David Coughlin

Title(s)Assistant Clinical Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-4111-0102 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Pennsylvania, PhiladelphiaMTR06/2019Masters in Translational Research
    Pennsylvania Hospital, PhiladelphiaMD06/2019Movement Disorders Fellowship
    University of Pennsylvania Health System, PhiladelphiaPA06/2016Neurology Residency
    Columbia University College of Physicians and Surgeons, New YorkMD05/2012Medical school
    Temple University Hospital, PhiladelphiaMD06/2013Internal Medicine Internship
    Brown University, Providence RIBSc06/2007Neuroscience
    Collapse Awards and Honors
    UC San Diego2021Whitewell Award

    Collapse Overview 
    Collapse Overview
    Movement disorders neurologist and clinician scientist with emerging research program in translational neuropathology. Using immunohistochemistry and image analysis techniques to better understand patterns pathology in neurodegenerative diseases and supporting in vivo biomarker development by advancing biomarker-pathological studies.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Pathological and cognitive correlations of real time quaking induced conversion in LBD and AD
    NIH K23NS120038Jul 15, 2021 - Jun 30, 2026
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology. Biol Sex Differ. 2024 Jan 19; 15(1):8. Bayram E, Coughlin DG, Rajmohan R, Litvan I. PMID: 38243325; PMCID: PMC10797801.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. TDP43 pathology in chronic traumatic encephalopathy retinas. Acta Neuropathol Commun. 2023 09 22; 11(1):152. Phansalkar R, Goodwill VS, Nirschl JJ, De Lillo C, Choi J, Spurlock E, Coughlin DG, Pizzo D, Sigurdson CJ, Hiniker A, Alvarez VE, Mckee AC, Lin JH. PMID: 37737191; PMCID: PMC10515050.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Nitrous Oxide Toxicity With Subsequent Recovery. Neurology. 2023 10 10; 101(15):674-675. DiPane J, Tiem M, Wright BA, Qayoumi W, Coughlin DG. PMID: 37487745; PMCID: PMC10585688.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Case report: Neuronal intranuclear inclusion disease presenting with acute encephalopathy. Front Neurol. 2023; 14:1184612. Bu JT, Torres D, Robinson A, Malone C, Vera JC, Daghighi S, Dunn-Pirio A, Khoromi S, Nowell J, Léger GC, Ciacci JD, Goodwill VS, Estrella M, Coughlin DG, Guo Y, Farid N. PMID: 37332983; PMCID: PMC10272712.
      View in: PubMed   Mentions:
    5. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta Neuropathol. 2023 07; 146(1):31-50. Manca M, Standke HG, Browne DF, Huntley ML, Thomas OR, Orrú CD, Hughson AG, Kim Y, Zhang J, Tatsuoka C, Zhu X, Hiniker A, Coughlin DG, Galasko D, Kraus A. PMID: 37154939; PMCID: PMC10261243.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    6. Fluid and Biopsy Based Biomarkers in Parkinson's Disease. Neurotherapeutics. 2023 07; 20(4):932-954. Coughlin DG, Irwin DJ. PMID: 37138160; PMCID: PMC10457253.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies. J Neuropathol Exp Neurol. 2022 11 16; 81(12):953-964. Coughlin DG, Hiniker A, Peterson C, Kim Y, Arezoumandan S, Giannini L, Pizzo D, Weintraub D, Siderowf A, Litvan I, Rissman RA, Galasko D, Hansen L, Trojanowski JQ, Lee E, Grossman M, Irwin D. PMID: 36269086; PMCID: PMC9677241.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease. Neurology. 2022 11 01; 99(18):e2034-e2043. Salmon DP, Smirnov DS, Coughlin DG, Hamilton JM, Landy KM, Filoteo JV, Hiniker A, Hansen LA, Galasko D. PMID: 36028327; PMCID: PMC9651460.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Selective tau seeding assays and isoform-specific antibodies define neuroanatomic distribution of progressive supranuclear palsy pathology arising in Alzheimer's disease. Acta Neuropathol. 2022 10; 144(4):789-792. Coughlin DG, Goodwill VS, Standke HG, Kim Y, Coley N, Pizzo DP, Galasko D, Kraus A, Hiniker A. PMID: 35980456; PMCID: PMC9467964.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD Diagnoses. Ann Neurol. 2022 10; 92(4):650-662. Arnold MR, Coughlin DG, Brumbach BH, Smirnov DS, Concha-Marambio L, Farris CM, Ma Y, Kim Y, Wilson EN, Kaye JA, Hiniker A, Woltjer RL, Galasko DR, Quinn JF. PMID: 35808984; PMCID: PMC9489647.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    11. Investigational therapeutics for the treatment of progressive supranuclear palsy. Expert Opin Investig Drugs. 2022 Aug; 31(8):813-823. Coughlin DG, Litvan I. PMID: 35695010.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Lateralized ante mortem and post mortem pathology in a case of Lewy body disease with corticobasal syndrome. Alzheimers Dement (N Y). 2022; 8(1):e12294. Coughlin DG, Coslett HB, Peterson C, Phillips JS, McMillan C, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. PMID: 35592691; PMCID: PMC9092750.
      View in: PubMed   Mentions: 1  
    13. Sex Differences for Clinical Correlates of Alzheimer's Pathology in People with Lewy Body Pathology. Mov Disord. 2022 07; 37(7):1505-1515. Bayram E, Coughlin DG, Litvan I. PMID: 35531707; PMCID: PMC9308759.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    14. Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Commun. 2022 03 15; 13(1):1362. Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M. PMID: 35292638; PMCID: PMC8924216.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    15. Physician-Assisted Dying: Access and Utilization in Patients with Movement Disorders. Mov Disord. 2022 04; 37(4):694-698. Damron L, Bayram E, McGehrin K, Reynolds J, Hess R, Coughlin DG, Litvan I. PMID: 35218063.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Neuropathological substrates of cognition in Parkinson's disease. Prog Brain Res. 2022; 269(1):177-193. Coughlin DG, Irwin DJ. PMID: 35248194.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology. Neuropathol Appl Neurobiol. 2022 04; 48(3):e12783. Coughlin DG, Dryden I, Goodwill VS, Pizzo DP, Wright B, Lessig S, Galasko D, MacKenzie IR, Hiniker A. PMID: 34847258; PMCID: PMC9097824.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. A Case of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FET) With Corticobasal Features and Language Deficits. J Neuropathol Exp Neurol. 2021 09 27; 80(9):890-892. Goodwill V, Coughlin D, Pizzo D, Galasko D, Hansen LA, Yuan SH, Hiniker A. PMID: 33969424; PMCID: PMC8476078.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer's disease. Neuropathol Appl Neurobiol. 2021 08; 47(5):707-708. Coughlin DG, Grossman M, Trojanowski JQ, Irwin DJ. PMID: 33492664; PMCID: PMC8298266.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Sex differences for phenotype in pathologically defined dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2021 07; 92(7):745-750. Bayram E, Coughlin DG, Banks SJ, Litvan I. PMID: 33563809; PMCID: PMC8530264.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    21. Progressive Supranuclear Palsy and Corticobasal Degeneration. Adv Exp Med Biol. 2021; 1281:151-176. Coughlin DG, Dickson DW, Josephs KA, Litvan I. PMID: 33433875.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    22. Tau pathology associates with in vivo cortical thinning in Lewy body disorders. Ann Clin Transl Neurol. 2020 12; 7(12):2342-2355. Spotorno N, Coughlin DG, Olm CA, Wolk D, Vaishnavi SN, Shaw LM, Dahodwala N, Morley JF, Duda JE, Deik AF, Spindler MA, Chen-Plotkin A, Lee EB, Trojanowski JQ, McMillan CT, Weintraub D, Grossman M, Irwin DJ. PMID: 33108692; PMCID: PMC7732256.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    23. Multimodal in vivo and postmortem assessments of tau in Lewy body disorders. Neurobiol Aging. 2020 12; 96:137-147. Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, Nasrallah IM, Irwin DJ, McMillan CT, Alzheimer’s Disease Neuroimaging Initiative. PMID: 33002767; PMCID: PMC7819484.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    24. Progressive supranuclear palsy: Advances in diagnosis and management. Parkinsonism Relat Disord. 2020 04; 73:105-116. Coughlin DG, Litvan I. PMID: 32487421; PMCID: PMC7462164.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    25. Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathol. 2020 08; 140(2):99-119. Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM, Trojanowski JQ, Höglinger GU. PMID: 32383020; PMCID: PMC7360645.
      View in: PubMed   Mentions: 137     Fields:    Translation:Humans
    26. Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases. Mov Disord. 2020 01; 35(1):5-19. Coughlin DG, Hurtig HI, Irwin DJ. PMID: 31660655; PMCID: PMC7233798.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    27. Most cases with Lewy pathology in a population-based cohort adhere to the Braak progression pattern but 'failure to fit' is highly dependent on staging system applied. Parkinsonism Relat Disord. 2019 07; 64:124-131. Coughlin DG, Petrovitch H, White LR, Noorigian J, Masaki KH, Ross GW, Duda JE. PMID: 30948243; PMCID: PMC6739131.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Ann Neurol. 2019 02; 85(2):259-271. Coughlin D, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig HI, Branch Coslett H, Hamilton RH, Siderowf AD, Duda JE, Rascovsky K, Lee EB, Lee VM, Grossman M, Trojanowski JQ, Irwin DJ. PMID: 30549331; PMCID: PMC6375484.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    29. Preventing Early Bouncebacks to the Neurointensive Care Unit: A Retrospective Analysis and Quality Improvement Pilot. Neurocrit Care. 2018 04; 28(2):175-183. Coughlin DG, Kumar MA, Patel NN, Hoffman RL, Kasner SE. PMID: 28929392.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Hereditary Myoclonus Dystonia: A Novel SGCE Variant and Phenotype Including Intellectual Disability. Tremor Other Hyperkinet Mov (N Y). 2018; 8:547. Coughlin DG, Bardakjian TM, Spindler M, Deik A. PMID: 29607243; PMCID: PMC5876472.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders. Neurology. 2018 03 20; 90(12):e1038-e1046. Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, Grossman M, Trojanowski JQ. PMID: 29467305; PMCID: PMC5874449.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    32. Emerging Diagnostic and Therapeutic Strategies for Tauopathies. Curr Neurol Neurosci Rep. 2017 Sep; 17(9):72. Coughlin D, Irwin DJ. PMID: 28785992; PMCID: PMC5756477.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    33. Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities. Acta Neuropathol Commun. 2015 Apr 02; 3:17. Sosunov AA, McGovern RA, Mikell CB, Wu X, Coughlin DG, Crino PB, Weiner HL, Ghatan S, Goldman JE, McKhann GM. PMID: 25853525; PMCID: PMC4383198.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    34. The mTOR pathway is activated in glial cells in mesial temporal sclerosis. Epilepsia. 2012 Jun; 53 Suppl 1:78-86. Sosunov AA, Wu X, McGovern RA, Coughlin DG, Mikell CB, Goodman RR, McKhann GM. PMID: 22612812.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
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