Stephen Hedrick

Title(s)Emeritus Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Mutagenic chain reaction-facilitated immunotherapy
    NIH R01AI131081Sep 9, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Inflammation, Insulin Resistance, and Foxo factors
    NIH R21AI103772Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    A molecular basis for control of T cell memory
    NIH R01AI103440Dec 1, 2012 - Nov 30, 2017
    Role: Principal Investigator
    Control of Lymphocyte Homeostasis by Foxo Transcription Factors
    NIH R01AI073885May 15, 2009 - Aug 30, 2011
    Role: Principal Investigator
    Training in Immunology
    NIH T32AI060536Jul 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Targeted antigens for novel strategies of vaccination
    NIH R21AI055845Sep 30, 2003 - Aug 31, 2005
    Role: Principal Investigator
    DRAK2, a kinase that regulates T cell activation
    NIH R01AI053091Dec 15, 2002 - Nov 30, 2007
    Role: Principal Investigator
    Protein Carbohydrate Interactions in Cell Communication
    NIH U54GM062116Sep 1, 2000 - Dec 31, 2011
    Role: Co-Investigator
    Genetic Modulation of Blood and Vascular Glycosylation
    NIH P01HL057345Sep 30, 1997 - Dec 31, 2013
    Role: Co-Investigator
    SCHLAFEN--THE CONTROL OF THYMOCYTE GROWTH &DEVELOPMENT
    NIH R01CA076554Jul 1, 1997 - Jun 30, 2001
    Role: Principal Investigator
    Cell Biology and Genetics of T Cell Activation and Death
    NIH R01AI037988Jun 1, 1995 - Aug 31, 2016
    Role: Principal Investigator
    ECTOPIC EXPRESSION OF THE RETINOBLASTOMA GENE IN MICE
    NIH R01CA058319May 1, 1992 - Apr 30, 1994
    Role: Principal Investigator
    REGULATION OF CD4 GENE EXPRESSION
    NIH R01AI029990Apr 1, 1991 - Mar 31, 1994
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    T-CELL RECOGNITION ANALYZED BY GENE TRANSFECTION
    NIH R01GM035880Jul 1, 1985 - Jun 30, 1997
    Role: Principal Investigator
    THE T-CELL RECEPTOR: MOLECULAR STRUCTURE AND EXPRESSION
    NIH K04AI000662Jul 1, 1985 - Jun 30, 1990
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    The Regulation of T Cell Development
    NIH R01AI021372Jul 1, 1984 - Aug 30, 2012
    Role: Principal Investigator
    T Cell Receptor Molecular Structure And Expression
    NIH R37AI021372Jul 1, 1984 - Apr 30, 2007
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptomes and metabolism define mouse and human MAIT cell populations. Sci Immunol. 2023 11 10; 8(89):eabn8531. Chandra S, Ascui G, Riffelmacher T, Chawla A, Ramírez-Suástegui C, Castelan VC, Seumois G, Simon H, Murray MP, Seo GY, Premlal ALR, Schmiedel B, Verstichel G, Li Y, Lin CH, Greenbaum J, Lamberti J, Murthy R, Nigro J, Cheroutre H, Ottensmeier CH, Hedrick SM, Lu LF, Vijayanand P, Kronenberg M. PMID: 37948512; PMCID: PMC11160507.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    2. A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation. J Immunol. 2022 09 15; 209(6):1118-1127. Lai CY, Marcel N, Yaldiko AW, Delpoux A, Hedrick SM. PMID: 35948398.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline. PLoS Biol. 2021 Dec; 19(12):e3001478. Weitzel AJ, Grunwald HA, Weber C, Levina R, Gantz VM, Hedrick SM, Bier E, Cooper KL. PMID: 34941868; PMCID: PMC8699911.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    4. Bromodomain protein BRD4 directs and sustains CD8 T cell differentiation during infection. J Exp Med. 2021 08 02; 218(8). Milner JJ, Toma C, Quon S, Omilusik K, Scharping NE, Dey A, Reina-Campos M, Nguyen H, Getzler AJ, Diao H, Yu B, Delpoux A, Yoshida TM, Li D, Qi J, Vincek A, Hedrick SM, Egawa T, Zhou MM, Crotty S, Ozato K, Pipkin ME, Goldrath AW. PMID: 34037670; PMCID: PMC8160575.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    5. CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion. Nat Commun. 2021 05 11; 12(1):2625. Li Z, Marcel N, Devkota S, Auradkar A, Hedrick SM, Gantz VM, Bier E. PMID: 33976171; PMCID: PMC8113449.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    6. FOXO1 constrains activation and regulates senescence in CD8 T cells. Cell Rep. 2021 01 26; 34(4):108674. Delpoux A, Marcel N, Hess Michelini R, Katayama CD, Allison KA, Glass CK, Quiñones-Parra SM, Murre C, Loh L, Kedzierska K, Lappas M, Hedrick SM, Doedens AL. PMID: 33503413.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    7. Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25667-25678. Milner JJ, Nguyen H, Omilusik K, Reina-Campos M, Tsai M, Toma C, Delpoux A, Boland BS, Hedrick SM, Chang JT, Goldrath AW. PMID: 32978300; PMCID: PMC7568335.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    8. Editorial overview: Lymphocyte effector subsets: blurring the frontiers. Curr Opin Immunol. 2020 04; 63:iii-v. Reynaud CA, Hedrick SM. PMID: 32359520.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. A key control point in the T cell response to chronic infection and neoplasia: FOXO1. Curr Opin Immunol. 2020 04; 63:51-60. Marcel N, Hedrick SM. PMID: 32135399; PMCID: PMC8793964.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. The Imperative to Vaccinate. J Pediatr. 2018 10; 201:259-263. Hedrick SM. PMID: 30054163; PMCID: PMC7131101.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    11. Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1. Cell Rep. 2018 03 27; 22(13):3454-3467. Utzschneider DT, Delpoux A, Wieland D, Huang X, Lai CY, Hofmann M, Thimme R, Hedrick SM. PMID: 29590615; PMCID: PMC5942184.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    12. The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection. J Immunol. 2018 02 15; 200(4):1335-1346. Tsau JS, Huang X, Lai CY, Hedrick SM. PMID: 29311359; PMCID: PMC5863746.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells. J Exp Med. 2018 02 05; 215(2):575-594. Delpoux A, Michelini RH, Verma S, Lai CY, Omilusik KD, Utzschneider DT, Redwood AJ, Goldrath AW, Benedict CA, Hedrick SM. PMID: 29282254; PMCID: PMC5789410.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    14. FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity. Proc Natl Acad Sci U S A. 2017 10 17; 114(42):E8865-E8874. Delpoux A, Lai CY, Hedrick SM, Doedens AL. PMID: 28973925; PMCID: PMC5651728.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    15. Understanding Immunity through the Lens of Disease Ecology. Trends Immunol. 2017 12; 38(12):888-903. Hedrick SM. PMID: 28882454; PMCID: PMC5711578.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    16. A rheostat tuning thymic selection. Nat Immunol. 2017 06 20; 18(7):713-714. Morris GP, Hedrick SM. PMID: 28632719.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    17. Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes. Immunity. 2016 10 18; 45(4):774-787. Stienne C, Michieletto MF, Benamar M, Carrié N, Bernard I, Nguyen XH, Lippi Y, Duguet F, Liblau RS, Hedrick SM, Saoudi A, Dejean AS. PMID: 27742544; PMCID: PMC5141513.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    18. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. Elife. 2016 07 04; 5. Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK. PMID: 27376549; PMCID: PMC4931909.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    19. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 05 04; 90(3):535-50. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. PMID: 27112497; PMCID: PMC4860075.
      View in: PubMed   Mentions: 259     Fields:    Translation:AnimalsCells
    20. Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. Stem Cell Reports. 2015 Nov 10; 5(5):866-880. Mah IK, Soloff R, Hedrick SM, Mariani FV. PMID: 26527382; PMCID: PMC4649379.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis. PLoS One. 2015; 10(5):e0126728. Kang H, Corr M, Mansson R, Welinder E, Hedrick SM, Stone EL. PMID: 25969990; PMCID: PMC4430473.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 2015 Feb 17; 42(2):239-251. Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Lin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick SM. PMID: 25692700; PMCID: PMC4334393.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    23. Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. Immunity. 2014 Dec 18; 41(6):934-46. Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL. PMID: 25526308; PMCID: PMC4273651.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. PMID: 25362052; PMCID: PMC4246343.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    25. Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. J Immunol. 2014 Jun 15; 192(12):5548-60. Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H. PMID: 24808358; PMCID: PMC4074511.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    26. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One. 2014; 9(2):e89274. Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V. PMID: 24586650; PMCID: PMC3929751.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    27. Differentiation of CD8 memory T cells depends on Foxo1. J Exp Med. 2013 Jun 03; 210(6):1189-200. Hess Michelini R, Doedens AL, Goldrath AW, Hedrick SM. PMID: 23712431; PMCID: PMC3674697.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    28. Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integr Biol (Camb). 2013 Jan; 5(1):195-203. Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick SM, Almutairi A. PMID: 23060228; PMCID: PMC3535018.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. FOXO transcription factors throughout T cell biology. Nat Rev Immunol. 2012 Sep; 12(9):649-61. Hedrick SM, Hess Michelini R, Doedens AL, Goldrath AW, Stone EL. PMID: 22918467; PMCID: PMC3875397.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    30. Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Adv Mater. 2012 Aug 02; 24(29):3981-7. Gu L, Ruff LE, Qin Z, Corr M, Hedrick SM, Sailor MJ. PMID: 22689074; PMCID: PMC3517000.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    31. Polar opposites: Erk direction of CD4 T cell subsets. J Immunol. 2012 Jul 15; 189(2):721-31. Chang CF, D'Souza WN, Ch'en IL, Pages G, Pouyssegur J, Hedrick SM. PMID: 22675204; PMCID: PMC3392534.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    32. Positive selection in the thymus: an enigma wrapped in a mystery. J Immunol. 2012 Mar 01; 188(5):2043-5. Hedrick SM. PMID: 22345700; PMCID: PMC3387976.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    33. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature. 2011 Sep 14; 477(7364):335-9. Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick SM, Tenzer S, Neurath MF, Becker C. PMID: 21921917; PMCID: PMC3373730.
      View in: PubMed   Mentions: 422     Fields:    Translation:HumansAnimalsCells
    34. Mechanisms of necroptosis in T cells. J Exp Med. 2011 Apr 11; 208(4):633-41. Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM. PMID: 21402742; PMCID: PMC3135356.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    35. Foxo transcription factors control regulatory T cell development and function. Immunity. 2010 Dec 14; 33(6):890-904. Kerdiles YM, Stone EL, Beisner DR, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM. PMID: 21167754; PMCID: PMC3034255.
      View in: PubMed   Mentions: 240     Fields:    Translation:AnimalsCells
    36. Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal. 2011 Feb 15; 14(4):663-74. Dejean AS, Hedrick SM, Kerdiles YM. PMID: 20673126; PMCID: PMC3021368.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    37. Intertwined pathways of programmed cell death in immunity. Immunol Rev. 2010 Jul; 236:41-53. Hedrick SM, Ch'en IL, Alves BN. PMID: 20636807; PMCID: PMC3137483.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    38. Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. J Immunol. 2010 Apr 15; 184(8):4185-95. Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A. PMID: 20231688; PMCID: PMC3085894.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    39. Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. J Immunol. 2009 Oct 15; 183(8):4838-42. McGargill MA, Ch'en IL, Katayama CD, Pagès G, Pouysségur J, Hedrick SM. PMID: 19801509; PMCID: PMC2847885.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. Immune system: not so superior. Science. 2009 Sep 25; 325(5948):1623-4. Hedrick SM. PMID: 19779174; PMCID: PMC2847887.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    41. The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol. 2009 Oct; 10(10):1057-63. Hedrick SM. PMID: 19701188; PMCID: PMC2856448.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimals
    42. MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science. 2009 May 15; 324(5929):938-41. Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS. PMID: 19443782; PMCID: PMC2847890.
      View in: PubMed   Mentions: 249     Fields:    Translation:AnimalsCells
    43. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 2009 May; 10(5):504-13. Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM. PMID: 19363483; PMCID: PMC2712214.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    44. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009 Feb; 10(2):176-84. Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM. PMID: 19136962; PMCID: PMC2856471.
      View in: PubMed   Mentions: 304     Fields:    Translation:AnimalsCells
    45. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol. 2008 Dec 01; 181(11):7593-605. McGargill MA, Choy C, Wen BG, Hedrick SM. PMID: 19017948; PMCID: PMC2792703.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol. 2008 Dec 01; 181(11):7617-29. D'Souza WN, Chang CF, Fischer AM, Li M, Hedrick SM. PMID: 19017950; PMCID: PMC2847891.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    47. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17463-8. Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. PMID: 18981423; PMCID: PMC2582294.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    48. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol. 2008 Aug 01; 181(3):2084-91. Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. PMID: 18641347; PMCID: PMC2494872.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    49. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May; 4(5):313-21. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. PMID: 18408713; PMCID: PMC5434866.
      View in: PubMed   Mentions: 1020     Fields:    Translation:Animals
    50. Thymus lineage commitment: a single switch. Immunity. 2008 Mar; 28(3):297-9. Hedrick SM. PMID: 18342002.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    51. NF-kappaB as a determinant of distinct cell death pathways. Methods Enzymol. 2008; 446:175-87. Ch'en IL, Hedrick SM, Hoffmann A. PMID: 18603122.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    52. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 Jun; 4(6):511-6. Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. PMID: 17486086; PMCID: PMC2932705.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    53. The CD95 receptor: apoptosis revisited. Cell. 2007 May 04; 129(3):447-50. Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH. PMID: 17482535.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    54. Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol. 2006 Jul 15; 177(2):777-81. D'Souza WN, Hedrick SM. PMID: 16818730; PMCID: PMC3137433.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    55. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 2006 Jul; 25(1):93-104. Broussard C, Fleischacker C, Fleischecker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick SM, Fowlkes BJ, Schwartzberg PL. PMID: 16860760.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    56. The TCR of mice and men. J Immunol. 2006 Mar 01; 176(5):2681-2. Hedrick SM. PMID: 16493021.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    57. The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 2005 Oct; 23(4):431-43. Fischer AM, Katayama CD, Pagès G, Pouysségur J, Hedrick SM. PMID: 16226508.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    58. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005 Nov; 17(11):1379-90. Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM. PMID: 16172133.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    59. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol. 2005 Sep 15; 175(6):3469-73. Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM. PMID: 16148088.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    60. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. 1984. J Immunol. 2005 Sep 01; 175(5):2771-5. Hedrick SM, Cohen DI, Nielsen EA, Davis MM. PMID: 16116160.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    61. Central tolerance matters. Immunity. 2005 Aug; 23(2):113-4. Goldrath AW, Hedrick SM. PMID: 16111630.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    62. Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling. J Immunol. 2005 Jul 15; 175(2):656-64. McGargill MA, Sharp LL, Bui JD, Hedrick SM, Calbo S. PMID: 16002660.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
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    149. Correlations between T-cell specificity and the structure of the antigen receptor. Nature. 1986 May 15-21; 321(6067):219-26. Fink PJ, Matis LA, McElligott DL, Bookman M, Hedrick SM. PMID: 3012351.
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    150. Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines. J Exp Med. 1985 May 01; 161(5):1249-54. Reynolds CW, Bonyhadi M, Herberman RB, Young HA, Hedrick SM. PMID: 3872923; PMCID: PMC2187605.
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    151. Genetic markers of the antigen-specific T cell receptor locus. J Exp Med. 1985 May 01; 161(5):1219-24. Epstein R, Roehm N, Marrack P, Kappler J, Davis M, Hedrick S, Cohn M. PMID: 2580936; PMCID: PMC2187602.
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    152. Isolation of a cDNA clone corresponding to an X-linked gene family (XLR) closely linked to the murine immunodeficiency disorder xid. Nature. 1985 Mar 28-Apr 3; 314(6009):369-72. Cohen DI, Hedrick SM, Nielsen EA, D'Eustachio P, Ruddle F, Steinberg AD, Paul WE, Davis MM. PMID: 2984575.
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    153. Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proc Natl Acad Sci U S A. 1985 Jan; 82(2):531-5. Hedrick SM, Germain RN, Bevan MJ, Dorf M, Engel I, Fink P, Gascoigne N, Heber-Katz E, Kapp J, Kaufmann Y, et al. PMID: 2578667; PMCID: PMC397073.
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    154. A murine T cell receptor gene complex: isolation, structure and rearrangement. Immunol Rev. 1984 Oct; 81:235-58. Davis MM, Chien YH, Gascoigne NR, Hedrick SM. PMID: 6096259.
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    155. Murine T cell receptor beta chain is encoded on chromosome 6. J Exp Med. 1984 Sep 01; 160(3):905-13. Lee NE, D'Eustachio P, Pravtcheva D, Ruddle FH, Hedrick SM, Davis MM. PMID: 6206194; PMCID: PMC2187391.
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    156. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature. 1984 Mar 8-14; 308(5955):153-8. Hedrick SM, Nielsen EA, Kavaler J, Cohen DI, Davis MM. PMID: 6546606.
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    157. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8-14; 308(5955):149-53. Hedrick SM, Cohen DI, Nielsen EA, Davis MM. PMID: 6199676.
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    158. The T cell response to allelic determinants on Igh-1-encoded IgG2a antibodies: dual recognition examined by using antigenic antibodies with binding affinity for Ia molecules. J Immunol. 1983 Apr; 130(4):1958-66. Hedrick SM, Schwartz RH. PMID: 6187829.
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    159. Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C. J Immunol. 1983 Apr; 130(4):1527-35. Matis LA, Longo DL, Hedrick SM, Hannum C, Margoliash E, Schwartz RH. PMID: 6187812.
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    160. The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell. 1982 Aug; 30(1):141-52. Hedrick SM, Matis LA, Hecht TT, Samelson LE, Longo DL, Heber-Katz E, Schwartz RH. PMID: 6181895.
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    161. I region-restricted antigen presentation by B cell-B lymphoma hybridomas. Nature. 1982 Jul 15; 298(5871):283-4. Glimcher LH, Hamano T, Asofsky R, Herber-Katz E, Hedrick S, Schwartz RH, Paul WE. PMID: 6211627.
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    162. The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype. J Immunol. 1982 Jun; 128(6):2439-46. Matis LA, Hedrick SM, Hannum C, Ultee ME, Lebwohl D, Margoliash E, Solinger AM, Lerner EA, Schwartz RH. PMID: 6176634.
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    163. Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function. J Exp Med. 1982 Feb 01; 155(2):508-23. Matis LA, Jones PP, Murphy DB, Hedrick SM, Lerner EA, Janeway CA, McNicholas JM, Schwartz RH. PMID: 6173457; PMCID: PMC2186585.
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    164. Genetic control of the immune response to collagen. III. Coordinate restriction of cellular cooperation and antigen responsiveness by thymus-directed maturation. J Immunol. 1980 Oct; 125(4):1782-8. Hedrick SM, Watson J. PMID: 6774025.
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    165. Characterization of T cell growth factors for the clonal analysis of recognition properties of T cells. Mol Immunol. 1980 Jul; 17(7):1001-10. Watson J, Hedrick SM. PMID: 6163963.
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    166. Genetic control of the immune response to collagen. I. Quantitative determination of response levels by multiple I-region genes. J Immunogenet. 1980 Jun; 7(3):271-83. Hedrick SM, Watson JD. PMID: 6774029.
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    167. Genetic control of the immune response to collagen. II. Antibody responses produced in fetal liver restored radiation chimeras and thymus reconstituted F1 hybrid nude mice. J Exp Med. 1979 Sep 19; 150(3):646-52. Hedrick SM, Watson J. PMID: 113479; PMCID: PMC2185645.
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    168. The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus. J Exp Med. 1977 Dec 01; 146(6):1500-10. Mochizuki D, Hedrick S, Watson J, Kingsbury DT. PMID: 200698; PMCID: PMC2181902.
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