Mark Ginsberg

TitleDistinguished Professor
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0726
La Jolla CA 92093
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    Collapse Overview
    Dr. Mark H. Ginsberg is a professor of medicine and director of the Physician-Scientist Training Pathway at UC San Diego. Dr. Ginsberg moved his research laboratory from the Scripps Research Institute to the Department of Medicine at the University of California, San Diego in July 2004.

    Research Interests
    Molecular structure and function of integrins in immune responses.

    Education and Training
    Psychology - McGill University, Montreal, Canada - 1965
    MD (Summa cum laude) - State University of NY - 1970
    Intern/Resident - University of Chicago - 1970-1973
    Rheumatology Fellow - University of Chicago - 1973-1975

    Collapse Research 
    Collapse Research Activities and Funding
    Deconvoluting the Vascular Adhesome
    NIH/NHLBI R35HL139947Jan 1, 2018 - Dec 31, 2024
    Role: Principal Investigator
    Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis
    NIH P01NS092521Sep 1, 2015 - Jun 30, 2020
    Role: Co-Investigator
    Tilting the Balance of Integrin Activation
    NIH/NHLBI R01HL126844Apr 2, 2015 - Mar 31, 2019
    Role: Principal Investigator
    Composition and Functions of the Integrin Activation Complex
    NIH/NHLBI R01HL117807May 1, 2014 - Apr 30, 2018
    Role: Principal Investigator
    KRIT1 and Vascular Integrity
    NIH/NHLBI R01HL106489Jan 3, 2011 - Dec 31, 2020
    Role: Principal Investigator
    Assembly, dynamics and evolution of cell-cell and cell-matrix adhesions
    NIH U01GM094663Sep 30, 2010 - Jun 30, 2015
    Role: Co-Investigator
    Assay Development for HT Molecular Screening for Inhibitors of Integrin Signaling
    NIH/NINDS R21NS059433Sep 30, 2007 - Aug 31, 2008
    Role: Principal Investigator
    alpha4beta1 Intergrin Signaling In Immunity And Arthritis
    NIH/NIAMS R01AR052367Jul 1, 2007 - May 31, 2012
    Role: Principal Investigator
    Blood Cells in Hemostasis and Thrombosis
    NIH/NHLBI T32HL086344Jan 1, 2007 - Apr 30, 2019
    Role: Principal Investigator
    Regulation of Fibronectin Matrix Assembly
    NIH/NHLBI R01HL080529Apr 1, 2005 - Aug 31, 2005
    Role: Principal Investigator
    Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
    NIH/NHLBI P01HL078784Dec 1, 2004 - Apr 30, 2020
    Role: Principal Investigator
    A Proteomics Research Resource for Integrative Biology
    NIH P41RR018522Sep 15, 2003 - Jun 30, 2013
    Role: Co-Investigator
    Cytoplasmic Regulation of a4b1 Avidity under Flow
    NIH/FIC R03TW006425Jul 1, 2003 - Jun 30, 2007
    Role: Principal Investigator
    Cell Migration Consortium
    NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
    Role: Co-Investigator
    Integrin Signaling in Hemostasis and Blood Diseases
    NIH/NHLBI P01HL057900Apr 1, 1997 - Jan 31, 2014
    Role: Co-Investigator
    NIH/NHLBI R13HL049091Feb 1, 1993 - Jan 31, 1994
    Role: Principal Investigator
    NIH/NHLBI P01HL048728Sep 30, 1992 - Aug 31, 2004
    Role: Principal Investigator
    NIH/NHLBI T32HL007695Jul 1, 1991 - Jun 30, 2007
    Role: Principal Investigator
    Thrombus Formation and Antithrombotic Intervention
    NIH/NHLBI P01HL031950Apr 1, 1984 - Jun 30, 2016
    Role: Co-Investigator
    NIH/NHLBI R01HL028235Jan 1, 1982 - Jun 30, 1996
    Role: Principal Investigator
    Regulation of Integrin Alpha4 Betal
    NIH/NIAMS R01AR027214Aug 1, 1980 - Nov 30, 2011
    Role: Principal Investigator
    NIH/NIAMS R37AR027214Aug 1, 1980 - Jan 31, 2001
    Role: Principal Investigator
    NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
    Role: Co-Investigator

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    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg M, Petrich BG, Chang JT. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol. 2018 Apr 27. PMID: 29703862.
      View in: PubMed
    2. Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg M. Transmission of integrin ß7 transmembrane domain topology enables gut lymphoid tissue development. J Cell Biol. 2018 Apr 02; 217(4):1453-1465. PMID: 29535192.
      View in: PubMed
    3. Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D. The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human aVß3 Integrin via Steric Hindrance. Structure. 2017 Nov 07; 25(11):1732-1739.e5. PMID: 29033288.
      View in: PubMed
    4. Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg M. Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations. J Exp Med. 2017 Nov 06; 214(11):3331-3346. PMID: 28970240.
      View in: PubMed
    5. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg M, Petrich BG, Chang JT. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017 06 15; 198(12):4639-4651. PMID: 28515282.
      View in: PubMed
    6. Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg M, Ruggeri ZM, Ruf W. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arterioscler Thromb Vasc Biol. 2017 Jul; 37(7):1323-1331. PMID: 28495929.
      View in: PubMed
    7. Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg M, Kim C. Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. J Biol Chem. 2017 06 16; 292(24):9858-9864. PMID: 28487468.
      View in: PubMed
    8. Lagarrigue F, Gertler FB, Ginsberg M, Cantor JM. Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. J Immunol. 2017 05 01; 198(9):3410-3415. PMID: 28348273.
      View in: PubMed
    9. Baumer Y, McCurdy S, Alcala M, Mehta N, Lee BH, Ginsberg M, Boisvert WA. CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis. Atherosclerosis. 2017 Jan; 256:105-114. PMID: 28012647.
      View in: PubMed
    10. Gingras AR, Puzon-McLaughlin W, Bobkov AA, Ginsberg M. Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins. Structure. 2016 12 06; 24(12):2152-2162. PMID: 27839947.
      View in: PubMed
    11. Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg M, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14; 30(5):792-805. PMID: 27908736.
      View in: PubMed
    12. Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg M, Groisman A, Ley K. Neutrophil recruitment limited by high-affinity bent ß2 integrin binding ligand in cis. Nat Commun. 2016 Aug 31; 7:12658. PMID: 27578049.
      View in: PubMed
    13. Abplanalp WT, Conklin DJ, Cantor JM, Ginsberg M, Wysoczynski M, Bhatnagar A, O'Toole TE. Enhanced Integrin a4ß1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Diabetes. 2016 Nov; 65(11):3505-3515. PMID: 27495221.
      View in: PubMed
    14. Schmidt T, Ye F, Situ AJ, An W, Ginsberg M, Ulmer TS. A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 08 19; 291(34):17536-46. PMID: 27365391; PMCID: PMC5016151 [Available on 08/19/17].
    15. Lagarrigue F, Kim C, Ginsberg M. The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood. 2016 07 28; 128(4):479-87. PMID: 27207789; PMCID: PMC4965904 [Available on 07/28/17].
    16. de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg M, Palacín M, Féral CC. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. J Biol Chem. 2016 Apr 29; 291(18):9700-11. PMID: 26945935; PMCID: PMC4850307 [Available on 04/29/17].
    17. de Kreuk BJ, Gingras AR, Knight JD, Liu JJ, Gingras AC, Ginsberg M. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. Elife. 2016 Jan 19; 5:e11394. PMID: 26780829; PMCID: PMC4733052.
    18. Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg M. Ubiquitylation of CD98 limits cell proliferation and clonal expansion. J Cell Sci. 2015 Dec 01; 128(23):4273-8. PMID: 26493331; PMCID: PMC4712820 [Available on 12/01/16].
    19. Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg M, Goldfinger LE. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochem Biophys Res Commun. 2015 Nov 27; 467(4):785-91. PMID: 26498519; PMCID: PMC4644438 [Available on 11/27/16].
    20. Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg M. A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Nat Commun. 2015 Sep 30; 6:8492. PMID: 26419705; PMCID: PMC4589889.
    21. Dai A, Ye F, Taylor DW, Hu G, Ginsberg M, Taylor KA. The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand. J Biol Chem. 2015 Nov 06; 290(45):27168-75. PMID: 26391523; PMCID: PMC4646401 [Available on 11/06/16].
    22. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg M, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-1572. PMID: 26278174.
      View in: PubMed
    23. Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg M, McEver RP. Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med. 2015 Jul 27; 212(8):1267-81. PMID: 26169939; PMCID: PMC4516797.
    24. Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg M, Ruggeri ZM, Ruf W. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. J Clin Invest. 2015 Apr; 125(4):1471-84. PMID: 25705884.
      View in: PubMed
    25. Schmidt T, Suk JE, Ye F, Situ AJ, Mazumder P, Ginsberg M, Ulmer TS. Annular anionic lipids stabilize the integrin aIIbß3 transmembrane complex. J Biol Chem. 2015 Mar 27; 290(13):8283-93. PMID: 25632962; PMCID: PMC4375483.
    26. Cantor JM, Rose DM, Slepak M, Ginsberg M. Fine-tuning Tumor Immunity with Integrin Trans-regulation. Cancer Immunol Res. 2015 Jun; 3(6):661-7. PMID: 25600437.
      View in: PubMed
    27. Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J, Ginsberg M, H van der Horst E. Antitumor activity of an anti-CD98 antibody. Int J Cancer. 2015 Aug 01; 137(3):710-20. PMID: 25556716.
      View in: PubMed
    28. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg M, Shattil SJ. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. PMID: 25587038; PMCID: PMC4366628.
    29. Ginsberg M. Integrin activation. BMB Rep. 2014 Dec; 47(12):655-9. PMID: 25388208; PMCID: PMC4345508.
    30. Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C, Ginsberg M, Féral CC. CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Res. 2014 Dec 01; 74(23):6878-89. PMID: 25267066.
      View in: PubMed
    31. Ye F, Lagarrigue F, Ginsberg M. SnapShot: talin and the modular nature of the integrin adhesome. Cell. 2014 Mar 13; 156(6):1340-1340.e1. PMID: 24630731; PMCID: PMC4479492.
    32. Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg M, Shattil SJ. ADAP interactions with talin and kindlin promote platelet integrin aIIbß3 activation and stable fibrinogen binding. Blood. 2014 May 15; 123(20):3156-65. PMID: 24523237.
      View in: PubMed
    33. Ye F, Snider AK, Ginsberg M. Talin and kindlin: the one-two punch in integrin activation. Front Med. 2014 Mar; 8(1):6-16. PMID: 24477625.
      View in: PubMed
    34. Spiegler S, Najm J, Liu J, Gkalympoudis S, Schröder W, Borck G, Brockmann K, Elbracht M, Fauth C, Ferbert A, Freudenberg L, Grasshoff U, Hellenbroich Y, Henn W, Hoffjan S, Hüning I, Korenke GC, Kroisel PM, Kunstmann E, Mair M, Munk-Schulenburg S, Nikoubashman O, Pauli S, Rudnik-Schöneborn S, Sudholt I, Sure U, Tinschert S, Wiednig M, Zoll B, Ginsberg M, Felbor U. High mutation detection rates in cerebral cavernous malformation upon stringent inclusion criteria: one-third of probands are minors. Mol Genet Genomic Med. 2014 Mar; 2(2):176-85. PMID: 24689081; PMCID: PMC3960060.
    35. Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg M. The mechanism of kindlin-mediated activation of integrin aIIbß3. Curr Biol. 2013 Nov 18; 23(22):2288-95. PMID: 24210614; PMCID: PMC3912999.
    36. Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg M. The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open. 2013; 2(10):1007-12. PMID: 24167710; PMCID: PMC3798183.
    37. Gingras AR, Puzon-McLaughlin W, Ginsberg M. The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail. J Biol Chem. 2013 Aug 16; 288(33):23639-49. PMID: 23814056; PMCID: PMC3745310.
    38. Lee HS, Anekal P, Lim CJ, Liu CC, Ginsberg M. Two modes of integrin activation form a binary molecular switch in adhesion maturation. Mol Biol Cell. 2013 May; 24(9):1354-62. PMID: 23468527; PMCID: PMC3639047.
    39. Gingras AR, Ye F, Ginsberg M. Reconstructing integrin activation in vitro. Methods Mol Biol. 2013; 1046:1-17. PMID: 23868579.
      View in: PubMed
    40. Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg M, Teitelbaum SL. Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol. 2013 Feb; 33(4):830-44. PMID: 23230271; PMCID: PMC3571341.
    41. Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg M, Collard JG, Kaibuchi K. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol. 2012 Oct 15; 199(2):331-45. PMID: 23071154; PMCID: PMC3471226.
    42. Gingras AR, Liu JJ, Ginsberg M. Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. J Cell Biol. 2012 Oct 01; 199(1):39-48. PMID: 23007647; PMCID: PMC3461514.
    43. Kim C, Ye F, Hu X, Ginsberg M. Talin activates integrins by altering the topology of the ß transmembrane domain. J Cell Biol. 2012 May 28; 197(5):605-11. PMID: 22641344; PMCID: PMC3365499.
    44. Kahner BN, Kato H, Banno A, Ginsberg M, Shattil SJ, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to aIIbß3. PLoS One. 2012; 7(3):e34056. PMID: 22457811; PMCID: PMC3311585.
    45. Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg M, Fässler R, Ley K. Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood. 2012 May 03; 119(18):4275-82. PMID: 22431571; PMCID: PMC3359742.
    46. Cantor JM, Ginsberg M. CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci. 2012 Mar 15; 125(Pt 6):1373-82. PMID: 22499670; PMCID: PMC3336374.
    47. Banno A, Goult BT, Lee H, Bate N, Critchley DR, Ginsberg M. Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem. 2012 Apr 20; 287(17):13799-812. PMID: 22351767; PMCID: PMC3340173.
    48. Kim C, Schmidt T, Cho EG, Ye F, Ulmer TS, Ginsberg M. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature. 2011 Dec 18; 481(7380):209-13. PMID: 22178926; PMCID: PMC3257387.
    49. Kim J, Sherman NE, Fox JW, Ginsberg M. Phosphorylation sites in the cerebral cavernous malformations complex. J Cell Sci. 2011 Dec 01; 124(Pt 23):3929-32. PMID: 22194303; PMCID: PMC3244978.
    50. McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg M, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke. 2012 Feb; 43(2):571-4. PMID: 22034008; PMCID: PMC3265629.
    51. Gutierrez E, Tkachenko E, Besser A, Sundd P, Ley K, Danuser G, Ginsberg M, Groisman A. High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One. 2011; 6(9):e23807. PMID: 21961031; PMCID: PMC3178539.
    52. Ye F, Kim C, Ginsberg M. Reconstruction of integrin activation. Blood. 2012 Jan 05; 119(1):26-33. PMID: 21921044; PMCID: PMC3251231.
    53. Ye F, Kim C, Ginsberg M. Molecular mechanism of inside-out integrin regulation. J Thromb Haemost. 2011 Jul; 9 Suppl 1:20-25. PMID: 21781238; PMCID: PMC3979599.
    54. Sundd P, Gutierrez E, Petrich BG, Ginsberg M, Groisman A, Ley K. Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation. 2011 Jul; 18(5):361-72. PMID: 21418380; PMCID: PMC3123727.
    55. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg M, Cheresh DA, Hirsch E, Field SJ, Varner JA. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. PMID: 21665146; PMCID: PMC3144144.
    56. Cantor J, Slepak M, Ege N, Chang JT, Ginsberg M. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol. 2011 Jul 15; 187(2):851-60. PMID: 21670318; PMCID: PMC3131465.
    57. Kim C, Ye F, Ginsberg M. Regulation of integrin activation. Annu Rev Cell Dev Biol. 2011; 27:321-45. PMID: 21663444.
      View in: PubMed
    58. Liu JJ, Stockton RA, Gingras AR, Ablooglu AJ, Han J, Bobkov AA, Ginsberg M. A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell. 2011 Jul 15; 22(14):2509-19. PMID: 21633110; PMCID: PMC3135476.
    59. Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg M. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol. 2011 Jun; 13(6):660-7. PMID: 21572420; PMCID: PMC3746034.
    60. Ring C, Ginsberg M, Haling J, Pendergast AM. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):149-54. PMID: 21173240; PMCID: PMC3017183.
    61. Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg M, Pritchard CA, Critchley DR. Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol. 2011 Jan 15; 349(2):494-502. PMID: 21081121; PMCID: PMC3025397.
    62. McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg M, Awad IA, Marchuk DA. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet. 2011 Jan 15; 20(2):211-22. PMID: 20940147; PMCID: PMC3005897.
    63. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. PMID: 20388801; PMCID: PMC2856096.
    64. Shattil SJ, Kim C, Ginsberg M. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010 Apr; 11(4):288-300. PMID: 20308986; PMCID: PMC3929966.
    65. Stockton RA, Shenkar R, Awad IA, Ginsberg M. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med. 2010 Apr 12; 207(4):881-96. PMID: 20308363; PMCID: PMC2856024.
    66. Kummer C, Petrich BG, Rose DM, Ginsberg M. A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. J Biol Chem. 2010 Mar 26; 285(13):9462-9. PMID: 20097761; PMCID: PMC2843196.
    67. Ye F, Hu G, Taylor D, Ratnikov B, Bobkov AA, McLean MA, Sligar SG, Taylor KA, Ginsberg M. Recreation of the terminal events in physiological integrin activation. J Cell Biol. 2010 Jan 11; 188(1):157-73. PMID: 20048261; PMCID: PMC2812850.
    68. Haling JR, Wang F, Ginsberg M. Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha. Mol Biol Cell. 2010 Feb 15; 21(4):664-73. PMID: 20032303; PMCID: PMC2820429.
    69. Glading AJ, Ginsberg M. Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech. 2010 Jan-Feb; 3(1-2):73-83. PMID: 20007487; PMCID: PMC2806902.
    70. Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg M, Campbell ID. Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J Biol Chem. 2009 Dec 25; 284(52):36700-10. PMID: 19843520; PMCID: PMC2794784.
    71. Fogelstrand P, Féral CC, Zargham R, Ginsberg M. Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2). J Exp Med. 2009 Oct 26; 206(11):2397-406. PMID: 19841087; PMCID: PMC2768859.
    72. Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg M, Li DY. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol. 2009 Nov; 11(11):1325-31. PMID: 19855388; PMCID: PMC2854659.
    73. Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg M, Campbell ID. The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J. 2009 Nov 18; 28(22):3623-32. PMID: 19798053; PMCID: PMC2782098.
    74. Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg M. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol. 2009 May; 11(5):624-30. PMID: 19363486; PMCID: PMC2714540.
    75. Lau TL, Kim C, Ginsberg M, Ulmer TS. The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J. 2009 May 06; 28(9):1351-61. PMID: 19279667; PMCID: PMC2683045.
    76. Cantor J, Browne CD, Ruppert R, Féral CC, Fässler R, Rickert RC, Ginsberg M. CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol. 2009 Apr; 10(4):412-9. PMID: 19270713; PMCID: PMC2672195.
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