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    Robert Rissman

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0624
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      A Blood Test for Screening Into Alzheimer's Prevention Trials
      NIH/NIA R01AG058252Sep 15, 2017 - Jun 30, 2022
      Role: Co-Principal Investigator
      Proteomic characterization of exosomes from AD patients
      NIH/NIA R56AG057459Sep 15, 2017 - Aug 31, 2018
      Role: Co-Principal Investigator
      Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
      NIH/NIA R56AG057469Sep 15, 2017 - Aug 31, 2018
      Role: Principal Investigator
      A Proinflammatory Endophenotype to Predict NSAID Treatment Response Alzheimer's Disease Clinical Trials
      NIH/NIA R01AG051848Sep 1, 2016 - Mar 31, 2021
      Role: Principal Investigator
      Pathogenicity of neuronally-derived tau in exosomes
      NIH/NIA R21AG051839Sep 1, 2016 - Apr 30, 2018
      Role: Principal Investigator
      Validation Studies of CRF Receptor 1 as a Target for AD
      VA I01BX003040Jul 1, 2016 - Jun 30, 2020
      Role: Principal Investigator
      Systems biology of HIV, methamphetamine and antiretrovirals interactions
      NIH/NIDA R01DA041750May 1, 2016 - Apr 30, 2021
      Role: Co-Principal Investigator
      Polytherapy for AD: Combining Gamma-secretase Modulation and CRFR1 Antagonism
      NIH/NIA R21AG047484Sep 1, 2014 - Apr 30, 2016
      Role: Principal Investigator
      Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
      NIH/NIA R01AG032755Aug 15, 2008 - Jul 31, 2014
      Role: Principal Investigator
      Role of Intracellular ABeta in Tau Pathology
      NIH/NIA F32AG023433Jan 1, 2004 - Dec 31, 2004
      Role: Principal Investigator
      B-Synuclein as a Treatment for Lewy Body Disease
      NIH/NIA R01AG018440Sep 1, 2001 - May 31, 2022
      Role: Co-Principal Investigator
      Alzheimer's Disease Cooperative Study
      NIH/NIA U19AG010483Jul 1, 1997 - Feb 28, 2018
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zhang C, Rissman R. Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer's disease mice. PLoS One. 2017; 12(7):e0181367. PMID: 28750017.
        View in: PubMed
      2. Reilly P, Winston CN, Baron KR, Trejo M, Rockenstein EM, Akers JC, Kfoury N, Diamond M, Masliah E, Rissman R, Yuan SH. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiol Dis. 2017 Oct; 106:222-234. PMID: 28610892.
        View in: PubMed
      3. Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, Masliah D, Adame A, Masliah E, Rissman R. Brain-derived exosomes from dementia with Lewy bodies propagate a-synuclein pathology. Acta Neuropathol Commun. 2017 Jun 09; 5(1):46. PMID: 28599681.
        View in: PubMed
      4. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman R, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul; 362(1):31-44. PMID: 28416568.
        View in: PubMed
      5. Relkin NR, Thomas RG, Rissman R, Brewer JB, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS. A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017 May 02; 88(18):1768-1775. PMID: 28381506.
        View in: PubMed
      6. Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman R, Masliah E. Anti-a-synuclein immunotherapy reduces a-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 Jan 13; 5(1):7. PMID: 28086964.
        View in: PubMed
      7. Moussa C, Hebron M, Huang X, Ahn J, Rissman R, Aisen PS, Turner RS. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. J Neuroinflammation. 2017 Jan 03; 14(1):1. PMID: 28086917.
        View in: PubMed
      8. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman R, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. PMID: 28946567.
        View in: PubMed
      9. Sokolow S, Li X, Chen L, D Taylor K, Rotter JI, Rissman R, Aisen PS, Apostolova LG. Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment. J Alzheimers Dis. 2016 Nov 29. PMID: 27911294.
        View in: PubMed
      10. Zlatar ZZ, Bischoff-Grethe A, Hays CC, Liu TT, Meloy MJ, Rissman R, Bondi MW, Wierenga CE. Higher Brain Perfusion May Not Support Memory Functions in Cognitively Normal Carriers of the ApoE e4 Allele Compared to Non-Carriers. Front Aging Neurosci. 2016; 8:151. PMID: 27445794; PMCID: PMC4919360.
      11. Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman R, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. PMID: 28642933.
        View in: PubMed
      12. Winston CN, Goetzl EJ, Akers JC, Carter BS, Rockenstein EM, Galasko D, Masliah E, Rissman R. Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile. Alzheimers Dement (Amst). 2016; 3:63-72. PMID: 27408937; PMCID: PMC4925777.
      13. Le MH, Weissmiller AM, Monte L, Lin PH, Hexom TC, Natera O, Wu C, Rissman R. Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLoS One. 2016; 11(1):e0147250. PMID: 26790099; PMCID: PMC4720402.
      14. Zhang C, Kuo CC, Moghadam SH, Monte L, Campbell SN, Rice KC, Sawchenko PE, Masliah E, Rissman R. Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. 2016 May; 12(5):527-37. PMID: 26555315; PMCID: PMC4860182 [Available on 05/01/17].
      15. Steinmetz D, Ramos E, Campbell SN, Morales T, Rissman R. Reproductive Stage and Modulation of Stress-Induced Tau Phosphorylation in Female Rats. J Neuroendocrinol. 2015 Nov; 27(11):827-34. PMID: 26510116; PMCID: PMC4625411 [Available on 11/01/16].
      16. Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman R. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. PMID: 26441570; PMCID: PMC4568340.
      17. Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman R, Raman R, Aisen PS. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 85(16):1383-91. PMID: 26362286; PMCID: PMC4626244.
      18. Oh ES, Marano CM, Leoutsakos JM, Lee RW, Rissman R, Smith GS, Craft S, Lyketsos CG. Oral glucose tolerance testing to modulate plasma amyloid levels: A novel biomarker. Alzheimers Dement (Amst). 2015 Sep; 1(3):311-315. PMID: 26413562.
        View in: PubMed
      19. Clark LR, Nation DA, Wierenga CE, Bangen KJ, Dev SI, Shin DD, Delano-Wood L, Liu TT, Rissman R, Bondi MW. Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old. Alzheimers Res Ther. 2015 Jan 21; 7(1):3. PMID: 27391477; PMCID: PMC4942967.
      20. Hanson AJ, Bayer JL, Baker LD, Cholerton B, VanFossen B, Trittschuh E, Rissman R, Donohue MC, Moghadam SH, Plymate SR, Craft S. Differential Effects of Meal Challenges on Cognition, Metabolism, and Biomarkers for Apolipoprotein E ?4 Carriers and Adults with Mild Cognitive Impairment. J Alzheimers Dis. 2015; 48(1):205-18. PMID: 26401941.
        View in: PubMed
      21. Campbell SN, Zhang C, Monte L, Roe AD, Rice KC, Taché Y, Masliah E, Rissman R. Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. J Alzheimers Dis. 2015; 43(3):967-76. PMID: 25125464; PMCID: PMC4258165.
      22. Zhang C, Rissman R, Feng J. Characterization of ATP alternations in an Alzheimer's disease transgenic mouse model. J Alzheimers Dis. 2015; 44(2):375-8. PMID: 25261448; PMCID: PMC4305018.
      23. Campbell SN, Zhang C, Roe AD, Lee N, Lao KU, Monte L, Donohue MC, Rissman R. Impact of CRFR1 Ablation on Amyloid-ß Production and Accumulation in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015; 45(4):1175-84. PMID: 25697705; PMCID: PMC4459491.
      24. Zhang C, Kuo CC, Moghadam SH, Monte L, Rice KC, Rissman R. Corticotropin-Releasing Factor Receptor-1 Antagonism Reduces Oxidative Damage in an Alzheimer’s Disease Transgenic Mouse Model. J Alzheimers Dis. 2015; 45(2):639-50. PMID: 25649650; PMCID: PMC4486520.
      25. Donohue MC, Moghadam SH, Roe AD, Sun CK, Edland SD, Thomas RG, Petersen RC, Sano M, Galasko D, Aisen PS, Rissman R. Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement. 2015 Sep; 11(9):1069-79. PMID: 25301682; PMCID: PMC4387108.
      26. O'Bryant SE, Gupta V, Henriksen K, Edwards M, Jeromin A, Lista S, Bazenet C, Soares H, Lovestone S, Hampel H, Montine T, Blennow K, Foroud T, Carrillo M, Graff-Radford N, Laske C, Breteler M, Shaw L, Trojanowski JQ, Schupf N, Rissman R, Fagan AM, Oberoi P, Umek R, Weiner MW, Grammas P, Posner H, Martins R. Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimers Dement. 2015 May; 11(5):549-60. PMID: 25282381; PMCID: PMC4414664.
      27. Zhang C, Nestorova G, Rissman R, Feng J. Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis. Electrophoresis. 2013 Aug; 34(15):2268-74. PMID: 23712533; PMCID: PMC3789118.
      28. Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, Lachno DR, Lleó A, Lewczuk P, Molinuevo JL, Parchi P, Regeniter A, Rissman RA, Rissman R, Rosenmann H, Sancesario G, Schröder J, Shaw LM, Teunissen CE, Trojanowski JQ, Vanderstichele H, Vandijck M, Verbeek MM, Zetterberg H, Blennow K. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimers Dement. 2013 May; 9(3):251-61. PMID: 23622690; PMCID: PMC3707386.
      29. Nation DA, Wierenga CE, Clark LR, Dev SI, Stricker NH, Jak AJ, Salmon DP, Delano-Wood L, Bangen KJ, Rissman R, Liu TT, Bondi MW. Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2013; 36(4):689-98. PMID: 23666173; PMCID: PMC4089500.
      30. Wierenga CE, Clark LR, Dev SI, Shin DD, Jurick SM, Rissman R, Liu TT, Bondi MW. Interaction of age and APOE genotype on cerebral blood flow at rest. J Alzheimers Dis. 2013; 34(4):921-35. PMID: 23302659; PMCID: PMC4124882.
      31. Rissman R, Staup MA, Lee AR, Justice NJ, Rice KC, Vale W, Sawchenko PE. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6277-82. PMID: 22451915; PMCID: PMC3341026.
      32. Rissman R, Trojanowski JQ, Shaw LM, Aisen PS. Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease. J Neural Transm (Vienna). 2012 Jul; 119(7):843-50. PMID: 22354745; PMCID: PMC4305447.
      33. Roe AD, Staup MA, Serrats J, Sawchenko PE, Rissman R. Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci. 2011 Aug; 34(3):448-56. PMID: 21722209; PMCID: PMC3148267.
      34. Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman R, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement. 2011 Jul; 7(4):386-395.e6. PMID: 21784349; PMCID: PMC3710290.
      35. Rissman R, Mobley WC. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22. PMID: 21388375; PMCID: PMC3127285.
      36. Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman R, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R. Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science. 2009 Jul 17; 325(5938):328-32. PMID: 19541956; PMCID: PMC2865899.
      37. Rissman R. Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability? J Alzheimers Dis. 2009; 18(2):453-7. PMID: 19584431; PMCID: PMC2906152.
      38. Rissman R, De Blas AL, Armstrong DM. GABA(A) receptors in aging and Alzheimer's disease. J Neurochem. 2007 Nov; 103(4):1285-92. PMID: 17714455.
        View in: PubMed
      39. Rissman R, Lee KF, Vale W, Sawchenko PE. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007 Jun 13; 27(24):6552-62. PMID: 17567816.
        View in: PubMed
      40. Rissman R, Nocera R, Fuller LM, Kordower JH, Armstrong DM. Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus. Brain Res. 2006 Feb 16; 1073-1074:120-30. PMID: 16430870.
        View in: PubMed
      41. Rissman R, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. PMID: 15232619; PMCID: PMC437967.
      42. Armstrong DM, Sheffield R, Mishizen-Eberz AJ, Carter TL, Rissman R, Mizukami K, Ikonomovic MD. Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease. Cell Mol Neurobiol. 2003 Oct; 23(4-5):491-505. PMID: 14514010.
        View in: PubMed
      43. Rohn TT, Rissman R, Davis MC, Kim YE, Cotman CW, Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. PMID: 12505426.
        View in: PubMed