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Marianna Alperin

Title(s)Associate Professor, Reproductive Medicine
SchoolHealth Sciences
Phone858-534-5015
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    Collapse Biography 
    Collapse Education and Training
    St. Louis University, SOM, St. Louis, MOM.D.05/2002Medicine
    Brigham and Women's and MGH Hospitals, Harvard SOM, Boston, MA06/2005Obstetrics and Gynecology
    University of Pittsburgh, Pittsburgh, PAM.S.06/2007Research Design
    Magee Womens Hospital, University of Pittsburgh, Pittsburgh, PA06/2008Female Pelvic Medicine and Reconstructive Surgery

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Injectable Tissue-Specific Extracellular Matrix Hydrogel for Pelvic Skeletal Muscle Regeneration Following Birth Injury
    NIH/NICHD R21HD094566Dec 1, 2017 - Nov 30, 2019
    Role: Principal Investigator
    Mechanisms and impact of pregnancy-induced adaptations in pelvic floor muscles
    NIH/NICHD R01HD092515Aug 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Impact of Aging on Structure and Function of Pelvic Floor Muscles
    NIH/NIA R03AG050951Aug 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    Architectural Design of the Pelvic Floor Skeletal Muscles
    NIH/NICHD R03HD075994Jun 25, 2013 - May 31, 2015
    Role: Principal Investigator
    UC San Diego Womens Reproductive Health Research Program
    NIH/NICHD K12HD001259Jul 23, 1999 - Nov 30, 2004
    Role: Scholar

    Collapse ORNG Applications 
    Collapse Clinical Trials
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    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Boscolo Sesillo F, Wong M, Cortez A, Alperin M. Isolation of muscle stem cells from rat skeletal muscles. Stem Cell Res. 2020 03; 43:101684. PMID: 31931473.
      View in: PubMed
    2. Burnett LA, Cook M, Shah S, Michelle Wong M, Kado DM, Alperin M. Age-associated changes in the mechanical properties of human cadaveric pelvic floor muscles. J Biomech. 2020 Jan 02; 98:109436. PMID: 31708240.
      View in: PubMed
    3. Burnett LA, Boscolo FS, Laurent LC, Wong M, Alperin M. Uncovering changes in proteomic signature of rat pelvic floor muscles in pregnancy. Am J Obstet Gynecol. 2019 08; 221(2):130.e1-130.e9. PMID: 31047881.
      View in: PubMed
    4. Duran P, Ward S, Christman KL, Alperin M. Mechanical impact of parturition-related strains on rat pelvic striated sphincters. Neurourol Urodyn. 2019 03; 38(3):912-919. PMID: 30779377.
      View in: PubMed
    5. Sheth VR, Duran P, Wong J, Shah S, Du J, Christman KL, Chang EY, Alperin M. Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy. J Anat. 2019 Apr; 234(4):543-550. PMID: 30740685.
      View in: PubMed
    6. Alperin M, Burnett L, Lukacz E, Brubaker L. The mysteries of menopause and urogynecologic health: clinical and scientific gaps. Menopause. 2019 01; 26(1):103-111. PMID: 30300297.
      View in: PubMed
    7. Baah-Dwomoh A, Alperin M, Cook M, De Vita R. Mechanical Analysis of the Uterosacral Ligament: Swine vs. Human. Ann Biomed Eng. 2018 Dec; 46(12):2036-2047. PMID: 30051246.
      View in: PubMed
    8. Siddiqui NY, Gregory WT, Handa VL, DeLancey JOL, Richter HE, Moalli P, Barber MD, Pulliam S, Visco AG, Alperin M, Medina C, Fraser MO, Bradley CS. American Urogynecologic Society Prolapse Consensus Conference Summary Report. Female Pelvic Med Reconstr Surg. 2018 Jul/Aug; 24(4):260-263. PMID: 29309287.
      View in: PubMed
    9. Catanzarite T, Klaristenfeld DD, Tomassi MJ, Zazueta-Damian G, Alperin M. Recurrence of Rectal Prolapse After Surgical Repair in Women With Pelvic Organ Prolapse. Dis Colon Rectum. 2018 Jul; 61(7):861-867. PMID: 29528907.
      View in: PubMed
    10. Catanzarite T, Bremner S, Barlow CL, Bou-Malham L, O'Connor S, Alperin M. Pelvic muscles' mechanical response to strains in the absence and presence of pregnancy-induced adaptations in a rat model. Am J Obstet Gynecol. 2018 05; 218(5):512.e1-512.e9. PMID: 29432755.
      View in: PubMed
    11. Eilber KS, Alperin M, Khan A, Wu N, Pashos CL, Clemens JQ, Anger JT. The Role of the Surgeon on Outcomes of Vaginal Prolapse Surgery With Mesh. Female Pelvic Med Reconstr Surg. 2017 Sep/Oct; 23(5):293-296. PMID: 28134701.
      View in: PubMed
    12. Stewart AM, Cook MS, Dyer KY, Alperin M. Structure-function relationship of the human external anal sphincter. Int Urogynecol J. 2018 May; 29(5):673-678. PMID: 28689239.
      View in: PubMed
    13. Stewart AM, Cook MS, Esparza MC, Slayden OD, Alperin M. Architectural assessment of rhesus macaque pelvic floor muscles: comparison for use as a human model. Int Urogynecol J. 2017 Oct; 28(10):1527-1535. PMID: 28285397.
      View in: PubMed
    14. Cook MS, Bou-Malham L, Esparza MC, Alperin M. Age-related alterations in female obturator internus muscle. Int Urogynecol J. 2017 May; 28(5):729-734. PMID: 27704154.
      View in: PubMed
    15. Evans EC, Matteson KA, Orejuela FJ, Alperin M, Balk EM, El-Nashar S, Gleason JL, Grimes C, Jeppson P, Mathews C, Wheeler TL, Murphy M. Salpingo-oophorectomy at the Time of Benign Hysterectomy: A Systematic Review. Obstet Gynecol. 2016 Sep; 128(3):476-85. PMID: 27500347.
      View in: PubMed
    16. Alperin M, Cook M, Tuttle LJ, Esparza MC, Lieber RL. Impact of vaginal parity and aging on the architectural design of pelvic floor muscles. Am J Obstet Gynecol. 2016 09; 215(3):312.e1-9. PMID: 26953079.
      View in: PubMed
    17. Alperin M, Kaddis T, Pichika R, Esparza MC, Lieber RL. Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles. Am J Obstet Gynecol. 2016 08; 215(2):210.e1-7. PMID: 26875952.
      View in: PubMed
    18. Alperin M, Lawley DM, Esparza MC, Lieber RL. Pregnancy-induced adaptations in the intrinsic structure of rat pelvic floor muscles. Am J Obstet Gynecol. 2015 Aug; 213(2):191.e1-7. PMID: 25979618.
      View in: PubMed
    19. Batalden RP, Weinstein MM, Foust-Wright C, Alperin M, Wakamatsu MM, Pulliam SJ. Clinical application of IUGA/ICS classification system for mesh erosion. Neurourol Urodyn. 2016 06; 35(5):589-94. PMID: 25874639.
      View in: PubMed
    20. Alperin M, Tuttle LJ, Conner BR, Dixon DM, Mathewson MA, Ward SR, Lieber RL. Comparison of pelvic muscle architecture between humans and commonly used laboratory species. Int Urogynecol J. 2014 Nov; 25(11):1507-15. PMID: 24915840.
      View in: PubMed
    21. Alperin M. Collagen scaffold: a treatment for large mesh exposure following vaginal prolapse repair. Int Urogynecol J. 2014 Nov; 25(11):1597-9. PMID: 24832859.
      View in: PubMed
    22. Tuttle LJ, Alperin M, Lieber RL. Post-mortem timing of skeletal muscle biochemical and mechanical degradation. J Biomech. 2014 Apr 11; 47(6):1506-9. PMID: 24589021.
      View in: PubMed
    23. Eilber KS, Alperin M, Khan A, Wu N, Pashos CL, Clemens JQ, Anger JT. Outcomes of vaginal prolapse surgery among female Medicare beneficiaries: the role of apical support. Obstet Gynecol. 2013 Nov; 122(5):981-7. PMID: 24104778.
      View in: PubMed
    24. Frankman EA, Alperin M, Sutkin G, Meyn L, Zyczynski HM. Mesh exposure and associated risk factors in women undergoing transvaginal prolapse repair with mesh. Obstet Gynecol Int. 2013; 2013:926313. PMID: 24194763.
      View in: PubMed
    25. Tuttle LJ, Nguyen OT, Cook MS, Alperin M, Shah SB, Ward SR, Lieber RL. Architectural design of the pelvic floor is consistent with muscle functional subspecialization. Int Urogynecol J. 2014 Feb; 25(2):205-12. PMID: 23903821.
      View in: PubMed
    26. Clemons JL, Weinstein M, Guess MK, Alperin M, Moalli P, Gregory WT, Lukacz ES, Sung VW, Chen BH, Bradley CS. Impact of the 2011 FDA transvaginal mesh safety update on AUGS members' use of synthetic mesh and biologic grafts in pelvic reconstructive surgery. Female Pelvic Med Reconstr Surg. 2013 Jul-Aug; 19(4):191-8. PMID: 23797515.
      View in: PubMed
    27. Khan A, Alperin M, Wu N, Clemens JQ, Dubina E, Pashos CL, Anger JT. Comparative outcomes of open versus laparoscopic sacrocolpopexy among Medicare beneficiaries. Int Urogynecol J. 2013 Nov; 24(11):1883-91. PMID: 23652338.
      View in: PubMed
    28. Alperin M, Khan A, Dubina E, Tarnay C, Wu N, Pashos CL, Anger JT. Patterns of pessary care and outcomes for medicare beneficiaries with pelvic organ prolapse. Female Pelvic Med Reconstr Surg. 2013 May-Jun; 19(3):142-7. PMID: 23611931.
      View in: PubMed
    29. Alperin M, Weinstein M, Kivnick S, Duong TH, Menefee S. A randomized trial of prophylactic uterosacral ligament suspension at the time of hysterectomy for Prevention of Vaginal Vault Prolapse (PULS): design and methods. Contemp Clin Trials. 2013 Jul; 35(2):8-12. PMID: 23587538.
      View in: PubMed
    30. Alperin M, Ellison R, Meyn L, Frankman E, Zyczynski HM. Two-year outcomes after vaginal prolapse reconstruction with mesh pelvic floor repair system. Female Pelvic Med Reconstr Surg. 2013 Mar-Apr; 19(2):72-8. PMID: 23442503.
      View in: PubMed
    31. Alperin M, Kivnick S, Poon KY. Outpatient laparoscopic hysterectomy for large uteri. J Minim Invasive Gynecol. 2012 Nov-Dec; 19(6):689-94. PMID: 23084671.
      View in: PubMed
    32. Feola A, Moalli P, Alperin M, Duerr R, Gandley RE, Abramowitch S. Impact of pregnancy and vaginal delivery on the passive and active mechanics of the rat vagina. Ann Biomed Eng. 2011 Jan; 39(1):549-58. PMID: 20824342.
      View in: PubMed
    33. Shepherd JP, Alperin M, Meyn LA, Frankman EA, Zyczynski HM. Now or later...Does timing of a midurethral sling in relation to transvaginal prolapse repair affect continence outcomes at 1 year? Female Pelvic Med Reconstr Surg. 2010 Sep; 16(5):299-303. PMID: 22453509.
      View in: PubMed
    34. Alperin M, Feola A, Meyn L, Duerr R, Abramowitch S, Moalli P. Collagen scaffold: a treatment for simulated maternal birth injury in the rat model. Am J Obstet Gynecol. 2010 Jun; 202(6):589.e1-8. PMID: 20510960.
      View in: PubMed
    35. Alperin M, Feola A, Duerr R, Moalli P, Abramowitch S. Pregnancy- and delivery-induced biomechanical changes in rat vagina persist postpartum. Int Urogynecol J. 2010 Sep; 21(9):1169-74. PMID: 20424824.
      View in: PubMed
    36. Sutkin G, Alperin M, Meyn L, Wiesenfeld HC, Ellison R, Zyczynski HM. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010 Aug; 21(8):955-61. PMID: 20354678.
      View in: PubMed
    37. Alperin M, Sutkin G, Ellison R, Meyn L, Moalli P, Zyczynski H, Zyczynki H. Perioperative outcomes of the Prolift pelvic floor repair systems following introduction to a urogynecology teaching service. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Dec; 19(12):1617-22. PMID: 18712268.
      View in: PubMed
    38. Alperin M, Mantia-Smaldone G, Sagan ER. Conservative management of postoperatively diagnosed cystotomy. Urology. 2009 May; 73(5):1163.e17-9. PMID: 18514295.
      View in: PubMed
    39. Alperin M, Krohn MA, Parviainen K. Episiotomy and increase in the risk of obstetric laceration in a subsequent vaginal delivery. Obstet Gynecol. 2008 Jun; 111(6):1274-8. PMID: 18515508.
      View in: PubMed
    40. Alperin M, Debes K, Abramowitch S, Meyn L, Moalli PA. LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Jul; 19(7):977-86. PMID: 18265927.
      View in: PubMed
    41. Alperin M, Abrahams-Gessel S, Wakamatsu MM. Development of de novo urge incontinence in women post sling: the role of preoperative urodynamics in assessing the risk. Neurourol Urodyn. 2008; 27(5):407-11. PMID: 17985373.
      View in: PubMed
    42. Alperin M, Quaas A, Johnson NR, Hornstein MD. Endometrial ablation in a woman with a persistent uterine hemorrhage due to acute promyelocytic leukemia: a case report. J Reprod Med. 2007 Jun; 52(6):548-50. PMID: 17694980.
      View in: PubMed
    43. Alperin M, Moalli PA. Remodeling of vaginal connective tissue in patients with prolapse. Curr Opin Obstet Gynecol. 2006 Oct; 18(5):544-50. PMID: 16932050.
      View in: PubMed
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