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Marcos Intaglietta

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentBioengineering
Address9500 Gilman Drive #0412
La Jolla CA 92093
Phone858-534-4275
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    Collapse Research 
    Collapse Research Activities and Funding
    MECHANISMS AND MODULATION OF ACCELLULAR HbA TOXICITY
    NIH P01HL110900Aug 1, 2012 - Jul 31, 2017
    Role: Co-Investigator
    Integrative Bioengineering of Heart, Vessels, and Blood
    NIH/NHLBI T32HL105373Sep 20, 2010 - Aug 31, 2020
    Role: Principal Investigator
    Anti-Inflamatory Coatings for Biomaterials
    NIH R01EB000823Aug 15, 2002 - Jul 31, 2008
    Role: Co-Investigator
    New Paradigms in the Design of Blood Substitutes
    NIH P01HL071064Aug 5, 2002 - Jul 31, 2008
    Role: Co-Investigator
    FUNCTIONAL ASPECTS OF OXYGEN DELIVERY
    NIH/NHLBI R01HL062318Jun 22, 2001 - Apr 30, 2007
    Role: Principal Investigator
    Transfusion Trigger Extension by Plasma Expanders
    NIH/NHLBI R01HL062354Sep 1, 2000 - Jul 31, 2011
    Role: Principal Investigator
    Bioengineering Design of Artificial Blood
    NIH/NHLBI R01HL064395May 5, 2000 - Jul 31, 2013
    Role: Principal Investigator
    BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    NIH/NHLBI R24HL064395May 5, 2000 - Apr 30, 2007
    Role: Principal Investigator
    BLOOD SUBSTITUTES--MOLECULAR AND PHYSIOLOGICAL ASPECTS
    NIH P01HL048018Sep 1, 1993 - Aug 31, 1998
    Role: Co-Investigator
    BIOENGINEERING ANALYSIS OF MICROVASCULAR FUNCTION
    NIH/NHLBI R01HL012493May 1, 1975 - Mar 31, 1991
    Role: Principal Investigator
    REGULATION AND EXCHANGE IN THE MICROCIRCULATION
    NIH P01HL017421Sep 1, 1974 - Aug 31, 1995
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sugie J, Intaglietta M, Sung LA. Water transport and homeostasis as a major function of erythrocytes. Am J Physiol Heart Circ Physiol. 2018 May 01; 314(5):H1098-H1107. PMID: 29393658.
      View in: PubMed
    2. Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58(1):255-266. PMID: 29243830.
      View in: PubMed
    3. Zimmerman R, Tsai AG, Salazar Vázquez BY, Cabrales P, Hofmann A, Meier J, Shander A, Spahn DR, Friedman JM, Tartakovsky DM, Intaglietta M. Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity. Anesth Analg. 2017 05; 124(5):1547-1554. PMID: 28328758.
      View in: PubMed
    4. Chávez-Negrete AJ, Rojas-Uribe M, Gallardo-Montoya JM, Intaglietta M. Hemorrheologic effect of diuretics in the control of blood pressure in the hypertensive patient Rev Med Inst Mex Seguro Soc. 2017; 55(Suppl 4):S343-S349. PMID: 29791790.
      View in: PubMed
    5. Martucci AF, Abreu Martucci AC, Cabrales P, Nascimento PD, Intaglietta M, Tsai AG, Castiglia YM. Acute kidney function and morphology following topload administration of recombinant hemoglobin solution. Artif Cells Nanomed Biotechnol. 2017 Feb; 45(1):24-30. PMID: 27797281.
      View in: PubMed
    6. Park SW, Intaglietta M, Tartakovsky DM. Impact of stochastic fluctuations in the cell free layer on nitric oxide bioavailability. Front Comput Neurosci. 2015; 9:131. PMID: 26578944; PMCID: PMC4621848.
    7. Tsai AG, Vázquez BY, Hofmann A, Acharya SA, Intaglietta M. Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions? J Infus Nurs. 2015 May-Jun; 38(3):217-22. PMID: 25871869.
      View in: PubMed
    8. Tsai AG, Salazar Vázquez BY, Cabrales P, Kistler EB, Tartakovsky DM, Subramaniam S, Acharya SA, Intaglietta M. Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies. J Funct Biomater. 2014 Oct 27; 5(4):232-45. PMID: 25350267; PMCID: PMC4285404.
    9. Sriram K, Intaglietta M, Tartakovsky DM. Non-Newtonian flow of blood in arterioles: consequences for wall shear stress measurements. Microcirculation. 2014 Oct; 21(7):628-39. PMID: 24703006; PMCID: PMC4185264.
    10. Sriram K, Intaglietta M, Tartakovsky DM. Hematocrit dispersion in asymmetrically bifurcating vascular networks. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1576-86. PMID: 25217657; PMCID: PMC4255010.
    11. Tsai AG, Cabrales P, Young MA, Winslow RM, Intaglietta M. Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia. Artif Cells Nanomed Biotechnol. 2015 Feb; 43(1):10-7. PMID: 25060721.
      View in: PubMed
    12. Salazar Vázquez BY, Salazar Vázquez MA, Chávez-Negrete A, Escobedo G, Cabrales P, Subramaniam S, Intaglietta M, Pérez-Tamayo R. Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women. Vasc Health Risk Manag. 2014; 10:271-7. PMID: 24851053; PMCID: PMC4018417.
    13. Palmer AF, Intaglietta M. Blood substitutes. Annu Rev Biomed Eng. 2014 Jul 11; 16:77-101. PMID: 24819476.
      View in: PubMed
    14. Meng F, Tsai AG, Intaglietta M, Acharya SA. PEGylation of aa-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG aa-Hbs. Artif Cells Nanomed Biotechnol. 2015; 43(4):270-81. PMID: 24597567; PMCID: PMC4167218.
    15. Martini J, Cabrales P, Fries D, Intaglietta M, Tsai AG. Effects of fibrinogen concentrate after shock/resuscitation: a comparison between in vivo microvascular clot formation and thromboelastometry*. Crit Care Med. 2013 Nov; 41(11):e301-8. PMID: 23978812; PMCID: PMC4109711.
    16. Cabrales P, Intaglietta M. Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids. ASAIO J. 2013 Jul-Aug; 59(4):337-54. PMID: 23820271; PMCID: PMC3703868.
    17. Salazar Vázquez BY, Hightower CM, Yalcin O, Acharya SA, Intaglietta M. Semisynthetic hybrid biopolymers for non-pharmacological intervention of the microcirculation. Curr Drug Metab. 2013 Jun; 14(5):540-6. PMID: 23687928.
      View in: PubMed
    18. Saltzman DJ, Kerger H, Jimenez JC, Farzan D, Wilson JM, Thompson JE, Intaglietta M. Microvascular changes following four-hour single arteriole occlusion. Microsurgery. 2013 Mar; 33(3):207-15. PMID: 23152084.
      View in: PubMed
    19. Tsai AG, Intaglietta M, Sakai H, Delpy E, La Rochelle CD, Rousselot M, Zal F. Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier. Curr Drug Discov Technol. 2012 Sep; 9(3):166-72. PMID: 22564165.
      View in: PubMed
    20. Sriram K, Salazar Vázquez BY, Tsai AG, Cabrales P, Intaglietta M, Tartakovsky DM. Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1096-106. PMID: 22923620; PMCID: PMC3517642.
    21. Hightower CM, Salazar Vázquez BY, Acharya SA, Subramaniam S, Intaglietta M. PEG-albumin plasma expansion increases expression of MCP-1 evidencing increased circulatory wall shear stress: an experimental study. PLoS One. 2012; 7(6):e39111. PMID: 22720043; PMCID: PMC3375248.
    22. Hightower CM, Salazar Vázquez BY, Cabrales P, Tsai AG, Acharya SA, Intaglietta M. Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage. Transfusion. 2013 Jan; 53(1):49-59. PMID: 22554380; PMCID: PMC4517570.
    23. Sriram K, Tsai AG, Cabrales P, Meng F, Acharya SA, Tartakovsky DM, Intaglietta M. PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning. Am J Physiol Heart Circ Physiol. 2012 Jun 15; 302(12):H2489-97. PMID: 22505638; PMCID: PMC3378262.
    24. Park SW, Intaglietta M, Tartakovsky DM. Impact of endothelium roughness on blood flow. J Theor Biol. 2012 May 07; 300:152-60. PMID: 22300799; PMCID: PMC3307844.
    25. Messmer C, Cabrales P, Intaglietta M. Effects of acute anemia and hyperoxia on oxygen distribution. Adv Exp Med Biol. 2012; 737:213-8. PMID: 22259104; PMCID: PMC4105298.
    26. Villela NR, Tsai AG, Cabrales P, Intaglietta M. Improved resuscitation from hemorrhagic shock with Ringer's lactate with increased viscosity in the hamster window chamber model. J Trauma. 2011 Aug; 71(2):418-24. PMID: 21248647.
      View in: PubMed
    27. Hightower JD, Hightower CM, Vázquez BY, Intaglietta M. Incident prediabetes/diabetes and blood pressure in urban and rural communities in the Democratic Republic of Congo. Vasc Health Risk Manag. 2011; 7:483-9. PMID: 21822396; PMCID: PMC3148422.
    28. Vázquez BY, Hightower CM, Martini J, Messmer C, Frienesenecker B, Corbels P, Tsai AG, Intaglietta M. Vasoactive hemoglobin solution improves survival in hemodilution followed by hemorrhagic shock. Crit Care Med. 2011 Jun; 39(6):1461-6. PMID: 21336111; PMCID: PMC3318980.
    29. Ananda K, Manjula BN, Meng F, Acharya VN, Intaglietta M, Acharya SA. Packing density of the PEG-shell in PEG-albumins: PEGylation induced viscosity and COP are inverse correlate of packing density. Artif Cells Blood Substit Immobil Biotechnol. 2012 Feb; 40(1-2):14-27. PMID: 21623695.
      View in: PubMed
    30. Hightower CM, Salazar Vázquez BY, Woo Park S, Sriram K, Martini J, Yalcin O, Tsai AG, Cabrales P, Tartakovsky DM, Johnson PC, Intaglietta M. Integration of cardiovascular regulation by the blood/endothelium cell-free layer. Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug; 3(4):458-70. PMID: 21523919.
      View in: PubMed
    31. Hightower CM, Yalcin O, Vázquez BY, Johnson PC, Intaglietta M. Effect of plasma expander viscosity on the cell free layer. Biorheology. 2011; 48(2):115-25. PMID: 21811016.
      View in: PubMed
    32. Salazar Vázquez BY, Cabrales P, Tsai AG, Intaglietta M. Nonlinear cardiovascular regulation consequent to changes in blood viscosity. Clin Hemorheol Microcirc. 2011; 49(1-4):29-36. PMID: 22214675.
      View in: PubMed
    33. Branigan T, Bolster D, Vázquez BY, Intaglietta M, Tartakovsky DM. Mean arterial pressure nonlinearity in an elastic circulatory system subjected to different hematocrits. Biomech Model Mechanobiol. 2011 Jul; 10(4):591-8. PMID: 20878440.
      View in: PubMed
    34. Sriram K, Vázquez BY, Yalcin O, Johnson PC, Intaglietta M, Tartakovsky DM. The effect of small changes in hematocrit on nitric oxide transport in arterioles. Antioxid Redox Signal. 2011 Jan 15; 14(2):175-85. PMID: 20560785; PMCID: PMC3014765.
    35. Vázquez BY, Martini J, Tsai AG, Johnson PC, Cabrales P, Intaglietta M. The variability of blood pressure due to small changes of hematocrit. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H863-7. PMID: 20601464; PMCID: PMC2944491.
    36. Tsai AG, Hofmann A, Cabrales P, Intaglietta M. Perfusion vs. oxygen delivery in transfusion with "fresh" and "old" red blood cells: the experimental evidence. Transfus Apher Sci. 2010 Aug; 43(1):69-78. PMID: 20646963; PMCID: PMC2918661.
    37. Sapuppo F, Llobera A, Schembri F, Intaglietta M, Cadarso VJ, Bucolo M. A polymeric micro-optical interface for flow monitoring in biomicrofluidics. Biomicrofluidics. 2010 May 24; 4(2). PMID: 20697581; PMCID: PMC2917872.
    38. Tsai AG, Cabrales P, Intaglietta M. The physics of oxygen delivery: facts and controversies. Antioxid Redox Signal. 2010 Mar 15; 12(6):683-91. PMID: 19757988; PMCID: PMC2834451.
    39. Buehler PW, Zhou Y, Cabrales P, Jia Y, Sun G, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins. Biomaterials. 2010 May; 31(13):3723-35. PMID: 20149433; PMCID: PMC2837140.
    40. Vázquez BY, Hightower CM, Sapuppo F, Tartakovsky DM, Intaglietta M. Functional optical imaging at the microscopic level. J Biomed Opt. 2010 Jan-Feb; 15(1):011102. PMID: 20210428; PMCID: PMC2816989.
    41. Vázquez BY, Vázquez MA, Jáquez MG, Huemoeller AH, Intaglietta M, Cabrales P. Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals. Clin Hemorheol Microcirc. 2010; 44(1):55-61. PMID: 20134093.
      View in: PubMed
    42. Bertuglia S, Intaglietta M. pO(2) and ROS/RNS measurements in the microcirculation in hypoxia. Methods Mol Biol. 2010; 594:19-41. PMID: 20072907.
      View in: PubMed
    43. Hightower CM, Hightower JD, Vázquez BY, Intaglietta M. Seasonal hematocrit variation and health risks in the adult population of Kinshasa, Democratic Republic of Congo. Vasc Health Risk Manag. 2009; 5:1001-5. PMID: 19997569; PMCID: PMC2788592.
    44. Cabrales P, Sun G, Zhou Y, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. J Appl Physiol (1985). 2009 Nov; 107(5):1548-58. PMID: 19745190; PMCID: PMC2777796.
    45. Vázquez BY, Vázquez MA, Intaglietta M, de Faire U, Fagrell B, Cabrales P. Hematocrit and mean arterial blood pressure in pre- and postmenopause women. Vasc Health Risk Manag. 2009; 5(2):483-8. PMID: 19554088; PMCID: PMC2697582.
    46. Meng F, Manjula BN, Tsai AG, Cabrales P, Intaglietta M, Smith PK, Prabhakaran M, Acharya SA. Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts. Protein J. 2009 Jun; 28(5):199-212. PMID: 19653083.
      View in: PubMed
    47. Villela NR, Cabrales P, Tsai AG, Intaglietta M. Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model. Shock. 2009 Jun; 31(6):645-52. PMID: 18948853.
      View in: PubMed
    48. Cabrales P, Tsai AG, Intaglietta M. Exogenous nitric oxide induces protection during hemorrhagic shock. Resuscitation. 2009 Jun; 80(6):707-12. PMID: 19362408; PMCID: PMC2747810.
    49. Villela NR, Salazar Vázquez BY, Vázques BY, Intaglietta M. Microcirculatory effects of intravenous fluids in critical illness: plasma expansion beyond crystalloids and colloids. Curr Opin Anaesthesiol. 2009 Apr; 22(2):163-7. PMID: 19307891.
      View in: PubMed
    50. Cabrales P, Tsai AG, Intaglietta M. Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters. Shock. 2009 Mar; 31(3):300-7. PMID: 18636045.
      View in: PubMed
    51. Intaglietta M. Increased blood viscosity: disease, adaptation or treatment? Clin Hemorheol Microcirc. 2009; 42(4):305-6. PMID: 19628897.
      View in: PubMed
    52. Kim S, Ong PK, Yalcin O, Intaglietta M, Johnson PC. The cell-free layer in microvascular blood flow. Biorheology. 2009; 46(3):181-9. PMID: 19581726.
      View in: PubMed
    53. Cabrales P, Tsai AG, Intaglietta M. Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2212-8. PMID: 18835914; PMCID: PMC2614583.
    54. Cabrales P, Tsai AG, Ananda K, Acharya SA, Intaglietta M. Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. Resuscitation. 2008 Oct; 79(1):139-46. PMID: 18621463; PMCID: PMC2758307.
    55. Cabrales P, Tsai AG, Intaglietta M. Balance between vasoconstriction and enhanced oxygen delivery. Transfusion. 2008 Oct; 48(10):2087-95. PMID: 18631171; PMCID: PMC2747808.
    56. Gardeazábal T, Cabrera M, Cabrales P, Intaglietta M, Briceño JC. Oxygen transport during hemodilution with a perfluorocarbon-based oxygen carrier: effect of altitude and hyperoxia. J Appl Physiol (1985). 2008 Aug; 105(2):588-94. PMID: 18535127.
      View in: PubMed
    57. Hightower CM, Intaglietta M. Early iNOS impairment and late eNOS enhancement during reperfusion following 2.49 MHz continuous ultrasound exposure after ischemia. Ultrason Sonochem. 2009 Jan; 16(1):197-203. PMID: 18595762; PMCID: PMC2579745.
    58. Salazar Vázquez BY, Wettstein R, Cabrales P, Tsai AG, Intaglietta M. Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation. Biochim Biophys Acta. 2008 Oct; 1784(10):1421-7. PMID: 18502215; PMCID: PMC2886513.
    59. Martini J, Cabrales P, K A, Acharya SA, Intaglietta M, Tsai AG. Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective. Crit Care. 2008; 12(2):R54. PMID: 18423033; PMCID: PMC2447609.
    60. Sakai H, Sato A, Sobolewski P, Takeoka S, Frangos JA, Kobayashi K, Intaglietta M, Tsuchida E. NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers. Biochim Biophys Acta. 2008 Oct; 1784(10):1441-7. PMID: 18405675.
      View in: PubMed
    61. Cabrales P, Tsai AG, Intaglietta M. Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock. Resuscitation. 2008 Jun; 77(3):379-86. PMID: 18308459; PMCID: PMC3224810.
    62. Winslow RM, Intaglietta M. Red cell age and loss of function: advance or SNO-job? Transfusion. 2008 Mar; 48(3):411-4. PMID: 18302664.
      View in: PubMed
    63. Cabrales P, Salazar Vázquez MA, Salazar Vázquez B, Rodríguez-Morán M, Intaglietta M, Guerrero-Romeros F. Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients. Vasc Health Risk Manag. 2008; 4(4):917-22. PMID: 19066010; PMCID: PMC2597772.
    64. Salazar Vázquez BY, Salazar Vázquez MA, Venzor VC, Negrete AC, Cabrales P, Díaz JS, Intaglietta M. Increased hematocrit and reduced blood pressure following control of glycemia in diabetes. Clin Hemorheol Microcirc. 2008; 38(1):57-64. PMID: 18094460.
      View in: PubMed
    65. Hightower CM, Intaglietta M. Diagnostic frequency continuous ultrasonography directly mitigates venular ischemia reperfusion damage. J Am Coll Surg. 2008 Mar; 206(3):540-7. PMID: 18308227.
      View in: PubMed
    66. Cabrales P, Tsai AG, Intaglietta M. Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes. Shock. 2007 Oct; 28(4):461-7. PMID: 17558350.
      View in: PubMed
    67. Cabrales P, Tsai AG, Intaglietta M. Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):354-61. PMID: 17884988; PMCID: PMC2258455.
    68. Salazar Vázquez BY, Cabrales P, Tsai AG, Johnson PC, Intaglietta M. Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):135-42. PMID: 17709601; PMCID: PMC2214674.
    69. Hightower CM, Intaglietta M. The use of diagnostic frequency continuous ultrasound to improve microcirculatory function after ischemia-reperfusion injury. Microcirculation. 2007 Aug; 14(6):571-82. PMID: 17710628; PMCID: PMC2597308.
    70. Acharya SA, Acharya VN, Kanika ND, Tsai AG, Intaglietta M, Manjula BN. Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation. Biochem J. 2007 Aug 01; 405(3):503-11. PMID: 17425516; PMCID: PMC2267292.
    71. Kim S, Zhen J, Popel AS, Intaglietta M, Johnson PC. Contributions of collision rate and collision efficiency to erythrocyte aggregation in postcapillary venules at low flow rates. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1947-54. PMID: 17616741.
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    72. Cabrales P, Intaglietta M. Time-dependant oxygen partial pressure in capillaries and tissue in the hamster window chamber model. Antioxid Redox Signal. 2007 Jul; 9(7):845-53. PMID: 17508910.
      View in: PubMed
    73. Tsai AG, Johnson PC, Intaglietta M. Is the distribution of tissue pO(2) homogeneous? Antioxid Redox Signal. 2007 Jul; 9(7):979-84. PMID: 17508919.
      View in: PubMed
    74. Kim S, Kong RL, Popel AS, Intaglietta M, Johnson PC. Temporal and spatial variations of cell-free layer width in arterioles. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1526-35. PMID: 17526647.
      View in: PubMed
    75. Cabrales P, Intaglietta M, Tsai AG. Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation. 2007 Oct; 75(1):124-34. PMID: 17481796; PMCID: PMC3224809.
    76. Tsai AG, Cabrales P, Johnson PC, Intaglietta M. New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions. J Appl Physiol (1985). 2007 May; 102(5):2081-2; author reply 2083. PMID: 17483445.
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    77. Cabrales P, Tsai AG, Intaglietta M. Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity? Shock. 2007 Apr; 27(4):380-9. PMID: 17414420.
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    78. Hangai-Hoger N, Tsai AG, Cabrales P, Suematsu M, Intaglietta M. Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. Crit Care Med. 2007 Apr; 35(4):1123-32. PMID: 17334240.
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    79. Cabrales P, Vázquez BY, Tsai AG, Intaglietta M. Microvascular and capillary perfusion following glycocalyx degradation. J Appl Physiol (1985). 2007 Jun; 102(6):2251-9. PMID: 17347383.
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    80. Cabrales P, Tsai AG, Intaglietta M. Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin. Antioxid Redox Signal. 2007 Mar; 9(3):375-84. PMID: 17184174.
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    81. Tóth A, Pal M, Intaglietta M, Johnson PC. Contribution of anaerobic metabolism to reactive hyperemia in skeletal muscle. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H2643-53. PMID: 17308008.
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    82. Martini J, Gramaglia I, Intaglietta M, van der Heyde HC. Impairment of functional capillary density but not oxygen delivery in the hamster window chamber during severe experimental malaria. Am J Pathol. 2007 Feb; 170(2):505-17. PMID: 17255319; PMCID: PMC1851866.
    83. Frietsch T, Gassmann M, Groth G, Waschke KF, Vogel J, Cabrales P, Vajkoczi P, Dorn-Beineke A, Intaglietta M, Kerger H. Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue. Microcirculation. 2007 Feb; 14(2):111-23. PMID: 17365666.
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    84. Cabrales P, Tsai AG, Intaglietta M. Perfluorocarbon in microcirculation during ischemia reperfusion. J Am Coll Surg. 2007 Feb; 204(2):225-35. PMID: 17254926.
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    85. Hangai-Hoger N, Tsai AG, Cabrales P, Intaglietta M. Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2. Lymphat Res Biol. 2007; 5(3):159-68. PMID: 18035934.
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    86. Gramaglia I, Sobolewski P, Meays D, Contreras R, Nolan JP, Frangos JA, Intaglietta M, van der Heyde HC. Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med. 2006 Dec; 12(12):1417-22. PMID: 17099710.
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    87. Cabrales P, Tsai AG, Intaglietta M. Hemorrhagic shock resuscitation with carbon monoxide saturated blood. Resuscitation. 2007 Feb; 72(2):306-18. PMID: 17092627.
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    88. Wettstein R, Tsai AG, Harder Y, Erni D, Intaglietta M. Early resuscitation with polymerized bovine hemoglobin reverses acidosis, but not peripheral tissue oxygenation, in a severe hamster shock model. Shock. 2006 Nov; 26(5):496-503. PMID: 17047521.
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    89. Tsai AG, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M. Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood. 2006 Nov 15; 108(10):3603-10. PMID: 16857991; PMCID: PMC1895434.
    90. Salazar-Vazquez BY, Intaglietta M, Rodríguez-Morán M, Guerrero-Romero F. Blood pressure and hematocrit in diabetes and the role of endothelial responses in the variability of blood viscosity. Diabetes Care. 2006 Jul; 29(7):1523-8. PMID: 16801573.
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    91. Wettstein R, Erni D, Intaglietta M, Tsai AG. Rapid restoration of microcirculatory blood flow with hyperviscous and hyperoncotic solutions lowers the transfusion trigger in resuscitation from hemorrhagic shock. Shock. 2006 Jun; 25(6):641-6. PMID: 16721273.
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    141. Tsai AG, Johnson PC, Intaglietta M. Oxygen gradients in the microcirculation. Physiol Rev. 2003 Jul; 83(3):933-63. PMID: 12843412.
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    146. Bishop JJ, Popel AS, Intaglietta M, Johnson PC. Effect of aggregation and shear rate on the dispersion of red blood cells flowing in venules. Am J Physiol Heart Circ Physiol. 2002 Nov; 283(5):H1985-96. PMID: 12384477.
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    148. Haidekker MA, Tsai AG, Brady T, Stevens HY, Frangos JA, Theodorakis E, Intaglietta M. A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1609-14. PMID: 11959622.
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    149. Tsai AG, Intaglietta M. The unusual properties of effective blood substitutes. Keio J Med. 2002 Mar; 51(1):17-20. PMID: 11951374.
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    150. Mazzoni MC, Tsai AG, Intaglietta M. Blood and plasma viscosity and microvascular function in hemodilution. A perspective from La Jolla, California. Eur Surg Res. 2002 Jan-Apr; 34(1-2):101-5. PMID: 11867909.
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