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Napoleone Ferrara

Title(s)Professor, Pathology
SchoolHealth Sciences
Address9500 Gilman Drive #0819
La Jolla CA 92093
Phone858-822-6822
Emailnferrara@ucsd.edu
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    Collapse Biography 
    Collapse Education and Training
    University of Catania Medical SchoolM.D.1981Medicine and Surgery
    UCSF, San Francisco, CAPostdoctoral Fellowship1983-85Reproductive Endocrinology
    Oregon Health Sciences University, Portland, ORInternship 1985-86
    UCSF, San Francisco, CAPostdoctoral Fellowship1986-88Cancer Research
    Collapse Awards and Honors
    2020Member of Retina Hall of Fame
    2019G.B. Bietti Gold Medal
    2015Elected to the National Academy of Medicine
    2015Leslie Dana Gold Medal
    2014Gairdner Foundation Int’l Award
    2014A. Champalimaud Vision Award
    2013Breakthrough Prize in Life Sciences
    2013Elected Fellow, AACR Academy
    2012The Economist Innovation Award
    2011Dr. Paul Janssen Award for Biomedical Research
    2010Lasker Award
    2010Macula Society-Michaelson Award
    2009Pezcoller Foundation/AACR International Award
    2008Macula Society-Arnall Patz Award
    2007ASCO Science of Oncology Award
    2006Elected to the National Academy of Sciences
    2006General Motors Cancer Research Award
    2006Passano Award
    2005Lefoulon-Delalande-Institut-de France Prize
    2005AACR Bruce F. Cain Memorial Award
    2004Italian Assoc. Res. Therapy Eye Disorders (AIRCMO) Prize
    2004American-Italian Cancer Foundation Prize

    Collapse Overview 
    Collapse Overview
    Napoleone Ferrara, M.D., is currently Distinguished Professor of Pathology and Adjunct Professor of Ophthalmology and Pharmacology. His main research interests are the biology of angiogenesis and the identification of its regulators. In 1989, while at Genentech, Inc., he reported the isolation and cloning of vascular endothelial growth factor (VEGF) and subsequently focused his research on the investigation of the molecular and biological properties of VEGF. These studies established VEGF as a key regulator of normal and pathological angiogenesis. Together with his colleagues, he reported that VEGF inhibition results in suppression of growth of a variety of tumors in vivo. These findings represented the first direct evidence that inhibition of angiogenesis can block tumor growth and led to the development of a humanized anti-VEGF monoclonal antibody (Bevacizumab) as a cancer therapy. Bevacizumab has been approved by the USA FDA for 11 indications in multiple cancer types. The discovery that VEGF is a key mediator of angiogenesis associated with intraocular neovascular syndromes resulted in the clinical development of a humanized anti-VEGF Fab (Ranibizumab), which has been approved for therapy of neovascular age-related macular degeneration (AMD) and other ocular vascular disorders. Ranibizumab and other anti-VEGF agents represent the first effective therapy for such blinding disorders and rank among the most widely used drugs in older adults.

    Collapse Research 
    Collapse Research Activities and Funding
    Novel Long-Acting Inhibitors of Vascular Endothelial Growth Factor (VEGF) for Treatment of Intraocular Vascular Disorders
    NIH/NEI R01EY031345Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Identification of novel inhibitors of ocular neovascularization
    NIH/NEI R21EY028701Apr 1, 2018 - Mar 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21598-21608. Itatani Y, Yamamoto T, Zhong C, Molinolo AA, Ruppel J, Hegde P, Taketo MM, Ferrara N. PMID: 32817421.
      View in: PubMed   Mentions:    Fields:    
    2. Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas. . 2020 Sep; 19(9):1784-1796. Gilardi M, Wang Z, Proietto M, Chillà A, Calleja-Valera JL, Goto Y, Vanoni M, Janes MR, Mikulski Z, Gualberto A, Molinolo AA, Ferrara N, Gutkind JS, Burrows F. PMID: 32727882.
      View in: PubMed   Mentions:    Fields:    
    3. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019 03 07; 176(6):1248-1264. Apte RS, Chen DS, Ferrara N. PMID: 30849371.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    4. Interleukin-22 promotes tumor angiogenesis. Angiogenesis. 2019 05; 22(2):311-323. Protopsaltis NJ, Liang W, Nudleman E, Ferrara N. PMID: 30539314.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Metastatic growth instructed by neutrophil-derived transferrin. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):11060-11065. Liang W, Li Q, Ferrara N. PMID: 30301793.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    6. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. PMID: 29766399.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    7. Introduction by the Guest Editors: Bevacizumab. Cancer J. 2018 Jul/Aug; 24(4):163-164. Ferrara N, Chen DS. PMID: 30119078.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis. Physiol Rev. 2018 04 01; 98(2):1055-1082. Negri L, Ferrara N. PMID: 29537336.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    9. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. Nat Commun. 2017 11 17; 8(1):1574. Eilken HM, Diéguez-Hurtado R, Schmidt I, Nakayama M, Jeong HW, Arf H, Adams S, Ferrara N, Adams RH. PMID: 29146905.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    10. Microvascular Density as a Predictive Biomarker for Bevacizumab Survival Benefit in Ovarian Cancer: Back to First Principles? J Natl Cancer Inst. 2017 11 01; 109(11). Ferrara N. PMID: 29059427.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Evidence for Pro-angiogenic Functions of VEGF-Ax. Cell. 2016 Sep 22; 167(1):275-284.e6. Xin H, Zhong C, Nudleman E, Ferrara N. PMID: 27662093.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    12. Commentary on "Humanization of an Anti-VEGF Monoclonal Antibody for the Therapy of Solid Tumors and Other Disorders". Cancer Res. 2016 09 01; 76(17):4913-5. Ferrara N. PMID: 27587649.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 Aug 25; 166(5):1338-1340. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. PMID: 27565353.
      View in: PubMed   Mentions: 7     Fields:    
    14. VEGF and Intraocular Neovascularization: From Discovery to Therapy. Transl Vis Sci Technol. 2016 Mar; 5(2):10. Ferrara N. PMID: 26981332.
      View in: PubMed   Mentions:
    15. Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model. Neuro Oncol. 2016 07; 18(7):939-49. Osterberg N, Ferrara N, Vacher J, Gaedicke S, Niedermann G, Weyerbrock A, Doostkam S, Schaefer HE, Plate KH, Machein MR. PMID: 26951383.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Outer retinal tubulations response to anti-VEGF treatment. Br J Ophthalmol. 2016 06; 100(6):819-23. Espina M, Arcinue CA, Ma F, Camacho N, Barteselli G, Mendoza N, Ferrara N, Freeman WR. PMID: 26423451.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer Cell. 2015 Jun 08; 27(6):780-96. Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R. PMID: 26058077.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    18. Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice. PLoS One. 2015; 10(2):e0116332. Sargent KM, Lu N, Clopton DT, Pohlmeier WE, Brauer VM, Ferrara N, Silversides DW, Cupp AS. PMID: 25658474.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    19. Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development. 2015 Feb 15; 142(4):672-80. Eshkar-Oren I, Krief S, Ferrara N, Elliott AM, Zelzer E. PMID: 25617432.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    20. Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A. Mol Pharm. 2014 Oct 06; 11(10):3421-30. Yang J, Wang X, Fuh G, Yu L, Wakshull E, Khosraviani M, Day ES, Demeule B, Liu J, Shire SJ, Ferrara N, Yadav S. PMID: 25162961.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    21. A conversation with Napoleone Ferrara. J Clin Invest. 2014 Aug; 124(8):3275-6. Ferrara N, Neill US. PMID: 25083827.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014 Jul 04; 3(8):679-88. Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E. PMID: 24996922.
      View in: PubMed   Mentions:
    23. VEGF modulates synaptic activity in the developing spinal cord. Dev Neurobiol. 2014 Nov; 74(11):1110-22. Guérit S, Allain AE, Léon C, Cazenave W, Ferrara N, Branchereau P, Bikfalvi A. PMID: 24782305.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. Inhibiting the response to VEGF in diabetes. Sci Signal. 2014 Jan 07; 7(307):pe1. Moriya J, Ferrara N. PMID: 24399294.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    25. A message from the new editor-in-chief. . 2014 Jan; 13(1):3-4. Ferrara N. PMID: 24385543.
      View in: PubMed   Mentions:
    26. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development. 2014 Jan; 141(2):448-59. Fan J, Ponferrada VG, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang RA. PMID: 24353059.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    27. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat Med. 2013 Sep; 19(9):1114-23. Chung AS, Wu X, Zhuang G, Ngu H, Kasman I, Zhang J, Vernes JM, Jiang Z, Meng YG, Peale FV, Ouyang W, Ferrara N. PMID: 23913124.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    28. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013 Sep; 5(9):1415-30. Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. PMID: 23853117.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    29. Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice. J Vasc Surg. 2014 May; 59(5):1402-9.e1-4. Moriya J, Wu X, Zavala-Solorio J, Ross J, Liang XH, Ferrara N. PMID: 23856609.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Neoplasia. 2013 Jul; 15(7):694-711. Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA. PMID: 23814482.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    31. Development and preclinical characterization of a humanized antibody targeting CXCL12. Clin Cancer Res. 2013 Aug 15; 19(16):4433-45. Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N. PMID: 23812669.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife. 2013 Jun 18; 2:e00324. Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK. PMID: 23795287.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    33. Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies. Clin Cancer Res. 2013 Jul 01; 19(13):3681-92. Brauer MJ, Zhuang G, Schmidt M, Yao J, Wu X, Kaminker JS, Jurinka SS, Kolumam G, Chung AS, Jubb A, Modrusan Z, Ozawa T, James CD, Phillips H, Haley B, Tam RN, Clermont AC, Cheng JH, Yang SX, Swain SM, Chen D, Scherer SJ, Koeppen H, Yeh RF, Yue P, Stephan JP, Hegde P, Ferrara N, Singh M, Bais C. PMID: 23685835.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    34. Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases. Sci Signal. 2013 Apr 16; 6(271):ra25. Zhuang G, Yu K, Jiang Z, Chung A, Yao J, Ha C, Toy K, Soriano R, Haley B, Blackwood E, Sampath D, Bais C, Lill JR, Ferrara N. PMID: 23592840.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    35. Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6079-84. Phan VT, Wu X, Cheng JH, Sheng RX, Chung AS, Zhuang G, Tran C, Song Q, Kowanetz M, Sambrone A, Tan M, Meng YG, Jackson EL, Peale FV, Junttila MR, Ferrara N. PMID: 23530240.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    36. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. PMID: 23452854.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    37. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013 Feb 14; 494(7436):243-6. Rao S, Chun C, Fan J, Kofron JM, Yang MB, Hegde RS, Ferrara N, Copenhagen DR, Lang RA. PMID: 23334418.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    38. Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood. 2013 Mar 28; 121(13):2574-8. Stefater JA, Rao S, Bezold K, Aplin AC, Nicosia RF, Pollard JW, Ferrara N, Lang RA. PMID: 23303818.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell. 2012 Oct 12; 151(2):384-99. Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, Jeansson M, Zhang C, Tucholska M, Jones N, Kerjaschki D, Shibuya M, Fantus IG, Nagy A, Gerber HP, Ferrara N, Pawson T, Quaggin SE. PMID: 23063127.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    40. Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology. 2013 Jan; 120(1):106-14. Miller JW, Le Couter J, Strauss EC, Ferrara N. PMID: 23031671.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    41. S1P1 inhibits sprouting angiogenesis during vascular development. Development. 2012 Oct; 139(20):3859-69. Ben Shoham A, Malkinson G, Krief S, Shwartz Y, Ely Y, Ferrara N, Yaniv K, Zelzer E. PMID: 22951644.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    42. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 2012 Sep; 122(9):3101-13. Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR. PMID: 22886301.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    43. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat Biotechnol. 2012 Jul 10; 30(7):648-57. Singh M, Ferrara N. PMID: 22781694.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    44. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012 Aug 29; 31(17):3513-23. Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Guan Y, Oeh J, Modrusan Z, Bais C, Sampath D, Ferrara N. PMID: 22773185.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    45. Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J Pathol. 2012 Aug; 227(4):404-16. Chung AS, Kowanetz M, Wu X, Zhuang G, Ngu H, Finkle D, Komuves L, Peale F, Ferrara N. PMID: 22611017.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    46. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J Pathol. 2012 Aug; 227(4):417-30. Singh M, Couto SS, Forrest WF, Lima A, Cheng JH, Molina R, Long JE, Hamilton P, McNutt A, Kasman I, Nannini MA, Reslan HB, Cao TC, Ho CC, Barck KH, Carano RA, Foreman O, Eastham-Anderson J, Jubb AM, Ferrara N, Johnson L. PMID: 22611036.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    47. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012 Jul; 122(7):2454-68. Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. PMID: 22653056.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    48. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood. 2012 Jul 19; 120(3):613-25. Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA. PMID: 22577176.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    49. Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. J Biol Chem. 2012 Jun 01; 287(23):19574-84. Qu X, Zhuang G, Yu L, Meng G, Ferrara N. PMID: 22528488.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    50. Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11590-5. Yao J, Wu X, Zhuang G, Kasman IM, Vogt T, Phan V, Shibuya M, Ferrara N, Bais C. PMID: 21709213.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    51. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 2011 May 29; 474(7352):511-5. Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, Lang RA. PMID: 21623369.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    52. Multiple effects of angiopoietin-2 blockade on tumors. Cancer Cell. 2011 Apr 12; 19(4):431-3. Lewis CE, Ferrara N. PMID: 21481783.
      View in: PubMed   Mentions: 10     Fields:    
    53. Comparing protein VEGF inhibitors: In vitro biological studies. Biochem Biophys Res Commun. 2011 May 06; 408(2):276-81. Yu L, Liang XH, Ferrara N. PMID: 21501594.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    54. From the discovery of vascular endothelial growth factor to the introduction of avastin in clinical trials - an interview with Napoleone Ferrara by Domenico Ribatti. Int J Dev Biol. 2011; 55(4-5):383-8. Ferrara N. PMID: 21858763.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    55. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21248-55. Kowanetz M, Wu X, Lee J, Tan M, Hagenbeek T, Qu X, Yu L, Ross J, Korsisaari N, Cao T, Bou-Reslan H, Kallop D, Weimer R, Ludlam MJ, Kaminker JS, Modrusan Z, van Bruggen N, Peale FV, Carano R, Meng YG, Ferrara N. PMID: 21081700.
      View in: PubMed   Mentions: 182     Fields:    Translation:AnimalsCells
    56. Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat Med. 2010 Oct; 16(10):1107-11. Ferrara N. PMID: 20930754.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    57. Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature. PLoS One. 2010 Jul 29; 5(7):e11863. Scott A, Powner MB, Gandhi P, Clarkin C, Gutmann DH, Johnson RS, Ferrara N, Fruttiger M. PMID: 20686684.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    58. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer. 2010 07; 10(7):505-14. Chung AS, Lee J, Ferrara N. PMID: 20574450.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansAnimals
    59. Vegf regulates embryonic erythroid development through Gata1 modulation. Blood. 2010 Sep 23; 116(12):2141-51. Drogat B, Kalucka J, Gutiérrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmüller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ. PMID: 20554972.
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    138. Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood. 2004 Jul 01; 104(1):149-58. Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP. PMID: 15016650.
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    139. EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors. Biochim Biophys Acta. 2004 Mar 04; 1654(1):69-78. Ferrara N, LeCouter J, Lin R, Peale F. PMID: 14984768.
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    140. Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor. Thromb Haemost. 2004 Mar; 91(3):595-605. Raab S, Beck H, Gaumann A, Yüce A, Gerber HP, Plate K, Hammes HP, Ferrara N, Breier G. PMID: 14983237.
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    141. Neutralizing VEGF bioactivity with a soluble chimeric VEGF-receptor protein flt(1-3)IgG inhibits testosterone-stimulated prostate growth in castrated mice. Prostate. 2004 Jan 01; 58(1):57-65. Lissbrant IF, Hammarsten P, Lissbrant E, Ferrara N, Rudolfsson SH, Bergh A. PMID: 14673953.
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    142. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist. 2004; 9 Suppl 1:2-10. Ferrara N. PMID: 15178810.
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    143. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol. 2003 Oct 15; 262(2):225-41. Haigh JJ, Morelli PI, Gerhardt H, Haigh K, Tsien J, Damert A, Miquerol L, Muhlner U, Klein R, Ferrara N, Wagner EF, Betsholtz C, Nagy A. PMID: 14550787.
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    144. EG-VEGF and Bv8. a novel family of tissue-selective mediators of angiogenesis, endothelial phenotype, and function. Trends Cardiovasc Med. 2003 Oct; 13(7):276-82. LeCouter J, Ferrara N. PMID: 14522467.
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    145. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 2003 Aug; 4(2):133-46. Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, Bergers G. PMID: 12957288.
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    146. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol. 2003 Jun 17; 13(12):1070-4. Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA. PMID: 12814555.
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    147. Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis. Endocrinology. 2003 Jun; 144(6):2606-16. LeCouter J, Lin R, Frantz G, Zhang Z, Hillan K, Ferrara N. PMID: 12746324.
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    148. The biology of VEGF and its receptors. Nat Med. 2003 Jun; 9(6):669-76. Ferrara N, Gerber HP, LeCouter J. PMID: 12778165.
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    149. Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries. Am J Pathol. 2003 Jun; 162(6):1881-93. Ferrara N, Frantz G, LeCouter J, Dillard-Telm L, Pham T, Draksharapu A, Giordano T, Peale F. PMID: 12759245.
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    150. Diabetic patients and retinal proliferation: an evaluation of the role of vascular endothelial growth factor (VEGF). Exp Clin Endocrinol Diabetes. 2003 Jun; 111(4):209-14. Nicoletti VG, Nicoletti R, Ferrara N, Meli G, Reibaldi M, Reibaldi A. PMID: 12845559.
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    151. Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Exp Cell Res. 2003 May 01; 285(2):286-98. Tille JC, Wang X, Lipson KE, McMahon G, Ferrara N, Zhu Z, Hicklin DJ, Sleeman JP, Eriksson U, Alitalo K, Pepper MS. PMID: 12706123.
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    152. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003 Mar 07; 112(5):645-57. Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. PMID: 12628185.
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    153. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 2003 Mar; 111(5):707-16. Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber HP, Kikkawa Y, Miner JH, Quaggin SE. PMID: 12618525.
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    154. The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2685-90. LeCouter J, Lin R, Tejada M, Frantz G, Peale F, Hillan KJ, Ferrara N. PMID: 12604792.
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    155. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science. 2003 Feb 07; 299(5608):890-3. LeCouter J, Moritz DR, Li B, Phillips GL, Liang XH, Gerber HP, Hillan KJ, Ferrara N. PMID: 12574630.
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    156. The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med (Berl). 2003 Jan; 81(1):20-31. Gerber HP, Ferrara N. PMID: 12545246.
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    157. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol. 2002 Dec; 29(6 Suppl 16):10-4. Ferrara N. PMID: 12516033.
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    158. Vascular endothelial growth factor immunoneutralization plus Paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer. Am J Pathol. 2002 Nov; 161(5):1917-24. Hu L, Hofmann J, Zaloudek C, Ferrara N, Hamilton T, Jaffe RB. PMID: 12414537.
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    159. Endocrine gland vascular endothelial growth factor (EG-VEGF) and the hypothesis of tissue-specific regulation of angiogenesis. Endocr Res. 2002 Nov; 28(4):763-4. Ferrara N, LeCouter J, Lin R. PMID: 12530695.
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    160. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer. 2002 Oct; 2(10):795-803. Ferrara N. PMID: 12360282.
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    162. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9656-61. Street J, Bao M, deGuzman L, Bunting S, Peale FV, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, van Bruggen N, Redmond HP, Carano RA, Filvaroff EH. PMID: 12118119.
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    163. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature. 2002 Jun 27; 417(6892):954-8. Gerber HP, Malik AK, Solar GP, Sherman D, Liang XH, Meng G, Hong K, Marsters JC, Ferrara N. PMID: 12087404.
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    164. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. J Biol Chem. 2002 May 10; 277(19):17281-90. Camenisch G, Pisabarro MT, Sherman D, Kowalski J, Nagel M, Hass P, Xie MH, Gurney A, Bodary S, Liang XH, Clark K, Beresini M, Ferrara N, Gerber HP. PMID: 11877390.
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    166. VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. . 2002 Jan; 282(1):R199-206. Clyman RI, Seidner SR, Kajino H, Roman C, Koch CJ, Ferrara N, Waleh N, Mauray F, Chen YQ, Perkett EA, Quinn T. PMID: 11742839.
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    169. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J Virol. 2001 Oct; 75(20):9828-35. Zheng M, Deshpande S, Lee S, Ferrara N, Rouse BT. PMID: 11559816.
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    170. Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice. J Magn Reson Imaging. 2001 Oct; 14(4):374-82. Williams SP, Gerber HP, Giordano FJ, Peale FV, Bernstein LJ, Bunting S, Chien KR, Ferrara N, van Bruggen N. PMID: 11599061.
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    171. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature. 2001 Aug 30; 412(6850):877-84. LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, Dillard-Telm L, Frantz G, Rangell L, DeGuzman L, Keller GA, Peale F, Gurney A, Hillan KJ, Ferrara N. PMID: 11528470.
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    174. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5780-5. Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. PMID: 11331753.
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    175. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol. 2001 Mar; 158(3):1111-20. Xin X, Yang S, Ingle G, Zlot C, Rangell L, Kowalski J, Schwall R, Ferrara N, Gerritsen ME. PMID: 11238059.
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    176. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol. 2001; 106(4):148-56. Ferrara N, Gerber HP. PMID: 11815711.
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    178. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res. 2000 Nov 15; 60(22):6253-8. Gerber HP, Kowalski J, Sherman D, Eberhard DA, Ferrara N. PMID: 11103779.
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    179. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J Biol Chem. 2001 Feb 02; 276(5):3222-30. Gille H, Kowalski J, Li B, LeCouter J, Moffat B, Zioncheck TF, Pelletier N, Ferrara N. PMID: 11058584.
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    180. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000 Oct 01; 60(19):5565-70. Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y. PMID: 11034104.
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    182. VEGF regulates cell behavior during vasculogenesis. Dev Biol. 2000 Aug 15; 224(2):178-88. Drake CJ, LaRue A, Ferrara N, Little CD. PMID: 10926758.
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    183. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration. EMBO J. 2000 Aug 01; 19(15):4064-73. Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N. PMID: 10921887.
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    184. Angiogenesis and bone growth. Trends Cardiovasc Med. 2000 Jul; 10(5):223-8. Gerber HP, Ferrara N. PMID: 11282299.
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    185. Formation of endothelial cell networks. Nature. 2000 May 11; 405(6783):139-41. Helmlinger G, Endo M, Ferrara N, Hlatky L, Jain RK. PMID: 10821260.
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    186. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development. 2000 Apr; 127(7):1445-53. Haigh JJ, Gerber HP, Ferrara N, Wagner EF. PMID: 10704390.
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    189. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest. 1999 Dec; 104(11):1613-20. van Bruggen N, Thibodeaux H, Palmer JT, Lee WP, Fu L, Cairns B, Tumas D, Gerlai R, Williams SP, van Lookeren Campagne M, Ferrara N. PMID: 10587525.
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    190. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol Pathol. 1999 Sep-Oct; 27(5):536-44. Mordenti J, Cuthbertson RA, Ferrara N, Thomsen K, Berleau L, Licko V, Allen PC, Valverde CR, Meng YG, Fei DT, Fourre KM, Ryan AM. PMID: 10528633.
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    191. Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res. 1999 Sep-Oct; 19(5B):4203-14. Borgström P, Gold DP, Hillan KJ, Ferrara N. PMID: 10628376.
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    192. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int. 1999 Sep; 56(3):794-814. Ferrara N. PMID: 10469350.
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    194. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999 Jun; 5(6):623-8. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. PMID: 10371499.
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    198. Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans. Toxicol Pathol. 1999 Jan-Feb; 27(1):14-21. Mordenti J, Thomsen K, Licko V, Chen H, Meng YG, Ferrara N. PMID: 10367667.
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    202. Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells. J Biol Chem. 1998 Aug 21; 273(34):22128-35. Giraudo E, Primo L, Audero E, Gerber HP, Koolwijk P, Soker S, Klagsbrun M, Ferrara N, Bussolino F. PMID: 9705358.
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