Stephan Lange

Title(s)Associate Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailslange@ucsd.edu
ORCID ORCID Icon0000-0001-9361-6602 Additional info
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    Collapse Biography 
    Collapse education and training
    Humboldt University, Berlin, GermanyDipl. Biol. (MSc equivalent)2001Molecular Biology, Biochemistry, Biophysics
    Swiss Federal Institute of Technology (ETH), Zurich, SwitzerlandDr. sci. nat. (PhD equivalent)2005Cell Biology
    Collapse awards and honors
    International Society for Heart Research2019Junior Faculty Travel Award
    Journal of Molecular Biology2017Spotlight on Early Career Researchers
    International Society for Heart Research2016Travel Award
    UC San Diego2016Schulman Award for Outstanding Cardiovascular Research
    International Society for Heart Research2014ISHR Young Investigator Award (Winner Senior Group)
    NIH2011NIH K99 Pathway to Independence Award
    2010Travel Award of the European Muscle Conference (EMC)
    2009University of San Diego Cardiovascular Scholarship Award
    2007Poster Award of the European Muscle Conference (EMC)
    2007Travel Award of the British Society of Cell Biology
    2007Travel Award of the Swiss Society of Cell Biology
    Swiss Federal Institute of Technology2006Medal of the Swiss Federal Institute of Technology
    2005Travel Award of the Weinstein Conference on Cardiovascular Development
    2005Travel Award of the British Society of Cell Biology

    Collapse Overview 
    Collapse overview
    Dr. Lange's laboratory investigates the development and function of heart and skeletal muscles. The research focus is centered on the identification of molecular origins and pathways that lead to the development of cardiomyopathies and muscular dystrophies. We are particularly interested how mutations in sarcomeric and muscle associated proteins lead to the development of these diseases.

    Collapse Research 
    Collapse research activities and funding
    Ankrd1: a novel biomarker and therapeutic target for dilated cardiomyopathy
    Danmarks Frie Forskningsfond (DFF) Jun 1, 2024 - May 31, 2027
    Role: PI
    Starting Grant
    Aarhus University Research Foundation AUFF-E-2022-7-9Jan 1, 2023 - Dec 31, 2025
    Role: PI
    Revealing roles of cullin-linked protein degradation for the development of neuromuscular disorders
    Lundbeck Foundation R396-2022-189Jan 1, 2023 - Jan 31, 2023
    Role: PI
    Revealing roles of cullin-linked protein degradation for the development of neuromuscular disorders
    Lundbeck Foundation R396-2022-189Jan 1, 2023 - Jan 31, 2023
    Role: PI
    Revealing roles of cullin-linked protein degradation for the development of neuromuscular disorders
    Lundbeck Foundation R396-2022-189Jan 1, 2023 - Jan 31, 2023
    Role: PI
    Starting Grant
    Novo Nordisk Foundation NNF22OC0079368Oct 1, 2022 - Sep 30, 2025
    Role: PI
    The role of obscurin and Obsl1 as key determinants for diastolic function
    NIH R01HL152251Feb 1, 2021 - Jan 31, 2025
    Role: Principal Investigator
    Signaling Pathways in Dilated Cardiomyopathy
    NIH R01HL128457Aug 1, 2015 - Jul 31, 2021
    Role: Principal Investigator
    Cullin mediated protein turnover in skeletal and cardiac muscles
    NIH R00HL107744Apr 1, 2011 - Mar 31, 2017
    Role: Principal Investigator
    Cullin mediated protein turnover in skeletal and cardiac muscles
    NIH K99HL107744Apr 1, 2011 - Mar 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy. Circ Heart Fail. 2025 Apr; 18(4):e011867. Fujita K, Desmond P, Blondelle J, Soták M, Rajan MR, Clark M, Estève É, Chan Y, Gu Y, Actis Dato V, Marrocco V, Dalton ND, Ghassemian M, Do A, Klos M, Peterson KL, Sheikh F, Cho Y, Börgeson E, Lange S. PMID: 40066567; PMCID: PMC11995854.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. The challenges of assessing adiposity in a clinical setting. Nat Rev Endocrinol. 2024 Oct; 20(10):615-626. Börgeson E, Tavajoh S, Lange S, Jessen N. PMID: 39009863.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases. Int J Mol Sci. 2024 Jan 19; 25(2). Actis Dato V, Lange S, Cho Y. PMID: 38279217; PMCID: PMC10816475.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    4. Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden. Biochem Mol Biol Educ. 2023 Sep-Oct; 51(5):508-519. Lange S, Soták M, Hagberg CE, Bagunu G, Vigmo S, Börgeson E. PMID: 37354049; PMCID: PMC10592423.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    5. Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures. iScience. 2022 Jul 15; 25(7):104602. Soták M, Rajan MR, Clark M, Harms M, Rani A, Kraft JD, Tandio D, Shen T, Borkowski K, Fiehn O, Newman JW, Quiding-Järbrink M, Biörserud C, Apelgren P, Staalesen T, Hagberg CE, Boucher J, Wallenius V, Lange S, Börgeson E. PMID: 35789845; PMCID: PMC9249816.
      View in: PubMed   Mentions: 4  
    6. Impaired Intracellular Ca2+ Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice. Int J Mol Sci. 2022 Jan 24; 23(3). Pierantozzi E, Szentesi P, Paolini C, Dienes B, Fodor J, Oláh T, Colombini B, Rassier DE, Rubino EM, Lange S, Rossi D, Csernoch L, Bagni MA, Reggiani C, Sorrentino V. PMID: 35163243; PMCID: PMC8835721.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles. Biophys Rev. 2021 Oct; 13(5):653-677. van der Pijl RJ, Domenighetti AA, Sheikh F, Ehler E, Ottenheijm CAC, Lange S. PMID: 34745373; PMCID: PMC8553726.
      View in: PubMed   Mentions: 8  
    8. The N2A region of titin has a unique structural configuration. J Gen Physiol. 2021 07 05; 153(7). Stronczek C, Lange S, Bullard B, Wolniak S, Börgeson E, Mayans O, Fleming JR. PMID: 33836065; PMCID: PMC8042602.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    9. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 06 01; 131(11). Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. PMID: 33857019; PMCID: PMC8159691.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students. BMC Med Educ. 2021 May 22; 21(1):294. Börgeson E, Sotak M, Kraft J, Bagunu G, Biörserud C, Lange S. PMID: 34022871; PMCID: PMC8140581.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsPHPublic Health
    11. Exploring Obscurin and SPEG Kinase Biology. J Clin Med. 2021 Mar 02; 10(5). Fleming JR, Rani A, Kraft J, Zenker S, Börgeson E, Lange S. PMID: 33801198; PMCID: PMC7957886.
      View in: PubMed   Mentions: 7  
    12. Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism. J Mol Biol. 2021 04 30; 433(9):166901. Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O. PMID: 33647290; PMCID: PMC8052292.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. Int J Mol Sci. 2020 Oct 26; 21(21). Blondelle J, Biju A, Lange S. PMID: 33114658; PMCID: PMC7672578.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    14. Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Sci Rep. 2019 10 28; 9(1):15385. Rajan MR, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton NJ, Biörserud C, Lindahl TL, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman JW, Perkins R, Wallenius V, Lange S, Börgeson E. PMID: 31659186; PMCID: PMC6817872.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    15. miR-486 is modulated by stretch and increases ventricular growth. JCI Insight. 2019 09 12; 4(19). Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V. PMID: 31513548; PMCID: PMC6795397.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    16. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol. 2019; 2:178. Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Estève E, Sorrentino V, Ghassemian M, Lange S. PMID: 31098411; PMCID: PMC6509138.
      View in: PubMed   Mentions: 11  Translation:HumansAnimalsCells
    17. Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. JCI Insight. 2019 04 16; 5. Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. PMID: 30990797; PMCID: PMC6542616.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. PKC and PKN in heart disease. J Mol Cell Cardiol. 2019 03; 128:212-226. Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S. PMID: 30742812; PMCID: PMC6408329.
      View in: PubMed   Mentions: 35     Fields:    
    19. The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res. 2020 03; 1867(3):118440. Lange S, Pinotsis N, Agarkova I, Ehler E. PMID: 30738787; PMCID: PMC7023976.
      View in: PubMed   Mentions: 42     Fields:    
    20. Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion. J Mol Cell Cardiol. 2018 08; 121:287-296. Ehsan M, Kelly M, Hooper C, Yavari A, Beglov J, Bellahcene M, Ghataorhe K, Poloni G, Goel A, Kyriakou T, Fleischanderl K, Ehler E, Makeyev E, Lange S, Ashrafian H, Redwood C, Davies B, Watkins H, Gehmlich K. PMID: 30048712; PMCID: PMC6117453.
      View in: PubMed   Mentions: 11     Fields:    
    21. Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01; 127(8):3189-3200. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. PMID: 28737513; PMCID: PMC5531406.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    22. Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. J Mol Biol. 2017 04 07; 429(7):1045-1066. Blondelle J, Shapiro P, Domenighetti AA, Lange S. PMID: 28238764; PMCID: PMC5395100.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biol. 2016 Sep; 6(9). Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. PMID: 27683155; PMCID: PMC5043576.
      View in: PubMed   Mentions: 10     Fields:    
    24. MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy. Nat Commun. 2016 06 29; 7:12120. Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E. PMID: 27353086; PMCID: PMC4931343.
      View in: PubMed   Mentions: 36     Fields:    
    25. Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015 May 05; 4(5). Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J. PMID: 25944877; PMCID: PMC4599425.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    26. Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H974-6. Blondelle J, Lange S, Greenberg BH, Cowling RT. PMID: 25747750; PMCID: PMC4578146.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    27. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling. J Mol Cell Cardiol. 2015 Feb; 79:133-44. Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V. PMID: 25446186; PMCID: PMC4302020.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    28. Probing muscle ankyrin-repeat protein (MARP) structure and function. Anat Rec (Hoboken). 2014 Sep; 297(9):1615-29. Lun AS, Chen J, Lange S. PMID: 25125175; PMCID: PMC4135402.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    29. Reply: Hereditary myopathy with early respiratory failure is caused by mutations in the titin FN3 119 domain. Brain. 2014 Jun; 137(Pt 6):e279. Lange S, Edström L, Udd B, Gautel M. PMID: 24569025; PMCID: PMC4032095.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Isolation and culture of neonatal mouse cardiomyocytes. J Vis Exp. 2013 Sep 06; (79). Ehler E, Moore-Morris T, Lange S. PMID: 24056408; PMCID: PMC3857885.
      View in: PubMed   Mentions: 100     Fields:    
    31. Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013 Oct 11; 288(41):29403-13. Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, Jiang L, Cai Y, Mu Y, Sheikh F, Ye S, Chen J, Ke Y, Cheng H. PMID: 23996002; PMCID: PMC3795241.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    32. Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med. 2013 Apr; 19(4):239-49. Lyon RC, Lange S, Sheikh F. PMID: 23453282; PMCID: PMC3622835.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    33. Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol. 2013 Feb 18; 200(4):523-36. Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, Reggiani C, Lange S, Peter AK, Chen J, Sorrentino V. PMID: 23420875; PMCID: PMC3575540.
      View in: PubMed   Mentions: 41     Fields:    
    34. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84. Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. PMID: 22778266; PMCID: PMC3436149.
      View in: PubMed   Mentions: 55     Fields:    
    35. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 2012 Jul; 23(13):2490-504. Lange S, Perera S, Teh P, Chen J. PMID: 22573887; PMCID: PMC3386213.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    36. Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 03; 110(3):456-64. Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J. PMID: 22158707; PMCID: PMC3739283.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    37. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. J Cell Biol. 2010 Dec 13; 191(6):1159-72. Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C, Ehler E. PMID: 21149568; PMCID: PMC3002041.
      View in: PubMed   Mentions: 50     Fields:    
    38. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010 Sep 27; 5(9):e13039. DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. PMID: 20885963; PMCID: PMC2946408.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    39. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15; 19(2):329-41. Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J. PMID: 19864491; PMCID: PMC2796894.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    40. Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci. 2009 Aug 01; 122(Pt 15):2640-50. Lange S, Ouyang K, Meyer G, Cui L, Cheng H, Lieber RL, Chen J. PMID: 19584095; PMCID: PMC2909316.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    41. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. PMID: 19033658; PMCID: PMC2575833.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    42. Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. J Cell Sci. 2008 Jun 01; 121(11):1841-51. Fukuzawa A, Lange S, Holt M, Vihola A, Carmignac V, Ferreiro A, Udd B, Gautel M. PMID: 18477606.
      View in: PubMed   Mentions: 67     Fields:    
    43. Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J. 2008 Jan 09; 27(1):253-64. Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M. PMID: 18059477; PMCID: PMC2206126.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008 Feb 15; 376(2):338-51. Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard JC, Agarkova I. PMID: 18177667.
      View in: PubMed   Mentions: 33     Fields:    
    45. "Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med. 2007 Nov; 17(8):258-62. Sheikh F, Bang ML, Lange S, Chen J. PMID: 18021935; PMCID: PMC2134983.
      View in: PubMed   Mentions: 26     Fields:    
    46. Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin. J Mol Biol. 2007 Aug 10; 371(2):469-80. Müller S, Lange S, Gautel M, Wilmanns M. PMID: 17574571.
      View in: PubMed   Mentions: 12     Fields:    
    47. Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol. 2006 Aug; 155(2):239-50. Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, Wilmanns M. PMID: 16713295.
      View in: PubMed   Mentions: 10     Fields:    
    48. Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature. 2006 Jan 12; 439(7073):229-33. Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M. PMID: 16407954.
      View in: PubMed   Mentions: 56     Fields:    
    49. Experimental reconstruction of a long-period grating from its core-to-core transmission spectrum. Opt Lett. 2005 Dec 15; 30(24):3272-4. Rosenthal A, Horowitz M, Lange S, Shäffer C. PMID: 16389802.
      View in: PubMed   Mentions:    Fields:    
    50. From A to Z and back? Multicompartment proteins in the sarcomere. Trends Cell Biol. 2006 Jan; 16(1):11-8. Lange S, Ehler E, Gautel M. PMID: 16337382.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    51. The kinase domain of titin controls muscle gene expression and protein turnover. Science. 2005 Jun 10; 308(5728):1599-603. Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edström L, Ehler E, Udd B, Gautel M. PMID: 15802564.
      View in: PubMed   Mentions: 207     Fields:    
    52. Dimerisation of myomesin: implications for the structure of the sarcomeric M-band. J Mol Biol. 2005 Jan 14; 345(2):289-98. Lange S, Himmel M, Auerbach D, Agarkova I, Hayess K, Fürst DO, Perriard JC, Ehler E. PMID: 15571722.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    53. The sarcomeric M-band during development and in disease. J Muscle Res Cell Motil. 2005; 26(6-8):375-9. Lange S, Agarkova I, Perriard JC, Ehler E. PMID: 16470337.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    54. The effect of curtailed hospitalization on the management and outcome of lumbar discectomy patients in a private practice setting. Conn Med. 2004 Mar; 68(3):139-45. Lange SC, Bernstein B, Lange CL, Perkins SB. PMID: 15058503.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. M-band: a safeguard for sarcomere stability? J Muscle Res Cell Motil. 2003; 24(2-3):191-203. Agarkova I, Ehler E, Lange S, Schoenauer R, Perriard JC. PMID: 14609030.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    56. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. J Cell Sci. 2002 Dec 15; 115(Pt 24):4925-36. Lange S, Auerbach D, McLoughlin P, Perriard E, Schäfer BW, Perriard JC, Ehler E. PMID: 12432079.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
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