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Gourisankar Ghosh

Title(s)Professor, Chemistry and Biochemistry
SchoolAcademic Aff
Address9500 Gilman Drive #0375
La Jolla CA 92093
Phone858-822-0469
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    Collapse Research 
    Collapse Research Activities and Funding
    ASF/SF2: Phosphorylation and RNA Binding
    NIH/NIGMS R01GM084277Aug 10, 2009 - Jul 31, 2013
    Role: Principal Investigator
    IKK:Biophysical basis of dynamic regulation
    NIH/NCI R01CA141722Jul 1, 2009 - May 31, 2014
    Role: Principal Investigator
    Investigation of gene regulation by NF-kappaB transcription factors
    NIH/NIGMS R01GM085490Jul 1, 2009 - Oct 30, 2013
    Role: Principal Investigator
    IkB/NF-kB Recognition in Silico, In Vitro and In Vivo
    NIH/NIGMS P01GM071862Apr 7, 2006 - Mar 31, 2012
    Role: Co-Investigator
    NF-kB regulation by p105 and p100
    NIH/NIAID R01AI064326Feb 15, 2005 - Jan 31, 2011
    Role: Principal Investigator
    MECHANISM OF TRANSCRIPTIONAL INHIBITION BY IKB PROTEINS
    NIH/NCI R01CA078749Apr 1, 1999 - Mar 31, 2003
    Role: Principal Investigator
    Structure/Function Studies of Nuclear FActor KB
    NIH/NCI R01CA071871Sep 5, 1996 - Oct 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structural disruption of exonic stem-loops immediately upstream of the intron regulates mammalian splicing. Nucleic Acids Res. 2020 Jun 19; 48(11):6294-6309. Saha K, England W, Fernandez MM, Biswas T, Spitale RC, Ghosh G. PMID: 32402057.
      View in: PubMed   Mentions:    Fields:    
    2. Dissecting the Regulatory Strategies of NF-?B RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics. Cell Rep. 2020 Feb 25; 30(8):2758-2775.e6. Ngo KA, Kishimoto K, Davis-Turak J, Pimplaskar A, Cheng Z, Spreafico R, Chen EY, Tam A, Ghosh G, Mitchell S, Hoffmann A. PMID: 32101750.
      View in: PubMed   Mentions:    Fields:    
    3. Genome reading by the NF-?B transcription factors. Nucleic Acids Res. 2019 11 04; 47(19):9967-9989. Mulero MC, Wang VY, Huxford T, Ghosh G. PMID: 31501881.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. An NF?B Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NF?B via Distinct Mechanisms. Front Immunol. 2019; 10:1425. Mitchell S, Mercado EL, Adelaja A, Ho JQ, Cheng QJ, Ghosh G, Hoffmann A. PMID: 31293585.
      View in: PubMed   Mentions:    Fields:    
    5. NF-?B, I?B, and IKK: Integral Components of Immune System Signaling. Adv Exp Med Biol. 2019; 1172:207-226. Mulero MC, Huxford T, Ghosh G. PMID: 31628658.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. A Guide to Production, Crystallization, and Structure Determination of Human IKK1/a. J Vis Exp. 2018 11 02; (141). Polley S, Huang DB, Biswas T, Ghosh G. PMID: 30451218.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor ?B RelA Subunit. Biochemistry. 2018 05 22; 57(20):2943-2957. Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang DB, Wang VY, Amaro RE, Huxford T, Ghosh G. PMID: 29708732.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor ?B are not correlated. J Biol Chem. 2017 11 17; 292(46):18821-18830. Mulero MC, Huang DB, Nguyen HT, Wang VY, Li Y, Biswas T, Ghosh G. PMID: 28935669.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity. Mol Cell. 2017 Aug 03; 67(3):484-497.e5. Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G. PMID: 28689659.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. Structural Basis for the Activation of IKK1/a. Cell Rep. 2016 11 15; 17(8):1907-1914. Polley S, Passos DO, Huang DB, Mulero MC, Mazumder A, Biswas T, Verma IM, Lyumkis D, Ghosh G. PMID: 27851956.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    11. The NF-?B subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100. Sci Signal. 2016 09 27; 9(447):ra96. Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. PMID: 27678221.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. To Swap or Not To Swap. Structure. 2016 09 06; 24(9):1436-8. Ghosh G, Biswas T. PMID: 27602989.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity. Mol Cell. 2016 08 18; 63(4):544-546. Ghosh G, Sen M. PMID: 27540854.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. I?Bß enhances the generation of the low-affinity NF?B/RelA homodimer. Nat Commun. 2015 May 07; 6:7068. Tsui R, Kearns JD, Lynch C, Vu D, Ngo KA, Basak S, Ghosh G, Hoffmann A. PMID: 25946967.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. p100/I?Bd sequesters and inhibits NF-?B through kappaBsome formation. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15946-51. Tao Z, Fusco A, Huang DB, Gupta K, Young Kim D, Ware CF, Van Duyne GD, Ghosh G. PMID: 25349408.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    16. N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J. 2014 Aug 15; 462(1):143-52. Aubol BE, Plocinik RM, Keshwani MM, McGlone ML, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 24869919.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    17. Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. 2014 Apr 01; 53(12):2064-73. Hauenstein AV, Rogers WE, Shaul JD, Huang DB, Ghosh G, Huxford T. PMID: 24611898.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-?B-driven transcription. PLoS Biol. 2013 Sep; 11(9):e1001647. Mukherjee SP, Behar M, Birnbaum HA, Hoffmann A, Wright PE, Ghosh G. PMID: 24019758.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    19. PRMT5 dimethylates R30 of the p65 subunit to activate NF-?B. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13516-21. Wei H, Wang B, Miyagi M, She Y, Gopalan B, Huang DB, Ghosh G, Stark GR, Lu T. PMID: 23904475.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    20. Role of lysine methylation of NF-?B in differential gene regulation. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13510-5. Lu T, Yang M, Huang DB, Wei H, Ozer GH, Ghosh G, Stark GR. PMID: 23904479.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    21. A structural basis for I?B kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 2013; 11(6):e1001581. Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schröfelbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. PMID: 23776406.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    22. A structural basis for selective dimerization by NF-?B RelB. J Mol Biol. 2013 Jun 12; 425(11):1934-1945. Vu D, Huang DB, Vemu A, Ghosh G. PMID: 23485337.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. The transcriptional specificity of NF-?B dimers is coded within the ?B DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. PMID: 23063365.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    24. Understanding NIK regulation from its structure. Structure. 2012 Oct 10; 20(10):1615-7. Tao Z, Ghosh G. PMID: 23063006.
      View in: PubMed   Mentions: 1     Fields:    
    25. NEMO ensures signaling specificity of the pleiotropic IKKß by directing its kinase activity toward I?Ba. Mol Cell. 2012 Jul 13; 47(1):111-21. Schröfelbauer B, Polley S, Behar M, Ghosh G, Hoffmann A. PMID: 22633953.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    26. NF-?B regulation: lessons from structures. Immunol Rev. 2012 Mar; 246(1):36-58. Ghosh G, Wang VY, Huang DB, Fusco A. PMID: 22435546.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    27. The SRSF1 linker induces semi-conservative ESE binding by cooperating with the RRMs. Nucleic Acids Res. 2011 Nov; 39(21):9413-21. Cho S, Hoang A, Chakrabarti S, Huynh N, Huang DB, Ghosh G. PMID: 21852328.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    28. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8233-8. Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. PMID: 21536904.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    29. Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase. J Cell Biol. 2011 Apr 04; 193(1):41-50. Chawla A, Chakrabarti S, Ghosh G, Niwa M. PMID: 21444691.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    30. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-?B p50. Sci Signal. 2011 Feb 22; 4(161):ra11. Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. PMID: 21343618.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    31. NF-?B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15; 6(2):e16815. Ho JQ, Asagiri M, Hoffmann A, Ghosh G. PMID: 21347231.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J. 2011 Feb; 278(4):587-97. Ghosh G, Adams JA. PMID: 21205204.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    33. Understanding the logic of I?B:NF-?B regulation in structural terms. Curr Top Microbiol Immunol. 2011; 349:1-24. Huxford T, Hoffmann A, Ghosh G. PMID: 20845107.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    34. Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol. 2010 Oct 29; 403(3):386-404. Ma CT, Ghosh G, Fu XD, Adams JA. PMID: 20826166.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    35. Flexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal. J Biol Chem. 2010 Oct 22; 285(43):32927-36. Mathes E, Wang L, Komives E, Ghosh G. PMID: 20682784.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    36. Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1. Biochemistry. 2009 Dec 08; 48(48):11432-40. Huynh N, Ma CT, Giang N, Hagopian J, Ngo J, Adams J, Ghosh G. PMID: 19886675.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    37. Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19328-33. Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G, Komives EA. PMID: 19887633.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    38. A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol. 2009 Sep; 1(3):a000075. Huxford T, Ghosh G. PMID: 20066103.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    39. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell. 2009 Jun 12; 34(5):591-602. Savinova OV, Hoffmann A, Ghosh G. PMID: 19524538.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    40. Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9619-24. Shih VF, Kearns JD, Basak S, Savinova OV, Ghosh G, Hoffmann A. PMID: 19487661.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    41. Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2009 Jul 24; 390(4):618-34. Ma CT, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 19477182.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    42. Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure. 2009 Mar 11; 17(3):352-62. Bullock AN, Das S, Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Guo K, Papagrigoriou E, Amos AL, Cho S, Turk BE, Ghosh G, Knapp S. PMID: 19278650.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    43. Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One. 2009; 4(3):e4746. Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. PMID: 19270744.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    44. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009 Feb 15; 23(4):482-95. Zhong XY, Ding JH, Adams JA, Ghosh G, Fu XD. PMID: 19240134.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    45. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem. 2009 Mar 06; 284(10):6241-8. Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. PMID: 19122195.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    46. NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes. EMBO Rep. 2009 Feb; 10(2):152-9. Fusco AJ, Huang DB, Miller D, Wang VY, Vu D, Ghosh G. PMID: 19098713.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    47. Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts. J Immunol. 2008 Oct 01; 181(7):4441-5. Sen M, Ghosh G. PMID: 18802045.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    48. The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. Protein Sci. 2008 Dec; 17(12):2051-8. Bergqvist S, Ghosh G, Komives EA. PMID: 18824506.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    49. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2008 Oct 17; 382(4):894-909. Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings PA, Fu XD, Adams JA. PMID: 18687337.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    50. NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J. 2008 May 07; 27(9):1357-67. Mathes E, O'Dea EL, Hoffmann A, Ghosh G. PMID: 18401342.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    51. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell. 2008 Mar 14; 29(5):563-76. Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G. PMID: 18342604.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    52. Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J Mol Biol. 2008 Jun 27; 380(1):67-82. Truhlar SM, Mathes E, Cervantes CF, Ghosh G, Komives EA. PMID: 18511071.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    53. Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem. 2008 May 02; 283(18):12324-32. Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G. PMID: 18321863.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    54. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. J Biol Chem. 2008 Jan 11; 283(2):1084-93. Kennedy EJ, Ghosh G, Pillus L. PMID: 17971450.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    55. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 2007 Oct 30; 46(43):12482-90. Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. PMID: 17924664.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    56. Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. PLoS One. 2007 Sep 05; 2(9):e854. Shaw SD, Chakrabarti S, Ghosh G, Krainer AR. PMID: 17786225.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    57. X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. J Mol Biol. 2007 Oct 26; 373(3):723-34. Moorthy AK, Huang DB, Wang VY, Vu D, Ghosh G. PMID: 17869269.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    58. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. J Mol Biol. 2008 Feb 08; 376(1):55-68. Ma CT, Velazquez-Dones A, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 18155240.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    59. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007 Aug 10; 282(32):23036-43. Lukasiewicz R, Velazquez-Dones A, Huynh N, Hagopian J, Fu XD, Adams J, Ghosh G. PMID: 17517895.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    60. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 2007 Jan 26; 128(2):369-81. Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. PMID: 17254973.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    61. SR protein kinase 1 is resilient to inactivation. Structure. 2007 Jan; 15(1):123-33. Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G. PMID: 17223538.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    62. The RGG domain of Npl3p recruits Sky1p through docking interactions. J Mol Biol. 2007 Mar 16; 367(1):249-61. Lukasiewicz R, Nolen B, Adams JA, Ghosh G. PMID: 17239901.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    63. Transcriptional regulation via the NF-kappaB signaling module. Oncogene. 2006 Oct 30; 25(51):6706-16. Hoffmann A, Natoli G, Ghosh G. PMID: 17072323.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimalsCells
    64. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34. Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. PMID: 16756995.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    65. The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner. EMBO J. 2006 May 03; 25(9):1945-56. Moorthy AK, Savinova OV, Ho JQ, Wang VY, Vu D, Ghosh G. PMID: 16619030.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    66. Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods Enzymol. 2006; 407:527-34. Huxford T, Ghosh G. PMID: 16757350.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    67. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell. 2006 Feb; 17(2):876-85. Ding JH, Zhong XY, Hagopian JC, Cruz MM, Ghosh G, Feramisco J, Adams JA, Fu XD. PMID: 16319169.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    68. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Nov; 4(11):1892-901. Kennedy EJ, Pillus L, Ghosh G. PMID: 16278456.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    69. Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem. 2005 Dec 16; 280(50):41761-8. Velazquez-Dones A, Hagopian JC, Ma CT, Zhong XY, Zhou H, Ghosh G, Fu XD, Adams JA. PMID: 16223727.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    70. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell. 2005 Oct 07; 20(1):77-89. Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol BE, Adams JA, Fu XD, Ghosh G. PMID: 16209947.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    71. PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell. 2005 Sep 23; 122(6):823-5. Taylor SS, Haste NM, Ghosh G. PMID: 16179248.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    72. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 2005 Sep 15; 19(18):2138-51. Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. PMID: 16166378.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    73. NF-kappaB RelB forms an intertwined homodimer. Structure. 2005 Sep; 13(9):1365-73. Huang DB, Vu D, Ghosh G. PMID: 16154093.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    74. Enhanced intracellular mobility and nuclear accumulation of DNA plasmids associated with a karyophilic protein. Hum Gene Ther. 2005 Feb; 16(2):200-8. Mesika A, Kiss V, Brumfeld V, Ghosh G, Reich Z. PMID: 15761260.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    75. Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB. J Mol Biol. 2005 Feb 11; 346(1):147-60. Huang DB, Phelps CB, Fusco AJ, Ghosh G. PMID: 15663934.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    76. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 2004 Oct 27; 23(21):4202-10. Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. PMID: 15470505.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    77. Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell. 2004 Sep 10; 15(5):661-75. Nolen B, Taylor S, Ghosh G. PMID: 15350212.
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