Christina Sigurdson

Title(s)Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0612
La Jolla CA 92093
Phone858-534-0978
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    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular basis of prion protein-induced neurodegeneration
    NIH RF1NS121992Jun 1, 2021 - May 31, 2024
    Role: Principal Investigator
    FASEB SRC on Protein Aggregation, from Structural Variants to in Vivo Sequela
    NIH R13NS111914Jun 1, 2019 - May 31, 2020
    Role: Principal Investigator
    Probing prion clearance through interstitial fluid and perivascular pathways
    NIH R21NS110409Sep 30, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Molecular basis of spongiform encephalopathy in prion disease
    NIH R21NS105498Aug 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    UCSD Research Training Program for Veterinarians
    NIH T32OD017863May 2, 2014 - Apr 30, 2024
    Role: Principal Investigator
    Mechanisms of Prion Spread
    NIH R01NS076896Sep 15, 2012 - Apr 30, 2022
    Role: Principal Investigator
    Mechanisms of Prion Aggregation
    NIH R01NS069566Mar 15, 2011 - Apr 30, 2026
    Role: Principal Investigator
    Infectious prion generation by mouse transgenesis
    NIH R21NS055116Aug 15, 2007 - Jul 31, 2010
    Role: Principal Investigator
    BRIDGES TO THE BACCALAUREATE PROGRAM AT SAN DIEGO MESA COLLEGE
    NIH R25GM073590Jul 1, 2005 - May 31, 2020
    Role: Co-Principal Investigator
    CWD: ROLE OF THE LYMPHOID TISSUE PHASE IN PRION DISEASE
    NIH K08AI001802Aug 1, 2000 - Jul 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol. 2021 Jun 01; 10(7):5. Cao KJ, Kim JH, Kroeger H, Gaffney PM, Lin JH, Sigurdson CJ, Yang J. PMID: 34096989.
      View in: PubMed   Mentions:
    2. Scaling analysis reveals the mechanism and rates of prion replication in vivo. Nat Struct Mol Biol. 2021 04; 28(4):365-372. Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, Michaels TCT, Heinzer D, Avar M, Cohen SIA, Hornemann S, Aguzzi A, Dobson CM, Sigurdson CJ, Knowles TPJ. PMID: 33767451.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission. PLoS Pathog. 2021 01; 17(1):e1009123. Aguilar-Calvo P, Callender JA, Sigurdson CJ. PMID: 33444414.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. J Neuropathol Exp Neurol. 2020 11 01; 79(11):1141-1146. Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, Montine TJ, Morgello S, Phelps C, Safar J, Schneider JA, Schonberger LB, Sigurdson C, Silverberg N, Trojanowski JQ, Frosch MP. PMID: 33000167.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    5. A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. J Biol Chem. 2020 10 09; 295(41):14178-14188. Mantuano E, Azmoon P, Banki MA, Lam MS, Sigurdson CJ, Gonias SL. PMID: 32788217.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease. Neurobiol Dis. 2020 08; 142:104955. Callender JA, Sevillano AM, Soldau K, Kurt TD, Schumann T, Pizzo DP, Altmeppen H, Glatzel M, Esko JD, Sigurdson CJ. PMID: 32454127.
      View in: PubMed   Mentions: 2     Fields:    
    7. Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease. J Clin Invest. 2020 03 02; 130(3):1350-1362. Sevillano AM, Aguilar-Calvo P, Kurt TD, Lawrence JA, Soldau K, Nam TH, Schumann T, Pizzo DP, Nyström S, Choudhury B, Altmeppen H, Esko JD, Glatzel M, Nilsson KPR, Sigurdson CJ. PMID: 31985492.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions. Acta Neuropathol. 2020 03; 139(3):527-546. Aguilar-Calvo P, Sevillano AM, Bapat J, Soldau K, Sandoval DR, Altmeppen HC, Linsenmeier L, Pizzo DP, Geschwind MD, Sanchez H, Appleby BS, Cohen ML, Safar JG, Edland SD, Glatzel M, Nilsson KPR, Esko JD, Sigurdson CJ. PMID: 31673874.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    9. Cryo-EM structure and polymorphism of Aß amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun. 2019 10 29; 10(1):4760. Kollmer M, Close W, Funk L, Rasmussen J, Bsoul A, Schierhorn A, Schmidt M, Sigurdson CJ, Jucker M, Fändrich M. PMID: 31664019.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    10. Recent advances on the molecular pathogenesis of prion diseases. Brain Pathol. 2019 03; 29(2):245-247. Glatzel M, Sigurdson CJ. PMID: 30588674.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease. Acta Neuropathol. 2019 04; 137(4):585-598. Kraus A, Saijo E, Metrick MA, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B. PMID: 30570675.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    12. Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients. mBio. 2018 11 20; 9(6). Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ. PMID: 30459197.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    13. Cellular and Molecular Mechanisms of Prion Disease. Annu Rev Pathol. 2019 01 24; 14:497-516. Sigurdson CJ, Bartz JC, Glatzel M. PMID: 30355150.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    14. Generation of novel neuroinvasive prions following intravenous challenge. Brain Pathol. 2018 11; 28(6):999-1011. Aguilar-Calvo P, Bett C, Sevillano AM, Kurt TD, Lawrence J, Soldau K, Hammarström P, Nilsson KPR, Sigurdson CJ. PMID: 29505163.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids. Sci Rep. 2018 05 03; 8(1):6950. Cao KJ, Elbel KM, Cifelli JL, Cirera J, Sigurdson CJ, Paesani F, Theodorakis EA, Yang J. PMID: 29725045.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice. Prion. 2017 11 02; 11(6):431-439. Sikorska B, Gajos A, Bogucki A, Zielonka E, Sigurdson C, Liberski PP. PMID: 29105545.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem. 2017 11 17; 292(46):19076-19086. Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ. PMID: 28931606.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 04 21; 5(1):32. Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. PMID: 28431576.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Sci Rep. 2017 03 08; 7:43295. Aguilar-Calvo P, Xiao X, Bett C, Eraña H, Soldau K, Castilla J, Nilsson KP, Surewicz WK, Sigurdson CJ. PMID: 28272426.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    20. Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines. Pathobiol Aging Age Relat Dis. 2016; 6:32397. Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W. PMID: 27317189.
      View in: PubMed   Mentions:
    21. Polymorphism of Amyloid Fibrils In Vivo. Angew Chem Int Ed Engl. 2016 Apr 04; 55(15):4822-5. Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M. PMID: 26954430.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    22. Cross-species transmission of CWD prions. Prion. 2016; 10(1):83-91. Kurt TD, Sigurdson CJ. PMID: 26809254.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    23. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. PMID: 26799652.
      View in: PubMed   Mentions: 2028     Fields:    Translation:HumansAnimals
    24. A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry. 2015 Oct 19; 21(43):15133-7. Shirani H, Linares M, Sigurdson CJ, Lindgren M, Norman P, Nilsson KP. PMID: 26388448.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    25. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25961458.
      View in: PubMed   Mentions: 4     Fields:    
    26. Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol. 2015 Jul; 185(7):1800-8. Hiramatsu N, Chiang WC, Kurt TD, Sigurdson CJ, Lin JH. PMID: 25956028.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    27. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25705888.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One. 2014; 9(11):e113765. Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C. PMID: 25429466.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    29. Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J. 2015 Mar; 29(3):911-9. Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E, Sigurdson CJ. PMID: 25422367.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion. 2014; 8(4):319-29. Magnusson K, Simon R, Sjölander D, Sigurdson CJ, Hammarström P, Nilsson KP. PMID: 25495506.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    31. A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the ß2-a2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-10667. Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson CJ. PMID: 24596090.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    32. Prion transmission prevented by modifying the ß2-a2 loop structure of host PrPC. J Neurosci. 2014 Jan 15; 34(3):1022-7. Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson CJ. PMID: 24431459.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    33. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb; 88(4):2071-82. Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson CJ. PMID: 24307586.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    34. The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates. Chemistry. 2013 Jul 29; 19(31):10179-92. Klingstedt T, Shirani H, Åslund KO, Cairns NJ, Sigurdson CJ, Goedert M, Nilsson KP. PMID: 23780508.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    35. Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS Pathog. 2013; 9(4):e1003280. Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB, Sigurdson CJ. PMID: 23637596.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    36. Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb; 94(Pt 2):432-442. Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. PMID: 23100363.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    37. Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-ß and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41. Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis EA, Yang J. PMID: 22866977.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS One. 2012; 7(6):e39055. Mitchell GB, Sigurdson CJ, O'Rourke KI, Algire J, Harrington NP, Walther I, Spraker TR, Balachandran A. PMID: 22723928.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    39. Structure of the ß2-a2 loop and interspecies prion transmission. FASEB J. 2012 Jul; 26(7):2868-76. Bett C, Fernández-Borges N, Kurt TD, Lucero M, Nilsson KP, Castilla J, Sigurdson CJ. PMID: 22490928.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    40. Prion infection promotes extensive accumulation of a-synuclein in aged human a-synuclein transgenic mice. Prion. 2012 Apr-Jun; 6(2):184-90. Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M, Sigurdson CJ. PMID: 22460692.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    41. PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP. PLoS Pathog. 2012; 8(3):e1002547. Sajnani G, Silva CJ, Ramos A, Pastrana MA, Onisko BC, Erickson ML, Antaki EM, Dynin I, Vázquez-Fernández E, Sigurdson CJ, Carter JM, Requena JR. PMID: 22396643.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    42. Biochemical properties of highly neuroinvasive prion strains. PLoS Pathog. 2012 Feb; 8(2):e1002522. Bett C, Joshi-Barr S, Lucero M, Trejo M, Liberski P, Kelly JW, Masliah E, Sigurdson CJ. PMID: 22319450.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    43. Spongiform encephalopathy in transgenic mice expressing a point mutation in the ß2-a2 loop of the prion protein. J Neurosci. 2011 Sep 28; 31(39):13840-7. Sigurdson CJ, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A. PMID: 21957246.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    44. Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets. J Gen Virol. 2012 Jan; 93(Pt 1):212-221. Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. PMID: 21918005.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    45. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255. Chang WM, Dakanali M, Capule CC, Sigurdson CJ, Yang J, Theodorakis EA. PMID: 21743829.
      View in: PubMed   Mentions: 19     Fields:    
    46. Tracking protein aggregate interactions. Prion. 2011 Apr-Jun; 5(2):52-5. Sigurdson CJ, Bartz JC, Nilsson KP. PMID: 21597336.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    47. Sheep with scrapie and mastitis transmit infectious prions through the milk. J Virol. 2011 Jan; 85(2):1136-9. Ligios C, Cancedda MG, Carta A, Santucciu C, Maestrale C, Demontis F, Saba M, Patta C, DeMartini JC, Aguzzi A, Sigurdson CJ. PMID: 21084475.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    48. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 12; 6(12):702-6. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. PMID: 21045796.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    49. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24. Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. PMID: 20695487.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    50. Prion strain interactions are highly selective. J Neurosci. 2010 Sep 08; 30(36):12094-102. Nilsson KP, Joshi-Barr S, Winson O, Sigurdson CJ. PMID: 20826672.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    51. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010 Oct; 91(Pt 10):2651-7. Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. PMID: 20610667.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    52. A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest. 2010 Jul; 120(7):2590-9. Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Fernández-Borges N, Schwarz P, Castilla J, Wüthrich K, Aguzzi A. PMID: 20551516.
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    53. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21; 4(8):673-84. Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. PMID: 19624097.
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    54. Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis. 2009 Jan 15; 199(2):243-52. Sigurdson CJ, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A. PMID: 19072552.
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    55. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 2008 Dec 19; 29(6):998-1008. Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A. PMID: 19100703.
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    56. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):304-9. Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. PMID: 19073920.
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    57. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One. 2008; 3(12):e3872. Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A. PMID: 19060956.
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    58. A prion disease of cervids: chronic wasting disease. Vet Res. 2008 Jul-Aug; 39(4):41. Sigurdson CJ. PMID: 18381058.
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    59. Molecular mechanisms of prion pathogenesis. Annu Rev Pathol. 2008; 3:11-40. Aguzzi A, Sigurdson C, Heikenwaelder M. PMID: 18233951.
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    60. Prion strain discrimination using luminescent conjugated polymers. Nat Methods. 2007 Dec; 4(12):1023-30. Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. PMID: 18026110.
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    61. Chronic wasting disease. Biochim Biophys Acta. 2007 Jun; 1772(6):610-8. Sigurdson CJ, Aguzzi A. PMID: 17223321.
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    62. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006 Oct 06; 314(5796):133-6. Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hays SA, Hayes-Klug J, Seelig DM, Wild MA, Wolfe LL, Spraker TR, Miller MW, Sigurdson CJ, Telling GC, Hoover EA. PMID: 17023660.
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    63. Strain fidelity of chronic wasting disease upon murine adaptation. J Virol. 2006 Dec; 80(24):12303-11. Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. PMID: 17020952.
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    64. Prions in skeletal muscles of deer with chronic wasting disease. Science. 2006 Feb 24; 311(5764):1117. Angers RC, Browning SR, Seward TS, Sigurdson CJ, Miller MW, Hoover EA, Telling GC. PMID: 16439622.
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    65. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med. 2005 Nov; 11(11):1137-8. Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, Maestrale C, Cancedda MG, Madau L, Aguzzi A. PMID: 16270061.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    66. Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy". Vet Pathol. 2005 Jan; 42(1):107. Sigurdson C, Glatzel M, Aguzzi A. PMID: 15657284.
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    67. Reconstructing prions: fibril assembly from simple yeast to complex mammals. Neurodegener Dis. 2005; 2(1):1-5. Sigurdson C, Polymenidou M, Aguzzi A. PMID: 16908997.
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    68. Antiprion immunotherapy: to suppress or to stimulate? Nat Rev Immunol. 2004 Sep; 4(9):725-36. Aguzzi A, Sigurdson CJ. PMID: 15343371.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    69. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med. 2004 Feb; 10(2):187-92. Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A. PMID: 14745443.
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    70. Other animal prion diseases. Br Med Bull. 2003; 66:199-212. Sigurdson CJ, Miller MW. PMID: 14522860.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    71. PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer. J Gen Virol. 2002 Oct; 83(Pt 10):2617-2628. Sigurdson CJ, Barillas-Mury C, Miller MW, Oesch B, van Keulen LJM, Langeveld JPM, Hoover EA. PMID: 12237446.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    72. Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy. J Gen Virol. 2002 Oct; 83(Pt 10):2629-2634. Wild MA, Spraker TR, Sigurdson CJ, O'Rourke KI, Miller MW. PMID: 12237447.
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    73. PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease. J Gen Virol. 2001 Oct; 82(Pt 10):2327-2334. Sigurdson CJ, Spraker TR, Miller MW, Oesch B, Hoover EA. PMID: 11562526.
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    74. Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol. 1999 Oct; 80 ( Pt 10):2757-2764. Sigurdson CJ, Williams ES, Miller MW, Spraker TR, O'Rourke KI, Hoover EA. PMID: 10573172.
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