Howard Feldman

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-9258-4538 Additional info
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    Collapse Biography 
    Collapse Education and Training
    McGill University, Quebec, CanadaMDCM06/1978Medicine
    Collapse Awards and Honors
    University of British Columbia1997Martin M Hoffman Award for Excellence in Research
    Thomson Reuters2002  - 2012Most Highly Cited Researchers in Neuroscience & Behavior; World's Most Influential Scientific Mind
    Web of Science Clarivate Analytics2007  - 2018Top 1% Most Cited Researcher in Neuroscience
    University of British Columbia2008Distinguished Achievement Award for Outstanding Contribution by a Senior Faculty Member
    Canadian Consortium of Clinical Cognitive Centres for Research (C5R)2013Irma M Parhad Award for Excellence
    Thomson Reuters2014  - 2015Most Highly Cited Researchers in Neuroscience & Behavior; World's Most Influential Scientific Mind
    Blue Ridge Institute for Medical Research2019#1 ranking PI in Neurosciences funding from the NIH

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    A Single Ascending Dose / Multiple Ascending Dose Phase I study of the GSM 776890 in healthy normal subjects
    NIH R01AG070353Feb 1, 2021 - Nov 30, 2023
    Role: Coordinating Center Principal Investigator
    Asian Cohort for Alzheimer's Disease (ACAD)
    NIH R56AG069130Sep 30, 2020 - May 31, 2022
    Role: Co-Investigator
    UCSD Alzheimer's Disease Research Centers P30
    NIH P30AG062429May 1, 2019 - Mar 31, 2024
    Role: Co-Investigator
    A Seamless Phase 2A-B Randomized Double Blind Placebo Controlled Trial to Evaluate the Efficacy and Safety of PQ 912 in Patients with Early Alzheimer's Disease
    NIH R01AG061146Apr 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Phase II RCT of High-dose Vitamin D Supplements in Older Adults without Dementia
    NIH R01AG051618Sep 15, 2017 - Mar 31, 2022
    Role: Coordinating Center Principal Investigator
    NIH R01AG047922Aug 15, 2014 - Jun 30, 2019
    Role: Principal Investigator (2018-2019)
    Alzheimer's Disease Cooperative Study
    NIH U19AG010483Jul 1, 1997 - Feb 28, 2021
    Role: Principal Investigator
    Description: Double-blind, placebo-controlled trials to determine whether various treatments slow the rate of cognitive decline in Alzheimer's disease.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Enriching the design of Alzheimer's disease clinical trials: Application of the polygenic hazard score and composite outcome measures. Alzheimers Dement (N Y). 2020; 6(1):e12071. Banks SJ, Qiu Y, Fan CC, Dale AM, Zou J, Askew B, Feldman HH, Alzheimer's Disease Neuroimaging Initiative. PMID: 32999917; PMCID: PMC7507583.
      View in: PubMed   Mentions: 5  
    2. Development of a novel cognitive composite outcome to assess therapeutic effects of exercise in the EXERT trial for adults with MCI: The ADAS-Cog-Exec. Alzheimers Dement (N Y). 2020; 6(1):e12059. Jacobs DM, Thomas RG, Salmon DP, Jin S, Feldman HH, Cotman CW, Baker LD, Alzheimer's Disease Cooperative Study EXERT Study Group, Alzheimer's Disease Neuroimaging Initiative. PMID: 32995469; PMCID: PMC7507362.
      View in: PubMed   Mentions: 4  
    3. Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults. Neurology. 2020 10 20; 95(16):e2295-e2304. Weigand AJ, Bondi MW, Thomas KR, Campbell NL, Galasko DR, Salmon DP, Sewell D, Brewer JB, Feldman HH, Delano-Wood L, Alzheimer's Disease Neuroimaging Initiative. PMID: 32878992; PMCID: PMC7713781.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    4. Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer's disease. Prog Neurobiol. 2021 02; 197:101902. Kent BA, Feldman HH, Nygaard HB. PMID: 32877742; PMCID: PMC7855222.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    5. World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020 07; 16(7):1078-1094. Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas RM, Scheltens P, Sevlever G, Soininen H, Sosa AL, Suemoto CK, Tainta-Cuezva M, Velilla L, Wang Y, Whitmer R, Whitmer R, Xu X, Bain LJ, Solomon A, Ngandu T, Carrillo MC. PMID: 32627328; PMCID: PMC9527644.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
    6. Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS). J Neuropathol Exp Neurol. 2020 07 01; 79(7):809-812. Chornenka K, Hirsch-Reinshagen V, Perez-Rosendahl M, Feldman H, Segal-Gidan F, Vinters HV, Mackenzie IR. PMID: 32483606.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020 03 16; 15(1):21. Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, Roberge M, Nygaard HB. PMID: 32178712; PMCID: PMC7075020.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures. Alzheimers Dement. 2020 01; 16(1):131-143. Boxer AL, Gold M, Feldman H, Boeve BF, Dickinson SL, Fillit H, Ho C, Paul R, Pearlman R, Sutherland M, Verma A, Arneric SP, Alexander BM, Dickerson BC, Dorsey ER, Grossman M, Huey ED, Irizarry MC, Marks WJ, Masellis M, McFarland F, Niehoff D, Onyike CU, Paganoni S, Panzara MA, Rockwood K, Rohrer JD, Rosen H, Schuck RN, Soares HD, Tatton N. PMID: 31668596; PMCID: PMC6949386.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    9. Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation. Stem Cell Res. 2019 12; 41:101582. Frew J, Wu X, Hsiung GY, Feldman HH, Mackenzie IR, Nygaard HB. PMID: 31707213.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. The "rights" of precision drug development for Alzheimer's disease. Alzheimers Res Ther. 2019 08 31; 11(1):76. Cummings J, Feldman HH, Scheltens P. PMID: 31470905; PMCID: PMC6717388.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    11. A randomized clinical trial to evaluate home-based assessment of people over 75 years old. Alzheimers Dement. 2019 05; 15(5):615-624. Sano M, Zhu CW, Kaye J, Mundt JC, Hayes TL, Ferris S, Thomas RG, Sun CK, Jiang Y, Donohue MC, Schneider LS, Egelko S, Aisen PS, Feldman HH, Alzheimer Disease Cooperative Study Investigators. PMID: 30872114.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neurobiol Aging. 2019 06; 78:74-86. Kent BA, Michalik M, Marchant EG, Yau KW, Feldman HH, Mistlberger RE, Nygaard HB. PMID: 30884411.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    13. Adaptive crossover designs for assessment of symptomatic treatments targeting behaviour in neurodegenerative disease: a phase 2 clinical trial of intranasal oxytocin for frontotemporal dementia (FOXY). Alzheimers Res Ther. 2018 09 27; 10(1):102. Finger E, Berry S, Cummings J, Coleman K, Hsiung R, Feldman HH, Boxer A. PMID: 30261917; PMCID: PMC6161323.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    14. 16-Year Survival of the Canadian Collaborative Cohort of Related Dementias. Can J Neurol Sci. 2018 07; 45(4):367-374. Lichtenstein ML, Fallah N, Mudge B, Hsiung GR, Foti D, Beattie BL, Feldman HH. PMID: 29730995.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers. Neuroimage Clin. 2018; 18:591-598. Popuri K, Dowds E, Beg MF, Balachandar R, Bhalla M, Jacova C, Buller A, Slack P, Sengdy P, Rademakers R, Wittenberg D, Feldman HH, Mackenzie IR, Hsiung GR. PMID: 29845007; PMCID: PMC5964622.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    16. Neurobehavioral characterization of adult-onset Alexander disease: A family study. Neurol Clin Pract. 2017 Oct; 7(5):425-429. Lichtenstein ML, Dwosh E, Roy Chowdhury A, Farrer MJ, McKenzie MB, Guella I, Evans DM, Nygaard HB, Shewchuk JR, Hayden S, Barton JJS, Feldman HH. PMID: 29620072; PMCID: PMC5874457.
      View in: PubMed   Mentions: 2  
    17. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017 Jul 04; 89(1):88-100. McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K. PMID: 28592453; PMCID: PMC5496518.
      View in: PubMed   Mentions: 1184     Fields:    Translation:Humans
    18. The Canadian dementia challenge: Ensuring optimal care and services for those at risk or with dementia throughout the country. Can J Public Health. 2017 04 20; 108(1):e95-e97. Feldman HH, Estabrooks CA. PMID: 28425906; PMCID: PMC6975213.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. The 2002 NIMH Provisional Diagnostic Criteria for Depression of Alzheimer's Disease (PDC-dAD): Gauging their Validity over a Decade Later. J Alzheimers Dis. 2017; 58(2):449-462. Sepehry AA, Lee PE, Hsiung GR, Beattie BL, Feldman HH, Jacova C. PMID: 28453472.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. Lancet. 2016 12 10; 388(10062):2873-2884. Gauthier S, Feldman HH, Schneider LS, Wilcock GK, Frisoni GB, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Wischik DJ, Schelter BO, Davis CS, Staff RT, Bracoud L, Shamsi K, Storey JM, Harrington CR, Wischik CM. PMID: 27863809; PMCID: PMC5164296.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCTClinical Trials
    21. A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology. 2016 Aug 02; 87(5):539-47. Jack CR, Bennett DA, Blennow K, Carrillo MC, Feldman HH, Frisoni GB, Hampel H, Jagust WJ, Johnson KA, Knopman DS, Petersen RC, Scheltens P, Sperling RA, Dubois B. PMID: 27371494; PMCID: PMC4970664.
      View in: PubMed   Mentions: 653     Fields:    Translation:Humans
    22. Defeating Alzheimer's disease and other dementias: a priority for European science and society. Lancet Neurol. 2016 Apr; 15(5):455-532. Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H. PMID: 26987701.
      View in: PubMed   Mentions: 545     Fields:    Translation:Humans
    23. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016 Mar; 12(3):292-323. Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, Epelbaum S, Frisoni GB, Gauthier S, Genthon R, Gouw AA, Habert MO, Holtzman DM, Kivipelto M, Lista S, Molinuevo JL, O'Bryant SE, Rabinovici GD, Rowe C, Salloway S, Schneider LS, Sperling R, Teichmann M, Carrillo MC, Cummings J, Jack CR, Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Ass. PMID: 27012484; PMCID: PMC6417794.
      View in: PubMed   Mentions: 635     Fields:    Translation:HumansAnimals
    24. Periventricular hyperintensities are associated with elevated cerebral amyloid. Neurology. 2016 Feb 09; 86(6):535-43. Marnane M, Al-Jawadi OO, Mortazavi S, Pogorzelec KJ, Wang BW, Feldman HH, Hsiung GY, Alzheimer's Disease Neuroimaging Initiative. PMID: 26747881; PMCID: PMC4753726.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    25. Effect of diesel exhaust inhalation on blood markers of inflammation and neurotoxicity: a controlled, blinded crossover study. Inhal Toxicol. 2016; 28(3):145-53. Cliff R, Curran J, Hirota JA, Brauer M, Feldman H, Carlsten C. PMID: 26915823.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    26. Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial. JAMA Neurol. 2015 Nov; 72(11):1324-33. Coric V, Salloway S, van Dyck CH, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Pilcher G, Ferris S, Colby S, Kerselaers W, Dockens R, Soares H, Kaplita S, Luo F, Pachai C, Bracoud L, Mintun M, Grill JD, Marek K, Seibyl J, Cedarbaum JM, Albright C, Feldman HH, Berman RM. PMID: 26414022.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCTClinical Trials
    27. Early neuropsychological characteristics of progranulin mutation carriers. J Int Neuropsychol Soc. 2014 Aug; 20(7):694-703. Hallam BJ, Jacova C, Hsiung GY, Wittenberg D, Sengdy P, Bouchard-Kerr P, Slack P, Rademakers R, Baker M, Chow TW, Levine B, Feldman HH, Mackenzie IR. PMID: 24993774.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    28. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014 Jun; 13(6):614-29. Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL. PMID: 24849862.
      View in: PubMed   Mentions: 1238     Fields:    Translation:Humans
    29. Alzheimer's disease research and development: a call for a new research roadmap. Ann N Y Acad Sci. 2014 Apr; 1313:1-16. Feldman HH, Haas M, Gandy S, Schoepp DD, Cross AJ, Mayeux R, Sperling RA, Fillit H, van de Hoef DL, Dougal S, Nye JS, One Mind for Research and the New York Academy of Sciences. PMID: 24754377.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    30. Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population. Neurobiol Aging. 2014 Apr; 35(4):936.e5-12. Omoumi A, Fok A, Greenwood T, Sadovnick AD, Feldman HH, Hsiung GY. PMID: 24176626.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    31. Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers. Neurology. 2013 Oct 08; 81(15):1322-31. Jacova C, Hsiung GY, Tawankanjanachot I, Dinelle K, McCormick S, Gonzalez M, Lee H, Sengdy P, Bouchard-Kerr P, Baker M, Rademakers R, Sossi V, Stoessl AJ, Feldman HH, Mackenzie IR. PMID: 24005336; PMCID: PMC3806924.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    32. Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia. Alzheimers Res Ther. 2013 Jul 08; 5(Suppl 1):S2. Chertkow H, Feldman HH, Jacova C, Massoud F. PMID: 24565215; PMCID: PMC3981054.
      View in: PubMed   Mentions: 54     Fields:    
    33. Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimers Dement. 2013 Mar; 9(2):123-131.e1. Carrillo MC, Brashear HR, Logovinsky V, Ryan JM, Feldman HH, Siemers ER, Abushakra S, Hartley DM, Petersen RC, Khachaturian AS, Sperling RA. PMID: 23411394.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansPHPublic Health
    34. H.L. v. Matheson: where does the Court stand on abortion and parental notification? Am Univ Law Rev. 1982; 31(2):431-69. Feldman HN. PMID: 11658318.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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