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Shizhen Wang

TitleAssociate Professor In Residence
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0612
La Jolla CA 92093
Phone858-246-2464
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting Chemotherapy-induced Breast Cancer Stemness
    NIH/NCI R01CA206911Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Role of breast cancer-secreted miRNA in directing a stromal metabolic plasticity
    NIH/NCI R01CA218140Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Role of miR-105 in breast cancer metastasis
    NIH/NCI R01CA166020Sep 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Mechanism of chemoresistance mediated by TGF-beta
    NIH/NCI R01CA163586May 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
    NIH/NCI R00CA125892Jul 25, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
    NIH/NCI K99CA125892Jul 25, 2007 - Jun 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chin AR, Yan W, Cao M, Liu X, Wang S. Polarized Secretion of Extracellular Vesicles by Mammary Epithelia. J Mammary Gland Biol Neoplasia. 2018 Jul 03. PMID: 29968174.
      View in: PubMed
    2. Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, Chen Y, Locasale JW, Wang S. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018 Apr 16. PMID: 29662176.
      View in: PubMed
    3. Liu L, Yang L, Yan W, Zhai J, Pizzo D, Chu P, Chin AR, Shen M, Dong C, Ruan X, Ren X, Somlo G, Wang S. Chemotherapy induces breast cancer stemness in association with dysregulated monocytosis. Clin Cancer Res. 2018 Mar 02. PMID: 29500278.
      View in: PubMed
    4. Shen M, Wang J, Yu W, Zhang C, Liu M, Wang K, Yang L, Wei F, Wang S, Sun Q, Ren X. A novel MDSC-induced PD-1-PD-L1+ B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties. Oncoimmunology. 2018; 7(4):e1413520. PMID: 29632731.
      View in: PubMed
    5. Jiang S, Yan W, Wang S, Baltimore D. Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients. Cell Metab. 2018 Jan 10. PMID: 29337138.
      View in: PubMed
    6. Liu L, Zhang L, Yang L, Li H, Li R, Yu J, Yang L, Wei F, Yan C, Sun Q, Zhao H, Yang F, Jin H, Wang J, Wang S, Ren X. Anti-CD47 Antibody As a Targeted Therapeutic Agent for Human Lung Cancer and Cancer Stem Cells. Front Immunol. 2017; 8:404. PMID: 28484448.
      View in: PubMed
    7. Chin AR, Wang S. Cancer-derived extracellular vesicles: the 'soil conditioner' in breast cancer metastasis? Cancer Metastasis Rev. 2016 Dec; 35(4):669-676. PMID: 27838868.
      View in: PubMed
    8. Zhang K, Wu X, Wang J, Lopez J, Zhou W, Yang L, Wang S, Raz DJ, Kim JY. Circulating miRNA profile in esophageal adenocarcinoma. Am J Cancer Res. 2016; 6(11):2713-2721. PMID: 27904783.
      View in: PubMed
    9. Chin AR, Wang S. Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications. Clin Cancer Res. 2016 Aug 01; 22(15):3725-33. PMID: 27252414; PMCID: PMC4970897 [Available on 08/01/17].
    10. Chin AR, Fong MY, Somlo G, Wu J, Swiderski P, Wu X, Wang S. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res. 2016 Feb; 26(2):217-28. PMID: 26794868; PMCID: PMC4746606 [Available on 02/01/17].
    11. Fong MY, Zhou W, Liu L, Alontaga AY, Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR, Somlo G, Palomares M, Li Z, Tremblay JR, Tsuyada A, Sun G, Reid MA, Wu X, Swiderski P, Ren X, Shi Y, Kong M, Zhong W, Chen Y, Wang S. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015 Feb; 17(2):183-94. PMID: 25621950; PMCID: PMC4380143.
    12. Fong MY, Wang S. The exploits of cancer's greedy sweet-tooth. Cell Cycle. 2015; 14(12):1768-9. PMID: 25928026; PMCID: PMC4615071.
    13. Liu L, Zhou W, Cheng CT, Ren X, Somlo G, Fong MY, Chin AR, Li H, Yu Y, Xu Y, O'Connor ST, O'Connor TR, Ann DK, Stark JM, Wang S. TGFß induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes. Mol Cancer Res. 2014 Nov; 12(11):1597-609. PMID: 25103497; PMCID: PMC4233161.
    14. Chow A, Zhou W, Liu L, Fong MY, Champer J, Van Haute D, Chin AR, Ren X, Gugiu BG, Meng Z, Huang W, Ngo V, Kortylewski M, Wang S. Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-?B. Sci Rep. 2014 Jul 18; 4:5750. PMID: 25034888; PMCID: PMC4102923.
    15. Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, Yu Y, Chow A, O'Connor ST, Chin AR, Yen Y, Wang Y, Marcusson EG, Chu P, Wu J, Wu X, Li AX, Li Z, Gao H, Ren X, Boldin MP, Lin PC, Wang S. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014 Apr 14; 25(4):501-15. PMID: 24735924; PMCID: PMC4016197.
    16. Chin AR, Wang S. Cytokines driving breast cancer stemness. Mol Cell Endocrinol. 2014 Jan 25; 382(1):598-602. PMID: 23562748.
      View in: PubMed
    17. Zheng YW, Li H, Yu JP, Zhao H, Wang S, Ren XB. Interferon-?s: special immunomodulatory agents and potential therapeutic targets. J Innate Immun. 2013; 5(3):209-18. PMID: 23207147.
      View in: PubMed
    18. Li R, Wang C, Liu L, Du C, Cao S, Yu J, Wang S, Hao X, Ren X, Li H. Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study. Cancer Immunol Immunother. 2012 Nov; 61(11):2125-33. PMID: 22581306.
      View in: PubMed
    19. Tsuyada A, Chow A, Wu J, Somlo G, Chu P, Loera S, Luu T, Li AX, Wu X, Ye W, Chen S, Zhou W, Yu Y, Wang YZ, Ren X, Li H, Scherle P, Kuroki Y, Wang S. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 2012 Jun 01; 72(11):2768-79. PMID: 22472119; PMCID: PMC3367125.
    20. Chandra M, Zang S, Li H, Zimmerman LJ, Champer J, Tsuyada A, Chow A, Zhou W, Yu Y, Gao H, Ren X, Lin RJ, Wang S. Nuclear translocation of type I transforming growth factor ß receptor confers a novel function in RNA processing. Mol Cell Biol. 2012 Jun; 32(12):2183-95. PMID: 22473997; PMCID: PMC3372271.
    21. Wu X, Somlo G, Yu Y, Palomares MR, Li AX, Zhou W, Chow A, Yen Y, Rossi JJ, Gao H, Wang J, Yuan YC, Frankel P, Li S, Ashing-Giwa KT, Sun G, Wang Y, Smith R, Robinson K, Ren X, Wang S. De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J Transl Med. 2012 Mar 08; 10:42. PMID: 22400902; PMCID: PMC3342150.
    22. Zhang J, Li H, Yu JP, Wang S, Ren XB. Role of SOCS1 in tumor progression and therapeutic application. Int J Cancer. 2012 May 01; 130(9):1971-80. PMID: 22025331.
      View in: PubMed
    23. Yu J, Sun J, Wang S, Li H, Cao S, Cong Y, Liu J, Ren X. Upregulated expression of indoleamine 2, 3-dioxygenase in primary breast cancer correlates with increase of infiltrated regulatory T cells in situ and lymph node metastasis. Clin Dev Immunol. 2011; 2011:469135. PMID: 22110525; PMCID: PMC3202140.
    24. Chow A, Arteaga CL, Wang S. When tumor suppressor TGFß meets the HER2 (ERBB2) oncogene. J Mammary Gland Biol Neoplasia. 2011 Jun; 16(2):81-8. PMID: 21590373; PMCID: PMC3398103.
    25. Yu Y, Wang Y, Ren X, Tsuyada A, Li A, Liu LJ, Wang S. Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor ß contributes to chemoresistance in breast cancer cells. Mol Cancer Res. 2010 Dec; 8(12):1633-42. PMID: 21047769; PMCID: PMC3059495.
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