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JoAnn Trejo

Title(s)Professor and Assistant Vice Chancellor of Faculty Affairs, Pharmacology
SchoolHealth Sciences
Phone858-246-0150
ORCID ORCID Icon0000-0003-4405-6228 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San DiegoM.B.A.2015Rady School of Management
    University of California, San DiegoPh.D.1992School of Medicine
    University of California, DavisB.S.1986Toxicology/Biochemistry
    Collapse Awards and Honors
    2019Society for the Advancement of Chicanos and Native Americans in Science Outstanding Mentor Award
    2017American Society for Cell Biology EE Just Award for Outstanding Scientific Achievement
    2016UC San Diego Inclusive Excellence Award
    2015American Society for Biochemistry and Molecular Biology Ruth Kirchstein Outstanding Scientist Award
    2014UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring
    2012Women Who Mean Business Award, San Diego Business Journal
    2006American Heart Association Established Investigator Award
    1995American Heart Association Scientist Career Development Grant Award
    1993University of California President’s Postdoctoral Fellowship Award

    Collapse Overview 
    Collapse Overview
    JoAnn Trejo (BS, UC Davis; PhD and MBA, UC San Diego) completed her postdoctoral fellowship at UC San Francisco and accepted her first faculty position at the University of North Carolina, Chapel Hill, in 2000. She was recruited to UC San Diego in 2008, and promoted to full professor with tenure in 2012. In 2014, she was appointed Vice Chair of the Department Pharmacology. JoAnn is best known for her discoveries on cell signaling by protease-activated G protein-coupled receptors. She has made numerous discoveries related to the regulation of cell signaling in vascular endothelial cells and breast cancer published in prominent journals. Her work has been continuously funded by the NIH, UC Tobacco-related Disease Research Program, Komen Foundation, and the American Heart Association (AHA) including the prestigious AHA Established Investigator Award. She is also a leader in the scientific community and elected by her peers to serve on Council of the American Society for Cell Biology and American Society for Biochemistry and Molecular Biology, as Chair of two Gordon Research Conferences and multiple NIH and HHMI Study Sections. She currently serves on the Board of Scientific Counselors for Basic Sciences for NCI.

    JoAnn is also an advocate for equity, diversity and inclusive excellence. She is a member of several educational training programs and active in various national committees aimed at increasing equity and inclusion of women and under-represented ethnic/racial groups in science. JoAnn is the director for the NIH/NIGMS Institutional Research and Academic Career Development Award (IRACDA) Postdoctoral Training Program at UC San Diego that aims to enhance the diversity of academia - 65% of the trainees have obtained tenure-track faculty positions at academic institutions. She received the UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring in 2014. In 2015, she became Associate Dean for Health Sciences Faculty Affairs, and in 2019 Assistant Vice Chancellor for Health Sciences Faculty Affairs where she has made great strides in developing and implementing strategies, programs and initiatives to enhance faculty success as well as to enhance the recruitment, retention and development of an engaged diverse faculty, and to support a climate of inclusive excellence. Under JoAnn's direction, the UCSD Health Sciences Office of Faculty Affairs received a HRSA-funded Hispanic Center of Excellence Award in 2017 and a NIH/NHLBI-supported Program to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE) in 2019 for faculty development.

    Collapse Research 
    Collapse Research Activities and Funding
    UCSD PRIDE Faculty Development Program in Cardiovascular Sciences
    NIH/NHLBI R25HL145817Feb 8, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Cell Signaling by Protease-activated G Protein-coupled Receptors
    NIH/NIGMS R35GM127121Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    GPCR Cytoprotective Signaling Mechanisms
    NIH/NIGMS R01GM116597Sep 1, 2015 - Jul 31, 2019
    Role: Principal Investigator
    2013 Molecular Pharmacology Gordon Research Conference and Gordon Research Semina
    NIH/NIDA R13DA035525Apr 24, 2013 - Mar 31, 2014
    Role: Principal Investigator
    Mechanisms Regulating GPCR Trafficking
    NIH/NIGMS R01GM090689Jan 1, 2010 - Dec 31, 2018
    Role: Principal Investigator
    Symposium on Extracellular and Membrane Proteases in Cell Signaling
    NIH/NCI R13CA135997Sep 4, 2008 - Aug 31, 2009
    Role: Principal Investigator
    San Diego IRACDA: Professors for the Future
    NIH/NIGMS K12GM068524Aug 1, 2003 - Jun 30, 2021
    Role: Principal Investigator
    Regulation of Protease-activated Receptor-1 Signaling
    NIH/NHLBI R01HL073328Apr 1, 2003 - Dec 31, 2013
    Role: Principal Investigator
    Molecular Mechanisms of PAR1 Downregulation
    NIH/NHLBI K01HL067697Apr 15, 2001 - Mar 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ochoa SD, Dores MR, Allen JM, Tran T, Osman M, Vázquez Castellanos NP, Trejo J, Zayas RM. A modular laboratory course using planarians to study genes involved in tissue regeneration. Biochem Mol Biol Educ. 2019 Sep; 47(5):547-559. PMID: 31194289.
      View in: PubMed
    2. Grimsey NJ, Lin Y, Narala R, Rada CC, Mejia-Pena H, Trejo J. G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem. 2019 04 12; 294(15):5867-5878. PMID: 30760523.
      View in: PubMed
    3. Dores MR, Trejo J. Endo-lysosomal sorting of G-protein-coupled receptors by ubiquitin: Diverse pathways for G-protein-coupled receptor destruction and beyond. Traffic. 2019 02; 20(2):101-109. PMID: 30353650.
      View in: PubMed
    4. Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep. 2018 09 18; 24(12):3312-3323.e5. PMID: 30232011.
      View in: PubMed
    5. Arakaki AKS, Pan WA, Trejo J. GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling. Int J Mol Sci. 2018 Jun 27; 19(7). PMID: 29954076.
      View in: PubMed
    6. Wingard D, Trejo J, Gudea M, Goodman S, Reznik V. Faculty Equity, Diversity, Culture and Climate Change in Academic Medicine: A Longitudinal Study. J Natl Med Assoc. 2019 Feb; 111(1):46-53. PMID: 30129483.
      View in: PubMed
    7. Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal. 2018 02 13; 11(517). PMID: 29440509.
      View in: PubMed
    8. Arakaki AKS, Pan WA, Lin H, Trejo J. The a-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling. J Biol Chem. 2018 03 02; 293(9):3350-3362. PMID: 29348172.
      View in: PubMed
    9. Trejo J. A reflection on faculty diversity in the 21st century. Mol Biol Cell. 2017 Nov 01; 28(22):2911-2914. PMID: 29084907.
      View in: PubMed
    10. Smith TH, Li JG, Dores MR, Trejo J. Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of ß-arrestin. J Biol Chem. 2017 08 18; 292(33):13867-13878. PMID: 28652403.
      View in: PubMed
    11. Hamilton JR, Trejo J. Challenges and Opportunities in Protease-Activated Receptor Drug Development. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:349-373. PMID: 27618736.
      View in: PubMed
    12. Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of ß-Arrestins. J Biol Chem. 2016 08 26; 291(35):18453-64. PMID: 27402844.
      View in: PubMed
    13. Dores MR, Grimsey NJ, Mendez F, Trejo J. ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif. PLoS One. 2016; 11(6):e0157587. PMID: 27301021.
      View in: PubMed
    14. Grimsey NJ, Trejo J. Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin. Curr Opin Hematol. 2016 May; 23(3):274-9. PMID: 26845544.
      View in: PubMed
    15. Grimsey NJ, Coronel LJ, Cordova IC, Trejo J. Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. J Biol Chem. 2016 Jan 29; 291(5):2223-36. PMID: 26635365.
      View in: PubMed
    16. Dores MR, Lin H, J Grimsey N, Mendez F, Trejo J. The a-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. Mol Biol Cell. 2015 Dec 15; 26(25):4660-73. PMID: 26490116.
      View in: PubMed
    17. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. PMID: 26391660.
      View in: PubMed
    18. Dores MR, Trejo J. GPCR sorting at multivesicular endosomes. Methods Cell Biol. 2015; 130:319-32. PMID: 26360043.
      View in: PubMed
    19. Soto AG, Smith TH, Chen B, Bhattacharya S, Cordova IC, Kenakin T, Vaidehi N, Trejo J. N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):E3600-8. PMID: 26100877.
      View in: PubMed
    20. Stoner TD, Weston TA, Trejo J, Doran KS. Group B streptococcal infection and activation of human astrocytes. PLoS One. 2015; 10(6):e0128431. PMID: 26030618.
      View in: PubMed
    21. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60. PMID: 26004360.
      View in: PubMed
    22. Chen B, Soto AG, Coronel LJ, Goss A, van Ryn J, Trejo J. Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro. Mol Pharmacol. 2015 Jul; 88(1):95-105. PMID: 25934730.
      View in: PubMed
    23. Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454. PMID: 24489642.
      View in: PubMed
    24. Grimsey N, Lin H, Trejo J. Endosomal signaling by protease-activated receptors. Methods Enzymol. 2014; 535:389-401. PMID: 24377935.
      View in: PubMed
    25. Dores MR, Trejo J. Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination. Curr Opin Cell Biol. 2014 Apr; 27:44-50. PMID: 24680429.
      View in: PubMed
    26. Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. PMID: 24297163.
      View in: PubMed
    27. Lin H, Liu AP, Smith TH, Trejo J. Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev. 2013; 65(4):1198-213. PMID: 24064459.
      View in: PubMed
    28. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, ß-arrestin-mediated internalization. J Biol Chem. 2013 Nov 08; 288(45):32194-210. PMID: 24056371.
      View in: PubMed
    29. Canto I, Trejo J. Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting. J Biol Chem. 2013 May 31; 288(22):15900-12. PMID: 23580642.
      View in: PubMed
    30. Lin H, Trejo J. Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits ß-arrestin-mediated endosomal signaling. J Biol Chem. 2013 Apr 19; 288(16):11203-15. PMID: 23476015.
      View in: PubMed
    31. Antoniak S, Owens AP, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N. PAR-1 contributes to the innate immune response during viral infection. J Clin Invest. 2013 Mar; 123(3):1310-22. PMID: 23391721.
      View in: PubMed
    32. Marchese A, Trejo J. Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. Cell Signal. 2013 Mar; 25(3):707-16. PMID: 23201781.
      View in: PubMed
    33. Canto I, Soh UJ, Trejo J. Allosteric modulation of protease-activated receptor signaling. Mini Rev Med Chem. 2012 Aug; 12(9):804-11. PMID: 22681248.
      View in: PubMed
    34. Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J. AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. Mol Biol Cell. 2012 Sep; 23(18):3612-23. PMID: 22833563.
      View in: PubMed
    35. Dores MR, Trejo J. Ubiquitination of G protein-coupled receptors: functional implications and drug discovery. Mol Pharmacol. 2012 Oct; 82(4):563-70. PMID: 22700696.
      View in: PubMed
    36. Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T, Trejo J. ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J Cell Biol. 2012 Apr 30; 197(3):407-19. PMID: 22547407.
      View in: PubMed
    37. Malik R, Soh UJ, Trejo J, Marchese A. Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012 Mar 16; 287(12):9013-27. PMID: 22275353.
      View in: PubMed
    38. Soh UJ, Trejo J. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through ß-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):E1372-80. PMID: 22106258.
      View in: PubMed
    39. Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J. Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals. J Biol Chem. 2011 Nov 25; 286(47):40760-70. PMID: 21965661.
      View in: PubMed
    40. Grimsey N, Soto AG, Trejo J. Regulation of protease-activated receptor signaling by post-translational modifications. IUBMB Life. 2011 Jun; 63(6):403-11. PMID: 21438117.
      View in: PubMed
    41. Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C654-64. PMID: 20573995.
      View in: PubMed
    42. Soh UJ, Dores MR, Chen B, Trejo J. Signal transduction by protease-activated receptors. Br J Pharmacol. 2010 May; 160(2):191-203. PMID: 20423334.
      View in: PubMed
    43. Soto AG, Trejo J. N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. J Biol Chem. 2010 Jun 11; 285(24):18781-93. PMID: 20368337.
      View in: PubMed
    44. Ricks TK, Trejo J. Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J Biol Chem. 2009 Dec 04; 284(49):34444-57. PMID: 19815543.
      View in: PubMed
    45. Seminario-Vidal L, Kreda S, Jones L, O'Neal W, Trejo J, Boucher RC, Lazarowski ER. Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem. 2009 Jul 31; 284(31):20638-48. PMID: 19439413.
      View in: PubMed
    46. Russo A, Soh UJ, Trejo J. Proteases display biased agonism at protease-activated receptors: location matters! Mol Interv. 2009 Apr; 9(2):87-96. PMID: 19401541.
      View in: PubMed
    47. Russo A, Soh UJ, Paing MM, Arora P, Trejo J. Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6393-7. PMID: 19332793.
      View in: PubMed
    48. Arora P, Cuevas BD, Russo A, Johnson GL, Trejo J. Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. Oncogene. 2008 Jul 24; 27(32):4434-45. PMID: 18372913.
      View in: PubMed
    49. Alam MR, Dixit V, Kang H, Li ZB, Chen X, Trejo J, Fisher M, Juliano RL. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res. 2008 May; 36(8):2764-76. PMID: 18367474.
      View in: PubMed
    50. Marchese A, Paing MM, Temple BR, Trejo J. G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol. 2008; 48:601-29. PMID: 17995450.
      View in: PubMed
    51. Bhandari D, Trejo J, Benovic JL, Marchese A. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21; 282(51):36971-9. PMID: 17947233.
      View in: PubMed
    52. Wolfe BL, Marchese A, Trejo J. Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol. 2007 Jun 04; 177(5):905-16. PMID: 17535965.
      View in: PubMed
    53. Traynelis SF, Trejo J. Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol. 2007 May; 14(3):230-5. PMID: 17414212.
      View in: PubMed
    54. Wolfe BL, Trejo J. Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic. 2007 May; 8(5):462-70. PMID: 17376169.
      View in: PubMed
    55. Arora P, Ricks TK, Trejo J. Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. J Cell Sci. 2007 Mar 15; 120(Pt 6):921-8. PMID: 17344429.
      View in: PubMed
    56. Camerer E, Trejo J. Cryptic messages: is noncoagulant tissue factor reserved for cell signaling? Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14259-60. PMID: 16985001.
      View in: PubMed
    57. Dho SE, Trejo J, Siderovski DP, McGlade CJ. Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell. 2006 Sep; 17(9):4142-55. PMID: 16837553.
      View in: PubMed
    58. Paing MM, Johnston CA, Siderovski DP, Trejo J. Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol. 2006 Apr; 26(8):3231-42. PMID: 16581796.
      View in: PubMed
    59. Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006 Mar; 17(3):1228-38. PMID: 16407403.
      View in: PubMed
    60. Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res. 2006 Jan 01; 66(1):307-14. PMID: 16397244.
      View in: PubMed
    61. Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H. A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. J Cell Sci. 2005 Nov 15; 118(Pt 22):5291-304. PMID: 16263766.
      View in: PubMed
    62. Griffin CT, Trejo J, Magnuson T. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15173-7. PMID: 16214895.
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    63. Trejo J. Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors. Mol Pharmacol. 2005 May; 67(5):1388-90. PMID: 15713849.
      View in: PubMed
    64. Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J. Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol. 2005 Jan; 67(1):78-87. PMID: 15475570.
      View in: PubMed
    65. Paing MM, Temple BR, Trejo J. A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization. J Biol Chem. 2004 May 21; 279(21):21938-47. PMID: 15023990.
      View in: PubMed
    66. Booden MA, Eckert LB, Der CJ, Trejo J. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol. 2004 Mar; 24(5):1990-9. PMID: 14966279.
      View in: PubMed
    67. Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004 May; 15(5):2143-55. PMID: 14978220.
      View in: PubMed
    68. Chen CH, Paing MM, Trejo J. Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10020-31. PMID: 14699102.
      View in: PubMed
    69. Trejo J. Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking. J Pharmacol Exp Ther. 2003 Nov; 307(2):437-42. PMID: 12966163.
      View in: PubMed
    70. Wang Y, Zhou Y, Szabo K, Haft CR, Trejo J. Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. Mol Biol Cell. 2002 Jun; 13(6):1965-76. PMID: 12058063.
      View in: PubMed
    71. Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J. beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. J Biol Chem. 2002 Jan 11; 277(2):1292-300. PMID: 11694535.
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    72. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65. PMID: 10893235.
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    73. Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21. PMID: 10590056.
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    74. Trejo J, Coughlin SR. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24. PMID: 9890984.
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    75. Trejo J, Hammes SR, Coughlin SR. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702. PMID: 9811863.
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    76. Shapiro MJ, Trejo J, Zeng D, Coughlin SR. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80. PMID: 8955127.
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    77. Trejo J, Connolly AJ, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41. PMID: 8702939.
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    78. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 1996 May 01; 6(5):598-605. PMID: 8805275.
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    79. Trejo J, Massamiri T, Deng T, Dewji NN, Bayney RM, Brown JH. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. PMID: 8063812.
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    80. Trejo J, Chambard JC, Karin M, Brown JH. Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol. 1992 Oct; 12(10):4742-50. PMID: 1328861.
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    81. Trejo J, Brown JH. c-fos and c-jun are induced by muscarinic receptor activation of protein kinase C but are differentially regulated by intracellular calcium. J Biol Chem. 1991 Apr 25; 266(12):7876-82. PMID: 1902229.
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    82. Brown JH, Trilivas I, Trejo J, Martinson E. Multiple pathways for signal transduction through the muscarinic cholinergic receptor. Prog Brain Res. 1990; 84:21-9. PMID: 2267298.
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