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Thomas Hnasko

TitleAssociate Professor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0626
La Jolla CA 92093
Phone858-822-0672
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    Collapse Research 
    Collapse Research Activities and Funding
    Stopping behavior and interrupting cognition via subthalamic nucleus
    NIH/NINDS R01NS106822May 15, 2018 - Apr 30, 2023
    Role: Co-Principal Investigator
    Neurophysiological Characterization of Novel Neurotensin Receptor Ligands to Define Therapeutic Potential in Combatting Addiction
    VA I01BX003759Jan 1, 2018 - Dec 31, 2021
    Role: Principal Investigator
    Novel Molecular Genetic Approaches for the Prevention and Treatment of Parkinsons
    NIH/NINDS R21NS087496Sep 1, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Role of Novel VTA Neurons in Addiction
    NIH/NIDA R01DA036612Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Genetic Elucidation of VTA Glutamate Neurons
    NIH/NIDA K01DA026504Jun 1, 2010 - May 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Faget L, Zell V, Souter E, McPherson A, Ressler R, Gutierrez-Reed N, Yoo JH, Dulcis D, Hnasko TS. Opponent control of behavioral reinforcement by inhibitory and excitatory projections from the ventral pallidum. Nat Commun. 2018 Feb 27; 9(1):849. PMID: 29487284.
      View in: PubMed
    2. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W. Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Mol Psychiatry. 2018 Feb 20. PMID: 29459796.
      View in: PubMed
    3. Steinkellner T, Zell V, Farino ZJ, Sonders MS, Villeneuve M, Freyberg RJ, Przedborski S, Lu W, Freyberg Z, Hnasko TS. Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. J Clin Invest. 2018 Feb 01; 128(2):774-788. PMID: 29337309.
      View in: PubMed
    4. Fife KH, Gutierrez-Reed NA, Zell V, Bailly J, Lewis CM, Aron AR, Hnasko TS. Causal role for the subthalamic nucleus in interrupting behavior. Elife. 2017 07 25; 6. PMID: 28742497.
      View in: PubMed
    5. Denis RGP, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2017 04 04; 25(4):975. PMID: 28380385.
      View in: PubMed
    6. Wang DV, Viereckel T, Zell V, Konradsson-Geuken Å, Broker CJ, Talishinsky A, Yoo JH, Galinato MH, Arvidsson E, Kesner AJ, Hnasko TS, Wallén-Mackenzie Å, Ikemoto S. Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation. Cell Rep. 2017 03 14; 18(11):2584-2591. PMID: 28297663.
      View in: PubMed
    7. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA, Lu W. Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Mol Psychiatry. 2018 May; 23(5):1213-1225. PMID: 28194005.
      View in: PubMed
    8. Yoo JH, Zell V, Wu J, Punta C, Ramajayam N, Shen X, Faget L, Lilascharoen V, Lim BK, Hnasko TS. Activation of Pedunculopontine Glutamate Neurons Is Reinforcing. J Neurosci. 2017 Jan 04; 37(1):38-46. PMID: 28053028.
      View in: PubMed
    9. Yoo JH, Zell V, Gutierrez-Reed N, Wu J, Ressler R, Shenasa MA, Johnson AB, Fife KH, Faget L, Hnasko TS. Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement. Nat Commun. 2016 Dec 15; 7:13697. PMID: 27976722.
      View in: PubMed
    10. Soden ME, Miller SM, Burgeno LM, Phillips PEM, Hnasko TS, Zweifel LS. Genetic Isolation of Hypothalamic Neurons that Regulate Context-Specific Male Social Behavior. Cell Rep. 2016 07 12; 16(2):304-313. PMID: 27346361; PMCID: PMC4945459.
    11. Faget L, Osakada F, Duan J, Ressler R, Johnson AB, Proudfoot JA, Yoo JH, Callaway EM, Hnasko TS. Afferent Inputs to Neurotransmitter-Defined Cell Types in the Ventral Tegmental Area. Cell Rep. 2016 06 21; 15(12):2796-808. PMID: 27292633; PMCID: PMC4917450 [Available on 06/21/17].
    12. Berland C, Cansell C, Hnasko TS, Magnan C, Luquet S. Dietary triglycerides as signaling molecules that influence reward and motivation. Curr Opin Behav Sci. 2016 Jun; 9:126-135. PMID: 28191490.
      View in: PubMed
    13. Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA. Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Mol Metab. 2015 Nov; 4(11):857-66. PMID: 26629409; PMCID: PMC4632173.
    14. Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S. Palatability Can Drive Feeding Independent of AgRP Neurons. Cell Metab. 2015 Oct 06; 22(4):646-57. PMID: 26278050; PMCID: PMC5024566 [Available on 10/06/16].
    15. Hnasko TS, Hnasko RM. The Western Blot. Methods Mol Biol. 2015; 1318:87-96. PMID: 26160567.
      View in: PubMed
    16. Faget L, Hnasko TS. Tyramide Signal Amplification for Immunofluorescent Enhancement. Methods Mol Biol. 2015; 1318:161-72. PMID: 26160574.
      View in: PubMed
    17. Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K. Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci. 2014 Oct 22; 34(43):14304-17. PMID: 25339743; PMCID: PMC4205554.
    18. Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct; 19(10):1095-105. PMID: 24732670; PMCID: PMC4303340.
    19. Trudeau LE, Hnasko TS, Wallén-Mackenzie A, Morales M, Rayport S, Sulzer D. The multilingual nature of dopamine neurons. Prog Brain Res. 2014; 211:141-64. PMID: 24968779; PMCID: PMC4565795.
    20. Delwig A, Majumdar S, Ahern K, LaVail MM, Edwards R, Hnasko TS, Copenhagen DR. Glutamatergic neurotransmission from melanopsin retinal ganglion cells is required for neonatal photoaversion but not adult pupillary light reflex. PLoS One. 2013; 8(12):e83974. PMID: 24391855; PMCID: PMC3877098.
    21. Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron. 2013 Sep 04; 79(5):970-86. PMID: 24012009; PMCID: PMC3768017.
    22. Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, Brownstone RM. Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron. 2013 Apr 10; 78(1):191-204. PMID: 23583114; PMCID: PMC4535710.
    23. Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 2012 Oct 24; 32(43):15076-85. PMID: 23100428; PMCID: PMC3685320.
    24. Hnasko TS, Edwards RH. Neurotransmitter corelease: mechanism and physiological role. Annu Rev Physiol. 2012; 74:225-43. PMID: 22054239; PMCID: PMC4090038.
    25. Talpalar AE, Endo T, Löw P, Borgius L, Hägglund M, Dougherty KJ, Ryge J, Hnasko TS, Kiehn O. Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord. Neuron. 2011 Sep 22; 71(6):1071-84. PMID: 21943604.
      View in: PubMed
    26. Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nat Neurosci. 2011 Aug 28; 14(10):1285-92. PMID: 21874016; PMCID: PMC3183113.
    27. Koch SM, Dela Cruz CG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron. 2011 Jul 28; 71(2):235-42. PMID: 21791283; PMCID: PMC3375067.
    28. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22296-301. PMID: 21135246; PMCID: PMC3009833.
    29. Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci. 2010 Jun 16; 30(24):8229-33. PMID: 20554874; PMCID: PMC2918390.
    30. Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 2010 Mar 11; 65(5):643-56. PMID: 20223200; PMCID: PMC2846457.
    31. Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, Hnasko TS, Palmiter RD, Chavkin C. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19168-73. PMID: 19864633; PMCID: PMC2776420.
    32. Hnasko TS, Sotak BN, Palmiter RD. Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. J Neurosci. 2007 Nov 14; 27(46):12484-8. PMID: 18003826.
      View in: PubMed
    33. Hnasko TS, Hnasko RM, Sotak BN, Kapur RP, Palmiter RD. Genetic disruption of dopamine production results in pituitary adenomas and severe prolactinemia. Neuroendocrinology. 2007; 86(1):48-57. PMID: 17622754.
      View in: PubMed
    34. Robinson S, Rainwater AJ, Hnasko TS, Palmiter RD. Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice. Psychopharmacology (Berl). 2007 Apr; 191(3):567-78. PMID: 17093978.
      View in: PubMed
    35. Hnasko TS, Edwards RH. Synaptic vesicles: half full or half empty? Neuron. 2006 Sep 07; 51(5):523-4. PMID: 16950150.
      View in: PubMed
    36. Hnasko TS, Perez FA, Scouras AD, Stoll EA, Gale SD, Luquet S, Phillips PE, Kremer EJ, Palmiter RD. Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. Proc Natl Acad Sci U S A. 2006 Jun 06; 103(23):8858-63. PMID: 16723393; PMCID: PMC1466546.
    37. Hnasko TS, Sotak BN, Palmiter RD. Morphine reward in dopamine-deficient mice. Nature. 2005 Dec 08; 438(7069):854-7. PMID: 16341013.
      View in: PubMed
    38. Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science. 2005 Oct 28; 310(5748):683-5. PMID: 16254186.
      View in: PubMed
    39. Sotak BN, Hnasko TS, Robinson S, Kremer EJ, Palmiter RD. Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding. Brain Res. 2005 Nov 09; 1061(2):88-96. PMID: 16226228.
      View in: PubMed
    40. Hnasko TS, Szczypka MS, Alaynick WA, During MJ, Palmiter RD. A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 2004 Oct 15; 1023(2):309-18. PMID: 15374756.
      View in: PubMed
    41. Heusner CL, Hnasko TS, Szczypka MS, Liu Y, During MJ, Palmiter RD. Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine. Brain Res. 2003 Aug 08; 980(2):266-74. PMID: 12867267.
      View in: PubMed