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Howard Feldman

Photo of Howard Feldman
Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-9258-4538 Additional info
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    Collapse Biography 
    Collapse education and training
    McGill University, Quebec, CanadaMDCM06/1978Medicine
    Collapse awards and honors
    University of British Columbia1997Martin M Hoffman Award for Excellence in Research
    Thomson Reuters2002  - 2012Most Highly Cited Researchers in Neuroscience & Behavior; World's Most Influential Scientific Mind
    Web of Science Clarivate Analytics2007  - 2018Top 1% Most Cited Researcher in Neuroscience
    University of British Columbia2008Distinguished Achievement Award for Outstanding Contribution by a Senior Faculty Member
    Canadian Consortium of Clinical Cognitive Centres for Research (C5R)2013Irma M Parhad Award for Excellence
    Thomson Reuters2014  - 2015Most Highly Cited Researchers in Neuroscience & Behavior; World's Most Influential Scientific Mind
    Blue Ridge Institute for Medical Research2019#1 ranking PI in Neurosciences funding from the NIH

    Collapse Overview 
    Collapse webpage

    Collapse Research 
    Collapse research activities and funding
    Asian Cohort for Alzheimer's Disease (ACAD)
    NIH U19AG079774Jul 1, 2023 - Jun 30, 2028
    Role: Co-Investigator
    Phase II randomized controlled trial of benfotiamine in early Alzheimer's Disease
    NIH R01AG076634Jul 15, 2022 - Jun 30, 2027
    Role: Principal Investigator
    A Single Ascending Dose / Multiple Ascending Dose Phase I study of the GSM 776890 in healthy normal subjects
    NIH R01AG070353Feb 1, 2021 - Nov 30, 2023
    Role: Coordinating Center Principal Investigator
    UCSD Alzheimer's Disease Research Centers P30
    NIH P30AG062429May 1, 2019 - Mar 31, 2024
    Role: Co-Investigator
    Canadian Consortium on Neurodegeneration and Aging (CCNA)
    Canadian Institutes of Health Research (CIHR) 137794Apr 1, 2019 - Mar 31, 2024
    Role: Co-Principal Investigator
    Description: This grant funds a national network investigating prevention, quality of life, and treatment. It includes the COMPASS-ND, and the CAN THUMBS UP program
    A Seamless Phase 2A-B Randomized Double Blind Placebo Controlled Trial to Evaluate the Efficacy and Safety of PQ 912 in Patients with Early Alzheimer's Disease
    NIH R01AG061146Apr 1, 2019 - Jun 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An International Working Group viewpoint on stratifying risk and prevention of the clinical expression of Alzheimer's disease. Nat Aging. 2025 Oct; 5(10):1930-1932. Feldman HH, Villain N, Frisoni GB, Dubois B. PMID: 40983695.
      View in: PubMed   Mentions:    Fields:    
    2. Implications of practice effects for the design of Alzheimer clinical trials. Alzheimers Dement (N Y). 2025 Jul-Sep; 11(3):e70154. Duehring JA, Jacobs DM, Thomas ML, Dodge HH, Feldman HH, Edland SD. PMID: 40936998; PMCID: PMC12420670.
      View in: PubMed   Mentions:
    3. IWG and AA Criteria-Where the Differences Matter-Reply. JAMA Neurol. 2025 Jun 01; 82(6):629-630. Dubois B, Villain N, Feldman HH. PMID: 40257771.
      View in: PubMed   Mentions:    Fields:    
    4. The International Working Group recommendations on cognitively unimpaired individuals. Lancet Neurol. 2025 Jun; 24(6):481. Villain N, Frisoni GB, Feldman HH, Dubois B. PMID: 40409306.
      View in: PubMed   Mentions:    Fields:    
    5. Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study. Alzheimers Dement. 2025 Jun; 21(6):e70311. Lee H, Tzuang M, Chow TW, Kang Y, Tee BL, Li C, Lam E, Gu Y, Lee S, Ho PC, Peavy G, Seo EH, Kim K, Tran B, Chae W, Nguyen D, Vo N, Dang D, Spat-Lemus J, Choi YB, Feldman H, Jun GR, Wang LS, Yu WH, Park VTM, Asian Cohort for Alzheimer's Disease Study. PMID: 40528300; PMCID: PMC12173839.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer's disease. Alzheimers Res Ther. 2025 May 02; 17(1):97. Qiu Y, Jacobs DM, Messer K, Salmon DP, Wellington CL, Stukas S, Revta C, Brewer JB, Léger GC, Askew B, Donahue L, Kaplita S, Coric V, Qureshi IA, Feldman HH, Alzheimer’s Disease Cooperative Study T2 Protect AD Study Group. PMID: 40317057; PMCID: PMC12046789.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    7. Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI. Alzheimers Dement. 2025 Apr; 21(4):e70118. Shadyab AH, Aslanyan V, Jacobs DM, Salmon DP, Morrison R, Katula JA, Jin S, Thomas RG, LaCroix AZ, Pa J, Cotman CW, Feldman HH, Baker LD, ADCS EXERT Study Group. PMID: 40271887; PMCID: PMC12019695.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study. Alzheimers Dement. 2025 Apr; 21(4):e14586. Baker LD, Pa JA, Katula JA, Aslanyan V, Salmon DP, Jacobs DM, Chmelo EA, Hodge H, Morrison R, Matthews G, Brewer J, Jung Y, Rissman RA, Taylor C, Léger GC, Messer K, Evans AC, Okonkwo OC, Shadyab AH, Zou J, Jin S, Thomas RG, Zhang J, La Croix AZ, Cotman CW, Feldman HH, EXERT Study Group. PMID: 40271888; PMCID: PMC12019696.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    9. Brain health PRO/Santé cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction. J Prev Alzheimers Dis. 2025 Jun; 12(6):100134. Belleville S, Anderson ND, Bherer L, Camicioli R, Carrier J, Chan S, Cuesta M, Dang-Vu TT, Dwosh E, Fiocco AJ, Ferland G, Gilbert B, Harris E, Itzhak I, Jarrett P, Kadri MA, Laurin D, Liu-Ambrose T, McGibbon CA, Middleton L, Miller L, Nygaard HB, Montero-Odasso M, Murphy K, Phillips N, Pichora-Fuller MK, Robillard JM, Smith EE, Speechley M, Trigui A, Wittich W, Chertkow H, Feldman HH, CTU expert group for the Canadian Consortium on Neurodegeneration in Aging (CCNA), CAN-THUMBS UP Stu. PMID: 40090784; PMCID: PMC12434268.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    10. Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer's disease. Alzheimers Res Ther. 2025 Mar 11; 17(1):59. Ketron GL, Grun F, Grill JD, Feldman HH, Rissman RA, Brewer GJ. PMID: 40069789; PMCID: PMC11895359.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    11. Intranasal oxytocin for apathy in people with frontotemporal dementia (FOXY): a multicentre, randomised, double-blind, placebo-controlled, adaptive, crossover, phase 2a/2b superiority trial. Lancet Neurol. 2025 Feb; 24(2):128-139. Coleman KKL, Berry S, Cummings J, Hsiung GR, Laforce R, Huey E, Ducharme S, Tartaglia MC, Mendez MF, Onyike C, Domoto-Reilly K, Masellis M, Herrmann N, Porsteinsson A, Detry MA, Stewart C, Bosse AL, McGlothlin A, Dias B, Pandey S, Mayich M, Pasternak SH, Ruiz Garcia R, Restrepo-Martinez M, Feldman H, Boxer AL, Finger EC. PMID: 39862881.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    12. Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts. Geroscience. 2025 Aug; 47(4):5619-5634. Wang L, Hu W, Dong F, Sheng C, Wu J, Han Y, Jiang J, Alzheimer’s Disease Neuroimaging Initiative, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowski JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Shaw LM, Khachaturian Z, Sorensen G, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam MM, Potter W, Snyder P, Schwartz A, Montine T, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Bernstein M, Thompson P, Schuff N, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe RA, Foster N, Reiman EM, Chen K, Mathis C, Landau S, Cairns NJ, Householder E, Taylor-Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud TM, Potkin SG, Shen L, Faber K, Kim S, Nho K, Thal L, Buckholtz N, Albert M, Frank R, Hsiao J, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider LS, Pawluczyk S, Beccera M, Teodoro L, Spann BM, Brewer J, Vanderswag H, Fleisher A, Heidebrink JL, Lord JL, Mason SS, Albers CS, Knopman D, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig LS, Bell KL, Ances B, Carroll M, Leon S, Mintun MA, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geldmacher D, Brockington J, Roberson E, Grossman H, Mitsis E, de Toledo-Morrell L, Shah RC, Duara R, Varon D, Greig MT, Roberts P, Onyike C, D'Agostino D, Kielb S, Galvin JE, Cerbone B, Michel CA, Rusinek H, de Leon MJ, Glodzik L, De Santi S, Doraiswamy P, Petrella JR, Wong TZ, Arnold SE, Karlawish JH, Wolk D, Smith CD, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez OL, Oakley M, Simpson DM, Porsteinsson AP, Goldstein BS, Martin K, Makino KM, Ismail M, Brand C, Mulnard RA, Thai G, McAdams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Swerdlow RH, Apostolova L, Tingus K, Woo E, Silverman DHS, Lu PH, Bartzokis G, Graff-Radford NR, Parfitt F, Kendall T, Johnson H, Farlow MR, Hake AM, Matthews BR, Herring S, Hunt C, van Dyck CH, Carson RE, MacAvoy MG, Chertkow H, Bergman H, Hosein C, Hsiung GR, Feldman H, Mudge B, Assaly M, Bernick C, Munic D, Kertesz A, Rogers J, Trost D, Kerwin D, Lipowski K, Wu CK, Johnson N, Sadowsky C, Martinez W, Villena T, Turner RS, Johnson K, Reynolds B, Sperling RA, Johnson KA, Marshall G, Frey M, Lane B, Rosen A, Tinklenberg J, Sabbagh MN, Belden CM, Jacobson SA, Sirrel SA, Kowall N, Killiany R, Budson AE, Norbash A, Johnson PL, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichae O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee TY, Bartha R, Johnson S, Asthana S, Carlsson CM, Preda A, Nguyen D, Tariot P, Reeder S, Bates V, et al. PMID: 39888585; PMCID: PMC12397043.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research. J Prev Alzheimers Dis. 2025 Mar; 12(3):100068. Smith EE, Phillips NA, Feldman HH, Borrie M, Ganesh A, Henri-Bhargava A, Desmarais P, Frank A, Badhwar A, Barlow L, Bartha R, Best S, Bethell J, Bhangu J, Black SE, Bocti C, Bronskill SE, Burhan AM, Calon F, Camicioli R, Campbell B, Collins DL, Dadar M, DeMarco ML, Ducharme S, Duchesne S, Einstein G, Fisk JD, Gawryluk JR, Grossman L, Ismail Z, Itzhak I, Joshi M, Harrison A, Kröger E, Kumar S, Laforce R, Lanctot KL, Lau M, Lee L, Masellis M, Massoud F, Mitchell SB, Montero-Odasso M, Myers Barnett K, Nygaard HB, Pasternak SH, Peters J, Rajah MN, Robillard JM, Rockwood K, Rosa-Neto P, Seitz DP, Soucy JP, Trenaman SC, Wellington CL, Zadem A, Chertkow H, Canadian Consortium on Neurodegeneration in Aging Investigators. PMID: 39893139; PMCID: PMC12184013.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Tailoring implementation strategies for the healthy actions and lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program: Lessons learned from a survey study. J Prev Alzheimers Dis. 2025 Mar; 12(3):100053. Moukarzel S, Araujo-Menendez CEE, Galang E, Zlatar ZZ, Feldman HH, Banks SJ, HALT-AD Study Group. PMID: 39827004; PMCID: PMC12184062.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease. Alzheimers Res Ther. 2025 Jan 08; 17(1):14. Cummings JL, Atri A, Feldman HH, Hansson O, Sano M, Knop FK, Johannsen P, León T, Scheltens P. PMID: 39780249; PMCID: PMC11708093.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    16. Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease. Neurology. 2025 Jan 14; 104(1):e210152. Grill JD, Tam S, Thai G, Vides B, Pierce AL, Green K, Gillen DL, Teng E, Kremen S, Beigi M, Rissman RA, Léger GC, Balasubramanian A, Revta C, Morrison R, Jennings R, Pa J, Zhang J, Jin S, Messer K, Feldman HH. PMID: 39671543; PMCID: PMC11655133.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    17. Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA). J Alzheimers Dis. 2024 Dec; 102(3):535-561. Chertkow H, Phillips N, Rockwood K, Anderson N, Andrew MK, Bartha R, Beaudoin C, Bélanger N, Bellec P, Belleville S, Bergman H, Best S, Bethell J, Bherer L, Black S, Borrie M, Camicioli R, Carrier J, Cashman N, Chan S, Crowshoe L, Cuello C, Cynader M, Dang-Vu T, Das S, Dixon RA, Ducharme S, Einstein G, Evans AC, Fahnestock M, Feldman H, Ferland G, Finger E, Fisk JD, Fogarty J, Fon E, Gan-Or Z, Gauthier S, Greenwood C, Henri-Bellemare C, Herrmann N, Hogan DB, Hsiung R, Itzhak I, Jacklin K, Lanctôt K, Lim A, MacKenzie I, Masellis M, Maxwell C, McAiney C, McGilton K, McLaurin J, Mihailidis A, Mohades Z, Montero-Odasso M, Morgan D, Naglie G, Nygaard H, O'Connell M, Petersen R, Pilon R, Rajah MN, Rapoport M, Roach P, Robillard JM, Rogaeva E, Rosa-Neto P, Rylett J, Sadavoy J, St George-Hyslop P, Seitz D, Smith E, Stefanovic B, Vedel I, Walker JD, Wellington C, Whitehead V, Wittich W. PMID: 39636028.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Alzheimer Disease as a Clinical-Biological Construct-An International Working Group Recommendation. JAMA Neurol. 2024 Dec 01; 81(12):1304-1311. Dubois B, Villain N, Schneider L, Fox N, Campbell N, Galasko D, Kivipelto M, Jessen F, Hanseeuw B, Boada M, Barkhof F, Nordberg A, Froelich L, Waldemar G, Frederiksen KS, Padovani A, Planche V, Rowe C, Bejanin A, Ibanez A, Cappa S, Caramelli P, Nitrini R, Allegri R, Slachevsky A, de Souza LC, Bozoki A, Widera E, Blennow K, Ritchie C, Agronin M, Lopera F, Delano-Wood L, Bombois S, Levy R, Thambisetty M, Georges J, Jones DT, Lavretsky H, Schott J, Gatchel J, Swantek S, Newhouse P, Feldman HH, Frisoni GB. PMID: 39483064; PMCID: PMC12010406.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    19. Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer's disease, positive for plasma p-tau217. Alzheimers Res Ther. 2024 Nov 23; 16(1):254. Kovacech B, Cullen NC, Novak P, Hanes J, Kontsekova E, Katina S, Parrak V, Fresser M, Vanbrabant J, Feldman HH, Winblad B, Stoops E, Vanmechelen E, Zilka N. PMID: 39580468; PMCID: PMC11585249.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    20. A framework for translating tauopathy therapeutics: Drug discovery to clinical trials. Alzheimers Dement. 2024 Nov; 20(11):8129-8152. Feldman HH, Cummings JL, Boxer AL, Staffaroni AM, Knopman DS, Sukoff Rizzo SJ, Territo PR, Arnold SE, Ballard C, Beher D, Boeve BF, Dacks PA, Diaz K, Ewen C, Fiske B, Gonzalez MI, Harris GA, Hoffman BJ, Martinez TN, McDade E, Nisenbaum LK, Palma JA, Quintana M, Rabinovici GD, Rohrer JD, Rosen HJ, Troyer MD, Kim DY, Tanzi RE, Zetterberg H, Ziogas NK, May PC, Rommel A. PMID: 39316411; PMCID: PMC11567863.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. Asian Cohort for Alzheimer Disease (ACAD) Pilot Study: Vietnamese Americans. Alzheimer Dis Assoc Disord. 2024 Jul-Sep 01; 38(3):277-284. Peavy GM, Võ N, Revta C, Lu AT, Lupo JL, Nam P, Nguy?n KH, Wang LS, Feldman HH. PMID: 39177172; PMCID: PMC11340683.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. Relationships between plasma biomarkers, tau PET, FDG PET, and volumetric MRI in mild to moderate Alzheimer's disease patients. Alzheimers Dement (N Y). 2024 Jul-Sep; 10(3):e12490. Matthews DC, Kinney JW, Ritter A, Andrews RD, Toledano Strom EN, Lukic AS, Koenig LN, Revta C, Fillit HM, Zhong K, Tousi B, Leverenz JB, Feldman HH, Cummings J. PMID: 38988416; PMCID: PMC11233274.
      View in: PubMed   Mentions: 5  
    23. A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer's Disease. Alzheimers Res Ther. 2024 07 05; 16(1):151. Galasko D, Farlow MR, Lucey BP, Honig LS, Elbert D, Bateman R, Momper J, Thomas RG, Rissman RA, Pa J, Aslanyan V, Balasubramanian A, West T, Maccecchini M, Feldman HH. PMID: 38970127; PMCID: PMC11225352.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    24. Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease. Alzheimers Dement. 2024 08; 20(8):5236-5246. Morales J, Gabriel N, Natarajan L, LaCroix AZ, Shadyab AH, Xu R, Silverman J, Feldman HH, Hernandez I, Powder for Pennies Collaboration. PMID: 39030734; PMCID: PMC11350022.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Alzheimer-Type Cerebral Amyloidosis in the Context of HIV Infection: Implications for a Proposed New Treatment Approach. J Neuroimmune Pharmacol. 2024 Jun 03; 19(1):27. Ellis RJ, Pal S, Achim CL, Sundermann E, Moore DJ, Soontornniyomkij V, Feldman H. PMID: 38829507; PMCID: PMC11147830.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam). PLoS One. 2024; 19(5):e0302998. Feldman HH, Luchsinger JA, Léger GC, Taylor C, Jacobs DM, Salmon DP, Edland SD, Messer K, Revta C, Flowers SA, Jones KS, Koulman A, Yarasheski KE, Verghese PB, Venkatesh V, Zetterberg H, Durant J, Lupo JL, Gibson GE, ADCS BenfoTeam Study Group. PMID: 38809849; PMCID: PMC11135745.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    27. Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective. Alzheimers Dement (N Y). 2024 Apr-Jun; 10(2):e12463. Patel KJ, Yang D, Feldman HH, Hsiung GR, Nygaard HB, Best JR, Dwosh E, Robillard JM, DeMarco ML. PMID: 38596482; PMCID: PMC10999946.
      View in: PubMed   Mentions: 7  
    28. Clinical value of Alzheimer's disease biomarker testing. Alzheimers Dement (N Y). 2024 Apr-Jun; 10(2):e12464. Patel KJ, Yang D, Best JR, Chambers C, Lee PE, Henri-Bhargava A, Funnell CR, Foti DJ, Pettersen JA, Feldman HH, Nygaard HB, Hsiung GR, DeMarco ML. PMID: 38596484; PMCID: PMC10999950.
      View in: PubMed   Mentions: 2  
    29. A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with Early Alzheimer's Disease. medRxiv. 2024 Mar 22. Galasko D, Farlow MR, Lucey BP, Honig LS, Elbert D, Bateman R, Momper J, Thomas R, Rissman RA, Pa J, Aslanyan V, Balasubramanian A, West T, Maccecchini M, Feldman HH. PMID: 38562783; PMCID: PMC10984053.
      View in: PubMed   Mentions:
    30. Developing the Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia program. Alzheimers Dement (N Y). 2024 Jan-Mar; 10(1):e12457. Moukarzel S, Zlatar ZZ, Hartman SJ, Lomas D, Feldman HH, Banks SJ, HALT-AD Study Group. PMID: 38440783; PMCID: PMC10909928.
      View in: PubMed   Mentions: 2  
    31. Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians. Alzheimers Dement. 2024 03; 20(3):2058-2071. Ho PC, Yu WH, Tee BL, Lee WP, Li C, Gu Y, Yokoyama JS, Reyes-Dumeyer D, Choi YB, Yang HS, Vardarajan BN, Tzuang M, Lieu K, Lu A, Faber KM, Potter ZD, Revta C, Kirsch M, McCallum J, Mei D, Booth B, Cantwell LB, Chen F, Chou S, Clark D, Deng M, Hong TH, Hwang LJ, Jiang L, Joo Y, Kang Y, Kim ES, Kim H, Kim K, Kuzma AB, Lam E, Lanata SC, Lee K, Li D, Li M, Li X, Liu CL, Liu C, Liu L, Lupo JL, Nguyen K, Pfleuger SE, Qian J, Qian W, Ramirez V, Russ KA, Seo EH, Song YE, Tartaglia MC, Tian L, Torres M, Vo N, Wong EC, Xie Y, Yau EB, Yi I, Yu V, Zeng X, St George-Hyslop P, Au R, Schellenberg GD, Dage JL, Varma R, Hsiung GR, Rosen H, Henderson VW, Foroud T, Kukull WA, Peavy GM, Lee H, Feldman HH, Mayeux R, Chui H, Jun GR, Ta Park VM, Chow TW, Wang LS. PMID: 38215053; PMCID: PMC10984480.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    32. Varoglutamstat: Inhibiting Glutaminyl Cyclase as a Novel Target of Therapy in Early Alzheimer's Disease. J Alzheimers Dis. 2024; 101(s1):S79-S93. Feldman HH, Messer K, Qiu Y, Sabbagh M, Galasko D, Turner RS, Lopez O, Smith A, Durant J, Lupo JL, Revta C, Balasubramanian A, Kuehn-Wache K, Wassmann T, Schell-Mader S, Jacobs DM, Salmon DP, Léger G, DeMarco ML, Weber F, ADCS VIVA-MIND Study Group. PMID: 39422941; PMCID: PMC11494639.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    33. Efficacy assessment of an active tau immunotherapy in Alzheimer's disease patients with amyloid and tau pathology: a post hoc analysis of the "ADAMANT" randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trial. EBioMedicine. 2024 Jan; 99:104923. Cullen NC, Novak P, Tosun D, Kovacech B, Hanes J, Kontsekova E, Fresser M, Ropele S, Feldman HH, Schmidt R, Winblad B, Zilka N. PMID: 38101301; PMCID: PMC10733085.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    34. Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease. Front Pharmacol. 2023; 14:1190402. Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. PMID: 37601062; PMCID: PMC10436590.
      View in: PubMed   Mentions: 10  
    35. Optimal Weighting of Preclinical Alzheimer's Cognitive Composite (PACC) Scales to Improve their Performance as Outcome Measures for Alzheimer's Disease Clinical Trials. Int J Stat Med Res. 2023 Feb 15; 12:90-96. Wang X, Jacobs D, Salmon DP, Feldman HH, Edland SD. PMID: 38487620; PMCID: PMC10939003.
      View in: PubMed   Mentions: 1  
    36. Protocol for the Brain Health Support Program Study of the Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP): A Prospective 12-Month Intervention Study. J Prev Alzheimers Dis. 2023; 10(4):875-885. Feldman HH, Belleville S, Nygaard HB, Montero-Odasso M, Durant J, Lupo JL, Revta C, Chan S, Cuesta M, Slack PJ, Winer S, Brewster PWH, Hofer SM, Lim A, Centen A, Jacobs DM, Anderson ND, Walker JD, Speechley MR, Zou GY, Chertkow H. PMID: 37874110; PMCID: PMC10258470.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    37. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimers Dement. 2023 03; 19(3):1041-1066. Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL. PMID: 36479795; PMCID: PMC10576546.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    38. RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia-an international Delphi consensus. Alzheimers Res Ther. 2022 11 11; 14(1):169. O'Brien JT, Chouliaras L, Sultana J, Taylor JP, Ballard C, RENEWAL Study Group. PMID: 36369100; PMCID: PMC9650797.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease. Front Med (Lausanne). 2022; 9:1033272. Gibson GE, Feldman HH, Zhang S, Flowers SA, Luchsinger JA. PMID: 36275801; PMCID: PMC9585656.
      View in: PubMed   Mentions: 12  
    40. Exploring Social Cognition Tests to Differentiate Frontotemporal Dementia from Depression: A Two-Step Pilot Study. Alzheimer Dis Assoc Disord. 2023 Apr-Jun 01; 37(2):145-148. Lichtenstein ML, Stewart PV, Kirchner HL, Finney G, Feldman HH. PMID: 36030814; PMCID: PMC10219668.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Home EEG sleep assessment shows reduced slow-wave sleep in mild-moderate Alzheimer's disease. Alzheimers Dement (N Y). 2022; 8(1):e12347. Kent BA, Casciola AA, Carlucci SK, Chen M, Stager S, Mirian MS, Slack P, Valerio J, McKeown MJ, Feldman HH, Nygaard HB. PMID: 35992215; PMCID: PMC9381912.
      View in: PubMed   Mentions: 6  
    42. Multidomain trials to prevent dementia: addressing methodological challenges. Alzheimers Res Ther. 2022 07 11; 14(1):94. Montero-Odasso M, Zou GY, Kamkar N, Feldman HH, Belleville S, Chertkow H, Nygaard HB, Son S, Speechley M. PMID: 35820915; PMCID: PMC9275261.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. CMS coverage decision on anti-amyloid monoclonal antibodies for Alzheimer disease. Nat Rev Neurol. 2022 07; 18(7):379-380. Knopman D, Sano M, Feldman HH. PMID: 35596071.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. A Matter for Life and Death: Managing Psychological Trauma in Care Homes. J Am Med Dir Assoc. 2022 07; 23(7):1123-1126. Estabrooks CA, Titley HK, Thorne T, Banerjee S, Feldman HH, Silvius J, Lanius RA. PMID: 35788266.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial. JAMA Neurol. 2022 06 01; 79(6):565-574. Rafii MS, Sol O, Mobley WC, Delpretti S, Skotko BG, Burke AD, Sabbagh MN, Yuan SH, Rissman RA, Pulsifer M, Evans C, Evans AC, Beth G, Fournier N, Gray JA, Dos Santos AM, Hliva V, Vukicevic M, Kosco-Vilbois M, Streffer J, Pfeifer A, Feldman HH. PMID: 35532913; PMCID: PMC9086937.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    46. T2 Protect AD: Achieving a rapid recruitment timeline in a multisite clinical trial for individuals with mild to moderate Alzheimer's disease. Alzheimers Dement (N Y). 2022; 8(1):e12265. Shadyab AH, LaCroix AZ, Matthews G, Bennett D, Shadyab AA, Tan D, Thomas RG, Mason J, Lopez A, Askew B, Donahue L, Kaplita S, Qureshi IA, Huisa B, Feldman HH, Alzheimer's Disease Cooperative Study T2 Protect AD Study Group. PMID: 35310528; PMCID: PMC8919121.
      View in: PubMed   Mentions: 2  
    47. Impact of potential modifications to Alzheimer's disease clinical trials in response to disruption by COVID-19: a simulation study. Alzheimers Res Ther. 2021 12 20; 13(1):201. Schneider LS, Qiu Y, Thomas RG, Evans C, Jacobs DM, Jin S, Kaye JA, LaCroix AZ, Messer K, Salmon DP, Sano M, Schafer K, Feldman HH. PMID: 34930444; PMCID: PMC8686345.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    48. Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab. Can Geriatr J. 2021 Dec; 24(4):373-378. Chertkow H, Rockwood K, Hogan DB, Phillips N, Montero-Odasso M, Amanullah S, Black S, Bocti C, Borrie M, Feldman H, Freedman M, Hsiung R, Kirk A, Masellis M, Nygaard H, Rajji T, Verret L. PMID: 34912492; PMCID: PMC8629494.
      View in: PubMed   Mentions: 4  
    49. Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report. Alzheimers Dement. 2022 06; 18(6):1109-1118. Jicha GA, Abner EL, Arnold SE, Carrillo MC, Dodge HH, Edland SD, Fargo KN, Feldman HH, Goldstein LB, Hendrix J, Peters R, Robillard JM, Schneider LS, Titiner JR, Weber CJ, Clinical Trial Advancement & Methodology Professional Interest Area of the International Society to . PMID: 34590417; PMCID: PMC8960469.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    50. Current directions in tau research: Highlights from Tau 2020. Alzheimers Dement. 2022 05; 18(5):988-1007. Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion JP, Buée L, Cacace AM, Chételat G, Citron M, DeVos SL, Diaz K, Feldman HH, Frost B, Goate AM, Gold M, Hyman B, Johnson K, Karch CM, Kerwin DR, Koroshetz WJ, Litvan I, Morris HR, Mummery CJ, Mutamba J, Patterson MC, Quiroz YT, Rabinovici GD, Rommel A, Shulman MB, Toledo-Sherman LM, Weninger S, Wildsmith KR, Worley SL, Carrillo MC. PMID: 34581500.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    51. Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial. Alzheimers Dement. 2021 11; 17(11):1808-1817. Shadyab AH, LaCroix AZ, Feldman HH, van Dyck CH, Okonkwo OC, Tam SP, Fairchild JK, Welsh-Bohmer KA, Matthews G, Bennett D, Shadyab AA, Schafer KA, Morrison RH, Kipperman SA, Mason J, Tan D, Thomas RG, Cotman CW, Baker LD, ADCS EXERT Study Group. PMID: 34297895; PMCID: PMC9292825.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    52. Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group. Lancet Neurol. 2021 06; 20(6):484-496. Dubois B, Villain N, Frisoni GB, Rabinovici GD, Sabbagh M, Cappa S, Bejanin A, Bombois S, Epelbaum S, Teichmann M, Habert MO, Nordberg A, Blennow K, Galasko D, Stern Y, Rowe CC, Salloway S, Schneider LS, Cummings JL, Feldman HH. PMID: 33933186; PMCID: PMC8339877.
      View in: PubMed   Mentions: 416     Fields:    Translation:Humans
    53. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. J Clin Med. 2021 Apr 28; 10(9). Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, Hart S, Haugen K, Head E, Hendrix S, Hillerstrom H, Kishnani PS, Krell K, Ledesma DL, Lai F, Lott I, Ochoa-Lubinoff C, Mason J, Nicodemus-Johnson J, Proctor NK, Pulsifer MB, Revta C, Rosas HD, Rosser TC, Santoro S, Schafer K, Scheidemantel T, Schmitt F, Skotko BG, Stasko MR, Talboy A, Torres A, Wilmes K, Woodward J, Zimmer JA, Feldman HH, Mobley W. PMID: 33924960; PMCID: PMC8124643.
      View in: PubMed   Mentions: 20  
    54. Value-Generating Exploratory Trials in Neurodegenerative Dementias. Neurology. 2021 05 18; 96(20):944-954. Friedman LG, McKeehan N, Hara Y, Cummings JL, Matthews DC, Zhu J, Mohs RC, Wang D, Hendrix SB, Quintana M, Schneider LS, Grundman M, Dickson SP, Feldman HH, Jaeger J, Finger EC, Ryan JM, Niehoff D, Dickinson SL, Markowitz JT, Owen M, Travaglia A, Fillit HM. PMID: 33674360; PMCID: PMC8205472.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    55. Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia. Alzheimers Dement (N Y). 2021; 7(1):e12106. Matthews DC, Ritter A, Thomas RG, Andrews RD, Lukic AS, Revta C, Kinney JW, Tousi B, Leverenz JB, Fillit H, Zhong K, Feldman HH, Cummings J. PMID: 33614888; PMCID: PMC7882538.
      View in: PubMed   Mentions: 26  
    56. Brain volumetric deficits in MAPT mutation carriers: a multisite study. Ann Clin Transl Neurol. 2021 01; 8(1):95-110. Chu SA, Flagan TM, Staffaroni AM, Jiskoot LC, Deng J, Spina S, Zhang L, Sturm VE, Yokoyama JS, Seeley WW, Papma JM, Geschwind DH, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Forsberg LK, Brushaber DE, Grossman M, Coppola G, Dickerson BC, Bordelon YM, Faber K, Feldman HH, Fields JA, Fong JC, Foroud T, Gavrilova RH, Ghoshal N, Graff-Radford NR, Hsiung GR, Huey ED, Irwin DJ, Kantarci K, Kaufer DI, Karydas AM, Knopman DS, Kornak J, Kramer JH, Kukull WA, Lapid MI, Litvan I, Mackenzie IRA, Mendez MF, Miller BL, Onyike CU, Pantelyat AY, Rademakers R, Marisa Ramos E, Roberson ED, Carmela Tartaglia M, Tatton NA, Toga AW, Vetor A, Weintraub S, Wong B, Wszolek ZK, ARTFL/LEFFTDS Consortium, Van Swieten JC, Lee SE. PMID: 33247623; PMCID: PMC7818091.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    57. Applying the Alzheimer Disease ATN Diagnostic Framework in Atypical Dementia. Alzheimer Dis Assoc Disord. 2020 Oct-Dec; 34(4):357-359. Funnell C, Feldman HH, Mackenzie IRA, DeMarco ML. PMID: 33215886.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    58. Enriching the design of Alzheimer's disease clinical trials: Application of the polygenic hazard score and composite outcome measures. Alzheimers Dement (N Y). 2020; 6(1):e12071. Banks SJ, Qiu Y, Fan CC, Dale AM, Zou J, Askew B, Feldman HH, Alzheimer's Disease Neuroimaging Initiative. PMID: 32999917; PMCID: PMC7507583.
      View in: PubMed   Mentions: 9  
    59. Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS-Cog-Exec. Alzheimers Dement (N Y). 2020; 6(1):e12059. Jacobs DM, Thomas RG, Salmon DP, Jin S, Feldman HH, Cotman CW, Baker LD, Alzheimer's Disease Cooperative Study EXERT Study Group, Alzheimer's Disease Neuroimaging Initiative. PMID: 32995469; PMCID: PMC7507362.
      View in: PubMed   Mentions: 13  
    60. Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults. Neurology. 2020 10 20; 95(16):e2295-e2304. Weigand AJ, Bondi MW, Thomas KR, Campbell NL, Galasko DR, Salmon DP, Sewell D, Brewer JB, Feldman HH, Delano-Wood L, Alzheimer's Disease Neuroimaging Initiative. PMID: 32878992; PMCID: PMC7713781.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    61. Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer's disease. Prog Neurobiol. 2021 02; 197:101902. Kent BA, Feldman HH, Nygaard HB. PMID: 32877742; PMCID: PMC7855222.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    62. World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020 07; 16(7):1078-1094. Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas RM, Scheltens P, Sevlever G, Soininen H, Sosa AL, Suemoto CK, Tainta-Cuezva M, Velilla L, Wang Y, Whitmer R, Whitmer R, Xu X, Bain LJ, Solomon A, Ngandu T, Carrillo MC. PMID: 32627328; PMCID: PMC9527644.
      View in: PubMed   Mentions: 251     Fields:    Translation:Humans
    63. Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS). J Neuropathol Exp Neurol. 2020 07 01; 79(7):809-812. Chornenka K, Hirsch-Reinshagen V, Perez-Rosendahl M, Feldman H, Segal-Gidan F, Vinters HV, Mackenzie IR. PMID: 32483606.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    64. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 03 16; 15(1):21. Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, Roberge M, Nygaard HB. PMID: 32178712; PMCID: PMC7075020.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    65. New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Alzheimers Dement. 2020 01; 16(1):131-143. Boxer AL, Gold M, Feldman H, Boeve BF, Dickinson SL, Fillit H, Ho C, Paul R, Pearlman R, Sutherland M, Verma A, Arneric SP, Alexander BM, Dickerson BC, Dorsey ER, Grossman M, Huey ED, Irizarry MC, Marks WJ, Masellis M, McFarland F, Niehoff D, Onyike CU, Paganoni S, Panzara MA, Rockwood K, Rohrer JD, Rosen H, Schuck RN, Soares HD, Tatton N. PMID: 31668596; PMCID: PMC6949386.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    66. Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation. Stem Cell Res. 2019 12; 41:101582. Frew J, Wu X, Hsiung GY, Feldman HH, Mackenzie IR, Nygaard HB. PMID: 31707213.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    67. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2019 Nov 01; 76(11):1330-1339. Schneider LS, Thomas RG, Hendrix S, Rissman RA, Brewer JB, Salmon DP, Oltersdorf T, Okuda T, Feldman HH, Alzheimer’s Disease Cooperative Study TCAD Study Group. PMID: 31282954; PMCID: PMC6618817.
      View in: PubMed   Mentions: 16     Fields:    
    68. The "rights" of precision drug development for Alzheimer's disease. Alzheimers Res Ther. 2019 08 31; 11(1):76. Cummings J, Feldman HH, Scheltens P. PMID: 31470905; PMCID: PMC6717388.
      View in: PubMed   Mentions: 117     Fields:    Translation:Humans
    69. Cognitive heterogeneity in probable Alzheimer disease: Clinical and neuropathologic features. Neurology. 2019 08 20; 93(8):e778-e790. Qiu Y, Jacobs DM, Messer K, Salmon DP, Feldman HH. PMID: 31320469; PMCID: PMC6711663.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    70. The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study. Can J Neurol Sci. 2019 09; 46(5):499-511. Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Camicioli R, Smith EE, Fogarty J, Lindsay J, Best S, Evans A, Das S, Mohaddes Z, Pilon R, Poirier J, Phillips NA, MacNamara E, Dixon RA, Duchesne S, MacKenzie I, Rylett RJ. PMID: 31309917.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    71. A randomized clinical trial to evaluate home-based assessment of people over 75 years old. Alzheimers Dement. 2019 05; 15(5):615-624. Sano M, Zhu CW, Kaye J, Mundt JC, Hayes TL, Ferris S, Thomas RG, Sun CK, Jiang Y, Donohue MC, Schneider LS, Egelko S, Aisen PS, Feldman HH, Alzheimer Disease Cooperative Study Investigators. PMID: 30872114.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    72. Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neurobiol Aging. 2019 06; 78:74-86. Kent BA, Michalik M, Marchant EG, Yau KW, Feldman HH, Mistlberger RE, Nygaard HB. PMID: 30884411.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    73. Memantine and Acetylcholinesterase Inhibitor Use in Alzheimer's Disease Clinical Trials: Potential for Confounding by Indication. J Alzheimers Dis. 2019; 67(2):707-713. Huisa BN, Thomas RG, Jin S, Oltersdorf T, Taylor C, Feldman HH. PMID: 30636733.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    74. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. PMID: 30413934; PMCID: PMC6358498.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    75. Therapeutic trial design for frontotemporal dementia and related disorders. J Neurol Neurosurg Psychiatry. 2019 04; 90(4):412-423. Desmarais P, Rohrer JD, Nguyen QD, Herrmann N, Stuss DT, Lang AE, Boxer AL, Dickerson BC, Rosen H, van Swieten JC, Meeter LH, Borroni B, Tartaglia MC, Feldman HH, Black SE, Masellis M. PMID: 30361298.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    76. Participant satisfaction with dementia prevention research: Results from Home-Based Assessment trial. Alzheimers Dement. 2018 11; 14(11):1397-1405. Sano M, Egelko S, Zhu CW, Li C, Donohue MC, Ferris S, Kaye J, Mundt JC, Sun CK, Aisen PS, Feldman HH. PMID: 30297140.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    77. Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY). Alzheimers Res Ther. 2018 09 27; 10(1):102. Finger E, Berry S, Cummings J, Coleman K, Hsiung R, Feldman HH, Boxer A. PMID: 30261917; PMCID: PMC6161323.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    78. 16-Year Survival of the Canadian Collaborative Cohort of Related Dementias. Can J Neurol Sci. 2018 07; 45(4):367-374. Lichtenstein ML, Fallah N, Mudge B, Hsiung GR, Foti D, Beattie BL, Feldman HH. PMID: 29730995.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    79. Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers. Neuroimage Clin. 2018; 18:591-598. Popuri K, Dowds E, Beg MF, Balachandar R, Bhalla M, Jacova C, Buller A, Slack P, Sengdy P, Rademakers R, Wittenberg D, Feldman HH, Mackenzie IR, Hsiung GR. PMID: 29845007; PMCID: PMC5964622.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    80. Neurobehavioral characterization of adult-onset Alexander disease: A family study. Neurol Clin Pract. 2017 Oct; 7(5):425-429. Lichtenstein ML, Dwosh E, Roy Chowdhury A, Farrer MJ, McKenzie MB, Guella I, Evans DM, Nygaard HB, Shewchuk JR, Hayden S, Barton JJS, Feldman HH. PMID: 29620072; PMCID: PMC5874457.
      View in: PubMed   Mentions: 4  
    81. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017 Jul 04; 89(1):88-100. McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K. PMID: 28592453; PMCID: PMC5496518.
      View in: PubMed   Mentions: 1847     Fields:    Translation:Humans
    82. The Canadian dementia challenge: Ensuring optimal care and services for those at risk or with dementia throughout the country. Can J Public Health. 2017 04 20; 108(1):e95-e97. Feldman HH, Estabrooks CA. PMID: 28425906; PMCID: PMC6975213.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    83. The 2002 NIMH Provisional Diagnostic Criteria for Depression of Alzheimer's Disease (PDC-dAD): Gauging their Validity over a Decade Later. J Alzheimers Dis. 2017; 58(2):449-462. Sepehry AA, Lee PE, Hsiung GR, Beattie BL, Feldman HH, Jacova C. PMID: 28453472.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    84. Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. Lancet. 2016 12 10; 388(10062):2873-2884. Gauthier S, Feldman HH, Schneider LS, Wilcock GK, Frisoni GB, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Wischik DJ, Schelter BO, Davis CS, Staff RT, Bracoud L, Shamsi K, Storey JM, Harrington CR, Wischik CM. PMID: 27863809; PMCID: PMC5164296.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCTClinical Trials
    85. A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology. 2016 Aug 02; 87(5):539-47. Jack CR, Bennett DA, Blennow K, Carrillo MC, Feldman HH, Frisoni GB, Hampel H, Jagust WJ, Johnson KA, Knopman DS, Petersen RC, Scheltens P, Sperling RA, Dubois B. PMID: 27371494; PMCID: PMC4970664.
      View in: PubMed   Mentions: 937     Fields:    Translation:Humans
    86. Defeating Alzheimer's disease and other dementias: a priority for European science and society. Lancet Neurol. 2016 Apr; 15(5):455-532. Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H. PMID: 26987701.
      View in: PubMed   Mentions: 691     Fields:    Translation:Humans
    87. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016 Mar; 12(3):292-323. Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, O'Bryant SE, Rabinovici GD, Rowe C, Salloway S, Schneider LS, Sperling R, Teichmann M, Carrillo MC, Cummings J, Jack CR, Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Ass. PMID: 27012484; PMCID: PMC6417794.
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    88. Periventricular hyperintensities are associated with elevated cerebral amyloid. Neurology. 2016 Feb 09; 86(6):535-43. Marnane M, Al-Jawadi OO, Mortazavi S, Pogorzelec KJ, Wang BW, Feldman HH, Hsiung GY, Alzheimer's Disease Neuroimaging Initiative. PMID: 26747881; PMCID: PMC4753726.
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    89. Effect of diesel exhaust inhalation on blood markers of inflammation and neurotoxicity: a controlled, blinded crossover study. Inhal Toxicol. 2016; 28(3):145-53. Cliff R, Curran J, Hirota JA, Brauer M, Feldman H, Carlsten C. PMID: 26915823.
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    90. Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial. JAMA Neurol. 2015 Nov; 72(11):1324-33. Coric V, Salloway S, van Dyck CH, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Pilcher G, Ferris S, Colby S, Kerselaers W, Dockens R, Soares H, Kaplita S, Luo F, Pachai C, Bracoud L, Mintun M, Grill JD, Marek K, Seibyl J, Cedarbaum JM, Albright C, Feldman HH, Berman RM. PMID: 26414022.
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    91. Early neuropsychological characteristics of progranulin mutation carriers. J Int Neuropsychol Soc. 2014 Aug; 20(7):694-703. Hallam BJ, Jacova C, Hsiung GY, Wittenberg D, Sengdy P, Bouchard-Kerr P, Slack P, Rademakers R, Baker M, Chow TW, Levine B, Feldman HH, Mackenzie IR. PMID: 24993774.
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    92. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014 Jun; 13(6):614-29. Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL. PMID: 24849862.
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    93. Alzheimer's disease research and development: a call for a new research roadmap. Ann N Y Acad Sci. 2014 Apr; 1313:1-16. Feldman HH, Haas M, Gandy S, Schoepp DD, Cross AJ, Mayeux R, Sperling RA, Fillit H, van de Hoef DL, Dougal S, Nye JS, One Mind for Research and the New York Academy of Sciences. PMID: 24754377.
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    94. Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population. Neurobiol Aging. 2014 Apr; 35(4):936.e5-12. Omoumi A, Fok A, Greenwood T, Sadovnick AD, Feldman HH, Hsiung GY. PMID: 24176626.
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    95. Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers. Neurology. 2013 Oct 08; 81(15):1322-31. Jacova C, Hsiung GY, Tawankanjanachot I, Dinelle K, McCormick S, Gonzalez M, Lee H, Sengdy P, Bouchard-Kerr P, Baker M, Rademakers R, Sossi V, Stoessl AJ, Feldman HH, Mackenzie IR. PMID: 24005336; PMCID: PMC3806924.
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    96. Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia. Alzheimers Res Ther. 2013 Jul 08; 5(Suppl 1):S2. Chertkow H, Feldman HH, Jacova C, Massoud F. PMID: 24565215; PMCID: PMC3981054.
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    97. Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimers Dement. 2013 Mar; 9(2):123-131.e1. Carrillo MC, Brashear HR, Logovinsky V, Ryan JM, Feldman HH, Siemers ER, Abushakra S, Hartley DM, Petersen RC, Khachaturian AS, Sperling RA. PMID: 23411394.
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    98. A conceptual framework and ethics analysis for prevention trials of Alzheimer Disease. Prog Neurobiol. 2013 Nov; 110:114-23. Peters KR, Lynn Beattie B, Feldman HH, Illes J. PMID: 23348495.
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    99. Pharmacodynamics of selective inhibition of γ-secretase by avagacestat. J Pharmacol Exp Ther. 2013 Mar; 344(3):686-95. Albright CF, Dockens RC, Meredith JE, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, Polson C, Guss V, White R, Simutis F, Sanderson T, Gillman KW, Starrett JE, Bronson J, Sverdlov O, Huang SP, Castaneda L, Feldman H, Coric V, Zaczek R, Macor JE, Houston J, Berman RM, Tong G. PMID: 23275065.
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    100. Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease. Arch Neurol. 2012 Nov; 69(11):1430-40. Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M, Richter RW, Soininen H, Thein S, Shiovitz T, Pilcher G, Colby S, Rollin L, Dockens R, Pachai C, Portelius E, Andreasson U, Blennow K, Soares H, Albright C, Feldman HH, Berman RM. PMID: 22892585.
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    101. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98. Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. PMID: 23062850; PMCID: PMC3562382.
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    102. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement. 2013 Mar; 9(2):176-88. Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J. PMID: 23043900; PMCID: PMC3542408.
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    103. Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p. Brain. 2012 Mar; 135(Pt 3):709-22. Hsiung GY, DeJesus-Hernandez M, Feldman HH, Sengdy P, Bouchard-Kerr P, Dwosh E, Butler R, Leung B, Fok A, Rutherford NJ, Baker M, Rademakers R, Mackenzie IR. PMID: 22344582; PMCID: PMC3286328.
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    104. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3985-90. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM, Alzheimer's Disease Neuroimaging Initiative, Pediatric Imaging, Neurocognition, and Genetics Study, Weiner M, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Liu E, Montine T, Gamst A, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Harvey D, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe RA, Foster N, Reiman EM, Chen K, Mathis C, Cairns NJ, Taylor-Reinwald L, Trojanowki JQ, Shaw L, Lee VM, Korecka M, Crawford K, Neu S, Foroud TM, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder PJ, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider LS, Pawluczyk S, Spann BM, Brewer J, Vanderswag H, Heidebrink JL, Lord JL, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig LS, Bell KL, Morris JC, Ances B, Carroll M, Leon S, Mintun MA, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah RC, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon MJ, Glodzik L, De Santi S, Doraiswamy PM, Petrella JR, Coleman RE, Arnold SE, Karlawish JH, Wolk D, Smith CD, Jicha G, Hardy P, Lopez OL, Oakley M, Simpson DM, Porsteinsson AP, Goldstein BS, Martin K, Makino KM, Ismail MS, Brand C, Mulnard RA, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Swerdlow RH, Apostolova L, Lu PH, Bartzokis G, Silverman DH, Graff-Radford NR, Parfitt F, Johnson H, Farlow MR, Hake AM, Matthews BR, Herring S, van Dyck CH, Carson RE, MacAvoy MG, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung R, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam MM, Lipowski K, Wu CK, Johnson N, Sadowsky C, Martinez W, Villena T, Turner RS, Johnson K, Reynolds B, Sperling RA, Johnson KA, Marshall G, Frey M, Yesavage J, Taylor JL, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson AE, Norbash A, Johnson PL, Obisesan TO, Wolday S, Bwayo SK, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, et al. PMID: 22343285; PMCID: PMC3309762.
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    105. Synaptic dysfunction in progranulin-deficient mice. Neurobiol Dis. 2012 Feb; 45(2):711-22. Petkau TL, Neal SJ, Milnerwood A, Mew A, Hill AM, Orban P, Gregg J, Lu G, Feldman HH, Mackenzie IR, Raymond LA, Leavitt BR. PMID: 22062772.
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    106. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 2011 Oct 20; 72(2):245-56. DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R. PMID: 21944778; PMCID: PMC3202986.
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    107. Prevention trials in Alzheimer's disease: an EU-US task force report. Prog Neurobiol. 2011 Dec; 95(4):594-600. Vellas B, Aisen PS, Sampaio C, Carrillo M, Scheltens P, Scherrer B, Frisoni GB, Weiner M, Schneider L, Gauthier S, Gispen-de Wied CC, Hendrix S, Feldman H, Cedarbaum J, Petersen R, Siemers E, Andrieu S, Prvulovic D, Touchon J, Hampel H. PMID: 21925234.
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    108. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement. 2011 Jul; 7(4):367-85. Sperling RA, Jack CR, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, Schindler RJ. PMID: 21784348; PMCID: PMC3693547.
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    109. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May; 7(3):270-9. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. PMID: 21514249; PMCID: PMC3312027.
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    110. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Arch Neurol. 2011 Apr; 68(4):488-97. Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, Brooks WS, Halliday GM, Kril JJ, Gearing M, Beach TG, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Pickering-Brown SM, Snowden J, van Swieten JC, Heutink P, Seelaar H, Murrell JR, Ghetti B, Spina S, Grafman J, Kaye JA, Woltjer RL, Mesulam M, Bigio E, Lladó A, Miller BL, Alzualde A, Moreno F, Rohrer JD, Mackenzie IR, Feldman HH, Hamilton RL, Cruts M, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bird TD, Cairns NJ, Goate A, Frosch MP, Riederer PF, Bogdanovic N, Lee VM, Trojanowski JQ, Van Deerlin VM. PMID: 21482928; PMCID: PMC3160280.
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    111. Global issues in drug development for Alzheimer's disease. Alzheimers Dement. 2011 Mar; 7(2):197-207. Doody RS, Cole PE, Miller DS, Siemers E, Black R, Feldman H, Schindler R, Graham S, Heath T, Khachaturian AS, Evans R, Carrillo MC. PMID: 21414556.
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    112. Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance. Neurobiol Aging. 2012 Jul; 33(7):1203-14. Ewers M, Walsh C, Trojanowski JQ, Shaw LM, Petersen RC, Jack CR, Feldman HH, Bokde AL, Alexander GE, Scheltens P, Vellas B, Dubois B, Weiner M, Hampel H, North American Alzheimer's Disease Neuroimaging Initiative (ADNI). PMID: 21159408; PMCID: PMC3328615.
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    113. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010 Nov 18; 68(4):654-67. Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A, Strittmatter SM. PMID: 21092856; PMCID: PMC2990962.
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    114. rs5848 polymorphism and serum progranulin level. J Neurol Sci. 2011 Jan 15; 300(1-2):28-32. Hsiung GY, Fok A, Feldman HH, Rademakers R, Mackenzie IR. PMID: 21047645; PMCID: PMC3085023.
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    115. Dependence as a unifying construct in defining Alzheimer's disease severity. Alzheimers Dement. 2010 Nov; 6(6):482-93. McLaughlin T, Feldman H, Fillit H, Sano M, Schmitt F, Aisen P, Leibman C, Mucha L, Ryan JM, Sullivan SD, Spackman DE, Neumann PJ, Cohen J, Stern Y. PMID: 21044778; PMCID: PMC3884683.
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    116. Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol. 2010 Nov; 9(11):1118-27. Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P, Delacourte A, Frisoni G, Fox NC, Galasko D, Gauthier S, Hampel H, Jicha GA, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Sarazin M, de Souza LC, Stern Y, Visser PJ, Scheltens P. PMID: 20934914.
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    117. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010; 30(2):161-78. Olazarán J, Reisberg B, Clare L, Cruz I, Peña-Casanova J, Del Ser T, Woods B, Beck C, Auer S, Lai C, Spector A, Fazio S, Bond J, Kivipelto M, Brodaty H, Rojo JM, Collins H, Teri L, Mittelman M, Orrell M, Feldman HH, Muñiz R. PMID: 20838046.
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    118. Differentiating the frontal variant of Alzheimer's disease. Int J Geriatr Psychiatry. 2010 Jul; 25(7):732-8. Woodward M, Jacova C, Black SE, Kertesz A, Mackenzie IR, Feldman H, ACCORD investigator group. PMID: 19823987.
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    119. Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family. J Neurol Neurosurg Psychiatry. 2011 Feb; 82(2):196-203. Boxer AL, Mackenzie IR, Boeve BF, Baker M, Seeley WW, Crook R, Feldman H, Hsiung GY, Rutherford N, Laluz V, Whitwell J, Foti D, McDade E, Molano J, Karydas A, Wojtas A, Goldman J, Mirsky J, Sengdy P, Dearmond S, Miller BL, Rademakers R. PMID: 20562461; PMCID: PMC3017222.
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    120. A novel PS1 gene mutation in a large Aboriginal kindred. Can J Neurol Sci. 2010 May; 37(3):359-64. Butler R, Beattie BL, Thong UP, Dwosh E, Guimond C, Feldman HH, Hsiung GY, Rogaeva E, St George-Hyslop P, Sadovnick AD. PMID: 20481270.
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    121. Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder. Depress Anxiety. 2010 May; 27(5):417-25. Coric V, Feldman HH, Oren DA, Shekhar A, Pultz J, Dockens RC, Wu X, Gentile KA, Huang SP, Emison E, Delmonte T, D'Souza BB, Zimbroff DL, Grebb JA, Goddard AW, Stock EG. PMID: 20455246.
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    122. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3):234-9. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. PMID: 20154673; PMCID: PMC2828525.
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    123. The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Arch Neurol. 2010 Feb; 67(2):161-70. Yu CE, Bird TD, Bekris LM, Montine TJ, Leverenz JB, Steinbart E, Galloway NM, Feldman H, Woltjer R, Miller CA, Wood EM, Grossman M, McCluskey L, Clark CM, Neumann M, Danek A, Galasko DR, Arnold SE, Chen-Plotkin A, Karydas A, Miller BL, Trojanowski JQ, Lee VM, Schellenberg GD, Van Deerlin VM. PMID: 20142524; PMCID: PMC2901991.
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    124. An exploration of cognitive subgroups in Alzheimer's disease. J Int Neuropsychol Soc. 2010 Mar; 16(2):233-43. Davidson JE, Irizarry MC, Bray BC, Wetten S, Galwey N, Gibson R, Borrie M, Delisle R, Feldman HH, Hsiung GY, Fornazzari L, Gauthier S, Guzman D, Loy-English I, Keren R, Kertesz A, George-Hyslop PS, Wherrett J, Monsch AU. PMID: 19958568; PMCID: PMC2903844.
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    125. Executive dysfunction in vascular cognitive impairment in the consortium to investigate vascular impairment of cognition study. J Neurol Sci. 2010 Jan 15; 288(1-2):142-6. Moorhouse P, Song X, Rockwood K, Black S, Kertesz A, Gauthier S, Feldman H, Consortium to investigate vascular impairment of cognition. PMID: 19840883.
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    126. Assessing the validity of deriving clinical dementia rating (CDR) global scores from independently-obtained functional rating scale (FRS) scores in vascular dementia with and without Alzheimer's disease. Int J Geriatr Psychiatry. 2009 Oct; 24(10):1174-6. Lanctôt KL, Hsiung GY, Feldman HH, Masoud ST, Sham L, Herrmann N. PMID: 19768698.
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    127. Rates of cognitive change in Alzheimer disease: observations across a decade of placebo-controlled clinical trials with donepezil. Alzheimer Dis Assoc Disord. 2009 Oct-Dec; 23(4):357-64. Jones RW, Schwam E, Wilkinson D, Waldemar G, Feldman HH, Zhang R, Albert K, Schindler R. PMID: 19561444.
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    128. Effectiveness of donepezil in reducing clinical worsening in patients with mild-to-moderate alzheimer's disease. Dement Geriatr Cogn Disord. 2009; 28(3):244-51. Wilkinson D, Schindler R, Schwam E, Waldemar G, Jones RW, Gauthier S, Lopez OL, Cummings J, Xu Y, Feldman HH. PMID: 19786776; PMCID: PMC3202931.
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    129. Effects of gender on response to treatment with rivastigmine in mild cognitive impairment: A post hoc statistical modeling approach. Gend Med. 2009 Jul; 6(2):345-55. Ferris S, Lane R, Sfikas N, Winblad B, Farlow M, Feldman HH. PMID: 19682661.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    130. Treatment with galantamine and time to nursing home placement in Alzheimer's disease patients with and without cerebrovascular disease. Int J Geriatr Psychiatry. 2009 May; 24(5):479-88. Feldman HH, Pirttila T, Dartigues JF, Everitt B, Van Baelen B, Schwalen S, Kavanagh S. PMID: 18985627.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    131. Minimizing misdiagnosis: psychometric criteria for possible or probable memory impairment. Dement Geriatr Cogn Disord. 2009; 27(5):439-50. Brooks BL, Iverson GL, Feldman HH, Holdnack JA. PMID: 19401611.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    132. Therapeutic potential of statins in Alzheimer's disease. J Neurol Sci. 2009 Aug 15; 283(1-2):230-4. Kandiah N, Feldman HH. PMID: 19321181.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    133. Predicting response to acetylcholinesterase inhibitor treatment in Alzheimer disease: has the time come? Nat Clin Pract Neurol. 2009 Mar; 5(3):128-9. Feldman HH, Jacova C. PMID: 19190589.
      View in: PubMed   Mentions:    Fields:    
    134. Pharmacological treatment in moderate-to-severe Alzheimer's disease. Expert Opin Pharmacother. 2008 Oct; 9(15):2575-82. Hsiung GY, Feldman HH. PMID: 18803446.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    135. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet. 2008 Dec 01; 17(23):3631-42. Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, Wszolek ZK, Uitti RJ, Feldman H, Hutton ML, Mackenzie IR, Graff-Radford NR, Dickson DW. PMID: 18723524; PMCID: PMC2581433.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    136. Revised research diagnostic criteria for Alzheimer's disease. Lancet Neurol. 2008 Aug; 7(8):668-70. Gauthier S, Dubois B, Feldman H, Scheltens P. PMID: 18635012.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    137. Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease. Stroke. 2008 Oct; 39(10):2894-7. Feldman HH, Maia LF, Mackenzie IR, Forster BB, Martzke J, Woolfenden A. PMID: 18635858.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    138. Potential for misclassification of mild cognitive impairment: a study of memory scores on the Wechsler Memory Scale-III in healthy older adults. J Int Neuropsychol Soc. 2008 May; 14(3):463-78. Brooks BL, Iverson GL, Holdnack JA, Feldman HH. PMID: 18419845.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    139. Transition from cognitively impaired not demented to Alzheimer's disease: an analysis of changes in functional abilities in a dementia clinic cohort. Dement Geriatr Cogn Disord. 2008; 25(6):483-90. Hsiung GY, Alipour S, Jacova C, Grand J, Gauthier S, Black SE, Bouchard RW, Kertesz A, Loy-English I, Hogan DB, Rockwood K, Feldman HH. PMID: 18417973.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    140. Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease. Pharmacogenet Genomics. 2008 Apr; 18(4):289-98. Lane R, Feldman HH, Meyer J, He Y, Ferris SH, Nordberg A, Darreh-Shori T, Soininen H, Pirttilä T, Farlow MR, Sfikas N, Ballard C, Greig NH. PMID: 18334913.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    141. Diagnosis and treatment of dementia: 2. Diagnosis. CMAJ. 2008 Mar 25; 178(7):825-36. Feldman HH, Jacova C, Robillard A, Garcia A, Chow T, Borrie M, Schipper HM, Blair M, Kertesz A, Chertkow H. PMID: 18362376; PMCID: PMC2267847.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    142. The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics. Alzheimers Dement. 2008 Mar; 4(2):145-53. Jones RW, Kivipelto M, Feldman H, Sparks L, Doody R, Waters DD, Hey-Hadavi J, Breazna A, Schindler RJ, Ramos H, LEADe investigators. PMID: 18631958.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    143. Early identification of Alzheimer's disease: what have we learned from mild cognitive impairment? CNS Spectr. 2008 Mar; 13(3 Suppl 3):4-7. Feldman HH, Kandiah N. PMID: 18567135.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    144. Cognitive impairment no dementia - neuropsychological and neuroimaging characterization of an amnestic subgroup. Dement Geriatr Cogn Disord. 2008; 25(3):238-47. Jacova C, Peters KR, Beattie BL, Wong E, Riddehough A, Foti D, Scheltens P, Li DK, Feldman HH. PMID: 18264009.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    145. Clinical presentation of prodromal frontotemporal dementia. Am J Alzheimers Dis Other Demen. 2007 Dec-2008 Jan; 22(6):456-67. Hallam BJ, Silverberg ND, Lamarre AK, Mackenzie IR, Feldman HH. PMID: 18166605; PMCID: PMC10846131.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    146. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol. 2008 Jan; 65(1):45-53. Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung GY, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy-English I, Matthews PM, Owen MJ, Plumpton M, Pryse-Phillips W, Prinjha RK, Richardson JC, Saunders A, Slater AJ, St George-Hyslop PH, Stinnett SW, Swartz JE, Taylor RL, Wherrett J, Williams J, Yarnall DP, Gibson RA, Irizarry MC, Middleton LT, Roses AD. PMID: 17998437.
      View in: PubMed   Mentions: 251     Fields:    Translation:Humans
    147. Neuropsychiatric symptom clusters and functional disability in cognitively-impaired-not-demented individuals. Am J Geriatr Psychiatry. 2008 Feb; 16(2):136-44. Peters KR, Rockwood K, Black SE, Hogan DB, Gauthier SG, Loy-English I, Hsiung GY, Jacova C, Kertesz A, Feldman HH. PMID: 17928572.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    148. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. Lancet Neurol. 2007 Oct; 6(10):857-68. Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, Wood EM, Yu CE, Josephs K, Sorenson E, Womack KB, Weintraub S, Pickering-Brown SM, Schofield PR, Brooks WS, Van Deerlin VM, Snowden J, Clark CM, Kertesz A, Boylan K, Ghetti B, Neary D, Schellenberg GD, Beach TG, Mesulam M, Mann D, Grafman J, Mackenzie IR, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind DH, Miller B, Wszolek Z, Lippa C, Bigio EH, Dickson D, Graff-Radford N, Hutton M. PMID: 17826340.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    149. Neuropsychological testing and assessment for dementia. Alzheimers Dement. 2007 Oct; 3(4):299-317. Jacova C, Kertesz A, Blair M, Fisk JD, Feldman HH. PMID: 19595951.
      View in: PubMed   Mentions: 48     Fields:    
    150. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007 Aug; 6(8):734-46. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P. PMID: 17616482.
      View in: PubMed   Mentions: 1514     Fields:    Translation:Humans
    151. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol. 2007 Jun; 6(6):501-12. Feldman HH, Ferris S, Winblad B, Sfikas N, Mancione L, He Y, Tekin S, Burns A, Cummings J, del Ser T, Inzitari D, Orgogozo JM, Sauer H, Scheltens P, Scarpini E, Herrmann N, Farlow M, Potkin S, Charles HC, Fox NC, Lane R. PMID: 17509485.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    152. Rivastigmine: a placebo controlled trial of twice daily and three times daily regimens in patients with Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2007 Oct; 78(10):1056-63. Feldman HH, Lane R, Study 304 Group. PMID: 17353259; PMCID: PMC2117538.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    153. Clinical phenotypes of Cerebral Amyloid Angiopathy. J Neurol Sci. 2007 Jun 15; 257(1-2):23-30. Maia LF, Mackenzie IR, Feldman HH. PMID: 17341423.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    154. Primary prevention and delay of onset of AD/dementia. Can J Neurol Sci. 2007 Mar; 34 Suppl 1:S84-9. Feldman HH, Jacova C. PMID: 17469689.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    155. Is mild cognitive impairment a valid target of therapy. Can J Neurol Sci. 2007 Mar; 34 Suppl 1:S90-6. Rockwood K, Chertkow H, Feldman HH. PMID: 17469690.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    156. Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study. J Neurol Sci. 2007 Jan 31; 252(2):106-12. Rockwood K, Moorhouse PK, Song X, MacKnight C, Gauthier S, Kertesz A, Montgomery P, Black S, Hogan DB, Guzman A, Bouchard R, Feldman H, Consortium to Investigate Vascular Impairment of Cognition (CIVIC) Cohort. PMID: 17189642.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    157. Dropouts and refusals in observational studies: lessons for prevention trials. Neurology. 2006 Nov 14; 67(9 Suppl 3):S17-20. Jacova C, Hsiung GY, Feldman HH. PMID: 17101929.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    158. Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology. J Psychopharmacol. 2006 Nov; 20(6):732-55. Burns A, O'Brien J, BAP Dementia Consensus group, Auriacombe S, Ballard C, Broich K, Bullock R, Feldman H, Ford G, Knapp M, McCaddon A, Iliffe S, Jacova C, Jones R, Lennon S, McKeith I, Orgogozo JM, Purandare N, Richardson M, Ritchie C, Thomas A, Warner J, Wilcock G, Wilkinson D, British Association for Psychopharmacology. PMID: 17060346.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    159. The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene. Brain. 2006 Nov; 129(Pt 11):3081-90. Mackenzie IR, Baker M, Pickering-Brown S, Hsiung GY, Lindholm C, Dwosh E, Gass J, Cannon A, Rademakers R, Hutton M, Feldman HH. PMID: 17071926.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    160. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006 Oct 06; 314(5796):130-3. Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM. PMID: 17023659.
      View in: PubMed   Mentions: 3228     Fields:    Translation:HumansCells
    161. Activities of daily living in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):263-8. Feldman HH, Schmitt FA, Olin JT, Memantine MEM-MD-02 Study Group. PMID: 17132971.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    162. Outcomes of cognitively impaired not demented at 2 years in the Canadian Cohort Study of Cognitive Impairment and Related Dementias. Dement Geriatr Cogn Disord. 2006; 22(5-6):413-20. Hsiung GY, Donald A, Grand J, Black SE, Bouchard RW, Gauthier SG, Loy-English I, Hogan DB, Kertesz A, Rockwood K, Feldman HH. PMID: 16966831.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    163. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Hum Mol Genet. 2006 Oct 15; 15(20):2988-3001. Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, Wszolek Z, Gonzalez J, Beach TG, Bigio E, Johnson N, Weintraub S, Mesulam M, White CL, Woodruff B, Caselli R, Hsiung GY, Feldman H, Knopman D, Hutton M, Rademakers R. PMID: 16950801.
      View in: PubMed   Mentions: 301     Fields:    Translation:Humans
    164. Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease. BMC Neurol. 2006 Aug 31; 6:32. Mackenzie IR, Butland SL, Devon RS, Dwosh E, Feldman H, Lindholm C, Neal SJ, Ouellette BF, Leavitt BR. PMID: 16945149; PMCID: PMC1570137.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    165. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 2006 Aug 24; 442(7105):916-9. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M. PMID: 16862116.
      View in: PubMed   Mentions: 989     Fields:    Translation:HumansCells
    166. Alzheimer's Association Research Roundtable Meeting on Mild Cognitive Impairment: what have we learned? Alzheimers Dement. 2006 Jul; 2(3):220-33. Grundman M, Petersen RC, Bennett DA, Feldman HH, Salloway S, Visser PJ, Thal LJ, Schenk D, Khachaturian Z, Thies W, Alzheimer's Association Research Roundtable. PMID: 19595891.
      View in: PubMed   Mentions: 10     Fields:    
    167. Mild cognitive impairment. Lancet. 2006 Apr 15; 367(9518):1262-70. Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B, International Psychogeriatric Association Expert Conference on mild cognitive impairment. PMID: 16631882.
      View in: PubMed   Mentions: 1003     Fields:    Translation:Humans
    168. Progress in clinical neurosciences: Canadian guidelines for the development of antidementia therapies: a conceptual summary. Can J Neurol Sci. 2006 Feb; 33(1):6-26. Feldman HH, Gauthier S, Chertkow H, Conn DK, Freedman M, Chris M, 2nd Canadian Conference on Antidementia Guidelines. PMID: 16583717.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    169. A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain. 2006 Apr; 129(Pt 4):853-67. Mackenzie IR, Baker M, West G, Woulfe J, Qadi N, Gass J, Cannon A, Adamson J, Feldman H, Lindholm C, Melquist S, Pettman R, Sadovnick AD, Dwosh E, Whiteheart SW, Hutton M, Pickering-Brown SM. PMID: 16401619.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    170. Cholesterol in Alzheimer's disease. Lancet Neurol. 2005 Dec; 4(12):841-52. Shobab LA, Hsiung GY, Feldman HH. PMID: 16297842.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimals
    171. Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study. J Neurol Sci. 2006 Jan 15; 240(1-2):7-14. Rockwood K, Black SE, Song X, Hogan DB, Gauthier S, MacKnight C, Vandorpe R, Guzman A, Montgomery P, Kertesz A, Bouchard RW, Feldman H. PMID: 16212979.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    172. Mild cognitive impairment. Am J Geriatr Psychiatry. 2005 Aug; 13(8):645-55. Feldman HH, Jacova C. PMID: 16085780.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    173. Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum. J Neuropathol Exp Neurol. 2005 Aug; 64(8):730-9. Mackenzie IR, Feldman HH. PMID: 16106222.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    174. Efficacy and safety of donepezil in patients with more severe Alzheimer's disease: a subgroup analysis from a randomized, placebo-controlled trial. Int J Geriatr Psychiatry. 2005 Jun; 20(6):559-69. Feldman H, Gauthier S, Hecker J, Vellas B, Xu Y, Ieni JR, Schwam EM, Donepezil MSAD Study Investigators Group. PMID: 15920715.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCTClinical Trials
    175. Assessing mental status in dementia: the behavioral neurology assessment--right time? Right place? Can J Neurol Sci. 2005 May; 32(2):138-9. Feldman HH, Jacova C. PMID: 16018148.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    176. Neuropsychological subgroups of cognitively-impaired-not-demented (CIND) individuals: delineation, reliability, and predictive validity. J Clin Exp Neuropsychol. 2005 Feb; 27(2):164-88. Peters KR, Graf P, Hayden S, Feldman H. PMID: 15903149.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    177. Cognition, function, and caregiving time patterns in patients with mild-to-moderate Alzheimer disease: a 12-month analysis. Alzheimer Dis Assoc Disord. 2005 Jan-Mar; 19(1):29-36. Feldman HH, Van Baelen B, Kavanagh SM, Torfs KE. PMID: 15764869.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCTClinical Trials
    178. Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging. CMAJ. 2004 Oct 12; 171(8):863-7. Hsiung GY, Sadovnick AD, Feldman H. PMID: 15477624; PMCID: PMC522651.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    179. Neuropsychological characterization of cognitively-impaired-not-demented (CIND) individuals: clinical comparison data. Clin Neuropsychol. 2004 May; 18(2):208-28. Peters KR, Graf P, Hayden S, Feldman H. PMID: 15587669.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    180. Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke. 2004 Apr; 35(4):1010-7. Erkinjuntti T, Román G, Gauthier S, Feldman H, Rockwood K. PMID: 15001795.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    181. Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study. Acta Neuropathol. 2004 Apr; 107(4):336-40. Mackenzie IR, Feldman H. PMID: 14745570.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    182. What are the treatment options for patients with severe Alzheimer's disease? CNS Drugs. 2004; 18(9):575-83. Voisin T, Reynish E, Portet F, Feldman H, Vellas B. PMID: 15222774.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    183. Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases. Dement Geriatr Cogn Disord. 2004; 17(4):333-6. Mackenzie IR, Feldman H. PMID: 15178948.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    184. Dementia with Lewy bodies. Lancet Neurol. 2004 Jan; 3(1):19-28. McKeith I, Mintzer J, Aarsland D, Burn D, Chiu H, Cohen-Mansfield J, Dickson D, Dubois B, Duda JE, Feldman H, Gauthier S, Halliday G, Lawlor B, Lippa C, Lopez OL, Carlos Machado J, O'Brien J, Playfer J, Reid W, International Psychogeriatric Association Expert Meeting on DLB. PMID: 14693108.
      View in: PubMed   Mentions: 219     Fields:    Translation:Humans
    185. Fatal familial insomnia: the first account in a family of Chinese descent. Arch Neurol. 2004 Jan; 61(1):122-5. Spacey SD, Pastore M, McGillivray B, Fleming J, Gambetti P, Feldman H. PMID: 14732629.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    186. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol. 2003 Sep; 2(9):539-47. Scarpini E, Scheltens P, Feldman H. PMID: 12941576.
      View in: PubMed   Mentions: 154     Fields:    Translation:Humans
    187. The Consortium to Investigate Vascular Impairment of Cognition: methods and first findings. Can J Neurol Sci. 2003 Aug; 30(3):237-43. Rockwood K, Davis H, MacKnight C, Vandorpe R, Gauthier S, Guzman A, Montgomery P, Black S, Hogan DB, Kertesz A, Bouchard R, Feldman H. PMID: 12945949.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    188. Efficacy of donepezil on maintenance of activities of daily living in patients with moderate to severe Alzheimer's disease and the effect on caregiver burden. J Am Geriatr Soc. 2003 Jun; 51(6):737-44. Feldman H, Gauthier S, Hecker J, Vellas B, Emir B, Mastey V, Subbiah P, Donepezil MSAD Study Investigators Group. PMID: 12757558.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCTClinical Trials
    189. Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases. Acta Neuropathol. 2003 Jun; 105(6):543-8. Mackenzie IR, Feldman H. PMID: 12734660.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    190. Epidemiology and genetics of frontotemporal dementia/Pick's disease. Ann Neurol. 2003; 54 Suppl 5:S29-31. Bird T, Knopman D, VanSwieten J, Rosso S, Feldman H, Tanabe H, Graff-Raford N, Geschwind D, Verpillat P, Hutton M. PMID: 12833366.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    191. Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease. Int Psychogeriatr. 2002 Dec; 14(4):389-404. Gauthier S, Feldman H, Hecker J, Vellas B, Ames D, Subbiah P, Whalen E, Emir B, Donepezil MSAD Study Investigators Group. PMID: 12670060.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCTClinical Trials
    192. The relationship between extramotor ubiquitin-immunoreactive neuronal inclusions and dementia in motor neuron disease. Acta Neuropathol. 2003 Feb; 105(2):98-102. Mackenzie IR, Feldman H. PMID: 12536219.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    193. H.L. v. Matheson: where does the Court stand on abortion and parental notification? Am Univ Law Rev. 1982; 31(2):431-69. Feldman HN. PMID: 11658318.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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