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Napoleone Ferrara

Title(s)Professor, Pathology
SchoolHealth Sciences
Address9500 Gilman Drive #0819
La Jolla CA 92093
Phone858-822-6822
Emailnferrara@ucsd.edu
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    Collapse Biography 
    Collapse Education and Training
    University of Catania Medical SchoolM.D.1981Medicine and Surgery
    UCSF, San Francisco, CAPostdoctoral Fellowship1983-85Reproductive Endocrinology
    Oregon Health Sciences University, Portland, ORInternship 1985-86
    UCSF, San Francisco, CAPostdoctoral Fellowship1986-88Cancer Research
    Collapse Awards and Honors
    2019G.B. Bietti Medal
    2015Elected to the National Academy of Medicine
    2015Leslie Dana Gold Medal
    2014Gairdner Foundation Int’l Award
    2014A. Champalimaud Vision Award
    2013Breakthrough Prize in Life Sciences
    2013Elected Fellow, AACR Academy
    2012The Economist Innovation Award
    2011Dr. Paul Janssen Award
    2010Lasker Award
    2009Pezcoller Foundation/AACR International Award
    2008Macula Society-Arnall Patz Award
    2007ASCO Science of Oncology Award
    2006Elected to the National Academy of Sciences
    2006General Motors Cancer Research Award
    2006Passano Award
    2005Lefoulon-Delalande-Institut-de France Prize
    2005AACR Bruce F. Cain Memorial Award
    2004Italian Assoc. Res. Therapy Eye Disorders (AIRCMO) Prize
    2004American-Italian Cancer Foundation Prize

    Collapse Overview 
    Collapse Overview
    Napoleone Ferrara, M.D., is currently Distinguished Professor of Pathology and Adjunct Professor of Ophthalmology and Pharmacology. His main research interests are the biology of angiogenesis and the identification of its regulators. In 1989, while at Genentech, Inc., he reported the isolation and cloning of vascular endothelial growth factor (VEGF) and subsequently focused his research on the investigation of the molecular and biological properties of VEGF. These studies established VEGF as a key regulator of normal and pathological angiogenesis. Together with his colleagues, he reported that VEGF inhibition results in suppression of growth of a variety of tumors in vivo. These findings represented the first direct evidence that inhibition of angiogenesis can block tumor growth and led to the development of a humanized anti-VEGF monoclonal antibody (Bevacizumab) as a cancer therapy. Bevacizumab has been approved by the USA FDA for 11 indications in multiple cancer types. The discovery that VEGF is a key mediator of angiogenesis associated with intraocular neovascular syndromes resulted in the clinical development of a humanized anti-VEGF Fab (Ranibizumab), which has been approved for therapy of neovascular age-related macular degeneration (AMD) and other ocular vascular disorders. Ranibizumab and other anti-VEGF agents represent the first effective therapy for such blinding disorders and rank among the most widely used drugs in older adults.

    Collapse Research 
    Collapse Research Activities and Funding
    Novel Long-Acting Inhibitors of Vascular Endothelial Growth Factor (VEGF) for Treatment of Intraocular Vascular Disorders
    NIH/NEI R01EY031345Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Identification of novel inhibitors of ocular neovascularization
    NIH/NEI R21EY028701Apr 1, 2018 - Mar 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019 03 07; 176(6):1248-1264. Apte RS, Chen DS, Ferrara N. PMID: 30849371.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    2. Interleukin-22 promotes tumor angiogenesis. Angiogenesis. 2019 05; 22(2):311-323. Protopsaltis NJ, Liang W, Nudleman E, Ferrara N. PMID: 30539314.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Metastatic growth instructed by neutrophil-derived transferrin. Proc Natl Acad Sci U S A. 2018 10 23; 115(43):11060-11065. Liang W, Li Q, Ferrara N. PMID: 30301793.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. PMID: 29766399.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    5. Introduction by the Guest Editors: Bevacizumab. Cancer J. 2018 Jul/Aug; 24(4):163-164. Ferrara N, Chen DS. PMID: 30119078.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis. Physiol Rev. 2018 04 01; 98(2):1055-1082. Negri L, Ferrara N. PMID: 29537336.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. Nat Commun. 2017 11 17; 8(1):1574. Eilken HM, Diéguez-Hurtado R, Schmidt I, Nakayama M, Jeong HW, Arf H, Adams S, Ferrara N, Adams RH. PMID: 29146905.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    8. Microvascular Density as a Predictive Biomarker for Bevacizumab Survival Benefit in Ovarian Cancer: Back to First Principles? J Natl Cancer Inst. 2017 11 01; 109(11). Ferrara N. PMID: 29059427.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol. 2017 Aug; 19(8):915-927. Pitulescu ME, Schmidt I, Giaimo BD, Antoine T, Berkenfeld F, Ferrante F, Park H, Ehling M, Biljes D, Rocha SF, Langen UH, Stehling M, Nagasawa T, Ferrara N, Borggrefe T, Adams RH. PMID: 28714968.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    10. Evidence for Pro-angiogenic Functions of VEGF-Ax. Cell. 2016 Sep 22; 167(1):275-284.e6. Xin H, Zhong C, Nudleman E, Ferrara N. PMID: 27662093.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. Commentary on "Humanization of an Anti-VEGF Monoclonal Antibody for the Therapy of Solid Tumors and Other Disorders". Cancer Res. 2016 09 01; 76(17):4913-5. Ferrara N. PMID: 27587649.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 Aug 25; 166(5):1338-1340. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. PMID: 27565353.
      View in: PubMed   Mentions: 5     Fields:    
    13. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 May 05; 165(4):882-95. Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. PMID: 27133169.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    14. VEGF and Intraocular Neovascularization: From Discovery to Therapy. Transl Vis Sci Technol. 2016 Mar; 5(2):10. Ferrara N. PMID: 26981332.
      View in: PubMed   Mentions:
    15. Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model. Neuro Oncol. 2016 07; 18(7):939-49. Osterberg N, Ferrara N, Vacher J, Gaedicke S, Niedermann G, Weyerbrock A, Doostkam S, Schaefer HE, Plate KH, Machein MR. PMID: 26951383.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis. Cancer Immunol Res. 2016 Feb; 4(2):83-91. Liang W, Ferrara N. PMID: 26839309.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    17. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016 06; 15(6):385-403. Ferrara N, Adamis AP. PMID: 26775688.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    18. Outer retinal tubulations response to anti-VEGF treatment. Br J Ophthalmol. 2016 06; 100(6):819-23. Espina M, Arcinue CA, Ma F, Camacho N, Barteselli G, Mendoza N, Ferrara N, Freeman WR. PMID: 26423451.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. Cancer Cell. 2015 Jun 08; 27(6):780-96. Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R. PMID: 26058077.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Inhibition of protein kinase C enhances angiogenesis induced by platelet-derived growth factor C in hyperglycemic endothelial cells. Cardiovasc Diabetol. 2015 Feb 07; 14:19. Moriya J, Ferrara N. PMID: 25849290.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice. PLoS One. 2015; 10(2):e0116332. Sargent KM, Lu N, Clopton DT, Pohlmeier WE, Brauer VM, Ferrara N, Silversides DW, Cupp AS. PMID: 25658474.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Comparison of binding characteristics and in vitro activities of three inhibitors of vascular endothelial growth factor A. Mol Pharm. 2014 Oct 06; 11(10):3421-30. Yang J, Wang X, Fuh G, Yu L, Wakshull E, Khosraviani M, Day ES, Demeule B, Liu J, Shire SJ, Ferrara N, Yadav S. PMID: 25162961.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. A conversation with Napoleone Ferrara. J Clin Invest. 2014 Aug; 124(8):3275-6. Ferrara N, Neill US. PMID: 25083827.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. VEGF modulates synaptic activity in the developing spinal cord. Dev Neurobiol. 2014 Nov; 74(11):1110-22. Guérit S, Allain AE, Léon C, Cazenave W, Ferrara N, Branchereau P, Bikfalvi A. PMID: 24782305.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. Inhibiting the response to VEGF in diabetes. Sci Signal. 2014 Jan 07; 7(307):pe1. Moriya J, Ferrara N. PMID: 24399294.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development. 2014 Jan; 141(2):448-59. Fan J, Ponferrada VG, Sato T, Vemaraju S, Fruttiger M, Gerhardt H, Ferrara N, Lang RA. PMID: 24353059.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia. Endocrinology. 2013 Dec; 154(12):4790-802. Lu N, Sargent KM, Clopton DT, Pohlmeier WE, Brauer VM, McFee RM, Weber JS, Ferrara N, Silversides DW, Cupp AS. PMID: 24169552.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy. Nat Med. 2013 Sep; 19(9):1114-23. Chung AS, Wu X, Zhuang G, Ngu H, Kasman I, Zhang J, Vernes JM, Jiang Z, Meng YG, Peale FV, Ouyang W, Ferrara N. PMID: 23913124.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    29. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013 Sep; 5(9):1415-30. Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. PMID: 23853117.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    30. Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice. J Vasc Surg. 2014 May; 59(5):1402-9.e1-4. Moriya J, Wu X, Zavala-Solorio J, Ross J, Liang XH, Ferrara N. PMID: 23856609.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    31. Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Neoplasia. 2013 Jul; 15(7):694-711. Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA. PMID: 23814482.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. Development and preclinical characterization of a humanized antibody targeting CXCL12. Clin Cancer Res. 2013 Aug 15; 19(16):4433-45. Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N. PMID: 23812669.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife. 2013 Jun 18; 2:e00324. Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK. PMID: 23795287.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    34. Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies. Clin Cancer Res. 2013 Jul 01; 19(13):3681-92. Brauer MJ, Zhuang G, Schmidt M, Yao J, Wu X, Kaminker JS, Jurinka SS, Kolumam G, Chung AS, Jubb A, Modrusan Z, Ozawa T, James CD, Phillips H, Haley B, Tam RN, Clermont AC, Cheng JH, Yang SX, Swain SM, Chen D, Scherer SJ, Koeppen H, Yeh RF, Yue P, Stephan JP, Hegde P, Ferrara N, Singh M, Bais C. PMID: 23685835.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    35. Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases. Sci Signal. 2013 Apr 16; 6(271):ra25. Zhuang G, Yu K, Jiang Z, Chung A, Yao J, Ha C, Toy K, Soriano R, Haley B, Blackwood E, Sampath D, Bais C, Lill JR, Ferrara N. PMID: 23592840.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    36. Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):6079-84. Phan VT, Wu X, Cheng JH, Sheng RX, Chung AS, Zhuang G, Tran C, Song Q, Kowanetz M, Sambrone A, Tan M, Meng YG, Jackson EL, Peale FV, Junttila MR, Ferrara N. PMID: 23530240.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    37. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. PMID: 23452854.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    38. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013 Feb 14; 494(7436):243-6. Rao S, Chun C, Fan J, Kofron JM, Yang MB, Hegde RS, Ferrara N, Copenhagen DR, Lang RA. PMID: 23334418.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    39. Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood. 2013 Mar 28; 121(13):2574-8. Stefater JA, Rao S, Bezold K, Aplin AC, Nicosia RF, Pollard JW, Ferrara N, Lang RA. PMID: 23303818.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    40. Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell. 2012 Oct 12; 151(2):384-99. Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK, Jeansson M, Zhang C, Tucholska M, Jones N, Kerjaschki D, Shibuya M, Fantus IG, Nagy A, Gerber HP, Ferrara N, Pawson T, Quaggin SE. PMID: 23063127.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    41. Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology. 2013 Jan; 120(1):106-14. Miller JW, Le Couter J, Strauss EC, Ferrara N. PMID: 23031671.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    42. S1P1 inhibits sprouting angiogenesis during vascular development. Development. 2012 Oct; 139(20):3859-69. Ben Shoham A, Malkinson G, Krief S, Shwartz Y, Ely Y, Ferrara N, Yaniv K, Zelzer E. PMID: 22951644.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    43. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. 1989. Biochem Biophys Res Commun. 2012 Aug 31; 425(3):540-7. Ferrara N, Henzel WJ. PMID: 22925671.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    44. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 2012 Sep; 122(9):3101-13. Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR. PMID: 22886301.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    45. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat Biotechnol. 2012 Jul 10; 30(7):648-57. Singh M, Ferrara N. PMID: 22781694.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    46. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012 Aug 29; 31(17):3513-23. Zhuang G, Wu X, Jiang Z, Kasman I, Yao J, Guan Y, Oeh J, Modrusan Z, Bais C, Sampath D, Ferrara N. PMID: 22773185.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    47. Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J Pathol. 2012 Aug; 227(4):404-16. Chung AS, Kowanetz M, Wu X, Zhuang G, Ngu H, Finkle D, Komuves L, Peale F, Ferrara N. PMID: 22611017.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    48. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J Pathol. 2012 Aug; 227(4):417-30. Singh M, Couto SS, Forrest WF, Lima A, Cheng JH, Molina R, Long JE, Hamilton P, McNutt A, Kasman I, Nannini MA, Reslan HB, Cao TC, Ho CC, Barck KH, Carano RA, Foreman O, Eastham-Anderson J, Jubb AM, Ferrara N, Johnson L. PMID: 22611036.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    49. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012 Jul; 122(7):2454-68. Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. PMID: 22653056.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    50. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood. 2012 Jul 19; 120(3):613-25. Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA. PMID: 22577176.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    51. Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. J Biol Chem. 2012 Jun 01; 287(23):19574-84. Qu X, Zhuang G, Yu L, Meng G, Ferrara N. PMID: 22528488.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    52. The heart endocardium is derived from vascular endothelial progenitors. Development. 2011 Nov; 138(21):4777-87. Milgrom-Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans SM, Tzahor E. PMID: 21989917.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    53. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol. 2011; 27:563-84. Chung AS, Ferrara N. PMID: 21756109.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    54. Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11590-5. Yao J, Wu X, Zhuang G, Kasman IM, Vogt T, Phan V, Shibuya M, Ferrara N, Bais C. PMID: 21709213.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    55. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 2011 May 29; 474(7352):511-5. Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, Lang RA. PMID: 21623369.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    56. Multiple effects of angiopoietin-2 blockade on tumors. Cancer Cell. 2011 Apr 12; 19(4):431-3. Lewis CE, Ferrara N. PMID: 21481783.
      View in: PubMed   Mentions: 6     Fields:    
    57. Comparing protein VEGF inhibitors: In vitro biological studies. Biochem Biophys Res Commun. 2011 May 06; 408(2):276-81. Yu L, Liang XH, Ferrara N. PMID: 21501594.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    58. From the discovery of vascular endothelial growth factor to the introduction of avastin in clinical trials - an interview with Napoleone Ferrara by Domenico Ribatti. Int J Dev Biol. 2011; 55(4-5):383-8. Ferrara N. PMID: 21858763.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    59. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21248-55. Kowanetz M, Wu X, Lee J, Tan M, Hagenbeek T, Qu X, Yu L, Ross J, Korsisaari N, Cao T, Bou-Reslan H, Kallop D, Weimer R, Ludlam MJ, Kaminker JS, Modrusan Z, van Bruggen N, Peale FV, Carano R, Meng YG, Ferrara N. PMID: 21081700.
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    137. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004 Jun 03; 350(23):2335-42. Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F. PMID: 15175435.
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    139. VEGFA is necessary for chondrocyte survival during bone development. Development. 2004 May; 131(9):2161-71. Zelzer E, Mamluk R, Ferrara N, Johnson RS, Schipani E, Olsen BR. PMID: 15073147.
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    140. Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood. 2004 Jul 01; 104(1):149-58. Hesser BA, Liang XH, Camenisch G, Yang S, Lewin DA, Scheller R, Ferrara N, Gerber HP. PMID: 15016650.
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    141. EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors. Biochim Biophys Acta. 2004 Mar 04; 1654(1):69-78. Ferrara N, LeCouter J, Lin R, Peale F. PMID: 14984768.
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    142. Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor. Thromb Haemost. 2004 Mar; 91(3):595-605. Raab S, Beck H, Gaumann A, Yüce A, Gerber HP, Plate K, Hammes HP, Ferrara N, Breier G. PMID: 14983237.
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    143. Neutralizing VEGF bioactivity with a soluble chimeric VEGF-receptor protein flt(1-3)IgG inhibits testosterone-stimulated prostate growth in castrated mice. Prostate. 2004 Jan 01; 58(1):57-65. Lissbrant IF, Hammarsten P, Lissbrant E, Ferrara N, Rudolfsson SH, Bergh A. PMID: 14673953.
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    144. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist. 2004; 9 Suppl 1:2-10. Ferrara N. PMID: 15178810.
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    145. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol. 2003 Oct 15; 262(2):225-41. Haigh JJ, Morelli PI, Gerhardt H, Haigh K, Tsien J, Damert A, Miquerol L, Muhlner U, Klein R, Ferrara N, Wagner EF, Betsholtz C, Nagy A. PMID: 14550787.
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    146. EG-VEGF and Bv8. a novel family of tissue-selective mediators of angiogenesis, endothelial phenotype, and function. Trends Cardiovasc Med. 2003 Oct; 13(7):276-82. LeCouter J, Ferrara N. PMID: 14522467.
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    147. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell. 2003 Aug; 4(2):133-46. Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber HP, Johnson RS, Bergers G. PMID: 12957288.
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    148. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol. 2003 Jun 17; 13(12):1070-4. Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA. PMID: 12814555.
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    149. Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries. Am J Pathol. 2003 Jun; 162(6):1881-93. Ferrara N, Frantz G, LeCouter J, Dillard-Telm L, Pham T, Draksharapu A, Giordano T, Peale F. PMID: 12759245.
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    150. The biology of VEGF and its receptors. Nat Med. 2003 Jun; 9(6):669-76. Ferrara N, Gerber HP, LeCouter J. PMID: 12778165.
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    151. Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis. Endocrinology. 2003 Jun; 144(6):2606-16. LeCouter J, Lin R, Frantz G, Zhang Z, Hillan K, Ferrara N. PMID: 12746324.
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    152. Diabetic patients and retinal proliferation: an evaluation of the role of vascular endothelial growth factor (VEGF). Exp Clin Endocrinol Diabetes. 2003 Jun; 111(4):209-14. Nicoletti VG, Nicoletti R, Ferrara N, Meli G, Reibaldi M, Reibaldi A. PMID: 12845559.
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    153. Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Exp Cell Res. 2003 May 01; 285(2):286-98. Tille JC, Wang X, Lipson KE, McMahon G, Ferrara N, Zhu Z, Hicklin DJ, Sleeman JP, Eriksson U, Alitalo K, Pepper MS. PMID: 12706123.
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    154. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003 Mar 07; 112(5):645-57. Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. PMID: 12628185.
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    155. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 2003 Mar; 111(5):707-16. Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber HP, Kikkawa Y, Miner JH, Quaggin SE. PMID: 12618525.
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    156. The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2685-90. LeCouter J, Lin R, Tejada M, Frantz G, Peale F, Hillan KJ, Ferrara N. PMID: 12604792.
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    157. Angiogenesis-independent endothelial protection of liver: role of VEGFR-1. Science. 2003 Feb 07; 299(5608):890-3. LeCouter J, Moritz DR, Li B, Phillips GL, Liang XH, Gerber HP, Hillan KJ, Ferrara N. PMID: 12574630.
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    158. The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med (Berl). 2003 Jan; 81(1):20-31. Gerber HP, Ferrara N. PMID: 12545246.
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    159. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin Oncol. 2002 Dec; 29(6 Suppl 16):10-4. Ferrara N. PMID: 12516033.
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    160. Endocrine gland vascular endothelial growth factor (EG-VEGF) and the hypothesis of tissue-specific regulation of angiogenesis. Endocr Res. 2002 Nov; 28(4):763-4. Ferrara N, LeCouter J, Lin R. PMID: 12530695.
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    161. Vascular endothelial growth factor immunoneutralization plus Paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer. Am J Pathol. 2002 Nov; 161(5):1917-24. Hu L, Hofmann J, Zaloudek C, Ferrara N, Hamilton T, Jaffe RB. PMID: 12414537.
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    162. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer. 2002 Oct; 2(10):795-803. Ferrara N. PMID: 12360282.
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    164. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9656-61. Street J, Bao M, deGuzman L, Bunting S, Peale FV, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, van Bruggen N, Redmond HP, Carano RA, Filvaroff EH. PMID: 12118119.
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    165. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature. 2002 Jun 27; 417(6892):954-8. Gerber HP, Malik AK, Solar GP, Sherman D, Liang XH, Meng G, Hong K, Marsters JC, Ferrara N. PMID: 12087404.
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    166. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell. 2002 Mar; 1(2):193-202. Inoue M, Hager JH, Ferrara N, Gerber HP, Hanahan D. PMID: 12086877.
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    167. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. J Biol Chem. 2002 May 10; 277(19):17281-90. Camenisch G, Pisabarro MT, Sherman D, Kowalski J, Nagel M, Hass P, Xie MH, Gurney A, Bodary S, Liang XH, Clark K, Beresini M, Ferrara N, Gerber HP. PMID: 11877390.
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    169. VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Am J Physiol Regul Integr Comp Physiol. 2002 Jan; 282(1):R199-206. Clyman RI, Seidner SR, Kajino H, Roman C, Koch CJ, Ferrara N, Waleh N, Mauray F, Chen YQ, Perkett EA, Quinn T. PMID: 11742839.
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    170. The role of EG-VEGF in the regulation of angiogenesis in endocrine glands. Cold Spring Harb Symp Quant Biol. 2002; 67:217-21. LeCouter J, Lin R, Ferrara N. PMID: 12858543.
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    171. Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells. J Biol Chem. 2002 Mar 08; 277(10):8724-9. Lin R, LeCouter J, Kowalski J, Ferrara N. PMID: 11751915.
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    172. Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice. J Magn Reson Imaging. 2001 Oct; 14(4):374-82. Williams SP, Gerber HP, Giordano FJ, Peale FV, Bernstein LJ, Bunting S, Chien KR, Ferrara N, van Bruggen N. PMID: 11599061.
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    173. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J Virol. 2001 Oct; 75(20):9828-35. Zheng M, Deshpande S, Lee S, Ferrara N, Rouse BT. PMID: 11559816.
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    174. Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature. 2001 Aug 30; 412(6850):877-84. LeCouter J, Kowalski J, Foster J, Hass P, Zhang Z, Dillard-Telm L, Frantz G, Rangell L, DeGuzman L, Keller GA, Peale F, Gurney A, Hillan KJ, Ferrara N. PMID: 11528470.
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    175. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 2001 Jun; 280(6):C1358-66. Ferrara N. PMID: 11350730.
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    176. Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. J Natl Cancer Inst. 2001 May 16; 93(10):762-8. Hu YL, Tee MK, Goetzl EJ, Auersperg N, Mills GB, Ferrara N, Jaffe RB. PMID: 11353786.
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    177. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5780-5. Giordano FJ, Gerber HP, Williams SP, VanBruggen N, Bunting S, Ruiz-Lozano P, Gu Y, Nath AK, Huang Y, Hickey R, Dalton N, Peterson KL, Ross J, Chien KR, Ferrara N. PMID: 11331753.
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    178. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol. 2001 Mar; 158(3):1111-20. Xin X, Yang S, Ingle G, Zlot C, Rangell L, Kowalski J, Schwall R, Ferrara N, Gerritsen ME. PMID: 11238059.
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    179. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol. 2001; 106(4):148-56. Ferrara N, Gerber HP. PMID: 11815711.
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    181. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res. 2000 Nov 15; 60(22):6253-8. Gerber HP, Kowalski J, Sherman D, Eberhard DA, Ferrara N. PMID: 11103779.
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    182. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J Biol Chem. 2001 Feb 02; 276(5):3222-30. Gille H, Kowalski J, Li B, LeCouter J, Moffat B, Zioncheck TF, Pelletier N, Ferrara N. PMID: 11058584.
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    183. Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered microvascular permeability after inhibition of vascular endothelial growth factor. Am J Obstet Gynecol. 2000 Oct; 183(4):956-63. Gossmann A, Helbich TH, Mesiano S, Shames DM, Wendland MF, Roberts TP, Ferrara N, Jaffe RB, Brasch RC. PMID: 11035346.
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    184. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000 Oct 01; 60(19):5565-70. Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y. PMID: 11034104.
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    185. VEGF regulates cell behavior during vasculogenesis. Dev Biol. 2000 Aug 15; 224(2):178-88. Drake CJ, LaRue A, Ferrara N, Little CD. PMID: 10926758.
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    186. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration. EMBO J. 2000 Aug 01; 19(15):4064-73. Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N. PMID: 10921887.
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    187. Angiogenesis and bone growth. Trends Cardiovasc Med. 2000 Jul; 10(5):223-8. Gerber HP, Ferrara N. PMID: 11282299.
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    188. Formation of endothelial cell networks. Nature. 2000 May 11; 405(6783):139-41. Helmlinger G, Endo M, Ferrara N, Hlatky L, Jain RK. PMID: 10821260.
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    189. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development. 2000 Apr; 127(7):1445-53. Haigh JJ, Gerber HP, Ferrara N, Wagner EF. PMID: 10704390.
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    193. Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res. 1999 Sep-Oct; 19(5B):4203-14. Borgström P, Gold DP, Hillan KJ, Ferrara N. PMID: 10628376.
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    194. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int. 1999 Sep; 56(3):794-814. Ferrara N. PMID: 10469350.
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    195. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol Pathol. 1999 Sep-Oct; 27(5):536-44. Mordenti J, Cuthbertson RA, Ferrara N, Thomsen K, Berleau L, Licko V, Allen PC, Valverde CR, Meng YG, Fei DT, Fourre KM, Ryan AM. PMID: 10528633.
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    197. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med. 1999 Jun; 5(6):623-8. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. PMID: 10371499.
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    198. VEGF is required for growth and survival in neonatal mice. Development. 1999 Mar; 126(6):1149-59. Gerber HP, Hillan KJ, Ryan AM, Kowalski J, Keller GA, Rangell L, Wright BD, Radtke F, Aguet M, Ferrara N. PMID: 10021335.
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    199. Oncogenic ras fails to restore an in vivo tumorigenic phenotype in embryonic stem cells lacking vascular endothelial growth factor (VEGF). Biochem Biophys Res Commun. 1999 Jan 19; 254(2):480-3. Shi YP, Ferrara N. PMID: 9918864.
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    209. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med. 1998 Mar; 4(3):336-40. Ferrara N, Chen H, Davis-Smyth T, Gerber HP, Nguyen TN, Peers D, Chisholm V, Hillan KJ, Schwall RH. PMID: 9500609.
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    215. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997 Oct 15; 57(20):4593-9. Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N. PMID: 9377574.
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    216. Vascular endothelial growth factor attenuates myocardial ischemia-reperfusion injury. Ann Thorac Surg. 1997 Oct; 64(4):993-8. Luo Z, Diaco M, Murohara T, Ferrara N, Isner JM, Symes JF. PMID: 9354516.
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    217. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem. 1997 Sep 19; 272(38):23659-67. Gerber HP, Condorelli F, Park J, Ferrara N. PMID: 9295307.
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    218. The biology of vascular endothelial growth factor. Endocr Rev. 1997 Feb; 18(1):4-25. Ferrara N, Davis-Smyth T. PMID: 9034784.
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    219. Inhibition of vascular endothelial cell growth factor suppresses the in vivo growth of human prostate tumors. Urol Oncol. 1997 Jan-Feb; 3(1):3-10. Kirschenbaum A, Wang JP, Ren M, Schiff JD, Aaronson SA, Droller MJ, Ferrara N, Holland JF, Levine AC. PMID: 21227046.
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    220. Vascular endothelial growth factor: basic biology and clinical implications. EXS. 1997; 79:209-32. Ferrara N, Keyt B. PMID: 9002234.
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    221. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14765-70. Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. PMID: 8962129.
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    222. Vascular endothelial growth factor. Eur J Cancer. 1996 Dec; 32A(14):2413-22. Ferrara N. PMID: 9059329.
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    223. Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem. 1996 Nov 15; 271(46):29483-8. Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB. PMID: 8910616.
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    224. Crystallization of the receptor binding domain of vascular endothelial growth factor. Proteins. 1996 Nov; 26(3):353-7. Christinger HW, Muller YA, Berleau LT, Keyt BA, Cunningham BC, Ferrara N, de Vos AM. PMID: 8953654.
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    225. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology. 1996 Nov; 103(11):1820-8. Tolentino MJ, Miller JW, Gragoudas ES, Jakobiec FA, Flynn E, Chatzistefanou K, Ferrara N, Adamis AP. PMID: 8942877.
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    226. Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia. Biochem Biophys Res Commun. 1996 Oct 14; 227(2):628-35. Takeshita S, Weir L, Chen D, Zheng LP, Riessen R, Bauters C, Symes JF, Ferrara N, Isner JM. PMID: 8878563.
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    227. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2165-76. Takagi H, King GL, Robinson GS, Ferrara N, Aiello LP. PMID: 8843903.
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    228. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab Invest. 1996 Oct; 75(4):487-501. Takeshita S, Tsurumi Y, Couffinahl T, Asahara T, Bauters C, Symes J, Ferrara N, Isner JM. PMID: 8874381.
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    229. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 1996 Sep 16; 15(18):4919-27. Davis-Smyth T, Chen H, Park J, Presta LG, Ferrara N. PMID: 8890165.
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    230. Natural killer cells, adhesion and tumor angiogenesis. Nat Med. 1996 Sep; 2(9):971-2. Ferrara N. PMID: 8782449.
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    231. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. 1996 Sep 01; 56(17):4032-9. Borgström P, Hillan KJ, Sriramarao P, Ferrara N. PMID: 8752175.
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    232. Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab. 1996 Aug; 81(8):3112-8. Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, Jaffe RB, Taylor RN. PMID: 8768883.
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    233. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch Ophthalmol. 1996 Aug; 114(8):964-70. Tolentino MJ, Miller JW, Gragoudas ES, Chatzistefanou K, Ferrara N, Adamis AP. PMID: 8694732.
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    234. Effects of vascular endothelial growth factor on hemodynamics and cardiac performance. J Cardiovasc Pharmacol. 1996 Jun; 27(6):838-44. Yang R, Thomas GR, Bunting S, Ko A, Ferrara N, Keyt B, Ross J, Jin H. PMID: 8761851.
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    235. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Invest Ophthalmol Vis Sci. 1996 Jun; 37(7):1311-21. Takagi H, King GL, Ferrara N, Aiello LP. PMID: 8641834.
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    236. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 1996 Apr 04; 380(6573):439-42. Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea KS, Powell-Braxton L, Hillan KJ, Moore MW. PMID: 8602242.
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    237. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem. 1996 Mar 29; 271(13):7788-95. Keyt BA, Berleau LT, Nguyen HV, Chen H, Heinsohn H, Vandlen R, Ferrara N. PMID: 8631822.
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    238. Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis. J Biol Chem. 1996 Mar 08; 271(10):5638-46. Keyt BA, Nguyen HV, Berleau LT, Duarte CM, Park J, Chen H, Ferrara N. PMID: 8621427.
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    239. The in vivo bioactivity of vascular endothelial growth factor/vascular permeability factor is independent of N-linked glycosylation. Lab Invest. 1996 Feb; 74(2):546-56. Walter DH, Hink U, Asahara T, Van Belle E, Horowitz J, Tsurumi Y, Vandlen R, Heinsohn H, Keyt B, Ferrara N, Symes JF, Isner JM. PMID: 8780172.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    240. Vascular endothelial growth factor, a specific regulator of angiogenesis. Curr Opin Nephrol Hypertens. 1996 Jan; 5(1):35-44. Ferrara N, Bunting S. PMID: 8834160.
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    241. Vascular endothelial growth factor augments muscle blood flow and function in a rabbit model of chronic hindlimb ischemia. J Cardiovasc Pharmacol. 1996 Jan; 27(1):91-8. Walder CE, Errett CJ, Bunting S, Lindquist P, Ogez JR, Heinsohn HG, Ferrara N, Thomas GR. PMID: 8656665.
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    242. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol. 1996 Jan; 114(1):66-71. Adamis AP, Shima DT, Tolentino MJ, Gragoudas ES, Ferrara N, Folkman J, D'Amore PA, Miller JW. PMID: 8540853.
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    243. Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency. Am J Pathol. 1995 Dec; 147(6):1649-60. Takeshita S, Rossow ST, Kearney M, Zheng LP, Bauters C, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7495290.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    244. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A. 1995 Nov 07; 92(23):10457-61. Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L, Ferrara N, King GL, Smith LE. PMID: 7479819.
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    245. Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo. Circulation. 1995 Nov 01; 92(9 Suppl):II365-71. Asahara T, Bauters C, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7586439.
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    246. Vascular endothelial growth factor. The trigger for neovascularization in the eye. Lab Invest. 1995 Jun; 72(6):615-8. Ferrara N. PMID: 7540232.
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    247. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor. Circulation. 1995 Jun 01; 91(11):2802-9. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7758187.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    248. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation. 1995 Jun 01; 91(11):2793-801. Asahara T, Bauters C, Pastore C, Kearney M, Rossow S, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7758186.
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    249. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem. 1995 Apr 28; 270(17):9709-16. Mandriota SJ, Seghezzi G, Vassalli JD, Ferrara N, Wasi S, Mazzieri R, Mignatti P, Pepper MS. PMID: 7730348.
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    250. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest. 1995 Apr; 95(4):1789-97. Warren RS, Yuan H, Matli MR, Gillett NA, Ferrara N. PMID: 7535799.
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    251. The regulation of blood vessel growth by vascular endothelial growth factor. Ann N Y Acad Sci. 1995 Mar 27; 752:246-56. Ferrara N, Heinsohn H, Walder CE, Bunting S, Thomas GR. PMID: 7538737.
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    252. Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor. J Vasc Surg. 1995 Feb; 21(2):314-24; discussion 324-5. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7531786.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    253. Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med. 1995 Jan; 1(2):182-93. Shima DT, Adamis AP, Ferrara N, Yeo KT, Yeo TK, Allende R, Folkman J, D'Amore PA. PMID: 8529097.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    254. The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat. 1995; 36(2):127-37. Ferrara N. PMID: 8534862.
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    255. Leukemia inhibitory factor (LIF) inhibits angiogenesis in vitro. J Cell Sci. 1995 Jan; 108 ( Pt 1):73-83. Pepper MS, Ferrara N, Orci L, Montesano R. PMID: 7537748.
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    256. Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells. Diabetes. 1995 Jan; 44(1):98-103. Thieme H, Aiello LP, Takagi H, Ferrara N, King GL. PMID: 7529203.
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    257. Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation. 1994 Nov; 90(5 Pt 2):II228-34. Takeshita S, Pu LQ, Stein LA, Sniderman AD, Bunting S, Ferrara N, Isner JM, Symes JF. PMID: 7525111.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    258. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J Biol Chem. 1994 Oct 14; 269(41):25646-54. Park JE, Chen HH, Winer J, Houck KA, Ferrara N. PMID: 7929268.
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    259. Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb. Am J Physiol. 1994 Oct; 267(4 Pt 2):H1263-71. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7943370.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    260. Vascular endothelial growth factor receptor localization and activation in human trophoblast and choriocarcinoma cells. Biol Reprod. 1994 Sep; 51(3):524-30. Charnock-Jones DS, Sharkey AM, Boocock CA, Ahmed A, Plevin R, Ferrara N, Smith SK. PMID: 7803624.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    261. In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action. J Clin Endocrinol Metab. 1994 Jul; 79(1):316-22. Shifren JL, Doldi N, Ferrara N, Mesiano S, Jaffe RB. PMID: 8027247.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    262. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol. 1994 Apr 15; 152(8):4149-56. Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N. PMID: 7511670.
      View in: PubMed   Mentions: 124     Fields:    Translation:Humans
    263. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem. 1994 Mar 04; 269(9):6271-4. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K. PMID: 8119973.
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    264. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest. 1994 Feb; 93(2):662-70. Takeshita S, Zheng LP, Brogi E, Kearney M, Pu LQ, Bunting S, Ferrara N, Symes JF, Isner JM. PMID: 7509344.
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    265. In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells. Exp Cell Res. 1994 Feb; 210(2):298-305. Pepper MS, Wasi S, Ferrara N, Orci L, Montesano R. PMID: 7507853.
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    266. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell. 1993 Dec; 4(12):1317-26. Park JE, Keller GA, Ferrara N. PMID: 8167412.
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    267. Vascular endothelial growth factor. Trends Cardiovasc Med. 1993 Nov-Dec; 3(6):244-50. Ferrara N. PMID: 21244915.
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    268. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7533-7. Quinn TP, Peters KG, De Vries C, Ferrara N, Williams LT. PMID: 8356051.
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    269. Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis. Endocrinology. 1993 Aug; 133(2):848-59. Jakeman LB, Armanini M, Phillips HS, Ferrara N. PMID: 7688292.
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    270. Intense focal expression of vascular endothelial growth-factor messenger-RNA in human intracranial neoplasms - association with regions of necrosis. Int J Oncol. 1993 Jun; 2(6):913-9. Phillips H, Armani M, Stavrou D, Ferrara N, Westphal M. PMID: 21573646.
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    271. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature. 1993 Apr 29; 362(6423):841-4. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. PMID: 7683111.
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    272. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells. J Clin Invest. 1993 Jan; 91(1):160-70. Ferrara N, Winer J, Burton T, Rowland A, Siegel M, Phillips HS, Terrell T, Keller GA, Levinson AD. PMID: 8423215.
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    273. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem. 1992 Dec 25; 267(36):26031-7. Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. PMID: 1464614.
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    274. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):824-31. Pepper MS, Ferrara N, Orci L, Montesano R. PMID: 1281999.
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    275. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol. 1992 Dec; 153(3):557-62. Unemori EN, Ferrara N, Bauer EA, Amento EP. PMID: 1447317.
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    276. Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary. Endocrinology. 1992 Jul; 131(1):254-60. Ravindranath N, Little-Ihrig L, Phillips HS, Ferrara N, Zeleznik AJ. PMID: 1612003.
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    277. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992 Feb 21; 255(5047):989-91. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. PMID: 1312256.
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    278. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev. 1992 Feb; 13(1):18-32. Ferrara N, Houck K, Jakeman L, Leung DW. PMID: 1372863.
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    279. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J Clin Invest. 1992 Jan; 89(1):244-53. Jakeman LB, Winer J, Bennett GL, Altar CA, Ferrara N. PMID: 1729274.
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    280. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors. 1992; 7(1):53-64. Kim KJ, Li B, Houck K, Winer J, Ferrara N. PMID: 1380254.
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    281. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun. 1991 Dec 16; 181(2):902-6. Pepper MS, Ferrara N, Orci L, Montesano R. PMID: 1755866.
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    282. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol. 1991 Dec; 5(12):1806-14. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. PMID: 1791831.
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    283. The vascular endothelial growth factor family of polypeptides. J Cell Biochem. 1991 Nov; 47(3):211-8. Ferrara N, Houck KA, Jakeman LB, Winer J, Leung DW. PMID: 1791185.
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    284. The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells. Endocrinology. 1991 Aug; 129(2):896-900. Ferrara N, Clapp C, Weiner R. PMID: 1855480.
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    285. Aortic smooth muscle cells express and secrete vascular endothelial growth factor. Growth Factors. 1991; 5(2):141-8. Ferrara N, Winer J, Burton T. PMID: 1768437.
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    286. Purification and cloning of vascular endothelial growth factor secreted by pituitary folliculostellate cells. Methods Enzymol. 1991; 198:391-405. Ferrara N, Leung DW, Cachianes G, Winer J, Henzel WJ. PMID: 1857232.
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    287. Vascular endothelial growth factor is expressed in rat corpus luteum. Endocrinology. 1990 Aug; 127(2):965-7. Phillips HS, Hains J, Leung DW, Ferrara N. PMID: 2197082.
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    288. Conditioned medium from mouse sarcoma 180 cells contains vascular endothelial growth factor. Growth Factors. 1990; 4(1):53-9. Rosenthal RA, Megyesi JF, Henzel WJ, Ferrara N, Folkman J. PMID: 2085441.
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    289. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989 Dec 08; 246(4935):1306-9. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. PMID: 2479986.
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    290. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun. 1989 Jun 15; 161(2):851-8. Ferrara N, Henzel WJ. PMID: 2735925.
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    291. Basic fibroblast growth factor: expression in cultured bovine vascular smooth muscle cells. Eur J Cell Biol. 1988 Apr; 46(1):144-51. Gospodarowicz D, Ferrara N, Haaparanta T, Neufeld G. PMID: 3396587.
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    292. Basic fibroblast growth factor: expression in cultured cells derived from corneal endothelium and lens epithelium. Exp Eye Res. 1988 Jan; 46(1):71-80. Schweigerer L, Ferrara N, Haaparanta T, Neufeld G, Gospodarowicz D. PMID: 2893740.
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