Xu Qiao Chen

Title(s)	Assistant Project Scientist, Neurosciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome. Ann Neurol. 2024 Aug; 96(2):390-404. Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC. PMID: 38747498; PMCID: PMC11236496.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals
New insights into the effects of APP gene dose on synapse in Down syndrome. Neural Regen Res. 2024 May; 19(5):961-962. Chen XQ, Zuo X. PMID: 37862189; PMCID: PMC10749626.

View in: PubMed Mentions:
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease. Neurobiol Dis. 2024 Jun 01; 195:106502. Gu Y, Pope A, Smith C, Carmona C, Johnstone A, Shi L, Chen X, Santos S, Bacon-Brenes CC, Shoff T, Kleczko KM, Frydman J, Thompson LM, Mobley WC, Wu C. PMID: 38608784.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Synaptic dysfunction in Down syndrome: an emerging role for circulating β2-microglobulin. Signal Transduct Target Ther. 2023 05 29; 8(1):223. Chen XQ. PMID: 37248265; PMCID: PMC10227068.

View in: PubMed Mentions: Fields:
Cel Cell Biology Dru Drug Therapy
Translation:Humans
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator. Ann Neurol. 2023 08; 94(2):245-258. Chen XQ, Sawa M, Becker A, Karachentsev D, Zuo X, Rynearson KD, Tanzi RE, Mobley WC. PMID: 37042072.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Humans Animals Cells
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose. Alzheimers Dement. 2023 05; 19(5):2095-2116. Chen XQ, Zuo X, Becker A, Head E, Mobley WC. PMID: 36370135; PMCID: PMC10175517.

View in: PubMed Mentions: 4 Fields:
Neu Neurology Psy Psychiatry
Translation:Animals
Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 07; 13(12). Chen XQ, Barrero CA, Vasquez-Del Carpio R, Reddy EP, Fecchio C, Merali S, Deglincerti A, Fang C, Rogers J, Maccecchini ML. PMID: 34959389; PMCID: PMC8708689.

View in: PubMed Mentions: 3
A pilot exploration with Posiphen to normalize amyloid precursor protein in Down syndrome. Neural Regen Res. 2021 Dec; 16(12):2420-2421. Chen XQ. PMID: 33907026; PMCID: PMC8374580.

View in: PubMed Mentions: 3
Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome. Front Aging Neurosci. 2021; 13:700280. Chen XQ, Xing Z, Chen QD, Salvi RJ, Zhang X, Tycko B, Mobley WC, Yu YE. PMID: 34276349; PMCID: PMC8281234.

View in: PubMed Mentions: 9
Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. Alzheimers Res Ther. 2021 03 10; 13(1):59. Chen XQ, Das U, Park G, Mobley WC. PMID: 33691783; PMCID: PMC7945332.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Animals
Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2021 02; 17(2):271-292. Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. PMID: 32975365; PMCID: PMC7984396.

View in: PubMed Mentions: 25 Fields:
Neu Neurology Psy Psychiatry
Translation:Humans Animals Cells
Calcium-sensing receptor bridges calcium and telomerase reverse transcriptase in gastric cancers via Akt. Clin Transl Oncol. 2020 Jul; 22(7):1023-1032. Xie R, Tuo B, Yang S, Chen XQ, Xu J. PMID: 31650467.

View in: PubMed Mentions: 2 Fields:
Neo Neoplasms
Translation:Humans Cells
Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species. Front Neurosci. 2019; 13:659. Chen XQ, Mobley WC. PMID: 31293377; PMCID: PMC6598402.

View in: PubMed Mentions: 114
Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses. Front Neurosci. 2019; 13:446. Chen XQ, Mobley WC. PMID: 31133787; PMCID: PMC6514132.

View in: PubMed Mentions: 71
Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation. Neural Regen Res. 2019 Apr; 14(4):588-590. Chen XQ. PMID: 30632495; PMCID: PMC6352588.

View in: PubMed Mentions: 3
The Role of TGF-β and Its Receptors in Gastrointestinal Cancers. Transl Oncol. 2019 Mar; 12(3):475-484. Luo J, Chen XQ, Li P. PMID: 30594036; PMCID: PMC6314240.

View in: PubMed Mentions: 42
T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 11; 19(11):840-853. Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. PMID: 30120810; PMCID: PMC6191364.

View in: PubMed Mentions: 15 Fields:
Phy Physiology
Translation:Humans Animals Cells
Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors. Mol Pain. 2018 Jan-Dec; 14:1744806918769492. Bao F, Li CL, Chen XQ, Lu YJ, Bao L, Zhang X. PMID: 29587571; PMCID: PMC5898661.

View in: PubMed Mentions: 2 Fields:
Mol Molecular Biology Neu Neurology Psy Psychophysiology
Translation:Humans Animals Cells
Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018 03 08; 9(1):1007. Mo Z, Zhao X, Liu H, Hu Q, Chen XQ, Pham J, Wei N, Liu Z, Zhou J, Burgess RW, Pfaff SL, Caskey CT, Wu C, Bai G, Yang XL. PMID: 29520015; PMCID: PMC5843656.

View in: PubMed Mentions: 53 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome. Free Radic Biol Med. 2018 01; 114:52-61. Chen XQ, Sawa M, Mobley WC. PMID: 29031834; PMCID: PMC5748266.

View in: PubMed Mentions: 35 Fields:
Bio Biochemistry Med Medicine (General)
Translation:Humans Animals Cells
Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Sci Rep. 2017 06 20; 7(1):3868. Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C. PMID: 28634349; PMCID: PMC5478665.

View in: PubMed Mentions: 43 Fields:
Sci Science
Translation:Animals Cells
TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5655-64. Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. PMID: 27601642; PMCID: PMC5035849.

View in: PubMed Mentions: 49 Fields:
Sci Science
Translation:Humans Animals Cells
CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor. J Mol Cell Biol. 2014 Apr; 6(2):140-53. Chen XQ, Zhu JX, Wang Y, Zhang X, Bao L. PMID: 24755854.

View in: PubMed Mentions: 10 Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res. 2012 Apr; 22(4):677-96. Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X, Bao L. PMID: 22157653; PMCID: PMC3317558.

View in: PubMed Mentions: 21 Fields:
Cel Cell Biology
Translation:Humans Animals Cells