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    Shizhen Wang

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Targeting Chemotherapy-induced Breast Cancer Stemness
      NIH/NCI R01CA206911Aug 1, 2017 - Jul 31, 2022
      Role: Principal Investigator
      Role of breast cancer-secreted miRNA in directing a stromal metabolic plasticity
      NIH/NCI R01CA218140Aug 1, 2017 - Jul 31, 2022
      Role: Principal Investigator
      Role of miR-105 in breast cancer metastasis
      NIH/NCI R01CA166020Sep 1, 2012 - Jun 30, 2017
      Role: Principal Investigator
      Mechanism of chemoresistance mediated by TGF-beta
      NIH/NCI R01CA163586May 1, 2012 - Mar 31, 2017
      Role: Principal Investigator
      Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
      NIH/NCI R00CA125892Jul 25, 2007 - Jun 30, 2012
      Role: Principal Investigator
      Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
      NIH/NCI K99CA125892Jul 25, 2007 - Jun 30, 2009
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, Chen Y, Locasale JW, Wang S. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018 Apr 16. PMID: 29662176.
        View in: PubMed
      2. Liu L, Yang L, Yan W, Zhai J, Pizzo D, Chu P, Chin AR, Shen M, Dong C, Ruan X, Ren X, Somlo G, Wang S. Chemotherapy induces breast cancer stemness in association with dysregulated monocytosis. Clin Cancer Res. 2018 Mar 02. PMID: 29500278.
        View in: PubMed
      3. Jiang S, Yan W, Wang S, Baltimore D. Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients. Cell Metab. 2018 Jan 10. PMID: 29337138.
        View in: PubMed
      4. Liu L, Zhang L, Yang L, Li H, Li R, Yu J, Yang L, Wei F, Yan C, Sun Q, Zhao H, Yang F, Jin H, Wang J, Wang S, Ren X. Anti-CD47 Antibody As a Targeted Therapeutic Agent for Human Lung Cancer and Cancer Stem Cells. Front Immunol. 2017; 8:404. PMID: 28484448.
        View in: PubMed
      5. Chin AR, Wang S. Cancer-derived extracellular vesicles: the 'soil conditioner' in breast cancer metastasis? Cancer Metastasis Rev. 2016 Dec; 35(4):669-676. PMID: 27838868.
        View in: PubMed
      6. Zhang K, Wu X, Wang J, Lopez J, Zhou W, Yang L, Wang S, Raz DJ, Kim JY. Circulating miRNA profile in esophageal adenocarcinoma. Am J Cancer Res. 2016; 6(11):2713-2721. PMID: 27904783.
        View in: PubMed
      7. Chin AR, Wang S. Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications. Clin Cancer Res. 2016 Aug 01; 22(15):3725-33. PMID: 27252414; PMCID: PMC4970897 [Available on 08/01/17].
      8. Chin AR, Fong MY, Somlo G, Wu J, Swiderski P, Wu X, Wang S. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res. 2016 Feb; 26(2):217-28. PMID: 26794868; PMCID: PMC4746606 [Available on 02/01/17].
      9. Fong MY, Zhou W, Liu L, Alontaga AY, Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR, Somlo G, Palomares M, Li Z, Tremblay JR, Tsuyada A, Sun G, Reid MA, Wu X, Swiderski P, Ren X, Shi Y, Kong M, Zhong W, Chen Y, Wang S. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015 Feb; 17(2):183-94. PMID: 25621950; PMCID: PMC4380143.
      10. Fong MY, Wang S. The exploits of cancer's greedy sweet-tooth. Cell Cycle. 2015; 14(12):1768-9. PMID: 25928026; PMCID: PMC4615071.
      11. Liu L, Zhou W, Cheng CT, Ren X, Somlo G, Fong MY, Chin AR, Li H, Yu Y, Xu Y, O'Connor ST, O'Connor TR, Ann DK, Stark JM, Wang S. TGFß induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes. Mol Cancer Res. 2014 Nov; 12(11):1597-609. PMID: 25103497; PMCID: PMC4233161.
      12. Chow A, Zhou W, Liu L, Fong MY, Champer J, Van Haute D, Chin AR, Ren X, Gugiu BG, Meng Z, Huang W, Ngo V, Kortylewski M, Wang S. Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-?B. Sci Rep. 2014 Jul 18; 4:5750. PMID: 25034888; PMCID: PMC4102923.
      13. Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, Yu Y, Chow A, O'Connor ST, Chin AR, Yen Y, Wang Y, Marcusson EG, Chu P, Wu J, Wu X, Li AX, Li Z, Gao H, Ren X, Boldin MP, Lin PC, Wang S. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014 Apr 14; 25(4):501-15. PMID: 24735924; PMCID: PMC4016197.
      14. Chin AR, Wang S. Cytokines driving breast cancer stemness. Mol Cell Endocrinol. 2014 Jan 25; 382(1):598-602. PMID: 23562748.
        View in: PubMed
      15. Zheng YW, Li H, Yu JP, Zhao H, Wang S, Ren XB. Interferon-?s: special immunomodulatory agents and potential therapeutic targets. J Innate Immun. 2013; 5(3):209-18. PMID: 23207147.
        View in: PubMed
      16. Li R, Wang C, Liu L, Du C, Cao S, Yu J, Wang S, Hao X, Ren X, Li H. Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study. Cancer Immunol Immunother. 2012 Nov; 61(11):2125-33. PMID: 22581306.
        View in: PubMed
      17. Tsuyada A, Chow A, Wu J, Somlo G, Chu P, Loera S, Luu T, Li AX, Wu X, Ye W, Chen S, Zhou W, Yu Y, Wang YZ, Ren X, Li H, Scherle P, Kuroki Y, Wang S. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 2012 Jun 01; 72(11):2768-79. PMID: 22472119; PMCID: PMC3367125.
      18. Chandra M, Zang S, Li H, Zimmerman LJ, Champer J, Tsuyada A, Chow A, Zhou W, Yu Y, Gao H, Ren X, Lin RJ, Wang S. Nuclear translocation of type I transforming growth factor ß receptor confers a novel function in RNA processing. Mol Cell Biol. 2012 Jun; 32(12):2183-95. PMID: 22473997; PMCID: PMC3372271.
      19. Wu X, Somlo G, Yu Y, Palomares MR, Li AX, Zhou W, Chow A, Yen Y, Rossi JJ, Gao H, Wang J, Yuan YC, Frankel P, Li S, Ashing-Giwa KT, Sun G, Wang Y, Smith R, Robinson K, Ren X, Wang S. De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J Transl Med. 2012 Mar 08; 10:42. PMID: 22400902; PMCID: PMC3342150.
      20. Zhang J, Li H, Yu JP, Wang S, Ren XB. Role of SOCS1 in tumor progression and therapeutic application. Int J Cancer. 2012 May 01; 130(9):1971-80. PMID: 22025331.
        View in: PubMed
      21. Yu J, Sun J, Wang S, Li H, Cao S, Cong Y, Liu J, Ren X. Upregulated expression of indoleamine 2, 3-dioxygenase in primary breast cancer correlates with increase of infiltrated regulatory T cells in situ and lymph node metastasis. Clin Dev Immunol. 2011; 2011:469135. PMID: 22110525; PMCID: PMC3202140.
      22. Yu Y, Wang Y, Ren X, Tsuyada A, Li A, Liu LJ, Wang S. Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor ß contributes to chemoresistance in breast cancer cells. Mol Cancer Res. 2010 Dec; 8(12):1633-42. PMID: 21047769; PMCID: PMC3059495.
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