Stephen Hedrick

Title(s)Emeritus Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Mutagenic chain reaction-facilitated immunotherapy
    NIH R01AI131081Sep 9, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Inflammation, Insulin Resistance, and Foxo factors
    NIH R21AI103772Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    A molecular basis for control of T cell memory
    NIH R01AI103440Dec 1, 2012 - Nov 30, 2017
    Role: Principal Investigator
    Control of Lymphocyte Homeostasis by Foxo Transcription Factors
    NIH R01AI073885May 15, 2009 - Aug 30, 2011
    Role: Principal Investigator
    Training in Immunology
    NIH T32AI060536Jul 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Targeted antigens for novel strategies of vaccination
    NIH R21AI055845Sep 30, 2003 - Aug 31, 2005
    Role: Principal Investigator
    DRAK2, a kinase that regulates T cell activation
    NIH R01AI053091Dec 15, 2002 - Nov 30, 2007
    Role: Principal Investigator
    Protein Carbohydrate Interactions in Cell Communication
    NIH U54GM062116Sep 1, 2000 - Dec 31, 2011
    Role: Co-Investigator
    Genetic Modulation of Blood and Vascular Glycosylation
    NIH P01HL057345Sep 30, 1997 - Dec 31, 2013
    Role: Co-Investigator
    SCHLAFEN--THE CONTROL OF THYMOCYTE GROWTH &DEVELOPMENT
    NIH R01CA076554Jul 1, 1997 - Jun 30, 2001
    Role: Principal Investigator
    Cell Biology and Genetics of T Cell Activation and Death
    NIH R01AI037988Jun 1, 1995 - Aug 31, 2016
    Role: Principal Investigator
    ECTOPIC EXPRESSION OF THE RETINOBLASTOMA GENE IN MICE
    NIH R01CA058319May 1, 1992 - Apr 30, 1994
    Role: Principal Investigator
    REGULATION OF CD4 GENE EXPRESSION
    NIH R01AI029990Apr 1, 1991 - Mar 31, 1994
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    T-CELL RECOGNITION ANALYZED BY GENE TRANSFECTION
    NIH R01GM035880Jul 1, 1985 - Jun 30, 1997
    Role: Principal Investigator
    THE T-CELL RECEPTOR: MOLECULAR STRUCTURE AND EXPRESSION
    NIH K04AI000662Jul 1, 1985 - Jun 30, 1990
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    The Regulation of T Cell Development
    NIH R01AI021372Jul 1, 1984 - Aug 30, 2012
    Role: Principal Investigator
    T Cell Receptor Molecular Structure And Expression
    NIH R37AI021372Jul 1, 1984 - Apr 30, 2007
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptomes and metabolism define mouse and human MAIT cell populations. Sci Immunol. 2023 11 10; 8(89):eabn8531. Chandra S, Ascui G, Riffelmacher T, Chawla A, Ramírez-Suástegui C, Castelan VC, Seumois G, Simon H, Murray MP, Seo GY, Premlal ALR, Schmiedel B, Verstichel G, Li Y, Lin CH, Greenbaum J, Lamberti J, Murthy R, Nigro J, Cheroutre H, Ottensmeier CH, Hedrick SM, Lu LF, Vijayanand P, Kronenberg M. PMID: 37948512.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation. J Immunol. 2022 09 15; 209(6):1118-1127. Lai CY, Marcel N, Yaldiko AW, Delpoux A, Hedrick SM. PMID: 35948398.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline. PLoS Biol. 2021 Dec; 19(12):e3001478. Weitzel AJ, Grunwald HA, Weber C, Levina R, Gantz VM, Hedrick SM, Bier E, Cooper KL. PMID: 34941868; PMCID: PMC8699911.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    4. Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection. J Exp Med. 2021 08 02; 218(8). Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou MM, Crotty S, Ozato K, Pipkin ME, Goldrath AW. PMID: 34037670; PMCID: PMC8160575.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion. Nat Commun. 2021 05 11; 12(1):2625. Li Z, Marcel N, Devkota S, Auradkar A, Hedrick SM, Gantz VM, Bier E. PMID: 33976171; PMCID: PMC8113449.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. FOXO1 constrains activation and regulates senescence in CD8 T cells. Cell Rep. 2021 01 26; 34(4):108674. Delpoux A, Marcel N, Hess Michelini R, Katayama CD, Allison KA, Glass CK, Quiñones-Parra SM, Murre C, Loh L, Kedzierska K, Lappas M, Hedrick SM, Doedens AL. PMID: 33503413.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    7. Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25667-25678. Milner JJ, Nguyen H, Omilusik K, Reina-Campos M, Tsai M, Toma C, Delpoux A, Boland BS, Hedrick SM, Chang JT, Goldrath AW. PMID: 32978300; PMCID: PMC7568335.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    8. Editorial overview: Lymphocyte effector subsets: blurring the frontiers. Curr Opin Immunol. 2020 04; 63:iii-v. Reynaud CA, Hedrick SM. PMID: 32359520.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. A key control point in the T cell response to chronic infection and neoplasia: FOXO1. Curr Opin Immunol. 2020 04; 63:51-60. Marcel N, Hedrick SM. PMID: 32135399; PMCID: PMC8793964.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. The Imperative to Vaccinate. J Pediatr. 2018 10; 201:259-263. Hedrick SM. PMID: 30054163; PMCID: PMC7131101.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    11. Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1. Cell Rep. 2018 03 27; 22(13):3454-3467. Utzschneider DT, Delpoux A, Wieland D, Huang X, Lai CY, Hofmann M, Thimme R, Hedrick SM. PMID: 29590615; PMCID: PMC5942184.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    12. The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection. J Immunol. 2018 02 15; 200(4):1335-1346. Tsau JS, Huang X, Lai CY, Hedrick SM. PMID: 29311359; PMCID: PMC5863746.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells. J Exp Med. 2018 02 05; 215(2):575-594. Delpoux A, Michelini RH, Verma S, Lai CY, Omilusik KD, Utzschneider DT, Redwood AJ, Goldrath AW, Benedict CA, Hedrick SM. PMID: 29282254; PMCID: PMC5789410.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    14. FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity. Proc Natl Acad Sci U S A. 2017 10 17; 114(42):E8865-E8874. Delpoux A, Lai CY, Hedrick SM, Doedens AL. PMID: 28973925; PMCID: PMC5651728.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    15. Understanding Immunity through the Lens of Disease Ecology. Trends Immunol. 2017 12; 38(12):888-903. Hedrick SM. PMID: 28882454; PMCID: PMC5711578.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    16. A rheostat tuning thymic selection. Nat Immunol. 2017 06 20; 18(7):713-714. Morris GP, Hedrick SM. PMID: 28632719.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    17. Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes. Immunity. 2016 10 18; 45(4):774-787. Stienne C, Michieletto MF, Benamar M, Carrié N, Bernard I, Nguyen XH, Lippi Y, Duguet F, Liblau RS, Hedrick SM, Saoudi A, Dejean AS. PMID: 27742544; PMCID: PMC5141513.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    18. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. Elife. 2016 07 04; 5. Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK. PMID: 27376549; PMCID: PMC4931909.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    19. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 05 04; 90(3):535-50. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. PMID: 27112497; PMCID: PMC4860075.
      View in: PubMed   Mentions: 261     Fields:    Translation:AnimalsCells
    20. Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. Stem Cell Reports. 2015 Nov 10; 5(5):866-880. Mah IK, Soloff R, Hedrick SM, Mariani FV. PMID: 26527382; PMCID: PMC4649379.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    21. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis. PLoS One. 2015; 10(5):e0126728. Kang H, Corr M, Mansson R, Welinder E, Hedrick SM, Stone EL. PMID: 25969990; PMCID: PMC4430473.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 2015 Feb 17; 42(2):239-251. Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Lin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick SM. PMID: 25692700; PMCID: PMC4334393.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    23. Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. Immunity. 2014 Dec 18; 41(6):934-46. Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL. PMID: 25526308; PMCID: PMC4273651.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. PMID: 25362052; PMCID: PMC4246343.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    25. Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. J Immunol. 2014 Jun 15; 192(12):5548-60. Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H. PMID: 24808358; PMCID: PMC4074511.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    26. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One. 2014; 9(2):e89274. Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V. PMID: 24586650; PMCID: PMC3929751.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    27. Differentiation of CD8 memory T cells depends on Foxo1. J Exp Med. 2013 Jun 03; 210(6):1189-200. Hess Michelini R, Doedens AL, Goldrath AW, Hedrick SM. PMID: 23712431; PMCID: PMC3674697.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    28. Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integr Biol (Camb). 2013 Jan; 5(1):195-203. Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick SM, Almutairi A. PMID: 23060228; PMCID: PMC3535018.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. FOXO transcription factors throughout T cell biology. Nat Rev Immunol. 2012 Sep; 12(9):649-61. Hedrick SM, Hess Michelini R, Doedens AL, Goldrath AW, Stone EL. PMID: 22918467; PMCID: PMC3875397.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    30. Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Adv Mater. 2012 Aug 02; 24(29):3981-7. Gu L, Ruff LE, Qin Z, Corr M, Hedrick SM, Sailor MJ. PMID: 22689074; PMCID: PMC3517000.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    31. Polar opposites: Erk direction of CD4 T cell subsets. J Immunol. 2012 Jul 15; 189(2):721-31. Chang CF, D'Souza WN, Ch'en IL, Pages G, Pouyssegur J, Hedrick SM. PMID: 22675204; PMCID: PMC3392534.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    32. Positive selection in the thymus: an enigma wrapped in a mystery. J Immunol. 2012 Mar 01; 188(5):2043-5. Hedrick SM. PMID: 22345700; PMCID: PMC3387976.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    33. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature. 2011 Sep 14; 477(7364):335-9. Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick SM, Tenzer S, Neurath MF, Becker C. PMID: 21921917; PMCID: PMC3373730.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansAnimalsCells
    34. Mechanisms of necroptosis in T cells. J Exp Med. 2011 Apr 11; 208(4):633-41. Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM. PMID: 21402742; PMCID: PMC3135356.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    35. Foxo transcription factors control regulatory T cell development and function. Immunity. 2010 Dec 14; 33(6):890-904. Kerdiles YM, Stone EL, Beisner DR, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM. PMID: 21167754; PMCID: PMC3034255.
      View in: PubMed   Mentions: 237     Fields:    Translation:AnimalsCells
    36. Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal. 2011 Feb 15; 14(4):663-74. Dejean AS, Hedrick SM, Kerdiles YM. PMID: 20673126; PMCID: PMC3021368.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    37. Intertwined pathways of programmed cell death in immunity. Immunol Rev. 2010 Jul; 236:41-53. Hedrick SM, Ch'en IL, Alves BN. PMID: 20636807; PMCID: PMC3137483.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    38. Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. J Immunol. 2010 Apr 15; 184(8):4185-95. Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A. PMID: 20231688; PMCID: PMC3085894.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    39. Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. J Immunol. 2009 Oct 15; 183(8):4838-42. McGargill MA, Ch'en IL, Katayama CD, Pagès G, Pouysségur J, Hedrick SM. PMID: 19801509; PMCID: PMC2847885.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. Immune system: not so superior. Science. 2009 Sep 25; 325(5948):1623-4. Hedrick SM. PMID: 19779174; PMCID: PMC2847887.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    41. The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol. 2009 Oct; 10(10):1057-63. Hedrick SM. PMID: 19701188; PMCID: PMC2856448.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    42. MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science. 2009 May 15; 324(5929):938-41. Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS. PMID: 19443782; PMCID: PMC2847890.
      View in: PubMed   Mentions: 243     Fields:    Translation:AnimalsCells
    43. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 2009 May; 10(5):504-13. Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM. PMID: 19363483; PMCID: PMC2712214.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    44. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009 Feb; 10(2):176-84. Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM. PMID: 19136962; PMCID: PMC2856471.
      View in: PubMed   Mentions: 309     Fields:    Translation:AnimalsCells
    45. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol. 2008 Dec 01; 181(11):7593-605. McGargill MA, Choy C, Wen BG, Hedrick SM. PMID: 19017948; PMCID: PMC2792703.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    46. The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol. 2008 Dec 01; 181(11):7617-29. D'Souza WN, Chang CF, Fischer AM, Li M, Hedrick SM. PMID: 19017950; PMCID: PMC2847891.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    47. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17463-8. Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. PMID: 18981423; PMCID: PMC2582294.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    48. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol. 2008 Aug 01; 181(3):2084-91. Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. PMID: 18641347; PMCID: PMC2494872.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    49. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May; 4(5):313-21. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. PMID: 18408713; PMCID: PMC5434866.
      View in: PubMed   Mentions: 994     Fields:    Translation:Animals
    50. Thymus lineage commitment: a single switch. Immunity. 2008 Mar; 28(3):297-9. Hedrick SM. PMID: 18342002.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    51. NF-kappaB as a determinant of distinct cell death pathways. Methods Enzymol. 2008; 446:175-87. Ch'en IL, Hedrick SM, Hoffmann A. PMID: 18603122.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    52. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 Jun; 4(6):511-6. Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. PMID: 17486086; PMCID: PMC2932705.
      View in: PubMed   Mentions: 171     Fields:    Translation:AnimalsCells
    53. The CD95 receptor: apoptosis revisited. Cell. 2007 May 04; 129(3):447-50. Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH. PMID: 17482535.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimalsCells
    54. Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol. 2006 Jul 15; 177(2):777-81. D'Souza WN, Hedrick SM. PMID: 16818730; PMCID: PMC3137433.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    55. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 2006 Jul; 25(1):93-104. Broussard C, Fleischacker C, Fleischecker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick SM, Fowlkes BJ, Schwartzberg PL. PMID: 16860760.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    56. The TCR of mice and men. J Immunol. 2006 Mar 01; 176(5):2681-2. Hedrick SM. PMID: 16493021.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    57. The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 2005 Oct; 23(4):431-43. Fischer AM, Katayama CD, Pagès G, Pouysségur J, Hedrick SM. PMID: 16226508.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    58. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005 Nov; 17(11):1379-90. Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM. PMID: 16172133.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    59. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol. 2005 Sep 15; 175(6):3469-73. Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM. PMID: 16148088.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    60. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. 1984. J Immunol. 2005 Sep 01; 175(5):2771-5. Hedrick SM, Cohen DI, Nielsen EA, Davis MM. PMID: 16116160.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    61. Central tolerance matters. Immunity. 2005 Aug; 23(2):113-4. Goldrath AW, Hedrick SM. PMID: 16111630.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    62. Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling. J Immunol. 2005 Jul 15; 175(2):656-64. McGargill MA, Sharp LL, Bui JD, Hedrick SM, Calbo S. PMID: 16002660.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    63. Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells. Nat Immunol. 2005 Jul; 6(7):715-21. Catlett IM, Hedrick SM. PMID: 15924143.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    64. A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol. 2005 May 01; 174(9):5583-92. Lin MY, Zal T, Ch'en IL, Gascoigne NR, Hedrick SM. PMID: 15843557.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    65. Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Blood. 2005 Jul 01; 106(1):207-15. Sato K, Imai Y, Higashi N, Kumamoto Y, Onami TM, Hedrick SM, Irimura T. PMID: 15784728.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    66. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity. 2004 Dec; 21(6):781-91. McGargill MA, Wen BG, Walsh CM, Hedrick SM. PMID: 15589167; PMCID: PMC2792702.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    67. The acquired immune system: a vantage from beneath. Immunity. 2004 Nov; 21(5):607-15. Hedrick SM. PMID: 15539148.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    68. Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol. 2004 Sep 01; 173(5):3250-60. Soloff RS, Katayama C, Lin MY, Feramisco JR, Hedrick SM. PMID: 15322187.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    69. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol. 2003 Jul 01; 171(1):247-56. Beisner DR, Chu IH, Arechiga AF, Hedrick SM, Walsh CM. PMID: 12817005.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    70. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Mol Cell Biol. 2003 Jun; 23(12):4199-206. Brinkman-Van der Linden EC, Angata T, Reynolds SA, Powell LD, Hedrick SM, Varki A. PMID: 12773563; PMCID: PMC156146.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    71. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol Cell Biol. 2002 Jul; 22(14):5173-81. Onami TM, Lin MY, Page DM, Reynolds SA, Katayama CD, Marth JD, Irimura T, Varki A, Varki N, Hedrick SM. PMID: 12077344; PMCID: PMC139776.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    72. Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem. 2002 Aug 09; 277(32):28892-901. Tsuiji M, Fujimori M, Ohashi Y, Higashi N, Onami TM, Hedrick SM, Irimura T. PMID: 12016228.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    73. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. PMID: 11557984.
      View in: PubMed   Mentions: 603     Fields:    Translation:HumansAnimalsCells
    74. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat Immunol. 2001 Feb; 2(2):165-71. Bain G, Cravatt CB, Loomans C, Alberola-Ila J, Hedrick SM, Murre C. PMID: 11175815.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    75. Effects of a constitutively active form of calcineurin on T cell activation and thymic selection. J Immunol. 2000 Oct 01; 165(7):3713-21. Hayden-Martinez K, Kane LP, Hedrick SM. PMID: 11034376.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    76. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000 Sep 15; 102(6):753-63. Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, Hedrick SM, Mandel G, Glass CK, Rose DW, Rosenfeld MG. PMID: 11030619.
      View in: PubMed   Mentions: 196     Fields:    Translation:AnimalsCells
    77. A role for CaMKII in T cell memory. Cell. 2000 Feb 18; 100(4):457-67. Bui JD, Calbo S, Hayden-Martinez K, Kane LP, Gardner P, Hedrick SM. PMID: 10693762.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    78. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling. J Immunol. 1999 Dec 15; 163(12):6598-605. Sharp LL, Hedrick SM. PMID: 10586054.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    79. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J Exp Med. 1999 Dec 06; 190(11):1605-16. Bain G, Quong MW, Soloff RS, Hedrick SM, Murre C. PMID: 10587351; PMCID: PMC2195738.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    80. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity. 1998 Nov; 9(5):657-68. Schwarz DA, Katayama CD, Hedrick SM. PMID: 9846487.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    81. T-cell fate. Immunol Rev. 1998 Oct; 165:95-110. Hedrick SM, Sharp LL. PMID: 9850855.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    82. B cell tolerance to a minor, but not to a major, antigenic surface of the self antigen, cytochrome c. J Immunol. 1998 Sep 15; 161(6):2841-7. Jemmerson R, Minnerath JM, Hedrick SM, Oehen S. PMID: 9743344.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    83. A role for FADD in T cell activation and development. Immunity. 1998 Apr; 8(4):439-49. Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM, Hedrick SM. PMID: 9586634.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    84. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J Immunol. 1998 Jan 01; 160(1):120-33. Page DM, Roberts EM, Peschon JJ, Hedrick SM. PMID: 9551964.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    85. The influence of the MAPK pathway on T cell lineage commitment. Immunity. 1997 Nov; 7(5):609-18. Sharp LL, Schwarz DA, Bott CM, Marshall CJ, Hedrick SM. PMID: 9390685.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    86. Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes. Infect Immun. 1997 Jun; 65(6):2306-12. Weintraub BC, Eckmann L, Okamoto S, Hense M, Hedrick SM, Fierer J. PMID: 9169768; PMCID: PMC175320.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    87. A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection. J Immunol. 1996 Jun 15; 156(12):4594-601. Kane LP, Hedrick SM. PMID: 8648101.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    88. Antigen compartmentation and T helper cell tolerance induction. J Exp Med. 1996 Jun 01; 183(6):2617-26. Oehen S, Feng L, Xia Y, Surh CD, Hedrick SM. PMID: 8676082; PMCID: PMC2192597.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    89. Cellular and biochemical requirements for thymocyte negative selection. Semin Immunol. 1996 Apr; 8(2):69-82. Page DM, Kane LP, Onami TM, Hedrick SM. PMID: 8920242.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    90. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 1996 Apr; 4(4):337-47. Matechak EO, Killeen N, Hedrick SM, Fowlkes BJ. PMID: 8612128.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    91. An essential role for gp39, the ligand for CD40, in thymic selection. J Exp Med. 1995 Nov 01; 182(5):1377-88. Foy TM, Page DM, Waldschmidt TJ, Schoneveld A, Laman JD, Masters SR, Tygrett L, Ledbetter JA, Aruffo A, Claassen E, Xu JC, Flavell RA, Oehen S, Hedrick SM, Noelle RJ. PMID: 7595208; PMCID: PMC2192201.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    92. Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells. J Immunol. 1995 Oct 15; 155(8):3847-55. Penninger JM, Timms E, Shahinian A, Jezo-Bremond A, Nishina H, Ionescu J, Hedrick SM, Mak TW. PMID: 7561091.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    93. A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. Mol Cell Biol. 1995 Jun; 15(6):3179-86. Duncan DD, Stupakoff A, Hedrick SM, Marcu KB, Siu G. PMID: 7760814; PMCID: PMC230550.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    94. Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement. J Immunol. 1995 Jun 01; 154(11):5706-14. Kersh GJ, Hooshmand FF, Hedrick SM. PMID: 7751622.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    95. Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity. EMBO J. 1995 Mar 01; 14(5):927-38. Katayama CD, Eidelman FJ, Duncan A, Hooshmand F, Hedrick SM. PMID: 7534228; PMCID: PMC398165.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    96. Role of TCR specificity in CD4 versus CD8 lineage commitment. J Immunol. 1995 Feb 01; 154(3):1057-68. Kersh GJ, Hedrick SM. PMID: 7822783.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    97. MHC blocking peptides and T-cell receptor antagonists: novel paths to selective immunosuppression? Chem Immunol. 1995; 60:61-78. Ruppert J, Franco A, Alexander J, Snoke K, Ishioka GY, Page DM, Hedrick SM, Adorini L, Grey HM, Sette A. PMID: 7857529.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    98. The enigmatic specificity of gamma delta T cells. Immunol Res. 1995; 14(3):163-75. Weintraub BC, Hedrick SM. PMID: 8778207.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    99. Antigen analogs as therapeutic agents. Adv Exp Med Biol. 1995; 386:109-18. Alexander J, Ruppert J, Page DM, Hedrick SM, Franco A, Ishioka GY, Grey HM, Sette A. PMID: 8851019.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    100. Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides. J Immunol. 1994 Oct 01; 153(7):3051-8. Weintraub BC, Jackson MR, Hedrick SM. PMID: 8089486.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    101. Elf-1 binds to a critical element in a second CD4 enhancer. Mol Cell Biol. 1994 Oct; 14(10):6452-63. Wurster AL, Siu G, Leiden JM, Hedrick SM. PMID: 7935370; PMCID: PMC359175.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    102. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 1994 Aug 01; 13(15):3570-9. Siu G, Wurster AL, Duncan DD, Soliman TM, Hedrick SM. PMID: 8062832; PMCID: PMC395261.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    103. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1994 Jun; 1(3):197-205. Linette GP, Grusby MJ, Hedrick SM, Hansen TH, Glimcher LH, Korsmeyer SJ. PMID: 7889408.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    104. Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):4057-61. Page DM, Alexander J, Snoke K, Appella E, Sette A, Hedrick SM, Grey HM. PMID: 7909610; PMCID: PMC43722.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    105. Intracellular signals that mediate thymic negative selection. Immunity. 1994 Apr; 1(1):45-56. Vasquez NJ, Kane LP, Hedrick SM. PMID: 7889398.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    106. Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes. Eur J Immunol. 1993 Oct; 23(10):2482-7. Dent AL, Matis LA, Bluestone JA, Hedrick SM. PMID: 8405049.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    107. Two signals are required for negative selection of CD4+CD8+ thymocytes. J Immunol. 1993 Aug 15; 151(4):1868-80. Page DM, Kane LP, Allison JP, Hedrick SM. PMID: 7688388.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    108. Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science. 1993 Apr 16; 260(5106):358-61. Penninger J, Kishihara K, Molina T, Wallace VA, Timms E, Hedrick SM, Mak TW. PMID: 8469988.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    109. Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage. J Exp Med. 1993 Apr 01; 177(4):1061-70. Wells FB, Tatsumi Y, Bluestone JA, Hedrick SM, Allison JP, Matis LA. PMID: 8459203; PMCID: PMC2190965.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    110. Chimeric T cell receptor-immunoglobulin molecules: function and applications. Int Rev Immunol. 1993; 10(2-3):279-90. Hedrick SM. PMID: 8360589.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    111. Dawn of the hunt for nonclassical MHC function. Cell. 1992 Jul 24; 70(2):177-80. Hedrick SM. PMID: 1322246.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    112. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J Immunol. 1992 Jun 01; 148(11):3342-53. Kaye J, Vasquez NJ, Hedrick SM. PMID: 1316916.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    113. In vivo and in vitro clonal deletion of double-positive thymocytes. J Exp Med. 1992 May 01; 175(5):1307-16. Vasquez NJ, Kaye J, Hedrick SM. PMID: 1314886; PMCID: PMC2119201.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    114. In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors. J Immunol. 1992 Apr 15; 148(8):2363-9. Sandor M, Houlden B, Bluestone J, Hedrick SM, Weinstock J, Lynch RG. PMID: 1532812.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    115. Expression of the CD4 gene requires a Myb transcription factor. Mol Cell Biol. 1992 Apr; 12(4):1592-604. Siu G, Wurster AL, Lipsick JS, Hedrick SM. PMID: 1347906; PMCID: PMC369602.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    116. Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue. J Exp Med. 1992 Jan 01; 175(1):65-70. Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent AL, Hedrick SM, Bluestone JA. PMID: 1730927; PMCID: PMC2119083.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    117. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev. 1991 Oct; 123:115-44. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton RW, Huston G. PMID: 1684776.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    118. Structure and specificity of the T cell antigen receptor. Semin Immunol. 1991 Sep; 3(5):269-81. Kaye J, Kersh G, Engel I, Hedrick SM. PMID: 1724735.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    119. Requirement for positive selection of gamma delta receptor-bearing T cells. Science. 1991 Aug 23; 253(5022):903-5. Wells FB, Gahm SJ, Hedrick SM, Bluestone JA, Dent A, Matis LA. PMID: 1831565.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    120. To T or not to T: is it selection? Curr Biol. 1991 Aug; 1(4):262-4. Matis L, Hedrick S, Bluestone J. PMID: 15336139.
      View in: PubMed   Mentions:    Fields:    
    121. Specificity for molecules of the major histocompatibility complex mediated by a hybrid immunoglobulin-T cell receptor. New Biol. 1991 May; 3(5):487-97. Kawasaki H, Becker ML, Hedrick SM. PMID: 1715754.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    122. Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase. Cell. 1991 Apr 05; 65(1):65-74. Varki A, Hooshmand F, Diaz S, Varki NM, Hedrick SM. PMID: 1826463.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    123. Repertoire development and ligand specificity of murine TCR gamma delta cells. Immunol Rev. 1991 Apr; 120:5-33. Bluestone JA, Cron RQ, Barrett TA, Houlden B, Sperling AI, Dent A, Hedrick S, Rellahan B, Matis LA. PMID: 1650760.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    124. The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire. J Immunol. 1991 Feb 15; 146(4):1093-8. Bhayani HR, Hedrick SM. PMID: 1991960.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    125. Mechanisms of development of alpha beta T cell antigen receptor-bearing cells in gamma delta T cell antigen receptor transgenic mice. Curr Top Microbiol Immunol. 1991; 173:121-31. Dent AL, Hedrick SM. PMID: 1833131.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    126. Control of self-reactivity in the intestine. Immunol Res. 1991; 10(3-4):341-8. Barrett TA, Hedrick SM, Dent AL, Delvy ML, Kennedy DM, Matis LA, Bluestone JA. PMID: 1835488.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    127. A model for gamma delta T-cell development: rearranged gamma- and delta-chain genes incorporated into the germline of mice. Res Immunol. 1990 Sep; 141(7):588-92. Hedrick SM, Dent A. PMID: 2095602.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    128. Molecular analysis of the influences of positive selection, tolerance induction, and antigen presentation on the T cell receptor repertoire. J Exp Med. 1990 Jul 01; 172(1):139-50. Fink PJ, Blair MJ, Matis LA, Hedrick SM. PMID: 2162903; PMCID: PMC2188180.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    129. The biology of the T-cell antigen receptor and its role in the skin immune system. J Invest Dermatol. 1990 Jun; 94(6 Suppl):91S-100S. Siu G, Springer EA, Hedrick SM. PMID: 2191058.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    130. Self-reactive gamma delta T cells are eliminated in the thymus. Nature. 1990 Feb 22; 343(6260):714-9. Dent AL, Matis LA, Hooshmand F, Widacki SM, Bluestone JA, Hedrick SM. PMID: 1968227.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    131. T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones. J Immunol. 1990 Feb 01; 144(3):1127-35. Sorger SB, Paterson Y, Fink PJ, Hedrick SM. PMID: 1688589.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    132. Highly conserved T-cell receptor junctional regions. Evidence for selection at the protein and the DNA level. Immunogenetics. 1990; 31(2):118-22. Sorger SB, Hedrick SM. PMID: 2303278.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    133. Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation. J Immunol. 1989 Dec 01; 143(11):3813-20. Siu G, Hedrick SM, Brian AA. PMID: 2479693.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    134. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 1989 Oct 26; 341(6244):746-9. Kaye J, Hsu ML, Sauron ME, Jameson SC, Gascoigne NR, Hedrick SM. PMID: 2571940.
      View in: PubMed   Mentions: 212     Fields:    Translation:AnimalsCells
    135. Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell. 1989 Sep 08; 58(5):911-21. Becker ML, Near R, Mudgett-Hunter M, Margolies MN, Kubo RT, Kaye J, Hedrick SM. PMID: 2528411.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    136. Characterization of an alternative exon of the murine T cell receptor beta-chain. Pattern of expression and evolutionary conservation. J Immunol. 1989 Jul 01; 143(1):322-8. Dent AL, Fink PJ, Hedrick SM. PMID: 2525149.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    137. Analysis of specificity for antigen, Mls, and allogenic MHC by transfer of T-cell receptor alpha- and beta-chain genes. Nature. 1988 Dec 08; 336(6199):580-3. Kaye J, Hedrick SM. PMID: 2849059.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    138. Site-directed mutations in the VDJ junctional region of a T cell receptor beta chain cause changes in antigenic peptide recognition. Cell. 1988 Aug 12; 54(4):473-84. Engel I, Hedrick SM. PMID: 2456856.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    139. Two distinct mechanisms account for the immune response (Ir) gene control of the T cell response to pigeon cytochrome c. J Immunol. 1988 Jun 15; 140(12):4123-31. McElligott DL, Sorger SB, Matis LA, Hedrick SM. PMID: 2453567.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    140. Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science. 1988 Mar 25; 239(4847):1541-4. Hedrick SM, Engel I, McElligott DL, Fink PJ, Hsu ML, Hansburg D, Matis LA. PMID: 2832942.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    141. The structure of the T cell receptor for antigen is correlated with T cell specificity. Year Immunol. 1988; 3:62-79. Fink PJ, Matis LA, Sorger SB, Hedrick SM. PMID: 2831681.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    142. The influence of MHC gene products on the generation of an antigen-specific T-cell repertoire. Ann N Y Acad Sci. 1988; 532:18-32. Sorger SB, Matis LA, Engel I, McElligott DL, Fink PJ, Hedrick SM. PMID: 2845844.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    143. Specificity of the T cell receptor for antigen. Adv Immunol. 1988; 43:193-234. Hedrick SM. PMID: 2461055.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    144. The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones. Cell. 1987 Oct 09; 51(1):59-69. Matis LA, Sorger SB, McElligott DL, Fink PJ, Hedrick SM. PMID: 2443252.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    145. Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c. J Exp Med. 1987 Feb 01; 165(2):279-301. Sorger SB, Hedrick SM, Fink PJ, Bookman MA, Matis LA. PMID: 3029266; PMCID: PMC2188507.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    146. Correspondence between functionally significant sequences in immunoglobulin and the T cell receptor for antigen. Adv Exp Med Biol. 1987; 213:19-27. Hedrick SM, Engel I, Fink PJ. PMID: 3498298.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    147. Correlations between T-cell specificity and the structure of the antigen receptor. Nature. 1986 May 15-21; 321(6067):219-26. Fink PJ, Matis LA, McElligott DL, Bookman M, Hedrick SM. PMID: 3012351.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    148. Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines. J Exp Med. 1985 May 01; 161(5):1249-54. Reynolds CW, Bonyhadi M, Herberman RB, Young HA, Hedrick SM. PMID: 3872923; PMCID: PMC2187605.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    149. Genetic markers of the antigen-specific T cell receptor locus. J Exp Med. 1985 May 01; 161(5):1219-24. Epstein R, Roehm N, Marrack P, Kappler J, Davis M, Hedrick S, Cohn M. PMID: 2580936; PMCID: PMC2187602.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    150. Isolation of a cDNA clone corresponding to an X-linked gene family (XLR) closely linked to the murine immunodeficiency disorder xid. Nature. 1985 Mar 28-Apr 3; 314(6009):369-72. Cohen DI, Hedrick SM, Nielsen EA, D'Eustachio P, Ruddle F, Steinberg AD, Paul WE, Davis MM. PMID: 2984575.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    151. Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proc Natl Acad Sci U S A. 1985 Jan; 82(2):531-5. Hedrick SM, Germain RN, Bevan MJ, Dorf M, Engel I, Fink P, Gascoigne N, Heber-Katz E, Kapp J, Kaufmann Y, et al. PMID: 2578667; PMCID: PMC397073.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    152. A murine T cell receptor gene complex: isolation, structure and rearrangement. Immunol Rev. 1984 Oct; 81:235-58. Davis MM, Chien YH, Gascoigne NR, Hedrick SM. PMID: 6096259.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    153. Murine T cell receptor beta chain is encoded on chromosome 6. J Exp Med. 1984 Sep 01; 160(3):905-13. Lee NE, D'Eustachio P, Pravtcheva D, Ruddle FH, Hedrick SM, Davis MM. PMID: 6206194; PMCID: PMC2187391.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    154. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature. 1984 Mar 8-14; 308(5955):153-8. Hedrick SM, Nielsen EA, Kavaler J, Cohen DI, Davis MM. PMID: 6546606.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    155. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8-14; 308(5955):149-53. Hedrick SM, Cohen DI, Nielsen EA, Davis MM. PMID: 6199676.
      View in: PubMed   Mentions: 327     Fields:    Translation:AnimalsCells
    156. Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C. J Immunol. 1983 Apr; 130(4):1527-35. Matis LA, Longo DL, Hedrick SM, Hannum C, Margoliash E, Schwartz RH. PMID: 6187812.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    157. The T cell response to allelic determinants on Igh-1-encoded IgG2a antibodies: dual recognition examined by using antigenic antibodies with binding affinity for Ia molecules. J Immunol. 1983 Apr; 130(4):1958-66. Hedrick SM, Schwartz RH. PMID: 6187829.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    158. The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell. 1982 Aug; 30(1):141-52. Hedrick SM, Matis LA, Hecht TT, Samelson LE, Longo DL, Heber-Katz E, Schwartz RH. PMID: 6181895.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    159. I region-restricted antigen presentation by B cell-B lymphoma hybridomas. Nature. 1982 Jul 15; 298(5871):283-4. Glimcher LH, Hamano T, Asofsky R, Herber-Katz E, Hedrick S, Schwartz RH, Paul WE. PMID: 6211627.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    160. The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype. J Immunol. 1982 Jun; 128(6):2439-46. Matis LA, Hedrick SM, Hannum C, Ultee ME, Lebwohl D, Margoliash E, Solinger AM, Lerner EA, Schwartz RH. PMID: 6176634.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    161. Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function. J Exp Med. 1982 Feb 01; 155(2):508-23. Matis LA, Jones PP, Murphy DB, Hedrick SM, Lerner EA, Janeway CA, McNicholas JM, Schwartz RH. PMID: 6173457; PMCID: PMC2186585.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    162. Genetic control of the immune response to collagen. III. Coordinate restriction of cellular cooperation and antigen responsiveness by thymus-directed maturation. J Immunol. 1980 Oct; 125(4):1782-8. Hedrick SM, Watson J. PMID: 6774025.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    163. Characterization of T cell growth factors for the clonal analysis of recognition properties of T cells. Mol Immunol. 1980 Jul; 17(7):1001-10. Watson J, Hedrick SM. PMID: 6163963.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    164. Genetic control of the immune response to collagen. I. Quantitative determination of response levels by multiple I-region genes. J Immunogenet. 1980 Jun; 7(3):271-83. Hedrick SM, Watson JD. PMID: 6774029.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    165. Genetic control of the immune response to collagen. II. Antibody responses produced in fetal liver restored radiation chimeras and thymus reconstituted F1 hybrid nude mice. J Exp Med. 1979 Sep 19; 150(3):646-52. Hedrick SM, Watson J. PMID: 113479; PMCID: PMC2185645.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    166. The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus. J Exp Med. 1977 Dec 01; 146(6):1500-10. Mochizuki D, Hedrick S, Watson J, Kingsbury DT. PMID: 200698; PMCID: PMC2181902.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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