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    Stephen Hedrick

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0377
    CA La Jolla 92093
    Phone858-534-6269
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Mutagenic chain reaction-facilitated immunotherapy
      NIH/NIAID R01AI131081Sep 9, 2016 - Aug 31, 2021
      Role: Principal Investigator
      Inflammation, Insulin Resistance, and Foxo factors
      NIH/NIAID R21AI103772Feb 1, 2013 - Jan 31, 2015
      Role: Principal Investigator
      A molecular basis for control of T cell memory
      NIH/NIAID R01AI103440Dec 1, 2012 - Nov 30, 2017
      Role: Principal Investigator
      Control of Lymphocyte Homeostasis by Foxo Transcription Factors
      NIH/NIAID R01AI073885May 15, 2009 - Aug 30, 2011
      Role: Principal Investigator
      Training in Immunology
      NIH/NIAID T32AI060536Jul 1, 2006 - Apr 30, 2012
      Role: Principal Investigator
      Targeted antigens for novel strategies of vaccination
      NIH/NIAID R21AI055845Sep 30, 2003 - Aug 31, 2005
      Role: Principal Investigator
      DRAK2, a kinase that regulates T cell activation
      NIH/NIAID R01AI053091Dec 15, 2002 - Nov 30, 2007
      Role: Principal Investigator
      Protein Carbohydrate Interactions in Cell Communication
      NIH U54GM062116Sep 1, 2000 - Dec 31, 2011
      Role: Co-Investigator
      Genetic Modulation of Blood and Vascular Glycosylation
      NIH/NHLBI P01HL057345Sep 30, 1997 - Dec 31, 2013
      Role: Co-Investigator
      SCHLAFEN--THE CONTROL OF THYMOCYTE GROWTH &DEVELOPMENT
      NIH/NCI R01CA076554Jul 1, 1997 - Jun 30, 2001
      Role: Principal Investigator
      Cell Biology and Genetics of T Cell Activation and Death
      NIH/NIAID R01AI037988Jun 1, 1995 - Aug 31, 2016
      Role: Principal Investigator
      ECTOPIC EXPRESSION OF THE RETINOBLASTOMA GENE IN MICE
      NIH/NCI R01CA058319May 1, 1992 - Apr 30, 1994
      Role: Principal Investigator
      REGULATION OF CD4 GENE EXPRESSION
      NIH/NIAID R01AI029990Apr 1, 1991 - Mar 31, 1994
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      T-CELL RECOGNITION ANALYZED BY GENE TRANSFECTION
      NIH/NIGMS R01GM035880Jul 1, 1985 - Jun 30, 1997
      Role: Principal Investigator
      THE T-CELL RECEPTOR: MOLECULAR STRUCTURE AND EXPRESSION
      NIH/NIAID K04AI000662Jul 1, 1985 - Jun 30, 1990
      Role: Principal Investigator
      INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
      NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
      Role: Co-Investigator
      The Regulation of T Cell Development
      NIH/NIAID R01AI021372Jul 1, 1984 - Aug 30, 2012
      Role: Principal Investigator
      T Cell Receptor Molecular Structure And Expression
      NIH/NIAID R37AI021372Jul 1, 1984 - Apr 30, 2007
      Role: Principal Investigator
      Specialized Cancer Center Support Grant
      NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Morris GP, Hedrick S. A rheostat tuning thymic selection. Nat Immunol. 2017 Jun 20; 18(7):713-714. PMID: 28632719.
        View in: PubMed
      2. Stienne C, Michieletto MF, Benamar M, Carrié N, Bernard I, Nguyen XH, Lippi Y, Duguet F, Liblau RS, Hedrick S, Saoudi A, Dejean AS. Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes. Immunity. 2016 Oct 18; 45(4):774-787. PMID: 27742544.
        View in: PubMed
      3. Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick S, Glass CK. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. Elife. 2016 Jul 04; 5. PMID: 27376549; PMCID: PMC4931909.
      4. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick S, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 2016 May 04; 90(3):535-50. PMID: 27112497; PMCID: PMC4860075 [Available on 05/04/17].
      5. Mah IK, Soloff R, Hedrick S, Mariani FV. Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. Stem Cell Reports. 2015 Nov 10; 5(5):866-80. PMID: 26527382; PMCID: PMC4649379.
      6. Kang H, Corr M, Mansson R, Welinder E, Hedrick S, Stone EL. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis. PLoS One. 2015; 10(5):e0126728. PMID: 25969990; PMCID: PMC4430473.
      7. Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Lin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick S. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 2015 Feb 17; 42(2):239-251. PMID: 25692700; PMCID: PMC4334393.
      8. Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick S, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL. Noncanonical mode of ERK action controls alternative aß and ?d T cell lineage fates. Immunity. 2014 Dec 18; 41(6):934-46. PMID: 25526308; PMCID: PMC4273651 [Available on 12/18/15].
      9. Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick S, Pe'er D, Mathis D, Nolan GP, Benoist C. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. PMID: 25362052; PMCID: PMC4246343.
      10. Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK, Hutcheson J, Hedrick S, Mohan C, Budinger GS, Stehlik C, Perlman H. Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. J Immunol. 2014 Jun 15; 192(12):5548-60. PMID: 24808358; PMCID: PMC4074511.
      11. Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick S, Nizet V. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One. 2014; 9(2):e89274. PMID: 24586650; PMCID: PMC3929751.
      12. Hess Michelini R, Doedens AL, Goldrath AW, Hedrick S. Differentiation of CD8 memory T cells depends on Foxo1. J Exp Med. 2013 Jun 03; 210(6):1189-200. PMID: 23712431; PMCID: PMC3674697.
      13. Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick S, Almutairi A. Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integr Biol (Camb). 2013 Jan; 5(1):195-203. PMID: 23060228; PMCID: PMC3535018.
      14. Hedrick S, Hess Michelini R, Doedens AL, Goldrath AW, Stone EL. FOXO transcription factors throughout T cell biology. Nat Rev Immunol. 2012 Sep; 12(9):649-61. PMID: 22918467; PMCID: PMC3875397.
      15. Gu L, Ruff LE, Qin Z, Corr M, Hedrick S, Sailor MJ. Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Adv Mater. 2012 Aug 02; 24(29):3981-7. PMID: 22689074; PMCID: PMC3517000.
      16. Chang CF, D'Souza WN, Ch'en IL, Pages G, Pouyssegur J, Hedrick S. Polar opposites: Erk direction of CD4 T cell subsets. J Immunol. 2012 Jul 15; 189(2):721-31. PMID: 22675204; PMCID: PMC3392534.
      17. Hedrick S. Positive selection in the thymus: an enigma wrapped in a mystery. J Immunol. 2012 Mar 01; 188(5):2043-5. PMID: 22345700; PMCID: PMC3387976.
      18. Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick S, Tenzer S, Neurath MF, Becker C. Caspase-8 regulates TNF-a-induced epithelial necroptosis and terminal ileitis. Nature. 2011 Sep 14; 477(7364):335-9. PMID: 21921917; PMCID: PMC3373730.
      19. Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick S. Mechanisms of necroptosis in T cells. J Exp Med. 2011 Apr 11; 208(4):633-41. PMID: 21402742; PMCID: PMC3135356.
      20. Kerdiles YM, Stone EL, Beisner DR, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick S. Foxo transcription factors control regulatory T cell development and function. Immunity. 2010 Dec 14; 33(6):890-904. PMID: 21167754; PMCID: PMC3034255.
      21. Dejean AS, Hedrick S, Kerdiles YM. Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal. 2011 Feb 15; 14(4):663-74. PMID: 20673126; PMCID: PMC3021368.
      22. Hedrick S, Ch'en IL, Alves BN. Intertwined pathways of programmed cell death in immunity. Immunol Rev. 2010 Jul; 236:41-53. PMID: 20636807; PMCID: PMC3137483.
      23. Soto PC, Stein LL, Hurtado-Ziola N, Hedrick S, Varki A. Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. J Immunol. 2010 Apr 15; 184(8):4185-95. PMID: 20231688; PMCID: PMC3085894.
      24. McGargill MA, Ch'en IL, Katayama CD, Pagès G, Pouysségur J, Hedrick S. Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. J Immunol. 2009 Oct 15; 183(8):4838-42. PMID: 19801509; PMCID: PMC2847885.
      25. Hedrick S. Immune system: not so superior. Science. 2009 Sep 25; 325(5948):1623-4. PMID: 19779174; PMCID: PMC2847887.
      26. Hedrick S. The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol. 2009 Oct; 10(10):1057-63. PMID: 19701188; PMCID: PMC2856448.
      27. Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick S, Richards JS. MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility. Science. 2009 May 15; 324(5929):938-41. PMID: 19443782; PMCID: PMC2847890.
      28. Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick S. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 2009 May; 10(5):504-13. PMID: 19363483; PMCID: PMC2712214.
      29. Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick S. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009 Feb; 10(2):176-84. PMID: 19136962; PMCID: PMC2856471.
      30. McGargill MA, Choy C, Wen BG, Hedrick S. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol. 2008 Dec 01; 181(11):7593-605. PMID: 19017948; PMCID: PMC2792703.
      31. D'Souza WN, Chang CF, Fischer AM, Li M, Hedrick S. The Erk2 MAPK regulates CD8 T cell proliferation and survival. J Immunol. 2008 Dec 01; 181(11):7617-29. PMID: 19017950; PMCID: PMC2847891.
      32. Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick S. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17463-8. PMID: 18981423; PMCID: PMC2582294.
      33. Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick S, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol. 2008 Aug 01; 181(3):2084-91. PMID: 18641347; PMCID: PMC2494872.
      34. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick S, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May; 4(5):313-21. PMID: 18408713.
        View in: PubMed
      35. Hedrick S. Thymus lineage commitment: a single switch. Immunity. 2008 Mar; 28(3):297-9. PMID: 18342002.
        View in: PubMed
      36. Ch'en IL, Hedrick S, Hoffmann A. NF-kappaB as a determinant of distinct cell death pathways. Methods Enzymol. 2008; 446:175-87. PMID: 18603122.
        View in: PubMed
      37. Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick S, Shokat KM. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 Jun; 4(6):511-6. PMID: 17486086; PMCID: PMC2932705.
      38. Peter ME, Budd RC, Desbarats J, Hedrick S, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH. The CD95 receptor: apoptosis revisited. Cell. 2007 May 04; 129(3):447-50. PMID: 17482535.
        View in: PubMed
      39. D'Souza WN, Hedrick S. Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol. 2006 Jul 15; 177(2):777-81. PMID: 16818730; PMCID: PMC3137433.
      40. Broussard C, Fleischacker C, Fleischecker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick S, Fowlkes BJ, Schwartzberg PL. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 2006 Jul; 25(1):93-104. PMID: 16860760.
        View in: PubMed
      41. Hedrick S. The TCR of mice and men. J Immunol. 2006 Mar 01; 176(5):2681-2. PMID: 16493021.
        View in: PubMed
      42. Fischer AM, Katayama CD, Pagès G, Pouysségur J, Hedrick S. The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 2005 Oct; 23(4):431-43. PMID: 16226508.
        View in: PubMed
      43. Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick S, Walsh CM. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005 Nov; 17(11):1379-90. PMID: 16172133.
        View in: PubMed
      44. Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick S. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol. 2005 Sep 15; 175(6):3469-73. PMID: 16148088.
        View in: PubMed
      45. Hedrick S, Cohen DI, Nielsen EA, Davis MM. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. 1984. J Immunol. 2005 Sep 01; 175(5):2771-5. PMID: 16116160.
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      46. Goldrath AW, Hedrick S. Central tolerance matters. Immunity. 2005 Aug; 23(2):113-4. PMID: 16111630.
        View in: PubMed
      47. McGargill MA, Sharp LL, Bui JD, Hedrick S, Calbo S. Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling. J Immunol. 2005 Jul 15; 175(2):656-64. PMID: 16002660.
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      48. Catlett IM, Hedrick S. Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells. Nat Immunol. 2005 Jul; 6(7):715-21. PMID: 15924143.
        View in: PubMed
      49. Lin MY, Zal T, Ch'en IL, Gascoigne NR, Hedrick S. A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol. 2005 May 01; 174(9):5583-92. PMID: 15843557.
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      50. Sato K, Imai Y, Higashi N, Kumamoto Y, Onami TM, Hedrick S, Irimura T. Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Blood. 2005 Jul 01; 106(1):207-15. PMID: 15784728.
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      51. McGargill MA, Wen BG, Walsh CM, Hedrick S. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity. 2004 Dec; 21(6):781-91. PMID: 15589167; PMCID: PMC2792702.
      52. Hedrick S. The acquired immune system: a vantage from beneath. Immunity. 2004 Nov; 21(5):607-15. PMID: 15539148.
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      53. Soloff RS, Katayama C, Lin MY, Feramisco JR, Hedrick S. Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol. 2004 Sep 01; 173(5):3250-60. PMID: 15322187.
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      54. Beisner DR, Chu IH, Arechiga AF, Hedrick S, Walsh CM. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol. 2003 Jul 01; 171(1):247-56. PMID: 12817005.
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      55. Brinkman-Van der Linden EC, Angata T, Reynolds SA, Powell LD, Hedrick S, Varki A. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Mol Cell Biol. 2003 Jun; 23(12):4199-206. PMID: 12773563; PMCID: PMC156146.
      56. Mertsching E, Wurster AL, Katayama C, Esko J, Ramsdell F, Marth JD, Hedrick S. A mouse strain defective for alphabeta versus gammadelta T cell lineage commitment. Int Immunol. 2002 Sep; 14(9):1039-53. PMID: 12202401.
        View in: PubMed
      57. Onami TM, Lin MY, Page DM, Reynolds SA, Katayama CD, Marth JD, Irimura T, Varki A, Varki N, Hedrick S. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol Cell Biol. 2002 Jul; 22(14):5173-81. PMID: 12077344; PMCID: PMC139776.
      58. Tsuiji M, Fujimori M, Ohashi Y, Higashi N, Onami TM, Hedrick S, Irimura T. Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1. J Biol Chem. 2002 Aug 09; 277(32):28892-901. PMID: 12016228.
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      59. Hedrick S. T cell development: bottoms-up. Immunity. 2002 May; 16(5):619-22. PMID: 12049714.
        View in: PubMed
      60. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):179-83. PMID: 11557984.
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      61. Bain G, Cravatt CB, Loomans C, Alberola-Ila J, Hedrick S, Murre C. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat Immunol. 2001 Feb; 2(2):165-71. PMID: 11175815.
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      62. Hayden-Martinez K, Kane LP, Hedrick S. Effects of a constitutively active form of calcineurin on T cell activation and thymic selection. J Immunol. 2000 Oct 01; 165(7):3713-21. PMID: 11034376.
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      63. Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, Hedrick S, Mandel G, Glass CK, Rose DW, Rosenfeld MG. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 2000 Sep 15; 102(6):753-63. PMID: 11030619.
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      64. Bui JD, Calbo S, Hayden-Martinez K, Kane LP, Gardner P, Hedrick S. A role for CaMKII in T cell memory. Cell. 2000 Feb 18; 100(4):457-67. PMID: 10693762.
        View in: PubMed
      65. Sharp LL, Hedrick S. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling. J Immunol. 1999 Dec 15; 163(12):6598-605. PMID: 10586054.
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      66. Bain G, Quong MW, Soloff RS, Hedrick S, Murre C. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J Exp Med. 1999 Dec 06; 190(11):1605-16. PMID: 10587351; PMCID: PMC2195738.
      67. Schwarz DA, Katayama CD, Hedrick S. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity. 1998 Nov; 9(5):657-68. PMID: 9846487.
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      68. Hedrick S, Sharp LL. T-cell fate. Immunol Rev. 1998 Oct; 165:95-110. PMID: 9850855.
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      69. Jemmerson R, Minnerath JM, Hedrick S, Oehen S. B cell tolerance to a minor, but not to a major, antigenic surface of the self antigen, cytochrome c. J Immunol. 1998 Sep 15; 161(6):2841-7. PMID: 9743344.
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      70. Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM, Hedrick S. A role for FADD in T cell activation and development. Immunity. 1998 Apr; 8(4):439-49. PMID: 9586634.
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      71. Page DM, Roberts EM, Peschon JJ, Hedrick S. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J Immunol. 1998 Jan 01; 160(1):120-33. PMID: 9551964.
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      72. Sharp LL, Schwarz DA, Bott CM, Marshall CJ, Hedrick S. The influence of the MAPK pathway on T cell lineage commitment. Immunity. 1997 Nov; 7(5):609-18. PMID: 9390685.
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      73. Weintraub BC, Eckmann L, Okamoto S, Hense M, Hedrick S, Fierer J. Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes. Infect Immun. 1997 Jun; 65(6):2306-12. PMID: 9169768; PMCID: PMC175320.
      74. Kane LP, Hedrick S. A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection. J Immunol. 1996 Jun 15; 156(12):4594-601. PMID: 8648101.
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      75. Oehen S, Feng L, Xia Y, Surh CD, Hedrick S. Antigen compartmentation and T helper cell tolerance induction. J Exp Med. 1996 Jun 01; 183(6):2617-26. PMID: 8676082; PMCID: PMC2192597.
      76. Page DM, Kane LP, Onami TM, Hedrick S. Cellular and biochemical requirements for thymocyte negative selection. Semin Immunol. 1996 Apr; 8(2):69-82. PMID: 8920242.
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      77. Matechak EO, Killeen N, Hedrick S, Fowlkes BJ. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 1996 Apr; 4(4):337-47. PMID: 8612128.
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      78. Foy TM, Page DM, Waldschmidt TJ, Schoneveld A, Laman JD, Masters SR, Tygrett L, Ledbetter JA, Aruffo A, Claassen E, Xu JC, Flavell RA, Oehen S, Hedrick S, Noelle RJ. An essential role for gp39, the ligand for CD40, in thymic selection. J Exp Med. 1995 Nov 01; 182(5):1377-88. PMID: 7595208; PMCID: PMC2192201.
      79. Penninger JM, Timms E, Shahinian A, Jezo-Bremond A, Nishina H, Ionescu J, Hedrick S, Mak TW. Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells. J Immunol. 1995 Oct 15; 155(8):3847-55. PMID: 7561091.
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      80. Duncan DD, Stupakoff A, Hedrick S, Marcu KB, Siu G. A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. Mol Cell Biol. 1995 Jun; 15(6):3179-86. PMID: 7760814; PMCID: PMC230550.
      81. Kersh GJ, Hooshmand FF, Hedrick S. Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement. J Immunol. 1995 Jun 01; 154(11):5706-14. PMID: 7751622.
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      82. Katayama CD, Eidelman FJ, Duncan A, Hooshmand F, Hedrick S. Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity. EMBO J. 1995 Mar 01; 14(5):927-38. PMID: 7534228; PMCID: PMC398165.
      83. Kersh GJ, Hedrick S. Role of TCR specificity in CD4 versus CD8 lineage commitment. J Immunol. 1995 Feb 01; 154(3):1057-68. PMID: 7822783.
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      84. Ruppert J, Franco A, Alexander J, Snoke K, Ishioka GY, Page DM, Hedrick S, Adorini L, Grey HM, Sette A. MHC blocking peptides and T-cell receptor antagonists: novel paths to selective immunosuppression? Chem Immunol. 1995; 60:61-78. PMID: 7857529.
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      85. Weintraub BC, Hedrick S. The enigmatic specificity of gamma delta T cells. Immunol Res. 1995; 14(3):163-75. PMID: 8778207.
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      86. Alexander J, Ruppert J, Page DM, Hedrick S, Franco A, Ishioka GY, Grey HM, Sette A. Antigen analogs as therapeutic agents. Adv Exp Med Biol. 1995; 386:109-18. PMID: 8851019.
        View in: PubMed
      87. Weintraub BC, Jackson MR, Hedrick S. Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides. J Immunol. 1994 Oct 01; 153(7):3051-8. PMID: 8089486.
        View in: PubMed
      88. Wurster AL, Siu G, Leiden JM, Hedrick S. Elf-1 binds to a critical element in a second CD4 enhancer. Mol Cell Biol. 1994 Oct; 14(10):6452-63. PMID: 7935370; PMCID: PMC359175.
      89. Siu G, Wurster AL, Duncan DD, Soliman TM, Hedrick S. A transcriptional silencer controls the developmental expression of the CD4 gene. EMBO J. 1994 Aug 01; 13(15):3570-9. PMID: 8062832; PMCID: PMC395261.
      90. Linette GP, Grusby MJ, Hedrick S, Hansen TH, Glimcher LH, Korsmeyer SJ. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1994 Jun; 1(3):197-205. PMID: 7889408.
        View in: PubMed
      91. Page DM, Alexander J, Snoke K, Appella E, Sette A, Hedrick S, Grey HM. Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):4057-61. PMID: 7909610; PMCID: PMC43722.
      92. Vasquez NJ, Kane LP, Hedrick S. Intracellular signals that mediate thymic negative selection. Immunity. 1994 Apr; 1(1):45-56. PMID: 7889398.
        View in: PubMed
      93. Dent AL, Matis LA, Bluestone JA, Hedrick S. Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes. Eur J Immunol. 1993 Oct; 23(10):2482-7. PMID: 8405049.
        View in: PubMed
      94. Page DM, Kane LP, Allison JP, Hedrick S. Two signals are required for negative selection of CD4+CD8+ thymocytes. J Immunol. 1993 Aug 15; 151(4):1868-80. PMID: 7688388.
        View in: PubMed
      95. Penninger J, Kishihara K, Molina T, Wallace VA, Timms E, Hedrick S, Mak TW. Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science. 1993 Apr 16; 260(5106):358-61. PMID: 8469988.
        View in: PubMed
      96. Wells FB, Tatsumi Y, Bluestone JA, Hedrick S, Allison JP, Matis LA. Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage. J Exp Med. 1993 Apr 01; 177(4):1061-70. PMID: 8459203; PMCID: PMC2190965.
      97. Hedrick S. Chimeric T cell receptor-immunoglobulin molecules: function and applications. Int Rev Immunol. 1993; 10(2-3):279-90. PMID: 8360589.
        View in: PubMed
      98. Hedrick S. Dawn of the hunt for nonclassical MHC function. Cell. 1992 Jul 24; 70(2):177-80. PMID: 1322246.
        View in: PubMed
      99. Kaye J, Vasquez NJ, Hedrick S. Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition. J Immunol. 1992 Jun 01; 148(11):3342-53. PMID: 1316916.
        View in: PubMed
      100. Vasquez NJ, Kaye J, Hedrick S. In vivo and in vitro clonal deletion of double-positive thymocytes. J Exp Med. 1992 May 01; 175(5):1307-16. PMID: 1314886; PMCID: PMC2119201.
      101. Sandor M, Houlden B, Bluestone J, Hedrick S, Weinstock J, Lynch RG. In vitro and in vivo activation of murine gamma/delta T cells induces the expression of IgA, IgM, and IgG Fc receptors. J Immunol. 1992 Apr 15; 148(8):2363-9. PMID: 1532812.
        View in: PubMed
      102. Siu G, Wurster AL, Lipsick JS, Hedrick S. Expression of the CD4 gene requires a Myb transcription factor. Mol Cell Biol. 1992 Apr; 12(4):1592-604. PMID: 1347906; PMCID: PMC369602.
      103. Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent AL, Hedrick S, Bluestone JA. Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue. J Exp Med. 1992 Jan 01; 175(1):65-70. PMID: 1730927; PMCID: PMC2119083.
      104. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick S, Dutton RW, Huston G. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev. 1991 Oct; 123:115-44. PMID: 1684776.
        View in: PubMed
      105. Kaye J, Kersh G, Engel I, Hedrick S. Structure and specificity of the T cell antigen receptor. Semin Immunol. 1991 Sep; 3(5):269-81. PMID: 1724735.
        View in: PubMed
      106. Wells FB, Gahm SJ, Hedrick S, Bluestone JA, Dent A, Matis LA. Requirement for positive selection of gamma delta receptor-bearing T cells. Science. 1991 Aug 23; 253(5022):903-5. PMID: 1831565.
        View in: PubMed
      107. Matis L, Hedrick S, Bluestone J. To T or not to T: is it selection? Curr Biol. 1991 Aug; 1(4):262-4. PMID: 15336139.
        View in: PubMed
      108. Kawasaki H, Becker ML, Hedrick S. Specificity for molecules of the major histocompatibility complex mediated by a hybrid immunoglobulin-T cell receptor. New Biol. 1991 May; 3(5):487-97. PMID: 1715754.
        View in: PubMed
      109. Varki A, Hooshmand F, Diaz S, Varki NM, Hedrick S. Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase. Cell. 1991 Apr 05; 65(1):65-74. PMID: 1826463.
        View in: PubMed
      110. Bluestone JA, Cron RQ, Barrett TA, Houlden B, Sperling AI, Dent A, Hedrick S, Rellahan B, Matis LA. Repertoire development and ligand specificity of murine TCR gamma delta cells. Immunol Rev. 1991 Apr; 120:5-33. PMID: 1650760.
        View in: PubMed
      111. Bhayani HR, Hedrick S. The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire. J Immunol. 1991 Feb 15; 146(4):1093-8. PMID: 1991960.
        View in: PubMed
      112. Barrett TA, Hedrick S, Dent AL, Delvy ML, Kennedy DM, Matis LA, Bluestone JA. Control of self-reactivity in the intestine. Immunol Res. 1991; 10(3-4):341-8. PMID: 1835488.
        View in: PubMed
      113. Dent AL, Hedrick S. Mechanisms of development of alpha beta T cell antigen receptor-bearing cells in gamma delta T cell antigen receptor transgenic mice. Curr Top Microbiol Immunol. 1991; 173:121-31. PMID: 1833131.
        View in: PubMed
      114. Hedrick S, Dent A. A model for gamma delta T-cell development: rearranged gamma- and delta-chain genes incorporated into the germline of mice. Res Immunol. 1990 Sep; 141(7):588-92. PMID: 2095602.
        View in: PubMed
      115. Fink PJ, Blair MJ, Matis LA, Hedrick S. Molecular analysis of the influences of positive selection, tolerance induction, and antigen presentation on the T cell receptor repertoire. J Exp Med. 1990 Jul 01; 172(1):139-50. PMID: 2162903; PMCID: PMC2188180.
      116. Siu G, Springer EA, Hedrick S. The biology of the T-cell antigen receptor and its role in the skin immune system. J Invest Dermatol. 1990 Jun; 94(6 Suppl):91S-100S. PMID: 2191058.
        View in: PubMed
      117. Dent AL, Matis LA, Hooshmand F, Widacki SM, Bluestone JA, Hedrick S. Self-reactive gamma delta T cells are eliminated in the thymus. Nature. 1990 Feb 22; 343(6260):714-9. PMID: 1968227.
        View in: PubMed
      118. Sorger SB, Paterson Y, Fink PJ, Hedrick S. T cell receptor junctional regions and the MHC molecule affect the recognition of antigenic peptides by T cell clones. J Immunol. 1990 Feb 01; 144(3):1127-35. PMID: 1688589.
        View in: PubMed
      119. Sorger SB, Hedrick S. Highly conserved T-cell receptor junctional regions. Evidence for selection at the protein and the DNA level. Immunogenetics. 1990; 31(2):118-22. PMID: 2303278.
        View in: PubMed
      120. Siu G, Hedrick S, Brian AA. Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation. J Immunol. 1989 Dec 01; 143(11):3813-20. PMID: 2479693.
        View in: PubMed
      121. Kaye J, Hsu ML, Sauron ME, Jameson SC, Gascoigne NR, Hedrick S. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 1989 Oct 26; 341(6244):746-9. PMID: 2571940.
        View in: PubMed
      122. Becker ML, Near R, Mudgett-Hunter M, Margolies MN, Kubo RT, Kaye J, Hedrick S. Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell. 1989 Sep 08; 58(5):911-21. PMID: 2528411.
        View in: PubMed
      123. Dent AL, Fink PJ, Hedrick S. Characterization of an alternative exon of the murine T cell receptor beta-chain. Pattern of expression and evolutionary conservation. J Immunol. 1989 Jul 01; 143(1):322-8. PMID: 2525149.
        View in: PubMed
      124. Kaye J, Hedrick S. Analysis of specificity for antigen, Mls, and allogenic MHC by transfer of T-cell receptor alpha- and beta-chain genes. Nature. 1988 Dec 08; 336(6199):580-3. PMID: 2849059.
        View in: PubMed
      125. Engel I, Hedrick S. Site-directed mutations in the VDJ junctional region of a T cell receptor beta chain cause changes in antigenic peptide recognition. Cell. 1988 Aug 12; 54(4):473-84. PMID: 2456856.
        View in: PubMed
      126. McElligott DL, Sorger SB, Matis LA, Hedrick S. Two distinct mechanisms account for the immune response (Ir) gene control of the T cell response to pigeon cytochrome c. J Immunol. 1988 Jun 15; 140(12):4123-31. PMID: 2453567.
        View in: PubMed
      127. Hedrick S, Engel I, McElligott DL, Fink PJ, Hsu ML, Hansburg D, Matis LA. Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science. 1988 Mar 25; 239(4847):1541-4. PMID: 2832942.
        View in: PubMed
      128. Sorger SB, Matis LA, Engel I, McElligott DL, Fink PJ, Hedrick S. The influence of MHC gene products on the generation of an antigen-specific T-cell repertoire. Ann N Y Acad Sci. 1988; 532:18-32. PMID: 2845844.
        View in: PubMed
      129. Hedrick S. Specificity of the T cell receptor for antigen. Adv Immunol. 1988; 43:193-234. PMID: 2461055.
        View in: PubMed
      130. Fink PJ, Matis LA, Sorger SB, Hedrick S. The structure of the T cell receptor for antigen is correlated with T cell specificity. Year Immunol. 1988; 3:62-79. PMID: 2831681.
        View in: PubMed
      131. Matis LA, Sorger SB, McElligott DL, Fink PJ, Hedrick S. The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones. Cell. 1987 Oct 09; 51(1):59-69. PMID: 2443252.
        View in: PubMed
      132. Sorger SB, Hedrick S, Fink PJ, Bookman MA, Matis LA. Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c. J Exp Med. 1987 Feb 01; 165(2):279-301. PMID: 3029266; PMCID: PMC2188507.
      133. Hedrick S, Engel I, Fink PJ. Correspondence between functionally significant sequences in immunoglobulin and the T cell receptor for antigen. Adv Exp Med Biol. 1987; 213:19-27. PMID: 3498298.
        View in: PubMed
      134. Fink PJ, Matis LA, McElligott DL, Bookman M, Hedrick S. Correlations between T-cell specificity and the structure of the antigen receptor. Nature. 1986 May 15-21; 321(6067):219-26. PMID: 3012351.
        View in: PubMed
      135. Epstein R, Roehm N, Marrack P, Kappler J, Davis M, Hedrick S, Cohn M. Genetic markers of the antigen-specific T cell receptor locus. J Exp Med. 1985 May 01; 161(5):1219-24. PMID: 2580936; PMCID: PMC2187602.
      136. Reynolds CW, Bonyhadi M, Herberman RB, Young HA, Hedrick S. Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines. J Exp Med. 1985 May 01; 161(5):1249-54. PMID: 3872923; PMCID: PMC2187605.
      137. Cohen DI, Hedrick S, Nielsen EA, D'Eustachio P, Ruddle F, Steinberg AD, Paul WE, Davis MM. Isolation of a cDNA clone corresponding to an X-linked gene family (XLR) closely linked to the murine immunodeficiency disorder xid. Nature. 1985 Mar 28-Apr 3; 314(6009):369-72. PMID: 2984575.
        View in: PubMed
      138. Hedrick S, Germain RN, Bevan MJ, Dorf M, Engel I, Fink P, Gascoigne N, Heber-Katz E, Kapp J, Kaufmann Y. Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proc Natl Acad Sci U S A. 1985 Jan; 82(2):531-5. PMID: 2578667; PMCID: PMC397073.
      139. Davis MM, Chien YH, Gascoigne NR, Hedrick S. A murine T cell receptor gene complex: isolation, structure and rearrangement. Immunol Rev. 1984 Oct; 81:235-58. PMID: 6096259.
        View in: PubMed
      140. Lee NE, D'Eustachio P, Pravtcheva D, Ruddle FH, Hedrick S, Davis MM. Murine T cell receptor beta chain is encoded on chromosome 6. J Exp Med. 1984 Sep 01; 160(3):905-13. PMID: 6206194; PMCID: PMC2187391.
      141. Hedrick S, Nielsen EA, Kavaler J, Cohen DI, Davis MM. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature. 1984 Mar 8-14; 308(5955):153-8. PMID: 6546606.
        View in: PubMed
      142. Hedrick S, Cohen DI, Nielsen EA, Davis MM. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature. 1984 Mar 8-14; 308(5955):149-53. PMID: 6199676.
        View in: PubMed
      143. Matis LA, Longo DL, Hedrick S, Hannum C, Margoliash E, Schwartz RH. Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C. J Immunol. 1983 Apr; 130(4):1527-35. PMID: 6187812.
        View in: PubMed
      144. Hedrick S, Schwartz RH. The T cell response to allelic determinants on Igh-1-encoded IgG2a antibodies: dual recognition examined by using antigenic antibodies with binding affinity for Ia molecules. J Immunol. 1983 Apr; 130(4):1958-66. PMID: 6187829.
        View in: PubMed
      145. Hedrick S, Matis LA, Hecht TT, Samelson LE, Longo DL, Heber-Katz E, Schwartz RH. The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell. 1982 Aug; 30(1):141-52. PMID: 6181895.
        View in: PubMed
      146. Glimcher LH, Hamano T, Asofsky R, Herber-Katz E, Hedrick S, Schwartz RH, Paul WE. I region-restricted antigen presentation by B cell-B lymphoma hybridomas. Nature. 1982 Jul 15; 298(5871):283-4. PMID: 6211627.
        View in: PubMed
      147. Matis LA, Hedrick S, Hannum C, Ultee ME, Lebwohl D, Margoliash E, Solinger AM, Lerner EA, Schwartz RH. The T lymphocyte response to cytochrome C. III. Relationship of the fine specificity of antigen recognition to major histocompatibility complex genotype. J Immunol. 1982 Jun; 128(6):2439-46. PMID: 6176634.
        View in: PubMed
      148. Matis LA, Jones PP, Murphy DB, Hedrick S, Lerner EA, Janeway CA, McNicholas JM, Schwartz RH. Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function. J Exp Med. 1982 Feb 01; 155(2):508-23. PMID: 6173457; PMCID: PMC2186585.
      149. Hedrick S, Watson J. Genetic control of the immune response to collagen. III. Coordinate restriction of cellular cooperation and antigen responsiveness by thymus-directed maturation. J Immunol. 1980 Oct; 125(4):1782-8. PMID: 6774025.
        View in: PubMed
      150. Watson J, Hedrick S. Characterization of T cell growth factors for the clonal analysis of recognition properties of T cells. Mol Immunol. 1980 Jul; 17(7):1001-10. PMID: 6163963.
        View in: PubMed
      151. Hedrick S, Watson JD. Genetic control of the immune response to collagen. I. Quantitative determination of response levels by multiple I-region genes. J Immunogenet. 1980 Jun; 7(3):271-83. PMID: 6774029.
        View in: PubMed
      152. Hedrick S, Watson J. Genetic control of the immune response to collagen. II. Antibody responses produced in fetal liver restored radiation chimeras and thymus reconstituted F1 hybrid nude mice. J Exp Med. 1979 Sep 19; 150(3):646-52. PMID: 113479; PMCID: PMC2185645.
      153. Mochizuki D, Hedrick S, Watson J, Kingsbury DT. The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus. J Exp Med. 1977 Dec 01; 146(6):1500-10. PMID: 200698; PMCID: PMC2181902.