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Chitra Mandyam

Title(s)Associate Adjunct Professor, Anesthesiology
SchoolHealth Sciences
Address9500 Gilman Drive #9151
La Jolla CA 92093
Phone858-552-8585
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    Collapse Biography 
    Collapse Education and Training
    University of Houston, Houston TXPhDNeuropharmacology
    UT Southwestern Medical Center, Dallas TXPostdocNeuroscience
    Scripps Research Institute, La Jolla CAPostdocNeuropsychopharmacology
    Collapse Awards and Honors
    National Institute on Drug Abuse2001National Research Service Award
    University of Houston, Sigma Xi chapter2001Graduate Student Research Achievement Award
    International Narcotics Research Conference 2001Travel Award
    VolkswagenStiftung2002Travel Award (Route28 summits in neurobiology)
    National Institute on Drug Abuse2003National Research Service Award
    National Institute on Drug Abuse2007Career Development Award
    American College of Neuropsychopharmacology2011Young Investigator Travel Award
    American College of Neuropsychopharmacology2018Member

    Collapse Overview 
    Collapse Overview
    Research Goals
    Our laboratory incorporates innovative experiments to elucidate important issues that are of high importance to the addiction and adult neurogenesis fields. The general goal of our laboratory is to understand the relationship between brain structure and function using state-of-the-art molecular and cellular approaches to study high-level mental functions such as drug taking and seeking (which are the purview of behavioral and cognitive neuroscience). We employ genetic, pharmacological and histochemical techniques, and behavioral paradigms for understanding the role of newly born neurons and myelinating oligodendrocytes in drug pathology. The specific research theme of our laboratory is to determine the functional significance of adult neurogenesis and gliogenesis in addiction and addictive disorders. Our research is focused around two areas of inquiry:1) the role of stem cells in drug neuropathology and 2) novel neuroprotective strategies in addictive disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Caveolins, Striatal Toxicity and Methamphetamine Addiction
    NIH I01BX003304Jun 1, 2017 - May 31, 2021
    Role: Principal Investigator
    Methamphetamine and adult hippocampal neurogenesis
    NIH R01DA034140Jul 1, 2013 - Mar 31, 2020
    Role: PI
    Medial Prefrontal Cortical Gliogenesis and Alcohol Dependence
    NIH R01AA020098Sep 25, 2012 - Aug 31, 2023
    Role: PI

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Plasticity in the Hippocampus, Neurogenesis and Drugs of Abuse. Brain Sci. 2021 Mar 22; 11(3). Avchalumov Y, Mandyam CD. PMID: 33810204.
      View in: PubMed   Mentions:
    2. Synaptic Plasticity and its Modulation by Alcohol. Brain Plast. 2020 Dec 29; 6(1):103-111. Avchalumov Y, Mandyam CD. PMID: 33680849.
      View in: PubMed   Mentions:
    3. Acute Ethanol Exposure Enhances Synaptic Plasticity in the Dorsal Striatum in Adult Male and Female Rats. Brain Plast. 2020 Dec 29; 6(1):113-122. Avchalumov Y, Piña-Crespo JC, Woodward JJ, Mandyam CD. PMID: 33680850.
      View in: PubMed   Mentions:
    4. Chronic ethanol exposure differentially alters neuronal function in the medial prefrontal cortex and dentate gyrus. Neuropharmacology. 2020 Dec 14; 108438. Avchalumov Y, Oliver RJ, Trenet W, Heyer Osorno RE, Sibley BD, Purohit DC, Contet C, Roberto M, Woodward JJ, Mandyam CD. PMID: 33333103.
      View in: PubMed   Mentions:    Fields:    
    5. Abstinence from ethanol dependence produces concomitant cortical gray matter abnormalities, microstructural deficits and cognitive dysfunction. Eur Neuropsychopharmacol. 2020 Dec 02. Somkuwar SS, Villalpando EG, Quach LW, Head BP, McKenna BS, Scadeng M, Mandyam CD. PMID: 33279357.
      View in: PubMed   Mentions:    Fields:    
    6. SCH23390 Reduces Methamphetamine Self-Administration and Prevents Methamphetamine-Induced Striatal LTD. Int J Mol Sci. 2020 Sep 05; 21(18). Avchalumov Y, Trenet W, Piña-Crespo J, Mandyam C. PMID: 32899459.
      View in: PubMed   Mentions:    Fields:    
    7. A Novel Sulfonamide, 4-FS, Reduces Ethanol Drinking and Physical Withdrawal Associated With Ethanol Dependence. Int J Mol Sci. 2020 Jun 21; 21(12). Sona Khan M, Trenet W, Xing N, Sibley B, Abbas M, Al-Rashida M, Rauf K, Mandyam CD. PMID: 32575871.
      View in: PubMed   Mentions: 2     Fields:    
    8. In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats. Brain Struct Funct. 2020 Apr; 225(3):1073-1088. Kreisler AD, Terranova MJ, Somkuwar SS, Purohit DC, Wang S, Head BP, Mandyam CD. PMID: 32246242.
      View in: PubMed   Mentions: 1     Fields:    
    9. Correction to: Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct. 2020 04; 225(3):1163. Takashima Y, Fannon MJ, Galinato MH, Steiner NL, An M, Zemljic-Harpf AE, Somkuwar SS, Head BP, Mandyam CD. PMID: 31938933.
      View in: PubMed   Mentions:    Fields:    
    10. Individual Differences in Ethanol Drinking and Seeking Behaviors in Rats Exposed to Chronic Intermittent Ethanol Vapor Exposure is Associated with Altered CaMKII Autophosphorylation in the Nucleus Accumbens Shell. Brain Sci. 2019 Dec 11; 9(12). Somkuwar SS, Mandyam CD. PMID: 31835746.
      View in: PubMed   Mentions:
    11. Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration. Brain Sci. 2019 Nov 19; 9(11). Oliver RJ, Purohit DC, Kharidia KM, Mandyam CD. PMID: 31752398.
      View in: PubMed   Mentions:
    12. Voluntary wheel running during adolescence distinctly alters running output in adulthood in male and female rats. Behav Brain Res. 2020 01 13; 377:112235. Purohit DC, Mandyam AD, Terranova MJ, Mandyam CD. PMID: 31521739.
      View in: PubMed   Mentions:    Fields:    
    13. Sex Differences in Context-Driven Reinstatement of Methamphetamine Seeking is Associated with Distinct Neuroadaptations in the Dentate Gyrus. Brain Sci. 2018 Nov 28; 8(12). Takashima Y, Tseng J, Fannon MJ, Purohit DC, Quach LW, Terranova MJ, Kharidia KM, Oliver RJ, Mandyam CD. PMID: 30487415.
      View in: PubMed   Mentions:
    14. Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders. Front Neurosci. 2018; 12:849. Oliver RJ, Mandyam CD. PMID: 30524229.
      View in: PubMed   Mentions:
    15. Hippocampal neural progenitor cells play a distinct role in fear memory retrieval in male and female CIE rats. Neuropharmacology. 2018 12; 143:239-249. Fannon MJ, Mysore KK, Williams J, Quach LW, Purohit DC, Sibley BD, Sage-Sepulveda JS, Kharidia KM, Morales Silva RJ, Terranova MJ, Somkuwar SS, Staples MC, Mandyam CD. PMID: 30273595.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2018 09 01; 28(9):3255-3266. Egawa J, Zemljic-Harpf A, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. PMID: 28981594.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. The role of hippocampal adult neurogenesis in methamphetamine addiction. Brain Plast. 2018 Aug 10; 3(2):157-168. Takashima Y, Mandyam CD. PMID: 30151340.
      View in: PubMed   Mentions:
    18. Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. Brain Sci. 2018 Jun 26; 8(7). Somkuwar SS, Quach LW, Quigley JA, Purohit DC, Fannon MJ, Koob GF, Mandyam CD. PMID: 29949891.
      View in: PubMed   Mentions:
    19. New Neurons in the Dentate Gyrus Promote Reinstatement of Methamphetamine Seeking. J Exp Neurosci. 2018; 12:1179069518779625. Mandyam CD, Somkuwar SS, Oliver RJ, Takashima Y. PMID: 29899665.
      View in: PubMed   Mentions:
    20. Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates. Prog Neuropsychopharmacol Biol Psychiatry. 2018 07 13; 85:46-53. Dutta RR, Taffe MA, Mandyam CD. PMID: 29601895.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits. Br J Anaesth. 2018 Apr; 120(4):745-760. Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. PMID: 29576115.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct. 2018 Jun; 223(5):2197-2211. Takashima Y, Fannon MJ, Galinato MH, Steiner NL, An M, Zemljic-Harpf AE, Somkuwar SS, Head BP, Mandyam CD. PMID: 29441405.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Neurogenesis during Abstinence Is Necessary for Context-Driven Methamphetamine-Related Memory. J Neurosci. 2018 02 21; 38(8):2029-2042. Galinato MH, Takashima Y, Fannon MJ, Quach LW, Morales Silva RJ, Mysore KK, Terranova MJ, Dutta RR, Ostrom RW, Somkuwar SS, Mandyam CD. PMID: 29363584.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    24. Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders. Brain Sci. 2017 Oct 16; 7(10). Mandyam CD, Villalpando EG, Steiner NL, Quach LW, Fannon MJ, Somkuwar SS. PMID: 29035306.
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    25. Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice. Br J Anaesth. 2017 Sep 01; 119(3):465-471. Schilling JM, Kassan A, Mandyam C, Pearn ML, Voong A, Grogman GG, Risbrough VB, Niesman IR, Patel HH, Patel PM, Head BP. PMID: 28969308.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    26. Hyper-oligodendrogenesis at the vascular niche and reduced blood-brain barrier integrity in the prefrontal cortex during protracted abstinence. Neuroscience. 2017 Oct 24; 362:265-271. Somkuwar SS, Fannon MJ, Bao Nguyen T, Mandyam CD. PMID: 28870701.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors. Psychoneuroendocrinology. 2017 Oct; 84:17-31. Somkuwar SS, Vendruscolo LF, Fannon MJ, Schmeichel BE, Nguyen TB, Guevara J, Sidhu H, Contet C, Zorrilla EP, Mandyam CD. PMID: 28647675.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    28. Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 2017 08; 31(8):3403-3411. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. PMID: 28450301.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Mol Psychiatry. 2018 03; 23(3):629-638. Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD. PMID: 28348387.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Dietary restriction reduces hippocampal neurogenesis and granule cell neuron density without affecting the density of mossy fibers. Brain Res. 2017 05 15; 1663:59-65. Staples MC, Fannon MJ, Mysore KK, Dutta RR, Ongjoco AT, Quach LW, Kharidia KM, Somkuwar SS, Mandyam CD. PMID: 28284897.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    31. Thinking after Drinking: Impaired Hippocampal-Dependent Cognition in Human Alcoholics and Animal Models of Alcohol Dependence. Front Psychiatry. 2016; 7:162. Staples MC, Mandyam CD. PMID: 27746746.
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    32. Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex. Brain Behav Immun. 2016 Nov; 58:357-368. Somkuwar SS, Fannon-Pavlich MJ, Ghofranian A, Quigley JA, Dutta RR, Galinato MH, Mandyam CD. PMID: 27542327.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. Methamphetamine reduces expression of caveolin-1 in the dorsal striatum: Implication for dysregulation of neuronal function. Neuroscience. 2016 07 22; 328:147-56. Somkuwar SS, Fannon MJ, Head BP, Mandyam CD. PMID: 27138644.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    34. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. Brain Struct Funct. 2016 12; 221(9):4319-4335. Somkuwar SS, Fannon MJ, Staples MC, Zamora-Martinez ER, Navarro AI, Kim A, Quigley JA, Edwards S, Mandyam CD. PMID: 26659122.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    35. Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior. Brain Plast. 2015 Oct 09; 1(1):63-81. Somkuwar SS, Staples MC, Fannon MJ, Ghofranian A, Mandyam CD. PMID: 29765835.
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    36. Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry. 2017 01 15; 81(2):101-110. Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. PMID: 26592463.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    37. Developmental effects of wheel running on hippocampal glutamate receptor expression in young and mature adult rats. Neuroscience. 2015 Oct 01; 305:248-56. Staples MC, Somkuwar SS, Mandyam CD. PMID: 26220171.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    38. Brain pathways to recovery from alcohol dependence. Alcohol. 2015 Aug; 49(5):435-52. Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV. PMID: 26074423.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    39. Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. Mol Cell Neurosci. 2015 Mar; 65:153-62. Staples MC, Kim A, Mandyam CD. PMID: 25769285.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    40. Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. Neuroscience. 2015 May 07; 293:35-44. Navarro AI, Mandyam CD. PMID: 25732140.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    41. Role of NG2 expressing cells in addiction: a new approach for an old problem. Front Pharmacol. 2014; 5:279. Somkuwar SS, Staples MC, Galinato MH, Fannon MJ, Mandyam CD. PMID: 25566075.
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    42. Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. 2015 Feb 12; 286:97-108. Galinato MH, Orio L, Mandyam CD. PMID: 25463524.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    43. Chronic wheel running-induced reduction of extinction and reinstatement of methamphetamine seeking in methamphetamine dependent rats is associated with reduced number of periaqueductal gray dopamine neurons. Brain Struct Funct. 2016 Jan; 221(1):261-76. Sobieraj JC, Kim A, Fannon MJ, Mandyam CD. PMID: 25273280.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    44. Methamphetamine affects cell proliferation in the medial prefrontal cortex: a new niche for toxicity. Pharmacol Biochem Behav. 2014 Nov; 126:90-6. Kim A, Mandyam CD. PMID: 25260424.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology (Berl). 2015 Jan; 232(2):453-63. Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. PMID: 25059540.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    46. Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. Brain Struct Funct. 2015; 220(3):1705-20. Kim A, Zamora-Martinez ER, Edwards S, Mandyam CD. PMID: 24667898.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    47. The Interplay between the Hippocampus and Amygdala in Regulating Aberrant Hippocampal Neurogenesis during Protracted Abstinence from Alcohol Dependence. Front Psychiatry. 2013; 4:61. Mandyam CD. PMID: 23818882.
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    48. The role of dentate gyrus neurogenesis in neuropsychiatric disorders. Neural Plast. 2013; 2013:584382. García-Fuster MJ, Rhodes JS, Mandyam CD. PMID: 23864960.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. µ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche. Addict Biol. 2014 Sep; 19(5):770-80. Contet C, Kim A, Le D, Iyengar SK, Kotzebue RW, Yuan CJ, Kieffer BL, Mandyam CD. PMID: 23461397.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    50. Chronic wheel running reduces maladaptive patterns of methamphetamine intake: regulation by attenuation of methamphetamine-induced neuronal nitric oxide synthase. Brain Struct Funct. 2014 Mar; 219(2):657-72. Engelmann AJ, Aparicio MB, Kim A, Sobieraj JC, Yuan CJ, Grant Y, Mandyam CD. PMID: 23443965.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    51. Hippocampal neurogenesis protects against cocaine-primed relapse. Addict Biol. 2014 Jul; 19(4):562-74. Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. PMID: 23278919.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    52. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18156-61. George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. PMID: 23071333.
      View in: PubMed   Mentions: 95     Fields:    Translation:Animals
    53. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends Neurosci. 2012 Apr; 35(4):250-60. Mandyam CD, Koob GF. PMID: 22265158.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    54. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012 Apr; 37(5):1275-87. Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. PMID: 22205547.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    55. Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle. Pharmacol Biochem Behav. 2011 Nov; 100(1):98-108. Yuan CJ, Quiocho JM, Kim A, Wee S, Mandyam CD. PMID: 21855565.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    56. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11104-9. Taffe MA, Kotzebue RW, Crean RD, Crawford EF, Edwards S, Mandyam CD. PMID: 20534463.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    57. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiol Dis. 2009 Oct; 36(1):1-10. Richardson HN, Chan SH, Crawford EF, Lee YK, Funk CK, Koob GF, Mandyam CD. PMID: 19501165.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    58. Time course of morphine's effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons. Neuroscience. 2008 Nov 11; 157(1):70-9. Arguello AA, Harburg GC, Schonborn JR, Mandyam CD, Yamaguchi M, Eisch AJ. PMID: 18832014.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    59. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry. 2008 Dec 01; 64(11):958-65. Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. PMID: 18490002.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    60. Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Dev Neurobiol. 2008 Apr; 68(5):575-89. Mandyam CD, Crawford EF, Eisch AJ, Rivier CL, Richardson HN. PMID: 18264994.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    61. The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol. 2007 Dec 20; 7:16. Bawa-Khalfe T, Altememi GF, Mandyam CD, Schwarz LA, Eikenburg DC, Standifer KM. PMID: 18096057.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    62. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology. 2008 Sep; 33(10):2474-82. George O, Mandyam CD, Wee S, Koob GF. PMID: 18033234.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    63. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci. 2007 Nov 14; 27(46):12623-9. Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD, Eisch AJ. PMID: 18003841.
      View in: PubMed   Mentions: 202     Fields:    Translation:AnimalsCells
    64. Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. Eur Neuropsychopharmacol. 2008 Apr; 18(4):303-11. Wee S, Mandyam CD, Lekic DM, Koob GF. PMID: 17920248.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    65. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J Neurosci. 2007 Oct 17; 27(42):11442-50. Mandyam CD, Wee S, Eisch AJ, Richardson HN, Koob GF. PMID: 17942739.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    66. Adult neurogenesis: can analysis of cell cycle proteins move us "Beyond BrdU"? Curr Pharm Biotechnol. 2007 Jun; 8(3):147-65. Eisch AJ, Mandyam CD. PMID: 17584088.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    67. Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone. Neuroscience. 2007 Apr 25; 146(1):108-22. Mandyam CD, Harburg GC, Eisch AJ. PMID: 17307295.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    68. Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 2007 Jan; 134(2):285-93. Battiste J, Helms AW, Kim EJ, Savage TK, Lagace DC, Mandyam CD, Eisch AJ, Miyoshi G, Johnson JE. PMID: 17166924.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    69. Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology. 2006 May; 147(5):2506-17. Richardson HN, Zorrilla EP, Mandyam CD, Rivier CL. PMID: 16455779.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    70. Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone. J Neurosci Res. 2004 Jun 15; 76(6):783-94. Mandyam CD, Norris RD, Eisch AJ. PMID: 15160390.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    71. Drug dependence and addiction, II: Adult neurogenesis and drug abuse. Am J Psychiatry. 2004 Mar; 161(3):426. Eisch AJ, Mandyam CD. PMID: 14992964.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    72. Mu-opioid-induced desensitization of opioid receptor-like 1 and mu-opioid receptors: differential intracellular signaling determines receptor sensitivity. J Pharmacol Exp Ther. 2003 Sep; 306(3):965-72. Mandyam CD, Thakker DR, Standifer KM. PMID: 12750434.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    73. Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002 Aug; 302(2):502-9. Mandyam CD, Thakker DR, Christensen JL, Standifer KM. PMID: 12130708.
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    74. Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells. Neurosci Lett. 2001 Feb 23; 299(3):173-6. Mathis JP, Mandyam CD, Altememi GF, Pasternak GW, Standifer KM. PMID: 11165763.
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    75. beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells. Eur J Pharmacol. 2000 Aug 18; 402(1-2):R1-37. Mandyam CD, Altememi GF, Standifer KM. PMID: 10940375.
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