Shizhen Wang

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-5036-8175 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Nankai UniversityPh.D.Virology
    University of Nebraska, LincolnPh.D. (joint)Virology
    Johns Hopkins Universitypost-docViral Oncology
    Vanderbilt Universitypost-docCancer Biology

    Collapse Overview 
    Collapse Overview
    We study cancer as a whole-body-level disorder rather than a mass at the tissue or cellular level. Most cancers take years to develop, busy becoming ‘the fittest’ by adapting to the environment and––to a certain extent––altering the environment in the body. Our group has a long-standing interest in understanding the multifaceted interactions between tumor and host at the Molecular, Cellular, and Organ levels. We believe the cross-system effects of cancer will be a critical aspect in clinical care, to ensure that we not only remove the malignant lesion but also restore a healthy system to prevent recurrence and other diseases. We currently focus on mechanisms mediated by cancer-secreted extracellular vesicles and their microRNA and protein cargo, for their role in systemic manifestations and comorbidities of breast cancer such as metabolic diseases, cachexia, and neurological disorders.

    Collapse Research 
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    Targeting Chemotherapy-induced Breast Cancer Stemness
    NIH/NCI R01CA206911Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Role of breast cancer-secreted miRNA in directing a stromal metabolic plasticity
    NIH/NCI R01CA218140Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Role of miR-105 in breast cancer metastasis
    NIH/NCI R01CA166020Sep 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Mechanism of chemoresistance mediated by TGF-beta
    NIH/NCI R01CA163586May 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
    NIH/NCI R00CA125892Jul 25, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
    NIH/NCI K99CA125892Jul 25, 2007 - Jun 30, 2009
    Role: Principal Investigator

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