle J, Biju A, Lange S. PMID: 33114658; PMCID: PMC7672578.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Sci Rep. 2019 10 28; 9(1):15385.
Rajan MR, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton NJ, Biörserud C, Lindahl TL, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman JW, Perkins R, Wallenius V, Lange S, Börgeson E. PMID: 31659186; PMCID: PMC6817872.
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PubMed Mentions:
8 Fields:
Translation:
HumansCTClinical Trials
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miR-486 is modulated by stretch and increases ventricular growth. JCI Insight. 2019 09 12; 4(19).
Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V. PMID: 31513548; PMCID: PMC6795397.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol. 2019; 2:178.
Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Estève E, Sorrentino V, Ghassemian M, Lange S. PMID: 31098411; PMCID: PMC6509138.
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12 Translation:
HumansAnimalsCells
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Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. JCI Insight. 2019 04 16; 5.
Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. PMID: 30990797; PMCID: PMC6542616.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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PKC and PKN in heart disease. J Mol Cell Cardiol. 2019 03; 128:212-226.
Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S. PMID: 30742812; PMCID: PMC6408329.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res. 2020 03; 1867(3):118440.
Lange S, Pinotsis N, Agarkova I, Ehler E. PMID: 30738787; PMCID: PMC7023976.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion. J Mol Cell Cardiol. 2018 08; 121:287-296.
Ehsan M, Kelly M, Hooper C, Yavari A, Beglov J, Bellahcene M, Ghataorhe K, Poloni G, Goel A, Kyriakou T, Fleischanderl K, Ehler E, Makeyev E, Lange S, Ashrafian H, Redwood C, Davies B, Watkins H, Gehmlich K. PMID: 30048712; PMCID: PMC6117453.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01; 127(8):3189-3200.
Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. PMID: 28737513; PMCID: PMC5531406.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. J Mol Biol. 2017 04 07; 429(7):1045-1066.
Blondelle J, Shapiro P, Domenighetti AA, Lange S. PMID: 28238764; PMCID: PMC5395100.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biol. 2016 Sep; 6(9).
Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. PMID: 27683155; PMCID: PMC5043576.
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11 Fields:
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MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy. Nat Commun. 2016 06 29; 7:12120.
Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E. PMID: 27353086; PMCID: PMC4931343.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015 May 05; 4(5).
Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J. PMID: 25944877; PMCID: PMC4599425.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H974-6.
Blondelle J, Lange S, Greenberg BH, Cowling RT. PMID: 25747750; PMCID: PMC4578146.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling. J Mol Cell Cardiol. 2015 Feb; 79:133-44.
Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V. PMID: 25446186; PMCID: PMC4302020.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Probing muscle ankyrin-repeat protein (MARP) structure and function. Anat Rec (Hoboken). 2014 Sep; 297(9):1615-29.
Lun AS, Chen J, Lange S. PMID: 25125175; PMCID: PMC4135402.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Reply: Hereditary myopathy with early respiratory failure is caused by mutations in the titin FN3 119 domain. Brain. 2014 Jun; 137(Pt 6):e279.
Lange S, Edström L, Udd B, Gautel M. PMID: 24569025; PMCID: PMC4032095.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Isolation and culture of neonatal mouse cardiomyocytes. J Vis Exp. 2013 Sep 06; (79).
Ehler E, Moore-Morris T, Lange S. PMID: 24056408; PMCID: PMC3857885.
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PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013 Oct 11; 288(41):29403-13.
Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, Jiang L, Cai Y, Mu Y, Sheikh F, Ye S, Chen J, Ke Y, Cheng H. PMID: 23996002; PMCID: PMC3795241.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med. 2013 Apr; 19(4):239-49.
Lyon RC, Lange S, Sheikh F. PMID: 23453282; PMCID: PMC3622835.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol. 2013 Feb 18; 200(4):523-36.
Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, Reggiani C, Lange S, Peter AK, Chen J, Sorrentino V. PMID: 23420875; PMCID: PMC3575540.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84.
Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. PMID: 22778266; PMCID: PMC3436149.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 2012 Jul; 23(13):2490-504.
Lange S, Perera S, Teh P, Chen J. PMID: 22573887; PMCID: PMC3386213.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 03; 110(3):456-64.
Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J. PMID: 22158707; PMCID: PMC3739283.
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PubMed Mentions:
36 Fields:
Translation:
Animals
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Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. J Cell Biol. 2010 Dec 13; 191(6):1159-72.
Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C, Ehler E. PMID: 21149568; PMCID: PMC3002041.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010 Sep 27; 5(9):e13039.
DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. PMID: 20885963; PMCID: PMC2946408.
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PubMed Mentions:
119 Fields:
Translation:
HumansAnimalsCells
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Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15; 19(2):329-41.
Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J. PMID: 19864491; PMCID: PMC2796894.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimalsCells
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Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci. 2009 Aug 01; 122(Pt 15):2640-50.
Lange S, Ouyang K, Meyer G, Cui L, Cheng H, Lieber RL, Chen J. PMID: 19584095; PMCID: PMC2909316.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80.
Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. PMID: 19033658; PMCID: PMC2575833.
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PubMed Mentions:
136 Fields:
Translation:
AnimalsCells
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Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. J Cell Sci. 2008 Jun 01; 121(11):1841-51.
Fukuzawa A, Lange S, Holt M, Vihola A, Carmignac V, Ferreiro A, Udd B, Gautel M. PMID: 18477606.
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PubMed Mentions:
98 Fields:
Translation:
AnimalsCells
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Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J. 2008 Jan 09; 27(1):253-64.
Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M. PMID: 18059477; PMCID: PMC2206126.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008 Feb 15; 376(2):338-51.
Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard JC, Agarkova I. PMID: 18177667.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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"Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med. 2007 Nov; 17(8):258-62.
Sheikh F, Bang ML, Lange S, Chen J. PMID: 18021935; PMCID: PMC2134983.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin. J Mol Biol. 2007 Aug 10; 371(2):469-80.
Müller S, Lange S, Gautel M, Wilmanns M. PMID: 17574571.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol. 2006 Aug; 155(2):239-50.
Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, Wilmanns M. PMID: 16713295.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature. 2006 Jan 12; 439(7073):229-33.
Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M. PMID: 16407954.
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PubMed Mentions:
75 Fields:
Translation:
AnimalsCells
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Experimental reconstruction of a long-period grating from its core-to-core transmission spectrum. Opt Lett. 2005 Dec 15; 30(24):3272-4.
Rosenthal A, Horowitz M, Lange S, Shäffer C. PMID: 16389802.
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PubMed Mentions: Fields:
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From A to Z and back? Multicompartment proteins in the sarcomere. Trends Cell Biol. 2006 Jan; 16(1):11-8.
Lange S, Ehler E, Gautel M. PMID: 16337382.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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The kinase domain of titin controls muscle gene expression and protein turnover. Science. 2005 Jun 10; 308(5728):1599-603.
Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edström L, Ehler E, Udd B, Gautel M. PMID: 15802564.
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PubMed Mentions:
262 Fields:
Translation:
HumansAnimalsCells
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Dimerisation of myomesin: implications for the structure of the sarcomeric M-band. J Mol Biol. 2005 Jan 14; 345(2):289-98.
Lange S, Himmel M, Auerbach D, Agarkova I, Hayess K, Fürst DO, Perriard JC, Ehler E. PMID: 15571722.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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The sarcomeric M-band during development and in disease. J Muscle Res Cell Motil. 2005; 26(6-8):375-9.
Lange S, Agarkova I, Perriard JC, Ehler E. PMID: 16470337.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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The effect of curtailed hospitalization on the management and outcome of lumbar discectomy patients in a private practice setting. Conn Med. 2004 Mar; 68(3):139-45.
Lange SC, Bernstein B, Lange CL, Perkins SB. PMID: 15058503.
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Translation:
Humans
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M-band: a safeguard for sarcomere stability? J Muscle Res Cell Motil. 2003; 24(2-3):191-203.
Agarkova I, Ehler E, Lange S, Schoenauer R, Perriard JC. PMID: 14609030.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. J Cell Sci. 2002 Dec 15; 115(Pt 24):4925-36.
Lange S, Auerbach D, McLoughlin P, Perriard E, Schäfer BW, Perriard JC, Ehler E. PMID: 12432079.
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PubMed Mentions:
118 Fields:
Translation:
AnimalsCells