Stephen Hedrick

InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0377
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Mutagenic chain reaction-facilitated immunotherapy
    NIH/NIAID R01AI131081Sep 9, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Inflammation, Insulin Resistance, and Foxo factors
    NIH/NIAID R21AI103772Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    A molecular basis for control of T cell memory
    NIH/NIAID R01AI103440Dec 1, 2012 - Nov 30, 2017
    Role: Principal Investigator
    Control of Lymphocyte Homeostasis by Foxo Transcription Factors
    NIH/NIAID R01AI073885May 15, 2009 - Aug 30, 2011
    Role: Principal Investigator
    Training in Immunology
    NIH/NIAID T32AI060536Jul 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Targeted antigens for novel strategies of vaccination
    NIH/NIAID R21AI055845Sep 30, 2003 - Aug 31, 2005
    Role: Principal Investigator
    DRAK2, a kinase that regulates T cell activation
    NIH/NIAID R01AI053091Dec 15, 2002 - Nov 30, 2007
    Role: Principal Investigator
    Protein Carbohydrate Interactions in Cell Communication
    NIH U54GM062116Sep 1, 2000 - Dec 31, 2011
    Role: Co-Investigator
    Genetic Modulation of Blood and Vascular Glycosylation
    NIH/NHLBI P01HL057345Sep 30, 1997 - Dec 31, 2013
    Role: Co-Investigator
    NIH/NCI R01CA076554Jul 1, 1997 - Jun 30, 2001
    Role: Principal Investigator
    Cell Biology and Genetics of T Cell Activation and Death
    NIH/NIAID R01AI037988Jun 1, 1995 - Aug 31, 2016
    Role: Principal Investigator
    NIH/NCI R01CA058319May 1, 1992 - Apr 30, 1994
    Role: Principal Investigator
    NIH/NIAID R01AI029990Apr 1, 1991 - Mar 31, 1994
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    NIH/NIGMS R01GM035880Jul 1, 1985 - Jun 30, 1997
    Role: Principal Investigator
    NIH/NIAID K04AI000662Jul 1, 1985 - Jun 30, 1990
    Role: Principal Investigator
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    The Regulation of T Cell Development
    NIH/NIAID R01AI021372Jul 1, 1984 - Aug 30, 2012
    Role: Principal Investigator
    T Cell Receptor Molecular Structure And Expression
    NIH/NIAID R37AI021372Jul 1, 1984 - Apr 30, 2007
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Utzschneider DT, Delpoux A, Wieland D, Huang X, Lai CY, Hofmann M, Thimme R, Hedrick S. Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1. Cell Rep. 2018 Mar 27; 22(13):3454-3467. PMID: 29590615.
      View in: PubMed
    2. Tsau JS, Huang X, Lai CY, Hedrick S. The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection. J Immunol. 2018 Feb 15; 200(4):1335-1346. PMID: 29311359.
      View in: PubMed
    3. Delpoux A, Michelini RH, Verma S, Lai CY, Omilusik KD, Utzschneider DT, Redwood AJ, Goldrath AW, Benedict CA, Hedrick S. Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells. J Exp Med. 2018 Feb 05; 215(2):575-594. PMID: 29282254.
      View in: PubMed
    4. Delpoux A, Lai CY, Hedrick S, Doedens AL. FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity. Proc Natl Acad Sci U S A. 2017 Oct 17; 114(42):E8865-E8874. PMID: 28973925.
      View in: PubMed
    5. Hedrick S. Understanding Immunity through the Lens of Disease Ecology. Trends Immunol. 2017 Dec; 38(12):888-903. PMID: 28882454.
      View in: PubMed
    6. Morris GP, Hedrick S. A rheostat tuning thymic selection. Nat Immunol. 2017 Jun 20; 18(7):713-714. PMID: 28632719.
      View in: PubMed
    7. Stienne C, Michieletto MF, Benamar M, Carrié N, Bernard I, Nguyen XH, Lippi Y, Duguet F, Liblau RS, Hedrick S, Saoudi A, Dejean AS. Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes. Immunity. 2016 10 18; 45(4):774-787. PMID: 27742544.
      View in: PubMed
    8. Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick S, Glass CK. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. Elife. 2016 07 04; 5. PMID: 27376549; PMCID: PMC4931909.
    9. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick S, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 05 04; 90(3):535-50. PMID: 27112497; PMCID: PMC4860075 [Available on 05/04/17].
    10. Mah IK, Soloff R, Hedrick S, Mariani FV. Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. Stem Cell Reports. 2015 Nov 10; 5(5):866-880. PMID: 26527382; PMCID: PMC4649379.
    11. Kang H, Corr M, Mansson R, Welinder E, Hedrick S, Stone EL. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis. PLoS One. 2015; 10(5):e0126728. PMID: 25969990; PMCID: PMC4430473.
    12. Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Lin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick S. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 2015 Feb 17; 42(2):239-251. PMID: 25692700.
      View in: PubMed
    13. Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick S, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL. Noncanonical mode of ERK action controls alternative aß and ?d T cell lineage fates. Immunity. 2014 Dec 18; 41(6):934-46. PMID: 25526308; PMCID: PMC4273651 [Available on 12/18/15].
    14. Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick S, Pe'er D, Mathis D, Nolan GP, Benoist C. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. PMID: 25362052; PMCID: PMC4246343.
    15. Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK, Hutcheson J, Hedrick S, Mohan C, Budinger GS, Stehlik C, Perlman H. Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. J Immunol. 2014 Jun 15; 192(12):5548-60. PMID: 24808358; PMCID: PMC4074511.
    16. Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick S, Nizet V. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One. 2014; 9(2):e89274. PMID: 24586650; PMCID: PMC3929751.
    17. Hess Michelini R, Doedens AL, Goldrath AW, Hedrick S. Differentiation of CD8 memory T cells depends on Foxo1. J Exp Med. 2013 Jun 03; 210(6):1189-200. PMID: 23712431; PMCID: PMC3674697.
    18. Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick S, Almutairi A. Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integr Biol (Camb). 2013 Jan; 5(1):195-203. PMID: 23060228; PMCID: PMC3535018.
    19. Hedrick S, Hess Michelini R, Doedens AL, Goldrath AW, Stone EL. FOXO transcription factors throughout T cell biology. Nat Rev Immunol. 2012 Sep; 12(9):649-61. PMID: 22918467; PMCID: PMC3875397.
    20. Gu L, Ruff LE, Qin Z, Corr M, Hedrick S, Sailor MJ. Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Adv Mater. 2012 Aug 02; 24(29):3981-7. PMID: 22689074; PMCID: PMC3517000.
    21. Chang CF, D'Souza WN, Ch'en IL, Pages G, Pouyssegur J, Hedrick S. Polar opposites: Erk direction of CD4 T cell subsets. J Immunol. 2012 Jul 15; 189(2):721-31. PMID: 22675204; PMCID: PMC3392534.
    22. Hedrick S. Positive selection in the thymus: an enigma wrapped in a mystery. J Immunol. 2012 Mar 01; 188(5):2043-5. PMID: 22345700; PMCID: PMC3387976.
    23. Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick S, Tenzer S, Neurath MF, Becker C. Caspase-8 regulates TNF-a-induced epithelial necroptosis and terminal ileitis. Nature. 2011 Sep 14; 477(7364):335-9. PMID: 21921917; PMCID: PMC3373730.
    24. Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick S. Mechanisms of necroptosis in T cells. J Exp Med. 2011 Apr 11; 208(4):633-41. PMID: 21402742; PMCID: PMC3135356.
    25. Kerdiles YM, Stone EL, Beisner DR, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick S. Foxo transcription factors control regulatory T cell development and function. Immunity. 2010 Dec 14; 33(6):890-904. PMID: 21167754; PMCID: PMC3034255.
    26. Dejean AS, Hedrick S, Kerdiles YM. Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal. 2011 Feb 15; 14(4):663-74. PMID: 20673126; PMCID: PMC3021368.
    27. Hedrick S, Ch'en IL, Alves BN. Intertwined pathways of programmed cell death in immunity. Immunol Rev. 2010 Jul; 236:41-53. PMID: 20636807; PMCID: PMC3137483.
    28. Soto PC, Stein LL, Hurtado-Ziola N, Hedrick S, Varki A. Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. J Immunol. 2010 Apr 15; 184(8):4185-95. PMID: 20231688; PMCID: PMC3085894.
    29. McGargill MA, Ch'en IL, Katayama CD, Pagès G, Pouysségur J, Hedrick S. Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. J Immunol. 2009 Oct 15; 183(8):4838-42. PMID: 19801509; PMCID: PMC2847885.
    30. Hedrick S. Immune system: not so superior. Science. 2009 Sep 25; 325(5948):1623-4. PMID: 19779174; PMCID: PMC2847887.
    31. Hedrick S. The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol. 2009 Oct; 10(10):1057-63. PMID: 19701188; PMCID: PMC2856448.
    32. Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick S, Richards JS. MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science. 2009 May 15; 324(5929):938-41. PMID: 19443782; PMCID: PMC2847890.
    33. Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick S. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 2009 May; 10(5):504-13. PMID: 19363483; PMCID: PMC2712214.
    34. Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick S. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009 Feb; 10(2):176-84. PMID: 19136962; PMCID: PMC2856471.
    35. McGargill MA, Choy C, Wen BG, Hedrick S. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol. 2008 Dec 01; 181(11):7593-605. PMID: 19017948; PMCID: PMC2792703.
    36. D'Souza WN, Chang CF, Fischer AM, Li M, Hedrick S. The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol. 2008 Dec 01; 181(11):7617-29. PMID: 19017950; PMCID: PMC2847891.
    37. Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick S. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17463-8. PMID: 18981423; PMCID: PMC2582294.
    38. Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick S, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol. 2008 Aug 01; 181(3):2084-91. PMID: 18641347; PMCID: PMC2494872.
    39. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick S, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May; 4(5):313-21. PMID: 18408713.
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    40. Hedrick S. Thymus lineage commitment: a single switch. Immunity. 2008 Mar; 28(3):297-9. PMID: 18342002.
      View in: PubMed
    41. Ch'en IL, Hedrick S, Hoffmann A. NF-kappaB as a determinant of distinct cell death pathways. Methods Enzymol. 2008; 446:175-87. PMID: 18603122.
      View in: PubMed
    42. Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick S, Shokat KM. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 Jun; 4(6):511-6. PMID: 17486086; PMCID: PMC2932705.
    43. Peter ME, Budd RC, Desbarats J, Hedrick S, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH. The CD95 receptor: apoptosis revisited. Cell. 2007 May 04; 129(3):447-50. PMID: 17482535.
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    44. D'Souza WN, Hedrick S. Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol. 2006 Jul 15; 177(2):777-81. PMID: 16818730; PMCID: PMC3137433.
    45. Broussard C, Fleischacker C, Fleischecker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick S, Fowlkes BJ, Schwartzberg PL. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 2006 Jul; 25(1):93-104. PMID: 16860760.
      View in: PubMed
    46. Hedrick S. The TCR of mice and men. J Immunol. 2006 Mar 01; 176(5):2681-2. PMID: 16493021.
      View in: PubMed
    47. Fischer AM, Katayama CD, Pagès G, Pouysségur J, Hedrick S. The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 2005 Oct; 23(4):431-43. PMID: 16226508.
      View in: PubMed
    48. Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick S, Walsh CM. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005 Nov; 17(11):1379-90. PMID: 16172133.
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    49. Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick S. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol. 2005 Sep 15; 175(6):3469-73. PMID: 16148088.
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    50. Hedrick S, Cohen DI, Nielsen EA, Davis MM. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. 1984. J Immunol. 2005 Sep 01; 175(5):2771-5. PMID: 16116160.
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    51. Goldrath AW, Hedrick S. Central tolerance matters. Immunity. 2005 Aug; 23(2):113-4. PMID: 16111630.
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    52. McGargill MA, Sharp LL, Bui JD, Hedrick S, Calbo S. Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling. J Immunol. 2005 Jul 15; 175(2):656-64. PMID: 16002660.
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    53. Catlett IM, Hedrick S. Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells. Nat Immunol. 2005 Jul; 6(7):715-21. PMID: 15924143.
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    54. Lin MY, Zal T, Ch'en IL, Gascoigne NR, Hedrick S. A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol. 2005 May 01; 174(9):5583-92. PMID: 15843557.
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    55. Sato K, Imai Y, Higashi N, Kumamoto Y, Onami TM, Hedrick S, Irimura T. Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Blood. 2005 Jul 01; 106(1):207-15. PMID: 15784728.
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    56. McGargill MA, Wen BG, Walsh CM, Hedrick S. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity. 2004 Dec; 21(6):781-91. PMID: 15589167; PMCID: PMC2792702.
    57. Hedrick S. The acquired immune system: a vantage from beneath. Immunity. 2004 Nov; 21(5):607-15. PMID: 15539148.
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    58. Soloff RS, Katayama C, Lin MY, Feramisco JR, Hedrick S. Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol. 2004 Sep 01; 173(5):3250-60. PMID: 15322187.
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    59. Beisner DR, Chu IH, Arechiga AF, Hedrick S, Walsh CM. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol. 2003 Jul 01; 171(1):247-56. PMID: 12817005.
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    60. Brinkman-Van der Linden EC, Angata T, Reynolds SA, Powell LD, Hedrick S, Varki A. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Mol Cell Biol. 2003 Jun; 23(12):4199-206. PMID: 12773563; PMCID: PMC156146.
    61. Mertsching E, Wurster AL, Katayama C, Esko J, Ramsdell F, Marth JD, Hedrick S. A mouse strain defective for alphabeta versus gammadelta T cell lineage commitment. Int Immunol. 2002 Sep; 14(9):1039-53. PMID: 12202401.
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    62. Onami TM, Lin MY, Page DM, Reynolds SA, Katayama CD, Marth JD, Irimura T, Varki A, Varki N, Hedrick S. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol Cell Biol. 2002 Jul; 22(14):5173-81. PMID: 12077344; PMCID: PMC139776.
    63. Tsuiji M, Fujimori M, Ohashi Y, Higashi N, Onami TM, Hedrick S, Irimura T. Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem. 2002 Aug 09; 277(32):28892-901. PMID: 12016228.
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    64. Hedrick S. T cell development: bottoms-up. Immunity. 2002 May; 16(5):619-22. PMID: 12049714.
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    65. Hedrick S, Sharp LL. T-cell fate. Immunol Rev. 1998 Oct; 165:95-110. PMID: 9850855.
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