Dorothy Sears

Title(s)Adjunct Professor, Family Medicine and Public Health
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortality
    NIH/NIA P01AG052352Jul 1, 2017 - May 31, 2022
    Role: Co-Investigator
    Time-Restricted Feeding and Breast Cancer
    NIH R01CA196853Apr 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    (PQA4) GPS exposure to environments & relations with biomarkers of cancer risk
    NIH/NCI R01CA179977Sep 1, 2013 - Aug 31, 2017
    Role: Co-Investigator
    Energetics & Breast Cancer: Obesity, Inflammation, Insulin Resistance & Risk
    NIH U54CA155435Jul 7, 2011 - May 31, 2017
    Role: Co-Investigator
    IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    NIH K01DK062025Sep 15, 2002 - Jun 30, 2006
    Role: Principal Investigator
    NOVEL INSULIN SIGNAL TRANSDUCTION PROTEINS
    NIH F32DK009595Jul 5, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Design and Rationale of Prolonged Nightly Fasting for Multiple Myeloma Prevention (PROFAST): Protocol for a Randomized Controlled Pilot Trial. JMIR Res Protoc. 2024 Mar 11; 13:e51368. Lee DJ, O'Donnell EK, Raje N, Panaroni C, Redd R, Ligibel J, Sears DD, Nadeem O, Ghobrial IM, Marinac CR. PMID: 38466984.
      View in: PubMed   Mentions:
    2. Differences in metabolic biomarkers in people with schizophrenia who are of Mexican descent compared to non-Hispanic whites. Psychiatry Res. 2024 Apr; 334:115788. Kwak PP, Ibarra C, Hernandez A, Carrasco J, Sears DD, Jeste D, Marquine MJ, Lee EE. PMID: 38401486.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Effect of metformin and lifestyle intervention on adipokines and hormones in breast cancer survivors: a pooled analysis from two randomized controlled trials. Breast Cancer Res Treat. 2024 Jan 26. Johansson H, Bellerba F, Macis D, Bertelsen BE, Guerrieri-Gonzaga A, Aristarco V, Viste K, Mellgren G, Di Cola G, Costantino J, Scalbert A, Sears DD, Gandini S, DeCensi A, Bonanni B. PMID: 38279016.
      View in: PubMed   Mentions:    Fields:    
    4. Impact of Intermittent Fasting and/or Caloric Restriction on Aging-Related Outcomes in Adults: A Scoping Review of Randomized Controlled Trials. Nutrients. 2024 Jan 20; 16(2). James DL, Hawley NA, Mohr AE, Hermer J, Ofori E, Yu F, Sears DD. PMID: 38276554; PMCID: PMC10820472.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. The Combined Treatment with Ketogenic Diet and Metformin Slows Tumor Growth in Two Mouse Models of Triple Negative Breast Cancer. Res Sq. 2023 Dec 20. Schmidt K, Thatcher A, Grobe A, Hicks L, Gu H, Sears DD, Ellies LG, Kalachev L, Kroll E. PMID: 38196628; PMCID: PMC10775859.
      View in: PubMed   Mentions:
    6. Exploring the impact of environmental exposure changes on metabolic biomarkers: A 6-month GPS-GIS study among women with overweight or obesity. Environ Res. 2024 Feb 15; 243:117881. Letellier N, Yang JA, Alismail S, Nukavarapu N, Hartman SJ, Rock CL, Sears DD, Jankowska MM, Benmarhnia T. PMID: 38070847.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. Gut microbiome diversity, variability, and latent community types compared with shifts in body weight during the freshman year of college in dormitory-housed adolescents. Gut Microbes. 2023 12; 15(2):2250482. Mohr AE, Ahern MM, Sears DD, Bruening M, Whisner CM. PMID: 37642346; PMCID: PMC10467528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Objective sleep and cardiometabolic biomarkers: results from the community of mine study. Sleep Adv. 2023; 4(1):zpad052. Zamora S, Full KM, Ambeba E, Savin K, Crist K, Natarajan L, Sears DD, Alismail S, Letellier N, Benmarhnia T, Jankowska MM. PMID: 38107604; PMCID: PMC10721447.
      View in: PubMed   Mentions: 1  
    9. Mechanisms of improved body composition among perimenopausal women practicing Meditative Movement: a proposed biobehavioral model. Menopause. 2023 11 01; 30(11):1114-1123. James DL, Larkey LK, Evans B, Sebren A, Goldsmith K, Ahlich E, Hawley NA, Kechter A, Sears DD. PMID: 37788427.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Effects of Increased Standing and Light-Intensity Physical Activity to Improve Postprandial Glucose in Sedentary Office Workers: Protocol for a Randomized Crossover Trial. JMIR Res Protoc. 2023 Aug 23; 12:e45133. Wilson SL, Crosley-Lyons R, Junk J, Hasanaj K, Larouche ML, Hollingshead K, Gu H, Whisner C, Sears DD, Buman MP. PMID: 37610800; PMCID: PMC10483290.
      View in: PubMed   Mentions:
    11. WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity. Nutrients. 2023 Aug 04; 15(15). Lin D, Sturgeon KM, Gordon BR, Brown JC, Sears DD, Sarwer DB, Schmitz KH. PMID: 37571390; PMCID: PMC10421485.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Inflammatory Mediators and Type 2 Diabetes Risk Factors before and in Response to Lifestyle Intervention among Latino Adolescents with Obesity. Nutrients. 2023 May 24; 15(11). Peña A, Olson ML, Ayers SL, Sears DD, Vega-López S, Colburn AT, Shaibi GQ. PMID: 37299403; PMCID: PMC10255740.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Intermittent fasting interventions to leverage metabolic and circadian mechanisms for cancer treatment and supportive care outcomes. J Natl Cancer Inst Monogr. 2023 05 04; 2023(61):84-103. Kalam F, James DL, Li YR, Coleman MF, Kiesel VA, Cespedes Feliciano EM, Hursting SD, Sears DD, Kleckner AS. PMID: 37139971; PMCID: PMC10157769.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Translational and transdisciplinary research in energy balance and cancer: past is prologue. J Natl Cancer Inst Monogr. 2023 05 04; 2023(61):1-2. Irwin ML, Sears DD, Ligibel J. PMID: 37139974; PMCID: PMC10157745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Variable Eating Patterns: A Potential Novel Risk Factor for Systemic Inflammation in Women. Ann Behav Med. 2023 01 02; 57(1):93-97. Makarem N, Zuraikat FM, Caceres B, Sears DD, St-Onge MP, Lai Y, Aggarwal B. PMID: 35815757; PMCID: PMC9773363.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Metabolomic profiles of metformin in breast cancer survivors: a pooled analysis of plasmas from two randomized placebo-controlled trials. J Transl Med. 2022 12 29; 20(1):629. Bellerba F, Chatziioannou AC, Jasbi P, Robinot N, Keski-Rahkonen P, Trolat A, Vozar B, Hartman SJ, Scalbert A, Bonanni B, Johansson H, Sears DD, Gandini S. PMID: 36581893; PMCID: PMC9798585.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Longitudinal Associations Between Timing of Physical Activity Accumulation and Health: Application of Functional Data Methods. Stat Biosci. 2023 Jul; 15(2):309-329. Lin W, Zou J, Di C, Sears DD, Rock CL, Natarajan L. PMID: 37383028; PMCID: PMC10299778.
      View in: PubMed   Mentions: 2  
    18. WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Inflammation in Breast Cancer Survivors. Med Sci Sports Exerc. 2023 02 01; 55(2):209-215. Sturgeon KM, Brown JC, Sears DD, Sarwer DB, Schmitz KH. PMID: 36170550; PMCID: PMC9840668.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. How do environmental characteristics jointly contribute to cardiometabolic health? A quantile g-computation mixture analysis. Prev Med Rep. 2022 Dec; 30:102005. Letellier N, Zamora S, Yang JA, Sears DD, Jankowska MM, Benmarhnia T. PMID: 36245803; PMCID: PMC9562428.
      View in: PubMed   Mentions: 1  
    20. Multidimensional Sleep Health Is Associated with Cardiovascular Disease Prevalence and Cardiometabolic Health in US Adults. Int J Environ Res Public Health. 2022 08 29; 19(17). Makarem N, Alcantara C, Musick S, Quesada O, Sears DD, Chen Z, Tehranifar P. PMID: 36078471; PMCID: PMC9518578.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    22. Metabolites Associated With Fatigue and Physical Activity in Childhood Cancer. Biol Res Nurs. 2022 07; 24(3):350-361. Withycombe JS, Eldridge R, Jin Y, Gu H, Castellino SM, Sears DD. PMID: 35466716; PMCID: PMC9343883.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Air pollution and metabolic disorders: Dynamic versus static measures of exposure among Hispanics/Latinos and non-Hispanics. Environ Res. 2022 06; 209:112846. Letellier N, Zamora S, Spoon C, Yang JA, Mortamais M, Escobar GC, Sears DD, Jankowska MM, Benmarhnia T. PMID: 35120894; PMCID: PMC8976727.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    24. Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nat Commun. 2022 01 28; 13(1):565. Gao H, Luo Z, Ji Y, Tang K, Jin Z, Ly C, Sears DD, Mahata S, Ying W. PMID: 35091566; PMCID: PMC8799656.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors. Clin Epigenetics. 2021 12 17; 13(1):224. Nwanaji-Enwerem JC, Chung FF, Van der Laan L, Novoloaca A, Cuenin C, Johansson H, Bonanni B, Hubbard AE, Smith MT, Hartman SJ, Cardenas A, Sears DD, Herceg Z. PMID: 34920739; PMCID: PMC8684118.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. A Low-Glucose Eating Pattern Improves Biomarkers of Postmenopausal Breast Cancer Risk: An Exploratory Secondary Analysis of a Randomized Feasibility Trial. Nutrients. 2021 Dec 16; 13(12). Schembre SM, Jospe MR, Giles ED, Sears DD, Liao Y, Basen-Engquist KM, Thomson CA. PMID: 34960058; PMCID: PMC8707938.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice. J Clin Invest. 2021 11 01; 131(21). Mishra S, Sadagopan N, Dunkerly-Eyring B, Rodriguez S, Sarver DC, Ceddia RP, Murphy SA, Knutsdottir H, Jani VP, Ashok D, Oeing CU, O'Rourke B, Gangoiti JA, Sears DD, Wong GW, Collins S, Kass DA. PMID: 34618683; PMCID: PMC8553561.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Variability in Daily Eating Patterns and Eating Jetlag Are Associated With Worsened Cardiometabolic Risk Profiles in the American Heart Association Go Red for Women Strategically Focused Research Network. J Am Heart Assoc. 2021 09 21; 10(18):e022024. Makarem N, Sears DD, St-Onge MP, Zuraikat FM, Gallo LC, Talavera GA, Castaneda SF, Lai Y, Aggarwal B. PMID: 34482703; PMCID: PMC8649529.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    29. WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors. Nutrients. 2021 Sep 04; 13(9). D'Alonzo NJ, Qiu L, Sears DD, Chinchilli V, Brown JC, Sarwer DB, Schmitz KH, Sturgeon KM. PMID: 34578984; PMCID: PMC8469124.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Association Between Sugar-Sweetened Beverage Intake and Mortality Risk in Women: The California Teachers Study. J Acad Nutr Diet. 2022 02; 122(2):320-333.e6. Pacheco LS, Lacey JV, Martinez ME, Lemus H, Sears DD, Araneta MRG, Anderson CAM. PMID: 34389488; PMCID: PMC9001025.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women. Sci Rep. 2021 06 03; 11(1):11766. Chang YJ, Tuz-Zahra F, Godbole S, Avitia Y, Bellettiere J, Rock CL, Jankowska MM, Allison MA, Dunstan DW, Rana B, Natarajan L, Sears DD. PMID: 34083573; PMCID: PMC8175392.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial. JMIR Res Protoc. 2021 May 13; 10(5):e28684. Hartman SJ, Dillon LW, LaCroix AZ, Natarajan L, Sears DD, Owen N, Dunstan DW, Sallis JF, Schenk S, Allison M, Takemoto M, Herweck AM, Nguyen B, Rosenberg DE. PMID: 33983131; PMCID: PMC8160808.
      View in: PubMed   Mentions: 1  
    33. Device-Measured and Self-Reported Active Travel Associations with Cardiovascular Disease Risk Factors in an Ethnically Diverse Sample of Adults. Int J Environ Res Public Health. 2021 04 08; 18(8). Crist K, Benmarhnia T, Zamora S, Yang JA, Sears DD, Natarajan L, Dillon L, Sallis JF, Jankowska MM. PMID: 33917841; PMCID: PMC8068223.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. Recent advances and health implications of dietary fasting regimens on the gut microbiome. Am J Physiol Gastrointest Liver Physiol. 2021 05 01; 320(5):G847-G863. Mohr AE, Gumpricht E, Sears DD, Sweazea KL. PMID: 33729005.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    35. Go Red for Women Strategically Focused Research Network: Summary of Findings and Network Outcomes. J Am Heart Assoc. 2021 02; 10(5):e019519. St-Onge MP, Aggarwal B, Allison MA, Berger JS, Castañeda SF, Catov J, Hochman JS, Hubel CA, Jelic S, Kass DA, Makarem N, Michos ED, Mosca L, Ouyang P, Park C, Post WS, Powers RW, Reynolds HR, Sears DD, Shah SJ, Sharma K, Spruill T, Talavera GA, Vaidya D. PMID: 33619972; PMCID: PMC8174263.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    36. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Nat Commun. 2021 01 25; 12(1):565. Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, Mandt T, Newton IG, Kaur M, Sears DD, Webster NJG. PMID: 33495474; PMCID: PMC7835248.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    37. A randomized trial of physical activity for cognitive functioning in breast cancer survivors: Rationale and study design of I Can! Improving Cognition After Cancer. Contemp Clin Trials. 2021 03; 102:106289. Hartman SJ, Weiner LS, Natarajan L, Sears DD, Palmer BW, Parker B, Ahles T, Irwin ML, Au K. PMID: 33503496; PMCID: PMC8009833.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. Habitual Nightly Fasting Duration, Eating Timing, and Eating Frequency are Associated with Cardiometabolic Risk in Women. Nutrients. 2020 Oct 04; 12(10). Makarem N, Sears DD, St-Onge MP, Zuraikat FM, Gallo LC, Talavera GA, Castaneda SF, Lai Y, Mi J, Aggarwal B. PMID: 33020429; PMCID: PMC7599954.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    39. Diurnal patterns of sedentary behavior and changes in physical function over time among older women: a prospective cohort study. Int J Behav Nutr Phys Act. 2020 07 09; 17(1):88. Reuter C, Bellettiere J, Liles S, Di C, Sears DD, LaMonte MJ, Stefanick ML, LaCroix AZ, Natarajan L. PMID: 32646435; PMCID: PMC7346671.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    40. Sugar-Sweetened Beverage Intake and Cardiovascular Disease Risk in the California Teachers Study. J Am Heart Assoc. 2020 05 18; 9(10):e014883. Pacheco LS, Lacey JV, Martinez ME, Lemus H, Araneta MRG, Sears DD, Talavera GA, Anderson CAM. PMID: 32397792; PMCID: PMC7660873.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    41. Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers. J Am Heart Assoc. 2020 02 18; 9(4):e013403. Chang YJ, Bellettiere J, Godbole S, Keshavarz S, Maestas JP, Unkart JT, Ervin D, Allison MA, Rock CL, Patterson RE, Jankowska MM, Kerr J, Natarajan L, Sears DD. PMID: 32063113; PMCID: PMC7070209.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    42. Using Isotemporal Analyses to Examine the Relationships Between Daytime Activities and Cancer Recurrence Biomarkers in Breast Cancer Survivors. J Phys Act Health. 2020 02 01; 17(2):217-224. Full KM, Johnson E, Takemoto M, Hartman SJ, Kerr J, Natarajan L, Patterson RE, Sears DD. PMID: 31923899; PMCID: PMC7402374.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    43. Neighborhoods to Nucleotides - Advances and gaps for an obesity disparities systems epidemiology model. Curr Epidemiol Rep. 2019 Dec; 6(4):476-485. Jankowska MM, Gaulton K, Knight R, Patrick K, Sears DD. PMID: 36643055; PMCID: PMC9839192.
      View in: PubMed   Mentions: