JoAnn Trejo

Title(s)Professor and Assistant Vice Chancellor of Faculty Affairs, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0636
La Jolla CA 92093
ORCID ORCID Icon0000-0003-4405-6228 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, Rady School of ManagementM.B.A.2015Leadership, Finance, Management
    University of California, San Diego, School of MedicinePh.D.1992Physiology, Pharmacology
    University of California, DavisB.S.1986Toxicology, Biochemistry
    Collapse Awards and Honors
    2020American Society for Cell Biology Prize for Excellence in Inclusivity
    2020Elected, American Society for Cell Biology Fellow
    2020Elected, 100 Inspiring Latinx/Hispanic Scientists | Cell Press
    2019Society for the Advancement of Chicanos and Native Americans in Science Outstanding Mentor Award
    2017American Society for Cell Biology EE Just Award for Outstanding Scientific Achievement
    2016UC San Diego Inclusive Excellence Award
    2015American Society for Biochemistry and Molecular Biology Ruth Kirchstein Outstanding Scientist Award
    2014UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring
    2012Women Who Mean Business Award, San Diego Business Journal
    2006American Heart Association Established Investigator Award
    1995American Heart Association Scientist Career Development Grant Award
    1993University of California President’s Postdoctoral Fellowship Award

    Collapse Overview 
    Collapse Overview
    JoAnn Trejo (BS, UC Davis; PhD and MBA, UC San Diego) completed her postdoctoral fellowship at UC San Francisco and accepted her first faculty position at the University of North Carolina, Chapel Hill, in 2000. She was recruited to UC San Diego in 2008, and promoted to full professor with tenure in 2012. In 2014, she was appointed Vice Chair of the Department Pharmacology. JoAnn is best known for her discoveries on cell signaling by protease-activated G protein-coupled receptors. She has made numerous discoveries related to the regulation of cell signaling in vascular endothelial cells and breast cancer published in prominent journals. Her work has been continuously funded by the NIH, UC Tobacco-related Disease Research Program, Komen Foundation, and the American Heart Association (AHA) including the prestigious AHA Established Investigator Award. She is also a leader in the scientific community and elected by her peers to serve on Council of the American Society for Cell Biology and American Society for Biochemistry and Molecular Biology, as Chair of two Gordon Research Conferences and multiple NIH and HHMI Study Sections. She currently serves on the Board of Scientific Counselors for Basic Sciences for NCI.

    JoAnn is also an advocate for equity, diversity and inclusive excellence. She is a member of several educational training programs and active in various national committees aimed at increasing equity and inclusion of women and under-represented ethnic/racial groups in science. JoAnn is the director for the NIH/NIGMS Institutional Research and Academic Career Development Award (IRACDA) Postdoctoral Training Program at UC San Diego that aims to enhance the diversity of academia - 65% of the trainees have obtained tenure-track faculty positions at academic institutions. She received the UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring in 2014. In 2015, she became Associate Dean for Health Sciences Faculty Affairs, and in 2019 Assistant Vice Chancellor for Health Sciences Faculty Affairs where she has made great strides in developing and implementing strategies, programs and initiatives to enhance faculty success as well as to enhance the recruitment, retention and development of an engaged diverse faculty, and to support a climate of inclusive excellence. Under JoAnn's direction, the UCSD Health Sciences Office of Faculty Affairs received a HRSA-funded Hispanic Center of Excellence Award in 2017, NIH/NHLBI PRIDE UCSD Future Faculty of Cardiovascular Sciences in 2019, NIH/NINDS UCSD Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) in 2020, and NIH/NIAD UCSD Raising Advancement and Parity for Infectious Disease Researchers (RAPID) in 2020.

    Collapse Research 
    Collapse Research Activities and Funding
    UC San Diego RAPID Faculty Development Program in Infectious Diseases
    NIH R25AI147376Aug 10, 2020 - Jul 31, 2025
    Role: Principal Investigator
    San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Program
    NIH R25NS117367Aug 1, 2020 - Jul 31, 2025
    Role: Principal Investigator
    UCSD PRIDE Faculty Development Program in Cardiovascular Sciences
    NIH R25HL145817Feb 8, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Cell Signaling by Protease-activated G Protein-coupled Receptors
    NIH R35GM127121Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    GPCR Cytoprotective Signaling Mechanisms
    NIH R01GM116597Sep 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    2013 Molecular Pharmacology Gordon Research Conference and Gordon Research Semina
    NIH R13DA035525Apr 24, 2013 - Mar 31, 2014
    Role: Principal Investigator
    Mechanisms Regulating GPCR Trafficking
    NIH R01GM090689Jan 1, 2010 - Dec 31, 2018
    Role: Principal Investigator
    Symposium on Extracellular and Membrane Proteases in Cell Signaling
    NIH R13CA135997Sep 4, 2008 - Aug 31, 2009
    Role: Principal Investigator
    San Diego IRACDA: Professors for the Future
    NIH/NCATS K12GM068524Aug 1, 2003 - Jun 30, 2021
    Role: Principal Investigator
    Regulation of Protease-activated Receptor-1 Signaling
    NIH R01HL073328Apr 1, 2003 - Dec 31, 2013
    Role: Principal Investigator
    Molecular Mechanisms of PAR1 Downregulation
    NIH K01HL067697Apr 15, 2001 - Mar 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. a-arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. J Cell Sci. 2021 Mar 15. Arakaki AKS, Pan WA, Wedegaertner H, Roca-Mercado I, Chinn L, Gujral TS, Trejo J. PMID: 33722977.
      View in: PubMed   Mentions:    Fields:    
    2. Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time. Pharmacol Rev. 2021 Jan; 73(1):120-151. Patwardhan A, Cheng N, Trejo J. PMID: 33268549.
      View in: PubMed   Mentions:    Fields:    
    3. The burden of service for faculty of color to achieve diversity and inclusion: the minority tax. Mol Biol Cell. 2020 12 01; 31(25):2752-2754. Trejo J. PMID: 33253072.
      View in: PubMed   Mentions:    Fields:    
    4. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020 11 30; 11(1):6088. Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. PMID: 33257668.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Subcellular hot spots of GPCR signaling promote vascular inflammation. Curr Opin Endocr Metab Res. 2021 Feb; 16:37-42. Birch CA, Molinar-Inglis O, Trejo J. PMID: 32838054.
      View in: PubMed   Mentions:
    6. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep. 2020 08 03; 10(1):13063. Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA. PMID: 32747664.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    7. Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. Elife. 2020 05 26; 9. Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J. PMID: 32452765.
      View in: PubMed   Mentions: 2     Fields:    
    8. Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):5039-5048. Lin Y, Wozniak JM, Grimsey NJ, Girada S, Patwardhan A, Molinar-Inglis O, Smith TH, Lapek JD, Gonzalez DJ, Trejo J. PMID: 32071217.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem. 2019 04 12; 294(15):5867-5878. Grimsey NJ, Lin Y, Narala R, Rada CC, Mejia-Pena H, Trejo J. PMID: 30760523.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep. 2018 09 18; 24(12):3312-3323.e5. Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. PMID: 30232011.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling. Int J Mol Sci. 2018 Jun 27; 19(7). Arakaki AKS, Pan WA, Trejo J. PMID: 29954076.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    12. Faculty Equity, Diversity, Culture and Climate Change in Academic Medicine: A Longitudinal Study. J Natl Med Assoc. 2019 Feb; 111(1):46-53. Wingard D, Trejo J, Gudea M, Goodman S, Reznik V. PMID: 30129483.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal. 2018 02 13; 11(517). Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. PMID: 29440509.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    14. A reflection on faculty diversity in the 21st century. Mol Biol Cell. 2017 Nov 01; 28(22):2911-2914. Trejo J. PMID: 29084907.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of ß-Arrestins. J Biol Chem. 2016 08 26; 291(35):18453-64. Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. PMID: 27402844.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif. PLoS One. 2016; 11(6):e0157587. Dores MR, Grimsey NJ, Mendez F, Trejo J. PMID: 27301021.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    17. Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin. Curr Opin Hematol. 2016 May; 23(3):274-9. Grimsey NJ, Trejo J. PMID: 26845544.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. J Biol Chem. 2016 Jan 29; 291(5):2223-36. Grimsey NJ, Coronel LJ, Cordova IC, Trejo J. PMID: 26635365.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. The a-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. Mol Biol Cell. 2015 Dec 15; 26(25):4660-73. Dores MR, Lin H, J Grimsey N, Mendez F, Trejo J. PMID: 26490116.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. PMID: 26391660.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. GPCR sorting at multivesicular endosomes. Methods Cell Biol. 2015; 130:319-32. Dores MR, Trejo J. PMID: 26360043.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):E3600-8. Soto AG, Smith TH, Chen B, Bhattacharya S, Cordova IC, Kenakin T, Vaidehi N, Trejo J. PMID: 26100877.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    23. Group B streptococcal infection and activation of human astrocytes. PLoS One. 2015; 10(6):e0128431. Stoner TD, Weston TA, Trejo J, Doran KS. PMID: 26030618.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. PMID: 26004360.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro. Mol Pharmacol. 2015 Jul; 88(1):95-105. Chen B, Soto AG, Coronel LJ, Goss A, van Ryn J, Trejo J. PMID: 25934730.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454. Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. PMID: 24489642.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    27. Endosomal signaling by protease-activated receptors. Methods Enzymol. 2014; 535:389-401. Grimsey N, Lin H, Trejo J. PMID: 24377935.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination. Curr Opin Cell Biol. 2014 Apr; 27:44-50. Dores MR, Trejo J. PMID: 24680429.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    29. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. PMID: 24297163.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev. 2013; 65(4):1198-213. Lin H, Liu AP, Smith TH, Trejo J. PMID: 24064459.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    31. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, ß-arrestin-mediated internalization. J Biol Chem. 2013 Nov 08; 288(45):32194-32210. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. PMID: 24056371.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting. J Biol Chem. 2013 May 31; 288(22):15900-12. Canto I, Trejo J. PMID: 23580642.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    33. Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits ß-arrestin-mediated endosomal signaling. J Biol Chem. 2013 Apr 19; 288(16):11203-15. Lin H, Trejo J. PMID: 23476015.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    34. PAR-1 contributes to the innate immune response during viral infection. J Clin Invest. 2013 Mar; 123(3):1310-22. Antoniak S, Owens AP, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N. PMID: 23391721.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    35. Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. Cell Signal. 2013 Mar; 25(3):707-16. Marchese A, Trejo J. PMID: 23201781.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    36. Allosteric modulation of protease-activated receptor signaling. Mini Rev Med Chem. 2012 Aug; 12(9):804-11. Canto I, Soh UJ, Trejo J. PMID: 22681248.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. Mol Biol Cell. 2012 Sep; 23(18):3612-23. Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J. PMID: 22833563.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    38. Ubiquitination of G protein-coupled receptors: functional implications and drug discovery. Mol Pharmacol. 2012 Oct; 82(4):563-70. Dores MR, Trejo J. PMID: 22700696.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J Cell Biol. 2012 Apr 30; 197(3):407-19. Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T, Trejo J. PMID: 22547407.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    40. Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012 Mar 16; 287(12):9013-27. Malik R, Soh UJ, Trejo J, Marchese A. PMID: 22275353.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    41. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through ß-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):E1372-80. Soh UJ, Trejo J. PMID: 22106258.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    42. Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals. J Biol Chem. 2011 Nov 25; 286(47):40760-70. Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J. PMID: 21965661.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    43. Regulation of protease-activated receptor signaling by post-translational modifications. IUBMB Life. 2011 Jun; 63(6):403-11. Grimsey N, Soto AG, Trejo J. PMID: 21438117.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    44. RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. . 2010 Sep; 299(3):C654-64. Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. PMID: 20573995.
      View in: PubMed   Mentions:
    45. Signal transduction by protease-activated receptors. Br J Pharmacol. 2010 May; 160(2):191-203. Soh UJ, Dores MR, Chen B, Trejo J. PMID: 20423334.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    46. N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. J Biol Chem. 2010 Jun 11; 285(24):18781-93. Soto AG, Trejo J. PMID: 20368337.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    47. Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J Biol Chem. 2009 Dec 04; 284(49):34444-57. Ricks TK, Trejo J. PMID: 19815543.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    48. Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem. 2009 Jul 31; 284(31):20638-48. Seminario-Vidal L, Kreda S, Jones L, O'Neal W, Trejo J, Boucher RC, Lazarowski ER. PMID: 19439413.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    49. Proteases display biased agonism at protease-activated receptors: location matters! Mol Interv. 2009 Apr; 9(2):87-96. Russo A, Soh UJ, Trejo J. PMID: 19401541.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    50. Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6393-7. Russo A, Soh UJ, Paing MM, Arora P, Trejo J. PMID: 19332793.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    51. Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. Oncogene. 2008 Jul 24; 27(32):4434-45. Arora P, Cuevas BD, Russo A, Johnson GL, Trejo J. PMID: 18372913.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    52. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res. 2008 May; 36(8):2764-76. Alam MR, Dixit V, Kang H, Li ZB, Chen X, Trejo J, Fisher M, Juliano RL. PMID: 18367474.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    53. G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol. 2008; 48:601-29. Marchese A, Paing MM, Temple BR, Trejo J. PMID: 17995450.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    54. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21; 282(51):36971-9. Bhandari D, Trejo J, Benovic JL, Marchese A. PMID: 17947233.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    55. Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol. 2007 Jun 04; 177(5):905-16. Wolfe BL, Marchese A, Trejo J. PMID: 17535965.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    56. Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol. 2007 May; 14(3):230-5. Traynelis SF, Trejo J. PMID: 17414212.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    57. Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic. 2007 May; 8(5):462-70. Wolfe BL, Trejo J. PMID: 17376169.
      View in: PubMed   Mentions: 97     Fields:    
    58. Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. J Cell Sci. 2007 Mar 15; 120(Pt 6):921-8. Arora P, Ricks TK, Trejo J. PMID: 17344429.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    59. Cryptic messages: is noncoagulant tissue factor reserved for cell signaling? Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14259-60. Camerer E, Trejo J. PMID: 16985001.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    60. Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell. 2006 Sep; 17(9):4142-55. Dho SE, Trejo J, Siderovski DP, McGlade CJ. PMID: 16837553.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    61. Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol. 2006 Apr; 26(8):3231-42. Paing MM, Johnston CA, Siderovski DP, Trejo J. PMID: 16581796.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    62. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006 Mar; 17(3):1228-38. Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J. PMID: 16407403.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    63. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res. 2006 Jan 01; 66(1):307-14. Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J. PMID: 16397244.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    64. A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. J Cell Sci. 2005 Nov 15; 118(Pt 22):5291-304. Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H. PMID: 16263766.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    65. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15173-7. Griffin CT, Trejo J, Magnuson T. PMID: 16214895.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    66. Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors. Mol Pharmacol. 2005 May; 67(5):1388-90. Trejo J. PMID: 15713849.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    67. Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol. 2005 Jan; 67(1):78-87. Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J. PMID: 15475570.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    68. A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization. J Biol Chem. 2004 May 21; 279(21):21938-47. Paing MM, Temple BR, Trejo J. PMID: 15023990.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    69. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol. 2004 Mar; 24(5):1990-9. Booden MA, Eckert LB, Der CJ, Trejo J. PMID: 14966279.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    70. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004 May; 15(5):2143-55. Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J. PMID: 14978220.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    71. Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10020-31. Chen CH, Paing MM, Trejo J. PMID: 14699102.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    72. Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking. J Pharmacol Exp Ther. 2003 Nov; 307(2):437-42. Trejo J. PMID: 12966163.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    73. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. PMID: 10893235.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    74. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21. Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. PMID: 10590056.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    75. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24. Trejo J, Coughlin SR. PMID: 9890984.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    76. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702. Trejo J, Hammes SR, Coughlin SR. PMID: 9811863.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    77. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80. Shapiro MJ, Trejo J, Zeng D, Coughlin SR. PMID: 8955127.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    78. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41. Trejo J, Connolly AJ, Coughlin SR. PMID: 8702939.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    79. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 1996 May 01; 6(5):598-605. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. PMID: 8805275.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    80. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. Trejo J, Massamiri T, Deng T, Dewji NN, Bayney RM, Brown JH. PMID: 8063812.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    81. Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol. 1992 Oct; 12(10):4742-50. Trejo J, Chambard JC, Karin M, Brown JH. PMID: 1328861.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    82. c-fos and c-jun are induced by muscarinic receptor activation of protein kinase C but are differentially regulated by intracellular calcium. J Biol Chem. 1991 Apr 25; 266(12):7876-82. Trejo J, Brown JH. PMID: 1902229.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    83. Multiple pathways for signal transduction through the muscarinic cholinergic receptor. Prog Brain Res. 1990; 84:21-9. Brown JH, Trilivas I, Trejo J, Martinson E. PMID: 2267298.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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