Yitzhak Tor

Title(s)Professor, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Fluorescent nucleosides, nucleotides and oligonucleotides
    NIH R35GM139407Feb 1, 2021 - Jan 31, 2026
    Role: Principal Investigator
    Cellular uptake of glycoside-based transporters
    NIH R01GM077471May 1, 2007 - Feb 28, 2011
    Role: Principal Investigator
    Fluorescent Nucleosides and Oligonucleotides
    NIH R01GM069773Jan 1, 2004 - Apr 30, 2021
    Role: Principal Investigator
    Novel Approaches to the Discovery of Anti-HIV Agents
    NIH R01AI047673May 1, 2000 - Apr 30, 2009
    Role: Principal Investigator
    METAL CONTAINING DNA--SYNTHESIS AND PROPERTIES
    NIH R01GM058447Feb 1, 1999 - Jul 31, 2003
    Role: Principal Investigator
    MODIFIED AMINOGLYCOSIDE AMTIBIOTICS AS ANTIHIV DRUGS
    NIH R21AI040315Sep 30, 1997 - Sep 29, 1998
    Role: Principal Investigator
    Peptidomimetic Opioids, Synthesis, Structure &Biology
    NIH R01DA005539Jul 1, 1990 - Aug 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Emissive Alkylated Guanine Analogs as Probes for Monitoring O6-Alkylguanine-DNA-transferase Activity. ACS Omega. 2024 Aug 27; 9(34):36778-36786. Steinbuch KB, Bucardo M, Tor Y. PMID: 39220506; PMCID: PMC11360037.
      View in: PubMed   Mentions:
    2. Emissive Guanosine Analog Applicable for Real-Time Live Cell Imaging. ACS Chem Biol. 2024 Aug 05. Steinbuch KB, Cong D, Rodriguez AJ, Tor Y. PMID: 39101365.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Isomorphic Fluorescent Nucleosides. Acc Chem Res. 2024 05 07; 57(9):1325-1335. Tor Y. PMID: 38613490; PMCID: PMC11079976.
      View in: PubMed   Mentions: 2     Fields:    
    4. Site-specific RNA modification via initiation of in vitro transcription reactions with m6A and isomorphic emissive adenosine analogs. RSC Chem Biol. 2024 May 08; 5(5):454-458. Cong D, Steinbuch KB, Koyama R, Lam TV, Lam JY, Tor Y. PMID: 38725913; PMCID: PMC11078205.
      View in: PubMed   Mentions:
    5. Inherently Emissive Puromycin Analogues for Live Cell Labelling. Angew Chem Int Ed Engl. 2023 06 05; 62(23):e202216784. Hadidi K, Steinbuch KB, Dozier LE, Patrick GN, Tor Y. PMID: 36973168; PMCID: PMC10213139.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Isomorphic Fluorescent Nucleosides Facilitate Real-Time Monitoring of RNA Depurination by Ribosome Inactivating Proteins. Chemistry. 2022 Jun 21; 28(35):e202200994. Cong D, Li Y, Ludford PT, Tor Y. PMID: 35390188; PMCID: PMC9233005.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    7. Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat Chem Biol. 2022 May; 18(5):575. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. PMID: 35354934.
      View in: PubMed   Mentions:    Fields:    
    8. Azetidines-Containing Fluorescent Purine Analogs: Synthesis and Photophysical Properties. Chemistry. 2022 May 25; 28(30):e202200765. Hadidi K, Tor Y. PMID: 35303392; PMCID: PMC9133108.
      View in: PubMed   Mentions: 2     Fields:    
    9. A New Variant of Emissive RNA Alphabets. Chemistry. 2022 Mar 01; 28(13):e202104472. Ludford PT, Yang S, Bucardo MS, Tor Y. PMID: 35018663; PMCID: PMC8891053.
      View in: PubMed   Mentions: 4     Fields:    
    10. Guanidinoneomycin-maleimide molecular transporter: synthesis, chemistry and cellular uptake. Org Biomol Chem. 2021 Jul 28; 19(29):6513-6520. Hadidi K, Bellucci MC, Dall'Angelo S, Leeson-Payne A, Rochford JJ, Esko JD, Tor Y, Volonterio A. PMID: 34254106.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Cytidine deaminase can deaminate fused pyrimidine ribonucleosides. Org Biomol Chem. 2021 Jul 21; 19(28):6237-6243. Ludford PT, Li Y, Yang S, Tor Y. PMID: 34019616; PMCID: PMC8295196.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    12. Real-Time Monitoring of Human Guanine Deaminase Activity by an Emissive Guanine Analog. ACS Chem Biol. 2021 07 16; 16(7):1208-1214. Bucardo MS, Wu Y, Ludford PT, Li Y, Fin A, Tor Y. PMID: 34190533; PMCID: PMC9109600.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat Chem Biol. 2021 06; 17(6):684-692. Weiss RJ, Spahn PN, Chiang AWT, Liu Q, Li J, Hamill KM, Rother S, Clausen TM, Hoeksema MA, Timm BM, Godula K, Glass CK, Tor Y, Gordts PLSM, Lewis NE, Esko JD. PMID: 33846619; PMCID: PMC8159865.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    14. Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening. ChemMedChem. 2020 11 18; 15(22):2151-2156. Adamek RN, Ludford P, Duggan SM, Tor Y, Cohen SM. PMID: 32729197; PMCID: PMC7815202.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis. Chembiochem. 2020 09 14; 21(18):2595-2598. Li Y, Fin A, Rovira AR, Su Y, Dippel AB, Valderrama JA, Riestra AM, Nizet V, Hammond MC, Tor Y. PMID: 32346955; PMCID: PMC7494572.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    16. Ascertaining the activity and inhibition of adenosine deaminase via fluorescence-based assays. Methods Enzymol. 2020; 639:71-90. Ludford PT, Tor Y. PMID: 32475413.
      View in: PubMed   Mentions: 1     Fields:    
    17. Enzymatic Syntheses and Applications of Fluorescent Cyclic Dinucleotides. Chemistry. 2020 May 12; 26(27):6076-6084. Li Y, Ludford PT, Fin A, Rovira AR, Tor Y. PMID: 32157755; PMCID: PMC7220823.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    18. Emissive Synthetic Cofactors: A Highly Responsive NAD+ Analogue Reveals Biomolecular Recognition Features. Chemistry. 2019 Mar 21; 25(17):4379-4389. Feldmann J, Li Y, Tor Y. PMID: 30648291; PMCID: PMC6944523.
      View in: PubMed   Mentions: 5     Fields:    
    19. Fluorescing Isofunctional Ribonucleosides: Assessing Adenosine Deaminase Activity and Inhibition. Chembiochem. 2019 03 01; 20(5):718-726. Ludford PT, Rovira AR, Fin A, Tor Y. PMID: 30566279; PMCID: PMC6467514.
      View in: PubMed   Mentions: 5     Fields:    
    20. Emissive Synthetic Cofactors: Enzymatic Interconversions of tz A Analogues of ATP, NAD+ , NADH, NADP+ , and NADPH. Angew Chem Int Ed Engl. 2018 01 22; 57(4):1087-1090. Hallé F, Fin A, Rovira AR, Tor Y. PMID: 29228460; PMCID: PMC5771816.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    21. Cellular uptake of modified aminoglycosides. J Antibiot (Tokyo). 2017 Nov 01. Hadidi K, Wexselblatt E, Esko JD, Tor Y. PMID: 29089598.
      View in: PubMed   Mentions:    Fields:    
    22. Emissive Synthetic Cofactors: An Isomorphic, Isofunctional, and Responsive NAD+ Analogue. J Am Chem Soc. 2017 11 08; 139(44):15556-15559. Rovira AR, Fin A, Tor Y. PMID: 29043790; PMCID: PMC5766281.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    23. Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Mol Ther. 2017 Dec 06; 25(12):2743-2752. Tong W, Dwyer CA, Thacker BE, Glass CA, Brown JR, Hamill K, Moremen KW, Sarrazin S, Gordts PLSM, Dozier LE, Patrick GN, Tor Y, Esko JD. PMID: 28958576; PMCID: PMC5768556.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. Synthesis of unique spirocyclic orthoester-type derivatives of isothiazolo[4,3-d]pyrimidine nucleosides. J Antibiot (Tokyo). 2018 02; 71(2):342-344. Rovira AR, Tor Y. PMID: 28743975; PMCID: PMC5785548.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    25. Targeting heparin and heparan sulfate protein interactions. Org Biomol Chem. 2017 Jul 21; 15(27):5656-5668. Weiss RJ, Esko JD, Tor Y. PMID: 28653068; PMCID: PMC5567684.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    26. Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. Chem Sci. 2017 Apr 01; 8(4):2983-2993. Rovira AR, Fin A, Tor Y. PMID: 28451365; PMCID: PMC5380116.
      View in: PubMed   Mentions: 16  
    27. Enzymatic incorporation and utilization of an emissive 6-azauridine. Org Biomol Chem. 2017 Jan 18; 15(3):684-690. Hopkins PA, McCoy LS, Tor Y. PMID: 27981333; PMCID: PMC5243813.
      View in: PubMed   Mentions: 2     Fields:    
    28. Delivery of Cargo to Lysosomes Using GNeosomes. Methods Mol Biol. 2017; 1594:151-163. Hamill KM, Wexselblatt E, Tong W, Esko JD, Tor Y. PMID: 28456981.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    29. Polymerase-Mediated Site-Specific Incorporation of a Synthetic Fluorescent Isomorphic G Surrogate into RNA. Angew Chem Int Ed Engl. 2017 01 24; 56(5):1303-1307. Li Y, Fin A, McCoy L, Tor Y. PMID: 28000329; PMCID: PMC5241218.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    30. Delivery of an active lysosomal enzyme using GNeosomes. J Mater Chem B. 2016 Sep 21; 4(35):5794-5797. Hamill KM, Wexselblatt E, Tong W, Esko JD, Tor Y. PMID: 32263750.
      View in: PubMed   Mentions: 3     Fields:    
    31. Chromophoric Nucleoside Analogues: Synthesis and Characterization of 6-Aminouracil-Based Nucleodyes. J Org Chem. 2016 06 03; 81(11):4530-9. Freeman NS, Moore CE, Wilhelmsson LM, Tor Y. PMID: 27128151; PMCID: PMC5493935.
      View in: PubMed   Mentions: 1     Fields:    
    32. Polymyxins Facilitate Entry into Mammalian Cells. Chem Sci. 2016 Aug 01; 7(8):5059-5068. Hamill KM, McCoy LS, Wexselblatt E, Esko JD, Tor Y. PMID: 28044098; PMCID: PMC5201209.
      View in: PubMed   Mentions: 3  
    33. Chemical Mutagenesis of an Emissive RNA Alphabet. J Am Chem Soc. 2015 Nov 25; 137(46):14602-5. Rovira AR, Fin A, Tor Y. PMID: 26523462; PMCID: PMC5281058.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    34. Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions. Chem Sci. 2015 Oct 01; 6(10):5984-5993. Weiss RJ, Gordts PL, Le D, Xu D, Esko JD, Tor Y. PMID: 28133533; PMCID: PMC5267326.
      View in: PubMed   Mentions: 12  
    35. GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery. ACS Nano. 2015; 9(4):3961-8. Wexselblatt E, Esko JD, Tor Y. PMID: 25831231.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    36. Hydrolytic Fitness of N-glycosyl Bonds: Comparing the Deglycosylation Kinetics of Modified, Alternative and Native Nucleosides. J Phys Org Chem. 2015 Mar; 28(3):173-180. Rios AC, Yu HT, Tor Y. PMID: 25750482; PMCID: PMC4349208.
      View in: PubMed   Mentions: 12  
    37. Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates. Chem Commun (Camb). 2015 Jan 31; 51(9):1662-5. Shin D, Lönn P, Dowdy SF, Tor Y. PMID: 25500944; PMCID: PMC4298453.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    38. Isomorphic emissive GTP surrogate facilitates initiation and elongation of in vitro transcription reactions. J Am Chem Soc. 2014 Oct 29; 136(43):15176-84. McCoy LS, Shin D, Tor Y. PMID: 25255464; PMCID: PMC4227834.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    39. Visibly emissive and responsive extended 6-aza-uridines. Org Lett. 2014 Oct 17; 16(20):5290-3. Hopkins PA, Sinkeldam RW, Tor Y. PMID: 25285451; PMCID: PMC4201329.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    40. Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria. ChemMedChem. 2014 Sep; 9(9):2164-71. Fair RJ, McCoy LS, Hensler ME, Aguilar B, Nizet V, Tor Y. PMID: 25055981; PMCID: PMC4298452.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    41. On guanidinium and cellular uptake. J Org Chem. 2014 Aug 01; 79(15):6766-74. Wexselblatt E, Esko JD, Tor Y. PMID: 25019333; PMCID: PMC4120969.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    42. Citric acid and the RNA world. Angew Chem Int Ed Engl. 2014 May 19; 53(21):5245-7. Müller UF, Tor Y. PMID: 24828228; PMCID: PMC4357230.
      View in: PubMed   Mentions: 1     Fields:    
    43. Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue. Angew Chem Int Ed Engl. 2013 Dec 23; 52(52):14026-30. Sinkeldam RW, McCoy LS, Shin D, Tor Y. PMID: 24288262; PMCID: PMC3947497.
      View in: PubMed   Mentions: 15     Fields:    
    44. Activity of the HMGB1-derived immunostimulatory peptide Hp91 resides in the helical C-terminal portion and is enhanced by dimerization. Mol Immunol. 2014 Feb; 57(2):191-9. Saenz R, Messmer B, Futalan D, Tor Y, Larsson M, Daniels G, Esener S, Messmer D. PMID: 24172222; PMCID: PMC4520421.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    45. Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro. Chembiochem. 2013 Nov 04; 14(16):2083-6. McCoy LS, Roberts KD, Nation RL, Thompson PE, Velkov T, Li J, Tor Y. PMID: 24105917; PMCID: PMC3947458.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    46. Mechanical properties of DNA-like polymers. Nucleic Acids Res. 2013 Dec; 41(22):10593-604. Peters JP, Yelgaonkar SP, Srivatsan SG, Tor Y, James Maher L. PMID: 24013560; PMCID: PMC3905893.
      View in: PubMed   Mentions: 18     Fields:    
    47. Oligodeoxynucleotides containing multiple thiophene-modified isomorphic fluorescent nucleosides. J Org Chem. 2013 Aug 16; 78(16):8123-8. Noé MS, Sinkeldam RW, Tor Y. PMID: 23859712; PMCID: PMC3799853.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    48. On the Origin of the Canonical Nucleobases: An Assessment of Selection Pressures across Chemical and Early Biological Evolution. Isr J Chem. 2013 Jun; 53(6-7):469-483. Rios AC, Tor Y. PMID: 25284884; PMCID: PMC4181368.
      View in: PubMed   Mentions: 25  
    49. Aggregation-mediated macromolecular uptake by a molecular transporter. ACS Chem Biol. 2013 Jul 19; 8(7):1383-8. Inoue M, Tong W, Esko JD, Tor Y. PMID: 23621420; PMCID: PMC3773245.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    50. Refining the genetic alphabet: a late-period selection pressure? Astrobiology. 2012 Sep; 12(9):884-91. Rios AC, Tor Y. PMID: 22984873; PMCID: PMC3444765.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    51. Modified 6-aza uridines: highly emissive pH-sensitive fluorescent nucleosides. Chemphyschem. 2012 Oct 08; 13(14):3350-6. Sinkeldam RW, Hopkins PA, Tor Y. PMID: 22777983; PMCID: PMC3466602.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    52. Design, synthesis, and spectroscopic properties of extended and fused pyrrolo-dC and pyrrolo-C analogs. Org Lett. 2012 Jun 15; 14(12):3150-3. Noé MS, Ríos AC, Tor Y. PMID: 22646728; PMCID: PMC3426657.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    53. Selectively guanidinylated aminoglycosides as antibiotics. ChemMedChem. 2012 Jul; 7(7):1237-44. Fair RJ, Hensler ME, Thienphrapa W, Dam QN, Nizet V, Tor Y. PMID: 22639134; PMCID: PMC3383777.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    54. Emissive RNA alphabet. J Am Chem Soc. 2011 Sep 28; 133(38):14912-5. Shin D, Sinkeldam RW, Tor Y. PMID: 21866967; PMCID: PMC3179766.
      View in: PubMed   Mentions: 67     Fields:    Translation:Cells
    55. Multisensing emissive pyrimidine. Chemphyschem. 2011 Aug 22; 12(12):2260-5. Sinkeldam RW, Marcus P, Uchenik D, Tor Y. PMID: 21698743; PMCID: PMC3365504.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    56. Bifacial nucleoside as a surrogate for both T and A in duplex DNA. J Am Chem Soc. 2011 May 11; 133(18):6926-9. Shin D, Tor Y. PMID: 21495708; PMCID: PMC3093761.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    57. Emissive nucleosides as molecular rotors. Chemphyschem. 2011 Feb 25; 12(3):567-70. Sinkeldam RW, Wheat AJ, Boyaci H, Tor Y. PMID: 21344595; PMCID: PMC3102795.
      View in: PubMed   Mentions: 22     Fields:    
    58. Antibiotics that target protein synthesis. Wiley Interdiscip Rev RNA. 2011 Mar-Apr; 2(2):209-32. McCoy LS, Xie Y, Tor Y. PMID: 21957007.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    59. Cooperative, heparan sulfate-dependent cellular uptake of dimeric guanidinoglycosides. Chembiochem. 2010 Nov 02; 11(16):2302-10. Dix AV, Fischer L, Sarrazin S, Redgate CP, Esko JD, Tor Y. PMID: 20931643; PMCID: PMC2997625.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    60. Fluorescent nucleoside analogue displays enhanced emission upon pairing with guanine. Org Biomol Chem. 2010 Nov 21; 8(22):5053-5. Xie Y, Maxson T, Tor Y. PMID: 20862439; PMCID: PMC3032630.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    61. Fluorescent ribonucleoside as a FRET acceptor for tryptophan in native proteins. J Am Chem Soc. 2010 Sep 01; 132(34):11896-7. Xie Y, Maxson T, Tor Y. PMID: 20690779; PMCID: PMC2941768.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    62. Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites. Chem Commun (Camb). 2010 Aug 14; 46(30):5542-4. Xie Y, Dix AV, Tor Y. PMID: 20464029; PMCID: PMC3035430.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    63. Fluorescent analogs of biomolecular building blocks: design, properties, and applications. Chem Rev. 2010 May 12; 110(5):2579-619. Sinkeldam RW, Greco NJ, Tor Y. PMID: 20205430; PMCID: PMC2868948.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimals
    64. Guanidinylated neomycin mediates heparan sulfate-dependent transport of active enzymes to lysosomes. Mol Ther. 2010 Jul; 18(7):1268-74. Sarrazin S, Wilson B, Sly WS, Tor Y, Esko JD. PMID: 20442709; PMCID: PMC2911259.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    65. FRET enabled real time detection of RNA-small molecule binding. J Am Chem Soc. 2009 Dec 09; 131(48):17605-14. Xie Y, Dix AV, Tor Y. PMID: 19908830; PMCID: PMC3031783.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    66. Model systems: how chemical biologists study RNA. Curr Opin Chem Biol. 2009 Dec; 13(5-6):660-8. Rios AC, Tor Y. PMID: 19879179; PMCID: PMC2787688.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    67. An emissive C analog distinguishes between G, 8-oxoG, and T. Org Lett. 2009 Mar 05; 11(5):1115-8. Greco NJ, Sinkeldam RW, Tor Y. PMID: 19196162; PMCID: PMC2765557.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    68. Enzymatic incorporation of emissive pyrimidine ribonucleotides. Chem Asian J. 2009 Mar 02; 4(3):419-27. Srivatsan SG, Tor Y. PMID: 19072942; PMCID: PMC5263221.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    69. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. J Biol Chem. 2009 Feb 20; 284(8):4952-9. Brown JR, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba PK, Esko JD. PMID: 19106107; PMCID: PMC2643505.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    70. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13075-80. Schuksz M, Fuster MM, Brown JR, Crawford BE, Ditto DP, Lawrence R, Glass CA, Wang L, Tor Y, Esko JD. PMID: 18725627; PMCID: PMC2529023.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    71. Polarity of major grooves explored by using an isosteric emissive nucleoside. Chembiochem. 2008 Mar 25; 9(5):706-9. Sinkeldam RW, Greco NJ, Tor Y. PMID: 18286575.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    72. A highly fluorescent nucleoside analog based on thieno[3,4-d]pyrimidine senses mismatched pairing. Org Biomol Chem. 2008 Apr 21; 6(8):1334-8. Srivatsan SG, Weizman H, Tor Y. PMID: 18385838; PMCID: PMC5263222.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    73. A highly emissive fluorescent nucleoside that signals the activity of toxic ribosome-inactivating proteins. Angew Chem Int Ed Engl. 2008; 47(35):6661-5. Srivatsan SG, Greco NJ, Tor Y. PMID: 18683267; PMCID: PMC2633406.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    74. To D or not to D? On estimating the microenvironment polarity of biomolecular cavities. Org Biomol Chem. 2007 Aug 21; 5(16):2523-8. Sinkeldam RW, Tor Y. PMID: 18019524.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    75. Ruthenium complexes that break the rules: structural features controlling dual emission. J Am Chem Soc. 2007 Jul 11; 129(27):8544-51. Glazer EC, Magde D, Tor Y. PMID: 17571887; PMCID: PMC2518632.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    76. Furan Decorated Nucleoside Analogues as Fluorescent Probes: synthesis, photophysical evaluation and site-specific incorporation. Tetrahedron. 2007 Apr 23; 63(17):3515-3527. Greco NJ, Tor Y. PMID: 18431439; PMCID: PMC1868554.
      View in: PubMed   Mentions: 28     Fields:    
    77. Using an emissive uridine analogue for assembling fluorescent HIV-1 TAR constructs. Tetrahedron. 2007 Apr 23; 63(17):3601-3607. Srivatsan SG, Tor Y. PMID: 18431440; PMCID: PMC1994564.
      View in: PubMed   Mentions: 10     Fields:    
    78. Fluorescent HIV-1 Dimerization Initiation Site: design, properties, and use for ligand discovery. J Am Chem Soc. 2007 Mar 21; 129(11):3257-66. Tam VK, Kwong D, Tor Y. PMID: 17319662; PMCID: PMC2525870.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    79. Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway. J Biol Chem. 2007 May 04; 282(18):13585-91. Elson-Schwab L, Garner OB, Schuksz M, Crawford BE, Esko JD, Tor Y. PMID: 17311923.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    80. Fluorescent pyrimidine ribonucleotide: synthesis, enzymatic incorporation, and utilization. J Am Chem Soc. 2007 Feb 21; 129(7):2044-53. Srivatsan SG, Tor Y. PMID: 17256858; PMCID: PMC2517582.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    81. Synthesis and site-specific incorporation of a simple fluorescent pyrimidine. Nat Protoc. 2007; 2(2):305-16. Greco NJ, Tor Y. PMID: 17406590.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    82. Synthesis and enzymatic incorporation of a fluorescent pyrimidine ribonucleotide. Nat Protoc. 2007; 2(6):1547-55. Srivatsan SG, Tor Y. PMID: 17571062.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    83. Binding of aminoglycosidic antibiotics to the oligonucleotide A-site model and 30S ribosomal subunit: Poisson-Boltzmann model, thermal denaturation, and fluorescence studies. J Med Chem. 2006 Sep 07; 49(18):5478-90. Yang G, Trylska J, Tor Y, McCammon JA. PMID: 16942021.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    84. Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions. Biochemistry. 2006 Jul 25; 45(29):8894-902. Talley TT, Yalda S, Ho KY, Tor Y, Soti FS, Kem WR, Taylor P. PMID: 16846232; PMCID: PMC3222595.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    85. Extended ethidium bromide analogue as a triple helix intercalator: synthesis, photophysical properties and nucleic acids binding. Chem Commun (Camb). 2006 Jul 05; (25):2684-6. Tam VK, Liu Q, Tor Y. PMID: 16786087.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    86. Photodimerizable ditopic ligand. Org Lett. 2006 May 11; 8(10):1987-90. Jouvenot D, Glazer EC, Tor Y. PMID: 16671763; PMCID: PMC2517581.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    87. Alkyne-containing chelating ligands: synthesis, properties and metal coordination of 1,2-di(quinolin-8-yl)ethyne. Dalton Trans. 2006 May 21; (19):2288-90. Greco NJ, Hysell M, Goldenberg JR, Rheingold AL, Tor Y. PMID: 16688316.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    88. The ribosomal A-site as an inspiration for the design of RNA binders. Biochimie. 2006 Aug; 88(8):1045-51. Tor Y. PMID: 16581175.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    89. Molecular recognition of RNA by neomycin and a restricted neomycin derivative. Angew Chem Int Ed Engl. 2005 Aug 19; 44(33):5329-34. Zhao F, Zhao Q, Blount KF, Han Q, Tor Y, Hermann T. PMID: 16037995.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    90. Simple fluorescent pyrimidine analogues detect the presence of DNA abasic sites. J Am Chem Soc. 2005 Aug 10; 127(31):10784-5. Greco NJ, Tor Y. PMID: 16076156.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    91. Synthesis and stability of exocyclic triazine nucleosides. Org Biomol Chem. 2005 Aug 21; 3(16):2946-52. Hysell M, Siegel JS, Tor Y. PMID: 16186926.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    92. Conformational constraint as a means for understanding RNA-aminoglycoside specificity. J Am Chem Soc. 2005 Jul 13; 127(27):9818-29. Blount KF, Zhao F, Hermann T, Tor Y. PMID: 15998086.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    93. Dual emission from a family of conjugated dinuclear Ru(II) complexes. J Am Chem Soc. 2005 Mar 30; 127(12):4190-2. Glazer EC, Magde D, Tor Y. PMID: 15783199.
      View in: PubMed   Mentions: 6     Fields:    
    94. RNA-selective modification by a platinum(II) complex conjugated to amino- and guanidinoglycosides. Angew Chem Int Ed Engl. 2005 Jan 28; 44(6):927-32. Boer J, Blount KF, Luedtke NW, Elson-Schwab L, Tor Y. PMID: 15630712.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    95. On the electronic structure of ethidium. Chemistry. 2005 Jan 07; 11(2):495-508. Luedtke NW, Liu Q, Tor Y. PMID: 15549769.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    96. Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives based on ethidium. Bioorg Med Chem. 2003 Nov 17; 11(23):5235-47. Luedtke NW, Liu Q, Tor Y. PMID: 14604688.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    97. Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine. J Am Chem Soc. 2003 Oct 15; 125(41):12374-5. Luedtke NW, Carmichael P, Tor Y. PMID: 14531657.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    98. RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element. Biochemistry. 2003 Oct 07; 42(39):11391-403. Luedtke NW, Liu Q, Tor Y. PMID: 14516190.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    99. Targeting RNA with small molecules. Chembiochem. 2003 Oct 06; 4(10):998-1007. Tor Y. PMID: 14523917.
      View in: PubMed   Mentions: 59     Fields:    
    100. The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium bromide. Nucleic Acids Res. 2003 Oct 01; 31(19):5732-40. Luedtke NW, Hwang JS, Nava E, Gut D, Kol M, Tor Y. PMID: 14500837; PMCID: PMC206458.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    101. Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding. Nucleic Acids Res. 2003 Oct 01; 31(19):5490-500. Blount KF, Tor Y. PMID: 14500811; PMCID: PMC206455.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    102. Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors. Biopolymers. 2003 Sep; 70(1):103-19. Luedtke NW, Tor Y. PMID: 12925996.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    103. Simple conversion of aromatic amines into azides. Org Lett. 2003 Jul 10; 5(14):2571-2. Liu Q, Tor Y. PMID: 12841783.
      View in: PubMed   Mentions: 11     Fields:    
    104. Donor/acceptor interactions in systematically modified Ru(II)-Os(II) oligonucleotides. J Am Chem Soc. 2002 Nov 06; 124(44):13231-41. Hurley DJ, Tor Y. PMID: 12405852.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    105. RuII complexes of "large-surface" ligands. Angew Chem Int Ed Engl. 2002 Nov 04; 41(21):4022-6. Glazer EC, Tor Y. PMID: 12412069.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    106. Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA. Chembiochem. 2002 Aug 02; 3(8):766-71. Luedtke NW, Hwang JS, Glazer EC, Gut D, Kol M, Tor Y. PMID: 12203975.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    107. Fluorescent 1,10-phenanthroline-containing oligonucleotides distinguish between perfect and mismatched base pairing. Org Lett. 2002 Jul 11; 4(14):2305-8. Hurley DJ, Seaman SE, Mazura JC, Tor Y. PMID: 12098233.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    108. Ru(II) and Os(II) nucleosides and oligonucleotides: synthesis and properties. J Am Chem Soc. 2002 Apr 10; 124(14):3749-62. Hurley DJ, Tor Y. PMID: 11929265.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    109. Redox-active metal-containing nucleotides: synthesis, tunability, and enzymatic incorporation into DNA. J Am Chem Soc. 2002 Feb 27; 124(8):1568-9. Weizman H, Tor Y. PMID: 11853418.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    110. 2-Aminopurine as a real-time probe of enzymatic cleavage and inhibition of hammerhead ribozymes. Bioorg Med Chem. 2001 Sep; 9(9):2295-301. Kirk SR, Luedtke NW, Tor Y. PMID: 11553468.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    111. 2,2'-Bipyridine ligandoside: a novel building block for modifying DNA with intra-duplex metal complexes. J Am Chem Soc. 2001 Apr 11; 123(14):3375-6. Weizman H, Tor Y. PMID: 11457077.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    112. Synthesis and anti-HIV activity of guanidinoglycosides. J Org Chem. 2000 Dec 29; 65(26):9054-8. Baker TJ, Luedtke NW, Tor Y, Goodman M. PMID: 11149851.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    113. tRNA(Phe) binds aminoglycoside antibiotics. Bioorg Med Chem. 1999 Sep; 7(9):1979-91. Kirk SR, Tor Y. PMID: 10530947.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    114. Enhanced RNA binding of dimerized aminoglycosides. Bioorg Med Chem. 1999 Jul; 7(7):1361-71. Michael K, Wang H, Tor Y. PMID: 10465410.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    115. RNA and the Small Molecule World. Angew Chem Int Ed Engl. 1999 Jun 01; 38(11):1579-1582. Tor Y. PMID: 29710996.
      View in: PubMed   Mentions: 9     Fields:    
    116. Tobramycin-EDTA conjugate: a noninnocent affinity-cleaving reagent. Bioorg Med Chem Lett. 1998 Dec 15; 8(24):3665-70. Wang H, Tor Y. PMID: 9934492.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    117. Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme. Chem Biol. 1998 Nov; 5(11):R277-83. Tor Y, Hermann T, Westhof E. PMID: 9831530.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
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