Jianhua Shao

Title(s)	Professor, Pediatrics
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

research activities and funding

Alpha cell-derived Extracellular Vesicles and Maternal Insulin Production
NIH/NICHD 1R21HD112143-01May 8, 2023 - Apr 30, 2025
Role: Principal Investigator

Pancreatic alpha-cells and Maternal metabolic Adaptation
NIH/NICHD 1R21HD111199-01Apr 1, 2023 - Mar 31, 2025
Role: Principal Investigator

Brown adipose tissue development and fetal growth
NIH/NICHD R21HD107869Aug 19, 2022 - Jul 31, 2024
Role: Principal Investigator

Hypoadiponectinemia and Gestational Diabetes
NIH/NIDDK 2R01DK113007Dec 1, 2017 - Apr 30, 2028
Role: Principal Investigator

Hypoadiponectinemia and Gestational Diabetes
NIH R01DK113007Dec 1, 2017 - Nov 30, 2021

The maternal-fetal adiponectin differential and fetal fat deposition
NIH R01DK095132Aug 22, 2012 - Jun 30, 2022
Role: Principal Investigator

Adiponectin and fetal programming
NIH R01HD069634Feb 22, 2012 - Jan 31, 2018
Role: Principal Investigator

Center of Research in Obesity and Cardiovascular Disease (1P20 RR021954-01A1)
NIH P20RR021954Sep 8, 2008 - Jun 30, 2013
Role: Co-Investigator

Adiponectin and Regulation of Triglyceride Metabolism
NIH R01DK080418Apr 1, 2008 - Jan 31, 2014
Role: Principal Investigator

Fetal Adiponectin Expression /Obesity of Gestational Diabetes Mellitus Offspring
NIH R21DK077643Sep 15, 2006 - Sep 14, 2009
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Maternal GLP-1 receptor activation inhibits fetal growth. Am J Physiol Endocrinol Metab. 2024 Mar 01; 326(3):E268-E276. Qiao L, Lu C, Zang T, Dzyuba B, Shao J. PMID: 38197791; PMCID: PMC11193516.

View in: PubMed Mentions: 2 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals
The Essential Role of Pancreatic α-Cells in Maternal Metabolic Adaptation to Pregnancy. Diabetes. 2022 05 01; 71(5):978-988. Qiao L, Saget S, Lu C, Zang T, Dzyuba B, Hay WW, Shao J. PMID: 35147704; PMCID: PMC9044124.

View in: PubMed Mentions: 7 Fields:
End Endocrinology
Translation:Animals Cells
Adiponectin Promotes Maternal β-Cell Expansion Through Placental Lactogen Expression. Diabetes. 2021 01; 70(1):132-142. Qiao L, Saget S, Lu C, Hay WW, Karsenty G, Shao J. PMID: 33087456; PMCID: PMC7881845.

View in: PubMed Mentions: 14 Fields:
End Endocrinology
Translation:Humans Animals Cells
Obesity Reduces Maternal Blood Triglyceride Concentrations by Reducing Angiopoietin-Like Protein 4 Expression in Mice. Diabetes. 2020 06; 69(6):1100-1109. Qiao L, Shetty SK, Spitler KM, Wattez JS, Davies BSJ, Shao J. PMID: 32051149; PMCID: PMC7243287.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Translation:Animals
Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal β-Cell Development in C57BL/6 Mice. Diabetes. 2019 08; 68(8):1604-1613. Qiao L, Wattez JS, Lim L, Rozance PJ, Hay WW, Shao J. PMID: 31127056; PMCID: PMC6692812.

View in: PubMed Mentions: 11 Fields:
End Endocrinology
Translation:Animals Cells
The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta. Dev Dyn. 2019 05; 248(5):363-374. Wattez JS, Qiao L, Lee S, Natale DRC, Shao J. PMID: 30843624; PMCID: PMC6488356.

View in: PubMed Mentions: 9 Fields:
Ana Anatomy
Translation:Animals Cells
High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice. Int J Obes (Lond). 2019 09; 43(9):1747-1758. Qiao L, Chu K, Wattez JS, Lee S, Gao H, Feng GS, Hay WW, Shao J. PMID: 30622311; PMCID: PMC6614019.

View in: PubMed Mentions: 8 Fields:
Met Metabolism
Translation:Animals
Regulatory effects of brown adipose tissue thermogenesis on maternal metabolic adaptation, placental efficiency, and fetal growth in mice. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1224-E1231. Qiao L, Lee S, Nguyen A, Hay WW, Shao J. PMID: 30277793; PMCID: PMC6336951.

View in: PubMed Mentions: 7 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals
Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. Diabetes. 2017 05; 66(5):1126-1135. Qiao L, Wattez JS, Lee S, Nguyen A, Schaack J, Hay WW, Shao J. PMID: 28073830; PMCID: PMC5399613.

View in: PubMed Mentions: 38 Fields:
End Endocrinology
Translation:Animals Cells
Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1. Diabetologia. 2016 11; 59(11):2417-2425. Qiao L, Wattez JS, Lee S, Guo Z, Schaack J, Hay WW, Zita MM, Parast M, Shao J. PMID: 27495989; PMCID: PMC5042853.

View in: PubMed Mentions: 29 Fields:
End Endocrinology
Translation:Humans Animals Cells
Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis. J Cachexia Sarcopenia Muscle. 2016 05; 7(2):152-64. Cheung WW, Cherqui S, Ding W, Esparza M, Zhou P, Shao J, Lieber RL, Mak RH. PMID: 27493869; PMCID: PMC4864942.

View in: PubMed Mentions: 16 Fields:
Neo Neoplasms Pat Pathology
Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice. Diabetes. 2015 Sep; 64(9):3111-20. Qiao L, Guo Z, Bosco C, Guidotti S, Wang Y, Wang M, Parast M, Schaack J, Hay WW, Moore TR, Shao J. PMID: 25948680; PMCID: PMC4542442.

View in: PubMed Mentions: 35 Fields:
End Endocrinology
Translation:Humans Animals Cells PHPublic Health
Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. PMID: 25876076; PMCID: PMC4395342.

View in: PubMed Mentions: 6 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 05; 20(2):320-32. Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. PMID: 24981838; PMCID: PMC4365973.

View in: PubMed Mentions: 44 Fields:
Cel Cell Biology Met Metabolism
Translation:Animals Cells
Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One. 2014; 9(6):e99575. Lee B, Qiao L, Kinney B, Feng GS, Shao J. PMID: 24911652; PMCID: PMC4049836.

View in: PubMed Mentions: 17 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Adiponectin and energy homeostasis. Rev Endocr Metab Disord. 2014 Jun; 15(2):149-56. Lee B, Shao J. PMID: 24170312; PMCID: PMC4006341.

View in: PubMed Mentions: 76 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. PMID: 24789228; PMCID: PMC4008632.

View in: PubMed Mentions: 14 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
C/EBPα regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. PMID: 24691027; PMCID: PMC4025063.

View in: PubMed Mentions: 30 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. PMID: 24531262; PMCID: PMC4077285.

View in: PubMed Mentions: 41 Fields:
End Endocrinology
Translation:Animals Cells
Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E79-88. He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. PMID: 23236157; PMCID: PMC3538237.

View in: PubMed Mentions: 28 Fields:
Sci Science
Translation:Animals Cells
Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012 Dec; 61(12):3199-207. Qiao L, Yoo HS, Madon A, Kinney B, Hay WW, Shao J. PMID: 22872236; PMCID: PMC3501876.

View in: PubMed Mentions: 25 Fields:
End Endocrinology
Translation:Animals
Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1. Diabetes. 2012 Jun; 61(6):1463-70. Qiao L, Kinney B, Yoo HS, Lee B, Schaack J, Shao J. PMID: 22415879; PMCID: PMC3357265.

View in: PubMed Mentions: 42 Fields:
End Endocrinology
Translation:Animals Cells
Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes. 2011 May; 60(5):1519-27. Qiao L, Kinney B, Schaack J, Shao J. PMID: 21430087; PMCID: PMC3292326.

View in: PubMed Mentions: 54 Fields:
End Endocrinology
Translation:Animals Cells
Energy intake and adiponectin gene expression. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E809-16. Qiao L, Lee B, Kinney B, Yoo HS, Shao J. PMID: 21325106; PMCID: PMC3093972.

View in: PubMed Mentions: 22 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice. Endocrinology. 2010 Aug; 151(8):3624-32. Kinney BP, Qiao L, Levaugh JM, Shao J. PMID: 20534721; PMCID: PMC2940515.

View in: PubMed Mentions: 10 Fields:
End Endocrinology
Translation:Humans Animals Cells