Scott Biering

Title(s)Assistant Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Elucidating the roles of the beta-2 adrenergic receptor and epidermal growth factor receptor in flavivirus NS1-mediated endothelial dysfunction
    NIH K22AI170797Mar 1, 2024 - Feb 28, 2026
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-dependent STING activation. Cell Rep. 2026 Oct 27; 45(10):118154. Vo PTT, Cicero J, Wang Z, Hakozaki H, Hoang TS, Adame-Garcia SR, Ramms DJ, Sato K, Stevenson E, Zhou Y, Fan K, Bokor JA, Kril V, Schiavon C, Biering SB, Swaney DL, Krogan NJ, Schöneberg J, Manor U, Gutkind JS. PMID: 42886558.
      View in: PubMed   Mentions:
    2. The contribution of viral toxins to infection and pathogenesis. mBio. 2026 04 08; 17(4):e0042125. Biering SB, Puerta-Guardo H, Pahmeier F, Kril V, Harris E. PMID: 41823417; PMCID: PMC13059731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination. PLoS Pathog. 2025 12; 21(12):e1013811. Puerta-Guardo H, Biering SB, Castillo-Rojas B, DiBiasio-White MJ, Lo NTN, Espinosa DA, Warnes CM, Wang C, Cao TM, Glasner DR, Beatty PR, Kuhn RJ, Harris E. PMID: 41474801; PMCID: PMC12779140.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Dengue Virus NS1 Binds Ephrin B1 to Trigger Endothelial Dysfunction. bioRxiv. 2025 Nov 19. Pahmeier F, Hammond SR, Flory C, Feng X, Lee SE, Jimenez-Posada EV, Duarte EM, Cardona-Ospina JA, Ball AH, Lee NE, Leung K, Tjang LV, Beatty PR, Biering SB, Scaturro P, Harris E. PMID: 41332748; PMCID: PMC12668011.
      View in: PubMed   Mentions:
    5. Therapeutic Potential of Cyclodextrins Targeting Dengue Virus and SARS-CoV-2 Infection and Pathogenesis. bioRxiv. 2025 Aug 04. Carneiro PH, Jimenez-Posada EV, de Sousa FTG, Biering SB, Patel TS, Bhat S, Stanley S, Pak J, Laing P, Sohajda T, Harris E, Beatty PR. PMID: 40799540; PMCID: PMC12340814.
      View in: PubMed   Mentions:
    6. Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread. Sci Transl Med. 2025 02 19; 17(786):eadq5928. Pahmeier F, Monticelli SR, Feng X, Hjorth CK, Wang A, Kuehne AI, Bakken RR, Batchelor TG, Lee SE, Middlecamp M, Stuart L, Duarte-Neto AN, Abelson DM, McLellan JS, Biering SB, Herbert AS, Chandran K, Harris E. PMID: 39970234; PMCID: PMC12095872.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1. EBioMedicine. 2024 Nov; 109:105409. de Sousa FTG, Warnes CM, Manuli ER, Tjang LV, Carneiro PH, Maria de Oliveira Pinto L, Ng A, Bhat S, Zambrana JV, D'Elia Zanella LGFAB, Ho YL, Romano CM, Beatty PR, Biering SB, Kallas EG, Sabino EC, Harris E. PMID: 39454515; PMCID: PMC11539239.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread. bioRxiv. 2024 May 23. Pahmeier F, Monticelli SR, Feng X, Hjorth CK, Wang A, Kuehne AI, Bakken RR, Batchelor TG, Lee SE, Middlecamp M, Stuart L, Abelson DM, McLellan JS, Biering SB, Herbert AS, Chandran K, Harris E. PMID: 38826290; PMCID: PMC11142176.
      View in: PubMed   Mentions:
    9. The inflammasome pathway is activated by dengue virus non-structural protein 1 and is protective during dengue virus infection. PLoS Pathog. 2024 04; 20(4):e1012167. Wong MP, Juan EYW, Pahmeier F, Chelluri SS, Wang P, Castillo-Rojas B, Blanc SF, Biering SB, Vance RE, Harris E. PMID: 38662771; PMCID: PMC11075848.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Rapid detection of SARS-CoV-2 RNA in saliva via Cas13. Nat Biomed Eng. 2022 08; 6(8):944-956. Chandrasekaran SS, Agrawal S, Fanton A, Jangid AR, Charrez B, Escajeda AM, Son S, Mcintosh R, Tran H, Bhuiya A, de León Derby MD, Switz NA, Armstrong M, Harris AR, Prywes N, Lukarska M, Biering SB, Smock DCJ, Mok A, Knott GJ, Dang Q, Van Dis E, Dugan E, Kim S, Liu TY, IGI Testing Consortium, Moehle EA, Kogut K, Eskenazi B, Harris E, Stanley SA, Lareau LF, Tan MX, Fletcher DA, Doudna JA, Savage DF, Hsu PD. PMID: 35953650; PMCID: PMC10367768.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    11. An intranasal ASO therapeutic targeting SARS-CoV-2. Nat Commun. 2022 08 03; 13(1):4503. Zhu C, Lee JY, Woo JZ, Xu L, Wrynla XH, Yamashiro LH, Ji F, Biering SB, Van Dis E, Gonzalez F, Fox D, Wehri E, Rustagi A, Pinsky BA, Schaletzky J, Blish CA, Chiu C, Harris E, Sadreyev RI, Stanley S, Kauppinen S, Rouskin S, Näär AM. PMID: 35922434; PMCID: PMC9349213.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    12. Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. Nat Genet. 2022 08; 54(8):1078-1089. Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Wrynla XH, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. PMID: 35879412; PMCID: PMC9355872.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    13. Flavivirus NS1 Triggers Tissue-Specific Disassembly of Intercellular Junctions Leading to Barrier Dysfunction and Vascular Leak in a GSK-3β-Dependent Manner. Pathogens. 2022 May 24; 11(6). Puerta-Guardo H, Biering SB, de Sousa FTG, Shu J, Glasner DR, Li J, Blanc SF, Beatty PR, Harris E. PMID: 35745469; PMCID: PMC9228372.
      View in: PubMed   Mentions: 19     Fields:    
    14. Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2. ACS Infect Dis. 2021 08 13; 7(8):2337-2351. Biering SB, Van Dis E, Wehri E, Yamashiro LH, Huu Wrynla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. PMID: 34129317.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCellsPHPublic Health
    15. Rapid, point-of-care molecular diagnostics with Cas13. medRxiv. 2021 Apr 05. Agrawal S, Fanton A, Chandrasekaran SS, Charrez B, Escajeda AM, Son S, Mcintosh R, Bhuiya A, de León Derby MD, Switz NA, Armstrong M, Harris AR, Prywes N, Lukarska M, Biering SB, Smock DCJ, Mok A, Knott GJ, Dang Q, Van Dis E, Dugan E, Kim S, Liu TY, IGI Testing Consortium, Harris E, Stanley SA, Lareau LF, Tan MX, Fletcher DA, Doudna JA, Savage DF, Hsu PD. PMID: 33354689; PMCID: PMC7755151.
      View in: PubMed   Mentions:
    16. Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation. PLoS Pathog. 2019 07; 15(7):e1007938. Wang C, Puerta-Guardo H, Biering SB, Glasner DR, Tran EB, Patana M, Gomberg TA, Malvar C, Lo NTN, Espinosa DA, Harris E. PMID: 31356638; PMCID: PMC6687192.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    17. Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism. Cell Rep. 2019 02 05; 26(6):1598-1613.e8. Puerta-Guardo H, Glasner DR, Espinosa DA, Biering SB, Patana M, Ratnasiri K, Wang C, Beatty PR, Harris E. PMID: 30726741; PMCID: PMC6934102.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    18. Corrigendum: Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol. 2019; 10:32. Lee JH, Park BS, Alam I, Han KR, Biering SB, Kim SJ, Choi J, Seok JH, Chung MS, Kim HM, Hwang S, Kim KH. PMID: 30766514; PMCID: PMC6365952.
      View in: PubMed   Mentions:
    19. Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens. Cell Host Microbe. 2018 11 14; 24(5):677-688.e5. Bouziat R, Biering SB, Kouame E, Sangani KA, Kang S, Ernest JD, Varma M, Brown JJ, Urbanek K, Dermody TS, Ng A, Hinterleitner R, Hwang S, Jabri B. PMID: 30392830; PMCID: PMC6326098.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    20. Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol. 2018; 9:1466. Lee JH, Park BS, Han KR, Biering SB, Kim SJ, Choi J, Seok JH, Alam I, Chung MS, Kim HM, Hwang S, Kim KH. PMID: 30038601; PMCID: PMC6046605.
      View in: PubMed   Mentions: 11  
    21. Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays. 2018 06; 40(6):e1700231. Brown HM, Biering SB, Zhu A, Choi J, Hwang S. PMID: 29603284; PMCID: PMC5986617.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. LC3s hire membrane breakers to attack viral shelters. Autophagy. 2017; 13(11):2010-2012. Biering SB, Choi J, Brown HM, Hwang S. PMID: 28949789; PMCID: PMC5788476.
      View in: PubMed   Mentions: 3     Fields:    
    23. Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. Cell Host Microbe. 2017 Jul 12; 22(1):74-85.e7. Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S. PMID: 28669671; PMCID: PMC5591033.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    24. Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy. Small GTPases. 2017 10 02; 8(4):199-207. Choi J, Biering SB, Hwang S. PMID: 27428166; PMCID: PMC5680725.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    25. Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Autophagy. 2016 07 02; 12(7):1153-67. Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S. PMID: 27172324; PMCID: PMC4990996.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    26. The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. Immunity. 2014 Jun 19; 40(6):924-35. Choi J, Park S, Biering SB, Selleck E, Liu CY, Zhang X, Fujita N, Saitoh T, Akira S, Yoshimori T, Sibley LD, Hwang S, Virgin HW. PMID: 24931121; PMCID: PMC4107903.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    27. Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced Nipah virus fusion and cell entry. PLoS Pathog. 2013; 9(11):e1003770. Liu Q, Stone JA, Bradel-Tretheway B, Dabundo J, Benavides Montano JA, Santos-Montanez J, Biering SB, Nicola AV, Iorio RM, Lu X, Aguilar HC. PMID: 24278018; PMCID: PMC3837712.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    28. Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion but do not block the interaction with the homologous F protein. J Virol. 2013 Mar; 87(6):3119-29. Zhu Q, Biering SB, Mirza AM, Grasseschi BA, Mahon PJ, Lee B, Aguilar HC, Iorio RM. PMID: 23283956; PMCID: PMC3592174.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    29. N-Glycans on the Nipah virus attachment glycoprotein modulate fusion and viral entry as they protect against antibody neutralization. J Virol. 2012 Nov; 86(22):11991-2002. Biering SB, Huang A, Vu AT, Robinson LR, Bradel-Tretheway B, Choi E, Lee B, Aguilar HC. PMID: 22915812; PMCID: PMC3486489.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    30. A comparative density functional study of the high-pressure phases of solid ZnX, CdX, and HgX (X = S, Se, and Te): trends and relativistic effects. J Chem Phys. 2012 Jul 21; 137(3):034705. Biering S, Schwerdtfeger P. PMID: 22830722.
      View in: PubMed   Mentions: 1     Fields:    
    31. A comparative density functional study of the low pressure phases of solid ZnX, CdX, and HgX: trends and relativistic effects. J Chem Phys. 2012 Jan 21; 136(3):034504. Biering S, Schwerdtfeger P. PMID: 22280764.
      View in: PubMed   Mentions: 1     Fields:    
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