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Dorothy Sears

Title(s)Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0673
La Jolla CA 92093
Phone858-534-8898
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    Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortality
    NIH/NIA P01AG052352Jul 1, 2017 - May 31, 2022
    Role: Co-Investigator
    Time-Restricted Feeding and Breast Cancer
    NIH R01CA196853Apr 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    (PQA4) GPS exposure to environments & relations with biomarkers of cancer risk
    NIH/NCI R01CA179977Sep 1, 2013 - Aug 31, 2017
    Role: Co-Investigator
    Energetics & Breast Cancer: Obesity, Inflammation, Insulin Resistance & Risk
    NIH U54CA155435Jul 7, 2011 - May 31, 2017
    Role: Co-Investigator
    IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    NIH K01DK062025Sep 15, 2002 - Jun 30, 2006
    Role: Principal Investigator
    NOVEL INSULIN SIGNAL TRANSDUCTION PROTEINS
    NIH F32DK009595Jul 5, 1997
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women. Sci Rep. 2021 Jun 03; 11(1):11766. Chang YJ, Tuz-Zahra F, Godbole S, Avitia Y, Bellettiere J, Rock CL, Jankowska MM, Allison MA, Dunstan DW, Rana B, Natarajan L, Sears DD. PMID: 34083573.
      View in: PubMed   Mentions:    Fields:    
    2. Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial. JMIR Res Protoc. 2021 May 13; 10(5):e28684. Hartman SJ, Dillon LW, LaCroix AZ, Natarajan L, Sears DD, Owen N, Dunstan DW, Sallis JF, Schenk S, Allison M, Takemoto M, Herweck AM, Nguyen B, Rosenberg DE. PMID: 33983131.
      View in: PubMed   Mentions:
    3. Device-Measured and Self-Reported Active Travel Associations with Cardiovascular Disease Risk Factors in an Ethnically Diverse Sample of Adults. Int J Environ Res Public Health. 2021 Apr 08; 18(8). Crist K, Benmarhnia T, Zamora S, Yang JA, Sears DD, Natarajan L, Dillon L, Sallis JF, Jankowska MM. PMID: 33917841.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Recent advances and health implications of dietary fasting regimens on the gut microbiome. Am J Physiol Gastrointest Liver Physiol. 2021 Mar 17. Mohr AE, Gumpricht E, Sears DD, Sweazea KL. PMID: 33729005.
      View in: PubMed   Mentions:    Fields:    
    5. Go Red for Women Strategically Focused Research Network: Summary of Findings and Network Outcomes. J Am Heart Assoc. 2021 Feb 23; e019519. St-Onge MP, Aggarwal B, Allison MA, Berger JS, Castañeda SF, Catov J, Hochman JS, Hubel CA, Jelic S, Kass DA, Makarem N, Michos ED, Mosca L, Ouyang P, Park C, Post WS, Powers RW, Reynolds HR, Sears DD, Shah SJ, Sharma K, Spruill T, Talavera GA, Vaidya D. PMID: 33619972.
      View in: PubMed   Mentions:    Fields:    
    6. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Nat Commun. 2021 01 25; 12(1):565. Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, Mandt T, Newton IG, Kaur M, Sears DD, Webster NJG. PMID: 33495474.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. A randomized trial of physical activity for cognitive functioning in breast cancer survivors: Rationale and study design of I can! improving cognition after cancer. Contemp Clin Trials. 2021 Jan 24; 106289. Hartman SJ, Weiner LS, Natarajan L, Sears DD, Palmer BW, Parker B, Ahles T, Irwin ML, Au K. PMID: 33503496.
      View in: PubMed   Mentions:    Fields:    
    8. Habitual Nightly Fasting Duration, Eating Timing, and Eating Frequency are Associated with Cardiometabolic Risk in Women. Nutrients. 2020 Oct 04; 12(10). Makarem N, Sears DD, St-Onge MP, Zuraikat FM, Gallo LC, Talavera GA, Castaneda SF, Lai Y, Mi J, Aggarwal B. PMID: 33020429.
      View in: PubMed   Mentions:    Fields:    
    9. Diurnal patterns of sedentary behavior and changes in physical function over time among older women: a prospective cohort study. Int J Behav Nutr Phys Act. 2020 07 09; 17(1):88. Reuter C, Bellettiere J, Liles S, Di C, Sears DD, LaMonte MJ, Stefanick ML, LaCroix AZ, Natarajan L. PMID: 32646435.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Sugar-Sweetened Beverage Intake and Cardiovascular Disease Risk in the California Teachers Study. J Am Heart Assoc. 2020 05 18; 9(10):e014883. Pacheco LS, Lacey JV, Martinez ME, Lemus H, Araneta MRG, Sears DD, Talavera GA, Anderson CAM. PMID: 32397792.
      View in: PubMed   Mentions: 1     Fields:    
    11. Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers. J Am Heart Assoc. 2020 02 18; 9(4):e013403. Chang YJ, Bellettiere J, Godbole S, Keshavarz S, Maestas JP, Unkart JT, Ervin D, Allison MA, Rock CL, Patterson RE, Jankowska MM, Kerr J, Natarajan L, Sears DD. PMID: 32063113.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Using Isotemporal Analyses to Examine the Relationships Between Daytime Activities and Cancer Recurrence Biomarkers in Breast Cancer Survivors. J Phys Act Health. 2020 02 01; 17(2):217-224. Full KM, Johnson E, Takemoto M, Hartman SJ, Kerr J, Natarajan L, Patterson RE, Sears DD. PMID: 31923899.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Mediators of a Physical Activity Intervention on Cognition in Breast Cancer Survivors: Evidence From a Randomized Controlled Trial. JMIR Cancer. 2019 Oct 11; 5(2):e13150. Hartman SJ, Weiner LS, Nelson SH, Natarajan L, Patterson RE, Palmer BW, Parker BA, Sears DD. PMID: 31605514.
      View in: PubMed   Mentions:
    14. Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study. PLoS One. 2019; 14(10):e0223638. Pacheco LS, Anderson CAM, Lacey JV, Giovannucci EL, Lemus H, Araneta MRG, Sears DD, Talavera GA, Martinez ME. PMID: 31596902.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. A novel biomarker of cardiometabolic pathology in schizophrenia? J Psychiatr Res. 2019 10; 117:31-37. Lee EE, Sears DD, Liu J, Jin H, Tu XM, Eyler LT, Jeste DV. PMID: 31276836.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention. J Cancer Surviv. 2019 06; 13(3):468-476. Weiner LS, Takemoto M, Godbole S, Nelson SH, Natarajan L, Sears DD, Hartman SJ. PMID: 31144265.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019 04 12; 364(6436). Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. PMID: 30975860.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    18. Association of Low Fasting Glucose and HbA1c With Cardiovascular Disease and Mortality: The MESA Study. J Endocr Soc. 2019 May 01; 3(5):892-901. Mongraw-Chaffin M, Bertoni AG, Golden SH, Mathioudakis N, Sears DD, Szklo M, Anderson CAM. PMID: 31020054.
      View in: PubMed   Mentions:
    19. Protocol for a cross sectional study of cancer risk, environmental exposures and lifestyle behaviors in a diverse community sample: the Community of Mine study. BMC Public Health. 2019 Feb 13; 19(1):186. Jankowska MM, Sears DD, Natarajan L, Martinez E, Anderson CAM, Sallis JF, Matthews SA, Crist K, Dillon L, Johnson E, Barrera-Ng A, Full K, Godbole S, Kerr J. PMID: 30760246.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    20. Arriba por la Vida Estudio (AVE): Study protocol for a standing intervention targeting postmenopausal Latinas. Contemp Clin Trials. 2019 04; 79:66-72. Takemoto M, Schechtman M, Villa N, Talavera G, Sears DD, Natarajan L, Owen N, Rosenberg DE, Dunstan D, Allison M, Kerr J. PMID: 30771560.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    21. The Effects of Metformin and Weight Loss on Biomarkers Associated With Breast Cancer Outcomes. J Natl Cancer Inst. 2018 11 01; 110(11):1239-1247. Patterson RE, Marinac CR, Sears DD, Kerr J, Hartman SJ, Cadmus-Bertram L, Villaseñor A, Flatt SW, Godbole S, Li H, Laughlin GA, Oratowski-Coleman J, Parker BA, Natarajan L. PMID: 29788487.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    22. Associations of Sedentary Behavior and Abdominal Muscle Density: The Multi-Ethnic Study of Atherosclerosis. J Phys Act Health. 2018 11 01; 15(11):827-833. Vella CA, Michos ED, Sears DD, Cushman M, Van Hollebeke RB, Wiest MM, Allison MA. PMID: 30301405.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Modeling interrelationships between health behaviors in overweight breast cancer survivors: Applying Bayesian networks. PLoS One. 2018; 13(9):e0202923. Xu S, Thompson W, Kerr J, Godbole S, Sears DD, Patterson R, Natarajan L. PMID: 30180192.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    24. AIBP protects against metabolic abnormalities and atherosclerosis. J Lipid Res. 2018 05; 59(5):854-863. Schneider DA, Choi SH, Agatisa-Boyle C, Zhu L, Kim J, Pattison J, Sears DD, Gordts PLSM, Fang L, Miller YI. PMID: 29559522.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    25. Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544. Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears DD. PMID: 29190761.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond). 2018 04; 42(4):728-736. Hernandez-Carretero A, Weber N, La Frano MR, Ying W, Lantero Rodriguez J, Sears DD, Wallenius V, Börgeson E, Newman JW, Osborn O. PMID: 29089614.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    27. Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer. 2018 Jan 01; 124(1):192-202. Hartman SJ, Nelson SH, Myers E, Natarajan L, Sears DD, Palmer BW, Weiner LS, Parker BA, Patterson RE. PMID: 28926676.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    28. Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors. J Phys Act Health. 2018 01 01; 15(1):1-6. Hartman SJ, Marinac CR, Cadmus-Bertram L, Kerr J, Natarajan L, Godbole S, Patterson RE, Morey B, Sears DD. PMID: 28682735.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr. 2017 08 21; 37:371-393. Patterson RE, Sears DD. PMID: 28715993.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    30. Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors. Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1078-1084. Jankowska MM, Natarajan L, Godbole S, Meseck K, Sears DD, Patterson RE, Kerr J. PMID: 28258052.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    31. A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality: The Women's Health Initiative. Metabolism. 2017 05; 70:116-124. Mongraw-Chaffin M, LaCroix AZ, Sears DD, Garcia L, Phillips LS, Salmoirago-Blotcher E, Zaslavsky O, Anderson CA. PMID: 28403935.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    32. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. PMID: 27814523.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    33. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. PMID: 27832862.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    34. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncol. 2016 Aug 01; 2(8):1049-55. Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, Flatt SW, Sears DD, Patterson RE. PMID: 27032109.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    35. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253. Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE. PMID: 27394413.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion. Contemp Clin Trials. 2015 Nov; 45(Pt B):371-376. Hartman SJ, Natarajan L, Palmer BW, Parker B, Patterson RE, Sears DD. PMID: 26427563.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    37. Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk. PLoS One. 2015; 10(8):e0136240. Marinac CR, Sears DD, Natarajan L, Gallo LC, Breen CI, Patterson RE. PMID: 26305095.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    38. Gender and Age Differences in Hourly and Daily Patterns of Sedentary Time in Older Adults Living in Retirement Communities. PLoS One. 2015; 10(8):e0136161. Bellettiere J, Carlson JA, Rosenberg D, Singhania A, Natarajan L, Berardi V, LaCroix AZ, Sears DD, Moran K, Crist K, Kerr J. PMID: 26296095.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    39. Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009-2010). Cancer Epidemiol Biomarkers Prev. 2015 May; 24(5):783-9. Marinac CR, Natarajan L, Sears DD, Gallo LC, Hartman SJ, Arredondo E, Patterson RE. PMID: 25896523.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    40. Intermittent Fasting and Human Metabolic Health. J Acad Nutr Diet. 2015 Aug; 115(8):1203-12. Patterson RE, Laughlin GA, LaCroix AZ, Hartman SJ, Natarajan L, Senger CM, Martínez ME, Villaseñor A, Sears DD, Marinac CR, Gallo LC. PMID: 25857868.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    41. Evaluation of the synuclein-? (SNCG) gene as a PPAR? target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue. PLoS One. 2015; 10(3):e0115830. Dunn TN, Akiyama T, Lee HW, Kim JB, Knotts TA, Smith SR, Sears DD, Carstens E, Adams SH. PMID: 25756178.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears DD. PMID: 25251155.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    43. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. PMID: 25220417.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    44. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    45. Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. Mol Cell Biol. 2013 Jun; 33(12):2425-35. Ham M, Lee JW, Choi AH, Jang H, Choi G, Park J, Kozuka C, Sears DD, Masuzaki H, Kim JB. PMID: 23572562.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    46. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control. 2013 Apr; 24(4):695-704. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. PMID: 23378138.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    47. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013 Mar; 62(3):855-63. Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky JM, Sears DD, Kaplan LM, Kemp DM. PMID: 23223024.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    48. SirT1 regulates adipose tissue inflammation. Diabetes. 2011 Dec; 60(12):3235-45. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. PMID: 22110092.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    49. Adipocyte NCoR knockout decreases PPAR? phosphorylation and enhances PPAR? activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4):815-26. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. PMID: 22078880.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    50. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 01; 12(6):553-4. Osborn O, Sears DD, Olefsky JM. PMID: 21109185.
      View in: PubMed   Mentions: 5     Fields:    
    51. Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice. PLoS One. 2010 Nov 12; 5(11):e13959. Chapman J, Miles PD, Ofrecio JM, Neels JG, Yu JG, Resnik JL, Wilkes J, Talukdar S, Thapar D, Johnson K, Sears DD. PMID: 21103061.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    52. Multi-tissue, selective PPAR? modulation of insulin sensitivity and metabolic pathways in obese rats. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E164-74. Hsiao G, Chapman J, Ofrecio JM, Wilkes J, Resnik JL, Thapar D, Subramaniam S, Sears DD. PMID: 20959535.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    53. TLR4 and Insulin Resistance. Gastroenterol Res Pract. 2010; 2010. Kim JJ, Sears DD. PMID: 20814545.
      View in: PubMed   Mentions:
    54. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010 May 14; 285(20):15333-15345. Li P, Lu M, Nguyen MTA, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM. PMID: 20308074.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    55. Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans. PPAR Res. 2009; 2009:867678. Knotts TA, Lee HW, Kim JB, Oort PJ, McPherson R, Dent R, Tachibana K, Doi T, Yu S, Reddy JK, Uno K, Katagiri H, Pasarica M, Smith SR, Sears DD, Grino M, Adams SH. PMID: 20204174.
      View in: PubMed   Mentions:
    56. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22504-9. Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky JM, Evans RM. PMID: 20018750.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    57. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18745-50. Sears DD, Hsiao G, Hsiao A, Yu JG, Courtney CH, Ofrecio JM, Chapman J, Subramaniam S. PMID: 19841271.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCellsCTClinical Trials
    58. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One. 2009 Sep 29; 4(9):e7250. Sears DD, Miles PD, Chapman J, Ofrecio JM, Almazan F, Thapar D, Miller YI. PMID: 19787041.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    59. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul; 23(7):975-88. Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears DD, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE. PMID: 19389808.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    60. FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem. 2009 May 01; 284(18):12188-97. Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky JM. PMID: 19246449.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    61. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):515-21. Sears DD, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky JM. PMID: 17963725.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    62. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. Worrall DS, Olefsky JM. PMID: 11818508.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    63. Increased instability of human CTG repeat tracts on yeast artificial chromosomes during gametogenesis. Mol Cell Biol. 1999 Jun; 19(6):4153-8. Cohen H, Sears DD, Zenvirth D, Hieter P, Simchen G. PMID: 10330155.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    64. The legacy of Allan Hills 84001 Meteorit Planet Sci. 1998 Jul; 33(4):545-6. Sears D, Scott E, Warren P. PMID: 11543068.
      View in: PubMed   Mentions:
    65. Cis-acting determinants affecting centromere function, sister-chromatid cohesion and reciprocal recombination during meiosis in Saccharomyces cerevisiae. Genetics. 1995 Mar; 139(3):1159-73. Sears DD, Hegemann JH, Shero JH, Hieter P. PMID: 7768430.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    66. An implanted recombination hot spot stimulates recombination and enhances sister chromatid cohesion of heterologous YACs during yeast meiosis. Genetics. 1994 Dec; 138(4):1055-65. Sears DD, Hieter P, Simchen G. PMID: 7896090.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    67. The cytologic diagnosis of malignant neoplasms in pleural and peritoneal effusions. Acta Cytol. 1987 Mar-Apr; 31(2):85-97. Sears D, Hajdu SI. PMID: 3469856.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
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