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Dorothy Sears

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0673
La Jolla CA 92093
Phone858-534-8898
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    Collapse Research 
    Collapse Research Activities and Funding
    Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortality
    NIH/NIA P01AG052352Jul 1, 2017 - May 31, 2022
    Role: Co-Investigator
    Time-Restricted Feeding and Breast Cancer
    NIH/NCI R01CA196853Apr 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    (PQA4) GPS exposure to environments & relations with biomarkers of cancer risk
    NIH R01CA179977Sep 1, 2013 - Aug 31, 2017
    Role: Co-Investigator
    Energetics &Breast Cancer: Obesity, Inflammation, Insulin Resistance &Risk
    NIH/NCI U54CA155435Jul 7, 2011 - May 31, 2016
    Role: Co-Investigator
    IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    NIH/NIDDK K01DK062025Sep 15, 2002 - Jun 30, 2006
    Role: Principal Investigator
    NOVEL INSULIN SIGNAL TRANSDUCTION PROTEINS
    NIH/NIDDK F32DK009595Jul 5, 1997
    Role: Principal Investigator

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    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Schneider DA, Choi SH, Agatisa-Boyle C, Zhu L, Kim J, Pattison J, Sears D, Gordts PLSM, Fang L, Miller YI. AIBP protects against metabolic abnormalities and atherosclerosis. J Lipid Res. 2018 May; 59(5):854-863. PMID: 29559522.
      View in: PubMed
    2. Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears D. Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544. PMID: 29190761.
      View in: PubMed
    3. Hartman SJ, Nelson SH, Myers E, Natarajan L, Sears D, Palmer BW, Weiner LS, Parker BA, Patterson RE. Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer. 2018 Jan 01; 124(1):192-202. PMID: 28926676.
      View in: PubMed
    4. Hartman SJ, Marinac CR, Cadmus-Bertram L, Kerr J, Natarajan L, Godbole S, Patterson RE, Morey B, Sears D. Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors. J Phys Act Health. 2018 Jan 01; 15(1):1-6. PMID: 28682735.
      View in: PubMed
    5. Patterson RE, Sears D. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr. 2017 08 21; 37:371-393. PMID: 28715993.
      View in: PubMed
    6. Jankowska MM, Natarajan L, Godbole S, Meseck K, Sears D, Patterson RE, Kerr J. Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors. Cancer Epidemiol Biomarkers Prev. 2017 Jul; 26(7):1078-1084. PMID: 28258052.
      View in: PubMed
    7. Mongraw-Chaffin M, LaCroix AZ, Sears D, Garcia L, Phillips LS, Salmoirago-Blotcher E, Zaslavsky O, Anderson CA. A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality: The Women's Health Initiative. Metabolism. 2017 05; 70:116-124. PMID: 28403935.
      View in: PubMed
    8. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. PMID: 27814523.
      View in: PubMed
    9. Chung H, Chou W, Sears D, Patterson RE, Webster NJ, Ellies LG. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. PMID: 27832862.
      View in: PubMed
    10. Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, Flatt SW, Sears D, Patterson RE. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncol. 2016 Aug 01; 2(8):1049-55. PMID: 27032109; PMCID: PMC4982776 [Available on 08/01/17].
      View in: PubMed, PubMed Central
    11. Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears D, Feldstein AE. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253. PMID: 27394413.
      View in: PubMed
    12. Hartman SJ, Natarajan L, Palmer BW, Parker B, Patterson RE, Sears D. Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion. Contemp Clin Trials. 2015 Nov; 45(Pt B):371-376. PMID: 26427563; PMCID: PMC4674350 [Available on 11/01/16].
      View in: PubMed, PubMed Central
    13. Marinac CR, Sears D, Natarajan L, Gallo LC, Breen CI, Patterson RE. Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk. PLoS One. 2015; 10(8):e0136240. PMID: 26305095; PMCID: PMC4549297.
      View in: PubMed, PubMed Central
    14. Bellettiere J, Carlson JA, Rosenberg D, Singhania A, Natarajan L, Berardi V, LaCroix AZ, Sears D, Moran K, Crist K, Kerr J. Gender and Age Differences in Hourly and Daily Patterns of Sedentary Time in Older Adults Living in Retirement Communities. PLoS One. 2015; 10(8):e0136161. PMID: 26296095; PMCID: PMC4546658.
      View in: PubMed, PubMed Central
    15. Marinac CR, Natarajan L, Sears D, Gallo LC, Hartman SJ, Arredondo E, Patterson RE. Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009-2010). Cancer Epidemiol Biomarkers Prev. 2015 May; 24(5):783-9. PMID: 25896523; PMCID: PMC4417458.
      View in: PubMed, PubMed Central
    16. Patterson RE, Laughlin GA, LaCroix AZ, Hartman SJ, Natarajan L, Senger CM, Martínez ME, Villaseñor A, Sears D, Marinac CR, Gallo LC. Intermittent Fasting and Human Metabolic Health. J Acad Nutr Diet. 2015 Aug; 115(8):1203-12. PMID: 25857868; PMCID: PMC4516560.
      View in: PubMed, PubMed Central
    17. Dunn TN, Akiyama T, Lee HW, Kim JB, Knotts TA, Smith SR, Sears D, Carstens E, Adams SH. Evaluation of the synuclein-? (SNCG) gene as a PPAR? target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue. PLoS One. 2015; 10(3):e0115830. PMID: 25756178; PMCID: PMC4355072.
      View in: PubMed, PubMed Central
    18. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears D. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. PMID: 25251155; PMCID: PMC4175074.
      View in: PubMed, PubMed Central
    19. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears D, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
      View in: PubMed, PubMed Central
    20. Ham M, Lee JW, Choi AH, Jang H, Choi G, Park J, Kozuka C, Sears D, Masuzaki H, Kim JB. Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. Mol Cell Biol. 2013 Jun; 33(12):2425-35. PMID: 23572562; PMCID: PMC3700093.
      View in: PubMed, PubMed Central
    21. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears D, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control. 2013 Apr; 24(4):695-704. PMID: 23378138; PMCID: PMC3602225.
      View in: PubMed, PubMed Central
    22. Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky JM, Sears D, Kaplan LM, Kemp DM. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013 Mar; 62(3):855-63. PMID: 23223024; PMCID: PMC3581230.
      View in: PubMed, PubMed Central
    23. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears D, Caprio S, Shulman GI. SirT1 regulates adipose tissue inflammation. Diabetes. 2011 Dec; 60(12):3235-45. PMID: 22110092; PMCID: PMC3219953.
      View in: PubMed, PubMed Central
    24. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears D, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. Adipocyte NCoR knockout decreases PPAR? phosphorylation and enhances PPAR? activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4):815-26. PMID: 22078880; PMCID: PMC3783197.
      View in: PubMed, PubMed Central
    25. Osborn O, Sears D, Olefsky JM. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 01; 12(6):553-4. PMID: 21109185.
      View in: PubMed
    26. Chapman J, Miles PD, Ofrecio JM, Neels JG, Yu JG, Resnik JL, Wilkes J, Talukdar S, Thapar D, Johnson K, Sears D. Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice. PLoS One. 2010 Nov 12; 5(11):e13959. PMID: 21103061; PMCID: PMC2980483.
      View in: PubMed, PubMed Central
    27. Hsiao G, Chapman J, Ofrecio JM, Wilkes J, Resnik JL, Thapar D, Subramaniam S, Sears D. Multi-tissue, selective PPAR? modulation of insulin sensitivity and metabolic pathways in obese rats. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E164-74. PMID: 20959535; PMCID: PMC3023199.
      View in: PubMed, PubMed Central
    28. Kim JJ, Sears D. TLR4 and Insulin Resistance. Gastroenterol Res Pract. 2010; 2010. PMID: 20814545; PMCID: PMC2931384.
      View in: PubMed, PubMed Central
    29. Li P, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears D, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010 May 14; 285(20):15333-45. PMID: 20308074; PMCID: PMC2865288.
      View in: PubMed, PubMed Central
    30. Knotts TA, Lee HW, Kim JB, Oort PJ, McPherson R, Dent R, Tachibana K, Doi T, Yu S, Reddy JK, Uno K, Katagiri H, Pasarica M, Smith SR, Sears D, Grino M, Adams SH. Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans. PPAR Res. 2009; 2009:867678. PMID: 20204174; PMCID: PMC2830574.
      View in: PubMed, PubMed Central
    31. Sugii S, Olson P, Sears D, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky JM, Evans RM. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22504-9. PMID: 20018750.
      View in: PubMed
    32. Sears D, Hsiao G, Hsiao A, Yu JG, Courtney CH, Ofrecio JM, Chapman J, Subramaniam S. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18745-50. PMID: 19841271.
      View in: PubMed
    33. Sears D, Miles PD, Chapman J, Ofrecio JM, Almazan F, Thapar D, Miller YI. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One. 2009 Sep 29; 4(9):e7250. PMID: 19787041; PMCID: PMC2746280.
      View in: PubMed, PubMed Central
    34. Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears D, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul; 23(7):975-88. PMID: 19389808.
      View in: PubMed
    35. Fan W, Imamura T, Sonoda N, Sears D, Patsouris D, Kim JJ, Olefsky JM. FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem. 2009 May 01; 284(18):12188-97. PMID: 19246449; PMCID: PMC2673287.
      View in: PubMed, PubMed Central
    36. Sears D, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky JM. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):515-21. PMID: 17963725; PMCID: PMC2585742.
      View in: PubMed, PubMed Central
    37. Worrall DS, Olefsky JM. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. PMID: 11818508.
      View in: PubMed
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