Karen Oegema

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    The Oegema lab takes parallel approaches in mammalian cells and using the C. elegans embryo as a metazoan model system to study cell division and embryonic development.

    Research Focus Area:

  • Cell Division and Cell Cycle Control

  • Genetics and Genomics

  • Signal Transduction

  • Stem Cell Biology

  • Systems Biology


  • Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity. J Cell Biol. 2021 07 05; 220(7). Meitinger F, Kong D, Ohta M, Desai A, Oegema K, Loncarek J. PMID: 33983387.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly. Mol Biol Cell. 2021 06 01; 32(12):1193-1201. de Groot C, Houston J, Davis B, Gerson-Gurwitz A, Monen J, Lara-Gonzalez P, Oegema K, Shiau AK, Desai A. PMID: 33852350.
      View in: PubMed   Mentions: 1     Fields:    
    3. Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome. J Cell Biol. 2021 02 01; 220(2). Ohta M, Zhao Z, Wu D, Wang S, Harrison JL, Gómez-Cavazos JS, Desai A, Oegema KF. PMID: 33399854.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores. Science. 2021 01 01; 371(6524):64-67. Lara-Gonzalez P, Kim T, Oegema K, Corbett K, Desai A. PMID: 33384372.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Centriole-independent mitotic spindle assembly relies on the PCNT-CDK5RAP2 pericentriolar matrix. J Cell Biol. 2020 12 07; 219(12). Watanabe S, Meitinger F, Shiau AK, Oegema K, Desai A. PMID: 33170211.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. TRIM37 controls cancer-specific vulnerability to PLK4 inhibition. Nature. 2020 09; 585(7825):440-446. Meitinger F, Ohta M, Lee KY, Watanabe S, Davis RL, Anzola JV, Kabeche R, Jenkins DA, Shiau AK, Desai A, Oegema K. PMID: 32908304.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    7. A Non-canonical BRCT-Phosphopeptide Recognition Mechanism Underlies RhoA Activation in Cytokinesis. Curr Biol. 2020 08 17; 30(16):3101-3115.e11. Gómez-Cavazos JS, Lee KY, Lara-González P, Li Y, Desai A, Shiau AK, Oegema K. PMID: 32619481.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development. J Vis Exp. 2019 10 29; (152). Khaliullin RN, Hendel JM, Gerson-Gurwitz A, Wang S, Ochoa SD, Zhao Z, Desai A, Oegema K, Green RA. PMID: 31736498.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C. Dev Cell. 2019 11 04; 51(3):313-325.e10. Lara-Gonzalez P, Moyle MW, Budrewicz J, Mendoza-Lopez J, Oegema K, Desai A. PMID: 31588029.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    10. Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. J Cell Biol. 2019 11 04; 218(11):3795-3811. Gerson-Gurwitz A, Worby CA, Lee KY, Khaliullin R, Bouffard J, Cheerambathur D, Oegema K, Cram EJ, Dixon JE, Desai A. PMID: 31541016.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity. Curr Biol. 2019 09 23; 29(18):3072-3080.e5. Gemble S, Simon A, Pennetier C, Dumont M, Hervé S, Meitinger F, Oegema K, Rodriguez R, Almouzni G, Fachinetti D, Basto R. PMID: 31495582.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    12. A high-content imaging approach to profile C. elegans embryonic development. Development. 2019 04 11; 146(7). Wang S, Ochoa SD, Khaliullin RN, Gerson-Gurwitz A, Hendel JM, Zhao Z, Biggs R, Chisholm AD, Desai A, Oegema K, Green RA. PMID: 30890570.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis. Dev Cell. 2019 03 25; 48(6):864-872.e7. Cheerambathur DK, Prevo B, Chow TL, Hattersley N, Wang S, Zhao Z, Kim T, Gerson-Gurwitz A, Oegema K, Green R, Desai A. PMID: 30827898.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. The ARP2/3 complex prevents excessive formin activity during cytokinesis. Mol Biol Cell. 2019 01 01; 30(1):96-107. Chan FY, Silva AM, Saramago J, Pereira-Sousa J, Brighton HE, Pereira M, Oegema K, Gassmann R, Carvalho AX. PMID: 30403552.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. CFI-400945 is not a selective cellular PLK4 inhibitor. Proc Natl Acad Sci U S A. 2018 11 13; 115(46):E10808-E10809. Oegema K, Davis RL, Lara-Gonzalez P, Desai A, Shiau AK. PMID: 30377272.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    16. CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia. Elife. 2018 07 10; 7. Lee KY, Green RA, Gutierrez E, Gomez-Cavazos JS, Kolotuev I, Wang S, Desai A, Groisman A, Oegema K. PMID: 29989548.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans. Elife. 2018 07 02; 7. Khaliullin RN, Green RA, Shi LZ, Gomez-Cavazos JS, Berns MW, Desai A, Oegema K. PMID: 29963981.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    18. Correction: Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation (doi:10.1242/dev.126615). Development. 2018 05 14; 145(10). Quintin S, Wang S, Pontabry J, Bender A, Robin F, Hyenne V, Landmann F, Gally C, Oegema K, Labouesse M. PMID: 29759977.
      View in: PubMed   Mentions:    Fields:    
    19. Employing the one-cell C. elegans embryo to study cell division processes. Methods Cell Biol. 2018; 144:185-231. Hattersley N, Lara-Gonzalez P, Cheerambathur D, Gomez-Cavazos JS, Kim T, Prevo B, Khaliullin R, Lee KY, Ohta M, Green R, Oegema K, Desai A. PMID: 29804670.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    20. TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis. J Cell Biol. 2018 03 05; 217(3):837-848. Mangal S, Sacher J, Kim T, Osório DS, Motegi F, Carvalho AX, Oegema K, Zanin E. PMID: 29311228.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    21. A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans. Development. 2017 07 15; 144(14):2694-2701. Wang S, Tang NH, Lara-Gonzalez P, Zhao Z, Cheerambathur DK, Prevo B, Chisholm AD, Desai A, Oegema K. PMID: 28619826.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    22. Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates. Genes Dev. 2017 06 01; 31(11):1089-1094. Kim T, Lara-Gonzalez P, Prevo B, Meitinger F, Cheerambathur DK, Oegema K, Desai A. PMID: 28698300.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    23. Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. Dev Cell. 2017 05 22; 41(4):424-437.e4. Cheerambathur DK, Prevo B, Hattersley N, Lewellyn L, Corbett KD, Oegema K, Desai A. PMID: 28535376.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    24. How centrioles acquire the ability to reproduce. Elife. 2017 03 08; 6. Ohta M, Desai A, Oegema K. PMID: 28271993.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    25. Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation. Biol Open. 2016 Oct 15; 5(10):1431-1440. Wueseke O, Zwicker D, Schwager A, Wong YL, Oegema K, Jülicher F, Hyman AA, Woodruff JB. PMID: 27591191.
      View in: PubMed   Mentions:
    26. GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. Mol Biol Cell. 2016 12 01; 27(24):3828-3840. Xing M, Peterman MC, Davis RL, Oegema K, Shiau AK, Field SJ. PMID: 27708138.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    27. A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly. Dev Cell. 2016 09 12; 38(5):463-77. Hattersley N, Cheerambathur D, Moyle M, Stefanutti M, Richardson A, Lee KY, Dumont J, Oegema K, Desai A. PMID: 27623381.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016 07 18; 214(2):155-66. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. PMID: 27432897.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    29. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Cell. 2016 Apr 07; 165(2):396-409. Gerson-Gurwitz A, Wang S, Sathe S, Green R, Yeo GW, Oegema K, Desai A. PMID: 27020753.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    30. Correction: Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. J Cell Biol. 2016 Mar 14; 212(6):737. Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A. PMID: 26953348.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    31. Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation. Development. 2016 Jan 01; 143(1):160-73. Quintin S, Wang S, Pontabry J, Bender A, Robin F, Hyenne V, Landmann F, Gally C, Oegema K, Labouesse M. PMID: 26586219.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    32. NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans. Elife. 2015 Sep 15; 4:e08649. Wang S, Wu D, Quintin S, Green RA, Cheerambathur DK, Ochoa SD, Desai A, Oegema K. PMID: 26371552.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    33. Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. J Cell Biol. 2015 May 25; 209(4):507-17. Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A. PMID: 25987605.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro. Science. 2015 May 15; 348(6236):808-12. Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA. PMID: 25977552.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    35. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 05; 348(6239):1155-60. Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, Mitchell BJ, Desai A, Gahman TC, Shiau AK, Oegema K. PMID: 25931445.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    36. Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans. PLoS One. 2015; 10(4):e0125382. Monen J, Hattersley N, Muroyama A, Stevens D, Oegema K, Desai A. PMID: 25919583.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    37. The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast. Curr Biol. 2015 Feb 02; 25(3):348-356. Folco HD, Campbell CS, May KM, Espinoza CA, Oegema K, Hardwick KG, Grewal SIS, Desai A. PMID: 25619765.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    38. Methods in Cell Biology. Centrosome & Centriole. Preface. Methods Cell Biol. 2015; 129:xvii-xix. Basto R, Oegema K. PMID: 26376502.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    39. The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans. Cell Rep. 2014 Nov 06; 9(3):874-83. Chuang M, Goncharov A, Wang S, Oegema K, Jin Y, Chisholm AD. PMID: 25437544.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    40. The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix. Mol Biol Cell. 2014 Oct 01; 25(19):2984-92. Wueseke O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA. PMID: 25103243.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases. Structure. 2014 Aug 05; 22(8):1090-1104. Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R, Svergun DI, Round A, Oegema K, Dong G. PMID: 24980795.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    42. A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J Cell Biol. 2014 Mar 03; 204(5):647-57. Moyle MW, Kim T, Hattersley N, Espeut J, Cheerambathur DK, Oegema K, Desai A. PMID: 24567362.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    43. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 2014 Jan 15; 28(2):121-6. Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon JE, Oegema K. PMID: 24449268.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    44. Meiotic double-strand breaks uncover and protect against mitotic errors in the C. elegans germline. Curr Biol. 2013 Dec 02; 23(23):2400-6. Stevens D, Oegema K, Desai A. PMID: 24239117.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    45. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Science. 2013 Dec 06; 342(6163):1239-42. Cheerambathur DK, Gassmann R, Cook B, Oegema K, Desai A. PMID: 24231804.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    46. The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules. J Cell Biol. 2013 Nov 11; 203(3):505-20. Green RA, Mayers JR, Wang S, Lewellyn L, Desai A, Audhya A, Oegema K. PMID: 24217623.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    47. Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly. Elife. 2013 Sep 17; 2:e01071. Cottee MA, Muschalik N, Wong YL, Johnson CM, Johnson S, Andreeva A, Oegema K, Lea SM, Raff JW, van Breugel M. PMID: 24052813.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    48. A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. Dev Cell. 2013 Sep 16; 26(5):496-510. Zanin E, Desai A, Poser I, Toyoda Y, Andree C, Moebius C, Bickle M, Conradt B, Piekny A, Oegema K. PMID: 24012485.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    49. Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. Dev Cell. 2013 May 13; 25(3):284-98. Lettman MM, Wong YL, Viscardi V, Niessen S, Chen SH, Shiau AK, Zhou H, Desai A, Oegema K. PMID: 23673331.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    50. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr; 21(2):101-6. Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW. PMID: 23580138.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    51. Hierarchical assembly of the eggshell and permeability barrier in C. elegans. J Cell Biol. 2012 Aug 20; 198(4):731-48. Olson SK, Greenan G, Desai A, Müller-Reichert T, Oegema K. PMID: 22908315.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    52. Cytokinesis in animal cells. Annu Rev Cell Dev Biol. 2012; 28:29-58. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Green RA, Paluch E, Oegema K. PMID: 22804577.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    53. An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Nature. 2012 Apr 08; 484(7395):534-7. Gassmann R, Rechtsteiner A, Yuen KW, Muroyama A, Egelhofer T, Gaydos L, Barron F, Maddox P, Essex A, Monen J, Ercan S, Lieb JD, Oegema K, Strome S, Desai A. PMID: 22495302.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    54. Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. J Cell Biol. 2012 Feb 20; 196(4):469-82. Espeut J, Cheerambathur DK, Krenning L, Oegema K, Desai A. PMID: 22331849.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    55. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem. 2012 Jan 27; 287(5):3123-37. Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, Graham M, Reue K, Dixon JE, Goodman JM. PMID: 22134922.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    56. Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos. Curr Biol. 2011 Nov 08; 21(21):1800-7. Yuen KW, Nabeshima K, Oegema K, Desai A. PMID: 22018540.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    57. Acute drug treatment in the early C. elegans embryo. PLoS One. 2011; 6(9):e24656. Carvalho A, Olson SK, Gutierrez E, Zhang K, Noble LB, Zanin E, Desai A, Groisman A, Oegema K. PMID: 21935434.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    58. Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. PLoS One. 2011; 6(8):e22969. Stevens D, Gassmann R, Oegema K, Desai A. PMID: 21829677.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    59. A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell. 2011 Apr 29; 145(3):470-82. Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K. PMID: 21529718.
      View in: PubMed   Mentions: 108     Fields:    Translation:Animals
    60. The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly. J Cell Biol. 2011 Apr 04; 193(1):155-69. Lewellyn L, Carvalho A, Desai A, Maddox AS, Oegema K. PMID: 21464231.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    61. Affinity purification of protein complexes in C. elegans. Methods Cell Biol. 2011; 106:289-322. Zanin E, Dumont J, Gassmann R, Cheeseman I, Maddox P, Bahmanyar S, Carvalho A, Niessen S, Yates JR, Oegema K, Desai A. PMID: 22118282.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    62. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010 Sep; 12(9):894-901. Dumont J, Oegema K, Desai A. PMID: 20729837.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    63. Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev. 2010 May; 24(9):957-71. Gassmann R, Holland AJ, Varma D, Wan X, Civril F, Cleveland DW, Oegema K, Salmon ED, Desai A. PMID: 20439434.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    64. Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo. Mol Biol Cell. 2010 Jan 01; 21(1):50-62. Lewellyn L, Dumont J, Desai A, Oegema K. PMID: 19889842.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    65. The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev. 2009 Sep 01; 23(17):2046-59. Dammermann A, Pemble H, Mitchell BJ, McLeod I, Yates JR, Kintner C, Desai AB, Oegema K. PMID: 19656802.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    66. Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size. Cell. 2009 May 29; 137(5):926-37. Carvalho A, Desai A, Oegema K. PMID: 19490897.
      View in: PubMed   Mentions: 95     Fields:    Translation:Animals
    67. Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. Mol Biol Cell. 2009 Feb; 20(4):1252-67. Essex A, Dammermann A, Lewellyn L, Oegema K, Desai A. PMID: 19109417.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    68. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science. 2008 Dec 05; 322(5907):1543-6. Canman JC, Lewellyn L, Laband K, Smerdon SJ, Desai A, Bowerman B, Oegema K. PMID: 19056985.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    69. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008 Sep 01; 22(17):2385-99. Gassmann R, Essex A, Hu JS, Maddox PS, Motegi F, Sugimoto A, O'Rourke SM, Bowerman B, McLeod I, Yates JR, Oegema K, Cheeseman IM, Desai A. PMID: 18765790.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    70. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. J Cell Biol. 2008 Feb 25; 180(4):771-85. Dammermann A, Maddox PS, Desai A, Oegema K. PMID: 18299348.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    71. Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo. Methods Cell Biol. 2008; 85:179-218. Green RA, Audhya A, Pozniakovsky A, Dammermann A, Pemble H, Monen J, Portier N, Hyman A, Desai A, Oegema K. PMID: 18155464.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    72. MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. PLoS One. 2007 Sep 26; 2(9):e956. Audhya A, McLeod IX, Yates JR, Oegema K. PMID: 17895996.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    73. A role for Rab5 in structuring the endoplasmic reticulum. J Cell Biol. 2007 Jul 02; 178(1):43-56. Audhya A, Desai A, Oegema K. PMID: 17591921.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    74. Anillin and the septins promote asymmetric ingression of the cytokinetic furrow. Dev Cell. 2007 May; 12(5):827-35. Maddox AS, Lewellyn L, Desai A, Oegema K. PMID: 17488632.
      View in: PubMed   Mentions: 70     Fields:    Translation:Animals
    75. A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. Dev Cell. 2007 Apr; 12(4):515-29. Portier N, Audhya A, Maddox PS, Green RA, Dammermann A, Desai A, Oegema K. PMID: 17419991.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    76. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. J Cell Biol. 2007 Mar 12; 176(6):757-63. Maddox PS, Hyndman F, Monen J, Oegema K, Desai A. PMID: 17339379.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    77. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell. 2007 Jan 12; 128(1):115-27. Schlaitz AL, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, de Robillard Q, Zinke A, Yates JR, Müller-Reichert T, Shevchenko A, Oegema K, Hyman AA. PMID: 17218259.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    78. Katanin controls mitotic and meiotic spindle length. J Cell Biol. 2006 Dec 18; 175(6):881-91. McNally K, Audhya A, Oegema K, McNally FJ. PMID: 17178907.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    79. A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Cell. 2006 Dec 15; 127(6):1179-91. Sandall S, Severin F, McLeod IX, Yates JR, Oegema K, Hyman A, Desai A. PMID: 17174893.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    80. Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15097-102. Maddox PS, Portier N, Desai A, Oegema K. PMID: 17005720.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    81. Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. J Cell Biol. 2006 Jun 19; 173(6):985-94. Olson SK, Bishop JR, Yates JR, Oegema K, Esko JD. PMID: 16785326.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    82. Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans. Mol Biol Cell. 2006 Jul; 17(7):3085-94. Sato K, Sato M, Audhya A, Oegema K, Schweinsberg P, Grant BD. PMID: 16672374.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    83. Cell division. WormBook. 2006 Jan 19; 1-40. Oegema K, Hyman AA. PMID: 18050484.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    84. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat Cell Biol. 2005 Dec; 7(12):1248-55. Monen J, Maddox PS, Hyndman F, Oegema K, Desai A. PMID: 16273096.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    85. A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J Cell Biol. 2005 Oct 24; 171(2):267-79. Audhya A, Hyndman F, McLeod IX, Maddox AS, Yates JR, Desai A, Oegema K. PMID: 16247027.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    86. Distinct roles for two C. elegans anillins in the gonad and early embryo. Development. 2005 Jun; 132(12):2837-48. Maddox AS, Habermann B, Desai A, Oegema K. PMID: 15930113.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    87. The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation. Curr Biol. 2005 Apr 26; 15(8):771-7. Cheeseman IM, MacLeod I, Yates JR, Oegema K, Desai A. PMID: 15854912.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    88. Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature. 2005 Mar 24; 434(7032):462-9. Sönnichsen B, Koski LB, Walsh A, Marschall P, Neumann B, Brehm M, Alleaume AM, Artelt J, Bettencourt P, Cassin E, Hewitson M, Holz C, Khan M, Lazik S, Martin C, Nitzsche B, Ruer M, Stamford J, Winzi M, Heinkel R, Röder M, Finell J, Häntsch H, Jones SJ, Jones M, Piano F, Gunsalus KC, Oegema K, Gönczy P, Coulson A, Hyman AA, Echeverri CJ. PMID: 15791247.
      View in: PubMed   Mentions: 400     Fields:    Translation:Animals
    89. Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell. 2004 Dec; 7(6):815-29. Dammermann A, Müller-Reichert T, Pelletier L, Habermann B, Desai A, Oegema K. PMID: 15572125.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    90. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004 Sep 15; 18(18):2255-68. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A. PMID: 15371340.
      View in: PubMed   Mentions: 220     Fields:    Translation:HumansAnimalsCells
    91. "Holo"er than thou: chromosome segregation and kinetochore function in C. elegans. Chromosome Res. 2004; 12(6):641-53. Maddox PS, Oegema K, Desai A, Cheeseman IM. PMID: 15289669.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    92. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 2003 Oct 01; 17(19):2421-35. Desai A, Rybina S, Müller-Reichert T, Shevchenko A, Shevchenko A, Hyman A, Oegema K. PMID: 14522947.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    93. Deconstructing cytokinesis. Nat Cell Biol. 2003 Sep; 5(9):773-6. Maddox AS, Oegema K. PMID: 12951607.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    94. The minus end in sight. Curr Biol. 2003 Aug 05; 13(15):R614-24. Dammermann A, Desai A, Oegema K. PMID: 12906817.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    95. Closing the GAP: a role for a RhoA GAP in cytokinesis. Mol Cell. 2003 Apr; 11(4):846-8. Maddox AS, Oegema K. PMID: 12718869.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    96. SAS-4 is a C. elegans centriolar protein that controls centrosome size. Cell. 2003 Feb 21; 112(4):575-87. Kirkham M, Müller-Reichert T, Oegema K, Grill S, Hyman AA. PMID: 12600319.
      View in: PubMed   Mentions: 134     Fields:    Translation:AnimalsCells
    97. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol. 2002 Oct 01; 12(19):1670-4. Maddox P, Desai A, Oegema K, Mitchison TJ, Salmon ED. PMID: 12361570.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    98. The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol. 2002 May 13; 157(4):591-602. Hannak E, Oegema K, Kirkham M, Gönczy P, Habermann B, Hyman AA. PMID: 12011109.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    99. Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans. J Cell Biol. 2001 Dec 24; 155(7):1109-16. Hannak E, Kirkham M, Hyman AA, Oegema K. PMID: 11748251.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    100. Functional analysis of kinetochore assembly in Caenorhabditis elegans. J Cell Biol. 2001 Jun 11; 153(6):1209-26. Oegema K, Desai A, Rybina S, Kirkham M, Hyman AA. PMID: 11402065.
      View in: PubMed   Mentions: 207     Fields:    Translation:AnimalsCells
    101. Purification and reconstitution of Drosophila gamma-tubulin complexes. Methods Cell Biol. 2001; 67:1-25. Gunawardane RN, Zheng Y, Oegema K, Wiese C. PMID: 11550462.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    102. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature. 2000 Nov 16; 408(6810):331-6. Gönczy P, Echeverri C, Oegema K, Coulson A, Jones SJ, Copley RR, Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S, Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlü N, Bork P, Hyman AA. PMID: 11099034.
      View in: PubMed   Mentions: 276     Fields:    Translation:AnimalsCells
    103. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. J Cell Biol. 2000 Aug 07; 150(3):539-52. Oegema K, Savoian MS, Mitchison TJ, Field CM. PMID: 10931866.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    104. Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. J Cell Biol. 1999 Feb 22; 144(4):721-33. Oegema K, Wiese C, Martin OC, Milligan RA, Iwamatsu A, Mitchison TJ, Zheng Y. PMID: 10037793.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    105. Cytokinesis in eukaryotes: a mechanistic comparison. Curr Opin Cell Biol. 1999 Feb; 11(1):68-80. Field C, Li R, Oegema K. PMID: 10047527.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    106. Live confocal analysis with fluorescently labeled proteins. Methods Mol Biol. 1999; 122:223-39. Francis-Lang H, Minden J, Sullivan W, Oegema K. PMID: 10231795.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    107. Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds. J Cell Biol. 1998 Aug 10; 142(3):775-86. Moritz M, Zheng Y, Alberts BM, Oegema K. PMID: 9700165.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    108. Purification of cytoskeletal proteins using peptide antibodies. Methods Enzymol. 1998; 298:525-41. Field CM, Oegema K, Zheng Y, Mitchison TJ, Walczak CE. PMID: 9751906.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    109. Purification and assay of a septin complex from Drosophila embryos. Methods Enzymol. 1998; 298:279-95. Oegema K, Desai A, Wong ML, Mitchison TJ, Field CM. PMID: 9751888.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    110. Two proteins that cycle asynchronously between centrosomes and nuclear structures: Drosophila CP60 and CP190. J Cell Sci. 1997 Jul; 110 ( Pt 14):1573-83. Oegema K, Marshall WF, Sedat JW, Alberts BM. PMID: 9247191.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    111. Rappaport rules: cleavage furrow induction in animal cells. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):4817-20. Oegema K, Mitchison TJ. PMID: 9144146.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    112. The cell cycle-dependent localization of the CP190 centrosomal protein is determined by the coordinate action of two separable domains. J Cell Biol. 1995 Dec; 131(5):1261-73. Oegema K, Whitfield WG, Alberts B. PMID: 8522588.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    113. CP60: a microtubule-associated protein that is localized to the centrosome in a cell cycle-specific manner. Mol Biol Cell. 1995 Dec; 6(12):1673-84. Kellogg DR, Oegema K, Raff J, Schneider K, Alberts BM. PMID: 8590797.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    114. The 190 kDa centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes. J Cell Sci. 1995 Nov; 108 ( Pt 11):3377-87. Whitfield WG, Chaplin MA, Oegema K, Parry H, Glover DM. PMID: 8586650.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    115. Studies on the centrosome and cytoplasmic organization in the early Drosophila embryo. Cold Spring Harb Symp Quant Biol. 1991; 56:649-62. Kellogg DR, Sullivan W, Theurkauf W, Oegema K, Raff JW, Alberts BM. PMID: 1840267.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    116. The gene encoding ARS-binding factor I is essential for the viability of yeast. Genes Dev. 1989 Dec; 3(12A):1926-39. Rhode PR, Sweder KS, Oegema KF, Campbell JL. PMID: 2620828.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
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