Richard Daneman

Title(s)Associate Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    McGill University, Montreal, CanadaB.ScBiochemistry
    Stanford University, Stanford, CAPh.D.Developmental Biology
    Collapse Awards and Honors
    2017  - 2022Rita Allen Foundation Milton E. Cassel Scholar Award
    2017  - 2020Klingenstein Simons Fellowship Award in Neuroscience
    2013  - 2016Takeda Pharmaceuticals New Frontiers Sceince Awardee
    2015American Association of Anatomists Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Our goal is to understand the molecular mechanisms that regulate blood-brain barrier (BBB) function during health and disease. The BBB is a specialized structure formed by the blood vessels in the central nervous system (CNS) that is critical for proper brain function as well as protecting the brain from injury and disease. In most tissues the blood vessels are leaky allowing a relatively free flow of molecules and ions from blood into tissues, whereas in the brain, the blood vessels tightly restrict the movement of molecules and ions between the blood and the brain. This barrier clamps the extracellular environment allowing for proper neuronal communication while also limiting toxins, pathogens and even the body’s own immune system from entering and damaging the CNS. Breakdown of the BBB occurs during stroke, edema, brain trauma, and multiple sclerosis and is a major component of the symptoms and progression of these diseases. Furthermore, the BBB not only impedes the movement of toxins and pathogens, but also inhibits the delivery of potential therapeutic agents to the CNS.

    We use a combination of cellular, molecular and genetic approaches to understand the mechanisms of BBB formation and function. We are interested in asking:
    What are the molecules in CNS vascular cells that form the BBB?
    What are the mechanisms that lead to BBB disruption during disease?
    How does the BBB regulate brain function and behavior?

    The goal of our work is to elucidate these mechanisms, such that we will be able to develop therapeutics to rebuild the barrier to treat neurological diseases, as well as methods to bypass the barrier to deliver drugs to the CNS.

    Collapse Research 
    Collapse Research Activities and Funding
    How do CNS fibroblasts regulate the response to neuroinflammation?
    NIH R01NS119615Jan 1, 2021 - Dec 31, 2025
    Role: Principal Investigator
    Microglial regulation of cerebrovascular cholesterol metabolism: implications forAlzheimers disease
    NIH R21AG067035Sep 11, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Blood-brain barrier monoamine metabolism regulation of social behavior
    NIH R01MH121761Jun 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Examining the role of perivascular fibroblasts in cerebral amyloid angiopathy during Alzheimers disease
    NIH R21AG062918Apr 1, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Milton E. Cassel Award
    Rita Allen Foundation Sep 1, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Klingenstein-Simons Fellowship Award in Neuroscience
    Klingenstein Foundation Jul 1, 2017 - Jun 30, 2020
    Mechanisms of blood-brain barrier disruption during neuroinflammation
    NMSS RG-1501-02549Oct 1, 2015 - Sep 30, 2018
    Role: Principal Investigator
    Regulation of blood-brain barrier formation and function by EHDs
    NIH R01NS091281Sep 30, 2015 - Jul 31, 2021
    Role: Principal Investigator
    RXRalpha and PPARdelta Signaling as Novel Regulators of the Blood-Brain Barrier
    NIH 1R01NS083688-01Jun 1, 2013 - May 31, 2018
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism. Neuron. 2024 Sep 04; 112(17):2910-2921.e7. Profaci CP, Harvey SS, Bajc K, Zhang TZ, Jeffrey DA, Zhang AZ, Nemec KM, Davtyan H, O'Brien CA, McKinsey GL, Longworth A, McMullen TP, Capocchi JK, Gonzalez JG, Lawson DA, Arnold TD, Davalos D, Blurton-Jones M, Dabertrand F, Bennett FC, Daneman R. PMID: 39142282; PMCID: PMC11446403.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CX3CR1-CX3CL1 Signaling. Arterioscler Thromb Vasc Biol. 2024 06; 44(6):1246-1264. Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai CC, Orecchioni M, Sriram A, Bui CM, Nelsen B, Hale P, Pham A, Shenkar R, DeBiasse D, Lightle R, Girard R, Li Y, Srinath A, Daneman R, Nudleman E, Sun H, Guma M, Dubrac A, Mesarwi OA, Ley K, Kim H, Awad IA, Ginsberg MH, Lopez-Ramirez MA. PMID: 38660801; PMCID: PMC11111348.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown. bioRxiv. 2024 Apr 14. Lawrence JH, Patel A, King MW, Nadarajah CJ, Daneman R, Musiek ES. PMID: 38645230; PMCID: PMC11030435.
      View in: PubMed   Mentions:
    4. Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest. Sci Adv. 2024 Feb 02; 10(5):eadi1737. Gastfriend BD, Snyder ME, Holt HE, Daneman R, Palecek SP, Shusta EV. PMID: 38306433; PMCID: PMC10836734.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Dural mural cells paint an anti-inflammatory picture. J Exp Med. 2024 Feb 05; 221(2). Lummis NC, Gastfriend BD, Daneman R. PMID: 38270593; PMCID: PMC10818063.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Author Correction: CD98hc is a target for brain delivery of biotherapeutics. Nat Commun. 2023 Sep 07; 14(1):5516. Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, Akkapeddi P, Annamalai L, Bajc K, Blanchette M, Cherf GM, Earr TK, Gill A, Huynh D, Joy D, Knight KN, Lac D, Leung AW, Lexa KW, Liau NPD, Becerra I, Malfavon M, McInnes J, Nguyen HN, Lozano EI, Pizzo ME, Roche E, Sacayon P, Calvert MEK, Daneman R, Dennis MS, Duque J, Gadkar K, Lewcock JW, Mahon CS, Meisner R, Solanoy H, Thorne RG, Watts RJ, Zuchero YJY, Kariolis MS. PMID: 37679403; PMCID: PMC10484993.
      View in: PubMed   Mentions:    Fields:    
    7. CD98hc is a target for brain delivery of biotherapeutics. Nat Commun. 2023 08 19; 14(1):5053. Chew KS, Wells RC, Moshkforoush A, Chan D, Lechtenberg KJ, Tran HL, Chow J, Kim DJ, Robles-Colmenares Y, Srivastava DB, Tong RK, Tong M, Xa K, Yang A, Zhou Y, Akkapeddi P, Annamalai L, Bajc K, Blanchette M, Cherf GM, Earr TK, Gill A, Huynh D, Joy D, Knight KN, Lac D, Leung AW, Lexa KW, Liau NPD, Becerra I, Malfavon M, McInnes J, Nguyen HN, Lozano EI, Pizzo ME, Roche E, Sacayon P, Calvert MEK, Daneman R, Dennis MS, Duque J, Gadkar K, Lewcock JW, Mahon CS, Meisner R, Solanoy H, Thorne RG, Watts RJ, Zuchero YJY, Kariolis MS. PMID: 37598178; PMCID: PMC10439950.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Editorial: Brain arteriovenous malformations: cerebrovasculature behaving badly. Front Hum Neurosci. 2023; 17:1212184. Shoemaker LD, Daneman R, Stoodley MA. PMID: 37351364; PMCID: PMC10282935.
      View in: PubMed   Mentions:
    9. Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege. J Clin Invest. 2023 05 01; 133(9). Ma Y, Sannino D, Linden JR, Haigh S, Zhao B, Grigg JB, Zumbo P, Dündar F, Butler D, Profaci CP, Telesford K, Winokur PN, Rumah KR, Gauthier SA, Fischetti VA, McClane BA, Uzal FA, Zexter L, Mazzucco M, Rudick R, Danko D, Balmuth E, Nealon N, Perumal J, Kaunzner U, Brito IL, Chen Z, Xiang JZ, Betel D, Daneman R, Sonnenberg GF, Mason CE, Vartanian T. PMID: 36853799; PMCID: PMC10145940.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 Oct; 610(7930):E1. Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M. PMID: 36131025.
      View in: PubMed   Mentions: 1     Fields:    
    11. Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 04; 604(7907):740-748. Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernández-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lämmermann T, Priller J, Kierdorf K, Prinz M. PMID: 35444273.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    12. Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science. 2022 02 18; 375(6582):eabm4459. Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d'Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. PMID: 35175798.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    13. Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging. J Cereb Blood Flow Metab. 2022 06; 42(6):966-978. Bonney SK, Sullivan LT, Cherry TJ, Daneman R, Shih AY. PMID: 34929105; PMCID: PMC9125487.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    14. Emerging roles for CNS fibroblasts in health, injury and disease. Nat Rev Neurosci. 2022 01; 23(1):23-34. Dorrier CE, Jones HE, Pintaric L, Siegenthaler JA, Daneman R. PMID: 34671105; PMCID: PMC8527980.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    15. Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest. 2021 07 01; 131(13). Lopez-Ramirez MA, Lai CC, Soliman SI, Hale P, Pham A, Estrada EJ, McCurdy S, Girard R, Verma R, Moore T, Lightle R, Hobson N, Shenkar R, Poulsen O, Haddad GG, Daneman R, Gongol B, Sun H, Lagarrigue F, Awad IA, Ginsberg MH. PMID: 34043589; PMCID: PMC8245174.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    16. CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nat Neurosci. 2021 02; 24(2):234-244. Dorrier CE, Aran D, Haenelt EA, Sheehy RN, Hoi KK, Pintaric L, Chen Y, Lizama CO, Cautivo KM, Weiner GA, Popko B, Fancy SPJ, Arnold TD, Daneman R. PMID: 33526922; PMCID: PMC7877789.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    17. Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes. Neuron. 2020 12 09; 108(5):937-952.e7. Pulido RS, Munji RN, Chan TC, Quirk CR, Weiner GA, Weger BD, Rossi MJ, Elmsaouri S, Malfavon M, Deng A, Profaci CP, Blanchette M, Qian T, Foreman KL, Shusta EV, Gorman MR, Gachon F, Leutgeb S, Daneman R. PMID: 32979312; PMCID: PMC7736535.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    18. Multidimensional Proteome Profiling of Blood-Brain Barrier Perturbation by Group B Streptococcus. mSystems. 2020 Aug 25; 5(4). Campeau A, Mills RH, Blanchette M, Bajc K, Malfavon M, Munji RN, Deng L, Hancock B, Patras KA, Olson J, Nizet V, Daneman R, Doran K, Gonzalez DJ. PMID: 32843537; PMCID: PMC7449606.
      View in: PubMed   Mentions: 3     Fields:    
    19. Unexpected amount of blood-borne protein enters the young brain. Nature. 2020 07; 583(7816):362-363. Munji RN, Daneman R. PMID: 32661413.
      View in: PubMed   Mentions: 3     Fields:    
    20. The blood-brain barrier in health and disease: Important unanswered questions. J Exp Med. 2020 04 06; 217(4). Profaci CP, Munji RN, Pulido RS, Daneman R. PMID: 32211826; PMCID: PMC7144528.
      View in: PubMed   Mentions: 236     Fields:    Translation:HumansAnimals
    21. Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids. PLoS One. 2019; 14(11):e0225206. Huang Q, Chan KY, Tobey IG, Chan YA, Poterba T, Boutros CL, Balazs AB, Daneman R, Bloom JM, Seed C, Deverman BE. PMID: 31725765; PMCID: PMC6855452.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    22. Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module. Nat Neurosci. 2019 11; 22(11):1892-1902. Munji RN, Soung AL, Weiner GA, Sohet F, Semple BD, Trivedi A, Gimlin K, Kotoda M, Korai M, Aydin S, Batugal A, Cabangcala AC, Schupp PG, Oldham MC, Hashimoto T, Noble-Haeusslein LJ, Daneman R. PMID: 31611708; PMCID: PMC6858546.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    23. Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation. Nat Commun. 2019 06 06; 10(1):2477. Weiner GA, Shah SH, Angelopoulos CM, Bartakova AB, Pulido RS, Murphy A, Nudleman E, Daneman R, Goldberg JL. PMID: 31171770; PMCID: PMC6554348.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties. Sci Adv. 2019 03; 5(3):eaau7375. Stebbins MJ, Gastfriend BD, Canfield SG, Lee MS, Richards D, Faubion MG, Li WJ, Daneman R, Palecek SP, Shusta EV. PMID: 30891496; PMCID: PMC6415958.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    25. The amazing brain drain. J Exp Med. 2017 12 04; 214(12):3469-3470. Blanchette M, Daneman R. PMID: 29162645; PMCID: PMC5716048.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Corrigendum: Purification of Endothelial Cells from Rodent Brain by Immunopanning. Cold Spring Harb Protoc. 2017 11 01; 2017(11). Zhou L, Sohet F, Daneman R. PMID: 29093198.
      View in: PubMed   Mentions:    Fields:    
    27. Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior. Cell Rep. 2017 Oct 31; 21(5):1304-1316. Hindle SJ, Munji RN, Dolghih E, Gaskins G, Orng S, Ishimoto H, Soung A, DeSalvo M, Kitamoto T, Keiser MJ, Jacobson MP, Daneman R, Bainton RJ. PMID: 29091768; PMCID: PMC5774027.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    28. Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells. Biotechnol J. 2018 Feb; 13(2). Stebbins MJ, Lippmann ES, Faubion MG, Daneman R, Palecek SP, Shusta EV. PMID: 28960887; PMCID: PMC5796863.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    29. Brain barriers in health and disease. Neurobiol Dis. 2017 11; 107:1-3. Daneman R, Engelhardt B. PMID: 28552387.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    30. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J. 2017 08; 31(8):3689-3694. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. PMID: 28476896; PMCID: PMC5503715.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    31. A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism. Mol Ther. 2017 07 05; 25(7):1531-1543. Meng Y, Wiseman JA, Nemtsova Y, Moore DF, Guevarra J, Reuhl K, Banks WA, Daneman R, Sleat DE, Lobel P. PMID: 28456380; PMCID: PMC5498811.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. Finding NMO. Neurol Neuroimmunol Neuroinflamm. 2017 Jan; 4(1):e313. Daneman R. PMID: 28018944; PMCID: PMC5173348.
      View in: PubMed   Mentions: 2     Fields:    
    33. Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE. Exp Neurol. 2016 09; 283(Pt A):224-34. Frezel N, Sohet F, Daneman R, Basbaum AI, Braz JM. PMID: 27343802; PMCID: PMC5500277.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    34. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science. 2016 Jan 22; 351(6271):379-84. Tsai HH, Niu J, Munji R, Davalos D, Chang J, Zhang H, Tien AC, Kuo CJ, Chan JR, Daneman R, Fancy SP. PMID: 26798014; PMCID: PMC5472053.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimalsCells
    35. PDGFRβ(+) cells in human and experimental neuro-vascular dysplasia and seizures. Neuroscience. 2015 Oct 15; 306:18-27. Garbelli R, de Bock F, Medici V, Rousset MC, Villani F, Boussadia B, Arango-Lievano M, Jeanneteau F, Daneman R, Bartolomei F, Marchi N. PMID: 26283024.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    36. Formation and maintenance of the BBB. Mech Dev. 2015 Nov; 138 Pt 1:8-16. Blanchette M, Daneman R. PMID: 26215350.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    37. LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. J Cell Biol. 2015 Mar 16; 208(6):703-11. Sohet F, Lin C, Munji RN, Lee SY, Ruderisch N, Soung A, Arnold TD, Derugin N, Vexler ZS, Yen FT, Daneman R. PMID: 25753034; PMCID: PMC4362448.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    38. The blood-brain barrier. Cold Spring Harb Perspect Biol. 2015 Jan 05; 7(1):a020412. Daneman R, Prat A. PMID: 25561720; PMCID: PMC4292164.
      View in: PubMed   Mentions: 1249     Fields:    Translation:HumansCells
    39. Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier. PLoS Pathog. 2014 Dec; 10(12):e1004528. Nacer A, Movila A, Sohet F, Girgis NM, Gundra UM, Loke P, Daneman R, Frevert U. PMID: 25474413; PMCID: PMC4256476.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    40. Dissecting gene expression at the blood-brain barrier. Front Neurosci. 2014; 8:355. Huntley MA, Bien-Ly N, Daneman R, Watts RJ. PMID: 25414634; PMCID: PMC4222230.
      View in: PubMed   Mentions: 22  
    41. High endothelial venules through a transcriptomics lens. Nat Immunol. 2014 Oct; 15(10):906-8. Rosen SD, Daneman R. PMID: 25232814.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    42. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci. 2014 Sep 03; 34(36):11929-47. Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ. PMID: 25186741; PMCID: PMC4152602.
      View in: PubMed   Mentions: 2606     Fields:    Translation:AnimalsCells
    43. Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell. 2014 Jul 17; 158(2):383-396. Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH. PMID: 25018103; PMCID: PMC4149873.
      View in: PubMed   Mentions: 192     Fields:    Translation:AnimalsCells
    44. Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones. Invest Ophthalmol Vis Sci. 2014 Jun 06; 55(7):4369-77. Steketee MB, Oboudiyat C, Daneman R, Trakhtenberg E, Lamoureux P, Weinstein JE, Heidemann S, Barres BA, Goldberg JL. PMID: 24906860; PMCID: PMC4102390.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    45. Purification and culture of central nervous system pericytes. Cold Spring Harb Protoc. 2014 Jun 02; 2014(6):581-3. Zhou L, Sohet F, Daneman R. PMID: 24890216.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    46. Purification of pericytes from rodent optic nerve by immunopanning. Cold Spring Harb Protoc. 2014 Jun 02; 2014(6):608-17. Zhou L, Sohet F, Daneman R. PMID: 24890207.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    47. Purification and culture of central nervous system endothelial cells. Cold Spring Harb Protoc. 2014 Jan 01; 2014(1):44-6. Zhou L, Sohet F, Daneman R. PMID: 24371313.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    48. Purification of endothelial cells from rodent brain by immunopanning. Cold Spring Harb Protoc. 2014 Jan 01; 2014(1):65-77. Zhou L, Sohet F, Daneman R. PMID: 24371317.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    49. Development, maintenance and disruption of the blood-brain barrier. Nat Med. 2013 Dec; 19(12):1584-96. Obermeier B, Daneman R, Ransohoff RM. PMID: 24309662; PMCID: PMC4080800.
      View in: PubMed   Mentions: 986     Fields:    Translation:HumansAnimalsCells
    50. 'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis. Curr Opin Neurobiol. 2013 Dec; 23(6):1057-64. Siegenthaler JA, Sohet F, Daneman R. PMID: 23867075; PMCID: PMC4061913.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    51. Foxc1 is required by pericytes during fetal brain angiogenesis. Biol Open. 2013 Jul 15; 2(7):647-59. Siegenthaler JA, Choe Y, Patterson KP, Hsieh I, Li D, Jaminet SC, Daneman R, Kume T, Huang EJ, Pleasure SJ. PMID: 23862012; PMCID: PMC3711032.
      View in: PubMed   Mentions: 38     Fields:    
    52. Transporters of the blood-brain and blood-CSF interfaces in development and in the adult. Mol Aspects Med. 2013 Apr-Jun; 34(2-3):742-52. Saunders NR, Daneman R, Dziegielewska KM, Liddelow SA. PMID: 23506907.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    53. Genetic mouse models to study blood-brain barrier development and function. Fluids Barriers CNS. 2013 Jan 10; 10(1):3. Sohet F, Daneman R. PMID: 23305182; PMCID: PMC3675378.
      View in: PubMed   Mentions: 17     Fields:    
    54. The blood-brain barrier in health and disease. Ann Neurol. 2012 Nov; 72(5):648-72. Daneman R. PMID: 23280789.
      View in: PubMed   Mentions: 251     Fields:    Translation:Humans
    55. Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. J Neurosci. 2012 Jul 11; 32(28):9588-600. Fernández-López D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler ZS. PMID: 22787045; PMCID: PMC3539825.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    56. Development of a method for the purification and culture of rodent astrocytes. Neuron. 2011 Sep 08; 71(5):799-811. Foo LC, Allen NJ, Bushong EA, Ventura PB, Chung WS, Zhou L, Cahoy JD, Daneman R, Zong H, Ellisman MH, Barres BA. PMID: 21903074; PMCID: PMC3172573.
      View in: PubMed   Mentions: 214     Fields:    Translation:AnimalsCells
    57. Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis. J Clin Immunol. 2011 Dec; 31(6):1010-20. Crespo O, Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH. PMID: 21847523; PMCID: PMC3225802.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    58. The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS One. 2010 Oct 29; 5(10):e13741. Daneman R, Zhou L, Agalliu D, Cahoy JD, Kaushal A, Barres BA. PMID: 21060791; PMCID: PMC2966423.
      View in: PubMed   Mentions: 297     Fields:    Translation:Animals
    59. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010 Nov 25; 468(7323):562-6. Daneman R, Zhou L, Kebede AA, Barres BA. PMID: 20944625; PMCID: PMC3241506.
      View in: PubMed   Mentions: 1012     Fields:    Translation:AnimalsCells
    60. The gut immune barrier and the blood-brain barrier: are they so different? Immunity. 2009 Nov 20; 31(5):722-35. Daneman R, Rescigno M. PMID: 19836264.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    61. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):641-6. Daneman R, Agalliu D, Zhou L, Kuhnert F, Kuo CJ, Barres BA. PMID: 19129494; PMCID: PMC2626756.
      View in: PubMed   Mentions: 387     Fields:    Translation:AnimalsCells
    62. A novel purification method for CNS projection neurons leads to the identification of brain vascular cells as a source of trophic support for corticospinal motor neurons. J Neurosci. 2008 Aug 13; 28(33):8294-305. Dugas JC, Mandemakers W, Rogers M, Ibrahim A, Daneman R, Barres BA. PMID: 18701692; PMCID: PMC2567869.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    63. The blood-brain barrier--lessons from moody flies. Cell. 2005 Oct 07; 123(1):9-12. Daneman R, Barres BA. PMID: 16213208.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    64. A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15050-5. Morin X, Daneman R, Zavortink M, Chia W. PMID: 11742088; PMCID: PMC64981.
      View in: PubMed   Mentions: 433     Fields:    Translation:AnimalsCells
    65. In situ measurements of the pH of mammalian peroxisomes using the fluorescent protein pHluorin. J Biol Chem. 2001 Dec 28; 276(52):48748-53. Jankowski A, Kim JH, Collins RF, Daneman R, Walton P, Grinstein S. PMID: 11641408.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    66. Discrepancy between CYP2D6 phenotype and genotype derived from post-mortem dextromethorphan blood level. Forensic Sci Int. 2000 May 08; 110(1):61-70. Bailey B, Daneman R, Daneman N, Mayer JM, Koren G. PMID: 10802201.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    67. The efficacy of diazepam in the treatment of acute iron overload in rats. Can J Physiol Pharmacol. 1998 Sep; 76(9):895-9. Fassos FF, Berkovitch M, Daneman N, Koren L, Cameron R, Klein J, Falcitelli C, St Louis P, Daneman R, Koren G. PMID: 10066140.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    68. Noninvasive measurement of the pH of the endoplasmic reticulum at rest and during calcium release. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2997-3002. Kim JH, Johannes L, Goud B, Antony C, Lingwood CA, Daneman R, Grinstein S. PMID: 9501204; PMCID: PMC19683.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    69. Interactions of clobazam with conventional antiepileptics in children. J Child Neurol. 1997 Apr; 12(3):208-13. Theis JG, Koren G, Daneman R, Sherwin AL, Menzano E, Cortez M, Hwang P. PMID: 9130097.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    70. Efficacy of deferiprone in the treatment of acute iron intoxication in rats. J Toxicol Clin Toxicol. 1996; 34(3):279-87. Fassos FF, Berkovitch M, Daneman N, Koren L, Cameron RG, Klein J, Falcitelli C, St Louis P, Daneman R, Koren G. PMID: 8667465.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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