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    JoAnn Trejo

    TitleProfessor and Associate Dean Faculty Affairs
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0636
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      University of California, San DiegoM.B.A.2015Rady School of Management
      University of California, San DiegoPh.D.1992School of Medicine
      University of California, DavisB.S.1986Toxicology/Biochemistry
      Collapse Awards and Honors
      2017American Society for Cell Biology EE Just Award
      2016UC San Diego Equal Opportunity/Affirmative Action and Diversity Award
      2015American Society for Biochemistry and Molecular Biology Ruth Kirchstein Diversity in Science Award
      2014UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring
      2012Women Who Mean Business Award, San Diego Business Journal
      2006American Heart Association Established Investigator Award
      1995American Heart Association Scientist Career Development Grant Award
      1993University of California President’s Postdoctoral Fellowship Award

      Collapse Overview 
      Collapse Overview
      JoAnn Trejo (BS, UC Davis; PhD and MBA, UC San Diego) completed her postdoctoral fellowship at UC San Francisco and accepted her first faculty position at the University of North Carolina, Chapel Hill, in 2000. She was recruited to UC San Diego in 2008, and promoted to full professor with tenure in 2012. In 2014, she was appointed Vice Chair of the Department Pharmacology. JoAnn is best known for her groundbreaking discoveries on cell signaling by protease-activated G protein-coupled receptors. JoAnn has made numerous novel discoveries related to the regulation of cell signaling in vascular endothelial cells and breast cancer published in prominent journals. Her work has been continuously funded by the NIH, UC Tobacco-related Disease Research Program, Komen Foundation, and the American Heart Association (AHA) including the prestigious AHA Established Investigator Award. She is also a leader in the scientific community and elected by her peers to serve on Council of the American Society for Cell Biology and American Society for Biochemistry and Molecular Biology, as Chair of two Gordon Research Conferences and multiple NIH and HHMI Study Sections. She has also presented several distinguished and keynote lectures.

      JoAnn is not only an innovative researcher that is pioneering new frontiers in cell signaling but her early life experiences have inspired her to become an advocate for diversity. She is a member of several graduate and undergraduate educational training programs and she has been active in various national committees aimed at increasing the representation of women and under-represented ethnic/racial groups in science and in our educational institutions. In 2008, JoAnn became director for the Institutional Research and Academic Career Development Award (IRACDA) Postdoctoral Training Program at UC San Diego. The NIH-sponsored IRACDA training program aims to increase the diversity of academia. Under JoAnn’s leadership, the program has been twice renewed by the NIH and has an impressive track record with 65% of the trainees, mostly under-represented minorities and women, obtaining faculty positions at academic institutions. She received the UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring in 2014. In 2015, she became Associate Dean for Health Sciences Faculty Affairs, where she has made great strides in institutionalizing faculty diversity, developing and implementing strategies, programs and initiatives for the recruitment, retention and development of a diverse faculty, and to support a climate of inclusive excellence.

      Collapse Research 
      Collapse Research Activities and Funding
      Cell Signaling by Protease-activated G Protein-coupled Receptors
      NIH/NIGMS R35GM127121Apr 1, 2018 - Mar 31, 2023
      Role: Principal Investigator
      GPCR Cytoprotective Signaling Mechanisms
      NIH/NIGMS R01GM116597Sep 1, 2015 - Jul 31, 2019
      Role: Principal Investigator
      2013 Molecular Pharmacology Gordon Research Conference and Gordon Research Semina
      NIH/NIDA R13DA035525Apr 24, 2013 - Mar 31, 2014
      Role: Principal Investigator
      Mechanisms Regulating GPCR Trafficking
      NIH/NIGMS R01GM090689Jan 1, 2010 - Dec 31, 2018
      Role: Principal Investigator
      Symposium on Extracellular and Membrane Proteases in Cell Signaling
      NIH/NCI R13CA135997Sep 4, 2008 - Aug 31, 2009
      Role: Principal Investigator
      San Diego IRACDA: Professors for the Future
      NIH/NIGMS K12GM068524Aug 1, 2003 - Jun 30, 2021
      Role: Principal Investigator
      Regulation of Protease-activated Receptor-1 Signaling
      NIH/NHLBI R01HL073328Apr 1, 2003 - Dec 31, 2013
      Role: Principal Investigator
      Molecular Mechanisms of PAR1 Downregulation
      NIH/NHLBI K01HL067697Apr 15, 2001 - Mar 31, 2006
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Featured Publications
      Collapse Websites
      Collapse Faculty Mentoring
      Collapse Twitter
      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Smith TH, Li JG, Dores MR, Trejo J. Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of ß-arrestin. J Biol Chem. 2017 Aug 18; 292(33):13867-13878. PMID: 28652403.
        View in: PubMed
      2. Hamilton JR, Trejo J. Challenges and Opportunities in Protease-Activated Receptor Drug Development. Annu Rev Pharmacol Toxicol. 2017 Jan 06; 57:349-373. PMID: 27618736.
        View in: PubMed
      3. Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of ß-Arrestins. J Biol Chem. 2016 Aug 26; 291(35):18453-64. PMID: 27402844; PMCID: PMC5000090 [Available on 08/26/17].
      4. Dores MR, Grimsey NJ, Mendez F, Trejo J. ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif. PLoS One. 2016; 11(6):e0157587. PMID: 27301021; PMCID: PMC4907476.
      5. Grimsey NJ, Trejo J. Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin. Curr Opin Hematol. 2016 May; 23(3):274-9. PMID: 26845544; PMCID: PMC4978167 [Available on 05/01/17].
      6. Grimsey NJ, Coronel LJ, Cordova IC, Trejo J. Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. J Biol Chem. 2016 Jan 29; 291(5):2223-36. PMID: 26635365; PMCID: PMC4732206 [Available on 01/29/17].
      7. Dores MR, Lin H, J Grimsey N, Mendez F, Trejo J. The a-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. Mol Biol Cell. 2015 Dec 15; 26(25):4660-73. PMID: 26490116; PMCID: PMC4678022.
      8. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. PMID: 26391660; PMCID: PMC4586747.
      9. Dores MR, Trejo J. GPCR sorting at multivesicular endosomes. Methods Cell Biol. 2015; 130:319-32. PMID: 26360043.
        View in: PubMed
      10. Soto AG, Smith TH, Chen B, Bhattacharya S, Cordova IC, Kenakin T, Vaidehi N, Trejo J. N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):E3600-8. PMID: 26100877; PMCID: PMC4500229.
      11. Stoner TD, Weston TA, Trejo J, Doran KS. Group B streptococcal infection and activation of human astrocytes. PLoS One. 2015; 10(6):e0128431. PMID: 26030618; PMCID: PMC4452173.
      12. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60. PMID: 26004360; PMCID: PMC4515213.
      13. Chen B, Soto AG, Coronel LJ, Goss A, van Ryn J, Trejo J. Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro. Mol Pharmacol. 2015 Jul; 88(1):95-105. PMID: 25934730; PMCID: PMC4468637.
      14. Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454. PMID: 24489642; PMCID: PMC3904831.
      15. Grimsey N, Lin H, Trejo J. Endosomal signaling by protease-activated receptors. Methods Enzymol. 2014; 535:389-401. PMID: 24377935; PMCID: PMC4085098.
      16. Dores MR, Trejo J. Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination. Curr Opin Cell Biol. 2014 Apr; 27:44-50. PMID: 24680429; PMCID: PMC4020713.
      17. Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. PMID: 24297163; PMCID: PMC3894338.
      18. Lin H, Liu AP, Smith TH, Trejo J. Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev. 2013; 65(4):1198-213. PMID: 24064459; PMCID: PMC3799237.
      19. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, ß-arrestin-mediated internalization. J Biol Chem. 2013 Nov 08; 288(45):32194-210. PMID: 24056371; PMCID: PMC3820859.
      20. Canto I, Trejo J. Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting. J Biol Chem. 2013 May 31; 288(22):15900-12. PMID: 23580642; PMCID: PMC3668746.
      21. Lin H, Trejo J. Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits ß-arrestin-mediated endosomal signaling. J Biol Chem. 2013 Apr 19; 288(16):11203-15. PMID: 23476015; PMCID: PMC3630854.
      22. Antoniak S, Owens AP, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N. PAR-1 contributes to the innate immune response during viral infection. J Clin Invest. 2013 Mar; 123(3):1310-22. PMID: 23391721; PMCID: PMC3582138.
      23. Marchese A, Trejo J. Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. Cell Signal. 2013 Mar; 25(3):707-16. PMID: 23201781; PMCID: PMC3593103.
      24. Canto I, Soh UJ, Trejo J. Allosteric modulation of protease-activated receptor signaling. Mini Rev Med Chem. 2012 Aug; 12(9):804-11. PMID: 22681248; PMCID: PMC4237590.
      25. Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J. AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. Mol Biol Cell. 2012 Sep; 23(18):3612-23. PMID: 22833563; PMCID: PMC3442409.
      26. Dores MR, Trejo J. Ubiquitination of G protein-coupled receptors: functional implications and drug discovery. Mol Pharmacol. 2012 Oct; 82(4):563-70. PMID: 22700696; PMCID: PMC3463220.
      27. Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T, Trejo J. ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J Cell Biol. 2012 Apr 30; 197(3):407-19. PMID: 22547407; PMCID: PMC3341166.
      28. Malik R, Soh UJ, Trejo J, Marchese A. Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012 Mar 16; 287(12):9013-27. PMID: 22275353; PMCID: PMC3308791.
      29. Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through ß-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):E1372-80. PMID: 22106258; PMCID: PMC3250136.
      30. Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J. Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals. J Biol Chem. 2011 Nov 25; 286(47):40760-70. PMID: 21965661; PMCID: PMC3220480.
      31. Grimsey N, Soto AG, Trejo J. Regulation of protease-activated receptor signaling by post-translational modifications. IUBMB Life. 2011 Jun; 63(6):403-11. PMID: 21438117; PMCID: PMC3121918.
      32. Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C654-64. PMID: 20573995; PMCID: PMC2944319.
      33. Soh UJ, Dores MR, Chen B, Trejo J. Signal transduction by protease-activated receptors. Br J Pharmacol. 2010 May; 160(2):191-203. PMID: 20423334; PMCID: PMC2874842.
      34. Soto AG, Trejo J. N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. J Biol Chem. 2010 Jun 11; 285(24):18781-93. PMID: 20368337; PMCID: PMC2881801.
      35. Ricks TK, Trejo J. Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J Biol Chem. 2009 Dec 04; 284(49):34444-57. PMID: 19815543; PMCID: PMC2797212.
      36. Seminario-Vidal L, Kreda S, Jones L, O'Neal W, Trejo J, Boucher RC, Lazarowski ER. Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem. 2009 Jul 31; 284(31):20638-48. PMID: 19439413; PMCID: PMC2742828.
      37. Russo A, Soh UJ, Trejo J. Proteases display biased agonism at protease-activated receptors: location matters! Mol Interv. 2009 Apr; 9(2):87-96. PMID: 19401541; PMCID: PMC3139377.
      38. Russo A, Soh UJ, Paing MM, Arora P, Trejo J. Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6393-7. PMID: 19332793; PMCID: PMC2669384.
      39. Arora P, Cuevas BD, Russo A, Johnson GL, Trejo J. Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. Oncogene. 2008 Jul 24; 27(32):4434-45. PMID: 18372913; PMCID: PMC2874884.
      40. Alam MR, Dixit V, Kang H, Li ZB, Chen X, Trejo J, Fisher M, Juliano RL. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res. 2008 May; 36(8):2764-76. PMID: 18367474; PMCID: PMC2377441.
      41. Marchese A, Paing MM, Temple BR, Trejo J. G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol. 2008; 48:601-29. PMID: 17995450; PMCID: PMC2869288.
      42. Bhandari D, Trejo J, Benovic JL, Marchese A. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21; 282(51):36971-9. PMID: 17947233.
        View in: PubMed
      43. Wolfe BL, Marchese A, Trejo J. Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol. 2007 Jun 04; 177(5):905-16. PMID: 17535965; PMCID: PMC2064289.
      44. Traynelis SF, Trejo J. Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol. 2007 May; 14(3):230-5. PMID: 17414212.
        View in: PubMed
      45. Wolfe BL, Trejo J. Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic. 2007 May; 8(5):462-70. PMID: 17376169.
        View in: PubMed
      46. Arora P, Ricks TK, Trejo J. Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. J Cell Sci. 2007 Mar 15; 120(Pt 6):921-8. PMID: 17344429.
        View in: PubMed
      47. Camerer E, Trejo J. Cryptic messages: is noncoagulant tissue factor reserved for cell signaling? Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14259-60. PMID: 16985001; PMCID: PMC1599949.
      48. Dho SE, Trejo J, Siderovski DP, McGlade CJ. Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell. 2006 Sep; 17(9):4142-55. PMID: 16837553; PMCID: PMC1593178.
      49. Paing MM, Johnston CA, Siderovski DP, Trejo J. Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol. 2006 Apr; 26(8):3231-42. PMID: 16581796; PMCID: PMC1446942.
      50. Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006 Mar; 17(3):1228-38. PMID: 16407403; PMCID: PMC1382312.
      51. Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res. 2006 Jan 01; 66(1):307-14. PMID: 16397244.
        View in: PubMed
      52. Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H. A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. J Cell Sci. 2005 Nov 15; 118(Pt 22):5291-304. PMID: 16263766.
        View in: PubMed
      53. Griffin CT, Trejo J, Magnuson T. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15173-7. PMID: 16214895; PMCID: PMC1257690.
      54. Trejo J. Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors. Mol Pharmacol. 2005 May; 67(5):1388-90. PMID: 15713849.
        View in: PubMed
      55. Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J. Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol. 2005 Jan; 67(1):78-87. PMID: 15475570.
        View in: PubMed
      56. Paing MM, Temple BR, Trejo J. A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization. J Biol Chem. 2004 May 21; 279(21):21938-47. PMID: 15023990.
        View in: PubMed
      57. Booden MA, Eckert LB, Der CJ, Trejo J. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol. 2004 Mar; 24(5):1990-9. PMID: 14966279; PMCID: PMC350540.
      58. Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004 May; 15(5):2143-55. PMID: 14978220; PMCID: PMC404011.
      59. Chen CH, Paing MM, Trejo J. Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10020-31. PMID: 14699102.
        View in: PubMed
      60. Trejo J. Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking. J Pharmacol Exp Ther. 2003 Nov; 307(2):437-42. PMID: 12966163.
        View in: PubMed
      61. Wang Y, Zhou Y, Szabo K, Haft CR, Trejo J. Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. Mol Biol Cell. 2002 Jun; 13(6):1965-76. PMID: 12058063; PMCID: PMC117618.
      62. Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J. beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. J Biol Chem. 2002 Jan 11; 277(2):1292-300. PMID: 11694535.
        View in: PubMed
      63. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65. PMID: 10893235.
        View in: PubMed
      64. Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21. PMID: 10590056.
        View in: PubMed
      65. Trejo J, Coughlin SR. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24. PMID: 9890984.
        View in: PubMed
      66. Trejo J, Hammes SR, Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702. PMID: 9811863; PMCID: PMC24882.
      67. Shapiro MJ, Trejo J, Zeng D, Coughlin SR. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80. PMID: 8955127.
        View in: PubMed
      68. Trejo J, Connolly AJ, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41. PMID: 8702939.
        View in: PubMed
      69. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 1996 May 01; 6(5):598-605. PMID: 8805275.
        View in: PubMed
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