Robert Rissman

Title(s)Associate Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel Systemic Delivery of Peptide-Mediated Anti-Sense Oligonucleotides for Dementia with Lewy Bodies
    NIH RF1AG072053May 15, 2021 - Apr 30, 2024
    Role: Principal Investigator
    Identifying Molecular Signatures associated with Alzheimer's Disease in the Retina
    NIH R21AG070595Sep 11, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Health and Aging Brain among Latino Elders (HABLE-AT(N)) Study
    NIH R01AG058533Aug 1, 2020 - Apr 30, 2025
    Role: Co-Principal Investigator
    Novel Antagonists of the N-terminal Domain of the CRF Receptor Type 1 for Alzheimer's Disease
    NIH/NIA R01AG065385Jan 15, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Novel Antagonists of the N-terminal Domain of the CRF Receptor Type 1 for Alzheimer's Disease
    NIH RF1AG065385Jan 15, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Neuronal exosomes to identify biomarkers and pathology of deployment-related TBI
    NIH I01BX004312Oct 1, 2018 - Sep 30, 2022
    Role: Co-Principal Investigator
    Amyloid Burden among Mexican Americans
    NIH R56AG058533Sep 30, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    A Blood Test for Screening Into Alzheimer's Prevention Trials
    NIH R01AG058252Sep 15, 2017 - Jun 30, 2022
    Role: Co-Principal Investigator
    Proteomic characterization of exosomes from AD patients
    NIH R56AG057459Sep 15, 2017 - Aug 31, 2019
    Role: Co-Principal Investigator
    Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
    NIH R56AG057469Sep 15, 2017 - Aug 31, 2019
    Role: Principal Investigator
    A Proinflammatory Endophenotype to Predict NSAID Treatment Response Alzheimer's Disease Clinical Trials
    NIH R01AG051848Sep 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Pathogenicity of neuronally-derived tau in exosomes
    NIH R21AG051839Sep 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    Validation Studies of CRF Receptor 1 as a Target for AD
    NIH I01BX003040Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Systems biology of HIV, methamphetamine and antiretrovirals interactions
    NIH R01DA041750May 1, 2016 - Apr 30, 2021
    Role: Co-Principal Investigator
    Polytherapy for AD: Combining Gamma-secretase Modulation and CRFR1 Antagonism
    NIH R21AG047484Sep 1, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    NIH R01AG032755Aug 15, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Role of Intracellular ABeta in Tau Pathology
    NIH F32AG023433Jan 1, 2004 - Dec 31, 2004
    Role: Principal Investigator
    a-Synuclein vulnerability mechanisms and therapeutics in Alzheimer's Disease
    NIH R01AG018440Sep 1, 2001 - May 31, 2022
    Role: Co-Principal Investigator
    Alzheimer's Disease Cooperative Study
    NIH U19AG010483Jul 1, 1997 - Feb 28, 2021
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes. Genome Med. 2021 Sep 01; 13(1):141. Sun Y, Zhu J, Zhou D, Canchi S, Wu C, Cox NJ, Rissman RA, Gamazon ER, Wu L. PMID: 34470669.
      View in: PubMed   Mentions:    Fields:    
    2. Unbalanced regulation of a7 nAChRs by Ly6h and NACHO contributes to neurotoxicity in Alzheimer's disease. J Neurosci. 2021 Aug 26. Wu M, Liu CZ, Barrall EA, Rissman RA, Joiner WJ. PMID: 34446574.
      View in: PubMed   Mentions:    Fields:    
    3. Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial. Alzheimers Dement (Amst). 2021; 13(1):e12199. Ngolab J, Donohue M, Belsha A, Salazar J, Cohen P, Jaiswal S, Tan V, Gessert D, Korouri S, Aggarwal NT, Alber J, Johnson K, Jicha G, van Dyck C, Lah J, Salloway S, Sperling RA, Aisen PS, Rafii MS, Rissman RA. PMID: 34430703.
      View in: PubMed   Mentions:
    4. Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study. Alzheimers Dement. 2021 Jul 26. O'Bryant S, Petersen M, Hall J, Johnson L, Yaffe K, Braskie M, Toga AW, Rissman RA, HABLE study team . PMID: 34310015.
      View in: PubMed   Mentions:    Fields:    
    5. The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics. Alzheimers Dement (Amst). 2021; 13(1):e12202. O'Bryant SE, Johnson LA, Barber RC, Braskie MN, Christian B, Hall JR, Hazra N, King K, Kothapalli D, Large S, Mason D, Matsiyevskiy E, McColl R, Nandy R, Palmer R, Petersen M, Philips N, Rissman RA, Shi Y, Toga AW, Vintimilla R, Vig R, Zhang F, Yaffe K, HABLE Study Team . PMID: 34189247.
      View in: PubMed   Mentions:
    6. A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research. Alzheimers Dement. 2021 May 31. O'Bryant SE, Zhang F, Petersen M, Hall JR, Johnson LA, Yaffe K, Mason D, Braskie M, Barber RA, Rissman RA, Mapstone M, Mielke MM, Toga AW, HABLE Study Team . PMID: 34057802.
      View in: PubMed   Mentions:    Fields:    
    7. Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega. 2021 May 25; 6(20):13033-13056. Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. PMID: 34056454.
      View in: PubMed   Mentions:
    8. Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease. Alzheimers Dement. 2021 May 02. Madrasi K, Das R, Mohmmadabdul H, Lin L, Hyman BT, Lauffenburger DA, Albers MW, Rissman RA, Burke JM, Apgar JF, Wille L, Gruenbaum L, Hua F. PMID: 33938131.
      View in: PubMed   Mentions:    Fields:    
    9. Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer's Disease. J Proteome Res. 2021 05 07; 20(5):2762-2771. Bamberger C, Pankow S, Martínez-Bartolomé S, Ma M, Diedrich J, Rissman RA, Yates JR. PMID: 33872013.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Preclinical validation of a potent ?-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 Apr 05; 218(4). Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. PMID: 33651103.
      View in: PubMed   Mentions: 2     Fields:    
    11. Plasma Levels of Neuron- and Astrocyte-Derived Exosomal Amyloid Beta1-42, Amyloid Beta1-40, and Phosphorylated Tau Levels in Schizophrenia Patients and Non-psychiatric Comparison Subjects: Relationships With Cognitive Functioning and Psychopathology. Front Psychiatry. 2020; 11:532624. Lee EE, Winston-Gray C, Barlow JW, Rissman RA, Jeste DV. PMID: 33762974.
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    12. Effects of innate immune receptor stimulation on extracellular a-synuclein uptake and degradation by brain resident cells. Exp Mol Med. 2021 Feb; 53(2):281-290. Kim C, Kwon S, Iba M, Spencer B, Rockenstein E, Mante M, Adame A, Shin SJ, Fields JA, Rissman RA, Lee SJ, Masliah E. PMID: 33594256.
      View in: PubMed   Mentions: 1     Fields:    
    13. Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2. Neurobiol Dis. 2021 05; 152:105277. Ngolab J, Canchi S, Rasool S, Elmaarouf A, Thomas K, Sarsoza F, Grundman J, Mante M, Florio J, Nandankar N, Korouri S, Zago W, Masliah E, Rissman RA. PMID: 33516874.
      View in: PubMed   Mentions: 1     Fields:    
    14. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021 01 20; 80(2):102-111. Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. PMID: 33367843.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials. J Alzheimers Dis. 2021; 81(2):557-568. O'Bryant SE, Zhang F, Petersen M, Johnson L, Hall J, Rissman RA. PMID: 33814447.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    16. Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease. J Prev Alzheimers Dis. 2021; 8(3):240-248. Kellar D, Lockhart SN, Aisen P, Raman R, Rissman RA, Brewer J, Craft S. PMID: 34101779.
      View in: PubMed   Mentions: 1     Fields:    
    17. Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease. Science. 2021 01 15; 371(6526). Nakamura T, Oh CK, Liao L, Zhang X, Lopez KM, Gibbs D, Deal AK, Scott HR, Spencer B, Masliah E, Rissman RA, Yates JR, Lipton SA. PMID: 33273062.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies. Sci Transl Med. 2020 10 14; 12(565). Kim C, Beilina A, Smith N, Li Y, Kim M, Kumaran R, Kaganovich A, Mamais A, Adame A, Iba M, Kwon S, Lee WJ, Shin SJ, Rissman RA, You S, Lee SJ, Singleton AB, Cookson MR, Masliah E. PMID: 33055242.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. The innate immunity protein IFITM3 modulates ?-secretase in Alzheimer's disease. Nature. 2020 10; 586(7831):735-740. Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. PMID: 32879487.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    20. Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA Neurol. 2020 09 01; 77(9):1099-1109. Craft S, Raman R, Chow TW, Rafii MS, Sun CK, Rissman RA, Donohue MC, Brewer JB, Jenkins C, Harless K, Gessert D, Aisen PS. PMID: 32568367.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    21. Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate a-synuclein pathology. Acta Neuropathol Commun. 2020 08 04; 8(1):123. Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, Masliah D, Adame A, Masliah E, Rissman RA. PMID: 32753049.
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    22. Reproductive status impact on tau phosphorylation induced by chronic stress. Neurobiol Stress. 2020 Nov; 13:100241. Muñoz-Mayorga D, Rissman RA, Morales T. PMID: 33344697.
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    23. A missense point mutation in nerve growth factor (NGFR100W) results in selective peripheral sensory neuropathy. Prog Neurobiol. 2020 11; 194:101886. Yang W, Sung K, Xu W, Rodriguez MJ, Wu AC, Santos SA, Fang S, Uber RK, Dong SX, Guillory BC, Orain X, Raus J, Jolivalt C, Calcutt N, Rissman RA, Ding J, Wu C. PMID: 32693191.
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    24. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and a-synuclein transgenic models. J Neuroinflammation. 2020 Jul 17; 17(1):214. Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. PMID: 32680537.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain. Psychiatry Res Neuroimaging. 2020 10 30; 304:111137. Deslauriers J, Toth M, Scadeng M, McKenna BS, Bussell R, Gresack J, Rissman R, Risbrough VB, Brown GG. PMID: 32731113.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    26. Diverse proteins aggregate in mild cognitive impairment and Alzheimer's disease brain. Alzheimers Res Ther. 2020 06 19; 12(1):75. Kepchia D, Huang L, Dargusch R, Rissman RA, Shokhirev MN, Fischer W, Schubert D. PMID: 32560738.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Transl Neurodegener. 2020 06 18; 9(1):26. Shen R, Zhao X, He L, Ding Y, Xu W, Lin S, Fang S, Yang W, Sung K, Spencer B, Rissman RA, Lei M, Ding J, Wu C. PMID: 32552912.
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    28. The Area Deprivation Index: A novel tool for harmonizable risk assessment in Alzheimer's disease research. Alzheimers Dement (N Y). 2020; 6(1):e12039. Zuelsdorff M, Larson JL, Hunt JFV, Kim AJ, Koscik RL, Buckingham WR, Gleason CE, Johnson SC, Asthana S, Rissman RA, Bendlin BB, Kind AJH. PMID: 32548238.
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    29. Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology. JAMA Netw Open. 2020 06 01; 3(6):e207559. Powell WR, Buckingham WR, Larson JL, Vilen L, Yu M, Salamat MS, Bendlin BB, Rissman RA, Kind AJH. PMID: 32525547.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 06; 19(6):1017-1034. Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. PMID: 32295833.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau. Brain Commun. 2020; 2(1):fcaa025. Digma LA, Madsen JR, Rissman RA, Jacobs DM, Brewer JB, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative . PMID: 32337508.
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    33. Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein ß in HIV-associated neurocognitive disorder. J Neuroinflammation. 2020 Apr 11; 17(1):112. Canchi S, Swinton MK, Rissman RA, Fields JA. PMID: 32276639.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume. JAMA Neurol. 2020 04 01; 77(4):451-460. Hunt JFV, Buckingham W, Kim AJ, Oh J, Vogt NM, Jonaitis EM, Hunt TK, Zuelsdorff M, Powell R, Norton D, Rissman RA, Asthana S, Okonkwo OC, Johnson SC, Kind AJH, Bendlin BB. PMID: 31904767.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    35. Role of Alterations in Protein Kinase p38? in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and a-Synuclein Transgenic Models. Front Neurosci. 2020; 14:286. Iba M, Kim C, Florio J, Mante M, Adame A, Rockenstein E, Kwon S, Rissman R, Masliah E. PMID: 32296304.
      View in: PubMed   Mentions:
    36. The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. J Alzheimers Dis. 2020; 73(4):1541-1554. Prikhodko O, Rynearson KD, Sekhon T, Mante MM, Nguyen PD, Rissman RA, Tanzi RE, Wagner SL. PMID: 31958080.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    37. The Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease (TRC-PAD) Project: An Overview. J Prev Alzheimers Dis. 2020; 7(4):208-212. Aisen PS, Sperling RA, Cummings J, Donohue MC, Langford O, Jimenez-Maggiora GA, Rissman RA, Rafii MS, Walter S, Clanton T, Raman R. PMID: 32920621.
      View in: PubMed   Mentions: 7     Fields:    
    38. Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. Neurol Ther. 2019 Dec; 8(Suppl 2):57-72. Ngolab J, Honma P, Rissman RA. PMID: 31833024.
      View in: PubMed   Mentions:
    39. miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients. Front Neurosci. 2019; 13:1208. Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM. PMID: 31849573.
      View in: PubMed   Mentions:
    40. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139. Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    41. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2019 Nov 01; 76(11):1330-1339. Schneider LS, Thomas RG, Hendrix S, Rissman RA, Brewer JB, Salmon DP, Oltersdorf T, Okuda T, Feldman HH, Alzheimer’s Disease Cooperative Study TCAD Study Group . PMID: 31282954.
      View in: PubMed   Mentions: 5     Fields:    
    42. High-Throughput Mass Spectrometry Assay for Quantifying ß-Amyloid 40 and 42 in Cerebrospinal Fluid. Clin Chem. 2019 12; 65(12):1572-1580. Weber DM, Tran D, Goldman SM, Taylor SW, Ginns EI, Lagier RJ, Rissman RA, Brewer JB, Clarke NJ. PMID: 31628138.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    43. Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity. Front Neurosci. 2019; 13:1005. Winston CN, Romero HK, Ellisman M, Nauss S, Julovich DA, Conger T, Hall JR, Campana W, O'Bryant SE, Nievergelt CM, Baker DG, Risbrough VB, Rissman RA. PMID: 31680797.
      View in: PubMed   Mentions:
    44. Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM. PMID: 31329216.
      View in: PubMed   Mentions: 23     Fields:    
    45. Effects of single and combined immunotherapy approach targeting amyloid ß protein and a-synuclein in a dementia with Lewy bodies-like model. Alzheimers Dement. 2019 09; 15(9):1133-1148. Mandler M, Rockenstein E, Overk C, Mante M, Florio J, Adame A, Kim C, Santic R, Schneeberger A, Mattner F, Schmidhuber S, Galabova G, Spencer B, Masliah E, Rissman RA. PMID: 31378574.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    46. Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease. Cell Rep. 2019 07 23; 28(4):1103-1116.e4. Canchi S, Raao B, Masliah D, Rosenthal SB, Sasik R, Fisch KM, De Jager PL, Bennett DA, Rissman RA. PMID: 31340147.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    47. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain. 2019 06 01; 142(6):1503-1527. Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA. PMID: 31039256.
      View in: PubMed   Mentions: 185     Fields:    Translation:Humans
    48. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathol Commun. 2019 05 17; 7(1):77. Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. PMID: 31101070.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    49. Systemic peptide mediated delivery of an siRNA targeting a-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease. Neurobiol Dis. 2019 07; 127:163-177. Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, El-Agnaf OMA, Kim C, Masliah E, Rissman RA. PMID: 30849508.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 06; 137(6):879-899. Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R. PMID: 30739198.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
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    106. Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis. Electrophoresis. 2013 Aug; 34(15):2268-74. Zhang C, Nestorova G, Rissman RA, Feng J. PMID: 23712533.
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    107. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimers Dement. 2013 May; 9(3):251-61. Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, Lachno DR, Lleó A, Lewczuk P, Molinuevo JL, Parchi P, Regeniter A, Rissman RA, Rissman R, Rosenmann H, Sancesario G, Schröder J, Shaw LM, Teunissen CE, Trojanowski JQ, Vanderstichele H, Vandijck M, Verbeek MM, Zetterberg H, Blennow K, Alzheimer's Association QC Program Work Group . PMID: 23622690.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansCells
    108. Interaction of age and APOE genotype on cerebral blood flow at rest. J Alzheimers Dis. 2013; 34(4):921-35. Wierenga CE, Clark LR, Dev SI, Shin DD, Jurick SM, Rissman RA, Liu TT, Bondi MW. PMID: 23302659.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    109. Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2013; 36(4):689-98. Nation DA, Wierenga CE, Clark LR, Dev SI, Stricker NH, Jak AJ, Salmon DP, Delano-Wood L, Bangen KJ, Rissman RA, Liu TT, Bondi MW. PMID: 23666173.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    110. Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition. J Cereb Blood Flow Metab. 2012 Aug; 32(8):1589-99. Wierenga CE, Dev SI, Shin DD, Clark LR, Bangen KJ, Jak AJ, Rissman RA, Liu TT, Salmon DP, Bondi MW. PMID: 22549621.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    111. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6277-82. Rissman RA, Staup MA, Lee AR, Justice NJ, Rice KC, Vale W, Sawchenko PE. PMID: 22451915.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    112. Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease. J Neural Transm (Vienna). 2012 Jul; 119(7):843-50. Rissman RA, Trojanowski JQ, Shaw LM, Aisen PS. PMID: 22354745.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    113. Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci. 2011 Aug; 34(3):448-56. Roe AD, Staup MA, Serrats J, Sawchenko PE, Rissman RA. PMID: 21722209.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    114. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement. 2011 Jul; 7(4):386-395.e6. Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. PMID: 21784349.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    115. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22. Rissman RA, Mobley WC. PMID: 21388375.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    116. Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science. 2009 Jul 17; 325(5938):328-32. Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R. PMID: 19541956.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansAnimalsCells
    117. Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability? J Alzheimers Dis. 2009; 18(2):453-7. Rissman RA. PMID: 19584431.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    118. GABA(A) receptors in aging and Alzheimer's disease. J Neurochem. 2007 Nov; 103(4):1285-92. Rissman RA, De Blas AL, Armstrong DM. PMID: 17714455.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    119. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007 Jun 13; 27(24):6552-62. Rissman RA, Lee KF, Vale W, Sawchenko PE. PMID: 17567816.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    120. Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus. Brain Res. 2006 Feb 16; 1073-1074:120-30. Rissman RA, Nocera R, Fuller LM, Kordower JH, Armstrong DM. PMID: 16430870.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    121. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. PMID: 15986225.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    122. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15751224.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    123. Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment. J Chem Neuroanat. 2004 Sep; 28(1-2):17-25. Rissman RA, Bennett DA, Armstrong DM. PMID: 15363487.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    124. Caspase-mediated degeneration in Alzheimer's disease. Am J Pathol. 2004 Aug; 165(2):353-5. Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15277211.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    125. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansAnimalsCells
    126. Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage. Exp Neurol. 2004 Jun; 187(2):299-309. Carter TL, Rissman RA, Mishizen-Eberz AJ, Wolfe BB, Hamilton RL, Gandy S, Armstrong DM. PMID: 15144856.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    127. Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology. Neurobiol Dis. 2004 Feb; 15(1):80-92. Mishizen-Eberz AJ, Rissman RA, Carter TL, Ikonomovic MD, Wolfe BB, Armstrong DM. PMID: 14751773.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    128. Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease. Cell Mol Neurobiol. 2003 Oct; 23(4-5):491-505. Armstrong DM, Sheffield R, Mishizen-Eberz AJ, Carter TL, Rissman RA, Mizukami K, Ikonomovic MD. PMID: 14514010.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    129. Biochemical analysis of GABA(A) receptor subunits alpha 1, alpha 5, beta 1, beta 2 in the hippocampus of patients with Alzheimer's disease neuropathology. Neuroscience. 2003; 120(3):695-704. Rissman RA, Mishizen-Eberz AJ, Carter TL, Wolfe BB, De Blas AL, Miralles CP, Ikonomovic MD, Armstrong DM. PMID: 12895510.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    130. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
      View in: PubMed   Mentions: 19     Fields:    
    131. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. PMID: 12505426.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    132. Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol. 1999 Dec 20; 415(3):285-312. Bittencourt JC, Vaughan J, Arias C, Rissman RA, Vale WW, Sawchenko PE. PMID: 10553117.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    133. The distribution of melanin-concentrating hormone in the monkey brain (Cebus apella). Brain Res. 1998 Aug 31; 804(1):140-3. Bittencourt JC, Frigo L, Rissman RA, Casatti CA, Nahon JL, Bauer JA. PMID: 9729342.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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