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Gentry Patrick

TitleResearcher
InstitutionUniversity of California San Diego
DepartmentNeurobiology
Address9500 Gilman Drive #0366
La Jolla CA 92093
Phone858-534-4838
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    Collapse Research 
    Collapse Research Activities and Funding
    Ubiquitin-dependent Regulation of AMPA Receptor Trafficking and Turnover
    NIH/NINDS R01NS060847Sep 1, 2010 - May 31, 2015
    Role: Principal Investigator
    Regulatory mechanisms of proteasome function in neurons
    NIH/NINDS R21NS054732May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kyriakakis P, Catanho M, Hoffner N, Thavarajah W, Hu VJ, Chao SS, Hsu A, Pham V, Naghavian L, Dozier LE, Patrick GN, Coleman TP. Biosynthesis of Orthogonal Molecules Using Ferredoxin and Ferredoxin-NADP+ Reductase Systems Enables Genetically Encoded PhyB Optogenetics. ACS Synth Biol. 2018 02 16; 7(2):706-717. PMID: 29301067.
      View in: PubMed
    2. Gonzales FR, Howell KK, Dozier LE, Anagnostaras SG, Patrick GN. Proteasome phosphorylation regulates cocaine-induced sensitization. Mol Cell Neurosci. 2018 Apr; 88:62-69. PMID: 29217409.
      View in: PubMed
    3. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Dec 06; 25(12):2743-2752. PMID: 28958576.
      View in: PubMed
    4. Marquez-Lona EM, Torres-Machorro AL, Gonzales FR, Pillus L, Patrick GN. Phosphorylation of the 19S regulatory particle ATPase subunit, Rpt6, modifies susceptibility to proteotoxic stress and protein aggregation. PLoS One. 2017; 12(6):e0179893. PMID: 28662109.
      View in: PubMed
    5. Goo MS, Sancho L, Slepak N, Boassa D, Deerinck TJ, Ellisman MH, Bloodgood BL, Patrick GN. Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol. 2017 08 07; 216(8):2499-2513. PMID: 28630145.
      View in: PubMed
    6. Dwyer CA, Scudder SL, Lin Y, Dozier LE, Phan D, Allen NJ, Patrick GN, Esko JD. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. Sci Rep. 2017 Apr 18; 7:46576. PMID: 28418018.
      View in: PubMed
    7. Cifelli JL, Dozier L, Chung TS, Patrick GN, Yang J. Benzothiazole Amphiphiles Promote the Formation of Dendritic Spines in Primary Hippocampal Neurons. J Biol Chem. 2016 Jun 03; 291(23):11981-92. PMID: 27022020; PMCID: PMC4933251 [Available on 06/03/17].
      View in: PubMed, PubMed Central
    8. Rodrigues EM, Scudder SL, Goo MS, Patrick GN. Aß-Induced Synaptic Alterations Require the E3 Ubiquitin Ligase Nedd4-1. J Neurosci. 2016 Feb 03; 36(5):1590-5. PMID: 26843640; PMCID: PMC4737771.
      View in: PubMed, PubMed Central
    9. Goo MS, Scudder SL, Patrick GN. Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors. Front Mol Neurosci. 2015; 8:60. PMID: 26528125; PMCID: PMC4607782.
      View in: PubMed, PubMed Central
    10. Scudder SL, Patrick GN. Synaptic structure and function are altered by the neddylation inhibitor MLN4924. Mol Cell Neurosci. 2015 Mar; 65:52-7. PMID: 25701678; PMCID: PMC4844066.
      View in: PubMed, PubMed Central
    11. Scudder SL, Goo MS, Cartier AE, Molteni A, Schwarz LA, Wright R, Patrick GN. Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8. J Neurosci. 2014 Dec 10; 34(50):16637-49. PMID: 25505317; PMCID: PMC4261092.
      View in: PubMed, PubMed Central
    12. Hamilton AM, Oh WC, Vega-Ramirez H, Stein IS, Hell JW, Patrick GN, Zito K. Activity-dependent growth of new dendritic spines is regulated by the proteasome. Neuron. 2012 Jun 21; 74(6):1023-30. PMID: 22726833; PMCID: PMC3500563.
      View in: PubMed, PubMed Central
    13. Cartier AE, Ubhi K, Spencer B, Vazquez-Roque RA, Kosberg KA, Fourgeaud L, Kanayson P, Patrick C, Rockenstein E, Patrick GN, Masliah E. Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. PLoS One. 2012; 7(4):e34713. PMID: 22514658; PMCID: PMC3326048.
      View in: PubMed, PubMed Central
    14. Djakovic SN, Marquez-Lona EM, Jakawich SK, Wright R, Chu C, Sutton MA, Patrick GN. Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons. J Neurosci. 2012 Apr 11; 32(15):5126-31. PMID: 22496558; PMCID: PMC3348785.
      View in: PubMed, PubMed Central
    15. Schwarz LA, Patrick GN. Ubiquitin-dependent endocytosis, trafficking and turnover of neuronal membrane proteins. Mol Cell Neurosci. 2012 Mar; 49(3):387-93. PMID: 21884797; PMCID: PMC3279607.
      View in: PubMed, PubMed Central
    16. Schwarz LA, Hall BJ, Patrick GN. Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway. J Neurosci. 2010 Dec 08; 30(49):16718-29. PMID: 21148011; PMCID: PMC3079366.
      View in: PubMed, PubMed Central
    17. Keil JM, Shen Z, Briggs SP, Patrick GN. Regulation of STIM1 and SOCE by the ubiquitin-proteasome system (UPS). PLoS One. 2010 Oct 18; 5(10):e13465. PMID: 20976103; PMCID: PMC2956693.
      View in: PubMed, PubMed Central
    18. Djakovic SN, Schwarz LA, Barylko B, DeMartino GN, Patrick GN. Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II. J Biol Chem. 2009 Sep 25; 284(39):26655-65. PMID: 19638347; PMCID: PMC2785353.
      View in: PubMed, PubMed Central
    19. Cartier AE, Djakovic SN, Salehi A, Wilson SM, Masliah E, Patrick GN. Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci. 2009 Jun 17; 29(24):7857-68. PMID: 19535597; PMCID: PMC2748938.
      View in: PubMed, PubMed Central
    20. Kerjan G, Koizumi H, Han EB, Dubé CM, Djakovic SN, Patrick GN, Baram TZ, Heinemann SF, Gleeson JG. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6766-71. PMID: 19342486; PMCID: PMC2672532.
      View in: PubMed, PubMed Central
    21. Patrick GN. Synapse formation and plasticity: recent insights from the perspective of the ubiquitin proteasome system. Curr Opin Neurobiol. 2006 Feb; 16(1):90-4. PMID: 16427269.
      View in: PubMed
    22. Patrick GN, Bingol B, Weld HA, Schuman EM. Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs. Curr Biol. 2003 Dec 02; 13(23):2073-81. PMID: 14653997.
      View in: PubMed
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