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Gourisankar Ghosh

Title(s)Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    ASF/SF2: Phosphorylation and RNA Binding
    NIH/NIGMS R01GM084277Aug 10, 2009 - Jul 31, 2013
    Role: Principal Investigator
    IKK:Biophysical basis of dynamic regulation
    NIH/NCI R01CA141722Jul 1, 2009 - May 31, 2014
    Role: Principal Investigator
    Investigation of gene regulation by NF-kappaB transcription factors
    NIH/NIGMS R01GM085490Jul 1, 2009 - Oct 30, 2013
    Role: Principal Investigator
    IkB/NF-kB Recognition in Silico, In Vitro and In Vivo
    NIH/NIGMS P01GM071862Apr 7, 2006 - Mar 31, 2012
    Role: Co-Investigator
    NF-kB regulation by p105 and p100
    NIH/NIAID R01AI064326Feb 15, 2005 - Jan 31, 2011
    Role: Principal Investigator
    MECHANISM OF TRANSCRIPTIONAL INHIBITION BY IKB PROTEINS
    NIH/NCI R01CA078749Apr 1, 1999 - Mar 31, 2003
    Role: Principal Investigator
    Structure/Function Studies of Nuclear FActor KB
    NIH/NCI R01CA071871Sep 5, 1996 - Oct 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution. Biochim Biophys Acta Proteins Proteom. 2020 Aug 24; 140526. Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T. PMID: 32853772.
      View in: PubMed   Mentions:    Fields:    
    2. Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing. Nucleic Acids Res. 2020 06 19; 48(11):6294-6309. Saha K, England W, Fernandez MM, Biswas T, Spitale RC, Ghosh G. PMID: 32402057.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Genome reading by the NF-?B transcription factors. Nucleic Acids Res. 2019 11 04; 47(19):9967-9989. Mulero MC, Wang VY, Huxford T, Ghosh G. PMID: 31501881.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. NF-?B, I?B, and IKK: Integral Components of Immune System Signaling. Adv Exp Med Biol. 2019; 1172:207-226. Mulero MC, Huxford T, Ghosh G. PMID: 31628658.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. A Guide to Production, Crystallization, and Structure Determination of Human IKK1/a. J Vis Exp. 2018 11 02; (141). Polley S, Huang DB, Biswas T, Ghosh G. PMID: 30451218.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor ?B RelA Subunit. Biochemistry. 2018 05 22; 57(20):2943-2957. Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang DB, Wang VY, Amaro RE, Huxford T, Ghosh G. PMID: 29708732.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor ?B are not correlated. J Biol Chem. 2017 11 17; 292(46):18821-18830. Mulero MC, Huang DB, Nguyen HT, Wang VY, Li Y, Biswas T, Ghosh G. PMID: 28935669.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity. Mol Cell. 2017 Aug 03; 67(3):484-497.e5. Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G. PMID: 28689659.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Structural Basis for the Activation of IKK1/a. Cell Rep. 2016 11 15; 17(8):1907-1914. Polley S, Passos DO, Huang DB, Mulero MC, Mazumder A, Biswas T, Verma IM, Lyumkis D, Ghosh G. PMID: 27851956.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    10. The NF-?B subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100. Sci Signal. 2016 09 27; 9(447):ra96. Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. PMID: 27678221.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. To Swap or Not To Swap. Structure. 2016 09 06; 24(9):1436-8. Ghosh G, Biswas T. PMID: 27602989.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity. Mol Cell. 2016 08 18; 63(4):544-546. Ghosh G, Sen M. PMID: 27540854.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. I?Bß enhances the generation of the low-affinity NF?B/RelA homodimer. Nat Commun. 2015 May 07; 6:7068. Tsui R, Kearns JD, Lynch C, Vu D, Ngo KA, Basak S, Ghosh G, Hoffmann A. PMID: 25946967.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    14. p100/I?Bd sequesters and inhibits NF-?B through kappaBsome formation. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15946-51. Tao Z, Fusco A, Huang DB, Gupta K, Young Kim D, Ware CF, Van Duyne GD, Ghosh G. PMID: 25349408.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J. 2014 Aug 15; 462(1):143-52. Aubol BE, Plocinik RM, Keshwani MM, McGlone ML, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 24869919.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-?B-driven transcription. PLoS Biol. 2013 Sep; 11(9):e1001647. Mukherjee SP, Behar M, Birnbaum HA, Hoffmann A, Wright PE, Ghosh G. PMID: 24019758.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    17. A structural basis for I?B kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 2013; 11(6):e1001581. Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schröfelbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. PMID: 23776406.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    18. A structural basis for selective dimerization by NF-?B RelB. J Mol Biol. 2013 Jun 12; 425(11):1934-1945. Vu D, Huang DB, Vemu A, Ghosh G. PMID: 23485337.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. The transcriptional specificity of NF-?B dimers is coded within the ?B DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. PMID: 23063365.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    20. Understanding NIK regulation from its structure. Structure. 2012 Oct 10; 20(10):1615-7. Tao Z, Ghosh G. PMID: 23063006.
      View in: PubMed   Mentions: 1     Fields:    
    21. NEMO ensures signaling specificity of the pleiotropic IKKß by directing its kinase activity toward I?Ba. Mol Cell. 2012 Jul 13; 47(1):111-21. Schröfelbauer B, Polley S, Behar M, Ghosh G, Hoffmann A. PMID: 22633953.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    22. NF-?B regulation: lessons from structures. Immunol Rev. 2012 Mar; 246(1):36-58. Ghosh G, Wang VY, Huang DB, Fusco A. PMID: 22435546.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    23. The SRSF1 linker induces semi-conservative ESE binding by cooperating with the RRMs. Nucleic Acids Res. 2011 Nov; 39(21):9413-21. Cho S, Hoang A, Chakrabarti S, Huynh N, Huang DB, Ghosh G. PMID: 21852328.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    24. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8233-8. Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. PMID: 21536904.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    25. Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase. J Cell Biol. 2011 Apr 04; 193(1):41-50. Chawla A, Chakrabarti S, Ghosh G, Niwa M. PMID: 21444691.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    26. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-?B p50. Sci Signal. 2011 Feb 22; 4(161):ra11. Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. PMID: 21343618.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    27. NF-?B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15; 6(2):e16815. Ho JQ, Asagiri M, Hoffmann A, Ghosh G. PMID: 21347231.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    28. Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J. 2011 Feb; 278(4):587-97. Ghosh G, Adams JA. PMID: 21205204.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    29. Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol. 2010 Oct 29; 403(3):386-404. Ma CT, Ghosh G, Fu XD, Adams JA. PMID: 20826166.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    30. Flexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal. J Biol Chem. 2010 Oct 22; 285(43):32927-36. Mathes E, Wang L, Komives E, Ghosh G. PMID: 20682784.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    31. Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1. Biochemistry. 2009 Dec 08; 48(48):11432-40. Huynh N, Ma CT, Giang N, Hagopian J, Ngo J, Adams J, Ghosh G. PMID: 19886675.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    32. Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19328-33. Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G, Komives EA. PMID: 19887633.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    33. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell. 2009 Jun 12; 34(5):591-602. Savinova OV, Hoffmann A, Ghosh G. PMID: 19524538.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    34. Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9619-24. Shih VF, Kearns JD, Basak S, Savinova OV, Ghosh G, Hoffmann A. PMID: 19487661.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    35. Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One. 2009; 4(3):e4746. Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. PMID: 19270744.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    36. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009 Feb 15; 23(4):482-95. Zhong XY, Ding JH, Adams JA, Ghosh G, Fu XD. PMID: 19240134.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    37. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem. 2009 Mar 06; 284(10):6241-8. Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. PMID: 19122195.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    38. NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes. . 2009 Feb; 10(2):152-9. Fusco AJ, Huang DB, Miller D, Wang VY, Vu D, Ghosh G. PMID: 19098713.
      View in: PubMed   Mentions:
    39. The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. Protein Sci. 2008 Dec; 17(12):2051-8. Bergqvist S, Ghosh G, Komives EA. PMID: 18824506.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    40. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2008 Oct 17; 382(4):894-909. Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings PA, Fu XD, Adams JA. PMID: 18687337.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    41. NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J. 2008 May 07; 27(9):1357-67. Mathes E, O'Dea EL, Hoffmann A, Ghosh G. PMID: 18401342.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    42. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell. 2008 Mar 14; 29(5):563-76. Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G. PMID: 18342604.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    43. Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J Mol Biol. 2008 Jun 27; 380(1):67-82. Truhlar SM, Mathes E, Cervantes CF, Ghosh G, Komives EA. PMID: 18511071.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    44. Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem. 2008 May 02; 283(18):12324-32. Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G. PMID: 18321863.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    45. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. J Biol Chem. 2008 Jan 11; 283(2):1084-93. Kennedy EJ, Ghosh G, Pillus L. PMID: 17971450.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    46. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 2007 Oct 30; 46(43):12482-90. Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. PMID: 17924664.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    47. X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. J Mol Biol. 2007 Oct 26; 373(3):723-34. Moorthy AK, Huang DB, Wang VY, Vu D, Ghosh G. PMID: 17869269.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    48. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. J Mol Biol. 2008 Feb 08; 376(1):55-68. Ma CT, Velazquez-Dones A, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 18155240.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    49. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007 Aug 10; 282(32):23036-43. Lukasiewicz R, Velazquez-Dones A, Huynh N, Hagopian J, Fu XD, Adams J, Ghosh G. PMID: 17517895.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    50. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 2007 Jan 26; 128(2):369-81. Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. PMID: 17254973.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    51. SR protein kinase 1 is resilient to inactivation. Structure. 2007 Jan; 15(1):123-33. Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G. PMID: 17223538.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    52. The RGG domain of Npl3p recruits Sky1p through docking interactions. J Mol Biol. 2007 Mar 16; 367(1):249-61. Lukasiewicz R, Nolen B, Adams JA, Ghosh G. PMID: 17239901.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    53. Transcriptional regulation via the NF-kappaB signaling module. Oncogene. 2006 Oct 30; 25(51):6706-16. Hoffmann A, Natoli G, Ghosh G. PMID: 17072323.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    54. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34. Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. PMID: 16756995.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    55. The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner. EMBO J. 2006 May 03; 25(9):1945-56. Moorthy AK, Savinova OV, Ho JQ, Wang VY, Vu D, Ghosh G. PMID: 16619030.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    56. Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods Enzymol. 2006; 407:527-34. Huxford T, Ghosh G. PMID: 16757350.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    57. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell. 2006 Feb; 17(2):876-85. Ding JH, Zhong XY, Hagopian JC, Cruz MM, Ghosh G, Feramisco J, Adams JA, Fu XD. PMID: 16319169.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    58. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Nov; 4(11):1892-901. Kennedy EJ, Pillus L, Ghosh G. PMID: 16278456.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    59. Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem. 2005 Dec 16; 280(50):41761-8. Velazquez-Dones A, Hagopian JC, Ma CT, Zhong XY, Zhou H, Ghosh G, Fu XD, Adams JA. PMID: 16223727.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    60. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell. 2005 Oct 07; 20(1):77-89. Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol BE, Adams JA, Fu XD, Ghosh G. PMID: 16209947.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    61. PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell. 2005 Sep 23; 122(6):823-5. Taylor SS, Haste NM, Ghosh G. PMID: 16179248.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    62. NF-kappaB RelB forms an intertwined homodimer. Structure. 2005 Sep; 13(9):1365-73. Huang DB, Vu D, Ghosh G. PMID: 16154093.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    63. Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB. J Mol Biol. 2005 Feb 11; 346(1):147-60. Huang DB, Phelps CB, Fusco AJ, Ghosh G. PMID: 15663934.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    64. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 2004 Oct 27; 23(21):4202-10. Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. PMID: 15470505.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    65. Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell. 2004 Sep 10; 15(5):661-75. Nolen B, Taylor S, Ghosh G. PMID: 15350212.
      View in: PubMed   Mentions: 383     Fields:    Translation:HumansAnimalsCells
    66. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 2004 Jul; 13(7):1767-77. Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. PMID: 15215520.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    67. Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. J Biol Chem. 2004 Jul 16; 279(29):30182-8. Aubol BE, Ungs L, Lukasiewicz R, Ghosh G, Adams JA. PMID: 15145958.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    68. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Mol Cell Biol. 2004 Apr; 24(7):3048-56. Chen Y, Vallee S, Wu J, Vu D, Sondek J, Ghosh G. PMID: 15024091.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    69. Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer. Curr Opin Struct Biol. 2004 Feb; 14(1):21-7. Ghosh G, Huang DB, Huxford T. PMID: 15102445.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    70. Novel destabilization of nucleotide binding by the gamma phosphate of ATP in the yeast SR protein kinase Sky1p. Biochemistry. 2003 Nov 11; 42(44):12813-20. Aubol BE, Nolen B, Shaffer J, Ghosh G, Adams JA. PMID: 14596595.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    71. Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12601-6. Aubol BE, Chakrabarti S, Ngo J, Shaffer J, Nolen B, Fu XD, Ghosh G, Adams JA. PMID: 14555757.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    72. Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography. Biochemistry. 2003 Aug 19; 42(32):9575-85. Nolen B, Ngo J, Chakrabarti S, Vu D, Adams JA, Ghosh G. PMID: 12911299.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    73. Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9268-73. Huang DB, Vu D, Cassiday LA, Zimmerman JM, Maher LJ, Ghosh G. PMID: 12886018.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    74. X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J Biol Chem. 2003 Jun 20; 278(25):23094-100. Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. PMID: 12686541.
      View in: PubMed   Mentions: 40     Fields:    Translation:Cells
    75. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. J Biol Chem. 2003 Jun 20; 278(25):23101-6. Chen Y, Wu J, Ghosh G. PMID: 12672800.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    76. Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. J Mol Biol. 2002 Dec 06; 324(4):587-97. Huxford T, Mishler D, Phelps CB, Huang DB, Sengchanthalangsy LL, Reeves R, Hughes CA, Komives EA, Ghosh G. PMID: 12460563.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    77. p105.Ikappa Bgamma and prototypical Ikappa Bs use a similar mechanism to bind but a different mechanism to regulate the subcellular localization of NF-kappa B. J Biol Chem. 2003 Jan 03; 278(1):556-66. Moorthy AK, Ghosh G. PMID: 12399470.
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