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Dorothy Sears

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0673
La Jolla CA 92093
Phone858-534-8898
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    Collapse Research 
    Collapse Research Activities and Funding
    Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortality
    NIH/NIA P01AG052352Jul 1, 2017 - May 31, 2022
    Role: Co-Investigator
    Time-Restricted Feeding and Breast Cancer
    NIH/NCI R01CA196853Apr 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    (PQA4) GPS exposure to environments & relations with biomarkers of cancer risk
    NIH R01CA179977Sep 1, 2013 - Aug 31, 2017
    Role: Co-Investigator
    Energetics &Breast Cancer: Obesity, Inflammation, Insulin Resistance &Risk
    NIH/NCI U54CA155435Jul 7, 2011 - May 31, 2016
    Role: Co-Investigator
    IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    NIH/NIDDK K01DK062025Sep 15, 2002 - Jun 30, 2006
    Role: Principal Investigator
    NOVEL INSULIN SIGNAL TRANSDUCTION PROTEINS
    NIH/NIDDK F32DK009595Jul 5, 1997
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vella CA, Michos ED, Sears DD, Cushman M, Van Hollebeke RB, Wiest MM, Allison MA. Associations of Sedentary Behavior and Abdominal Muscle Density: The Multi-Ethnic Study of Atherosclerosis. J Phys Act Health. 2018 Oct 09; 1-7. PMID: 30301405.
      View in: PubMed
    2. Xu S, Thompson W, Kerr J, Godbole S, Sears DD, Patterson R, Natarajan L. Modeling interrelationships between health behaviors in overweight breast cancer survivors: Applying Bayesian networks. PLoS One. 2018; 13(9):e0202923. PMID: 30180192.
      View in: PubMed
    3. Patterson RE, Marinac CR, Sears DD, Kerr J, Hartman SJ, Cadmus-Bertram L, Villaseñor A, Flatt SW, Godbole S, Li H, Laughlin GA, Oratowski-Coleman J, Parker BA, Natarajan L. The Effects of Metformin and Weight Loss on Biomarkers Associated With Breast Cancer Outcomes. J Natl Cancer Inst. 2018 May 18. PMID: 29788487.
      View in: PubMed
    4. Schneider DA, Choi SH, Agatisa-Boyle C, Zhu L, Kim J, Pattison J, Sears DD, Gordts PLSM, Fang L, Miller YI. AIBP protects against metabolic abnormalities and atherosclerosis. J Lipid Res. 2018 May; 59(5):854-863. PMID: 29559522.
      View in: PubMed
    5. Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears DD. Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544. PMID: 29190761.
      View in: PubMed
    6. Hartman SJ, Nelson SH, Myers E, Natarajan L, Sears DD, Palmer BW, Weiner LS, Parker BA, Patterson RE. Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer. 2018 Jan 01; 124(1):192-202. PMID: 28926676.
      View in: PubMed
    7. Hartman SJ, Marinac CR, Cadmus-Bertram L, Kerr J, Natarajan L, Godbole S, Patterson RE, Morey B, Sears DD. Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors. J Phys Act Health. 2018 Jan 01; 15(1):1-6. PMID: 28682735.
      View in: PubMed
    8. Patterson RE, Sears DD. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr. 2017 08 21; 37:371-393. PMID: 28715993.
      View in: PubMed
    9. Jankowska MM, Natarajan L, Godbole S, Meseck K, Sears DD, Patterson RE, Kerr J. Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors. Cancer Epidemiol Biomarkers Prev. 2017 Jul; 26(7):1078-1084. PMID: 28258052.
      View in: PubMed
    10. Mongraw-Chaffin M, LaCroix AZ, Sears DD, Garcia L, Phillips LS, Salmoirago-Blotcher E, Zaslavsky O, Anderson CA. A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality: The Women's Health Initiative. Metabolism. 2017 05; 70:116-124. PMID: 28403935.
      View in: PubMed
    11. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. PMID: 27814523.
      View in: PubMed
    12. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. PMID: 27832862.
      View in: PubMed
    13. Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, Flatt SW, Sears DD, Patterson RE. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncol. 2016 Aug 01; 2(8):1049-55. PMID: 27032109; PMCID: PMC4982776 [Available on 08/01/17].
    14. Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253. PMID: 27394413.
      View in: PubMed
    15. Hartman SJ, Natarajan L, Palmer BW, Parker B, Patterson RE, Sears DD. Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion. Contemp Clin Trials. 2015 Nov; 45(Pt B):371-376. PMID: 26427563; PMCID: PMC4674350 [Available on 11/01/16].
    16. Marinac CR, Sears DD, Natarajan L, Gallo LC, Breen CI, Patterson RE. Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk. PLoS One. 2015; 10(8):e0136240. PMID: 26305095; PMCID: PMC4549297.
    17. Bellettiere J, Carlson JA, Rosenberg D, Singhania A, Natarajan L, Berardi V, LaCroix AZ, Sears DD, Moran K, Crist K, Kerr J. Gender and Age Differences in Hourly and Daily Patterns of Sedentary Time in Older Adults Living in Retirement Communities. PLoS One. 2015; 10(8):e0136161. PMID: 26296095; PMCID: PMC4546658.
    18. Marinac CR, Natarajan L, Sears DD, Gallo LC, Hartman SJ, Arredondo E, Patterson RE. Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009-2010). Cancer Epidemiol Biomarkers Prev. 2015 May; 24(5):783-9. PMID: 25896523; PMCID: PMC4417458.
    19. Patterson RE, Laughlin GA, LaCroix AZ, Hartman SJ, Natarajan L, Senger CM, Martínez ME, Villaseñor A, Sears DD, Marinac CR, Gallo LC. Intermittent Fasting and Human Metabolic Health. J Acad Nutr Diet. 2015 Aug; 115(8):1203-12. PMID: 25857868; PMCID: PMC4516560.
    20. Dunn TN, Akiyama T, Lee HW, Kim JB, Knotts TA, Smith SR, Sears DD, Carstens E, Adams SH. Evaluation of the synuclein-? (SNCG) gene as a PPAR? target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue. PLoS One. 2015; 10(3):e0115830. PMID: 25756178; PMCID: PMC4355072.
    21. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears DD. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. PMID: 25251155; PMCID: PMC4175074.
    22. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
    23. Ham M, Lee JW, Choi AH, Jang H, Choi G, Park J, Kozuka C, Sears DD, Masuzaki H, Kim JB. Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. Mol Cell Biol. 2013 Jun; 33(12):2425-35. PMID: 23572562; PMCID: PMC3700093.
    24. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control. 2013 Apr; 24(4):695-704. PMID: 23378138; PMCID: PMC3602225.
    25. Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky JM, Sears DD, Kaplan LM, Kemp DM. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013 Mar; 62(3):855-63. PMID: 23223024; PMCID: PMC3581230.
    26. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. SirT1 regulates adipose tissue inflammation. Diabetes. 2011 Dec; 60(12):3235-45. PMID: 22110092; PMCID: PMC3219953.
    27. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. Adipocyte NCoR knockout decreases PPAR? phosphorylation and enhances PPAR? activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4):815-26. PMID: 22078880; PMCID: PMC3783197.
    28. Osborn O, Sears DD, Olefsky JM. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 01; 12(6):553-4. PMID: 21109185.
      View in: PubMed
    29. Chapman J, Miles PD, Ofrecio JM, Neels JG, Yu JG, Resnik JL, Wilkes J, Talukdar S, Thapar D, Johnson K, Sears DD. Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice. PLoS One. 2010 Nov 12; 5(11):e13959. PMID: 21103061; PMCID: PMC2980483.
    30. Hsiao G, Chapman J, Ofrecio JM, Wilkes J, Resnik JL, Thapar D, Subramaniam S, Sears DD. Multi-tissue, selective PPAR? modulation of insulin sensitivity and metabolic pathways in obese rats. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E164-74. PMID: 20959535; PMCID: PMC3023199.
    31. Kim JJ, Sears DD. TLR4 and Insulin Resistance. Gastroenterol Res Pract. 2010; 2010. PMID: 20814545; PMCID: PMC2931384.
    32. Li P, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010 May 14; 285(20):15333-45. PMID: 20308074; PMCID: PMC2865288.
    33. Knotts TA, Lee HW, Kim JB, Oort PJ, McPherson R, Dent R, Tachibana K, Doi T, Yu S, Reddy JK, Uno K, Katagiri H, Pasarica M, Smith SR, Sears DD, Grino M, Adams SH. Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans. PPAR Res. 2009; 2009:867678. PMID: 20204174; PMCID: PMC2830574.
    34. Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky JM, Evans RM. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22504-9. PMID: 20018750.
      View in: PubMed
    35. Sears DD, Hsiao G, Hsiao A, Yu JG, Courtney CH, Ofrecio JM, Chapman J, Subramaniam S. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18745-50. PMID: 19841271.
      View in: PubMed
    36. Sears DD, Miles PD, Chapman J, Ofrecio JM, Almazan F, Thapar D, Miller YI. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One. 2009 Sep 29; 4(9):e7250. PMID: 19787041; PMCID: PMC2746280.
    37. Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears DD, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul; 23(7):975-88. PMID: 19389808.
      View in: PubMed
    38. Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky JM. FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem. 2009 May 01; 284(18):12188-97. PMID: 19246449; PMCID: PMC2673287.
    39. Sears DD, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky JM. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):515-21. PMID: 17963725; PMCID: PMC2585742.
    40. Worrall DS, Olefsky JM. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. PMID: 11818508.
      View in: PubMed