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    Christina Sigurdson

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
    Phone858-534-0978
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      Collapse Research 
      Collapse Research Activities and Funding
      UCSD Research Training Program for Veterinarians
      NIH T32OD017863May 2, 2014 - Apr 30, 2019
      Role: Principal Investigator
      Mechanisms of Prion Spread
      NIH/NINDS R01NS076896Sep 15, 2012 - Apr 30, 2022
      Role: Principal Investigator
      Mechanisms of Prion Aggregation and Species Barriers
      NIH/NINDS R01NS069566Mar 15, 2011 - Jun 30, 2021
      Role: Principal Investigator
      Infectious prion generation by mouse transgenesis
      NIH/NINDS R21NS055116Aug 15, 2007 - Jul 31, 2010
      Role: Principal Investigator
      BRIDGES TO THE BACCALAUREATE PROGRAM AT SAN DIEGO MESA COLLEGE
      NIH/NIGMS R25GM073590Jul 1, 2005 - May 31, 2019
      Role: Co-Principal Investigator
      CWD: ROLE OF THE LYMPHOID TISSUE PHASE IN PRION DISEASE
      NIH/NIAID K08AI001802Aug 1, 2000 - Jul 31, 2005
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Aguilar-Calvo P, Xiao X, Bett C, Eraña H, Soldau K, Castilla J, Nilsson KP, Surewicz WK, Sigurdson C. Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Sci Rep. 2017 Mar 08; 7:43295. PMID: 28272426.
        View in: PubMed
      2. Kurt TD, Sigurdson C. Cross-species transmission of CWD prions. Prion. 2016; 10(1):83-91. PMID: 26809254; PMCID: PMC4981193 [Available on 01/25/17].
      3. Shirani H, Linares M, Sigurdson C, Lindgren M, Norman P, Nilsson KP. A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry. 2015 Oct 19; 21(43):15133-7. PMID: 26388448; PMCID: PMC4641461.
      4. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson C. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. PMID: 25961458; PMCID: PMC4497774.
      5. Hiramatsu N, Chiang WC, Kurt TD, Sigurdson C, Lin JH. Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol. 2015 Jul; 185(7):1800-8. PMID: 25956028; PMCID: PMC4484218.
      6. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson C. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96. PMID: 25705888; PMCID: PMC4396485.
      7. Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C. Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One. 2014; 9(11):e113765. PMID: 25429466; PMCID: PMC4245998.
      8. Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E, Sigurdson C. Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J. 2015 Mar; 29(3):911-9. PMID: 25422367.
        View in: PubMed
      9. Magnusson K, Simon R, Sjölander D, Sigurdson C, Hammarström P, Nilsson KP. Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion. 2014; 8(4):319-29. PMID: 25495506; PMCID: PMC4601348.
      10. Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson C. A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the ß2-a2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-7. PMID: 24596090; PMCID: PMC4036184.
      11. Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson C. Prion transmission prevented by modifying the ß2-a2 loop structure of host PrPC. J Neurosci. 2014 Jan 15; 34(3):1022-7. PMID: 24431459; PMCID: PMC3891945.
      12. Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson C. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb; 88(4):2071-82. PMID: 24307586; PMCID: PMC3911572.
      13. Klingstedt T, Shirani H, Åslund KO, Cairns NJ, Sigurdson C, Goedert M, Nilsson KP. The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates. Chemistry. 2013 Jul 29; 19(31):10179-92. PMID: 23780508; PMCID: PMC3884759.
      14. Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB, Sigurdson C. Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS Pathog. 2013; 9(4):e1003280. PMID: 23637596; PMCID: PMC3630170.
      15. Perrott MR, Sigurdson C, Mason GL, Hoover EA. Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb; 94(Pt 2):432-42. PMID: 23100363; PMCID: PMC3709615.
      16. Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson C, Theodorakis EA, Yang J. Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-ß and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41. PMID: 22866977; PMCID: PMC3480552.
      17. Mitchell GB, Sigurdson C, O'Rourke KI, Algire J, Harrington NP, Walther I, Spraker TR, Balachandran A. Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS One. 2012; 7(6):e39055. PMID: 22723928; PMCID: PMC3377593.
      18. Bett C, Fernández-Borges N, Kurt TD, Lucero M, Nilsson KP, Castilla J, Sigurdson C. Structure of the ß2-a2 loop and interspecies prion transmission. FASEB J. 2012 Jul; 26(7):2868-76. PMID: 22490928; PMCID: PMC3382101.
      19. Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M, Sigurdson C. Prion infection promotes extensive accumulation of a-synuclein in aged human a-synuclein transgenic mice. Prion. 2012 Apr-Jun; 6(2):184-90. PMID: 22460692; PMCID: PMC3366356.
      20. Bett C, Joshi-Barr S, Lucero M, Trejo M, Liberski P, Kelly JW, Masliah E, Sigurdson C. Biochemical properties of highly neuroinvasive prion strains. PLoS Pathog. 2012 Feb; 8(2):e1002522. PMID: 22319450; PMCID: PMC3271082.
      21. Sigurdson C, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A. Spongiform encephalopathy in transgenic mice expressing a point mutation in the ß2-a2 loop of the prion protein. J Neurosci. 2011 Sep 28; 31(39):13840-7. PMID: 21957246; PMCID: PMC3205959.
      22. Chang WM, Dakanali M, Capule CC, Sigurdson C, Yang J, Theodorakis EA. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255. PMID: 21743829.
        View in: PubMed
      23. Sigurdson C, Bartz JC, Nilsson KP. Tracking protein aggregate interactions. Prion. 2011 Apr-Jun; 5(2):52-5. PMID: 21597336; PMCID: PMC3166500.
      24. Ligios C, Cancedda MG, Carta A, Santucciu C, Maestrale C, Demontis F, Saba M, Patta C, DeMartini JC, Aguzzi A, Sigurdson C. Sheep with scrapie and mastitis transmit infectious prions through the milk. J Virol. 2011 Jan; 85(2):1136-9. PMID: 21084475; PMCID: PMC3020009.
      25. Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24. PMID: 20695487; PMCID: PMC2996463.
      26. Nilsson KP, Joshi-Barr S, Winson O, Sigurdson C. Prion strain interactions are highly selective. J Neurosci. 2010 Sep 08; 30(36):12094-102. PMID: 20826672; PMCID: PMC2951977.
      27. Sandberg MK, Al-Doujaily H, Sigurdson C, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010 Oct; 91(Pt 10):2651-7. PMID: 20610667; PMCID: PMC3052602.
      28. Sigurdson C, Nilsson KP, Hornemann S, Manco G, Fernández-Borges N, Schwarz P, Castilla J, Wüthrich K, Aguzzi A. A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest. 2010 Jul; 120(7):2590-9. PMID: 20551516; PMCID: PMC2898603.
      29. Aslund A, Sigurdson C, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21; 4(8):673-84. PMID: 19624097; PMCID: PMC2886514.
      30. Sigurdson C, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A. Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis. 2009 Jan 15; 199(2):243-52. PMID: 19072552; PMCID: PMC2822447.
      31. Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson C, Aguzzi A. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 2008 Dec 19; 29(6):998-1008. PMID: 19100703.
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      32. Sigurdson C, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):304-9. PMID: 19073920; PMCID: PMC2629180.
      33. Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One. 2008; 3(12):e3872. PMID: 19060956; PMCID: PMC2592702.
      34. Sigurdson C. A prion disease of cervids: chronic wasting disease. Vet Res. 2008 Jul-Aug; 39(4):41. PMID: 18381058.
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      35. Aguzzi A, Sigurdson C, Heikenwaelder M. Molecular mechanisms of prion pathogenesis. Annu Rev Pathol. 2008; 3:11-40. PMID: 18233951.
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      36. Sigurdson C, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. Prion strain discrimination using luminescent conjugated polymers. Nat Methods. 2007 Dec; 4(12):1023-30. PMID: 18026110.
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      37. Sigurdson C, Aguzzi A. Chronic wasting disease. Biochim Biophys Acta. 2007 Jun; 1772(6):610-8. PMID: 17223321; PMCID: PMC2680674.
      38. Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hays SA, Hayes-Klug J, Seelig DM, Wild MA, Wolfe LL, Spraker TR, Miller MW, Sigurdson C, Telling GC, Hoover EA. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006 Oct 06; 314(5796):133-6. PMID: 17023660.
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      39. Sigurdson C, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. Strain fidelity of chronic wasting disease upon murine adaptation. J Virol. 2006 Dec; 80(24):12303-11. PMID: 17020952; PMCID: PMC1676299.
      40. Angers RC, Browning SR, Seward TS, Sigurdson C, Miller MW, Hoover EA, Telling GC. Prions in skeletal muscles of deer with chronic wasting disease. Science. 2006 Feb 24; 311(5764):1117. PMID: 16439622.
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      41. Ligios C, Sigurdson C, Santucciu C, Carcassola G, Manco G, Basagni M, Maestrale C, Cancedda MG, Madau L, Aguzzi A. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med. 2005 Nov; 11(11):1137-8. PMID: 16270061.
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      42. Sigurdson C, Polymenidou M, Aguzzi A. Reconstructing prions: fibril assembly from simple yeast to complex mammals. Neurodegener Dis. 2005; 2(1):1-5. PMID: 16908997.
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      43. Sigurdson C, Glatzel M, Aguzzi A. Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy". Vet Pathol. 2005 Jan; 42(1):107. PMID: 15657284.
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      44. Aguzzi A, Sigurdson C. Antiprion immunotherapy: to suppress or to stimulate? Nat Rev Immunol. 2004 Sep; 4(9):725-36. PMID: 15343371.
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      45. Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med. 2004 Feb; 10(2):187-92. PMID: 14745443.
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      46. Sigurdson C, Miller MW. Other animal prion diseases. Br Med Bull. 2003; 66:199-212. PMID: 14522860.
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      47. Sigurdson C, Barillas-Mury C, Miller MW, Oesch B, van Keulen LJ, Langeveld JP, Hoover EA. PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer. J Gen Virol. 2002 Oct; 83(Pt 10):2617-28. PMID: 12237446.
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      48. Wild MA, Spraker TR, Sigurdson C, O'Rourke KI, Miller MW. Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy. J Gen Virol. 2002 Oct; 83(Pt 10):2629-34. PMID: 12237447.
        View in: PubMed
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