Loading...

Alice Zemljic-Harpf

TitleAssistant Researcher
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address9500 Gilman Drive #9151
La Jolla CA 92093
Phone858-552-8585
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    School of Medicine, University of California, San Diego2007Schulman Award, given to a trainee, who has demonstrated groundbreaking cardiovascular research
    American Heart Association2008New Investigator Travel Award, BCVS conference, Heart Failure: Molecular and Therapeutic Targets

    Collapse Overview 
    Collapse Overview
    My research focus is to investigate molecular pathways leading to congestive heart failure and cardiac arrhythmias. Further, commonly used drugs and their safety profiles are studied in vitro as well as in vivo, before and after the onset of heat failure.


    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Takashima Y, Fannon MJ, Galinato MH, Steiner NL, An M, Zemljic-Harpf AE, Somkuwar SS, Head BP, Mandyam CD. Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct. 2018 Feb 13. PMID: 29441405.
      View in: PubMed
    2. Parikh J, Zemljic-Harpf A, Fu J, Giamouridis D, Hsieh TC, Kassan A, Murthy KS, Bhargava V, Patel HH, Rajasekaran MR. Altered Penile Caveolin Expression in Diabetes: Potential Role in Erectile Dysfunction. J Sex Med. 2017 Oct; 14(10):1177-1186. PMID: 28923309.
      View in: PubMed
    3. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2017 Jul 31; 1-12. PMID: 28981594.
      View in: PubMed
    4. Ichikawa Y, Zemljic-Harpf AE, Zhang Z, McKirnan MD, Manso AM, Ross RS, Hammond HK, Patel HH, Roth DM. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. PLoS One. 2017; 12(5):e0177660. PMID: 28498861.
      View in: PubMed
    5. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 08; 31(8):3403-3411. PMID: 28450301.
      View in: PubMed
    6. Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016 May; 111(3):28. PMID: 27023865.
      View in: PubMed
    7. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res. 2014 Jul 01; 267:6-11. PMID: 24657594; PMCID: PMC4059187.
    8. Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross RS. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014 Mar 01; 127(Pt 5):1104-16. PMID: 24413171; PMCID: PMC3937777.
    9. Thievessen I, Thompson PM, Berlemont S, Plevock KM, Plotnikov SV, Zemljic-Harpf A, Ross RS, Davidson MW, Danuser G, Campbell SL, Waterman CM. Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol. 2013 Jul 08; 202(1):163-77. PMID: 23836933; PMCID: PMC3704983.
    10. Winkler U, Hirrlinger PG, Sestu M, Wilhelm F, Besser S, Zemljic-Harpf AE, Ross RS, Bornschein G, Kr├╝gel U, Ziegler WH, Hirrlinger J. Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells. Glia. 2013 Jul; 61(7):1067-83. PMID: 23595642.
      View in: PubMed
    11. Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophys J. 2013 Apr 02; 104(7):1623-33. PMID: 23561539; PMCID: PMC3617425.
    12. Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magn Reson Med. 2010 Nov; 64(5):1281-8. PMID: 20981782; PMCID: PMC3272305.
    13. Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ. What is vinculin needed for in platelets? J Thromb Haemost. 2010 Oct; 8(10):2294-304. PMID: 20670372; PMCID: PMC2965783.
    14. Zemljic-Harpf A, Manso AM, Ross RS. Vinculin and talin: focus on the myocardium. J Investig Med. 2009 Dec; 57(8):849-55. PMID: 19952892; PMCID: PMC2810504.
    15. Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol. 2007 Nov; 27(21):7522-37. PMID: 17785437; PMCID: PMC2169049.
    16. Oh YS, Jong AY, Kim DT, Li H, Wang C, Zemljic-Harpf A, Ross RS, Fishbein MC, Chen PS, Chen LS. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. PMID: 16731479.
      View in: PubMed
    17. Zemljic-Harpf AE, Ponrartana S, Avalos RT, Jordan MC, Roos KP, Dalton ND, Phan VQ, Adamson ED, Ross RS. Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol. 2004 Sep; 165(3):1033-44. PMID: 15331426; PMCID: PMC1618594.
    18. Uzui H, Harpf A, Liu M, Doherty TM, Shukla A, Chai NN, Tripathi PV, Jovinge S, Wilkin DJ, Asotra K, Shah PK, Rajavashisth TB. Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines. Circulation. 2002 Dec 10; 106(24):3024-30. PMID: 12473546.
      View in: PubMed
    19. Babbitt CJ, Shai SY, Harpf AE, Pham CG, Ross RS. Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle. Histochem Cell Biol. 2002 Dec; 118(6):431-9. PMID: 12483308.
      View in: PubMed
    20. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross RS. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 08; 90(4):458-64. PMID: 11884376.
      View in: PubMed
    21. Shai SY, Harpf AE, Ross RS. Integrins and the myocardium. Genet Eng (N Y). 2002; 24:87-105. PMID: 12416302.
      View in: PubMed
    22. Pham CG, Harpf AE, Keller RS, Vu HT, Shai SY, Loftus JC, Ross RS. Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H2916-26. PMID: 11087248.
      View in: PubMed
    Alice's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _