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Jianhua Shao

Title(s)Professor In Residence, Pediatrics
SchoolHealth Sciences
Address9500 Gilman Drive #0983
La Jolla CA 92093
Phone858-822-1969
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    Collapse Research 
    Collapse Research Activities and Funding
    Hypoadiponectinemia and Gestational Diabetes
    NIH/NIDDK R01DK113007Dec 1, 2017 - Nov 30, 2021
    Role: Principal Investigator
    The maternal-fetal adiponectin differential and fetal fat deposition
    NIH/NIDDK R01DK095132Aug 22, 2012 - Jun 30, 2022
    Role: Principal Investigator
    Adiponectin and fetal programming
    NIH/NICHD R01HD069634Feb 22, 2012 - Jan 31, 2017
    Role: Principal Investigator
    Center of Research in Obesity and Cardiovascular Disease (1P20 RR021954-01A1)
    NIH P20RR021954Sep 8, 2008 - Jun 30, 2013
    Role: Co-Investigator
    Adiponectin and Regulation of Triglyceride Metabolism
    NIH/NIDDK R01DK080418Apr 1, 2008 - Jun 30, 2009
    Role: Principal Investigator
    Fetal Adiponectin Expression /Obesity of Gestational Diabetes Mellitus Offspring
    NIH/NIDDK R21DK077643Sep 15, 2006 - Sep 14, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Obesity Reduces Maternal Blood Triglyceride Concentrations by Reducing Angiopoietin-Like Protein 4 Expression in Mice. Diabetes. 2020 Jun; 69(6):1100-1109. Qiao L, Shetty SK, Spitler KM, Wattez JS, Davies BSJ, Shao J. PMID: 32051149.
      View in: PubMed   Mentions: 1     Fields:    
    2. Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal ß-Cell Development in C57BL/6 Mice. Diabetes. 2019 08; 68(8):1604-1613. Qiao L, Wattez JS, Lim L, Rozance PJ, Hay WW, Shao J. PMID: 31127056.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta. Dev Dyn. 2019 05; 248(5):363-374. Wattez JS, Qiao L, Lee S, Natale DRC, Shao J. PMID: 30843624.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. High-fat feeding reprograms maternal energy metabolism and induces long-term postpartum obesity in mice. Int J Obes (Lond). 2019 09; 43(9):1747-1758. Qiao L, Chu K, Wattez JS, Lee S, Gao H, Feng GS, Hay WW, Shao J. PMID: 30622311.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Regulatory effects of brown adipose tissue thermogenesis on maternal metabolic adaptation, placental efficiency, and fetal growth in mice. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1224-E1231. Qiao L, Lee S, Nguyen A, Hay WW, Shao J. PMID: 30277793.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Adiponectin Deficiency Impairs Maternal Metabolic Adaptation to Pregnancy in Mice. Diabetes. 2017 05; 66(5):1126-1135. Qiao L, Wattez JS, Lee S, Nguyen A, Schaack J, Hay WW, Shao J. PMID: 28073830.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    7. Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1. Diabetologia. 2016 11; 59(11):2417-2425. Qiao L, Wattez JS, Lee S, Guo Z, Schaack J, Hay WW, Zita MM, Parast M, Shao J. PMID: 27495989.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice. Diabetologia. 2016 Mar; 59(3):582-91. Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW. PMID: 26631215.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis. J Cachexia Sarcopenia Muscle. 2016 05; 7(2):152-64. Cheung WW, Cherqui S, Ding W, Esparza M, Zhou P, Shao J, Lieber RL, Mak RH. PMID: 27493869.
      View in: PubMed   Mentions: 3     Fields:    
    10. Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice. Diabetes. 2015 Sep; 64(9):3111-20. Qiao L, Guo Z, Bosco C, Guidotti S, Wang Y, Wang M, Parast M, Schaack J, Hay WW, Moore TR, Shao J. PMID: 25948680.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. PLoS One. 2015; 10(4):e0122948. Zhong L, Yeh TY, Hao J, Pourtabatabaei N, Mahata SK, Shao J, Chessler SD, Chi NW. PMID: 25876076.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 05; 20(2):320-32. Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. PMID: 24981838.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    13. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One. 2014; 9(6):e99575. Lee B, Qiao L, Kinney B, Feng GS, Shao J. PMID: 24911652.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Adiponectin and energy homeostasis. Rev Endocr Metab Disord. 2014 Jun; 15(2):149-56. Lee B, Shao J. PMID: 24170312.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    15. Intermittent cold exposure enhances fat accumulation in mice. PLoS One. 2014; 9(5):e96432. Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. PMID: 24789228.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. C/EBPa regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1144-54. Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. PMID: 24691027.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    17. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia. 2014 May; 57(5):1027-36. Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. PMID: 24531262.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    18. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):E79-88. He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. PMID: 23236157.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    19. Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012 Dec; 61(12):3199-207. Qiao L, Yoo HS, Madon A, Kinney B, Hay WW, Shao J. PMID: 22872236.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    20. Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1. Diabetes. 2012 Jun; 61(6):1463-70. Qiao L, Kinney B, Yoo HS, Lee B, Schaack J, Shao J. PMID: 22415879.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    21. Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes. 2011 May; 60(5):1519-27. Qiao L, Kinney B, Schaack J, Shao J. PMID: 21430087.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    22. Energy intake and adiponectin gene expression. Am J Physiol Endocrinol Metab. 2011 May; 300(5):E809-16. Qiao L, Lee B, Kinney B, Yoo HS, Shao J. PMID: 21325106.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Insertion of CTCF-binding sites into a first-generation adenovirus vector reduces the innate inflammatory response and prolongs transgene expression. Virology. 2011 Mar 30; 412(1):136-45. Schaack J, Qiao L, Walkiewicz MP, Stonehouse M, Engel DA, Vazquez-Torres A, Nordeen SK, Shao J, Moorhead JW. PMID: 21272906.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice. Endocrinology. 2010 Aug; 151(8):3624-32. Kinney BP, Qiao L, Levaugh JM, Shao J. PMID: 20534721.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    25. Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism. Diabetes. 2008 Jul; 57(7):1824-33. Qiao L, Zou C, van der Westhuyzen DR, Shao J. PMID: 18375436.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    26. Transcriptional regulation of fatty acid translocase/CD36 expression by CCAAT/enhancer-binding protein alpha. J Biol Chem. 2008 Apr 04; 283(14):8788-95. Qiao L, Zou C, Shao P, Schaack J, Johnson PF, Shao J. PMID: 18263877.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem. 2007 May 25; 282(21):15717-29. Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE. PMID: 17387171.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    28. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem. 2006 Dec 29; 281(52):39915-24. Qiao L, Shao J. PMID: 17090532.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    29. CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase. J Biol Chem. 2006 Aug 25; 281(34):24390-7. Qiao L, MacDougald OA, Shao J. PMID: 16807249.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    30. knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice. Endocrinology. 2006 Jun; 147(6):3060-9. Qiao L, MacLean PS, You H, Schaack J, Shao J. PMID: 16543372.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. Suppression of adiponectin gene expression by histone deacetylase inhibitor valproic acid. Endocrinology. 2006 Feb; 147(2):865-74. Qiao L, Schaack J, Shao J. PMID: 16282359.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    32. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes. 2005 Jun; 54(6):1744-54. Qiao L, Maclean PS, Schaack J, Orlicky DJ, Darimont C, Pagliassotti M, Friedman JE, Shao J. PMID: 15919796.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    33. Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio. Diabetes. 2005 Apr; 54(4):976-84. Shao J, Qiao L, Janssen RC, Pagliassotti M, Friedman JE. PMID: 15793235.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    34. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. 2004 Mar; 145(3):1144-50. Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B. PMID: 14633976.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    35. Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 beta-cells. Am J Physiol Endocrinol Metab. 2004 Feb; 286(2):E304-10. Shao J, Qiao L, Friedman JE. PMID: 14559722.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    36. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res. 2003 Mar; 53(3):411-8. Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE. PMID: 12595588.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol. 2002 Mar; 186(3):512-7. Barbour LA, Shao J, Qiao L, Pulawa LK, Jensen DR, Bartke A, Garrity M, Draznin B, Friedman JE. PMID: 11904616.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    38. Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. Am J Physiol Endocrinol Metab. 2002 Mar; 282(3):E522-33. Catalano PM, Nizielski SE, Shao J, Preston L, Qiao L, Friedman JE. PMID: 11832353.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    39. Phosphatidylinositol 3-kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus. Diabetes. 2002 Jan; 51(1):19-29. Shao J, Yamashita H, Qiao L, Draznin B, Friedman JE. PMID: 11756318.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
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