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Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation. Proc Natl Acad Sci U S A. 2024 Apr 09; 121(15):e2321338121.
Ma D, Ojha P, Yu AD, Araujo MS, Luo W, Keefer E, Díaz MM, Wu M, Joiner WJ, Abruzzi KC, Rosbash M. PMID: 38568969; PMCID: PMC11009632.
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AnimalsCells
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Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity. Acta Neuropathol Commun. 2023 10 17; 11(1):164.
Bennett CL, Dastidar S, Arnold FJ, McKinstry SU, Stockford C, Freibaum BD, Sopher BL, Wu M, Seidner G, Joiner W, Taylor JP, West RJH, La Spada AR. PMID: 37845749; PMCID: PMC10580588.
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PubMed Mentions:
4 Fields:
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HumansAnimalsCells
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Re-examining the role of the dorsal fan-shaped body in promoting sleep in Drosophila. Curr Biol. 2023 09 11; 33(17):3660-3668.e4.
De J, Wu M, Lambatan V, Hua Y, Joiner WJ. PMID: 37552985; PMCID: PMC10573663.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Inputs to the Sleep Homeostat Originate Outside the Brain. J Neurosci. 2022 Jul 20; 42(29):5695-5704.
Satterfield LK, De J, Wu M, Qiu T, Joiner WJ. PMID: 35680412; PMCID: PMC9302467.
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PubMed Mentions:
8 Fields:
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Unbalanced Regulation of α7 nAChRs by Ly6h and NACHO Contributes to Neurotoxicity in Alzheimer's Disease. J Neurosci. 2021 10 13; 41(41):8461-8474.
Wu M, Liu CZ, Barrall EA, Rissman RA, Joiner WJ. PMID: 34446574; PMCID: PMC8513707.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Neuroscience: Sleep Fragmentation Impairs Memory Formation. Curr Biol. 2019 11 18; 29(22):R1181-R1184.
Joiner WJ. PMID: 31743673.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel. Neuron. 2019 12 04; 104(5):947-959.e5.
Ng R, Salem SS, Wu ST, Wu M, Lin HH, Shepherd AK, Joiner WJ, Wang JW, Su CY. PMID: 31629603; PMCID: PMC6895426.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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The Neurobiological Basis of Sleep and Sleep Disorders. Physiology (Bethesda). 2018 09 01; 33(5):317-327.
Joiner WJ. PMID: 30109824; PMCID: PMC6230548.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Unraveling the Evolutionary Determinants of Sleep. Curr Biol. 2016 10 24; 26(20):R1073-R1087.
Joiner WJ. PMID: 27780049; PMCID: PMC5120870.
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PubMed Mentions:
88 Fields:
Translation:
Animals
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Using Drosophila as an integrated model to study mild repetitive traumatic brain injury. Sci Rep. 2016 05 04; 6:25252.
Barekat A, Gonzalez A, Mauntz RE, Kotzebue RW, Molina B, El-Mecharrafie N, Conner CJ, Garza S, Melkani GC, Joiner WJ, Lipinski MM, Finley KD, Ratliff EP. PMID: 27143646; PMCID: PMC4855207.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms. Neuropharmacology. 2016 08; 107:262-270.
Landgraf D, Joiner WJ, McCarthy MJ, Kiessling S, Barandas R, Young JW, Cermakian N, Welsh DK. PMID: 27033596.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors. PLoS One. 2016; 11(2):e0148215.
Wu M, Liu CZ, Joiner WJ. PMID: 26828958; PMCID: PMC4735452.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. Nat Commun. 2016 Jan 27; 7:10512.
Robinson JE, Paluch J, Dickman DK, Joiner WJ. PMID: 26813350; PMCID: PMC4737855.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Identification of Neurons with a Privileged Role in Sleep Homeostasis in Drosophila melanogaster. Curr Biol. 2015 Nov 16; 25(22):2928-38.
Seidner G, Robinson JE, Wu M, Worden K, Masek P, Roberts SW, Keene AC, Joiner WJ. PMID: 26526372; PMCID: PMC4654679.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. J Biol Chem. 2015 Oct 02; 290(40):24509-18.
Wu M, Puddifoot CA, Taylor P, Joiner WJ. PMID: 26276394; PMCID: PMC4591831.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors. PLoS One. 2015; 10(7):e0132768.
Ratliff EP, Mauntz RE, Kotzebue RW, Gonzalez A, Achal M, Barekat A, Finley KA, Sparhawk JM, Robinson JE, Herr DR, Harris GL, Joiner WJ, Finley KD. PMID: 26182057; PMCID: PMC4504520.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. PLoS Genet. 2015 Jul; 11(7):e1005344.
Zhang S, Ross KD, Seidner GA, Gorman MR, Poon TH, Wang X, Keithley EM, Lee PN, Martindale MQ, Joiner WJ, Hamilton BA. PMID: 26131556; PMCID: PMC4488434.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Neurodegeneration: paying it off with sleep. Curr Biol. 2015 Mar 16; 25(6):R234-R236.
Keene AC, Joiner WJ. PMID: 25784043; PMCID: PMC4381801.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling. J Neurosci. 2015 Feb 25; 35(8):3420-30.
Puddifoot CA, Wu M, Sung RJ, Joiner WJ. PMID: 25716842; PMCID: PMC4339353.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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SLEEPLESS is a bifunctional regulator of excitability and cholinergic synaptic transmission. Curr Biol. 2014 Mar 17; 24(6):621-9.
Wu M, Robinson JE, Joiner WJ. PMID: 24613312; PMCID: PMC4059605.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab. 2014 Feb; 3(1):42-54.
Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG. PMID: 24567903; PMCID: PMC3929909.
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PubMed Mentions:
54 Fields:
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Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness. PLoS Genet. 2013; 9(9):e1003605.
Joiner WJ, Friedman EB, Hung HT, Koh K, Sowcik M, Sehgal A, Kelz MB. PMID: 24039590; PMCID: PMC3764144.
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PubMed Mentions:
42 Fields:
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HumansAnimalsCells
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Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels. J Neurosci. 2011 Aug 03; 31(31):11387-95.
Dean T, Xu R, Joiner W, Sehgal A, Hoshi T. PMID: 21813698; PMCID: PMC3183472.
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PubMed Mentions:
18 Fields:
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HumansAnimalsCells
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A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One. 2010 Jul 30; 5(7):e11903.
Friedman EB, Sun Y, Moore JT, Hung HT, Meng QC, Perera P, Joiner WJ, Thomas SA, Eckenhoff RG, Sehgal A, Kelz MB. PMID: 20689589; PMCID: PMC2912772.
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PubMed Mentions:
104 Fields:
Translation:
Animals
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SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nat Neurosci. 2010 Jan; 13(1):69-75.
Wu MN, Joiner WJ, Dean T, Yue Z, Smith CJ, Chen D, Hoshi T, Sehgal A, Koh K. PMID: 20010822; PMCID: PMC2842941.
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PubMed Mentions:
64 Fields:
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HumansAnimalsCells
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Identification of SLEEPLESS, a sleep-promoting factor. Science. 2008 Jul 18; 321(5887):372-6.
Koh K, Joiner WJ, Wu MN, Yue Z, Smith CJ, Sehgal A. PMID: 18635795; PMCID: PMC2771549.
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PubMed Mentions:
178 Fields:
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AnimalsCells
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A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep. 2008 Apr; 31(4):465-72.
Wu MN, Koh K, Yue Z, Joiner WJ, Sehgal A. PMID: 18457233; PMCID: PMC2279757.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsPHPublic Health
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Molecular analysis of sleep: wake cycles in Drosophila. Cold Spring Harb Symp Quant Biol. 2007; 72:557-64.
Sehgal A, Joiner W, Crocker A, Koh K, Sathyanarayanan S, Fang Y, Wu M, Williams JA, Zheng X. PMID: 18419315.
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PubMed Mentions:
15 Fields:
Translation:
Animals
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Sleep in Drosophila is regulated by adult mushroom bodies. Nature. 2006 Jun 08; 441(7094):757-60.
Joiner WJ, Crocker A, White BH, Sehgal A. PMID: 16760980.
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PubMed Mentions:
238 Fields:
Translation:
Animals
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A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol. 2006 Jun 06; 16(11):1051-62.
Yuan Q, Joiner WJ, Sehgal A. PMID: 16753559.
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PubMed Mentions:
154 Fields:
Translation:
Animals
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The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior. J Biol Chem. 2004 Dec 10; 279(50):52324-30.
Zhang Y, Joiner WJ, Bhattacharjee A, Rassendren F, Magoski NS, Kaczmarek LK. PMID: 15375169.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. J Neurosci. 2003 Dec 17; 23(37):11681-91.
Bhattacharjee A, Joiner WJ, Wu M, Yang Y, Sigworth FJ, Kaczmarek LK. PMID: 14684870; PMCID: PMC6740956.
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PubMed Mentions:
119 Fields:
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HumansAnimalsCells
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The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7366-71.
Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A. PMID: 12773623; PMCID: PMC165881.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon. Am J Physiol Gastrointest Liver Physiol. 2003 Jul; 285(1):G185-96.
Joiner WJ, Basavappa S, Vidyasagar S, Nehrke K, Krishnan S, Binder HJ, Boulpaep EL, Rajendran VM. PMID: 12606302.
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PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
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Targeted attenuation of electrical activity in Drosophila using a genetically modified K(+) channel. Neuron. 2001 Sep 13; 31(5):699-711.
White BH, Osterwalder TP, Yoon KS, Joiner WJ, Whim MD, Kaczmarek LK, Keshishian H. PMID: 11567611.
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PubMed Mentions:
58 Fields:
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AnimalsCells
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Calmodulin regulates assembly and trafficking of SK4/IK1 Ca2+-activated K+ channels. J Biol Chem. 2001 Oct 12; 276(41):37980-5.
Joiner WJ, Khanna R, Schlichter LC, Kaczmarek LK. PMID: 11495911.
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PubMed Mentions:
51 Fields:
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HumansAnimalsCells
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hSK4/hIK1, a calmodulin-binding KCa channel in human T lymphocytes. Roles in proliferation and volume regulation. J Biol Chem. 1999 May 21; 274(21):14838-49.
Khanna R, Chang MC, Joiner WJ, Kaczmarek LK, Schlichter LC. PMID: 10329683.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nat Neurosci. 1998 Oct; 1(6):462-9.
Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. PMID: 10196543.
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PubMed Mentions:
81 Fields:
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AnimalsCells
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hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):11013-8.
Joiner WJ, Wang LY, Tang MD, Kaczmarek LK. PMID: 9380751; PMCID: PMC23566.
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PubMed Mentions:
131 Fields:
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HumansAnimalsCells
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A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature. 1995 Aug 24; 376(6542):690-5.
Ketchum KA, Joiner WJ, Sellers AJ, Kaczmarek LK, Goldstein SA. PMID: 7651518.
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PubMed Mentions:
124 Fields:
Translation:
AnimalsCells
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A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels. Neuron. 1994 Feb; 12(2):301-15.
McCormack K, Joiner WJ, Heinemann SH. PMID: 8110460.
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PubMed Mentions:
69 Fields:
Translation:
AnimalsCells