Dorothy Sears

Title(s)Adjunct Professor, Family Medicine and Public Health
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Sedentary Behaviour Interrupted: Acute, medium and long-term effects on biomarkers of healthy aging, physical function and mortality
    NIH/NIA P01AG052352Jul 1, 2017 - May 31, 2022
    Role: Co-Investigator
    Time-Restricted Feeding and Breast Cancer
    NIH R01CA196853Apr 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    (PQA4) GPS exposure to environments & relations with biomarkers of cancer risk
    NIH/NCI R01CA179977Sep 1, 2013 - Aug 31, 2017
    Role: Co-Investigator
    Energetics & Breast Cancer: Obesity, Inflammation, Insulin Resistance & Risk
    NIH U54CA155435Jul 7, 2011 - May 31, 2017
    Role: Co-Investigator
    IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    NIH K01DK062025Sep 15, 2002 - Jun 30, 2006
    Role: Principal Investigator
    NOVEL INSULIN SIGNAL TRANSDUCTION PROTEINS
    NIH F32DK009595Jul 5, 1997
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gut microbiome diversity, variability, and latent community types compared with shifts in body weight during the freshman year of college in dormitory-housed adolescents. Gut Microbes. 2023 12; 15(2):2250482. Mohr AE, Ahern MM, Sears DD, Bruening M, Whisner CM. PMID: 37642346; PMCID: PMC10467528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Mechanisms of improved body composition among perimenopausal women practicing Meditative Movement: a proposed biobehavioral model. Menopause. 2023 Oct 03. James DL, Larkey LK, Evans B, Sebren A, Goldsmith K, Ahlich E, Hawley NA, Kechter A, Sears DD. PMID: 37788427.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Effects of Increased Standing and Light-Intensity Physical Activity to Improve Postprandial Glucose in Sedentary Office Workers: Protocol for a Randomized Crossover Trial. JMIR Res Protoc. 2023 Aug 23; 12:e45133. Wilson SL, Crosley-Lyons R, Junk J, Hasanaj K, Larouche ML, Hollingshead K, Gu H, Whisner C, Sears DD, Buman MP. PMID: 37610800; PMCID: PMC10483290.
      View in: PubMed   Mentions:
    4. WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Adiponectin and Leptin Levels in Breast Cancer Survivors with Overweight or Obesity. Nutrients. 2023 Aug 04; 15(15). Lin D, Sturgeon KM, Gordon BR, Brown JC, Sears DD, Sarwer DB, Schmitz KH. PMID: 37571390; PMCID: PMC10421485.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Inflammatory Mediators and Type 2 Diabetes Risk Factors before and in Response to Lifestyle Intervention among Latino Adolescents with Obesity. Nutrients. 2023 May 24; 15(11). Peña A, Olson ML, Ayers SL, Sears DD, Vega-López S, Colburn AT, Shaibi GQ. PMID: 37299403; PMCID: PMC10255740.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Intermittent fasting interventions to leverage metabolic and circadian mechanisms for cancer treatment and supportive care outcomes. J Natl Cancer Inst Monogr. 2023 05 04; 2023(61):84-103. Kalam F, James DL, Li YR, Coleman MF, Kiesel VA, Cespedes Feliciano EM, Hursting SD, Sears DD, Kleckner AS. PMID: 37139971; PMCID: PMC10157769.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Translational and transdisciplinary research in energy balance and cancer: past is prologue. J Natl Cancer Inst Monogr. 2023 05 04; 2023(61):1-2. Irwin ML, Sears DD, Ligibel J. PMID: 37139974; PMCID: PMC10157745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Variable Eating Patterns: A Potential Novel Risk Factor for Systemic Inflammation in Women. Ann Behav Med. 2023 01 02; 57(1):93-97. Makarem N, Zuraikat FM, Caceres B, Sears DD, St-Onge MP, Lai Y, Aggarwal B. PMID: 35815757; PMCID: PMC9773363.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Metabolomic profiles of metformin in breast cancer survivors: a pooled analysis of plasmas from two randomized placebo-controlled trials. J Transl Med. 2022 Dec 29; 20(1):629. Bellerba F, Chatziioannou AC, Jasbi P, Robinot N, Keski-Rahkonen P, Trolat A, Vozar B, Hartman SJ, Scalbert A, Bonanni B, Johansson H, Sears DD, Gandini S. PMID: 36581893.
      View in: PubMed   Mentions:    Fields:    
    10. Longitudinal Associations Between Timing of Physical Activity Accumulation and Health: Application of Functional Data Methods. Stat Biosci. 2023 Jul; 15(2):309-329. Lin W, Zou J, Di C, Sears DD, Rock CL, Natarajan L. PMID: 37383028; PMCID: PMC10299778.
      View in: PubMed   Mentions: 1  
    11. WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Inflammation in Breast Cancer Survivors. Med Sci Sports Exerc. 2023 02 01; 55(2):209-215. Sturgeon KM, Brown JC, Sears DD, Sarwer DB, Schmitz KH. PMID: 36170550; PMCID: PMC9840668.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. How do environmental characteristics jointly contribute to cardiometabolic health? A quantile g-computation mixture analysis. Prev Med Rep. 2022 Dec; 30:102005. Letellier N, Zamora S, Yang JA, Sears DD, Jankowska MM, Benmarhnia T. PMID: 36245803; PMCID: PMC9562428.
      View in: PubMed   Mentions:
    13. Multidimensional Sleep Health Is Associated with Cardiovascular Disease Prevalence and Cardiometabolic Health in US Adults. Int J Environ Res Public Health. 2022 08 29; 19(17). Makarem N, Alcantara C, Musick S, Quesada O, Sears DD, Chen Z, Tehranifar P. PMID: 36078471; PMCID: PMC9518578.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. Metabolites Associated With Fatigue and Physical Activity in Childhood Cancer. Biol Res Nurs. 2022 07; 24(3):350-361. Withycombe JS, Eldridge R, Jin Y, Gu H, Castellino SM, Sears DD. PMID: 35466716; PMCID: PMC9343883.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Air pollution and metabolic disorders: Dynamic versus static measures of exposure among Hispanics/Latinos and non-Hispanics. Environ Res. 2022 06; 209:112846. Letellier N, Zamora S, Spoon C, Yang JA, Mortamais M, Escobar GC, Sears DD, Jankowska MM, Benmarhnia T. PMID: 35120894; PMCID: PMC8976727.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    17. Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nat Commun. 2022 01 28; 13(1):565. Gao H, Luo Z, Ji Y, Tang K, Jin Z, Ly C, Sears DD, Mahata S, Ying W. PMID: 35091566; PMCID: PMC8799656.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors. Clin Epigenetics. 2021 12 17; 13(1):224. Nwanaji-Enwerem JC, Chung FF, Van der Laan L, Novoloaca A, Cuenin C, Johansson H, Bonanni B, Hubbard AE, Smith MT, Hartman SJ, Cardenas A, Sears DD, Herceg Z. PMID: 34920739; PMCID: PMC8684118.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. A Low-Glucose Eating Pattern Improves Biomarkers of Postmenopausal Breast Cancer Risk: An Exploratory Secondary Analysis of a Randomized Feasibility Trial. Nutrients. 2021 Dec 16; 13(12). Schembre SM, Jospe MR, Giles ED, Sears DD, Liao Y, Basen-Engquist KM, Thomson CA. PMID: 34960058; PMCID: PMC8707938.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice. J Clin Invest. 2021 11 01; 131(21). Mishra S, Sadagopan N, Dunkerly-Eyring B, Rodriguez S, Sarver DC, Ceddia RP, Murphy SA, Knutsdottir H, Jani VP, Ashok D, Oeing CU, O'Rourke B, Gangoiti JA, Sears DD, Wong GW, Collins S, Kass DA. PMID: 34618683; PMCID: PMC8553561.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Variability in Daily Eating Patterns and Eating Jetlag Are Associated With Worsened Cardiometabolic Risk Profiles in the American Heart Association Go Red for Women Strategically Focused Research Network. J Am Heart Assoc. 2021 09 21; 10(18):e022024. Makarem N, Sears DD, St-Onge MP, Zuraikat FM, Gallo LC, Talavera GA, Castaneda SF, Lai Y, Aggarwal B. PMID: 34482703; PMCID: PMC8649529.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    22. WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors. Nutrients. 2021 Sep 04; 13(9). D'Alonzo NJ, Qiu L, Sears DD, Chinchilli V, Brown JC, Sarwer DB, Schmitz KH, Sturgeon KM. PMID: 34578984; PMCID: PMC8469124.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Association Between Sugar-Sweetened Beverage Intake and Mortality Risk in Women: The California Teachers Study. J Acad Nutr Diet. 2022 02; 122(2):320-333.e6. Pacheco LS, Lacey JV, Martinez ME, Lemus H, Sears DD, Araneta MRG, Anderson CAM. PMID: 34389488; PMCID: PMC9001025.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women. Sci Rep. 2021 06 03; 11(1):11766. Chang YJ, Tuz-Zahra F, Godbole S, Avitia Y, Bellettiere J, Rock CL, Jankowska MM, Allison MA, Dunstan DW, Rana B, Natarajan L, Sears DD. PMID: 34083573; PMCID: PMC8175392.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial. JMIR Res Protoc. 2021 May 13; 10(5):e28684. Hartman SJ, Dillon LW, LaCroix AZ, Natarajan L, Sears DD, Owen N, Dunstan DW, Sallis JF, Schenk S, Allison M, Takemoto M, Herweck AM, Nguyen B, Rosenberg DE. PMID: 33983131; PMCID: PMC8160808.
      View in: PubMed   Mentions:
    26. Device-Measured and Self-Reported Active Travel Associations with Cardiovascular Disease Risk Factors in an Ethnically Diverse Sample of Adults. Int J Environ Res Public Health. 2021 04 08; 18(8). Crist K, Benmarhnia T, Zamora S, Yang JA, Sears DD, Natarajan L, Dillon L, Sallis JF, Jankowska MM. PMID: 33917841; PMCID: PMC8068223.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Recent advances and health implications of dietary fasting regimens on the gut microbiome. Am J Physiol Gastrointest Liver Physiol. 2021 05 01; 320(5):G847-G863. Mohr AE, Gumpricht E, Sears DD, Sweazea KL. PMID: 33729005.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    28. Go Red for Women Strategically Focused Research Network: Summary of Findings and Network Outcomes. J Am Heart Assoc. 2021 02; 10(5):e019519. St-Onge MP, Aggarwal B, Allison MA, Berger JS, Castañeda SF, Catov J, Hochman JS, Hubel CA, Jelic S, Kass DA, Makarem N, Michos ED, Mosca L, Ouyang P, Park C, Post WS, Powers RW, Reynolds HR, Sears DD, Shah SJ, Sharma K, Spruill T, Talavera GA, Vaidya D. PMID: 33619972; PMCID: PMC8174263.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Nat Commun. 2021 01 25; 12(1):565. Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, Mandt T, Newton IG, Kaur M, Sears DD, Webster NJG. PMID: 33495474; PMCID: PMC7835248.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    30. A randomized trial of physical activity for cognitive functioning in breast cancer survivors: Rationale and study design of I Can! Improving Cognition After Cancer. Contemp Clin Trials. 2021 03; 102:106289. Hartman SJ, Weiner LS, Natarajan L, Sears DD, Palmer BW, Parker B, Ahles T, Irwin ML, Au K. PMID: 33503496; PMCID: PMC8009833.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Habitual Nightly Fasting Duration, Eating Timing, and Eating Frequency are Associated with Cardiometabolic Risk in Women. Nutrients. 2020 Oct 04; 12(10). Makarem N, Sears DD, St-Onge MP, Zuraikat FM, Gallo LC, Talavera GA, Castaneda SF, Lai Y, Mi J, Aggarwal B. PMID: 33020429; PMCID: PMC7599954.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. Diurnal patterns of sedentary behavior and changes in physical function over time among older women: a prospective cohort study. Int J Behav Nutr Phys Act. 2020 07 09; 17(1):88. Reuter C, Bellettiere J, Liles S, Di C, Sears DD, LaMonte MJ, Stefanick ML, LaCroix AZ, Natarajan L. PMID: 32646435; PMCID: PMC7346671.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. Sugar-Sweetened Beverage Intake and Cardiovascular Disease Risk in the California Teachers Study. J Am Heart Assoc. 2020 05 18; 9(10):e014883. Pacheco LS, Lacey JV, Martinez ME, Lemus H, Araneta MRG, Sears DD, Talavera GA, Anderson CAM. PMID: 32397792; PMCID: PMC7660873.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    34. Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers. J Am Heart Assoc. 2020 02 18; 9(4):e013403. Chang YJ, Bellettiere J, Godbole S, Keshavarz S, Maestas JP, Unkart JT, Ervin D, Allison MA, Rock CL, Patterson RE, Jankowska MM, Kerr J, Natarajan L, Sears DD. PMID: 32063113; PMCID: PMC7070209.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    35. Using Isotemporal Analyses to Examine the Relationships Between Daytime Activities and Cancer Recurrence Biomarkers in Breast Cancer Survivors. J Phys Act Health. 2020 02 01; 17(2):217-224. Full KM, Johnson E, Takemoto M, Hartman SJ, Kerr J, Natarajan L, Patterson RE, Sears DD. PMID: 31923899; PMCID: PMC7402374.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Neighborhoods to Nucleotides - Advances and gaps for an obesity disparities systems epidemiology model. Curr Epidemiol Rep. 2019 Dec; 6(4):476-485. Jankowska MM, Gaulton K, Knight R, Patrick K, Sears DD. PMID: 36643055; PMCID: PMC9839192.
      View in: PubMed   Mentions:
    37. Mediators of a Physical Activity Intervention on Cognition in Breast Cancer Survivors: Evidence From a Randomized Controlled Trial. JMIR Cancer. 2019 Oct 11; 5(2):e13150. Hartman SJ, Weiner LS, Nelson SH, Natarajan L, Patterson RE, Palmer BW, Parker BA, Sears DD. PMID: 31605514; PMCID: PMC6914286.
      View in: PubMed   Mentions: 13  
    38. Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study. PLoS One. 2019; 14(10):e0223638. Pacheco LS, Anderson CAM, Lacey JV, Giovannucci EL, Lemus H, Araneta MRG, Sears DD, Talavera GA, Martinez ME. PMID: 31596902; PMCID: PMC6785057.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    39. A novel biomarker of cardiometabolic pathology in schizophrenia? J Psychiatr Res. 2019 10; 117:31-37. Lee EE, Sears DD, Liu J, Jin H, Tu XM, Eyler LT, Jeste DV. PMID: 31276836; PMCID: PMC6707833.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    40. Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention. J Cancer Surviv. 2019 06; 13(3):468-476. Weiner LS, Takemoto M, Godbole S, Nelson SH, Natarajan L, Sears DD, Hartman SJ. PMID: 31144265; PMCID: PMC6791122.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    41. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019 04 12; 364(6436). Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. PMID: 30975860; PMCID: PMC7580864.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansCells
    42. Association of Low Fasting Glucose and HbA1c With Cardiovascular Disease and Mortality: The MESA Study. J Endocr Soc. 2019 May 01; 3(5):892-901. Mongraw-Chaffin M, Bertoni AG, Golden SH, Mathioudakis N, Sears DD, Szklo M, Anderson CAM. PMID: 31020054; PMCID: PMC6469950.
      View in: PubMed   Mentions: 10  
    43. Protocol for a cross sectional study of cancer risk, environmental exposures and lifestyle behaviors in a diverse community sample: the Community of Mine study. BMC Public Health. 2019 Feb 13; 19(1):186. Jankowska MM, Sears DD, Natarajan L, Martinez E, Anderson CAM, Sallis JF, Matthews SA, Crist K, Dillon L, Johnson E, Barrera-Ng A, Full K, Godbole S, Kerr J. PMID: 30760246; PMCID: PMC6375220.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    44. Arriba por la Vida Estudio (AVE): Study protocol for a standing intervention targeting postmenopausal Latinas. Contemp Clin Trials. 2019 04; 79:66-72. Takemoto M, Schechtman M, Villa N, Talavera G, Sears DD, Natarajan L, Owen N, Rosenberg DE, Dunstan D, Allison M, Kerr J. PMID: 30771560.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    45. The Effects of Metformin and Weight Loss on Biomarkers Associated With Breast Cancer Outcomes. J Natl Cancer Inst. 2018 11 01; 110(11):1239-1247. Patterson RE, Marinac CR, Sears DD, Kerr J, Hartman SJ, Cadmus-Bertram L, Villaseñor A, Flatt SW, Godbole S, Li H, Laughlin GA, Oratowski-Coleman J, Parker BA, Natarajan L. PMID: 29788487; PMCID: PMC6235688.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    46. Associations of Sedentary Behavior and Abdominal Muscle Density: The Multi-Ethnic Study of Atherosclerosis. J Phys Act Health. 2018 11 01; 15(11):827-833. Vella CA, Michos ED, Sears DD, Cushman M, Van Hollebeke RB, Wiest MM, Allison MA. PMID: 30301405; PMCID: PMC7304496.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    47. Modeling interrelationships between health behaviors in overweight breast cancer survivors: Applying Bayesian networks. PLoS One. 2018; 13(9):e0202923. Xu S, Thompson W, Kerr J, Godbole S, Sears DD, Patterson R, Natarajan L. PMID: 30180192; PMCID: PMC6122792.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    48. AIBP protects against metabolic abnormalities and atherosclerosis. J Lipid Res. 2018 05; 59(5):854-863. Schneider DA, Choi SH, Agatisa-Boyle C, Zhu L, Kim J, Pattison J, Sears DD, Gordts PLSM, Fang L, Miller YI. PMID: 29559522; PMCID: PMC5928435.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    49. Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial. PLoS One. 2017; 12(11):e0188544. Kerr J, Crist K, Vital DG, Dillon L, Aden SA, Trivedi M, Castellanos LR, Godbole S, Li H, Allison MA, Khemlina GL, Takemoto ML, Schenk S, Sallis JF, Grace M, Dunstan DW, Natarajan L, LaCroix AZ, Sears DD. PMID: 29190761; PMCID: PMC5708739.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    50. Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond). 2018 04; 42(4):728-736. Hernandez-Carretero A, Weber N, La Frano MR, Ying W, Lantero Rodriguez J, Sears DD, Wallenius V, Börgeson E, Newman JW, Osborn O. PMID: 29089614; PMCID: PMC6055936.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    51. Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer. 2018 Jan 01; 124(1):192-202. Hartman SJ, Nelson SH, Myers E, Natarajan L, Sears DD, Palmer BW, Weiner LS, Parker BA, Patterson RE. PMID: 28926676; PMCID: PMC5735009.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    52. Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors. J Phys Act Health. 2018 01 01; 15(1):1-6. Hartman SJ, Marinac CR, Cadmus-Bertram L, Kerr J, Natarajan L, Godbole S, Patterson RE, Morey B, Sears DD. PMID: 28682735; PMCID: PMC5779627.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    53. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr. 2017 08 21; 37:371-393. Patterson RE, Sears DD. PMID: 28715993.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimals
    54. Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors. Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1078-1084. Jankowska MM, Natarajan L, Godbole S, Meseck K, Sears DD, Patterson RE, Kerr J. PMID: 28258052; PMCID: PMC5500421.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    55. A prospective study of low fasting glucose with cardiovascular disease events and all-cause mortality: The Women's Health Initiative. Metabolism. 2017 05; 70:116-124. Mongraw-Chaffin M, LaCroix AZ, Sears DD, Garcia L, Phillips LS, Salmoirago-Blotcher E, Zaslavsky O, Anderson CA. PMID: 28403935; PMCID: PMC5402725.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    56. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 11 03; 167(4):973-984.e12. Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. PMID: 27814523; PMCID: PMC5179329.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    57. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. PMID: 27832862; PMCID: PMC5123758.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    58. Prolonged Nightly Fasting and Breast Cancer Prognosis. JAMA Oncol. 2016 Aug 01; 2(8):1049-55. Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, Flatt SW, Sears DD, Patterson RE. PMID: 27032109; PMCID: PMC4982776.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    59. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253. Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE. PMID: 27394413; PMCID: PMC5071132.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    60. Impact of increasing physical activity on cognitive functioning in breast cancer survivors: Rationale and study design of Memory & Motion. Contemp Clin Trials. 2015 Nov; 45(Pt B):371-376. Hartman SJ, Natarajan L, Palmer BW, Parker B, Patterson RE, Sears DD. PMID: 26427563; PMCID: PMC4674350.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    61. Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk. PLoS One. 2015; 10(8):e0136240. Marinac CR, Sears DD, Natarajan L, Gallo LC, Breen CI, Patterson RE. PMID: 26305095; PMCID: PMC4549297.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    62. Gender and Age Differences in Hourly and Daily Patterns of Sedentary Time in Older Adults Living in Retirement Communities. PLoS One. 2015; 10(8):e0136161. Bellettiere J, Carlson JA, Rosenberg D, Singhania A, Natarajan L, Berardi V, LaCroix AZ, Sears DD, Moran K, Crist K, Kerr J. PMID: 26296095; PMCID: PMC4546658.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    63. Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009-2010). Cancer Epidemiol Biomarkers Prev. 2015 May; 24(5):783-9. Marinac CR, Natarajan L, Sears DD, Gallo LC, Hartman SJ, Arredondo E, Patterson RE. PMID: 25896523; PMCID: PMC4417458.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    64. Intermittent Fasting and Human Metabolic Health. J Acad Nutr Diet. 2015 Aug; 115(8):1203-12. Patterson RE, Laughlin GA, LaCroix AZ, Hartman SJ, Natarajan L, Senger CM, Martínez ME, Villaseñor A, Sears DD, Marinac CR, Gallo LC. PMID: 25857868; PMCID: PMC4516560.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimals
    65. Evaluation of the synuclein-γ (SNCG) gene as a PPARγ target in murine adipocytes, dorsal root ganglia somatosensory neurons, and human adipose tissue. PLoS One. 2015; 10(3):e0115830. Dunn TN, Akiyama T, Lee HW, Kim JB, Knotts TA, Smith SR, Sears DD, Carstens E, Adams SH. PMID: 25756178; PMCID: PMC4355072.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    66. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis. PLoS One. 2014; 9(9):e107658. Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears DD. PMID: 25251155; PMCID: PMC4175074.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    67. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. PMID: 25220417; PMCID: PMC4362785.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    68. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318; PMCID: PMC4109552.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    69. Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress. Mol Cell Biol. 2013 Jun; 33(12):2425-35. Ham M, Lee JW, Choi AH, Jang H, Choi G, Park J, Kozuka C, Sears DD, Masuzaki H, Kim JB. PMID: 23572562; PMCID: PMC3700093.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    70. The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design. Cancer Causes Control. 2013 Apr; 24(4):695-704. Patterson RE, Colditz GA, Hu FB, Schmitz KH, Ahima RS, Brownson RC, Carson KR, Chavarro JE, Chodosh LA, Gehlert S, Gill J, Glanz K, Haire-Joshu D, Herbst KL, Hoehner CM, Hovmand PS, Irwin ML, Jacobs LA, James AS, Jones LW, Kerr J, Kibel AS, King IB, Ligibel JA, Meyerhardt JA, Natarajan L, Neuhouser ML, Olefsky JM, Proctor EK, Redline S, Rock CL, Rosner B, Sarwer DB, Schwartz JS, Sears DD, Sesso HD, Stampfer MJ, Subramanian SV, Taveras EM, Tchou J, Thompson B, Troxel AB, Wessling-Resnick M, Wolin KY, Thornquist MD. PMID: 23378138; PMCID: PMC3602225.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    71. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013 Mar; 62(3):855-63. Qatanani M, Tan Y, Dobrin R, Greenawalt DM, Hu G, Zhao W, Olefsky JM, Sears DD, Kaplan LM, Kemp DM. PMID: 23223024; PMCID: PMC3581230.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    72. SirT1 regulates adipose tissue inflammation. Diabetes. 2011 Dec; 60(12):3235-45. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. PMID: 22110092; PMCID: PMC3219953.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    73. Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4):815-26. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. PMID: 22078880; PMCID: PMC3783197.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    74. Fat-induced inflammation unchecked. Cell Metab. 2010 Dec 01; 12(6):553-4. Osborn O, Sears DD, Olefsky JM. PMID: 21109185.
      View in: PubMed   Mentions: 7     Fields:    
    75. Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice. PLoS One. 2010 Nov 12; 5(11):e13959. Chapman J, Miles PD, Ofrecio JM, Neels JG, Yu JG, Resnik JL, Wilkes J, Talukdar S, Thapar D, Johnson K, Sears DD. PMID: 21103061; PMCID: PMC2980483.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    76. Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E164-74. Hsiao G, Chapman J, Ofrecio JM, Wilkes J, Resnik JL, Thapar D, Subramaniam S, Sears DD. PMID: 20959535; PMCID: PMC3023199.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    77. TLR4 and Insulin Resistance. Gastroenterol Res Pract. 2010; 2010. Kim JJ, Sears DD. PMID: 20814545; PMCID: PMC2931384.
      View in: PubMed   Mentions: 80  
    78. Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem. 2010 May 14; 285(20):15333-15345. Li P, Lu M, Nguyen MTA, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM. PMID: 20308074; PMCID: PMC2865288.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    79. Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans. PPAR Res. 2009; 2009:867678. Knotts TA, Lee HW, Kim JB, Oort PJ, McPherson R, Dent R, Tachibana K, Doi T, Yu S, Reddy JK, Uno K, Katagiri H, Pasarica M, Smith SR, Sears DD, Grino M, Adams SH. PMID: 20204174; PMCID: PMC2830574.
      View in: PubMed   Mentions: 8  
    80. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22504-9. Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky JM, Evans RM. PMID: 20018750; PMCID: PMC2794650.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    81. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18745-50. Sears DD, Hsiao G, Hsiao A, Yu JG, Courtney CH, Ofrecio JM, Chapman J, Subramaniam S. PMID: 19841271; PMCID: PMC2763882.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCellsCTClinical Trials
    82. 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice. PLoS One. 2009 Sep 29; 4(9):e7250. Sears DD, Miles PD, Chapman J, Ofrecio JM, Almazan F, Thapar D, Miller YI. PMID: 19787041; PMCID: PMC2746280.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    83. MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul; 23(7):975-88. Gregoire FM, Zhang F, Clarke HJ, Gustafson TA, Sears DD, Favelyukis S, Lenhard J, Rentzeperis D, Clemens LE, Mu Y, Lavan BE. PMID: 19389808; PMCID: PMC5419173.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    84. FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes. J Biol Chem. 2009 May 01; 284(18):12188-97. Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky JM. PMID: 19246449; PMCID: PMC2673287.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    85. Selective modulation of promoter recruitment and transcriptional activity of PPARgamma. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):515-21. Sears DD, Hsiao A, Ofrecio JM, Chapman J, He W, Olefsky JM. PMID: 17963725; PMCID: PMC2585742.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    86. The effects of intracellular calcium depletion on insulin signaling in 3T3-L1 adipocytes. Mol Endocrinol. 2002 Feb; 16(2):378-89. Worrall DS, Olefsky JM. PMID: 11818508.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    87. Increased instability of human CTG repeat tracts on yeast artificial chromosomes during gametogenesis. Mol Cell Biol. 1999 Jun; 19(6):4153-8. Cohen H, Sears DD, Zenvirth D, Hieter P, Simchen G. PMID: 10330155; PMCID: PMC104374.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    88. The legacy of Allan Hills 84001 Meteorit Planet Sci. 1998 Jul; 33(4):545-6. Sears D, Scott E, Warren P. PMID: 11543068.
      View in: PubMed   Mentions:
    89. Cis-acting determinants affecting centromere function, sister-chromatid cohesion and reciprocal recombination during meiosis in Saccharomyces cerevisiae. Genetics. 1995 Mar; 139(3):1159-73. Sears DD, Hegemann JH, Shero JH, Hieter P. PMID: 7768430; PMCID: PMC1206447.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    90. An implanted recombination hot spot stimulates recombination and enhances sister chromatid cohesion of heterologous YACs during yeast meiosis. Genetics. 1994 Dec; 138(4):1055-65. Sears DD, Hieter P, Simchen G. PMID: 7896090; PMCID: PMC1206247.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    91. Meiotic recombination and segregation of human-derived artificial chromosomes in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1992 Jun 15; 89(12):5296-300. Sears DD, Hegemann JH, Hieter P. PMID: 1608938; PMCID: PMC49278.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    92. The cytologic diagnosis of malignant neoplasms in pleural and peritoneal effusions. Acta Cytol. 1987 Mar-Apr; 31(2):85-97. Sears D, Hajdu SI. PMID: 3469856.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
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