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Cassia Overk

Title(s)Associate Project Scientist, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Potential sedative mechanism for Humulus lupulus L.
    NIH F31AT002423Aug 1, 2004 - Jul 31, 2007
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2020 Sep 25. Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. PMID: 32975365.
      View in: PubMed   Mentions:    Fields:    
    2. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and a-synuclein transgenic models. J Neuroinflammation. 2020 Jul 17; 17(1):214. Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. PMID: 32680537.
      View in: PubMed   Mentions: 1     Fields:    
    3. Effects of single and combined immunotherapy approach targeting amyloid ß protein and a-synuclein in a dementia with Lewy bodies-like model. Alzheimers Dement. 2019 09; 15(9):1133-1148. Mandler M, Rockenstein E, Overk C, Mante M, Florio J, Adame A, Kim C, Santic R, Schneeberger A, Mattner F, Schmidhuber S, Galabova G, Spencer B, Masliah E, Rissman RA. PMID: 31378574.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    4. Could changing the course of Alzheimer's disease pathology with immunotherapy prevent dementia? Brain. 2019 07 01; 142(7):1853-1855. Overk C, Masliah E. PMID: 31505546.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    5. Pathogenesis of age-related HIV neurodegeneration. J Neurovirol. 2019 10; 25(5):622-633. Mackiewicz MM, Overk C, Achim CL, Masliah E. PMID: 30790184.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    6. Remembering Robert D. Terry at a Time of Change in the World of Alzheimer's Disease. J Alzheimers Dis. 2019; 70(3):621-628. Terry N, Masliah A, Overk C, Masliah E. PMID: 31282421.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies. Sci Rep. 2018 12 27; 8(1):18083. Hassen GW, Kesner L, Stracher A, Shulman A, Rockenstein E, Mante M, Adame A, Overk C, Rissman RA, Masliah E. PMID: 30591714.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. J Alzheimers Dis. 2018; 61(3):1201-1219. Arner A, Rockenstein E, Mante M, Florio J, Masliah D, Salehi B, Adame A, Overk C, Masliah E, Rissman RA. PMID: 29332037.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. Dale Schenk One Year Anniversary: Fighting to Preserve the Memories. J Alzheimers Dis. 2018; 62(1):1-13. PMID: 29439357.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018 01 24; 38(4):1000-1014. Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, Adame A, Trinh I, Kim C, Overk C, Masliah E, Rissman RA. PMID: 29246926.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Multiple system atrophy: experimental models and reality. Acta Neuropathol. 2018 01; 135(1):33-47. PMID: 29058121.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    12. Differential effects of immunotherapy with antibodies targeting a-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiol Dis. 2017 Aug; 104:85-96. El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA. PMID: 28476636.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    13. Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease. Alzheimers Dement. 2017 02; 13(2):183-185. PMID: 28130011.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. PMID: 28105557.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Anti-a-synuclein immunotherapy reduces a-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 01 13; 5(1):7. PMID: 28086964.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. PMID: 27679481.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    17. Reducing Endogenous a-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 07 27; 36(30):7971-84. PMID: 27466341.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    18. Longitudinal live imaging of retinal a-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies. Sci Rep. 2016 07 08; 6:29523. PMID: 27389831.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120. PMID: 27220536.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability. Alzheimers Dement. 2016 06; 12(6):633-44. PMID: 26776762.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    21. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015; 10(3):e0121570. PMID: 25803611.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Molecular determinants of a-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. PMID: 25561023.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    23. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. PMID: 25117211.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Toward a unified therapeutics approach targeting putative amyloid-ß oligomer receptors. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13680-1. PMID: 25205809.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Hippocampal neuronal cells that accumulate a-synuclein fragments are more vulnerable to Aß oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014 May 19; 9:18. PMID: 24885390.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    26. Accumulation of oligomer-prone a-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513. PMID: 24662516.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    27. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. PMID: 24509835.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    28. Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol. 2014 Apr 15; 88(4):508-16. PMID: 24462903.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    29. Structural diversity of Alzheimer's disease amyloid-ß dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. PMID: 24240640.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    30. Sex steroid levels and AD-like pathology in 3xTgAD mice. J Neuroendocrinol. 2013 Feb; 25(2):131-144. Overk CR, Perez SE, Ma C, Taves MD, Soma KK, Mufson EJ. PMID: 22889357.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    31. The many faces of a-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci. 2013 01; 14(1):38-48. PMID: 23254192.
      View in: PubMed   Mentions: 392     Fields:    Translation:HumansAnimalsCells
    32. Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice. Neurobiol Dis. 2012 Jan; 45(1):479-87. Overk CR, Lu PY, Wang YT, Choi J, Shaw JW, Thatcher GR, Mufson EJ. PMID: 21945538.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    33. Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AßPPswe/PS1?E9 mice. J Alzheimers Dis. 2011; 25(3):491-504. Kelley CM, Perez SE, Overk CR, Wynick D, Mufson EJ. PMID: 21471639.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    34. A novel approach for long-term oral drug administration in animal research. J Neurosci Methods. 2011 Feb 15; 195(2):194-9. Overk CR, Borgia JA, Mufson EJ. PMID: 21163304.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    35. Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease. J Chem Neuroanat. 2010 Sep; 40(1):63-70. Overk CR, Felder CC, Tu Y, Schober DA, Bales KR, Wuu J, Mufson EJ. PMID: 20347961.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    36. Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Sep; 35(3):415-25. Overk CR, Kelley CM, Mufson EJ. PMID: 19524671.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    37. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metab Dispos. 2009 Jan; 37(1):161-9. Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. PMID: 18936111.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    38. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chem Biol Interact. 2008 Oct 22; 176(1):30-9. Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. PMID: 18619951.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    39. High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Comb Chem High Throughput Screen. 2008 May; 11(4):283-93. Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. PMID: 18473738.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    40. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Adv Exp Med Biol. 2008; 617:601-7. Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. PMID: 18497087.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    41. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. ChemMedChem. 2007 Oct; 2(10):1520-6. Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. PMID: 17654759.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    42. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. . 2007 Sep; 6(9):2418-28. Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. PMID: 17876041.
      View in: PubMed   Mentions:
    43. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 2007 Oct; 148(10):4793-802. Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. PMID: 17584965.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    44. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J Altern Complement Med. 2006 Mar; 12(2):133-9. Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. PMID: 16566672.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    45. Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. J Agric Food Chem. 2006 Feb 22; 54(4):1277-82. Booth NL, Overk CR, Yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR. PMID: 16478248.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    46. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005 Aug 10; 53(16):6246-53. Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. PMID: 16076101.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    47. Estrogens and congeners from spent hops (Humulus lupulus). J Nat Prod. 2004 Dec; 67(12):2024-32. Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HH, Farnsworth NR, Pauli GF. PMID: 15620245.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    48. Purification, structure determination, and antimicrobial activity of neutramycins B-G. J Nat Prod. 2003 Sep; 66(9):1149-53. Graziani EI, Overk CR, Carter GT. PMID: 14510587.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    49. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chem Res Toxicol. 2003 Jun; 16(6):741-9. Liu X, Zhang F, Liu H, Burdette JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. PMID: 12807357.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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