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Enriching the design of Alzheimer's disease clinical trials: Application of the polygenic hazard score and composite outcome measures. Alzheimers Dement (N Y). 2020; 6(1):e12071.
Banks SJ, Qiu Y, Fan CC, Dale AM, Zou J, Askew B, Feldman HH, Alzheimer's Disease Neuroimaging Initiative. PMID: 32999917; PMCID: PMC7507583.
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PubMed Mentions:
5
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Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS-Cog-Exec. Alzheimers Dement (N Y). 2020; 6(1):e12059.
Jacobs DM, Thomas RG, Salmon DP, Jin S, Feldman HH, Cotman CW, Baker LD, Alzheimer's Disease Cooperative Study EXERT Study Group, Alzheimer's Disease Neuroimaging Initiative. PMID: 32995469; PMCID: PMC7507362.
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PubMed Mentions:
4
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Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults. Neurology. 2020 10 20; 95(16):e2295-e2304.
Weigand AJ, Bondi MW, Thomas KR, Campbell NL, Galasko DR, Salmon DP, Sewell D, Brewer JB, Feldman HH, Delano-Wood L, Alzheimer's Disease Neuroimaging Initiative. PMID: 32878992; PMCID: PMC7713781.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer's disease. Prog Neurobiol. 2021 02; 197:101902.
Kent BA, Feldman HH, Nygaard HB. PMID: 32877742; PMCID: PMC7855222.
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PubMed Mentions:
19 Fields:
Translation:
Humans
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World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020 07; 16(7):1078-1094.
Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas RM, Scheltens P, Sevlever G, Soininen H, Sosa AL, Suemoto CK, Tainta-Cuezva M, Velilla L, Wang Y, Whitmer R, Whitmer R, Xu X, Bain LJ, Solomon A, Ngandu T, Carrillo MC. PMID: 32627328; PMCID: PMC9527644.
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PubMed Mentions:
119 Fields:
Translation:
Humans
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Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS). J Neuropathol Exp Neurol. 2020 07 01; 79(7):809-812.
Chornenka K, Hirsch-Reinshagen V, Perez-Rosendahl M, Feldman H, Segal-Gidan F, Vinters HV, Mackenzie IR. PMID: 32483606.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 03 16; 15(1):21.
Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, Roberge M, Nygaard HB. PMID: 32178712; PMCID: PMC7075020.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Alzheimers Dement. 2020 01; 16(1):131-143.
Boxer AL, Gold M, Feldman H, Boeve BF, Dickinson SL, Fillit H, Ho C, Paul R, Pearlman R, Sutherland M, Verma A, Arneric SP, Alexander BM, Dickerson BC, Dorsey ER, Grossman M, Huey ED, Irizarry MC, Marks WJ, Masellis M, McFarland F, Niehoff D, Onyike CU, Paganoni S, Panzara MA, Rockwood K, Rohrer JD, Rosen H, Schuck RN, Soares HD, Tatton N. PMID: 31668596; PMCID: PMC6949386.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation. Stem Cell Res. 2019 12; 41:101582.
Frew J, Wu X, Hsiung GY, Feldman HH, Mackenzie IR, Nygaard HB. PMID: 31707213.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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The "rights" of precision drug development for Alzheimer's disease. Alzheimers Res Ther. 2019 08 31; 11(1):76.
Cummings J, Feldman HH, Scheltens P. PMID: 31470905; PMCID: PMC6717388.
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PubMed Mentions:
80 Fields:
Translation:
Humans
-
A randomized clinical trial to evaluate home-based assessment of people over 75 years old. Alzheimers Dement. 2019 05; 15(5):615-624.
Sano M, Zhu CW, Kaye J, Mundt JC, Hayes TL, Ferris S, Thomas RG, Sun CK, Jiang Y, Donohue MC, Schneider LS, Egelko S, Aisen PS, Feldman HH, Alzheimer Disease Cooperative Study Investigators. PMID: 30872114.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neurobiol Aging. 2019 06; 78:74-86.
Kent BA, Michalik M, Marchant EG, Yau KW, Feldman HH, Mistlberger RE, Nygaard HB. PMID: 30884411.
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PubMed Mentions:
13 Fields:
Translation:
Animals
-
Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY). Alzheimers Res Ther. 2018 09 27; 10(1):102.
Finger E, Berry S, Cummings J, Coleman K, Hsiung R, Feldman HH, Boxer A. PMID: 30261917; PMCID: PMC6161323.
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PubMed Mentions:
16 Fields:
Translation:
HumansCTClinical Trials
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16-Year Survival of the Canadian Collaborative Cohort of Related Dementias. Can J Neurol Sci. 2018 07; 45(4):367-374.
Lichtenstein ML, Fallah N, Mudge B, Hsiung GR, Foti D, Beattie BL, Feldman HH. PMID: 29730995.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers. Neuroimage Clin. 2018; 18:591-598.
Popuri K, Dowds E, Beg MF, Balachandar R, Bhalla M, Jacova C, Buller A, Slack P, Sengdy P, Rademakers R, Wittenberg D, Feldman HH, Mackenzie IR, Hsiung GR. PMID: 29845007; PMCID: PMC5964622.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Neurobehavioral characterization of adult-onset Alexander disease: A family study. Neurol Clin Pract. 2017 Oct; 7(5):425-429.
Lichtenstein ML, Dwosh E, Roy Chowdhury A, Farrer MJ, McKenzie MB, Guella I, Evans DM, Nygaard HB, Shewchuk JR, Hayden S, Barton JJS, Feldman HH. PMID: 29620072; PMCID: PMC5874457.
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PubMed Mentions:
2
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Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017 Jul 04; 89(1):88-100.
McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K. PMID: 28592453; PMCID: PMC5496518.
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PubMed Mentions:
1184 Fields:
Translation:
Humans
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The Canadian dementia challenge: Ensuring optimal care and services for those at risk or with dementia throughout the country. Can J Public Health. 2017 04 20; 108(1):e95-e97.
Feldman HH, Estabrooks CA. PMID: 28425906; PMCID: PMC6975213.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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The 2002 NIMH Provisional Diagnostic Criteria for Depression of Alzheimer's Disease (PDC-dAD): Gauging their Validity over a Decade Later. J Alzheimers Dis. 2017; 58(2):449-462.
Sepehry AA, Lee PE, Hsiung GR, Beattie BL, Feldman HH, Jacova C. PMID: 28453472.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. Lancet. 2016 12 10; 388(10062):2873-2884.
Gauthier S, Feldman HH, Schneider LS, Wilcock GK, Frisoni GB, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Wischik DJ, Schelter BO, Davis CS, Staff RT, Bracoud L, Shamsi K, Storey JM, Harrington CR, Wischik CM. PMID: 27863809; PMCID: PMC5164296.
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PubMed Mentions:
152 Fields:
Translation:
HumansAnimalsCTClinical Trials
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A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology. 2016 Aug 02; 87(5):539-47.
Jack CR, Bennett DA, Blennow K, Carrillo MC, Feldman HH, Frisoni GB, Hampel H, Jagust WJ, Johnson KA, Knopman DS, Petersen RC, Scheltens P, Sperling RA, Dubois B. PMID: 27371494; PMCID: PMC4970664.
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PubMed Mentions:
653 Fields:
Translation:
Humans
-
Defeating Alzheimer's disease and other dementias: a priority for European science and society. Lancet Neurol. 2016 Apr; 15(5):455-532.
Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H. PMID: 26987701.
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PubMed Mentions:
545 Fields:
Translation:
Humans
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Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016 Mar; 12(3):292-323.
Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, O'Bryant SE, Rabinovici GD, Rowe C, Salloway S, Schneider LS, Sperling R, Teichmann M, Carrillo MC, Cummings J, Jack CR, Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Ass. PMID: 27012484; PMCID: PMC6417794.
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PubMed Mentions:
635 Fields:
Translation:
HumansAnimals
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Periventricular hyperintensities are associated with elevated cerebral amyloid. Neurology. 2016 Feb 09; 86(6):535-43.
Marnane M, Al-Jawadi OO, Mortazavi S, Pogorzelec KJ, Wang BW, Feldman HH, Hsiung GY, Alzheimer's Disease Neuroimaging Initiative. PMID: 26747881; PMCID: PMC4753726.
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PubMed Mentions:
38 Fields:
Translation:
Humans
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Effect of diesel exhaust inhalation on blood markers of inflammation and neurotoxicity: a controlled, blinded crossover study. Inhal Toxicol. 2016; 28(3):145-53.
Cliff R, Curran J, Hirota JA, Brauer M, Feldman H, Carlsten C. PMID: 26915823.
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PubMed Mentions:
10 Fields:
Translation:
HumansPHPublic Health
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Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial. JAMA Neurol. 2015 Nov; 72(11):1324-33.
Coric V, Salloway S, van Dyck CH, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Pilcher G, Ferris S, Colby S, Kerselaers W, Dockens R, Soares H, Kaplita S, Luo F, Pachai C, Bracoud L, Mintun M, Grill JD, Marek K, Seibyl J, Cedarbaum JM, Albright C, Feldman HH, Berman RM. PMID: 26414022.
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PubMed Mentions:
96 Fields:
Translation:
HumansCTClinical Trials
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Early neuropsychological characteristics of progranulin mutation carriers. J Int Neuropsychol Soc. 2014 Aug; 20(7):694-703.
Hallam BJ, Jacova C, Hsiung GY, Wittenberg D, Sengdy P, Bouchard-Kerr P, Slack P, Rademakers R, Baker M, Chow TW, Levine B, Feldman HH, Mackenzie IR. PMID: 24993774.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014 Jun; 13(6):614-29.
Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL. PMID: 24849862.
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PubMed Mentions:
1238 Fields:
Translation:
Humans
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Alzheimer's disease research and development: a call for a new research roadmap. Ann N Y Acad Sci. 2014 Apr; 1313:1-16.
Feldman HH, Haas M, Gandy S, Schoepp DD, Cross AJ, Mayeux R, Sperling RA, Fillit H, van de Hoef DL, Dougal S, Nye JS, One Mind for Research and the New York Academy of Sciences. PMID: 24754377.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population. Neurobiol Aging. 2014 Apr; 35(4):936.e5-12.
Omoumi A, Fok A, Greenwood T, Sadovnick AD, Feldman HH, Hsiung GY. PMID: 24176626.
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PubMed Mentions:
24 Fields:
Translation:
Humans
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Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers. Neurology. 2013 Oct 08; 81(15):1322-31.
Jacova C, Hsiung GY, Tawankanjanachot I, Dinelle K, McCormick S, Gonzalez M, Lee H, Sengdy P, Bouchard-Kerr P, Baker M, Rademakers R, Sossi V, Stoessl AJ, Feldman HH, Mackenzie IR. PMID: 24005336; PMCID: PMC3806924.
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PubMed Mentions:
34 Fields:
Translation:
Humans
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Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia. Alzheimers Res Ther. 2013 Jul 08; 5(Suppl 1):S2.
Chertkow H, Feldman HH, Jacova C, Massoud F. PMID: 24565215; PMCID: PMC3981054.
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PubMed Mentions:
54 Fields:
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Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimers Dement. 2013 Mar; 9(2):123-131.e1.
Carrillo MC, Brashear HR, Logovinsky V, Ryan JM, Feldman HH, Siemers ER, Abushakra S, Hartley DM, Petersen RC, Khachaturian AS, Sperling RA. PMID: 23411394.
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PubMed Mentions:
52 Fields:
Translation:
HumansPHPublic Health
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H.L. v. Matheson: where does the Court stand on abortion and parental notification? Am Univ Law Rev. 1982; 31(2):431-69.
Feldman HN. PMID: 11658318.
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PubMed Mentions: Fields:
Translation:
Humans