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Christina Sigurdson

Title(s)Professor, Medicine
SchoolHealth Sciences
Phone858-534-0978
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    Collapse Research 
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    FASEB SRC on Protein Aggregation, from Structural Variants to in Vivo Sequela
    NIH/NINDS R13NS111914Jun 1, 2019 - May 31, 2020
    Role: Principal Investigator
    Probing prion clearance through interstitial fluid and perivascular pathways
    NIH/NINDS R21NS110409Sep 30, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Molecular basis of spongiform encephalopathy in prion disease
    NIH/NINDS R21NS105498Aug 1, 2018 - Jul 31, 2020
    Role: Principal Investigator
    UCSD Research Training Program for Veterinarians
    NIH T32OD017863May 2, 2014 - Apr 30, 2024
    Role: Principal Investigator
    Mechanisms of Prion Spread
    NIH/NINDS R01NS076896Sep 15, 2012 - Apr 30, 2022
    Role: Principal Investigator
    Mechanisms of Prion Aggregation and Species Barriers
    NIH/NINDS R01NS069566Mar 15, 2011 - Jun 30, 2021
    Role: Principal Investigator
    Infectious prion generation by mouse transgenesis
    NIH/NINDS R21NS055116Aug 15, 2007 - Jul 31, 2010
    Role: Principal Investigator
    BRIDGES TO THE BACCALAUREATE PROGRAM AT SAN DIEGO MESA COLLEGE
    NIH/NIGMS R25GM073590Jul 1, 2005 - May 31, 2019
    Role: Co-Principal Investigator
    CWD: ROLE OF THE LYMPHOID TISSUE PHASE IN PRION DISEASE
    NIH/NIAID K08AI001802Aug 1, 2000 - Jul 31, 2005
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Glatzel M, Sigurdson CJ. Recent advances on the molecular pathogenesis of prion diseases. Brain Pathol. 2019 03; 29(2):245-247. PMID: 30588674.
      View in: PubMed
    2. Kraus A, Saijo E, Metrick MA, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B. Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease. Acta Neuropathol. 2019 Apr; 137(4):585-598. PMID: 30570675.
      View in: PubMed
    3. Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ. Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients. MBio. 2018 11 20; 9(6). PMID: 30459197.
      View in: PubMed
    4. Sigurdson CJ, Bartz JC, Glatzel M. Cellular and Molecular Mechanisms of Prion Disease. Annu Rev Pathol. 2019 Jan 24; 14:497-516. PMID: 30355150.
      View in: PubMed
    5. Aguilar-Calvo P, Bett C, Sevillano AM, Kurt TD, Lawrence J, Soldau K, Hammarström P, Nilsson KPR, Sigurdson CJ. Generation of novel neuroinvasive prions following intravenous challenge. Brain Pathol. 2018 11; 28(6):999-1011. PMID: 29505163.
      View in: PubMed
    6. Cao KJ, Elbel KM, Cifelli JL, Cirera J, Sigurdson CJ, Paesani F, Theodorakis EA, Yang J. Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids. Sci Rep. 2018 May 03; 8(1):6950. PMID: 29725045.
      View in: PubMed
    7. Sikorska B, Gajos A, Bogucki A, Zielonka E, Sigurdson C, Liberski PP. Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice. Prion. 2017 11 02; 11(6):431-439. PMID: 29105545.
      View in: PubMed
    8. Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ. Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem. 2017 11 17; 292(46):19076-19086. PMID: 28931606.
      View in: PubMed
    9. Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 04 21; 5(1):32. PMID: 28431576.
      View in: PubMed
    10. Aguilar-Calvo P, Xiao X, Bett C, Eraña H, Soldau K, Castilla J, Nilsson KP, Surewicz WK, Sigurdson CJ. Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Sci Rep. 2017 03 08; 7:43295. PMID: 28272426.
      View in: PubMed
    11. Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W. Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines. Pathobiol Aging Age Relat Dis. 2016; 6:32397. PMID: 27317189.
      View in: PubMed
    12. Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M. Polymorphism of Amyloid Fibrils In Vivo. Angew Chem Int Ed Engl. 2016 Apr 04; 55(15):4822-5. PMID: 26954430; PMCID: PMC4864496 [Available on 04/04/17].
      View in: PubMed, PubMed Central
    13. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    14. Kurt TD, Sigurdson CJ. Cross-species transmission of CWD prions. Prion. 2016; 10(1):83-91. PMID: 26809254; PMCID: PMC4981193 [Available on 01/25/17].
      View in: PubMed, PubMed Central
    15. Gaffney PM, Witte C, Clifford DL, Imai DM, O'Brien TD, Trejo M, Liberta F, Annamalai K, Fändrich M, Masliah E, Munson L, Sigurdson CJ. Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors. Vet Pathol. 2016 May; 53(3):637-47. PMID: 26419399.
      View in: PubMed
    16. Shirani H, Linares M, Sigurdson CJ, Lindgren M, Norman P, Nilsson KP. A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry. 2015 Oct 19; 21(43):15133-7. PMID: 26388448.
      View in: PubMed
    17. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. PMID: 25961458; PMCID: PMC4497774.
      View in: PubMed, PubMed Central
    18. Hiramatsu N, Chiang WC, Kurt TD, Sigurdson CJ, Lin JH. Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol. 2015 Jul; 185(7):1800-8. PMID: 25956028; PMCID: PMC4484218.
      View in: PubMed, PubMed Central
    19. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96. PMID: 25705888; PMCID: PMC4396485.
      View in: PubMed, PubMed Central
    20. Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C. Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One. 2014; 9(11):e113765. PMID: 25429466; PMCID: PMC4245998.
      View in: PubMed, PubMed Central
    21. Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E, Sigurdson CJ. Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J. 2015 Mar; 29(3):911-9. PMID: 25422367.
      View in: PubMed
    22. Magnusson K, Simon R, Sjölander D, Sigurdson CJ, Hammarström P, Nilsson KP. Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion. 2014; 8(4):319-29. PMID: 25495506; PMCID: PMC4601348.
      View in: PubMed, PubMed Central
    23. Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson CJ. A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the ß2-a2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-7. PMID: 24596090; PMCID: PMC4036184.
      View in: PubMed, PubMed Central
    24. Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A, Sigurdson CJ. Prion transmission prevented by modifying the ß2-a2 loop structure of host PrPC. J Neurosci. 2014 Jan 15; 34(3):1022-7. PMID: 24431459; PMCID: PMC3891945.
      View in: PubMed, PubMed Central
    25. Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson CJ. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb; 88(4):2071-82. PMID: 24307586; PMCID: PMC3911572.
      View in: PubMed, PubMed Central
    26. Klingstedt T, Shirani H, Åslund KO, Cairns NJ, Sigurdson CJ, Goedert M, Nilsson KP. The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates. Chemistry. 2013 Jul 29; 19(31):10179-92. PMID: 23780508; PMCID: PMC3884759.
      View in: PubMed, PubMed Central
    27. Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB, Sigurdson CJ. Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS Pathog. 2013; 9(4):e1003280. PMID: 23637596; PMCID: PMC3630170.
      View in: PubMed, PubMed Central
    28. Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb; 94(Pt 2):432-42. PMID: 23100363; PMCID: PMC3709615.
      View in: PubMed, PubMed Central
    29. Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis EA, Yang J. Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-ß and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41. PMID: 22866977; PMCID: PMC3480552.
      View in: PubMed, PubMed Central
    30. Mitchell GB, Sigurdson CJ, O'Rourke KI, Algire J, Harrington NP, Walther I, Spraker TR, Balachandran A. Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS One. 2012; 7(6):e39055. PMID: 22723928; PMCID: PMC3377593.
      View in: PubMed, PubMed Central
    31. Bett C, Fernández-Borges N, Kurt TD, Lucero M, Nilsson KP, Castilla J, Sigurdson CJ. Structure of the ß2-a2 loop and interspecies prion transmission. FASEB J. 2012 Jul; 26(7):2868-76. PMID: 22490928; PMCID: PMC3382101.
      View in: PubMed, PubMed Central
    32. Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M, Sigurdson CJ. Prion infection promotes extensive accumulation of a-synuclein in aged human a-synuclein transgenic mice. Prion. 2012 Apr-Jun; 6(2):184-90. PMID: 22460692; PMCID: PMC3366356.
      View in: PubMed, PubMed Central
    33. Sajnani G, Silva CJ, Ramos A, Pastrana MA, Onisko BC, Erickson ML, Antaki EM, Dynin I, Vázquez-Fernández E, Sigurdson CJ, Carter JM, Requena JR. PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP. PLoS Pathog. 2012; 8(3):e1002547. PMID: 22396643; PMCID: PMC3291653.
      View in: PubMed, PubMed Central
    34. Bett C, Joshi-Barr S, Lucero M, Trejo M, Liberski P, Kelly JW, Masliah E, Sigurdson CJ. Biochemical properties of highly neuroinvasive prion strains. PLoS Pathog. 2012 Feb; 8(2):e1002522. PMID: 22319450; PMCID: PMC3271082.
      View in: PubMed, PubMed Central
    35. Sigurdson CJ, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A. Spongiform encephalopathy in transgenic mice expressing a point mutation in the ß2-a2 loop of the prion protein. J Neurosci. 2011 Sep 28; 31(39):13840-7. PMID: 21957246; PMCID: PMC3205959.
      View in: PubMed, PubMed Central
    36. Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets. J Gen Virol. 2012 Jan; 93(Pt 1):212-21. PMID: 21918005; PMCID: PMC3352335.
      View in: PubMed, PubMed Central
    37. Chang WM, Dakanali M, Capule CC, Sigurdson CJ, Yang J, Theodorakis EA. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255. PMID: 21743829.
      View in: PubMed
    38. Sigurdson CJ, Bartz JC, Nilsson KP. Tracking protein aggregate interactions. Prion. 2011 Apr-Jun; 5(2):52-5. PMID: 21597336; PMCID: PMC3166500.
      View in: PubMed, PubMed Central
    39. Ligios C, Cancedda MG, Carta A, Santucciu C, Maestrale C, Demontis F, Saba M, Patta C, DeMartini JC, Aguzzi A, Sigurdson CJ. Sheep with scrapie and mastitis transmit infectious prions through the milk. J Virol. 2011 Jan; 85(2):1136-9. PMID: 21084475; PMCID: PMC3020009.
      View in: PubMed, PubMed Central
    40. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 12; 6(12):702-6. PMID: 21045796; PMCID: PMC4996353.
      View in: PubMed, PubMed Central
    41. Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24. PMID: 20695487; PMCID: PMC2996463.
      View in: PubMed, PubMed Central
    42. Nilsson KP, Joshi-Barr S, Winson O, Sigurdson CJ. Prion strain interactions are highly selective. J Neurosci. 2010 Sep 08; 30(36):12094-102. PMID: 20826672; PMCID: PMC2951977.
      View in: PubMed, PubMed Central
    43. Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010 Oct; 91(Pt 10):2651-7. PMID: 20610667; PMCID: PMC3052602.
      View in: PubMed, PubMed Central
    44. Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Fernández-Borges N, Schwarz P, Castilla J, Wüthrich K, Aguzzi A. A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest. 2010 Jul; 120(7):2590-9. PMID: 20551516; PMCID: PMC2898603.
      View in: PubMed, PubMed Central
    45. Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21; 4(8):673-84. PMID: 19624097; PMCID: PMC2886514.
      View in: PubMed, PubMed Central
    46. Sigurdson CJ, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A. Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis. 2009 Jan 15; 199(2):243-52. PMID: 19072552; PMCID: PMC2822447.
      View in: PubMed, PubMed Central
    47. Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 2008 Dec 19; 29(6):998-1008. PMID: 19100703.
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    48. Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):304-9. PMID: 19073920; PMCID: PMC2629180.
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    49. Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One. 2008; 3(12):e3872. PMID: 19060956; PMCID: PMC2592702.
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    50. Sigurdson CJ. A prion disease of cervids: chronic wasting disease. Vet Res. 2008 Jul-Aug; 39(4):41. PMID: 18381058.
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    51. Sigurdson CJ, Mathiason CK, Perrott MR, Eliason GA, Spraker TR, Glatzel M, Manco G, Bartz JC, Miller MW, Hoover EA. Experimental chronic wasting disease (CWD) in the ferret. J Comp Pathol. 2008 May; 138(4):189-96. PMID: 18387626.
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    52. Aguzzi A, Sigurdson C, Heikenwaelder M. Molecular mechanisms of prion pathogenesis. Annu Rev Pathol. 2008; 3:11-40. PMID: 18233951.
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    53. Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. Prion strain discrimination using luminescent conjugated polymers. Nat Methods. 2007 Dec; 4(12):1023-30. PMID: 18026110.
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    54. Sigurdson CJ, Aguzzi A. Chronic wasting disease. Biochim Biophys Acta. 2007 Jun; 1772(6):610-8. PMID: 17223321; PMCID: PMC2680674.
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    55. Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hays SA, Hayes-Klug J, Seelig DM, Wild MA, Wolfe LL, Spraker TR, Miller MW, Sigurdson CJ, Telling GC, Hoover EA. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006 Oct 06; 314(5796):133-6. PMID: 17023660.
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    56. Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. Strain fidelity of chronic wasting disease upon murine adaptation. J Virol. 2006 Dec; 80(24):12303-11. PMID: 17020952; PMCID: PMC1676299.
      View in: PubMed, PubMed Central
    57. Angers RC, Browning SR, Seward TS, Sigurdson CJ, Miller MW, Hoover EA, Telling GC. Prions in skeletal muscles of deer with chronic wasting disease. Science. 2006 Feb 24; 311(5764):1117. PMID: 16439622.
      View in: PubMed
    58. Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, Maestrale C, Cancedda MG, Madau L, Aguzzi A. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med. 2005 Nov; 11(11):1137-8. PMID: 16270061.
      View in: PubMed
    59. Sigurdson C, Glatzel M, Aguzzi A. Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy". Vet Pathol. 2005 Jan; 42(1):107. PMID: 15657284.
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