Napoleone Ferrara

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailnferrara@ucsd.edu
ORCID ORCID Icon0000-0002-7029-6375 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Catania Medical SchoolM.D.1981Medicine and Surgery
    UCSF, San Francisco, CAPostdoctoral Fellowship1983-85Reproductive Endocrinology
    Oregon Health Sciences University, Portland, ORInternship 1985-86
    UCSF, San Francisco, CAPostdoctoral Fellowship1986-88Cancer Research
    Collapse Awards and Honors
    2023Prince Mahidol Award in Medicine
    2023Keio Medical Sciences Prize
    2023Duane Roth Achievement Award
    2022Weinman Award in Cancer Research
    2019G.B. Bietti Medal
    2015Elected to the National Academy of Medicine
    2015Leslie Dana Gold Medal
    2014Canada Gairdner International Award
    2014A. Champalimaud Vision Award
    2013Breakthrough Prize in Life Sciences
    2013Elected Fellow, AACR Academy
    2012The Economist Innovation Award
    2011Dr. Paul Janssen Award for Biomedical Research
    2010Lasker-DeBakey Clinical Medical Research Award
    2010Macula Society-Michaelson Award
    2009Pezcoller Foundation/AACR International Award
    2008Macula Society-Arnall Patz Award
    2007ASCO Science of Oncology Award
    2006Elected to the National Academy of Sciences
    2006General Motors Cancer Research Award
    2006Passano Award
    2005AACR Bruce F. Cain Memorial Award
    2005Lefoulon-Delalande-Institut-de France Prize
    2004Italian Assoc. Res. Therapy Eye Disorders (AIRCMO) Prize
    2004American-Italian Cancer Foundation Prize

    Collapse Overview 
    Collapse Overview
    Napoleone Ferrara, M.D., is currently Distinguished Professor of Pathology and Adjunct Professor of Ophthalmology and Pharmacology. He is also the Hildyard Endowed Chair in Eye Disease. His main research interests are the biology of angiogenesis and the identification of its regulators. In 1989 he reported the isolation and cloning of vascular endothelial growth factor (VEGF) and subsequently focused his research on the investigation of the molecular and biological properties of VEGF. These studies established VEGF as a key regulator of normal and pathological angiogenesis. Ferrara and colleagues reported that VEGF inhibition results in suppression of growth of a variety of tumors in vivo. These findings represented the first direct evidence that inhibition of angiogenesis can block tumor growth and led to the development of a humanized anti-VEGF monoclonal antibody (Bevacizumab) as a cancer therapy. Bevacizumab has been approved by the USA FDA for 12 indications in multiple cancer types. The discovery that VEGF is a key mediator of angiogenesis associated with intraocular neovascular syndromes resulted in the clinical development of a humanized anti-VEGF Fab (Ranibizumab), which has been approved for therapy of neovascular age-related macular degeneration (AMD) and other ocular vascular disorders. Ranibizumab and other anti-VEGF agents represent the first effective therapy for such blinding disorders and rank among the most widely used drugs in older adults.

    Collapse Research 
    Collapse Research Activities and Funding
    Novel Long-Acting Inhibitors of Vascular Endothelial Growth Factor (VEGF) for Treatment of Intraocular Vascular Disorders
    NIH R01EY031345Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Identification of novel inhibitors of ocular neovascularization
    NIH R21EY028701Apr 1, 2018 - Mar 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular Basis of Angiogenesis and its Application. Keio J Med. 2024; 73(1):12. Ferrara N. PMID: 38522916.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Development of a Semi-automated Computer-based Tool for the Quantification of Vascular Tortuosity in the Murine Retina. Ophthalmol Sci. 2024 May-Jun; 4(3):100439. Marra KV, Chen JS, Robles-Holmes HK, Miller J, Wei G, Aguilar E, Ideguchi Y, Ly KB, Prenner S, Erdogmus D, Ferrara N, Campbell JP, Friedlander M, Nudleman E. PMID: 38361912; PMCID: PMC10867761.
      View in: PubMed   Mentions:
    3. Therapeutic Potential of Targeting Prokineticin Receptors in Diseases. Pharmacol Rev. 2023 Nov; 75(6):1167-1199. Vincenzi M, Kremic A, Jouve A, Lattanzi R, Miele R, Benharouga M, Alfaidy N, Migrenne-Li S, Kanthasamy AG, Porcionatto M, Ferrara N, Tetko IV, Désaubry L, Nebigil CG. PMID: 37684054; PMCID: PMC10595023.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Biology and therapeutic targeting of vascular endothelial growth factor A. Nat Rev Mol Cell Biol. 2023 Nov; 24(11):816-834. Pérez-Gutiérrez L, Ferrara N. PMID: 37491579.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    5. Applications of Deep Learning: Automated Assessment of Vascular Tortuosity in Mouse Models of Oxygen-Induced Retinopathy. Ophthalmol Sci. 2024 Jan-Feb; 4(1):100338. Chen JS, Marra KV, Robles-Holmes HK, Ly KB, Miller J, Wei G, Aguilar E, Bucher F, Ideguchi Y, Coyner AS, Ferrara N, Campbell JP, Friedlander M, Nudleman E. PMID: 37869029; PMCID: PMC10585474.
      View in: PubMed   Mentions: 1  
    6. Targeting angiogenesis in oncology, ophthalmology and beyond. Nat Rev Drug Discov. 2023 06; 22(6):476-495. Cao Y, Langer R, Ferrara N. PMID: 37041221.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    7. Differential regulation of TNFα and IL-6 expression contributes to immune evasion in prostate cancer. J Transl Med. 2022 11 12; 20(1):527. Deichaite I, Sears TJ, Sutton L, Rebibo D, Morgan K, Nelson T, Rose B, Tamayo P, Ferrara N, Asimakopoulos F, Carter H. PMID: 36371231; PMCID: PMC9652804.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Endothelial cell diversity: the many facets of the crystal. FEBS J. 2022 Oct 20. Perez-Gutierrez L, Li P, Ferrara N. PMID: 36266750.
      View in: PubMed   Mentions: 4     Fields:    
    9. Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cells. Sci Rep. 2022 04 06; 12(1):5807. Domanskyi S, Hakansson A, Meng M, Pham BK, Graff Zivin JS, Piermarocchi C, Paternostro G, Ferrara N. PMID: 35388065; PMCID: PMC8987085.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Vascular heterogeneity: VEGF receptors make blood vessels special. J Exp Med. 2022 03 07; 219(3). Li P, Ferrara N. PMID: 35085381; PMCID: PMC8932539.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    11. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy. EMBO Mol Med. 2022 01 11; 14(1):e14511. Li P, Li Q, Biswas N, Xin H, Diemer T, Liu L, Perez Gutierrez L, Paternostro G, Piermarocchi C, Domanskyi S, Wang RK, Ferrara N. PMID: 34779136; PMCID: PMC8749470.
      View in: PubMed   Mentions: 7     Fields:    
    12. Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Xin H, Biswas N, Li P, Zhong C, Chan TC, Nudleman E, Ferrara N. PMID: 34006633; PMCID: PMC8166142.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Iron Metabolism in the Tumor Microenvironment: Contributions of Innate Immune Cells. Front Immunol. 2020; 11:626812. Liang W, Ferrara N. PMID: 33679721; PMCID: PMC7928394.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    14. Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways. Nat Commun. 2020 12 10; 11(1):6330. Zhong C, Li P, Argade S, Liu L, Chilla' A, Liang W, Xin H, Eliceiri B, Choudhury B, Ferrara N. PMID: 33303737; PMCID: PMC7730427.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer. Proc Natl Acad Sci U S A. 2020 09 01; 117(35):21598-21608. Itatani Y, Yamamoto T, Zhong C, Molinolo AA, Ruppel J, Hegde P, Taketo MM, Ferrara N. PMID: 32817421; PMCID: PMC7474657.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    16. Tipifarnib as a Precision Therapy for HRAS-Mutant Head and Neck Squamous Cell Carcinomas. Mol Cancer Ther. 2020 09; 19(9):1784-1796. Gilardi M, Wang Z, Proietto M, Chillà A, Calleja-Valera JL, Goto Y, Vanoni M, Janes MR, Mikulski Z, Gualberto A, Molinolo AA, Ferrara N, Gutkind JS, Burrows F. PMID: 32727882; PMCID: PMC7484242.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    17. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019 03 07; 176(6):1248-1264. Apte RS, Chen DS, Ferrara N. PMID: 30849371; PMCID: PMC6410740.
      View in: PubMed   Mentions: 834     Fields:    Translation:HumansAnimalsCells
    18. Interleukin-22 promotes tumor angiogenesis. Angiogenesis. 2019 05; 22(2):311-323. Protopsaltis NJ, Liang W, Nudleman E, Ferrara N. PMID: 30539314.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. Metastatic growth instructed by neutrophil-derived transferrin. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):11060-11065. Liang W, Li Q, Ferrara N. PMID: 30301793; PMCID: PMC6205468.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    20. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. PMID: 29766399; PMCID: PMC6237663.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansAnimals
    21. Introduction by the Guest Editors: Bevacizumab. Cancer J. 2018 Jul/Aug; 24(4):163-164. Ferrara N, Chen DS. PMID: 30119078.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    22. The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis. Physiol Rev. 2018 04 01; 98(2):1055-1082. Negri L, Ferrara N. PMID: 29537336.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    23. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. Nat Commun. 2017 11 17; 8(1):1574. Eilken HM, Diéguez-Hurtado R, Schmidt I, Nakayama M, Jeong HW, Arf H, Adams S, Ferrara N, Adams RH. PMID: 29146905; PMCID: PMC5691060.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    24. Microvascular Density as a Predictive Biomarker for Bevacizumab Survival Benefit in Ovarian Cancer: Back to First Principles? J Natl Cancer Inst. 2017 11 01; 109(11). Ferrara N. PMID: 29059427.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol. 2017 Aug; 19(8):915-927. Pitulescu ME, Schmidt I, Giaimo BD, Antoine T, Berkenfeld F, Ferrante F, Park H, Ehling M, Biljes D, Rocha SF, Langen UH, Stehling M, Nagasawa T, Ferrara N, Borggrefe T, Adams RH. PMID: 28714968.
      View in: PubMed   Mentions: 177     Fields:    Translation:AnimalsCells
    26. Evidence for Pro-angiogenic Functions of VEGF-Ax. Cell. 2016 Sep 22; 167(1):275-284.e6. Xin H, Zhong C, Nudleman E, Ferrara N. PMID: 27662093.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    27. Commentary on "Humanization of an Anti-VEGF Monoclonal Antibody for the Therapy of Solid Tumors and Other Disorders". Cancer Res. 2016 09 01; 76(17):4913-5. Ferrara N. PMID: 27587649.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 Aug 25; 166(5):1338-1340. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. PMID: 27565353.
      View in: PubMed   Mentions: 20     Fields:    
    29. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 May 05; 165(4):882-95. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. PMID: 27133169.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    30. VEGF and Intraocular Neovascularization: From Discovery to Therapy. Transl Vis Sci Technol. 2016 Mar; 5(2):10. Ferrara N. PMID: 26981332; PMCID: PMC4790412.
      View in: PubMed   Mentions: 43     Fields:    
    31. Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model. Neuro Oncol. 2016 07; 18(7):939-49. Osterberg N, Ferrara N, Vacher J, Gaedicke S, Niedermann G, Weyerbrock A, Doostkam S, Schaefer HE, Plate KH, Machein MR. PMID: 26951383; PMCID: PMC4896547.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    32. The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis. Cancer Immunol Res. 2016 Feb; 4(2):83-91. Liang W, Ferrara N. PMID: 26839309.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    33. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016 06; 15(6):385-403. Ferrara N, Adamis AP. PMID: 26775688.
      View in: PubMed   Mentions: 381     Fields:    Translation:Humans
    34. Outer retinal tubulations response to anti-VEGF treatment. Br J Ophthalmol. 2016 06; 100(6):819-23. Espina M, Arcinue CA, Ma F, Camacho N, Barteselli G, Mendoza N, Ferrara N, Freeman WR. PMID: 26423451.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    35. A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer Cell. 2015 Jun 08; 27(6):780-96. Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R. PMID: 26058077; PMCID: PMC4469373.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    36. Inhibition of protein kinase C enhances angiogenesis induced by platelet-derived growth factor C in hyperglycemic endothelial cells. Cardiovasc Diabetol. 2015 Feb 07; 14:19. Moriya J, Ferrara N. PMID: 25849290; PMCID: PMC4334399.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice. PLoS One. 2015; 10(2):e0116332. Sargent KM, Lu N, Clopton DT, Pohlmeier WE, Brauer VM, Ferrara N, Silversides DW, Cupp AS. PMID: 25658474; PMCID: PMC4320103.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development. 2015 Feb 15; 142(4):672-80. Eshkar-Oren I, Krief S, Ferrara N, Elliott AM, Zelzer E. PMID: 25617432.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    39. Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A. Mol Pharm. 2014 Oct 06; 11(10):3421-30. Yang J, Wang X, Fuh G, Yu L, Wakshull E, Khosraviani M, Day ES, Demeule B, Liu J, Shire SJ, Ferrara N, Yadav S. PMID: 25162961.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    40. A conversation with Napoleone Ferrara. J Clin Invest. 2014 Aug; 124(8):3275-6. Ferrara N, Neill US. PMID: 25083827; PMCID: PMC4109558.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014 Jul 04; 3(8):679-88. Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E. PMID: 24996922; PMCID: PMC4133721.
      View in: PubMed   Mentions: 12     Fields:    
    42. VEGF modulates synaptic activity in the developing spinal cord. Dev Neurobiol. 2014 Nov; 74(11):1110-22. Guérit S, Allain AE, Léon C, Cazenave W, Ferrara N, Branchereau P, Bikfalvi A. PMID: 24782305.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    43. Inhibiting the response to VEGF in diabetes. Sci Signal. 2014 Jan 07; 7(307):pe1. Moriya J, Ferrara N. PMID: 24399294.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    44. A message from the new editor-in-chief. Mol Cancer Ther. 2014 Jan; 13(1):3-4. Ferrara N. PMID: 24385543.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development. 2014 Jan; 141(2):448-59. Fan J, Ponferrada VG, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang RA. PMID: 24353059; PMCID: PMC3879820.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    46. Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia. Endocrinology. 2013 Dec; 154(12):4790-802. Lu N, Sargent KM, Clopton DT, Pohlmeier WE, Brauer VM, McFee RM, Weber JS, Ferrara N, Silversides DW, Cupp AS. PMID: 24169552; PMCID: PMC3836063.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    47. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat Med. 2013 Sep; 19(9):1114-23. Chung AS, Wu X, Zhuang G, Ngu H, Kasman I, Zhang J, Vernes JM, Jiang Z, Meng YG, Peale FV, Ouyang W, Ferrara N. PMID: 23913124.
      View in: PubMed   Mentions: 226     Fields:    Translation:HumansAnimalsCells
    48. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013 Sep; 5(9):1415-30. Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. PMID: 23853117; PMCID: PMC3799495.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    49. Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice. J Vasc Surg. 2014 May; 59(5):1402-9.e1-4. Moriya J, Wu X, Zavala-Solorio J, Ross J, Liang XH, Ferrara N. PMID: 23856609.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    50. Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Neoplasia. 2013 Jul; 15(7):694-711. Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA. PMID: 23814482; PMCID: PMC3689233.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    51. Development and preclinical characterization of a humanized antibody targeting CXCL12. Clin Cancer Res. 2013 Aug 15; 19(16):4433-45. Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N. PMID: 23812669.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    52. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife. 2013 Jun 18; 2:e00324. Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK. PMID: 23795287; PMCID: PMC3687373.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    53. Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies. Clin Cancer Res. 2013 Jul 01; 19(13):3681-92. Brauer MJ, Zhuang G, Schmidt M, Yao J, Wu X, Kaminker JS, Jurinka SS, Kolumam G, Chung AS, Jubb A, Modrusan Z, Ozawa T, James CD, Phillips H, Haley B, Tam RN, Clermont AC, Cheng JH, Yang SX, Swain SM, Chen D, Scherer SJ, Koeppen H, Yeh RF, Yue P, Stephan JP, Hegde P, Ferrara N, Singh M, Bais C. PMID: 23685835.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    54. Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases. Sci Signal. 2013 Apr 16; 6(271):ra25. Zhuang G, Yu K, Jiang Z, Chung A, Yao J, Ha C, Toy K, Soriano R, Haley B, Blackwood E, Sampath D, Bais C, Lill JR, Ferrara N. PMID: 23592840.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    55. Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6079-84. Phan VT, Wu X, Cheng JH, Sheng RX, Chung AS, Zhuang G, Tran C, Song Q, Kowanetz M, Sambrone A, Tan M, Meng YG, Jackson EL, Peale FV, Junttila MR, Ferrara N. PMID: 23530240; PMCID: PMC3625253.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    56. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. PMID: 23452854; PMCID: PMC3587980.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
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    133. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006 Oct; 26(8):859-70. Ferrara N, Damico L, Shams N, Lowman H, Kim R. PMID: 17031284.
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    136. The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Dev Cell. 2006 Mar; 10(3):397-405. Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fässler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E. PMID: 16516842.
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    138. Angiogenesis as a therapeutic target. Nature. 2005 Dec 15; 438(7070):967-74. Ferrara N, Kerbel RS. PMID: 16355214.
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    142. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol. 2005 Nov; 167(5):1451-9. Marneros AG, Fan J, Yokoyama Y, Gerber HP, Ferrara N, Crouch RK, Olsen BR. PMID: 16251428; PMCID: PMC1603772.
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    144. Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy. Biochem Biophys Res Commun. 2005 Jul 29; 333(2):328-35. Ferrara N, Hillan KJ, Novotny W. PMID: 15961063.
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    145. Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Mech Dev. 2005 Jul; 122(7-8):877-86. Zhao L, Wang K, Ferrara N, Vu TH. PMID: 15927453.
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    146. Napoleone Ferrara discusses Avastin and the future of anti-angiogenesis therapy. Interview by Ulrike Knies-Bamforth and Christopher Watson. Drug Discov Today. 2005 Apr 15; 10(8):539-41. Ferrara N. PMID: 15837595.
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    150. Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16813-8. LeCouter J, Zlot C, Tejada M, Peale F, Ferrara N. PMID: 15548611; PMCID: PMC528996.
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    155. VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J. 2004 Jul 21; 23(14):2800-10. Dong J, Grunstein J, Tejada M, Peale F, Frantz G, Liang WC, Bai W, Yu L, Kowalski J, Liang X, Fuh G, Gerber HP, Ferrara N. PMID: 15229650; PMCID: PMC514949.
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    156. Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation. 2004 Jul-Aug; 11(5):387-96. Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Øie S, Ferrara N, Cohen RL, Shames DM, Brasch RC. PMID: 15280064.
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    158. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004 Jun 03; 350(23):2335-42. Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F. PMID: 15175435.
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    162. Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood. 2004 Jul 01; 104(1):149-58. Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP. PMID: 15016650.
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    165. Neutralizing VEGF bioactivity with a soluble chimeric VEGF-receptor protein flt(1-3)IgG inhibits testosterone-stimulated prostate growth in castrated mice. Prostate. 2004 Jan 01; 58(1):57-65. Lissbrant IF, Hammarsten P, Lissbrant E, Ferrara N, Rudolfsson SH, Bergh A. PMID: 14673953.
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    166. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist. 2004; 9 Suppl 1:2-10. Ferrara N. PMID: 15178810.
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    229. Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo. Prostate. 1998 Apr 01; 35(1):1-10. Borgström P, Bourdon MA, Hillan KJ, Sriramarao P, Ferrara N. PMID: 9537593.
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    246. Crystallization of the receptor binding domain of vascular endothelial growth factor. Proteins. 1996 Nov; 26(3):353-7. Christinger HW, Muller YA, Berleau LT, Keyt BA, Cunningham BC, Ferrara N, de Vos AM. PMID: 8953654.
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    248. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2165-76. Takagi H, King GL, Robinson GS, Ferrara N, Aiello LP. PMID: 8843903.
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    253. Hepatocyte growth factor. A cytokine mediating endothelial migration in inflammatory arthritis. Arthritis Rheum. 1996 Sep; 39(9):1566-75. Koch AE, Halloran MM, Hosaka S, Shah MR, Haskell CJ, Baker SK, Panos RJ, Haines GK, Bennett GL, Pope RM, Ferrara N. PMID: 8814069.
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    254. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch Ophthalmol. 1996 Aug; 114(8):964-70. Tolentino MJ, Miller JW, Gragoudas ES, Chatzistefanou K, Ferrara N, Adamis AP. PMID: 8694732.
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    255. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 1996 Aug; 81(8):3112-8. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN. PMID: 8768883.
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    286. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol. 1994 Apr 15; 152(8):4149-56. Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N. PMID: 7511670.
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    287. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem. 1994 Mar 04; 269(9):6271-4. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K. PMID: 8119973.
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    288. In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells. Exp Cell Res. 1994 Feb; 210(2):298-305. Pepper MS, Wasi S, Ferrara N, Orci L, Montesano R. PMID: 7507853.
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    289. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest. 1994 Feb; 93(2):662-70. Takeshita S, Zheng LP, Brogi E, Kearney M, Pu LQ, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7509344; PMCID: PMC293894.
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    290. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell. 1993 Dec; 4(12):1317-26. Park JE, Keller GA, Ferrara N. PMID: 8167412; PMCID: PMC275767.
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    291. Vascular endothelial growth factor. Trends Cardiovasc Med. 1993 Nov-Dec; 3(6):244-50. Ferrara N. PMID: 21244915.
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    292. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7533-7. Quinn TP, Peters KG, De Vries C, Ferrara N, Williams LT. PMID: 8356051; PMCID: PMC47176.
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    293. Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology. 1993 Aug; 133(2):848-59. Jakeman LB, Armanini M, Phillips HS, Ferrara N. PMID: 7688292.
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    294. Intense focal expression of vascular endothelial growth-factor messenger-RNA in human intracranial neoplasms - association with regions of necrosis. Int J Oncol. 1993 Jun; 2(6):913-9. Phillips H, Armani M, Stavrou D, Ferrara N, Westphal M. PMID: 21573646.
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    295. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 1993 Apr 29; 362(6423):841-4. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. PMID: 7683111.
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    296. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J Clin Invest. 1993 Jan; 91(1):160-70. Ferrara N, Winer J, Burton T, Rowland A, Siegel M, Phillips HS, Terrell T, Keller GA, Levinson AD. PMID: 8423215; PMCID: PMC330010.
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    297. Leukemia inhibitory factor expression in human carotid plaques: possible mechanism for inhibition of large vessel endothelial regrowth. Growth Factors. 1993; 9(4):301-5. Gillett NA, Lowe D, Lu L, Chan C, Ferrara N. PMID: 8148158.
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    298. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem. 1992 Dec 25; 267(36):26031-7. Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. PMID: 1464614.
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    299. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):824-31. Pepper MS, Ferrara N, Orci L, Montesano R. PMID: 1281999.
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    300. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol. 1992 Dec; 153(3):557-62. Unemori EN, Ferrara N, Bauer EA, Amento EP. PMID: 1447317.
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    301. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology. 1992 Jul; 131(1):254-60. Ravindranath N, Little-Ihrig L, Phillips HS, Ferrara N, Zeleznik AJ. PMID: 1612003.
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    302. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992 Feb 21; 255(5047):989-91. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. PMID: 1312256.
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    303. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev. 1992 Feb; 13(1):18-32. Ferrara N, Houck K, Jakeman L, Leung DW. PMID: 1372863.
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    304. Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor. Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):698-702. Ferrara N, Winer J, Henzel WJ. PMID: 1370585; PMCID: PMC48306.
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    305. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors. 1992; 7(1):53-64. Kim KJ, Li B, Houck K, Winer J, Ferrara N. PMID: 1380254.
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    306. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest. 1992 Jan; 89(1):244-53. Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N. PMID: 1729274; PMCID: PMC442842.
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    307. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun. 1991 Dec 16; 181(2):902-6. Pepper MS, Ferrara N, Orci L, Montesano R. PMID: 1755866.
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    308. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol. 1991 Dec; 5(12):1806-14. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. PMID: 1791831.
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    309. The vascular endothelial growth factor family of polypeptides. J Cell Biochem. 1991 Nov; 47(3):211-8. Ferrara N, Houck KA, Jakeman LB, Winer J, Leung DW. PMID: 1791185.
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    310. The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells. Endocrinology. 1991 Aug; 129(2):896-900. Ferrara N, Clapp C, Weiner R. PMID: 1855480.
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    311. Purification and cloning of vascular endothelial growth factor secreted by pituitary folliculostellate cells. Methods Enzymol. 1991; 198:391-405. Ferrara N, Leung DW, Cachianes G, Winer J, Henzel WJ. PMID: 1857232.
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    312. Aortic smooth muscle cells express and secrete vascular endothelial growth factor. Growth Factors. 1991; 5(2):141-8. Ferrara N, Winer J, Burton T. PMID: 1768437.
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    313. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology. 1990 Aug; 127(2):965-7. Phillips HS, Hains J, Leung DW, Ferrara N. PMID: 2197082.
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    314. Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor. Growth Factors. 1990; 4(1):53-9. Rosenthal RA, Megyesi JF, Henzel WJ, Ferrara N, Folkman J. PMID: 2085441.
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    315. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989 Dec 08; 246(4935):1306-9. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. PMID: 2479986.
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    316. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun. 1989 Jun 15; 161(2):851-8. Ferrara N, Henzel WJ. PMID: 2735925.
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    317. Fibroblast growth factor and the control of pituitary and gonad development and function. J Steroid Biochem. 1989 Jan; 32(1B):183-91. Gospodarowicz D, Ferrara N. PMID: 2643740.
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    318. Regulation of ion transport in hypophysial pars intermedia follicular cell monolayers. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):1376-82. Ferrara N, Gospodarowicz D. PMID: 2462871.
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    319. Bovine brain astrocytes express basic fibroblast growth factor, a neurotropic and angiogenic mitogen. Brain Res. 1988 Oct 18; 462(2):223-32. Ferrara N, Ousley F, Gospodarowicz D. PMID: 3191384.
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    320. Basic fibroblast growth factor: expression in cultured cells derived from corneal endothelium and lens epithelium. Exp Eye Res. 1988 Jan; 46(1):71-80. Schweigerer L, Ferrara N, Haaparanta T, Neufeld G, Gospodarowicz D. PMID: 2893740.
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    321. Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology. 1987 Aug; 121(2):597-603. Neufeld G, Ferrara N, Schweigerer L, Mitchell R, Gospodarowicz D. PMID: 3036478.
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    322. Pituitary follicular cells produce basic fibroblast growth factor. Proc Natl Acad Sci U S A. 1987 Aug; 84(16):5773-7. Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D. PMID: 2441393; PMCID: PMC298945.
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    323. Structural characterization and biological functions of fibroblast growth factor. Endocr Rev. 1987 May; 8(2):95-114. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G. PMID: 2440668.
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    324. Transport epithelial characteristics of cultured bovine pituitary follicular cells. Am J Physiol. 1987 Mar; 252(3 Pt 1):E304-12. Ferrara N, Fujii DK, Goldsmith PC, Widdicombe JH, Weiner RI. PMID: 2881486.
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    325. Culture and characterization of follicular cells of the bovine anterior pituitary and pars tuberalis. Methods Enzymol. 1986; 124:245-53. Ferrara N, Goldsmith P, Fujii D, Weiner R. PMID: 3520214.
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    326. Prolactin influences sexual behavior during aging. J Endocrinol Invest. 1985; 8 Suppl 2:23-32. Ferrara N, Bernardini R, Nicoletti F, Drago F, Matera M, Ceravolo A, Scapagnini U. PMID: 4031395.
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    327. Influence of sex steroids and prolactin on haloperidol-induced catalepsy. Brain Res. 1983 Nov 21; 279(1-2):352-8. Nicoletti F, Ferrara N, Patti F, Viglianesi M, Rampello L, Bianchi A, Reggio A, Scapagnini U. PMID: 6315179.
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