Our site may be slower due to heavy traffic from automated "bots" and AI crawlers. We're working to fix this.

Emily Wang

Photo of Emily Wang
Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailshw255@ucsd.edu
ORCID ORCID Icon0000-0002-5036-8175 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    Nankai UniversityPh.D.Virology
    University of Nebraska, LincolnPh.D. (joint)Virology
    Johns Hopkins Universitypost-docViral Oncology
    Vanderbilt Universitypost-docCancer Biology

    Collapse Overview 
    Collapse overview
    We study cancer as a whole-body-level disorder rather than a mass at the tissue or cellular level. Most cancers take years to develop, busy becoming ‘the fittest’ by adapting to the environment and––to a certain extent––altering the environment in the body. Our group has a long-standing interest in understanding the multifaceted interactions between tumor and host at the Molecular, Cellular, and Organ levels. We believe the cross-system effects of cancer will be a critical aspect in clinical care, to ensure that we not only remove the malignant lesion but also restore a healthy system to prevent recurrence and other diseases. We currently focus on mechanisms mediated by cancer-secreted extracellular vesicles and their microRNA and protein cargo, for their role in systemic manifestations and comorbidities of breast cancer such as metabolic diseases, cachexia, and neurological disorders.

    Collapse Research 
    Collapse research activities and funding
    Targeting Chemotherapy-induced Breast Cancer Stemness
    NIH/NCI R01CA206911Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Role of breast cancer-secreted miRNA in directing a stromal metabolic plasticity
    NIH/NCI R01CA218140Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Role of miR-105 in breast cancer metastasis
    NIH/NCI R01CA166020Sep 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Mechanism of chemoresistance mediated by TGF-beta
    NIH/NCI R01CA163586May 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
    NIH/NCI R00CA125892Jul 25, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Crosstalk TGFbeta and HER2 (ErbB2) Signaling in Mammary Tumorigenesis
    NIH/NCI K99CA125892Jul 25, 2007 - Jun 30, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis. Nat Commun. 2024 May 29; 15(1):4549. Ruan X, Yan W, Cao M, Daza RAM, Fong MY, Yang K, Wu J, Liu X, Palomares M, Wu X, Li A, Chen Y, Jandial R, Spitzer NC, Hevner RF, Wang SE. PMID: 38811525; PMCID: PMC11137082.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    2. Colocalization of protein and microRNA markers reveals unique extracellular vesicle subpopulations for early cancer detection. Sci Adv. 2024 03; 10(9):eadh8689. Li Z, Guo K, Gao Z, Chen J, Ye Z, Cao M, Wang SE, Yin Y, Zhong W. PMID: 38416840; PMCID: PMC10901469.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    3. Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis. Cancer Res Commun. 2024 01 22; 4(1):170-181. Wan Y, Zhao Y, Cao M, Wang J, Tran SV, Song Z, Hsueh BW, Wang SE. PMID: 38259097; PMCID: PMC10802141.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Multidimensional Widefield Infrared-Encoded Spontaneous Emission Microscopy: Distinguishing Chromophores by Ultrashort Infrared Pulses. J Am Chem Soc. 2024 Jan 24; 146(3):1874-1886. Yan C, Wang C, Wagner JC, Ren J, Lee C, Wan Y, Wang SE, Xiong W. PMID: 38085547; PMCID: PMC10811677.
      View in: PubMed   Mentions: 8     Fields:    
    5. Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle. EMBO Rep. 2023 09 06; 24(9):e56464. Ruan X, Cao M, Yan W, Jones YZ, Gustafsson ÅB, Patel HH, Schenk S, Wang SE. PMID: 37439436; PMCID: PMC10481655.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. A Mathematical Model of the Disruption of Glucose Homeostasis in Cancer Patients. Bull Math Biol. 2023 05 27; 85(7):58. Salentine N, Doria J, Nguyen C, Pinter G, Wang SE, Hinow P. PMID: 37243841; PMCID: PMC10435318.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Personal Health Libraries for People Returning From Incarceration: Protocol for a Qualitative Study. JMIR Res Protoc. 2023 May 03; 12:e44748. Foumakoye M, Britton MC, Ansari E, Saunders M, McCall T, Wang EA, Puglisi LB, Workman TE, Zeng-Treitler Q, Ying Y, Shavit S, Brandt CA, Wang KH. PMID: 37133907; PMCID: PMC10193212.
      View in: PubMed   Mentions: 2     Fields:    
    8. "We know what's going on in our community": A qualitative analysis identifying community assets that deter gun violence. SSM Qual Res Health. 2023 Jun; 3. Parsons A, Harvey TD, Andrade SD, Horton N, Brinkley-Rubenstein L, Wood G, Holaday LW, Riley C, Spell VT, Papachristos AV, Wang EA, Roy B. PMID: 37483654; PMCID: PMC10361409.
      View in: PubMed   Mentions: 4  
    9. Extracellular vesicles in cancer therapy. Semin Cancer Biol. 2022 11; 86(Pt 2):296-309. Wang SE. PMID: 35688334; PMCID: PMC10431950.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    10. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    11. Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis. Nat Cell Biol. 2022 05; 24(5):793-804. Yan W, Cao M, Ruan X, Jiang L, Lee S, Lemanek A, Ghassemian M, Pizzo DP, Wan Y, Qiao Y, Chin AR, Duggan E, Wang D, Nolan JP, Esko JD, Schenk S, Wang SE. PMID: 35469018; PMCID: PMC9107513.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    12. Calibration-free analysis of surface proteins on single extracellular vesicles enabled by DNA nanostructure. Biosens Bioelectron. 2021 Nov 15; 192:113502. Guo K, Li Z, Win A, Coreas R, Adkins GB, Cui X, Yan D, Cao M, Wang SE, Zhong W. PMID: 34298496; PMCID: PMC8580803.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    13. The Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support (TCN-PATHS): A hybrid type-1 effectiveness trial of enhanced primary care to improve opioid use disorder treatment outcomes following release from jail. J Subst Abuse Treat. 2021 09; 128:108315. Howell BA, Puglisi L, Clark K, Albizu-Garcia C, Ashkin E, Booth T, Brinkley-Rubinstein L, Fiellin DA, Fox AD, Maurer KF, Lin HJ, McCollister K, Murphy S, Morse DS, Shavit S, Wang K, Winkelman T, Wang EA. PMID: 33583610; PMCID: PMC8319218.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    14. Modeling the bidirectional glutamine/ammonium conversion between cancer cells and cancer-associated fibroblasts. PeerJ. 2021; 9:e10648. Hinow P, Pinter G, Yan W, Wang SE. PMID: 33520452; PMCID: PMC7811294.
      View in: PubMed   Mentions: 2     Fields:    
    15. Cancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis. EMBO Rep. 2021 02 03; 22(2):e51239. Fong MY, Yan W, Ghassemian M, Wu X, Zhou X, Cao M, Jiang L, Wang J, Liu X, Zhang J, Wang SE. PMID: 33345445; PMCID: PMC7857427.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    16. Extracellular Vesicles and Metastasis. Cold Spring Harb Perspect Med. 2020 07 01; 10(7). Wang SE. PMID: 31570387; PMCID: PMC7328450.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    17. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nat Cell Biol. 2019 11; 21(11):1403-1412. Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tešic Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D. PMID: 31685984; PMCID: PMC7354005.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    18. Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7 microRNA in macrophages. Proc Natl Acad Sci U S A. 2019 06 18; 116(25):12416-12421. Jiang S, Yan W, Wang SE, Baltimore D. PMID: 31160465; PMCID: PMC7056939.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    19. A Single Extracellular Vesicle (EV) Flow Cytometry Approach to Reveal EV Heterogeneity. Angew Chem Int Ed Engl. 2018 11 26; 57(48):15675-15680. Shen W, Guo K, Adkins GB, Jiang Q, Liu Y, Sedano S, Duan Y, Yan W, Wang SE, Bergersen K, Worth D, Wilson EH, Zhong W. PMID: 30291794; PMCID: PMC6246790.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    20. Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. Breast Cancer Res. 2018 10 22; 20(1):127. Liu X, Cao M, Palomares M, Wu X, Li A, Yan W, Fong MY, Chan WC, Wang SE. PMID: 30348200; PMCID: PMC6198446.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    21. Polarized Secretion of Extracellular Vesicles by Mammary Epithelia. J Mammary Gland Biol Neoplasia. 2018 09; 23(3):165-176. Chin AR, Yan W, Cao M, Liu X, Wang SE. PMID: 29968174; PMCID: PMC6103817.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    22. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018 05; 20(5):597-609. Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, Chen Y, Locasale JW, Wang SE. PMID: 29662176; PMCID: PMC5920728.
      View in: PubMed   Mentions: 288     Fields:    Translation:HumansAnimalsCells
    23. Chemotherapy Induces Breast Cancer Stemness in Association with Dysregulated Monocytosis. Clin Cancer Res. 2018 05 15; 24(10):2370-2382. Liu L, Yang L, Yan W, Zhai J, Pizzo DP, Chu P, Chin AR, Shen M, Dong C, Ruan X, Ren X, Somlo G, Wang SE. PMID: 29500278; PMCID: PMC5955855.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    24. Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients. Cell Metab. 2018 02 06; 27(2):393-403.e4. Jiang S, Yan W, Wang SE, Baltimore D. PMID: 29337138.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    25. Preparing for Disaster: a Cross-Sectional Study of Social Connection and Gun Violence. J Urban Health. 2017 10; 94(5):619-628. Riley C, Roy B, Harari N, Vashi A, Violano P, Greene A, Lucas G, Smart J, Hines T, Spell S, Taylor S, Tinney B, Williams M, Wang EA. PMID: 28116587; PMCID: PMC5610120.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    26. Cancer-derived extracellular vesicles: the 'soil conditioner' in breast cancer metastasis? Cancer Metastasis Rev. 2016 12; 35(4):669-676. Chin AR, Wang SE. PMID: 27838868; PMCID: PMC5831362.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    27. Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications. Clin Cancer Res. 2016 08 01; 22(15):3725-33. Chin AR, Wang SE. PMID: 27252414; PMCID: PMC4970897.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    28. Alcohol-Related Diagnoses and All-Cause Hospitalization Among HIV-Infected and Uninfected Patients: A Longitudinal Analysis of United States Veterans from 1997 to 2011. AIDS Behav. 2016 Mar; 20(3):555-64. Rentsch C, Tate JP, Akgün KM, Crystal S, Wang KH, Ryan Greysen S, Wang EA, Bryant KJ, Fiellin DA, Justice AC, Rimland D. PMID: 25711299; PMCID: PMC4550577.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    29. Erratum to: Alcohol-Related Diagnoses and All-Cause Hospitalization Among HIV-Infected and Uninfected Patients: A Longitudinal Analysis of United States Veterans from 1997 to 2011. AIDS Behav. 2016 Mar; 20(3):565. Rentsch C, Tate JP, Akgün KM, Crystal S, Wang KH, Ryan Greysen S, Wang EA, Bryant KJ, Fiellin DA, Justice AC, Rimland D. PMID: 25972072; PMCID: PMC5021303.
      View in: PubMed   Mentions:    Fields:    
    30. Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res. 2016 Feb; 26(2):217-28. Chin AR, Fong MY, Somlo G, Wu J, Swiderski P, Wu X, Wang SE. PMID: 26794868; PMCID: PMC4746606.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansAnimalsCells
    31. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015 Feb; 17(2):183-94. Fong MY, Zhou W, Liu L, Alontaga AY, Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR, Somlo G, Palomares M, Li Z, Tremblay JR, Tsuyada A, Sun G, Reid MA, Wu X, Swiderski P, Ren X, Shi Y, Kong M, Zhong W, Chen Y, Wang SE. PMID: 25621950; PMCID: PMC4380143.
      View in: PubMed   Mentions: 698     Fields:    Translation:HumansCells
    32. The exploits of cancer's greedy sweet-tooth. Cell Cycle. 2015; 14(12):1768-9. Fong MY, Wang SE. PMID: 25928026; PMCID: PMC4615071.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. TGFβ induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes. Mol Cancer Res. 2014 Nov; 12(11):1597-609. Liu L, Zhou W, Cheng CT, Ren X, Somlo G, Fong MY, Chin AR, Li H, Yu Y, Xu Y, O'Connor ST, O'Connor TR, Ann DK, Stark JM, Wang SE. PMID: 25103497; PMCID: PMC4233161.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    34. Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB. Sci Rep. 2014 Jul 18; 4:5750. Chow A, Zhou W, Liu L, Fong MY, Champer J, Van Haute D, Chin AR, Ren X, Gugiu BG, Meng Z, Huang W, Ngo V, Kortylewski M, Wang SE. PMID: 25034888; PMCID: PMC4102923.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    35. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014 Apr 14; 25(4):501-15. Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, Yu Y, Chow A, O'Connor ST, Chin AR, Yen Y, Wang Y, Marcusson EG, Chu P, Wu J, Wu X, Li AX, Li Z, Gao H, Ren X, Boldin MP, Lin PC, Wang SE. PMID: 24735924; PMCID: PMC4016197.
      View in: PubMed   Mentions: 892     Fields:    Translation:HumansCells
    36. Cytokines driving breast cancer stemness. Mol Cell Endocrinol. 2014 Jan 25; 382(1):598-602. Chin AR, Wang SE. PMID: 23562748.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    37. CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 2012 Jun 01; 72(11):2768-79. Tsuyada A, Chow A, Wu J, Somlo G, Chu P, Loera S, Luu T, Li AX, Wu X, Ye W, Chen S, Zhou W, Yu Y, Wang YZ, Ren X, Li H, Scherle P, Kuroki Y, Wang SE. PMID: 22472119; PMCID: PMC3367125.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansAnimalsCells
    38. De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer. J Transl Med. 2012 Mar 08; 10:42. Wu X, Somlo G, Yu Y, Palomares MR, Li AX, Zhou W, Chow A, Yen Y, Rossi JJ, Gao H, Wang J, Yuan YC, Frankel P, Li S, Ashing-Giwa KT, Sun G, Wang Y, Smith R, Robinson K, Ren X, Wang SE. PMID: 22400902; PMCID: PMC3342150.
      View in: PubMed   Mentions: 128     Fields:    Translation:Humans
    Emily's Networks
    Concepts (215)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (16)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-21-g9d46e6c4 on PROFILES-PWEB03. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California