Alice Zemljic-harpf

Title(s)Assistant Researcher, Anesthesiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Awards and Honors
    School of Medicine, University of California, San Diego2007Schulman Award, given to a trainee, who has demonstrated groundbreaking cardiovascular research
    American Heart Association2008New Investigator Travel Award, BCVS conference, Heart Failure: Molecular and Therapeutic Targets

    Collapse Overview 
    Collapse Overview
    My research focus is to investigate molecular pathways leading to congestive heart failure and cardiac arrhythmias. Current studies address: 1) the effect of hydrophilic and lipophilic statin drugs on cardiac myocyte integrity and cardiac mitochondrial function; 2) the molecular characterization of opioid receptor activation in the heart and how the activation of specific opioid receptors may protect the heart from injury; and 3) the molecular mechanisms, safety profiles and efficacies of commonly used drugs during the onset and progression of heart failure in vivo.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription. bioRxiv. 2024 May 22. Wagner T, Priyanka P, Micheletti R, Friedman MJ, Nair SJ, Gamliel A, Taylor H, Song X, Cho M, Oh S, Li W, Han J, Ohgi KA, Abrass M, D'Antonio-Chronowska A, D'Antonio M, Hazuda H, Duggirala R, Blangero J, Ding S, Guzmann C, Frazer KA, Aggarwal AK, Zemljic-Harpf AE, Rosenfeld MG, Suh Y. PMID: 38798402; PMCID: PMC11118446.
      View in: PubMed   Mentions:
    2. Statin Use in Relation to COVID-19 and Other Respiratory Infections: Muscle and Other Considerations. J Clin Med. 2023 Jul 13; 12(14). Golomb BA, Han JH, Langsjoen PH, Dinkeloo E, Zemljic-Harpf AE. PMID: 37510774; PMCID: PMC10380486.
      View in: PubMed   Mentions: 4  
    3. E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury. Am J Physiol Regul Integr Comp Physiol. 2022 12 01; 323(6):R849-R860. Nogueira L, Zemljic-Harpf AE, Yusufi R, Ranjbar M, Susanto C, Tang K, Mahata SK, Jennings PA, Breen EC. PMID: 36250633; PMCID: PMC9678407.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    4. Molecular mechanisms of anthracycline cardiovascular toxicity. Clin Sci (Lond). 2021 05 28; 135(10):1311-1332. Narezkina A, Narayan HK, Zemljic-Harpf AE. PMID: 34047339; PMCID: PMC10866014.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    5. Morphine induces physiological, structural, and molecular benefits in the diabetic myocardium. FASEB J. 2021 03; 35(3):e21407. Zemljic-Harpf AE, See Hoe LE, Schilling JM, Zuniga-Hertz JP, Nguyen A, Vaishnav YJ, Belza GJ, Budiono BP, Patel PM, Head BP, Dillmann WH, Mahata SK, Peart JN, Roth DM, Headrick JP, Patel HH. PMID: 33583084; PMCID: PMC10843897.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Correction to: Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct. 2020 04; 225(3):1163. Takashima Y, Fannon MJ, Galinato MH, Steiner NL, An M, Zemljic-Harpf AE, Somkuwar SS, Head BP, Mandyam CD. PMID: 31938933.
      View in: PubMed   Mentions:    Fields:    
    7. Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G531-G541. Kim SY, Kim KH, Schilling JM, Leem J, Dhanani M, Head BP, Roth DM, Zemljic-Harpf AE, Patel HH. PMID: 31961720; PMCID: PMC7099497.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection. Int J Mol Sci. 2019 May 29; 20(11). Weber NC, Schilling JM, Warmbrunn MV, Dhanani M, Kerindongo R, Siamwala J, Song Y, Zemljic-Harpf AE, Fannon MJ, Hollmann MW, Preckel B, Roth DM, Patel HH. PMID: 31146391; PMCID: PMC6600664.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    9. Neuron-targeted caveolin-1 improves neuromuscular function and extends survival in SOD1G93A mice. FASEB J. 2019 06; 33(6):7545-7554. Sawada A, Wang S, Jian M, Leem J, Wackerbarth J, Egawa J, Schilling JM, Platoshyn O, Zemljic-Harpf A, Roth DM, Patel HH, Patel PM, Marsala M, Head BP. PMID: 30894019; PMCID: PMC6529340.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Metabolomic analysis of serum and myocardium in compensated heart failure after myocardial infarction. Life Sci. 2019 Mar 15; 221:212-223. McKirnan MD, Ichikawa Y, Zhang Z, Zemljic-Harpf AE, Fan S, Barupal DK, Patel HH, Hammond HK, Roth DM. PMID: 30731143; PMCID: PMC6445392.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    11. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2018 09 01; 28(9):3255-3266. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. PMID: 28981594; PMCID: PMC6095215.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    12. Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes. FASEB J. 2019 01; 33(1):1209-1225. Godoy JC, Niesman IR, Busija AR, Kassan A, Schilling JM, Schwarz A, Alvarez EA, Dalton ND, Drummond JC, Roth DM, Kararigas G, Patel HH, Zemljic-Harpf AE. PMID: 30169110; PMCID: PMC6988843.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    13. Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct. 2018 Jun; 223(5):2197-2211. Takashima Y, Fannon MJ, Galinato MH, Steiner NL, An M, Zemljic-Harpf AE, Somkuwar SS, Head BP, Mandyam CD. PMID: 29441405; PMCID: PMC5970030.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. Altered Penile Caveolin Expression in Diabetes: Potential Role in Erectile Dysfunction. J Sex Med. 2017 10; 14(10):1177-1186. Parikh J, Zemljic-Harpf A, Fu J, Giamouridis D, Hsieh TC, Kassan A, Murthy KS, Bhargava V, Patel HH, Rajasekaran MR. PMID: 28923309; PMCID: PMC5802868.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    15. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. PMID: 28498861; PMCID: PMC5428970.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 08; 31(8):3403-3411. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. PMID: 28450301; PMCID: PMC5503707.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016 May; 111(3):28. Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. PMID: 27023865; PMCID: PMC5336321.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 01; 267:6-11. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. PMID: 24657594; PMCID: PMC4059187.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    19. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014 Mar 01; 127(Pt 5):1104-16. Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross RS. PMID: 24413171; PMCID: PMC3937777.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    20. Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol. 2013 Jul 08; 202(1):163-77. Thievessen I, Thompson PM, Berlemont S, Plevock KM, Plotnikov SV, Zemljic-Harpf A, Ross RS, Davidson MW, Danuser G, Campbell SL, Waterman CM. PMID: 23836933; PMCID: PMC3704983.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    21. Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells. Glia. 2013 Jul; 61(7):1067-83. Winkler U, Hirrlinger PG, Sestu M, Wilhelm F, Besser S, Zemljic-Harpf AE, Ross RS, Bornschein G, Krügel U, Ziegler WH, Hirrlinger J. PMID: 23595642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. PMID: 23561539; PMCID: PMC3617425.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    23. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. PMID: 20981782; PMCID: PMC3272305.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    24. What is vinculin needed for in platelets? J Thromb Haemost. 2010 Oct; 8(10):2294-304. Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ. PMID: 20670372; PMCID: PMC2965783.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    25. Vinculin and talin: focus on the myocardium. J Investig Med. 2009 Dec; 57(8):849-55. Zemljic-Harpf A, Manso AM, Ross RS. PMID: 19952892; PMCID: PMC2810504.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    26. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS. PMID: 17785437; PMCID: PMC2169049.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    27. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. Oh YS, Jong AY, Kim DT, Li H, Wang C, Zemljic-Harpf A, Ross RS, Fishbein MC, Chen PS, Chen LS. PMID: 16731479.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    28. Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol. 2004 Sep; 165(3):1033-44. Zemljic-Harpf AE, Ponrartana S, Avalos RT, Jordan MC, Roos KP, Dalton ND, Phan VQ, Adamson ED, Ross RS. PMID: 15331426; PMCID: PMC1618594.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    29. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines. Circulation. 2002 Dec 10; 106(24):3024-30. Uzui H, Harpf A, Liu M, Doherty TM, Shukla A, Chai NN, Tripathi PV, Jovinge S, Wilkin DJ, Asotra K, Shah PK, Rajavashisth TB. PMID: 12473546.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    30. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem Cell Biol. 2002 Dec; 118(6):431-9. Babbitt CJ, Shai SY, Harpf AE, Pham CG, Ross RS. PMID: 12483308.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    31. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 08; 90(4):458-64. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross RS. PMID: 11884376.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    32. Integrins and the myocardium. Genet Eng (N Y). 2002; 24:87-105. Shai SY, Harpf AE, Ross RS. PMID: 12416302.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    33. Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H2916-26. Pham CG, Harpf AE, Keller RS, Vu HT, Shai SY, Loftus JC, Ross RS. PMID: 11087248.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
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