Marianna Alperin

Title(s)Professor, Ob/Gyn & Reproductive sciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-6004-1803 Additional info
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    Collapse Biography 
    Collapse Education and Training
    St. Louis University, SOM, St. Louis, MOM.D.05/2002Medicine
    Brigham and Women's and MGH Hospitals, Harvard SOM, Boston, MA06/2005Obstetrics and Gynecology
    University of Pittsburgh, Pittsburgh, PAM.S.06/2007Research Design
    Magee Womens Hospital, University of Pittsburgh, Pittsburgh, PA06/2008Female Pelvic Medicine and Reconstructive Surgery

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Pathways underlying recovery of injured urethral sphincter and a novel regenerative biomaterial intervention
    NIH R01DK128639Jul 15, 2021 - Apr 30, 2025
    Role: Principal Investigator
    Prevention of pelvic floor muscle dysfunction with extracellular matrix hydrogel
    NIH R01HD102184Sep 30, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Injectable Tissue-Specific Extracellular Matrix Hydrogel for Pelvic Skeletal Muscle Regeneration Following Birth Injury
    NIH R21HD094566Dec 1, 2017 - Nov 30, 2020
    Role: Principal Investigator
    Mechanisms and impact of pregnancy-induced adaptations in pelvic floor muscles
    NIH R01HD092515Aug 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Impact of Aging on Structure and Function of Pelvic Floor Muscles
    NIH R03AG050951Aug 1, 2016 - Aug 31, 2019
    Role: Principal Investigator
    Architectural Design of the Pelvic Floor Skeletal Muscles
    NIH R03HD075994Jun 25, 2013 - May 31, 2016
    Role: Principal Investigator
    UC San Diego Womens Reproductive Health Research Program
    NIH K12HD001259Jul 23, 1999 - Jun 30, 2025
    Role: Scholar

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Proregenerative extracellular matrix hydrogel mitigates pathological alterations of pelvic skeletal muscles after birth injury. Sci Transl Med. 2023 08 02; 15(707):eabj3138. Duran P, Boscolo Sesillo F, Cook M, Burnett L, Menefee SA, Do E, French S, Zazueta-Damian G, Dzieciatkowska M, Saviola AJ, Shah MM, Sanvictores C, Osborn KG, Hansen KC, Shtrahman M, Christman KL, Alperin M. PMID: 37531414; PMCID: PMC10460616.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Impact of sex and aging on radiographic and functional parameters of the anal sphincter complex in patients with accidental bowel leakage. Neurourol Urodyn. 2023 04; 42(4):751-760. Artsen AM, Dyer KY, Routzong MR, Zazueta-Damian G, Weinstein MM, Alperin M. PMID: 36805621; PMCID: PMC10513003.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury. NPJ Regen Med. 2022 Dec 16; 7(1):72. Sesillo FB, Rajesh V, Wong M, Duran P, Rudell JB, Rundio CP, Baynes BB, Laurent LC, Sacco A, Christman KL, Alperin M. PMID: 36526635; PMCID: PMC9758192.
      View in: PubMed   Mentions: 1  
    4. Foundational science and mechanistic insights for a shared disease model: an expert consensus : Developed by the AUGS Basic Science Subcommittee and IUGA Special Interest Group. Int Urogynecol J. 2022 06; 33(6):1387-1392. Alperin M, Abramowitch S, Alarab M, Bortolini M, Brown B, Burnett LA, Connell KA, Damaser M, de Vita R, Gargett CE, Guess MK, Guler Z, Jorge RN, Kelley RS, Kibschull M, Miller K, Moalli PA, Mysorekar IU, Routzong MR, Shynlova O, Swenson CW, Therriault MA, Northington GM. PMID: 35674811; PMCID: PMC9266184.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Mechanisms governing protective pregnancy-induced adaptations of the pelvic floor muscles in the rat preclinical model. Am J Obstet Gynecol. 2022 05; 226(5):708.e1-708.e13. Rieger MM, Wong M, Burnett LA, Sesillo FB, Baynes BB, Alperin M. PMID: 34801444; PMCID: PMC9172206.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Quantifying the Effects of Aging on Morphological and Cellular Properties of Human Female Pelvic Floor Muscles. Ann Biomed Eng. 2021 Aug; 49(8):1836-1847. Rieger M, Duran P, Cook M, Schenk S, Shah M, Jacobs M, Christman K, Kado DM, Alperin M. PMID: 33683527; PMCID: PMC8376748.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. Deeper dive into tissue-level events that incite and promote pelvic organ prolapse. Am J Obstet Gynecol. 2021 01; 224(1):1-2. Alperin M. PMID: 33386102.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Isolation of muscle stem cells from rat skeletal muscles. Stem Cell Res. 2020 03; 43:101684. Boscolo Sesillo F, Wong M, Cortez A, Alperin M. PMID: 31931473; PMCID: PMC7357689.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Age-associated changes in the mechanical properties of human cadaveric pelvic floor muscles. J Biomech. 2020 01 02; 98:109436. Burnett LA, Cook M, Shah S, Michelle Wong M, Kado DM, Alperin M. PMID: 31708240; PMCID: PMC6956987.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Uncovering changes in proteomic signature of rat pelvic floor muscles in pregnancy. Am J Obstet Gynecol. 2019 08; 221(2):130.e1-130.e9. Burnett LA, Boscolo FS, Laurent LC, Wong M, Alperin M. PMID: 31047881; PMCID: PMC6667293.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    11. Mechanical impact of parturition-related strains on rat pelvic striated sphincters. Neurourol Urodyn. 2019 03; 38(3):912-919. Duran P, Ward S, Christman KL, Alperin M. PMID: 30779377; PMCID: PMC6431564.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy. J Anat. 2019 04; 234(4):543-550. Sheth VR, Duran P, Wong J, Shah S, Du J, Christman KL, Chang EY, Alperin M. PMID: 30740685; PMCID: PMC6422690.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. The mysteries of menopause and urogynecologic health: clinical and scientific gaps. Menopause. 2019 01; 26(1):103-111. Alperin M, Burnett L, Lukacz E, Brubaker L. PMID: 30300297; PMCID: PMC6376984.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    14. Recurrence of Rectal Prolapse After Surgical Repair in Women With Pelvic Organ Prolapse. Dis Colon Rectum. 2018 Jul; 61(7):861-867. Catanzarite T, Klaristenfeld DD, Tomassi MJ, Zazueta-Damian G, Alperin M. PMID: 29528907; PMCID: PMC5992067.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Pelvic muscles' mechanical response to strains in the absence and presence of pregnancy-induced adaptations in a rat model. Am J Obstet Gynecol. 2018 05; 218(5):512.e1-512.e9. Catanzarite T, Bremner S, Barlow CL, Bou-Malham L, O'Connor S, Alperin M. PMID: 29432755; PMCID: PMC5916022.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    16. The Role of the Surgeon on Outcomes of Vaginal Prolapse Surgery With Mesh. Female Pelvic Med Reconstr Surg. 2017 Sep/Oct; 23(5):293-296. Eilber KS, Alperin M, Khan A, Wu N, Pashos CL, Clemens JQ, Anger JT. PMID: 28134701; PMCID: PMC5612380.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Structure-function relationship of the human external anal sphincter. Int Urogynecol J. 2018 May; 29(5):673-678. Stewart AM, Cook MS, Dyer KY, Alperin M. PMID: 28689239; PMCID: PMC5889349.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Architectural assessment of rhesus macaque pelvic floor muscles: comparison for use as a human model. Int Urogynecol J. 2017 Oct; 28(10):1527-1535. Stewart AM, Cook MS, Esparza MC, Slayden OD, Alperin M. PMID: 28285397; PMCID: PMC5593758.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    19. Salpingo-oophorectomy at the Time of Benign Hysterectomy: A Systematic Review. Obstet Gynecol. 2016 Sep; 128(3):476-85. Evans EC, Matteson KA, Orejuela FJ, Alperin M, Balk EM, El-Nashar S, Gleason JL, Grimes C, Jeppson P, Mathews C, Wheeler TL, Murphy M, Society of Gynecologic Surgeons Systematic Review Group. PMID: 27500347; PMCID: PMC5100819.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    20. Impact of vaginal parity and aging on the architectural design of pelvic floor muscles. Am J Obstet Gynecol. 2016 09; 215(3):312.e1-9. Alperin M, Cook M, Tuttle LJ, Esparza MC, Lieber RL. PMID: 26953079; PMCID: PMC5003683.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    21. Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles. Am J Obstet Gynecol. 2016 08; 215(2):210.e1-7. Alperin M, Kaddis T, Pichika R, Esparza MC, Lieber RL. PMID: 26875952; PMCID: PMC5450638.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    22. Pregnancy-induced adaptations in the intrinsic structure of rat pelvic floor muscles. Am J Obstet Gynecol. 2015 Aug; 213(2):191.e1-7. Alperin M, Lawley DM, Esparza MC, Lieber RL. PMID: 25979618; PMCID: PMC4757427.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    23. Comparison of pelvic muscle architecture between humans and commonly used laboratory species. Int Urogynecol J. 2014 Nov; 25(11):1507-15. Alperin M, Tuttle LJ, Conner BR, Dixon DM, Mathewson MA, Ward SR, Lieber RL. PMID: 24915840; PMCID: PMC4264598.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    24. Collagen scaffold: a treatment for large mesh exposure following vaginal prolapse repair. Int Urogynecol J. 2014 Nov; 25(11):1597-9. Alperin M. PMID: 24832859; PMCID: PMC5450628.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Outcomes of vaginal prolapse surgery among female Medicare beneficiaries: the role of apical support. Obstet Gynecol. 2013 Nov; 122(5):981-987. Eilber KS, Alperin M, Khan A, Wu N, Pashos CL, Clemens JQ, Anger JT. PMID: 24104778; PMCID: PMC3857933.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    26. Architectural design of the pelvic floor is consistent with muscle functional subspecialization. Int Urogynecol J. 2014 Feb; 25(2):205-12. Tuttle LJ, Nguyen OT, Cook MS, Alperin M, Shah SB, Ward SR, Lieber RL. PMID: 23903821; PMCID: PMC4104205.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Patterns of pessary care and outcomes for medicare beneficiaries with pelvic organ prolapse. Female Pelvic Med Reconstr Surg. 2013 May-Jun; 19(3):142-7. Alperin M, Khan A, Dubina E, Tarnay C, Wu N, Pashos CL, Anger JT. PMID: 23611931; PMCID: PMC3635496.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. A randomized trial of prophylactic uterosacral ligament suspension at the time of hysterectomy for Prevention of Vaginal Vault Prolapse (PULS): design and methods. Contemp Clin Trials. 2013 Jul; 35(2):8-12. Alperin M, Weinstein M, Kivnick S, Duong TH, Menefee S. PMID: 23587538.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Two-year outcomes after vaginal prolapse reconstruction with mesh pelvic floor repair system. Female Pelvic Med Reconstr Surg. 2013 Mar-Apr; 19(2):72-8. Alperin M, Ellison R, Meyn L, Frankman E, Zyczynski HM. PMID: 23442503; PMCID: PMC4261688.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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