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Yitzhak Tor

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0358
La Jolla CA 92093
Phone858-534-6401
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    Collapse Research 
    Collapse Research Activities and Funding
    Cellular uptake of glycoside-based transporters
    NIH/NIGMS R01GM077471May 1, 2007 - Feb 28, 2011
    Role: Principal Investigator
    Fluorescent Nucleosides and Oligonucleotides
    NIH/NIGMS R01GM069773Jan 1, 2004 - Apr 30, 2021
    Role: Principal Investigator
    Novel Approaches to the Discovery of Anti-HIV Agents
    NIH/NIAID R01AI047673May 1, 2000 - Apr 30, 2009
    Role: Principal Investigator
    METAL CONTAINING DNA--SYNTHESIS AND PROPERTIES
    NIH/NIGMS R01GM058447Feb 1, 1999 - Jul 31, 2003
    Role: Principal Investigator
    MODIFIED AMINOGLYCOSIDE AMTIBIOTICS AS ANTIHIV DRUGS
    NIH/NIAID R21AI040315Sep 30, 1997 - Sep 29, 1998
    Role: Principal Investigator
    Peptidomimetic Opioids, Synthesis, Structure &Biology
    NIH/NIDA R01DA005539Jul 1, 1990 - Aug 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ejlersen M, Lou C, Sanghvi YS, Tor Y, Wengel J. Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions. Chem Commun (Camb). 2018 Jul 12; 54(57):8003-8006. PMID: 29967912.
      View in: PubMed
    2. Naini SMA, Yanicostas C, Hassan-Abdi R, Blondeel S, Bennis M, Weiss RJ, Tor Y, Esko JD, Soussi-Yanicostas N. Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy. Transl Neurodegener. 2018; 7:6. PMID: 29568517.
      View in: PubMed
    3. Hallé F, Fin A, Rovira AR, Tor Y. Emissive Synthetic Cofactors: Enzymatic Interconversions of tz A Analogues of ATP, NAD+ , NADH, NADP+ , and NADPH. Angew Chem Int Ed Engl. 2018 Jan 22; 57(4):1087-1090. PMID: 29228460.
      View in: PubMed
    4. Hadidi K, Wexselblatt E, Esko JD, Tor Y. Cellular uptake of modified aminoglycosides. J Antibiot (Tokyo). 2017 Nov 01. PMID: 29089598.
      View in: PubMed
    5. Rovira AR, Fin A, Tor Y. Emissive Synthetic Cofactors: An Isomorphic, Isofunctional, and Responsive NAD+ Analogue. J Am Chem Soc. 2017 11 08; 139(44):15556-15559. PMID: 29043790.
      View in: PubMed
    6. Liu W, Shin D, Ng M, Sanbonmatsu KY, Tor Y, Cooperman BS. Stringent Nucleotide Recognition by the Ribosome at the Middle Codon Position. Molecules. 2017 Aug 29; 22(9). PMID: 28850078.
      View in: PubMed
    7. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Dec 06; 25(12):2743-2752. PMID: 28958576.
      View in: PubMed
    8. Rovira AR, Tor Y. Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides. J Antibiot (Tokyo). 2018 Feb; 71(2):342-344. PMID: 28743975.
      View in: PubMed
    9. Yaakov N, Chaikin Y, Wexselblatt E, Tor Y, Vaskevich A, Rubinstein I. Application of Surface Click Reactions to Localized Surface Plasmon Resonance (LSPR) Biosensing. Chemistry. 2017 Jul 26; 23(42):10148-10155. PMID: 28556288.
      View in: PubMed
    10. Weiss RJ, Esko JD, Tor Y. Targeting heparin and heparan sulfate protein interactions. Org Biomol Chem. 2017 Jul 21; 15(27):5656-5668. PMID: 28653068.
      View in: PubMed
    11. Kilin V, Gavvala K, Barthes NP, Michel BY, Shin D, Boudier C, Mauffret O, Yashchuk V, Mousli M, Ruff M, Granger F, Eiler S, Bronner C, Tor Y, Burger A, Mély Y. Dynamics of Methylated Cytosine Flipping by UHRF1. J Am Chem Soc. 2017 02 15; 139(6):2520-2528. PMID: 28112929.
      View in: PubMed
    12. Rovira AR, Fin A, Tor Y. Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. Chem Sci. 2017 Apr 01; 8(4):2983-2993. PMID: 28451365.
      View in: PubMed
    13. Hopkins PA, McCoy LS, Tor Y. Enzymatic incorporation and utilization of an emissive 6-azauridine. Org Biomol Chem. 2017 Jan 18; 15(3):684-690. PMID: 27981333.
      View in: PubMed
    14. Hamill KM, Wexselblatt E, Tong W, Esko JD, Tor Y. Delivery of Cargo to Lysosomes Using GNeosomes. Methods Mol Biol. 2017; 1594:151-163. PMID: 28456981.
      View in: PubMed
    15. Li Y, Fin A, McCoy L, Tor Y. Polymerase-Mediated Site-Specific Incorporation of a Synthetic Fluorescent Isomorphic G Surrogate into RNA. Angew Chem Int Ed Engl. 2017 Jan 24; 56(5):1303-1307. PMID: 28000329.
      View in: PubMed
    16. Sganappa A, Wexselblatt E, Bellucci MC, Esko JD, Tedeschi G, Tor Y, Volonterio A. Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules. Chembiochem. 2017 Jan 03; 18(1):119-125. PMID: 27806190.
      View in: PubMed
    17. Sholokh M, Improta R, Mori M, Sharma R, Kenfack C, Shin D, Voltz K, Stote RH, Zaporozhets OA, Botta M, Tor Y, Mély Y. Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels. Angew Chem Int Ed Engl. 2016 Jul 04; 55(28):7974-7978. PMID: 27273741; PMCID: PMC4978544 [Available on 01/04/17].
    18. Freeman NS, Moore CE, Wilhelmsson LM, Tor Y. Chromophoric Nucleoside Analogues: Synthesis and Characterization of 6-Aminouracil-Based Nucleodyes. J Org Chem. 2016 06 03; 81(11):4530-9. PMID: 27128151.
      View in: PubMed
    19. Hamill KM, McCoy LS, Wexselblatt E, Esko JD, Tor Y. Polymyxins Facilitate Entry into Mammalian Cells. Chem Sci. 2016 Aug 01; 7(8):5059-5068. PMID: 28044098.
      View in: PubMed
    20. Kong B, Joshi T, Belousoff MJ, Tor Y, Graham B, Spiccia L. Neomycin B-cyclen conjugates and their Zn(II) complexes as RNA-binding agents. J Inorg Biochem. 2016 09; 162:334-342. PMID: 26786595.
      View in: PubMed
    21. Rovira AR, Fin A, Tor Y. Chemical Mutagenesis of an Emissive RNA Alphabet. J Am Chem Soc. 2015 Nov 25; 137(46):14602-5. PMID: 26523462.
      View in: PubMed
    22. Weiss RJ, Gordts PL, Le D, Xu D, Esko JD, Tor Y. Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. PMID: 28133533.
      View in: PubMed
    23. Mizrahi RA, Shin D, Sinkeldam RW, Phelps KJ, Fin A, Tantillo DJ, Tor Y, Beal PA. A Fluorescent Adenosine Analogue as a Substrate for an A-to-I RNA Editing Enzyme. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8713-6. PMID: 26095193; PMCID: PMC4532316.
    24. Wexselblatt E, Esko JD, Tor Y. GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery. ACS Nano. 2015; 9(4):3961-8. PMID: 25831231.
      View in: PubMed
    25. Sholokh M, Sharma R, Shin D, Das R, Zaporozhets OA, Tor Y, Mély Y. Conquering 2-aminopurine's deficiencies: highly emissive isomorphic guanosine surrogate faithfully monitors guanosine conformation and dynamics in DNA. J Am Chem Soc. 2015 Mar 11; 137(9):3185-8. PMID: 25714036; PMCID: PMC4357565.
    26. Rios AC, Yu HT, Tor Y. Hydrolytic Fitness of N-glycosyl Bonds: Comparing the Deglycosylation Kinetics of Modified, Alternative and Native Nucleosides. J Phys Org Chem. 2015 Mar; 28(3):173-180. PMID: 25750482.
      View in: PubMed
    27. Shin D, Lönn P, Dowdy SF, Tor Y. Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates. Chem Commun (Camb). 2015 Jan 31; 51(9):1662-5. PMID: 25500944; PMCID: PMC4298453.
    28. McCoy LS, Shin D, Tor Y. Isomorphic emissive GTP surrogate facilitates initiation and elongation of in vitro transcription reactions. J Am Chem Soc. 2014 Oct 29; 136(43):15176-84. PMID: 25255464; PMCID: PMC4227834.
    29. Hopkins PA, Sinkeldam RW, Tor Y. Visibly emissive and responsive extended 6-aza-uridines. Org Lett. 2014 Oct 17; 16(20):5290-3. PMID: 25285451; PMCID: PMC4201329.
    30. Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem. 2014; 6:25-64. PMID: 25232278; PMCID: PMC4159373.
    31. Fair RJ, McCoy LS, Hensler ME, Aguilar B, Nizet V, Tor Y. Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria. ChemMedChem. 2014 Sep; 9(9):2164-71. PMID: 25055981; PMCID: PMC4298452.
    32. Wexselblatt E, Esko JD, Tor Y. On guanidinium and cellular uptake. J Org Chem. 2014 Aug 01; 79(15):6766-74. PMID: 25019333; PMCID: PMC4120969.
    33. Müller UF, Tor Y. Citric acid and the RNA world. Angew Chem Int Ed Engl. 2014 May 19; 53(21):5245-7. PMID: 24828228; PMCID: PMC4357230.
    34. Inoue M, Wexselblatt E, Esko JD, Tor Y. Macromolecular uptake of alkyl-chain-modified guanidinoglycoside molecular transporters. Chembiochem. 2014 Mar 21; 15(5):676-80. PMID: 24677320; PMCID: PMC4216228.
    35. Lane RS, Jones R, Sinkeldam RW, Tor Y, Magennis SW. Two-photon-induced fluorescence of isomorphic nucleobase analogs. Chemphyschem. 2014 Apr 04; 15(5):867-71. PMID: 24604669; PMCID: PMC4041282.
    36. Sinkeldam RW, McCoy LS, Shin D, Tor Y. Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue. Angew Chem Int Ed Engl. 2013 Dec 23; 52(52):14026-30. PMID: 24288262; PMCID: PMC3947497.
    37. McCoy LS, Roberts KD, Nation RL, Thompson PE, Velkov T, Li J, Tor Y. Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro. Chembiochem. 2013 Nov 04; 14(16):2083-6. PMID: 24105917; PMCID: PMC3947458.
    38. Peters JP, Yelgaonkar SP, Srivatsan SG, Tor Y, James Maher L. Mechanical properties of DNA-like polymers. Nucleic Acids Res. 2013 Dec; 41(22):10593-604. PMID: 24013560; PMCID: PMC3905893.
    39. Noé MS, Sinkeldam RW, Tor Y. Oligodeoxynucleotides containing multiple thiophene-modified isomorphic fluorescent nucleosides. J Org Chem. 2013 Aug 16; 78(16):8123-8. PMID: 23859712; PMCID: PMC3799853.
    40. Liu W, Shin D, Tor Y, Cooperman BS. Monitoring translation with modified mRNAs strategically labeled with isomorphic fluorescent guanosine mimetics. ACS Chem Biol. 2013 Sep 20; 8(9):2017-23. PMID: 23865809; PMCID: PMC3783585.
    41. Rios AC, Tor Y. On the Origin of the Canonical Nucleobases: An Assessment of Selection Pressures across Chemical and Early Biological Evolution. Isr J Chem. 2013 Jun; 53(6-7):469-483. PMID: 25284884.
      View in: PubMed
    42. Inoue M, Tong W, Esko JD, Tor Y. Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol. 2013 Jul 19; 8(7):1383-8. PMID: 23621420; PMCID: PMC3773245.
    43. Frolov L, Dix A, Tor Y, Tesler AB, Chaikin Y, Vaskevich A, Rubinstein I. Direct observation of aminoglycoside-RNA binding by localized surface plasmon resonance spectroscopy. Anal Chem. 2013 Feb 19; 85(4):2200-7. PMID: 23368968; PMCID: PMC3581361.
    44. Rios AC, Tor Y. Refining the genetic alphabet: a late-period selection pressure? Astrobiology. 2012 Sep; 12(9):884-91. PMID: 22984873; PMCID: PMC3444765.
    45. Sinkeldam RW, Hopkins PA, Tor Y. Modified 6-aza uridines: highly emissive pH-sensitive fluorescent nucleosides. Chemphyschem. 2012 Oct 08; 13(14):3350-6. PMID: 22777983; PMCID: PMC3466602.
    46. Noé MS, Ríos AC, Tor Y. Design, synthesis, and spectroscopic properties of extended and fused pyrrolo-dC and pyrrolo-C analogs. Org Lett. 2012 Jun 15; 14(12):3150-3. PMID: 22646728; PMCID: PMC3426657.
    47. Fair RJ, Hensler ME, Thienphrapa W, Dam QN, Nizet V, Tor Y. Selectively guanidinylated aminoglycosides as antibiotics. ChemMedChem. 2012 Jul; 7(7):1237-44. PMID: 22639134; PMCID: PMC3383777.
    48. Wanunu M, Bhattacharya S, Xie Y, Tor Y, Aksimentiev A, Drndic M. Nanopore analysis of individual RNA/antibiotic complexes. ACS Nano. 2011 Dec 27; 5(12):9345-53. PMID: 22067050; PMCID: PMC3253136.
    49. Shin D, Sinkeldam RW, Tor Y. Emissive RNA alphabet. J Am Chem Soc. 2011 Sep 28; 133(38):14912-5. PMID: 21866967; PMCID: PMC3179766.
    50. Sinkeldam RW, Marcus P, Uchenik D, Tor Y. Multisensing emissive pyrimidine. Chemphyschem. 2011 Aug 22; 12(12):2260-5. PMID: 21698743; PMCID: PMC3365504.
    51. Shukla GC, Haque F, Tor Y, Wilhelmsson LM, Toulmé JJ, Isambert H, Guo P, Rossi JJ, Tenenbaum SA, Shapiro BA. A boost for the emerging field of RNA nanotechnology. ACS Nano. 2011 May 24; 5(5):3405-18. PMID: 21604810; PMCID: PMC3102291.
    52. Shin D, Tor Y. Bifacial nucleoside as a surrogate for both T and A in duplex DNA. J Am Chem Soc. 2011 May 11; 133(18):6926-9. PMID: 21495708; PMCID: PMC3093761.
    53. Sinkeldam RW, Wheat AJ, Boyaci H, Tor Y. Emissive nucleosides as molecular rotors. Chemphyschem. 2011 Feb 25; 12(3):567-70. PMID: 21344595; PMCID: PMC3102795.
    54. McCoy LS, Xie Y, Tor Y. Antibiotics that target protein synthesis. Wiley Interdiscip Rev RNA. 2011 Mar-Apr; 2(2):209-32. PMID: 21957007.
      View in: PubMed
    55. Dix AV, Fischer L, Sarrazin S, Redgate CP, Esko JD, Tor Y. Cooperative, heparan sulfate-dependent cellular uptake of dimeric guanidinoglycosides. Chembiochem. 2010 Nov 02; 11(16):2302-10. PMID: 20931643; PMCID: PMC2997625.
    56. Xie Y, Maxson T, Tor Y. Fluorescent nucleoside analogue displays enhanced emission upon pairing with guanine. Org Biomol Chem. 2010 Nov 21; 8(22):5053-5. PMID: 20862439; PMCID: PMC3032630.
    57. Xie Y, Maxson T, Tor Y. Fluorescent ribonucleoside as a FRET acceptor for tryptophan in native proteins. J Am Chem Soc. 2010 Sep 01; 132(34):11896-7. PMID: 20690779; PMCID: PMC2941768.
    58. Xie Y, Dix AV, Tor Y. Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites. Chem Commun (Camb). 2010 Aug 14; 46(30):5542-4. PMID: 20464029; PMCID: PMC3035430.
    59. Sinkeldam RW, Greco NJ, Tor Y. Fluorescent analogs of biomolecular building blocks: design, properties, and applications. Chem Rev. 2010 May 12; 110(5):2579-619. PMID: 20205430; PMCID: PMC2868948.
    60. Sarrazin S, Wilson B, Sly WS, Tor Y, Esko JD. Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes. Mol Ther. 2010 Jul; 18(7):1268-74. PMID: 20442709; PMCID: PMC2911259.
    61. Xie Y, Dix AV, Tor Y. FRET enabled real time detection of RNA-small molecule binding. J Am Chem Soc. 2009 Dec 09; 131(48):17605-14. PMID: 19908830; PMCID: PMC3031783.
    62. Rios AC, Tor Y. Model systems: how chemical biologists study RNA. Curr Opin Chem Biol. 2009 Dec; 13(5-6):660-8. PMID: 19879179; PMCID: PMC2787688.
    63. Greco NJ, Sinkeldam RW, Tor Y. An emissive C analog distinguishes between G, 8-oxoG, and T. Org Lett. 2009 Mar 05; 11(5):1115-8. PMID: 19196162; PMCID: PMC2765557.
    64. Srivatsan SG, Tor Y. Enzymatic incorporation of emissive pyrimidine ribonucleotides. Chem Asian J. 2009 Mar 02; 4(3):419-27. PMID: 19072942.
      View in: PubMed
    65. Belousoff MJ, Ung P, Forsyth CM, Tor Y, Spiccia L, Graham B. New macrocyclic terbium(III) complex for use in RNA footprinting experiments. J Am Chem Soc. 2009 Jan 28; 131(3):1106-14. PMID: 19119812; PMCID: PMC2633772.
    66. Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK, Esko JD. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. J Biol Chem. 2009 Feb 20; 284(8):4952-9. PMID: 19106107.
      View in: PubMed
    67. Belousoff MJ, Gasser G, Graham B, Tor Y, Spiccia L. Binding of HIV-1 TAR mRNA to a peptide nucleic acid oligomer and its conjugates with metal-ion-binding multidentate ligands. J Biol Inorg Chem. 2009 Feb; 14(2):287-300. PMID: 19015900.
      View in: PubMed
    68. Belousoff MJ, Graham B, Spiccia L, Tor Y. Cleavage of RNA oligonucleotides by aminoglycosides. Org Biomol Chem. 2009 Jan 07; 7(1):30-3. PMID: 19081939.
      View in: PubMed
    69. Schuksz M, Fuster MM, Brown JR, Crawford BE, Ditto DP, Lawrence R, Glass CA, Wang L, Tor Y, Esko JD. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13075-80. PMID: 18725627.
      View in: PubMed
    70. Sinkeldam RW, Greco NJ, Tor Y. Polarity of major grooves explored by using an isosteric emissive nucleoside. Chembiochem. 2008 Mar 25; 9(5):706-9. PMID: 18286575.
      View in: PubMed
    71. Srivatsan SG, Weizman H, Tor Y. A highly fluorescent nucleoside analog based on thieno[3,4-d]pyrimidine senses mismatched pairing. Org Biomol Chem. 2008 Apr 21; 6(8):1334-8. PMID: 18385838.
      View in: PubMed
    72. Staple DW, Venditti V, Niccolai N, Elson-Schwab L, Tor Y, Butcher SE. Guanidinoneomycin B recognition of an HIV-1 RNA helix. Chembiochem. 2008 Jan 04; 9(1):93-102. PMID: 18058789; PMCID: PMC2782590.
    73. Srivatsan SG, Greco NJ, Tor Y. A highly emissive fluorescent nucleoside that signals the activity of toxic ribosome-inactivating proteins. Angew Chem Int Ed Engl. 2008; 47(35):6661-5. PMID: 18683267; PMCID: PMC2633406.
    74. Sinkeldam RW, Tor Y. To D or not to D? On estimating the microenvironment polarity of biomolecular cavities. Org Biomol Chem. 2007 Aug 21; 5(16):2523-8. PMID: 18019524.
      View in: PubMed
    75. Glazer EC, Magde D, Tor Y. Ruthenium complexes that break the rules: structural features controlling dual emission. J Am Chem Soc. 2007 Jul 11; 129(27):8544-51. PMID: 17571887; PMCID: PMC2518632.
    76. Greco NJ, Tor Y. Furan Decorated Nucleoside Analogues as Fluorescent Probes: synthesis, photophysical evaluation and site-specific incorporation. Tetrahedron. 2007 Apr 23; 63(17):3515-3527. PMID: 18431439.
      View in: PubMed
    77. Srivatsan SG, Tor Y. Using an emissive uridine analogue for assembling fluorescent HIV-1 TAR constructs. Tetrahedron. 2007 Apr 23; 63(17):3601-3607. PMID: 18431440.
      View in: PubMed
    78. Barbieri CM, Kaul M, Bozza-Hingos M, Zhao F, Tor Y, Hermann T, Pilch DS. Defining the molecular forces that determine the impact of neomycin on bacterial protein synthesis: importance of the 2'-amino functionality. Antimicrob Agents Chemother. 2007 May; 51(5):1760-9. PMID: 17353247; PMCID: PMC1855527.
    79. Tam VK, Kwong D, Tor Y. Fluorescent HIV-1 Dimerization Initiation Site: design, properties, and use for ligand discovery. J Am Chem Soc. 2007 Mar 21; 129(11):3257-66. PMID: 17319662; PMCID: PMC2525870.
    80. Elson-Schwab L, Garner OB, Schuksz M, Crawford BE, Esko JD, Tor Y. Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway. J Biol Chem. 2007 May 04; 282(18):13585-91. PMID: 17311923.
      View in: PubMed
    81. Srivatsan SG, Tor Y. Fluorescent pyrimidine ribonucleotide: synthesis, enzymatic incorporation, and utilization. J Am Chem Soc. 2007 Feb 21; 129(7):2044-53. PMID: 17256858; PMCID: PMC2517582.
    82. Greco NJ, Tor Y. Synthesis and site-specific incorporation of a simple fluorescent pyrimidine. Nat Protoc. 2007; 2(2):305-16. PMID: 17406590.
      View in: PubMed
    83. Srivatsan SG, Tor Y. Synthesis and enzymatic incorporation of a fluorescent pyrimidine ribonucleotide. Nat Protoc. 2007; 2(6):1547-55. PMID: 17571062.
      View in: PubMed
    84. Yu DH, Macdonald J, Josephs S, Liu Q, Nguy V, Tor Y, Wong-Staal F, Li QX. MDDD, a 4,9-diazapyrenium derivative, is selectively toxic to glioma cells by inducing growth arrest at G0/G1 independently of p53. Invest New Drugs. 2006 Nov; 24(6):489-98. PMID: 16633716.
      View in: PubMed
    85. Blount KF, Tor Y. A tale of two targets: differential RNA selectivity of nucleobase-aminoglycoside conjugates. Chembiochem. 2006 Oct; 7(10):1612-21. PMID: 16915600.
      View in: PubMed
    86. Yang G, Trylska J, Tor Y, McCammon JA. Binding of aminoglycosidic antibiotics to the oligonucleotide A-site model and 30S ribosomal subunit: Poisson-Boltzmann model, thermal denaturation, and fluorescence studies. J Med Chem. 2006 Sep 07; 49(18):5478-90. PMID: 16942021.
      View in: PubMed
    87. Talley TT, Yalda S, Ho KY, Tor Y, Soti FS, Kem WR, Taylor P. Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions. Biochemistry. 2006 Jul 25; 45(29):8894-902. PMID: 16846232; PMCID: PMC3222595.
    88. Jaramillo D, Wheate NJ, Ralph SF, Howard WA, Tor Y, Aldrich-Wright JR. Polyamide platinum anticancer complexes designed to target specific DNA sequences. Inorg Chem. 2006 Jul 24; 45(15):6004-13. PMID: 16842007.
      View in: PubMed
    89. Tam VK, Liu Q, Tor Y. Extended ethidium bromide analogue as a triple helix intercalator: synthesis, photophysical properties and nucleic acids binding. Chem Commun (Camb). 2006 Jul 05; (25):2684-6. PMID: 16786087.
      View in: PubMed
    90. Jouvenot D, Glazer EC, Tor Y. Photodimerizable ditopic ligand. Org Lett. 2006 May 11; 8(10):1987-90. PMID: 16671763; PMCID: PMC2517581.
    91. Greco NJ, Hysell M, Goldenberg JR, Rheingold AL, Tor Y. Alkyne-containing chelating ligands: synthesis, properties and metal coordination of 1,2-di(quinolin-8-yl)ethyne. Dalton Trans. 2006 May 21; (19):2288-90. PMID: 16688316.
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    92. Tor Y. The ribosomal A-site as an inspiration for the design of RNA binders. Biochimie. 2006 Aug; 88(8):1045-51. PMID: 16581175.
      View in: PubMed
    93. Zhao F, Zhao Q, Blount KF, Han Q, Tor Y, Hermann T. Molecular recognition of RNA by neomycin and a restricted neomycin derivative. Angew Chem Int Ed Engl. 2005 Aug 19; 44(33):5329-34. PMID: 16037995.
      View in: PubMed
    94. Greco NJ, Tor Y. Simple fluorescent pyrimidine analogues detect the presence of DNA abasic sites. J Am Chem Soc. 2005 Aug 10; 127(31):10784-5. PMID: 16076156.
      View in: PubMed
    95. Hysell M, Siegel JS, Tor Y. Synthesis and stability of exocyclic triazine nucleosides. Org Biomol Chem. 2005 Aug 21; 3(16):2946-52. PMID: 16186926.
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    96. Blount KF, Zhao F, Hermann T, Tor Y. Conformational constraint as a means for understanding RNA-aminoglycoside specificity. J Am Chem Soc. 2005 Jul 13; 127(27):9818-29. PMID: 15998086.
      View in: PubMed
    97. Siegel JS, Tor Y. Genetic alphabetic order: what came before A? Org Biomol Chem. 2005 May 07; 3(9):1591-2. PMID: 15858634.
      View in: PubMed
    98. Glazer EC, Magde D, Tor Y. Dual emission from a family of conjugated dinuclear Ru(II) complexes. J Am Chem Soc. 2005 Mar 30; 127(12):4190-2. PMID: 15783199.
      View in: PubMed
    99. Boer J, Blount KF, Luedtke NW, Elson-Schwab L, Tor Y. RNA-selective modification by a platinum(II) complex conjugated to amino- and guanidinoglycosides. Angew Chem Int Ed Engl. 2005 Jan 28; 44(6):927-32. PMID: 15630712.
      View in: PubMed
    100. Luedtke NW, Liu Q, Tor Y. On the electronic structure of ethidium. Chemistry. 2005 Jan 07; 11(2):495-508. PMID: 15549769.
      View in: PubMed
    101. Jaramillo D, Liu Q, Aldrich-Wright J, Tor Y. Synthesis of N-methylpyrrole and N-methylimidazole amino acids suitable for solid-phase synthesis. J Org Chem. 2004 Nov 12; 69(23):8151-3. PMID: 15527311.
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    102. Aldrich-Wright J, Brodie C, Glazer EC, Luedtke NW, Elson-Schwab L, Tor Y. Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+. Chem Commun (Camb). 2004 Apr 21; (8):1018-9. PMID: 15069523.
      View in: PubMed
    103. Luedtke NW, Liu Q, Tor Y. Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives based on ethidium. Bioorg Med Chem. 2003 Nov 17; 11(23):5235-47. PMID: 14604688.
      View in: PubMed
    104. Luedtke NW, Carmichael P, Tor Y. Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine. J Am Chem Soc. 2003 Oct 15; 125(41):12374-5. PMID: 14531657.
      View in: PubMed
    105. Luedtke NW, Liu Q, Tor Y. RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element. Biochemistry. 2003 Oct 07; 42(39):11391-403. PMID: 14516190.
      View in: PubMed
    106. Tor Y. Targeting RNA with small molecules. Chembiochem. 2003 Oct 06; 4(10):998-1007. PMID: 14523917.
      View in: PubMed
    107. Blount KF, Tor Y. Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding. Nucleic Acids Res. 2003 Oct 01; 31(19):5490-500. PMID: 14500811; PMCID: PMC206455.
    108. Luedtke NW, Hwang JS, Nava E, Gut D, Kol M, Tor Y. The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium bromide. Nucleic Acids Res. 2003 Oct 01; 31(19):5732-40. PMID: 14500837; PMCID: PMC206458.
    109. Luedtke NW, Tor Y. Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors. Biopolymers. 2003 Sep; 70(1):103-19. PMID: 12925996.
      View in: PubMed
    110. Liu Q, Tor Y. Simple conversion of aromatic amines into azides. Org Lett. 2003 Jul 10; 5(14):2571-2. PMID: 12841783.
      View in: PubMed
    111. Fineberg K, Fineberg T, Graessmann A, Luedtke NW, Tor Y, Lixin R, Jans DA, Loyter A. Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules. Biochemistry. 2003 Mar 11; 42(9):2625-33. PMID: 12614157.
      View in: PubMed
    112. Hurley DJ, Tor Y. Donor/acceptor interactions in systematically modified Ru(II)-Os(II) oligonucleotides. J Am Chem Soc. 2002 Nov 06; 124(44):13231-41. PMID: 12405852.
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    113. Glazer EC, Tor Y. RuII complexes of "large-surface" ligands. Angew Chem Int Ed Engl. 2002 Nov 04; 41(21):4022-6. PMID: 12412069.
      View in: PubMed
    114. Luedtke NW, Hwang JS, Glazer EC, Gut D, Kol M, Tor Y. Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA. Chembiochem. 2002 Aug 02; 3(8):766-71. PMID: 12203975.
      View in: PubMed
    115. Hurley DJ, Seaman SE, Mazura JC, Tor Y. Fluorescent 1,10-phenanthroline-containing oligonucleotides distinguish between perfect and mismatched base pairing. Org Lett. 2002 Jul 11; 4(14):2305-8. PMID: 12098233.
      View in: PubMed
    116. Hurley DJ, Tor Y. Ru(II) and Os(II) nucleosides and oligonucleotides: synthesis and properties. J Am Chem Soc. 2002 Apr 10; 124(14):3749-62. PMID: 11929265.
      View in: PubMed
    117. Weizman H, Tor Y. Redox-active metal-containing nucleotides: synthesis, tunability, and enzymatic incorporation into DNA. J Am Chem Soc. 2002 Feb 27; 124(8):1568-9. PMID: 11853418.
      View in: PubMed
    118. Tor Y. RNA and the Small Molecule World. Angew Chem Int Ed Engl. 1999 Jun 01; 38(11):1579-1582. PMID: 29710996.
      View in: PubMed
    119. Tor Y, Hermann T, Westhof E. Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme. Chem Biol. 1998 Nov; 5(11):R277-83. PMID: 9831530.
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