Cassia Overk

Title(s)Associate Project Scientist, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Potential sedative mechanism for Humulus lupulus L.
    NIH F31AT002423Aug 1, 2004 - Jul 31, 2007
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Novel Brain-Penetrating Single Chain Antibodies Directed Against 3RTau for the Treatment of Alzheimer's Disease and Related Dementias. Methods Mol Biol. 2022; 2383:447-457. Spencer B, Rissman RA, Overk C, Masliah E. PMID: 34766306.
      View in: PubMed   Mentions:
    2. Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model. Alzheimers Dement. 2021 Nov 10. Sawa M, Overk C, Becker A, Derse D, Albay R, Weldy K, Salehi A, Beach TG, Doran E, Head E, Yu YE, Mobley WC. PMID: 34757693.
      View in: PubMed   Mentions:
    3. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2021 02; 17(2):271-292. Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. PMID: 32975365; PMCID: PMC7984396.
      View in: PubMed   Mentions: 6     Fields:    
    4. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models. J Neuroinflammation. 2020 Jul 17; 17(1):214. Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. PMID: 32680537; PMCID: PMC7368752.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model. Alzheimers Dement. 2019 09; 15(9):1133-1148. Mandler M, Rockenstein E, Overk C, Mante M, Florio J, Adame A, Kim C, Santic R, Schneeberger A, Mattner F, Schmidhuber S, Galabova G, Spencer B, Masliah E, Rissman RA. PMID: 31378574; PMCID: PMC7503212.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Could changing the course of Alzheimer's disease pathology with immunotherapy prevent dementia? Brain. 2019 07 01; 142(7):1853-1855. Overk C, Masliah E. PMID: 31505546; PMCID: PMC6933504.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    7. Pathogenesis of age-related HIV neurodegeneration. J Neurovirol. 2019 10; 25(5):622-633. Mackiewicz MM, Overk C, Achim CL, Masliah E. PMID: 30790184; PMCID: PMC6703984.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    8. Remembering Robert D. Terry at a Time of Change in the World of Alzheimer's Disease. J Alzheimers Dis. 2019; 70(3):621-628. Terry N, Masliah A, Overk C, Masliah E. PMID: 31282421; PMCID: PMC6750985.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies. Sci Rep. 2018 12 27; 8(1):18083. Hassen GW, Kesner L, Stracher A, Shulman A, Rockenstein E, Mante M, Adame A, Overk C, Rissman RA, Masliah E. PMID: 30591714; PMCID: PMC6308237.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    10. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. J Alzheimers Dis. 2018; 61(3):1201-1219. Arner A, Rockenstein E, Mante M, Florio J, Masliah D, Salehi B, Adame A, Overk C, Masliah E, Rissman RA. PMID: 29332037; PMCID: PMC6508863.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. Dale Schenk One Year Anniversary: Fighting to Preserve the Memories. J Alzheimers Dis. 2018; 62(1):1-13. Overk C, Masliah E. PMID: 29439357.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018 01 24; 38(4):1000-1014. Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, Adame A, Trinh I, Kim C, Overk C, Masliah E, Rissman RA. PMID: 29246926; PMCID: PMC5783958.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    13. Multiple system atrophy: experimental models and reality. Acta Neuropathol. 2018 01; 135(1):33-47. Overk C, Rockenstein E, Valera E, Stefanova N, Wenning G, Masliah E. PMID: 29058121; PMCID: PMC6156777.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    14. Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiol Dis. 2017 Aug; 104:85-96. El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA. PMID: 28476636; PMCID: PMC5954414.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    15. Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease. Alzheimers Dement. 2017 02; 13(2):183-185. Overk C, Masliah E. PMID: 28130011; PMCID: PMC5935121.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. PMID: 28105557; PMCID: PMC5729903.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 01 13; 5(1):7. Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E. PMID: 28086964; PMCID: PMC5237270.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    18. A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481; PMCID: PMC5840882.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    19. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 07 27; 36(30):7971-84. Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. PMID: 27466341; PMCID: PMC4961781.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    20. Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies. Sci Rep. 2016 07 08; 6:29523. Price DL, Rockenstein E, Mante M, Adame A, Overk C, Spencer B, Duong-Polk KX, Bonhaus D, Lindsey J, Masliah E. PMID: 27389831; PMCID: PMC4937425.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120. Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. PMID: 27220536; PMCID: PMC4879748.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability. Alzheimers Dement. 2016 06; 12(6):633-44. de Wilde MC, Overk CR, Sijben JW, Masliah E. PMID: 26776762; PMCID: PMC5058345.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    23. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015; 10(3):e0121570. Rockenstein E, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Bisquert A, Trejo-Morales M, Spencer B, Masliah E. PMID: 25803611; PMCID: PMC4372415.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    24. Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023; PMCID: PMC4944825.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    25. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211; PMCID: PMC4290715.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Toward a unified therapeutics approach targeting putative amyloid-β oligomer receptors. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13680-1. Overk CR, Masliah E. PMID: 25205809; PMCID: PMC4183328.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014 May 19; 9:18. Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. PMID: 24885390; PMCID: PMC4041038.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513. Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E. PMID: 24662516; PMCID: PMC3999721.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    29. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. PMID: 24509835; PMCID: PMC4324760.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol. 2014 Apr 15; 88(4):508-16. Overk CR, Masliah E. PMID: 24462903; PMCID: PMC3973539.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    31. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640; PMCID: PMC4449729.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Sex steroid levels and AD-like pathology in 3xTgAD mice. J Neuroendocrinol. 2013 Feb; 25(2):131-144. Overk CR, Perez SE, Ma C, Taves MD, Soma KK, Mufson EJ. PMID: 22889357; PMCID: PMC4065422.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    33. The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci. 2013 01; 14(1):38-48. Lashuel HA, Overk CR, Oueslati A, Masliah E. PMID: 23254192; PMCID: PMC4295774.
      View in: PubMed   Mentions: 485     Fields:    Translation:HumansAnimalsCells
    34. Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice. Neurobiol Dis. 2012 Jan; 45(1):479-87. Overk CR, Lu PY, Wang YT, Choi J, Shaw JW, Thatcher GR, Mufson EJ. PMID: 21945538; PMCID: PMC3225601.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    35. Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice. J Alzheimers Dis. 2011; 25(3):491-504. Kelley CM, Perez SE, Overk CR, Wynick D, Mufson EJ. PMID: 21471639; PMCID: PMC3307130.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    36. A novel approach for long-term oral drug administration in animal research. J Neurosci Methods. 2011 Feb 15; 195(2):194-9. Overk CR, Borgia JA, Mufson EJ. PMID: 21163304; PMCID: PMC3026878.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    37. Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease. J Chem Neuroanat. 2010 Sep; 40(1):63-70. Overk CR, Felder CC, Tu Y, Schober DA, Bales KR, Wuu J, Mufson EJ. PMID: 20347961; PMCID: PMC2864794.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    38. Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Sep; 35(3):415-25. Overk CR, Kelley CM, Mufson EJ. PMID: 19524671; PMCID: PMC3085918.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    39. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metab Dispos. 2009 Jan; 37(1):161-9. Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. PMID: 18936111; PMCID: PMC2683656.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    40. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chem Biol Interact. 2008 Oct 22; 176(1):30-9. Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. PMID: 18619951; PMCID: PMC2574795.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    41. High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Comb Chem High Throughput Screen. 2008 May; 11(4):283-93. Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. PMID: 18473738; PMCID: PMC3219440.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    42. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Adv Exp Med Biol. 2008; 617:601-7. Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. PMID: 18497087.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    43. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. ChemMedChem. 2007 Oct; 2(10):1520-6. Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. PMID: 17654759.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    44. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Mol Cancer Ther. 2007 Sep; 6(9):2418-28. Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. PMID: 17876041.
      View in: PubMed   Mentions: 17  Translation:HumansAnimalsCells
    45. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 2007 Oct; 148(10):4793-802. Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. PMID: 17584965.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    46. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J Altern Complement Med. 2006 Mar; 12(2):133-9. Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. PMID: 16566672; PMCID: PMC1780253.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    47. Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. J Agric Food Chem. 2006 Feb 22; 54(4):1277-82. Booth NL, Overk CR, Yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR. PMID: 16478248; PMCID: PMC1903374.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    48. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005 Aug 10; 53(16):6246-53. Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. PMID: 16076101; PMCID: PMC1815392.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    49. Estrogens and congeners from spent hops (Humulus lupulus). J Nat Prod. 2004 Dec; 67(12):2024-32. Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HH, Farnsworth NR, Pauli GF. PMID: 15620245; PMCID: PMC7418824.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    50. Purification, structure determination, and antimicrobial activity of neutramycins B-G. J Nat Prod. 2003 Sep; 66(9):1149-53. Graziani EI, Overk CR, Carter GT. PMID: 14510587.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    51. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chem Res Toxicol. 2003 Jun; 16(6):741-9. Liu X, Zhang F, Liu H, Burdette JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. PMID: 12807357.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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