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Wendy Campana

Title(s)Professor, Anesthesiology
SchoolHealth Sciences
Phone858-822-3767
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying novel proteins in injured nerves that promote functional regeneration
    VA I01RX002484Nov 1, 2018 - Oct 31, 2022
    Role: Principal Investigator
    Schwann Cell NMDA Receptor in PNS Injury
    NIH/NINDS R01NS097590Feb 1, 2017 - Jan 31, 2021
    Role: Co-Principal Investigator
    LRP-1 is a multifunctional regulator during peripheral nerve injury and pain.
    NIH/NINDS R01NS057456Jan 15, 2008 - Dec 31, 2013
    Role: Principal Investigator
    Epo-dependent JAK2 Signaling in Painful Neuropathy
    NIH/NINDS R01NS041983Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Brifault C, Kwon H, Campana WM, Gonias SL. LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia. 2019 Jun; 67(6):1210-1224. PMID: 30746765.
      View in: PubMed
    2. Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E. PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. J Cell Sci. 2018 07 26; 131(14). PMID: 29930084.
      View in: PubMed
    3. Poplawski G, Ishikawa T, Brifault C, Lee-Kubli C, Regestam R, Henry KW, Shiga Y, Kwon H, Ohtori S, Gonias SL, Campana WM. Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. Glia. 2018 08; 66(8):1577-1590. PMID: 29520865.
      View in: PubMed
    4. Shahriari D, Shibayama M, Lynam DA, Wolf KJ, Kubota G, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. Peripheral nerve growth within a hydrogel microchannel scaffold supported by a kink-resistant conduit. J Biomed Mater Res A. 2017 Dec; 105(12):3392-3399. PMID: 28804998.
      View in: PubMed
    5. Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL. Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017 09 14; 130(11):1364-1374. PMID: 28684538.
      View in: PubMed
    6. Shahriari D, Koffler JY, Tuszynski MH, Campana WM, Sakamoto JS. Hierarchically Ordered Porous and High-Volume Polycaprolactone Microchannel Scaffolds Enhanced Axon Growth in Transected Spinal Cords. Tissue Eng Part A. 2017 05; 23(9-10):415-425. PMID: 28107810.
      View in: PubMed
    7. Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL. Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells. FASEB J. 2017 04; 31(4):1744-1755. PMID: 28073836.
      View in: PubMed
    8. Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM. Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells. Neuroreport. 2016 12 14; 27(18):1305-1311. PMID: 27824728.
      View in: PubMed
    9. Gao M, Lu P, Lynam D, Bednark B, Campana WM, Sakamoto J, Tuszynski M. BDNF gene delivery within and beyond templated agarose multi-channel guidance scaffolds enhances peripheral nerve regeneration. J Neural Eng. 2016 12; 13(6):066011. PMID: 27762235.
      View in: PubMed
    10. Lee-Kubli CA, Ingves M, Henry KW, Shiao R, Collyer E, Tuszynski MH, Campana WM. Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury. Exp Neurol. 2016 Apr; 278:91-104. PMID: 26808661.
      View in: PubMed
    11. Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL. The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. J Cell Sci. 2015 Sep 15; 128(18):3478-88. PMID: 26272917.
      View in: PubMed
    12. Gonias SL, Campana WM. LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system. Am J Pathol. 2014 Jan; 184(1):18-27. PMID: 24128688.
      View in: PubMed
    13. Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM. Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons. PLoS One. 2013; 8(9):e75497. PMID: 24086544.
      View in: PubMed
    14. Yoon C, Van Niekerk EA, Henry K, Ishikawa T, Orita S, Tuszynski MH, Campana WM. Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. J Biol Chem. 2013 Sep 13; 288(37):26557-68. PMID: 23867460.
      View in: PubMed
    15. Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM. Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci. 2013 Mar 27; 33(13):5590-602. PMID: 23536074.
      View in: PubMed
    16. Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM. The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci. 2011 Sep 21; 31(38):13376-85. PMID: 21940431.
      View in: PubMed
    17. Shi Y, Yamauchi T, Gaultier A, Takimoto S, Campana WM, Gonias SL. Regulation of cytokine expression by Schwann cells in response to a2-macroglobulin binding to LRP1. J Neurosci Res. 2011 Apr; 89(4):544-51. PMID: 21290408.
      View in: PubMed
    18. Gorovoy M, Gaultier A, Campana WM, Firestein GS, Gonias SL. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol. 2010 Oct; 88(4):769-78. PMID: 20610799.
      View in: PubMed
    19. Ghezzi P, Bernaudin M, Bernaudinb M, Bianchi R, Bianchic R, Blomgren K, Brines M, Campana W, Cavaletti G, Cerami A, Chopp M, Coleman T, Digicaylioglu M, Ehrenreich H, Erbayraktar S, Erbayraktar Z, Gassmann M, Genc S, Gokmen N, Grasso G, Juul S, Lipton SA, Hand CC, Latini R, Lauria G, Leist M, Newton SS, Petit E, Probert L, Sfacteria A, Siren AL, Talan M, Thiemermann C, Westenbrink D, Yaqoob M, Zhu C. Erythropoietin: not just about erythropoiesis. Lancet. 2010 Jun 19; 375(9732):2142. PMID: 20609950.
      View in: PubMed
    20. Mantuano E, Jo M, Gonias SL, Campana WM. Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. J Biol Chem. 2010 May 07; 285(19):14259-66. PMID: 20197276.
      View in: PubMed
    21. Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana WM. Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface. Glia. 2010 Mar; 58(4):399-409. PMID: 19705458.
      View in: PubMed
    22. Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL. Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal. 2009 Apr 28; 2(68):ra18. PMID: 19401592.
      View in: PubMed
    23. Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana WM, Gonias SL. Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci. 2009 Apr 15; 122(Pt 8):1155-62. PMID: 19299462.
      View in: PubMed
    24. Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM. Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat. J Neurosci Res. 2009 Mar; 87(4):948-55. PMID: 18855936.
      View in: PubMed
    25. Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci. 2008 Nov 05; 28(45):11571-82. PMID: 18987193.
      View in: PubMed
    26. Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL. Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem. 2008 Jul 18; 283(29):19904-11. PMID: 18499670.
      View in: PubMed
    27. Gaultier A, Arandjelovic S, Niessen S, Overton CD, Linton MF, Fazio S, Campana WM, Cravatt BF, Gonias SL. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood. 2008 Jun 01; 111(11):5316-25. PMID: 18369152.
      View in: PubMed
    28. Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou GP, Dolkas J, Myers RR, Gonias SL, Campana WM. A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. J Clin Invest. 2008 Jan; 118(1):161-72. PMID: 18060043.
      View in: PubMed
    29. Montel V, Gaultier A, Lester RD, Campana WM, Gonias SL. The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer Res. 2007 Oct 15; 67(20):9817-24. PMID: 17942912.
      View in: PubMed
    30. Arandjelovic S, Dragojlovic N, Li X, Myers RR, Campana WM, Gonias SL. A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury. J Neurochem. 2007 Oct; 103(2):694-705. PMID: 17725582.
      View in: PubMed
    31. Campana WM. Schwann cells: activated peripheral glia and their role in neuropathic pain. Brain Behav Immun. 2007 Jul; 21(5):522-7. PMID: 17321718.
      View in: PubMed
    32. Campana WM, Li X, Dragojlovic N, Janes J, Gaultier A, Gonias SL. The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury. J Neurosci. 2006 Oct 25; 26(43):11197-207. PMID: 17065459.
      View in: PubMed
    33. Takahashi N, Kikuchi S, Shubayev VI, Campana WM, Myers RR. TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica. Spine (Phila Pa 1976). 2006 Mar 01; 31(5):523-9. PMID: 16508545.
      View in: PubMed
    34. Campana WM, Li X, Shubayev VI, Angert M, Cai K, Myers RR. Erythropoietin reduces Schwann cell TNF-alpha, Wallerian degeneration and pain-related behaviors after peripheral nerve injury. Eur J Neurosci. 2006 Feb; 23(3):617-26. PMID: 16487143.
      View in: PubMed
    35. Myers RR, Campana WM, Shubayev VI. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov Today. 2006 Jan; 11(1-2):8-20. PMID: 16478686.
      View in: PubMed
    36. Shubayev VI, Angert M, Dolkas J, Campana WM, Palenscar K, Myers RR. TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci. 2006 Mar; 31(3):407-15. PMID: 16297636.
      View in: PubMed
    37. Lester RD, Jo M, Campana WM, Gonias SL. Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J Biol Chem. 2005 Nov 25; 280(47):39273-7. PMID: 16207704.
      View in: PubMed
    38. Bouaziz H, Iohom G, Estèbe JP, Campana WM, Myers RR. Effects of levobupivacaine and ropivacaine on rat sciatic nerve blood flow. Br J Anaesth. 2005 Nov; 95(5):696-700. PMID: 16183680.
      View in: PubMed
    39. Li X, Gonias SL, Campana WM. Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury. Glia. 2005 Sep; 51(4):254-65. PMID: 15812815.
      View in: PubMed
    40. Sekiguchi Y, Kikuchi S, Myers RR, Campana WM. ISSLS prize winner: Erythropoietin inhibits spinal neuronal apoptosis and pain following nerve root crush. Spine (Phila Pa 1976). 2003 Dec 01; 28(23):2577-84. PMID: 14652474.
      View in: PubMed
    41. Myers RR, Sekiguchi Y, Kikuchi S, Scott B, Medicherla S, Protter A, Campana WM. Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp Neurol. 2003 Dec; 184(2):606-14. PMID: 14769353.
      View in: PubMed
    42. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. PMID: 12950462.
      View in: PubMed
    43. Campana WM, Myers RR. Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injury. Eur J Neurosci. 2003 Sep; 18(6):1497-506. PMID: 14511329.
      View in: PubMed
    44. Campana WM, Myers RR, Rearden A. Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. Glia. 2003 Feb; 41(3):213-23. PMID: 12528177.
      View in: PubMed
    45. Campana WM, Myers RR. Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury. FASEB J. 2001 Aug; 15(10):1804-6. PMID: 11481236.
      View in: PubMed
    46. Rende M, Brizi E, Donato R, Provenzano C, Bruno R, Mizisin AP, Garrett RS, Calcutt NA, Campana WM, O'Brien JS. Prosaposin is immunolocalized to muscle and prosaptides promote myoblast fusion and attenuate loss of muscle mass after nerve injury. Muscle Nerve. 2001 Jun; 24(6):799-808. PMID: 11360264.
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    47. Hiraiwa M, Campana WM, Wang CY, Otero DA, O'Brien JS. A retro-inverso Prosaptide D5 promotes a myelination process in developing rats. Brain Res Dev Brain Res. 2001 May 31; 128(1):73-6. PMID: 11356264.
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    48. Misasi R, Sorice M, Di Marzio L, Campana WM, Molinari S, Cifone MG, Pavan A, Pontieri GM, O'Brien JS. Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase. FASEB J. 2001 Feb; 15(2):467-74. PMID: 11156962.
      View in: PubMed
    49. Campana WM, Mohiuddin L, Misasi R, O'Brien JS, Calcutt NA. Prosaposin-derived peptides enhanced sprouting of sensory neurons in vitro and induced sprouting at motor endplates in vivo. J Peripher Nerv Syst. 2000 Sep; 5(3):126-30. PMID: 11442168.
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    50. Cai F, Campana WM, Tomlinson DR, Fernyhough P. Transforming growth factor-beta1 and glial growth factor 2 reduce neurotrophin-3 mRNA expression in cultured Schwann cells via a cAMP-dependent pathway. Brain Res Mol Brain Res. 1999 Aug 25; 71(2):256-64. PMID: 10521580.
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    51. Campana WM, Darin SJ, O'Brien JS. Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-I- and prosaptide-induced survival in Schwann cells. J Neurosci Res. 1999 Aug 01; 57(3):332-41. PMID: 10412024.
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    52. Calcutt NA, Campana WM, Eskeland NL, Mohiuddin L, Dines KC, Mizisin AP, O'Brien JS. Prosaposin gene expression and the efficacy of a prosaposin-derived peptide in preventing structural and functional disorders of peripheral nerve in diabetic rats. J Neuropathol Exp Neurol. 1999 Jun; 58(6):628-36. PMID: 10374753.
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    53. Hiraiwa M, Campana WM, Mizisin AP, Mohiuddin L, O'Brien JS. Prosaposin: a myelinotrophic protein that promotes expression of myelin constituents and is secreted after nerve injury. Glia. 1999 Jun; 26(4):353-60. PMID: 10383054.
      View in: PubMed
    54. Campana WM, O'Brien JS, Hiraiwa M, Patton S. Secretion of prosaposin, a multifunctional protein, by breast cancer cells. Biochim Biophys Acta. 1999 May 24; 1427(3):392-400. PMID: 10350655.
      View in: PubMed
    55. Shelton GD, Calcutt NA, Garrett RS, Gu D, Sarvetnick N, Campana WM, Powell HC. Necrotizing myopathy induced by overexpression of interferon-gamma in transgenic mice. Muscle Nerve. 1999 Feb; 22(2):156-65. PMID: 10024128.
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    56. Misasi R, Sorice M, Garofalo T, Griggi T, Campana WM, Giammatteo M, Pavan A, Hiraiwa M, Pontieri GM, O'Brien JS. Colocalization and complex formation between prosaposin and monosialoganglioside GM3 in neural cells. J Neurochem. 1998 Dec; 71(6):2313-21. PMID: 9832129.
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    57. Campana WM, Eskeland N, Calcutt NA, Misasi R, Myers RR, O'Brien JS. Prosaptide prevents paclitaxel neurotoxicity. Neurotoxicology. 1998 Apr; 19(2):237-44. PMID: 9553960.
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    58. Campana WM, Hiraiwa M, O'Brien JS. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998 Mar; 12(3):307-14. PMID: 9506474.
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    59. Campana WM, Misasi R, O'Brien JS. Identification of a neurotrophic sequence in erythropoietin. Int J Mol Med. 1998 Jan; 1(1):235-41. PMID: 9852225.
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    60. Hiraiwa M, Campana WM, Martin BM, O'Brien JS. Prosaposin receptor: evidence for a G-protein-associated receptor. Biochem Biophys Res Commun. 1997 Nov 17; 240(2):415-8. PMID: 9388493.
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    61. Hiraiwa M, Taylor EM, Campana WM, Darin SJ, O'Brien JS. Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4778-81. PMID: 9114068.
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    62. Campana WM, Hiraiwa M, Addison KC, O'Brien JS. Induction of MAPK phosphorylation by prosaposin and prosaptide in PC12 cells. Biochem Biophys Res Commun. 1996 Dec 24; 229(3):706-12. PMID: 8954961.
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    63. Baumrucker CR, Campana WM, Gibson CA, Kerr DE. Insulin-like growth factors (IGF) and IGF binding proteins in milk; sources and functions. Endocr Regul. 1993 Dec; 27(4):157-72. PMID: 7520764.
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    64. Campana WM, Josephson RV, Patton S. Presence and genetic polymorphism of an epithelial mucin in milk of the goat (Capra hircus). Comp Biochem Physiol B. 1992 Sep; 103(1):261-6. PMID: 1451438.
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