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Mark Ginsberg

Title(s)Distinguished Professor, Medicine
SchoolHealth Sciences
Phone858-822-6432
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    Collapse Overview 
    Collapse Overview
    Dr. Mark H. Ginsberg is a professor of medicine and director of the Physician-Scientist Training Pathway at UC San Diego. Dr. Ginsberg moved his research laboratory from the Scripps Research Institute to the Department of Medicine at the University of California, San Diego in July 2004.

    Research Interests
    Molecular structure and function of integrins in immune responses.

    Education and Training
    Psychology - McGill University, Montreal, Canada - 1965
    MD (Summa cum laude) - State University of NY - 1970
    Intern/Resident - University of Chicago - 1970-1973
    Rheumatology Fellow - University of Chicago - 1973-1975

    Collapse Research 
    Collapse Research Activities and Funding
    Deconvoluting the Vascular Adhesome
    NIH/NHLBI R35HL139947Jan 1, 2018 - Dec 31, 2024
    Role: Principal Investigator
    Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis
    NIH P01NS092521Sep 1, 2015 - Jun 30, 2020
    Role: Co-Investigator
    Tilting the Balance of Integrin Activation
    NIH/NHLBI R01HL126844Apr 2, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Composition and Functions of the Integrin Activation Complex
    NIH/NHLBI R01HL117807May 1, 2014 - Apr 30, 2018
    Role: Principal Investigator
    KRIT1 and Vascular Integrity
    NIH/NHLBI R01HL106489Jan 3, 2011 - Dec 31, 2020
    Role: Principal Investigator
    Assembly, dynamics and evolution of cell-cell and cell-matrix adhesions
    NIH U01GM094663Sep 30, 2010 - Jun 30, 2015
    Role: Co-Investigator
    Assay Development for HT Molecular Screening for Inhibitors of Integrin Signaling
    NIH/NINDS R21NS059433Sep 30, 2007 - Aug 31, 2008
    Role: Principal Investigator
    alpha4beta1 Intergrin Signaling In Immunity And Arthritis
    NIH/NIAMS R01AR052367Jul 1, 2007 - May 31, 2012
    Role: Principal Investigator
    Blood Cells in Hemostasis and Thrombosis
    NIH/NHLBI T32HL086344Jan 1, 2007 - May 30, 2024
    Role: Principal Investigator
    Regulation of Fibronectin Matrix Assembly
    NIH/NHLBI R01HL080529Apr 1, 2005 - Aug 31, 2005
    Role: Principal Investigator
    Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
    NIH/NHLBI P01HL078784Dec 1, 2004 - Apr 30, 2020
    Role: Principal Investigator
    A Proteomics Research Resource for Integrative Biology
    NIH P41RR018522Sep 15, 2003 - Jun 30, 2013
    Role: Co-Investigator
    Cytoplasmic Regulation of a4b1 Avidity under Flow
    NIH/FIC R03TW006425Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator
    Cell Migration Consortium
    NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
    Role: Co-Investigator
    Integrin Signaling in Hemostasis and Blood Diseases
    NIH/NHLBI P01HL057900Apr 1, 1997 - Jan 31, 2014
    Role: Co-Investigator
    GORDON CONFERENCE--FIBRONECTIN AND MACROMOLECULES
    NIH/NHLBI R13HL049091Feb 1, 1993 - Jan 31, 1994
    Role: Principal Investigator
    CELL ADHESION MECHANISMS IN VASCULAR DISEASE
    NIH/NHLBI P01HL048728Sep 30, 1992 - Aug 31, 2004
    Role: Principal Investigator
    VASCULAR BIOLOGY, THROMBOSIS, AND HEMOSTASIS
    NIH/NHLBI T32HL007695Jul 1, 1991 - Jun 30, 2007
    Role: Principal Investigator
    Thrombus Formation and Antithrombotic Intervention
    NIH/NHLBI P01HL031950Apr 1, 1984 - Jun 30, 2016
    Role: Co-Investigator
    FIBRONECTIN AND PLATELETS
    NIH/NHLBI R01HL028235Jan 1, 1982 - Jun 30, 1996
    Role: Principal Investigator
    Regulation of Integrin Alpha4 Betal
    NIH/NIAMS R01AR027214Aug 1, 1980 - Nov 30, 2011
    Role: Principal Investigator
    PLATELETS IN RHEUMATIC DISEASE
    NIH/NIAMS R37AR027214Aug 1, 1980 - Jan 31, 2001
    Role: Principal Investigator
    GENERAL CLINICAL RESEARCH CENTER
    NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sun H, Kuk W, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg MH. ß7 Integrin Inhibition Can Increase Intestinal Inflammation By Impairing Homing of CD25hiFoxP3+ Regulatory T Cells. Cell Mol Gastroenterol Hepatol. 2019 Nov 07. PMID: 31707128.
      View in: PubMed
    2. Sun H, Fan Z, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. Frontline Science: A flexible kink in the transmembrane domain impairs ß2 integrin extension and cell arrest from rolling. J Leukoc Biol. 2019 Sep 01. PMID: 31475386.
      View in: PubMed
    3. Koskimäki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Carrión-Penagos J, Lyne SB, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IA. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 Aug 19; 7(1):132. PMID: 31426861.
      View in: PubMed
    4. Lyne SB, Girard R, Koskimäki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrión-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA. Biomarkers of cavernous angioma with symptomatic hemorrhage. JCI Insight. 2019 Jun 20; 4(12). PMID: 31217347.
      View in: PubMed
    5. Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH. Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. J Cell Biol. 2019 Jun 03; 218(6):1799-1809. PMID: 30988001.
      View in: PubMed
    6. Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IA. Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes. JCI Insight. 2019 Feb 07; 4(3). PMID: 30728328.
      View in: PubMed
    7. Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, Arnaout MA, Gutierrez E, Groisman A, Ginsberg MH, Ley K. High-Affinity Bent ß2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis. Cell Rep. 2019 01 02; 26(1):119-130.e5. PMID: 30605669.
      View in: PubMed
    8. Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood. 2019 01 17; 133(3):193-204. PMID: 30442679.
      View in: PubMed
    9. Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv. 2018 09 25; 2(18):2358-2368. PMID: 30242097.
      View in: PubMed
    10. Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Koskimäki J, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330. PMID: 29946133.
      View in: PubMed
    11. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol. 2018 06 15; 200(12):4012-4023. PMID: 29703862.
      View in: PubMed
    12. Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH. Transmission of integrin ß7 transmembrane domain topology enables gut lymphoid tissue development. J Cell Biol. 2018 04 02; 217(4):1453-1465. PMID: 29535192.
      View in: PubMed
    13. Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D. The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human aVß3 Integrin via Steric Hindrance. Structure. 2017 11 07; 25(11):1732-1739.e5. PMID: 29033288.
      View in: PubMed
    14. Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346. PMID: 28970240.
      View in: PubMed
    15. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017 06 15; 198(12):4639-4651. PMID: 28515282.
      View in: PubMed
    16. Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arterioscler Thromb Vasc Biol. 2017 07; 37(7):1323-1331. PMID: 28495929.
      View in: PubMed
    17. Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH, Kim C. Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. J Biol Chem. 2017 06 16; 292(24):9858-9864. PMID: 28487468.
      View in: PubMed
    18. Lagarrigue F, Gertler FB, Ginsberg MH, Cantor JM. Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. J Immunol. 2017 05 01; 198(9):3410-3415. PMID: 28348273.
      View in: PubMed
    19. Baumer Y, McCurdy S, Alcala M, Mehta N, Lee BH, Ginsberg MH, Boisvert WA. CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis. Atherosclerosis. 2017 01; 256:105-114. PMID: 28012647.
      View in: PubMed
    20. Gingras AR, Puzon-McLaughlin W, Bobkov AA, Ginsberg MH. Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins. Structure. 2016 12 06; 24(12):2152-2162. PMID: 27839947.
      View in: PubMed
    21. Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14; 30(5):792-805. PMID: 27908736.
      View in: PubMed
    22. Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg M, Groisman A, Ley K. Neutrophil recruitment limited by high-affinity bent ß2 integrin binding ligand in cis. Nat Commun. 2016 08 31; 7:12658. PMID: 27578049.
      View in: PubMed
    23. Abplanalp WT, Conklin DJ, Cantor JM, Ginsberg MH, Wysoczynski M, Bhatnagar A, O'Toole TE. Enhanced Integrin a4ß1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Diabetes. 2016 Nov; 65(11):3505-3515. PMID: 27495221.
      View in: PubMed
    24. Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer TS. A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 08 19; 291(34):17536-46. PMID: 27365391.
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    25. Lagarrigue F, Kim C, Ginsberg MH. The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood. 2016 07 28; 128(4):479-87. PMID: 27207789.
      View in: PubMed
    26. de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg MH, Palacín M, Féral CC. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. J Biol Chem. 2016 Apr 29; 291(18):9700-11. PMID: 26945935.
      View in: PubMed
    27. de Kreuk BJ, Gingras AR, Knight JD, Liu JJ, Gingras AC, Ginsberg MH. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. Elife. 2016 Jan 19; 5:e11394. PMID: 26780829.
      View in: PubMed
    28. Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH. Ubiquitylation of CD98 limits cell proliferation and clonal expansion. J Cell Sci. 2015 Dec 01; 128(23):4273-8. PMID: 26493331.
      View in: PubMed
    29. Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, Goldfinger LE. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochem Biophys Res Commun. 2015 Nov 27; 467(4):785-91. PMID: 26498519.
      View in: PubMed
    30. Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg MH. A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Nat Commun. 2015 Sep 30; 6:8492. PMID: 26419705.
      View in: PubMed
    31. Dai A, Ye F, Taylor DW, Hu G, Ginsberg MH, Taylor KA. The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand. J Biol Chem. 2015 Nov 06; 290(45):27168-75. PMID: 26391523.
      View in: PubMed
    32. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-1572. PMID: 26278174.
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    33. Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg MH, McEver RP. Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med. 2015 Jul 27; 212(8):1267-81. PMID: 26169939.
      View in: PubMed
    34. Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg MH, Ruggeri ZM, Ruf W. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. J Clin Invest. 2015 Apr; 125(4):1471-84. PMID: 25705884.
      View in: PubMed
    35. Schmidt T, Suk JE, Ye F, Situ AJ, Mazumder P, Ginsberg MH, Ulmer TS. Annular anionic lipids stabilize the integrin aIIbß3 transmembrane complex. J Biol Chem. 2015 Mar 27; 290(13):8283-93. PMID: 25632962.
      View in: PubMed
    36. Cantor JM, Rose DM, Slepak M, Ginsberg MH. Fine-tuning Tumor Immunity with Integrin Trans-regulation. Cancer Immunol Res. 2015 Jun; 3(6):661-7. PMID: 25600437.
      View in: PubMed
    37. Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J, Ginsberg MH, H van der Horst E. Antitumor activity of an anti-CD98 antibody. Int J Cancer. 2015 Aug 01; 137(3):710-20. PMID: 25556716.
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    38. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. PMID: 25587038.
      View in: PubMed
    39. Ginsberg MH. Integrin activation. BMB Rep. 2014 Dec; 47(12):655-9. PMID: 25388208.
      View in: PubMed
    40. Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C, Ginsberg MH, Féral CC. CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Res. 2014 Dec 01; 74(23):6878-89. PMID: 25267066.
      View in: PubMed
    41. Ye F, Lagarrigue F, Ginsberg MH. SnapShot: talin and the modular nature of the integrin adhesome. Cell. 2014 Mar 13; 156(6):1340-1340.e1. PMID: 24630731.
      View in: PubMed
    42. Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ. ADAP interactions with talin and kindlin promote platelet integrin aIIbß3 activation and stable fibrinogen binding. Blood. 2014 May 15; 123(20):3156-65. PMID: 24523237.
      View in: PubMed
    43. Ye F, Snider AK, Ginsberg MH. Talin and kindlin: the one-two punch in integrin activation. Front Med. 2014 Mar; 8(1):6-16. PMID: 24477625.
      View in: PubMed
    44. Spiegler S, Najm J, Liu J, Gkalympoudis S, Schröder W, Borck G, Brockmann K, Elbracht M, Fauth C, Ferbert A, Freudenberg L, Grasshoff U, Hellenbroich Y, Henn W, Hoffjan S, Hüning I, Korenke GC, Kroisel PM, Kunstmann E, Mair M, Munk-Schulenburg S, Nikoubashman O, Pauli S, Rudnik-Schöneborn S, Sudholt I, Sure U, Tinschert S, Wiednig M, Zoll B, Ginsberg MH, Felbor U. High mutation detection rates in cerebral cavernous malformation upon stringent inclusion criteria: one-third of probands are minors. Mol Genet Genomic Med. 2014 Mar; 2(2):176-85. PMID: 24689081.
      View in: PubMed
    45. Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH. The mechanism of kindlin-mediated activation of integrin aIIbß3. Curr Biol. 2013 Nov 18; 23(22):2288-2295. PMID: 24210614.
      View in: PubMed
    46. Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg MH. The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open. 2013; 2(10):1007-12. PMID: 24167710.
      View in: PubMed
    47. Gingras AR, Puzon-McLaughlin W, Ginsberg MH. The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail. J Biol Chem. 2013 Aug 16; 288(33):23639-49. PMID: 23814056.
      View in: PubMed
    48. Lee HS, Anekal P, Lim CJ, Liu CC, Ginsberg MH. Two modes of integrin activation form a binary molecular switch in adhesion maturation. Mol Biol Cell. 2013 May; 24(9):1354-62. PMID: 23468527.
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    49. Gingras AR, Ye F, Ginsberg MH. Reconstructing integrin activation in vitro. Methods Mol Biol. 2013; 1046:1-17. PMID: 23868579.
      View in: PubMed
    50. Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg MH, Teitelbaum SL. Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol. 2013 Feb; 33(4):830-44. PMID: 23230271.
      View in: PubMed
    51. Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol. 2012 Oct 15; 199(2):331-45. PMID: 23071154.
      View in: PubMed
    52. Gingras AR, Liu JJ, Ginsberg MH. Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. J Cell Biol. 2012 Oct 01; 199(1):39-48. PMID: 23007647.
      View in: PubMed
    53. Kim C, Ye F, Hu X, Ginsberg MH. Talin activates integrins by altering the topology of the ß transmembrane domain. J Cell Biol. 2012 May 28; 197(5):605-11. PMID: 22641344.
      View in: PubMed
    54. Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to aIIbß3. PLoS One. 2012; 7(3):e34056. PMID: 22457811.
      View in: PubMed
    55. Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg MH, Fässler R, Ley K. Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood. 2012 May 03; 119(18):4275-82. PMID: 22431571.
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    56. Cantor JM, Ginsberg MH. CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci. 2012 Mar 15; 125(Pt 6):1373-82. PMID: 22499670.
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    57. Banno A, Goult BT, Lee H, Bate N, Critchley DR, Ginsberg MH. Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem. 2012 Apr 20; 287(17):13799-812. PMID: 22351767.
      View in: PubMed
    58. Kim C, Schmidt T, Cho EG, Ye F, Ulmer TS, Ginsberg MH. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature. 2011 Dec 18; 481(7380):209-13. PMID: 22178926.
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    59. Kim J, Sherman NE, Fox JW, Ginsberg MH. Phosphorylation sites in the cerebral cavernous malformations complex. J Cell Sci. 2011 Dec 01; 124(Pt 23):3929-32. PMID: 22194303.
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    60. McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke. 2012 Feb; 43(2):571-4. PMID: 22034008.
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    61. Gutierrez E, Tkachenko E, Besser A, Sundd P, Ley K, Danuser G, Ginsberg MH, Groisman A. High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One. 2011; 6(9):e23807. PMID: 21961031.
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    62. Ye F, Kim C, Ginsberg MH. Reconstruction of integrin activation. Blood. 2012 Jan 05; 119(1):26-33. PMID: 21921044.
      View in: PubMed
    63. Sundd P, Gutierrez E, Petrich BG, Ginsberg MH, Groisman A, Ley K. Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation. 2011 Jul; 18(5):361-72. PMID: 21418380.
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    64. Ye F, Kim C, Ginsberg MH. Molecular mechanism of inside-out integrin regulation. J Thromb Haemost. 2011 Jul; 9 Suppl 1:20-25. PMID: 21781238.
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    65. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. PMID: 21665146.
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    66. Cantor J, Slepak M, Ege N, Chang JT, Ginsberg MH. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol. 2011 Jul 15; 187(2):851-60. PMID: 21670318.
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    67. Kim C, Ye F, Ginsberg MH. Regulation of integrin activation. Annu Rev Cell Dev Biol. 2011; 27:321-45. PMID: 21663444.
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    68. Liu JJ, Stockton RA, Gingras AR, Ablooglu AJ, Han J, Bobkov AA, Ginsberg MH. A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell. 2011 Jul 15; 22(14):2509-19. PMID: 21633110.
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    69. Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol. 2011 Jun; 13(6):660-7. PMID: 21572420.
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    70. Ring C, Ginsberg MH, Haling J, Pendergast AM. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):149-54. PMID: 21173240.
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    71. Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA, Critchley DR. Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol. 2011 Jan 15; 349(2):494-502. PMID: 21081121.
      View in: PubMed
    72. McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet. 2011 Jan 15; 20(2):211-22. PMID: 20940147.
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