Christina Sigurdson

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular basis of prion protein-induced neurodegeneration
    NIH RF1NS121992Jun 1, 2021 - May 31, 2024
    Role: Principal Investigator
    FASEB SRC on Protein Aggregation, from Structural Variants to in Vivo Sequela
    NIH R13NS111914Jun 1, 2019 - May 31, 2020
    Role: Principal Investigator
    Probing prion clearance through interstitial fluid and perivascular pathways
    NIH R21NS110409Sep 30, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Molecular basis of spongiform encephalopathy in prion disease
    NIH R21NS105498Aug 1, 2018 - Jul 31, 2021
    Role: Principal Investigator
    UCSD Research Training Program for Veterinarians
    NIH T32OD017863May 2, 2014 - Apr 30, 2024
    Role: Principal Investigator
    Mechanisms of Prion Spread
    NIH R01NS076896Sep 15, 2012 - Apr 30, 2022
    Role: Principal Investigator
    Mechanisms of Prion Aggregation
    NIH R01NS069566Mar 15, 2011 - Apr 30, 2026
    Role: Principal Investigator
    Infectious prion generation by mouse transgenesis
    NIH R21NS055116Aug 15, 2007 - Jul 31, 2010
    Role: Principal Investigator
    BRIDGES TO THE BACCALAUREATE PROGRAM AT SAN DIEGO MESA COLLEGE
    NIH R25GM073590Jul 1, 2005 - May 31, 2020
    Role: Co-Principal Investigator
    CWD: ROLE OF THE LYMPHOID TISSUE PHASE IN PRION DISEASE
    NIH K08AI001802Aug 1, 2000 - Jul 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiol Dis. 2022 10 01; 172:105834. Ojeda-Juárez D, Lawrence JA, Soldau K, Pizzo DP, Wheeler E, Aguilar-Calvo P, Khuu H, Chen J, Malik A, Funk G, Nam P, Sanchez H, Geschwind MD, Wu C, Yeo GW, Chen X, Patrick GN, Sigurdson CJ. PMID: 35905927.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Minimal change prion retinopathy: Morphometric comparison of retinal and brain prion deposits in Creutzfeldt-Jakob disease. Exp Eye Res. 2022 09; 222:109172. Goodwill VS, Dryden I, Choi J, De Lillo C, Soldau K, Llibre-Guerra J, Sanchez H, Sigurdson CJ, Lin JH. PMID: 35803332.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system. J Biol Chem. 2022 03; 298(3):101642. Gonias SL, Banki MA, Azmoon P, Romero HK, Sigurdson CJ, Mantuano E, Campana WM. PMID: 35090893; PMCID: PMC8861162.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer. J Alzheimers Dis. 2022; 88(3):1137-1145. Aguilar-Calvo P, Sevillano AM, Rasool S, Cao KJ, Randolph LM, Rissman RA, Sarraf ST, Yang J, Sigurdson CJ. PMID: 35754278.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex. J Immunol. 2022 01 01; 208(1):85-96. Mantuano E, Azmoon P, Banki MA, Sigurdson CJ, Campana WM, Gonias SL. PMID: 34810220; PMCID: PMC8702456.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease. J Biol Chem. 2021 11; 297(5):101267. Liu H, Kim C, Haldiman T, Sigurdson CJ, Nyström S, Nilsson KPR, Cohen ML, Wisniewski T, Hammarström P, Safar JG. PMID: 34599965; PMCID: PMC8531671.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. ARCAM-1 Facilitates Fluorescence Detection of Amyloid-Containing Deposits in the Retina. Transl Vis Sci Technol. 2021 06 01; 10(7):5. Cao KJ, Kim JH, Kroeger H, Gaffney PM, Lin JH, Sigurdson CJ, Yang J. PMID: 34096989; PMCID: PMC8185402.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    8. Scaling analysis reveals the mechanism and rates of prion replication in vivo. Nat Struct Mol Biol. 2021 04; 28(4):365-372. Meisl G, Kurt T, Condado-Morales I, Bett C, Sorce S, Nuvolone M, Michaels TCT, Heinzer D, Avar M, Cohen SIA, Hornemann S, Aguzzi A, Dobson CM, Sigurdson CJ, Knowles TPJ. PMID: 33767451; PMCID: PMC8922999.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    9. Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission. PLoS Pathog. 2021 01; 17(1):e1009123. Aguilar-Calvo P, Callender JA, Sigurdson CJ. PMID: 33444414; PMCID: PMC7808606.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. J Neuropathol Exp Neurol. 2020 11 01; 79(11):1141-1146. Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, Montine TJ, Morgello S, Phelps C, Safar J, Schneider JA, Schonberger LB, Sigurdson C, Silverberg N, Trojanowski JQ, Frosch MP. PMID: 33000167; PMCID: PMC7577514.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    11. A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor. J Biol Chem. 2020 10 09; 295(41):14178-14188. Mantuano E, Azmoon P, Banki MA, Lam MS, Sigurdson CJ, Gonias SL. PMID: 32788217; PMCID: PMC7549038.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease. Neurobiol Dis. 2020 08; 142:104955. Callender JA, Sevillano AM, Soldau K, Kurt TD, Schumann T, Pizzo DP, Altmeppen H, Glatzel M, Esko JD, Sigurdson CJ. PMID: 32454127; PMCID: PMC7425694.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease. J Clin Invest. 2020 03 02; 130(3):1350-1362. Sevillano AM, Aguilar-Calvo P, Kurt TD, Lawrence JA, Soldau K, Nam TH, Schumann T, Pizzo DP, Nyström S, Choudhury B, Altmeppen H, Esko JD, Glatzel M, Nilsson KPR, Sigurdson CJ. PMID: 31985492; PMCID: PMC7269597.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    14. Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions. Acta Neuropathol. 2020 03; 139(3):527-546. Aguilar-Calvo P, Sevillano AM, Bapat J, Soldau K, Sandoval DR, Altmeppen HC, Linsenmeier L, Pizzo DP, Geschwind MD, Sanchez H, Appleby BS, Cohen ML, Safar JG, Edland SD, Glatzel M, Nilsson KPR, Esko JD, Sigurdson CJ. PMID: 31673874; PMCID: PMC7036335.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    15. Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun. 2019 10 29; 10(1):4760. Kollmer M, Close W, Funk L, Rasmussen J, Bsoul A, Schierhorn A, Schmidt M, Sigurdson CJ, Jucker M, Fändrich M. PMID: 31664019; PMCID: PMC6820800.
      View in: PubMed   Mentions: 153     Fields:    Translation:Humans
    16. Recent advances on the molecular pathogenesis of prion diseases. Brain Pathol. 2019 03; 29(2):245-247. Glatzel M, Sigurdson CJ. PMID: 30588674; PMCID: PMC8028283.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease. Acta Neuropathol. 2019 04; 137(4):585-598. Kraus A, Saijo E, Metrick MA, Newell K, Sigurdson CJ, Zanusso G, Ghetti B, Caughey B. PMID: 30570675; PMCID: PMC6426988.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    18. Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients. mBio. 2018 11 20; 9(6). Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ. PMID: 30459197; PMCID: PMC6247090.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    19. Cellular and Molecular Mechanisms of Prion Disease. Annu Rev Pathol. 2019 01 24; 14:497-516. Sigurdson CJ, Bartz JC, Glatzel M. PMID: 30355150; PMCID: PMC9071098.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    20. Generation of novel neuroinvasive prions following intravenous challenge. Brain Pathol. 2018 11; 28(6):999-1011. Aguilar-Calvo P, Bett C, Sevillano AM, Kurt TD, Lawrence J, Soldau K, Hammarström P, Nilsson KPR, Sigurdson CJ. PMID: 29505163; PMCID: PMC6123309.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids. Sci Rep. 2018 05 03; 8(1):6950. Cao KJ, Elbel KM, Cifelli JL, Cirera J, Sigurdson CJ, Paesani F, Theodorakis EA, Yang J. PMID: 29725045; PMCID: PMC5934448.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice. Prion. 2017 11 02; 11(6):431-439. Sikorska B, Gajos A, Bogucki A, Zielonka E, Sigurdson C, Liberski PP. PMID: 29105545; PMCID: PMC5786356.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    23. Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem. 2017 11 17; 292(46):19076-19086. Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ. PMID: 28931606; PMCID: PMC5704488.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 04 21; 5(1):32. Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C, Sigurdson CJ. PMID: 28431576; PMCID: PMC5399838.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    25. Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Sci Rep. 2017 03 08; 7:43295. Aguilar-Calvo P, Xiao X, Bett C, Eraña H, Soldau K, Castilla J, Nilsson KP, Surewicz WK, Sigurdson CJ. PMID: 28272426; PMCID: PMC5341109.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    26. Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines. Pathobiol Aging Age Relat Dis. 2016; 6:32397. Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W. PMID: 27317189; PMCID: PMC4912600.
      View in: PubMed   Mentions: 7  
    27. Polymorphism of Amyloid Fibrils In Vivo. Angew Chem Int Ed Engl. 2016 Apr 04; 55(15):4822-5. Annamalai K, G?hrs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Sch?nland S, F?ndrich M. PMID: 26954430; PMCID: PMC4864496.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    28. Cross-species transmission of CWD prions. Prion. 2016; 10(1):83-91. Kurt TD, Sigurdson CJ. PMID: 26809254; PMCID: PMC4981193.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    29. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Alg?l H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, B?nhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolom? A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, B?dard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, B?nard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, B?ckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouch? M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, B?tikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ce?a V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.
      View in: PubMed   Mentions: 2667     Fields:    Translation:HumansAnimals
    30. Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors. Vet Pathol. 2016 May; 53(3):637-47. Gaffney PM, Witte C, Clifford DL, Imai DM, O'Brien TD, Trejo M, Liberta F, Annamalai K, F?ndrich M, Masliah E, Munson L, Sigurdson CJ. PMID: 26419399; PMCID: PMC4871602.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    31. A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry. 2015 Oct 19; 21(43):15133-7. Shirani H, Linares M, Sigurdson CJ, Lindgren M, Norman P, Nilsson KP. PMID: 26388448; PMCID: PMC4641461.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    32. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. Kurt TD, Jiang L, Fern?ndez-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25961458; PMCID: PMC4497774.
      View in: PubMed   Mentions: 12     Fields:    
    33. Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol. 2015 Jul; 185(7):1800-8. Hiramatsu N, Chiang WC, Kurt TD, Sigurdson CJ, Lin JH. PMID: 25956028; PMCID: PMC4484218.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    34. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96. Kurt TD, Jiang L, Fern?ndez-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25705888; PMCID: PMC4396485.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    35. Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One. 2014; 9(11):e113765. Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C. PMID: 25429466; PMCID: PMC4245998.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J. 2015 Mar; 29(3):911-9. Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E, Sigurdson CJ. PMID: 25422367; PMCID: PMC6137862.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion. 2014; 8(4):319-29. Magnusson K, Simon R, Sj?lander D, Sigurdson CJ, Hammarstr?m P, Nilsson KP. PMID: 25495506; PMCID: PMC4601348.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    38. A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the �2-a2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-10667. Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson CJ. PMID: 24596090; PMCID: PMC4036184.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    39. Prion transmission prevented by modifying the �2-a2 loop structure of host PrPC. J Neurosci. 2014 Jan 15; 34(3):1022-7. Kurt TD, Bett C, Fern?ndez-Borges N, Joshi-Barr S, Hornemann S, R?licke T, Castilla J, W?thrich K, Aguzzi A, Sigurdson CJ. PMID: 24431459; PMCID: PMC3891945.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    40. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb; 88(4):2071-82. Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson CJ. PMID: 24307586; PMCID: PMC3911572.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates. Chemistry. 2013 Jul 29; 19(31):10179-92. Klingstedt T, Shirani H, ?slund KO, Cairns NJ, Sigurdson CJ, Goedert M, Nilsson KP. PMID: 23780508; PMCID: PMC3884759.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    42. Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS Pathog. 2013; 9(4):e1003280. Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB, Sigurdson CJ. PMID: 23637596; PMCID: PMC3630170.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    43. Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb; 94(Pt 2):432-442. Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. PMID: 23100363; PMCID: PMC3709615.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsPHPublic Health
    44. Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-� and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41. Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis EA, Yang J. PMID: 22866977; PMCID: PMC3480552.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS One. 2012; 7(6):e39055. Mitchell GB, Sigurdson CJ, O'Rourke KI, Algire J, Harrington NP, Walther I, Spraker TR, Balachandran A. PMID: 22723928; PMCID: PMC3377593.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    46. Structure of the �2-a2 loop and interspecies prion transmission. FASEB J. 2012 Jul; 26(7):2868-76. Bett C, Fern?ndez-Borges N, Kurt TD, Lucero M, Nilsson KP, Castilla J, Sigurdson CJ. PMID: 22490928; PMCID: PMC3382101.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    47. Prion infection promotes extensive accumulation of a-synuclein in aged human a-synuclein transgenic mice. Prion. 2012 Apr-Jun; 6(2):184-90. Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M, Sigurdson CJ. PMID: 22460692; PMCID: PMC3366356.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    48. PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP. PLoS Pathog. 2012; 8(3):e1002547. Sajnani G, Silva CJ, Ramos A, Pastrana MA, Onisko BC, Erickson ML, Antaki EM, Dynin I, V?zquez-Fern?ndez E, Sigurdson CJ, Carter JM, Requena JR. PMID: 22396643; PMCID: PMC3291653.
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    49. Biochemical properties of highly neuroinvasive prion strains. PLoS Pathog. 2012 Feb; 8(2):e1002522. Bett C, Joshi-Barr S, Lucero M, Trejo M, Liberski P, Kelly JW, Masliah E, Sigurdson CJ. PMID: 22319450; PMCID: PMC3271082.
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    50. Spongiform encephalopathy in transgenic mice expressing a point mutation in the �2-a2 loop of the prion protein. J Neurosci. 2011 Sep 28; 31(39):13840-7. Sigurdson CJ, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, R?licke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, W?thrich K, Aguzzi A. PMID: 21957246; PMCID: PMC3205959.
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    51. Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets. J Gen Virol. 2012 Jan; 93(Pt 1):212-221. Perrott MR, Sigurdson CJ, Mason GL, Hoover EA. PMID: 21918005; PMCID: PMC3352335.
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    52. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255. Chang WM, Dakanali M, Capule CC, Sigurdson CJ, Yang J, Theodorakis EA. PMID: 21743829; PMCID: PMC3129977.
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    53. Tracking protein aggregate interactions. Prion. 2011 Apr-Jun; 5(2):52-5. Sigurdson CJ, Bartz JC, Nilsson KP. PMID: 21597336; PMCID: PMC3166500.
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    54. Sheep with scrapie and mastitis transmit infectious prions through the milk. J Virol. 2011 Jan; 85(2):1136-9. Ligios C, Cancedda MG, Carta A, Santucciu C, Maestrale C, Demontis F, Saba M, Patta C, DeMartini JC, Aguzzi A, Sigurdson CJ. PMID: 21084475; PMCID: PMC3020009.
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    55. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol. 2010 12; 6(12):702-6. Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. PMID: 21045796; PMCID: PMC4996353.
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    56. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24. Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. PMID: 20695487; PMCID: PMC2996463.
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    57. Prion strain interactions are highly selective. J Neurosci. 2010 Sep 08; 30(36):12094-102. Nilsson KP, Joshi-Barr S, Winson O, Sigurdson CJ. PMID: 20826672; PMCID: PMC2951977.
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    58. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010 Oct; 91(Pt 10):2651-7. Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. PMID: 20610667; PMCID: PMC3052602.
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    59. A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest. 2010 Jul; 120(7):2590-9. Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Fern?ndez-Borges N, Schwarz P, Castilla J, W?thrich K, Aguzzi A. PMID: 20551516; PMCID: PMC2898603.
      View in: PubMed   Mentions: 70     Fields:    Translation:Animals
    60. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21; 4(8):673-84. Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. PMID: 19624097; PMCID: PMC2886514.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    61. Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis. 2009 Jan 15; 199(2):243-52. Sigurdson CJ, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A. PMID: 19072552; PMCID: PMC2822447.
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    62. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 2008 Dec 19; 29(6):998-1008. Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A. PMID: 19100703.
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    63. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):304-9. Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. PMID: 19073920; PMCID: PMC2629180.
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    64. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One. 2008; 3(12):e3872. Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A. PMID: 19060956; PMCID: PMC2592702.
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    65. A prion disease of cervids: chronic wasting disease. Vet Res. 2008 Jul-Aug; 39(4):41. Sigurdson CJ. PMID: 18381058.
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    66. Experimental chronic wasting disease (CWD) in the ferret. J Comp Pathol. 2008 May; 138(4):189-96. Sigurdson CJ, Mathiason CK, Perrott MR, Eliason GA, Spraker TR, Glatzel M, Manco G, Bartz JC, Miller MW, Hoover EA. PMID: 18387626.
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    67. Molecular mechanisms of prion pathogenesis. Annu Rev Pathol. 2008; 3:11-40. Aguzzi A, Sigurdson C, Heikenwaelder M. PMID: 18233951.
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    68. Prion strain discrimination using luminescent conjugated polymers. Nat Methods. 2007 Dec; 4(12):1023-30. Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. PMID: 18026110.
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    69. Chronic wasting disease. Biochim Biophys Acta. 2007 Jun; 1772(6):610-8. Sigurdson CJ, Aguzzi A. PMID: 17223321; PMCID: PMC2680674.
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    70. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006 Oct 06; 314(5796):133-6. Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hays SA, Hayes-Klug J, Seelig DM, Wild MA, Wolfe LL, Spraker TR, Miller MW, Sigurdson CJ, Telling GC, Hoover EA. PMID: 17023660.
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    71. Strain fidelity of chronic wasting disease upon murine adaptation. J Virol. 2006 Dec; 80(24):12303-11. Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. PMID: 17020952; PMCID: PMC1676299.
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    72. Prions in skeletal muscles of deer with chronic wasting disease. Science. 2006 Feb 24; 311(5764):1117. Angers RC, Browning SR, Seward TS, Sigurdson CJ, Miller MW, Hoover EA, Telling GC. PMID: 16439622.
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    73. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med. 2005 Nov; 11(11):1137-8. Ligios C, Sigurdson CJ, Santucciu C, Carcassola G, Manco G, Basagni M, Maestrale C, Cancedda MG, Madau L, Aguzzi A. PMID: 16270061.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    74. Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy". Vet Pathol. 2005 Jan; 42(1):107. Sigurdson C, Glatzel M, Aguzzi A. PMID: 15657284.
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    75. Reconstructing prions: fibril assembly from simple yeast to complex mammals. Neurodegener Dis. 2005; 2(1):1-5. Sigurdson C, Polymenidou M, Aguzzi A. PMID: 16908997.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    76. Antiprion immunotherapy: to suppress or to stimulate? Nat Rev Immunol. 2004 Sep; 4(9):725-36. Aguzzi A, Sigurdson CJ. PMID: 15343371.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    77. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med. 2004 Feb; 10(2):187-92. Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A. PMID: 14745443.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    78. Other animal prion diseases. Br Med Bull. 2003; 66:199-212. Sigurdson CJ, Miller MW. PMID: 14522860.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    79. PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer. J Gen Virol. 2002 Oct; 83(Pt 10):2617-2628. Sigurdson CJ, Barillas-Mury C, Miller MW, Oesch B, van Keulen LJM, Langeveld JPM, Hoover EA. PMID: 12237446.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    80. Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy. J Gen Virol. 2002 Oct; 83(Pt 10):2629-2634. Wild MA, Spraker TR, Sigurdson CJ, O'Rourke KI, Miller MW. PMID: 12237447.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    81. Distribution of protease-resistant prion protein and spongiform encephalopathy in free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease. Vet Pathol. 2002 Sep; 39(5):546-56. Spraker TR, Zink RR, Cummings BA, Sigurdson CJ, Miller MW, O'Rourke KI. PMID: 12243464.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    82. Globoid cell-like leukodystrophy in a domestic longhaired cat. Vet Pathol. 2002 Jul; 39(4):494-6. Sigurdson CJ, Basaraba RJ, Mazzaferro EM, Gould DH. PMID: 12126153.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    83. PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease. J Gen Virol. 2001 Oct; 82(Pt 10):2327-2334. Sigurdson CJ, Spraker TR, Miller MW, Oesch B, Hoover EA. PMID: 11562526.
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    84. Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol. 1999 Oct; 80 ( Pt 10):2757-2764. Sigurdson CJ, Williams ES, Miller MW, Spraker TR, O'Rourke KI, Hoover EA. PMID: 10573172.
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    85. Association of excess sulfur intake and an increase in hydrogen sulfide concentrations in the ruminal gas cap of recently weaned beef calves with polioencephalomalacia. J Am Vet Med Assoc. 1998 Dec 01; 213(11):1599-604, 1571. Loneragan GH, Gould DH, Callan RJ, Sigurdson CJ, Hamar DW. PMID: 9838961.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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