Cassia Overk

Title(s)	Associate Project Scientist, Neurosciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Potential sedative mechanism for Humulus lupulus L.
NIH F31AT002423Aug 1, 2004 - Jul 31, 2007
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimers Dement. 2021 02; 17(2):271-292. Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. PMID: 32975365.

View in: PubMed Mentions: 6 Fields:
Neu Neurology Psy Psychiatry
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models. J Neuroinflammation. 2020 Jul 17; 17(1):214. Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. PMID: 32680537.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Humans Animals Cells
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model. Alzheimers Dement. 2019 09; 15(9):1133-1148. Mandler M, Rockenstein E, Overk C, Mante M, Florio J, Adame A, Kim C, Santic R, Schneeberger A, Mattner F, Schmidhuber S, Galabova G, Spencer B, Masliah E, Rissman RA. PMID: 31378574.

View in: PubMed Mentions: 1 Fields:
Neu Neurology Psy Psychiatry
Translation:Humans Animals
Could changing the course of Alzheimer's disease pathology with immunotherapy prevent dementia? Brain. 2019 07 01; 142(7):1853-1855. Overk C, Masliah E. PMID: 31505546.

View in: PubMed Mentions: 1 Fields:
Bra Brain Neu Neurology
Translation:Humans PHPublic Health
Pathogenesis of age-related HIV neurodegeneration. J Neurovirol. 2019 10; 25(5):622-633. Mackiewicz MM, Overk C, Achim CL, Masliah E. PMID: 30790184.

View in: PubMed Mentions: 14 Fields:
Neu Neurology Vir Virology
Translation:Humans Cells
Remembering Robert D. Terry at a Time of Change in the World of Alzheimer's Disease. J Alzheimers Dis. 2019; 70(3):621-628. Terry N, Masliah A, Overk C, Masliah E. PMID: 31282421.

View in: PubMed Mentions: Fields:
Ger Geriatrics Neu Neurology
Translation:Humans
Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies. Sci Rep. 2018 12 27; 8(1):18083. Hassen GW, Kesner L, Stracher A, Shulman A, Rockenstein E, Mante M, Adame A, Overk C, Rissman RA, Masliah E. PMID: 30591714.

View in: PubMed Mentions: 9 Fields:
Sci Science
Translation:Animals Cells
Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. J Alzheimers Dis. 2018; 61(3):1201-1219. Arner A, Rockenstein E, Mante M, Florio J, Masliah D, Salehi B, Adame A, Overk C, Masliah E, Rissman RA. PMID: 29332037.

View in: PubMed Mentions: 2 Fields:
Ger Geriatrics Neu Neurology
Translation:Humans Animals
Dale Schenk One Year Anniversary: Fighting to Preserve the Memories. J Alzheimers Dis. 2018; 62(1):1-13. Overk C, Masliah E. PMID: 29439357.

View in: PubMed Mentions: 1 Fields:
Ger Geriatrics Neu Neurology
Translation:Humans
Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018 01 24; 38(4):1000-1014. Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, Adame A, Trinh I, Kim C, Overk C, Masliah E, Rissman RA. PMID: 29246926.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Humans Animals Cells PHPublic Health
Multiple system atrophy: experimental models and reality. Acta Neuropathol. 2018 01; 135(1):33-47. Overk C, Rockenstein E, Valera E, Stefanova N, Wenning G, Masliah E. PMID: 29058121.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Humans Animals
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiol Dis. 2017 Aug; 104:85-96. El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA. PMID: 28476636.

View in: PubMed Mentions: 30 Fields:
Neu Neurology
Translation:Animals Cells
Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease. Alzheimers Dement. 2017 02; 13(2):183-185. Overk C, Masliah E. PMID: 28130011.

View in: PubMed Mentions: 4 Fields:
Neu Neurology Psy Psychiatry
Translation:Humans Animals Cells
The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. PMID: 28105557.

View in: PubMed Mentions: 7 Fields:
Neu Neurology Vir Virology
Translation:Humans Animals Cells
Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 01 13; 5(1):7. Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E. PMID: 28086964.

View in: PubMed Mentions: 29 Fields:
Neu Neurology
Translation:Humans Animals Cells
A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481.

View in: PubMed Mentions: 41 Fields:
Bra Brain Neu Neurology
Translation:Humans Animals
Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 07 27; 36(30):7971-84. Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. PMID: 27466341.

View in: PubMed Mentions: 18 Fields:
Neu Neurology
Translation:Animals Cells
Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies. Sci Rep. 2016 07 08; 6:29523. Price DL, Rockenstein E, Mante M, Adame A, Overk C, Spencer B, Duong-Polk KX, Bonhaus D, Lindsey J, Masliah E. PMID: 27389831.

View in: PubMed Mentions: 10 Fields:
Sci Science
Translation:Humans Animals Cells
Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120. Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. PMID: 27220536.

View in: PubMed Mentions: 13 Fields:
Neu Neurology
Translation:Animals Cells
Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability. Alzheimers Dement. 2016 06; 12(6):633-44. de Wilde MC, Overk CR, Sijben JW, Masliah E. PMID: 26776762.

View in: PubMed Mentions: 36 Fields:
Neu Neurology Psy Psychiatry
Translation:Humans Cells
A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015; 10(3):e0121570. Rockenstein E, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Bisquert A, Trejo-Morales M, Spencer B, Masliah E. PMID: 25803611.

View in: PubMed Mentions: 12 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023.

View in: PubMed Mentions: 14 Fields:
Neu Neurology
Translation:Humans Animals Cells
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211.

View in: PubMed Mentions: 10 Fields:
Pha Pharmacology
Translation:Animals Cells
Toward a unified therapeutics approach targeting putative amyloid-β oligomer receptors. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13680-1. Overk CR, Masliah E. PMID: 25205809.

View in: PubMed Mentions: 6 Fields:
Sci Science
Translation:Animals Cells
Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014 May 19; 9:18. Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. PMID: 24885390.

View in: PubMed Mentions: 25 Fields:
Mol Molecular Biology Neu Neurology
Translation:Humans Animals Cells
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513. Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E. PMID: 24662516.

View in: PubMed Mentions: 81 Fields:
Bra Brain Neu Neurology
Translation:Humans Animals Cells
Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. PMID: 24509835.

View in: PubMed Mentions: 15 Fields:
Neu Neurology
Translation:Humans Animals Cells
Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease. Biochem Pharmacol. 2014 Apr 15; 88(4):508-16. Overk CR, Masliah E. PMID: 24462903.

View in: PubMed Mentions: 77 Fields:
Bio Biochemistry Pha Pharmacology
Translation:Humans Cells
Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640.

View in: PubMed Mentions: 12 Fields:
Ger Geriatrics Neu Neurology
Translation:Humans Animals Cells
Sex steroid levels and AD-like pathology in 3xTgAD mice. J Neuroendocrinol. 2013 Feb; 25(2):131-144. Overk CR, Perez SE, Ma C, Taves MD, Soma KK, Mufson EJ. PMID: 22889357.

View in: PubMed Mentions: 9 Fields:
End Endocrinology Neu Neurology
Translation:Humans Animals
The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci. 2013 01; 14(1):38-48. Lashuel HA, Overk CR, Oueslati A, Masliah E. PMID: 23254192.

View in: PubMed Mentions: 474 Fields:
Neu Neurology
Translation:Humans Animals Cells
Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice. Neurobiol Dis. 2012 Jan; 45(1):479-87. Overk CR, Lu PY, Wang YT, Choi J, Shaw JW, Thatcher GR, Mufson EJ. PMID: 21945538.

View in: PubMed Mentions: 18 Fields:
Neu Neurology
Translation:Animals Cells
Effect of neocortical and hippocampal amyloid deposition upon galaninergic and cholinergic neurites in AβPPswe/PS1ΔE9 mice. J Alzheimers Dis. 2011; 25(3):491-504. Kelley CM, Perez SE, Overk CR, Wynick D, Mufson EJ. PMID: 21471639.

View in: PubMed Mentions: 12 Fields:
Ger Geriatrics Neu Neurology
Translation:Humans Animals Cells
A novel approach for long-term oral drug administration in animal research. J Neurosci Methods. 2011 Feb 15; 195(2):194-9. Overk CR, Borgia JA, Mufson EJ. PMID: 21163304.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Translation:Humans Animals
Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease. J Chem Neuroanat. 2010 Sep; 40(1):63-70. Overk CR, Felder CC, Tu Y, Schober DA, Bales KR, Wuu J, Mufson EJ. PMID: 20347961.

View in: PubMed Mentions: 12 Fields:
Ana Anatomy Che Chemistry Neu Neurology
Translation:Humans Cells
Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Sep; 35(3):415-25. Overk CR, Kelley CM, Mufson EJ. PMID: 19524671.

View in: PubMed Mentions: 24 Fields:
Neu Neurology
Translation:Humans Animals Cells
Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metab Dispos. 2009 Jan; 37(1):161-9. Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. PMID: 18936111.

View in: PubMed Mentions: 10 Fields:
Pha Pharmacology
Translation:Humans Animals Cells
In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chem Biol Interact. 2008 Oct 22; 176(1):30-9. Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. PMID: 18619951.

View in: PubMed Mentions: 27 Fields:
Bio Biochemistry Pha Pharmacology
Translation:Animals Cells
High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Comb Chem High Throughput Screen. 2008 May; 11(4):283-93. Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. PMID: 18473738.

View in: PubMed Mentions: 7 Fields:
Che Chemistry Mol Molecular Biology
Translation:Humans Cells
Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Adv Exp Med Biol. 2008; 617:601-7. Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. PMID: 18497087.

View in: PubMed Mentions: 1 Fields:
Bio Biology Med Medicine (General)
Translation:Humans Animals Cells
Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. ChemMedChem. 2007 Oct; 2(10):1520-6. Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. PMID: 17654759.

View in: PubMed Mentions: 17 Fields:
Che Chemistry Pha Pharmacology
Translation:Animals
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. . 2007 Sep; 6(9):2418-28. Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. PMID: 17876041.

View in: PubMed Mentions:
Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 2007 Oct; 148(10):4793-802. Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. PMID: 17584965.

View in: PubMed Mentions: 8 Fields:
End Endocrinology
Translation:Humans Cells
The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. J Altern Complement Med. 2006 Mar; 12(2):133-9. Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. PMID: 16566672.

View in: PubMed Mentions: 27 Fields:
Com Complementary Therapies
Translation:Humans Animals Cells
Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. J Agric Food Chem. 2006 Feb 22; 54(4):1277-82. Booth NL, Overk CR, Yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR. PMID: 16478248.

View in: PubMed Mentions: 12 Fields:
Che Chemistry Nut Nutritional Sciences
Translation:Humans Animals Cells
Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005 Aug 10; 53(16):6246-53. Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. PMID: 16076101.

View in: PubMed Mentions: 39 Fields:
Che Chemistry Nut Nutritional Sciences
Translation:Humans Animals Cells
Estrogens and congeners from spent hops (Humulus lupulus). J Nat Prod. 2004 Dec; 67(12):2024-32. Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HH, Farnsworth NR, Pauli GF. PMID: 15620245.

View in: PubMed Mentions: 30 Fields:
Pha Pharmacology
Translation:Humans Animals Cells
Purification, structure determination, and antimicrobial activity of neutramycins B-G. J Nat Prod. 2003 Sep; 66(9):1149-53. Graziani EI, Overk CR, Carter GT. PMID: 14510587.

View in: PubMed Mentions: 2 Fields:
Pha Pharmacology
Translation:Cells
Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chem Res Toxicol. 2003 Jun; 16(6):741-9. Liu X, Zhang F, Liu H, Burdette JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. PMID: 12807357.

View in: PubMed Mentions: 1 Fields:
Tox Toxicology
Translation:Animals Cells