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Jianhua Shao

Title(s)Professor In Residence, Pediatrics
SchoolHealth Sciences
Phone858-822-1969
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    Collapse Research 
    Collapse Research Activities and Funding
    Hypoadiponectinemia and Gestational Diabetes
    NIH/NIDDK R01DK113007Dec 1, 2017 - Nov 30, 2021
    Role: Principal Investigator
    The maternal-fetal adiponectin differential and fetal fat deposition
    NIH/NIDDK R01DK095132Aug 22, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Adiponectin and fetal programming
    NIH/NICHD R01HD069634Feb 22, 2012 - Jan 31, 2017
    Role: Principal Investigator
    Center of Research in Obesity and Cardiovascular Disease (1P20 RR021954-01A1)
    NIH P20RR021954Sep 8, 2008 - Jun 30, 2013
    Role: Co-Investigator
    Adiponectin and Regulation of Triglyceride Metabolism
    NIH/NIDDK R01DK080418Apr 1, 2008 - Jun 30, 2009
    Role: Principal Investigator
    Fetal Adiponectin Expression /Obesity of Gestational Diabetes Mellitus Offspring
    NIH/NIDDK R21DK077643Sep 15, 2006 - Sep 14, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Qiao L, Shetty SK, Spitler KM, Wattez JS, Davies BSJ, Shao J. Obesity Reduces Maternal Blood Triglyceride Concentrations by Reducing Angiopoietin-like Protein 4 Expression in Mice. Diabetes. 2020 Feb 12. PMID: 32051149.
      View in: PubMed
    2. Qiao L, Wattez JS, Lim L, Rozance PJ, Hay WW, Shao J. Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal ß-Cell Development in C57BL/6 Mice. Diabetes. 2019 08; 68(8):1604-1613. PMID: 31127056.
      View in: PubMed
    3. Wattez JS, Qiao L, Lee S, Natale DRC, Shao J. The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta. Dev Dyn. 2019 05; 248(5):363-374. PMID: 30843624.
      View in: PubMed
    4. Qiao L, Chu K, Wattez JS, Lee S, Gao H, Feng GS, Hay WW, Shao J. High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice. Int J Obes (Lond). 2019 09; 43(9):1747-1758. PMID: 30622311.
      View in: PubMed
    5. Qiao L, Lee S, Nguyen A, Hay WW, Shao J. Regulatory effects of brown adipose tissue thermogenesis on maternal metabolic adaptation, placental efficiency, and fetal growth in mice. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1224-E1231. PMID: 30277793.
      View in: PubMed
    6. Qiao L, Wattez JS, Lee S, Nguyen A, Schaack J, Hay WW, Shao J. Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. Diabetes. 2017 05; 66(5):1126-1135. PMID: 28073830.
      View in: PubMed
    7. Qiao L, Wattez JS, Lee S, Guo Z, Schaack J, Hay WW, Zita MM, Parast M, Shao J. Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1. Diabetologia. 2016 11; 59(11):2417-2425. PMID: 27495989.
      View in: PubMed
    8. Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW. The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice. Diabetologia. 2016 Mar; 59(3):582-91. PMID: 26631215.
      View in: PubMed
    9. Cheung WW, Cherqui S, Ding W, Esparza M, Zhou P, Shao J, Lieber RL, Mak RH. Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis. J Cachexia Sarcopenia Muscle. 2016 05; 7(2):152-64. PMID: 27493869.
      View in: PubMed
    10. Qiao L, Guo Z, Bosco C, Guidotti S, Wang Y, Wang M, Parast M, Schaack J, Hay WW, Moore TR, Shao J. Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice. Diabetes. 2015 Sep; 64(9):3111-20. PMID: 25948680.
      View in: PubMed
    11. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. PMID: 25876076.
      View in: PubMed
    12. Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 05; 20(2):320-32. PMID: 24981838.
      View in: PubMed
    13. Lee B, Qiao L, Kinney B, Feng GS, Shao J. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One. 2014; 9(6):e99575. PMID: 24911652.
      View in: PubMed
    14. Lee B, Shao J. Adiponectin and energy homeostasis. Rev Endocr Metab Disord. 2014 Jun; 15(2):149-56. PMID: 24170312.
      View in: PubMed
    15. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. PMID: 24789228.
      View in: PubMed
    16. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. PMID: 24691027.
      View in: PubMed
    17. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. PMID: 24531262.
      View in: PubMed
    18. He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E79-88. PMID: 23236157.
      View in: PubMed
    19. Qiao L, Yoo HS, Madon A, Kinney B, Hay WW, Shao J. Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012 Dec; 61(12):3199-207. PMID: 22872236.
      View in: PubMed
    20. Qiao L, Kinney B, Yoo HS, Lee B, Schaack J, Shao J. Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1. Diabetes. 2012 Jun; 61(6):1463-70. PMID: 22415879.
      View in: PubMed
    21. Qiao L, Kinney B, Schaack J, Shao J. Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes. 2011 May; 60(5):1519-27. PMID: 21430087.
      View in: PubMed
    22. Qiao L, Lee B, Kinney B, Yoo HS, Shao J. Energy intake and adiponectin gene expression. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E809-16. PMID: 21325106.
      View in: PubMed
    23. Schaack J, Qiao L, Walkiewicz MP, Stonehouse M, Engel DA, Vazquez-Torres A, Nordeen SK, Shao J, Moorhead JW. Insertion of CTCF-binding sites into a first-generation adenovirus vector reduces the innate inflammatory response and prolongs transgene expression. Virology. 2011 Mar 30; 412(1):136-45. PMID: 21272906.
      View in: PubMed
    24. Kinney BP, Qiao L, Levaugh JM, Shao J. B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice. Endocrinology. 2010 Aug; 151(8):3624-32. PMID: 20534721.
      View in: PubMed
    25. Qiao L, Zou C, van der Westhuyzen DR, Shao J. Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism. Diabetes. 2008 Jul; 57(7):1824-33. PMID: 18375436.
      View in: PubMed
    26. Qiao L, Zou C, Shao P, Schaack J, Johnson PF, Shao J. Transcriptional regulation of fatty acid translocase/CD36 expression by CCAAT/enhancer-binding protein alpha. J Biol Chem. 2008 Apr 04; 283(14):8788-95. PMID: 18263877.
      View in: PubMed
    27. Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE. CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem. 2007 May 25; 282(21):15717-29. PMID: 17387171.
      View in: PubMed
    28. Qiao L, Shao J. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem. 2006 Dec 29; 281(52):39915-24. PMID: 17090532.
      View in: PubMed
    29. Qiao L, MacDougald OA, Shao J. CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase. J Biol Chem. 2006 Aug 25; 281(34):24390-7. PMID: 16807249.
      View in: PubMed
    30. Qiao L, MacLean PS, You H, Schaack J, Shao J. knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology. 2006 Jun; 147(6):3060-9. PMID: 16543372.
      View in: PubMed
    31. Qiao L, Schaack J, Shao J. Suppression of adiponectin gene expression by histone deacetylase inhibitor valproic acid. Endocrinology. 2006 Feb; 147(2):865-74. PMID: 16282359.
      View in: PubMed
    32. Qiao L, Maclean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti M, Friedman JE, Shao J. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes. 2005 Jun; 54(6):1744-54. PMID: 15919796.
      View in: PubMed
    33. Shao J, Qiao L, Janssen RC, Pagliassotti M, Friedman JE. Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio. Diabetes. 2005 Apr; 54(4):976-84. PMID: 15793235.
      View in: PubMed
    34. Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. 2004 Mar; 145(3):1144-50. PMID: 14633976.
      View in: PubMed
    35. Shao J, Qiao L, Friedman JE. Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 beta-cells. Am J Physiol Endocrinol Metab. 2004 Feb; 286(2):E304-10. PMID: 14559722.
      View in: PubMed
    36. Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res. 2003 Mar; 53(3):411-8. PMID: 12595588.
      View in: PubMed
    37. Barbour LA, Shao J, Qiao L, Pulawa LK, Jensen DR, Bartke A, Garrity M, Draznin B, Friedman JE. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol. 2002 Mar; 186(3):512-7. PMID: 11904616.
      View in: PubMed
    38. Catalano PM, Nizielski SE, Shao J, Preston L, Qiao L, Friedman JE. Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. Am J Physiol Endocrinol Metab. 2002 Mar; 282(3):E522-33. PMID: 11832353.
      View in: PubMed
    39. Shao J, Yamashita H, Qiao L, Draznin B, Friedman JE. Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus. Diabetes. 2002 Jan; 51(1):19-29. PMID: 11756318.
      View in: PubMed
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