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Stephan Lange

Title(s)Associate Adjunct Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0613C
La Jolla CA 92093
Phone8/8-22--4618
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    Collapse Biography 
    Collapse Awards and Honors
    International Society for Heart Research2014ISHR Young Investigator Award (Winner Senior Group)
    NIH2011NIH K99 Pathway to Independence Award
    2010Travel Award of the European Muscle Conference (EMC)
    2009University of San Diego Cardiovascular Scholarship Award
    2007Travel Award of the British Society of Cell Biology
    2007Travel Award of the Swiss Society of Cell Biology
    2007Poster Award of the European Muscle Conference (EMC)
    Swiss Federal Institute of Technology2006Medal of the Swiss Federal Institute of Technology
    2005Travel Award of the Weinstein Conference on Cardiovascular Development
    2005Travel Award of the British Society of Cell Biology

    Collapse Overview 
    Collapse Overview
    Dr. Lange's laboratory investigates the development and function of heart and skeletal muscles. The research focus is centered on the identification of molecular origins and pathways that lead to the development of cardiomyopathies and muscular dystrophies. We are particularly interested how mutations in sarcomeric and muscle associated proteins lead to the development of these diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Signaling Pathways in Dilated Cardiomyopathy
    NIH/NHLBI R01HL128457Aug 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    Cullin mediated protein turnover in skeletal and cardiac muscles
    NIH/NHLBI R00HL107744Apr 1, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Cullin mediated protein turnover in skeletal and cardiac muscles
    NIH/NHLBI K99HL107744Apr 1, 2011 - Mar 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. miR-486 is modulated by stretch and increases ventricular growth. JCI Insight. 2019 09 12; 4(19). Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V. PMID: 31513548.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol. 2019; 2:178. Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Estève E, Sorrentino V, Ghassemian M, Lange S. PMID: 31098411.
      View in: PubMed   Mentions:
    3. Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. JCI Insight. 2019 04 16; 5. Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. PMID: 30990797.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. PKC and PKN in heart disease. J Mol Cell Cardiol. 2019 03; 128:212-226. Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S. PMID: 30742812.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res. 2020 03; 1867(3):118440. Lange S, Pinotsis N, Agarkova I, Ehler E. PMID: 30738787.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 01; 127(8):3189-3200. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. PMID: 28737513.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    7. Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. J Mol Biol. 2017 04 07; 429(7):1045-1066. Blondelle J, Shapiro P, Domenighetti AA, Lange S. PMID: 28238764.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. MLP and CARP are linked to chronic PKCa signalling in dilated cardiomyopathy. Nat Commun. 2016 06 29; 7:12120. Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E. PMID: 27353086.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    9. Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015 May 05; 4(5). Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J. PMID: 25944877.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    10. Cathepsins in heart disease-chewing on the heartache? Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H974-6. Blondelle J, Lange S, Greenberg BH, Cowling RT. PMID: 25747750.
      View in: PubMed   Mentions:
    11. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-ß signaling. J Mol Cell Cardiol. 2015 Feb; 79:133-44. Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V. PMID: 25446186.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    12. Probing muscle ankyrin-repeat protein (MARP) structure and function. Anat Rec (Hoboken). 2014 Sep; 297(9):1615-29. Lun AS, Chen J, Lange S. PMID: 25125175.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    13. Reply: Hereditary myopathy with early respiratory failure is caused by mutations in the titin FN3 119 domain. Brain. 2014 Jun; 137(Pt 6):e279. Lange S, Edström L, Udd B, Gautel M. PMID: 24569025.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med. 2013 Apr; 19(4):239-49. Lyon RC, Lange S, Sheikh F. PMID: 23453282.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    15. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24; 287(35):29273-84. Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. PMID: 22778266.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    16. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 2012 Jul; 23(13):2490-504. Lange S, Perera S, Teh P, Chen J. PMID: 22573887.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    17. Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 03; 110(3):456-64. Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J. PMID: 22158707.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    18. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010 Sep 27; 5(9):e13039. DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. PMID: 20885963.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    19. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15; 19(2):329-41. Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J. PMID: 19864491.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    20. Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci. 2009 Aug 01; 122(Pt 15):2640-50. Lange S, Ouyang K, Meyer G, Cui L, Cheng H, Lieber RL, Chen J. PMID: 19584095.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    21. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec; 118(12):3870-80. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. PMID: 19033658.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    22. "Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med. 2007 Nov; 17(8):258-62. Sheikh F, Bang ML, Lange S, Chen J. PMID: 18021935.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
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