Joann Trejo

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0003-4405-6228 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, Rady School of ManagementM.B.A.2015Leadership, Finance, Management
    University of California, San Diego, School of MedicinePh.D.1992Physiology, Pharmacology
    University of California, DavisB.S.1986Toxicology, Biochemistry
    Collapse Awards and Honors
    Elected Member2021National Academy of Medicine
    Elected Fellow2020American Society for Cell Biology Fellow
    Elected2020100 Inspiring Latinx/Hispanic Scientists | Cell Press
    2020American Society for Cell Biology Prize for Excellence in Inclusivity
    2019Society for the Advancement of Chicanos and Native Americans in Science Outstanding Mentor Award
    2017American Society for Cell Biology EE Just Award for Outstanding Scientific Achievement
    2016UC San Diego Inclusive Excellence Award
    2015American Society for Biochemistry and Molecular Biology Ruth Kirchstein Outstanding Scientist Award
    2014UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring
    2012Women Who Mean Business Award, San Diego Business Journal
    2006American Heart Association Established Investigator Award
    1995American Heart Association Scientist Career Development Grant Award
    1993University of California President’s Postdoctoral Fellowship Award

    Collapse Overview 
    Collapse Overview
    JoAnn Trejo, PhD, MBA is a professor of Pharmacology in the School of Medicine, UC San Diego. She completed her postdoctoral training at UC San Francisco and was appointed assistant professor at the University of North Carolina, Chapel Hill, in 2000. She was recruited to UC San Diego as a tenured faculty in 2008 and promoted to full professor in 2012. In 2014, she was appointed vice chair of the Department Pharmacology. Dr. Trejo is best known for her discoveries of how cellular responses are regulated by G protein-coupled receptors in the context of vascular inflammation and cancer. She has made numerous novel discoveries related to the regulation of cell signaling in endothelial dysfunction and breast cancer progression. Her work has been published in >100 peer-reviewed articles. She has been continuously funded by the NIH including a R35 Outstanding Investigator Award, she also received support from the UC Tobacco-related Disease Research Program, Susan G. Komen Breast Cancer Foundation, and the American Heart Association.

    Dr. Trejo is a leader in the scientific community and was elected by her peers to serve on Council of the American Society for Cell Biology and American Society for Biochemistry and Molecular Biology, as Chair of two Gordon Research Conferences and multiple NIH and HHMI Study Sections. She currently serves on the National Cancer Institute (NCI) Board of Scientific Counselors for Basic Sciences. She has been recognized with the prestigious American Heart Association Established Investigator Award, American Society for Biochemistry and Molecular Biology Ruth Kirschstein Outstanding Scientist Award and the American Society for Cell Biology EE Just Award for Outstanding Scientific Achievement. She was named to Cell Mentor’s list of 100 Inspiring Hispanic/Latinx Scientists in America and Fellow of the American Society for Cell Biology in 2020. Dr. Trejo was elected to the National Academy of Medicine in 2021.

    Dr. Trejo is held in high regard as a mentor, educator and leader engaged in numerous initiatives aimed at enhancing inclusive excellence. She has trained 85 scientists, 53 are women and 44 are underrepresented racial / ethnic trainees and all have transitioned to excellent positions in science. She is active in several training programs and national committees aimed at increasing diversity of the biomedical workforce. She is the director of the NIH/NIGMS Institutional Research and Academic Career Development Award (IRACDA) Postdoctoral Training Program at UC San Diego. SD IRACDA has trained 114 postdoctoral scholars - 65% of the trainees have obtained tenure-track faculty positions at academic institutions. She received the UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring in 2014 and the American Society for Cell Biology Inclusive Excellence Award in 2020.

    In 2015, Dr. Trejo was appointed associate dean for Health Sciences Faculty Affairs, and promoted to assistant vice chancellor for Health Sciences Faculty Affairs in 2019. She has made great strides in developing effective strategies, programs and initiatives to enhance faculty success and recruitment, retention and development of an engaged diverse faculty, and to support a climate of inclusive excellence. Under her direction, the UCSD Health Sciences Office of Faculty Affairs developed and implemented the Health Sciences Faculty Mentor Training Program, Grant Writing Course and received multiple extramural awards for faculty development including a HRSA-funded Hispanic Center of Excellence Award in 2017, NIH-supported NHLBI PRIDE Future Faculty of Cardiovascular Sciences (FOCUS) in 2019, NINDS Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) in 2020, NIAID Raising Advancement and Parity for Infectious Disease Researchers (RAPID) in 2020, NIGMS Building a Respectful, Inclusive Culture (BRIC) in 2022 and an NIH/NCI FIRST Award in 2022.

    JoAnn Trejo was born in French Camp, San Joaquin County and raised in Stockton, Calif. She earned her bachelor’s degree at UC Davis, her PhD at UC San Diego School of Medicine and MBA from the Rady School of Management at UC San Diego.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    UC San Diego RAPID Faculty Development Program in Infectious Diseases
    NIH R25AI147376Aug 10, 2020 - Jul 31, 2025
    Role: Principal Investigator
    San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Program
    NIH R25NS117367Aug 1, 2020 - Jul 31, 2025
    Role: Principal Investigator
    UCSD PRIDE Faculty Development Program in Cardiovascular Sciences
    NIH R25HL145817Feb 8, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Cell Signaling by Protease-activated G Protein-coupled Receptors
    NIH R35GM127121Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    GPCR Cytoprotective Signaling Mechanisms
    NIH R01GM116597Sep 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    2013 Molecular Pharmacology Gordon Research Conference and Gordon Research Semina
    NIH R13DA035525Apr 24, 2013 - Mar 31, 2014
    Role: Principal Investigator
    Mechanisms Regulating GPCR Trafficking
    NIH R01GM090689Jan 1, 2010 - Dec 31, 2018
    Role: Principal Investigator
    Symposium on Extracellular and Membrane Proteases in Cell Signaling
    NIH R13CA135997Sep 4, 2008 - Aug 31, 2009
    Role: Principal Investigator
    San Diego IRACDA Scholars Program
    NIH K12GM068524Aug 1, 2003 - Jun 30, 2026
    Role: Principal Investigator
    Regulation of Protease-activated Receptor-1 Signaling
    NIH R01HL073328Apr 1, 2003 - Dec 31, 2013
    Role: Principal Investigator
    Molecular Mechanisms of PAR1 Downregulation
    NIH K01HL067697Apr 15, 2001 - Mar 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phosphoproteomic analysis of thrombin- and p38 MAPK-regulated signaling networks in endothelial cells. J Biol Chem. 2022 04; 298(4):101801. Molinar-Inglis O, Wozniak JM, Grimsey NJ, Orduña-Castillo LB, Cheng N, Lin Y, Gonzalez Ramirez ML, Birch CA, Lapek JD, Gonzalez DJ, Trejo J. PMID: 35257745; PMCID: PMC8987612.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The α-Arrestin ARRDC3 Is an Emerging Multifunctional Adaptor Protein in Cancer. Antioxid Redox Signal. 2022 05; 36(13-15):1066-1079. Wedegaertner H, Pan WA, Gonzalez CC, Gonzalez DJ, Trejo J. PMID: 34465145; PMCID: PMC9127825.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    3. A system-wide health sciences faculty mentor training program is associated with improved effective mentoring and institutional climate. J Clin Transl Sci. 2022; 6(1):e18. Trejo J, Wingard D, Hazen V, Bortnick A, Van Hoesen K, Byars-Winston A, Pfund C, Reznik V. PMID: 35291213; PMCID: PMC8889225.
      View in: PubMed   Mentions:
    4. aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 2021 12 07; 118(49). Molinar-Inglis O, Birch CA, Nicholas D, Orduña-Castillo L, Cisneros-Aguirre M, Patwardhan A, Chen B, Grimsey NJ, Coronel LJ, Lin H, Gomez Menzies PK, Lawson MA, Patel HH, Trejo J. PMID: 34873055; PMCID: PMC8670512.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption. Sci Signal. 2021 Aug 31; 14(698):eabc1044. Rada CC, Mejia-Pena H, Grimsey NJ, Canto Cordova I, Olson J, Wozniak JM, Gonzalez DJ, Nizet V, Trejo J. PMID: 34516752; PMCID: PMC8538426.
      View in: PubMed   Mentions: 1     Fields:    
    6. α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. J Cell Sci. 2021 04 15; 134(8). Arakaki AKS, Pan WA, Wedegaertner H, Roca-Mercado I, Chinn L, Gujral TS, Trejo J. PMID: 33722977; PMCID: PMC8084569.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    7. Post-Translational Modifications of G Protein-Coupled Receptors Control Cellular Signaling Dynamics in Space and Time. Pharmacol Rev. 2021 01; 73(1):120-151. Patwardhan A, Cheng N, Trejo J. PMID: 33268549; PMCID: PMC7736832.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    8. The burden of service for faculty of color to achieve diversity and inclusion: the minority tax. Mol Biol Cell. 2020 12 01; 31(25):2752-2754. Trejo J. PMID: 33253072; PMCID: PMC7851863.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nat Commun. 2020 11 30; 11(1):6088. Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. PMID: 33257668; PMCID: PMC7705703.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Subcellular hot spots of GPCR signaling promote vascular inflammation. Curr Opin Endocr Metab Res. 2021 Feb; 16:37-42. Birch CA, Molinar-Inglis O, Trejo J. PMID: 32838054; PMCID: PMC7431397.
      View in: PubMed   Mentions: 10  
    11. GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. Sci Rep. 2020 08 03; 10(1):13063. Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman AS, Mellon PL, Lawson MA. PMID: 32747664; PMCID: PMC7400764.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. Elife. 2020 05 26; 9. Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J. PMID: 32452765; PMCID: PMC7289600.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    13. Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):5039-5048. Lin Y, Wozniak JM, Grimsey NJ, Girada S, Patwardhan A, Molinar-Inglis O, Smith TH, Lapek JD, Gonzalez DJ, Trejo J. PMID: 32071217; PMCID: PMC7060683.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. Endo-lysosomal sorting of G protein-coupled receptors by ubiquitin: Diverse pathways for GPCR destruction and beyond . Traffic. 2019; 20(2):101-109. M. R. Dores, J. Trejo. .
    15. A modular laboratory course using planarians to study genes involved in tissue regeneration. Biochem. and Mol. Biol. Education. 2019; 47(5):547-559. S.D. Ochoa, M.R. Dores, J.M. Allen, T. Tran, M. Osman, N.P. Vazquez-Castellanos, J. Trejo, R. Zayas.
    16. G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem. 2019 04 12; 294(15):5867-5878. Grimsey NJ, Lin Y, Narala R, Rada CC, Mejia-Pena H, Trejo J. PMID: 30760523; PMCID: PMC6463731.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    17. The alpha-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling. J. Biol. Chem. 2018; 293:3350-3362. A.K.S. Arakaki, W.A. Pan, H. Lin, J. Trejo. .
    18. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep. 2018 09 18; 24(12):3312-3323.e5. Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. PMID: 30232011; PMCID: PMC6226018.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    19. GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling. Int J Mol Sci. 2018 Jun 27; 19(7). Arakaki AKS, Pan WA, Trejo J. PMID: 29954076; PMCID: PMC6073120.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    20. Faculty Equity, Diversity, Culture and Climate Change in Academic Medicine: A Longitudinal Study. J Natl Med Assoc. 2019 Feb; 111(1):46-53. Wingard D, Trejo J, Gudea M, Goodman S, Reznik V. PMID: 30129483.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci Signal. 2018 02 13; 11(517). Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH. PMID: 29440509; PMCID: PMC5957084.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    22. A reflection on faculty diversity in the 21st century. Mol Biol Cell. 2017 Nov 01; 28(22):2911-2914. Trejo J. PMID: 29084907; PMCID: PMC5662248.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins. J Biol Chem. 2016 08 26; 291(35):18453-64. Smith TH, Coronel LJ, Li JG, Dores MR, Nieman MT, Trejo J. PMID: 27402844; PMCID: PMC5000090.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif. PLoS One. 2016; 11(6):e0157587. Dores MR, Grimsey NJ, Mendez F, Trejo J. PMID: 27301021; PMCID: PMC4907476.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    25. Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin. Curr Opin Hematol. 2016 May; 23(3):274-9. Grimsey NJ, Trejo J. PMID: 26845544; PMCID: PMC4978167.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. J Biol Chem. 2016 Jan 29; 291(5):2223-36. Grimsey NJ, Coronel LJ, Cordova IC, Trejo J. PMID: 26635365; PMCID: PMC4732206.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    27. The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. Mol Biol Cell. 2015 Dec 15; 26(25):4660-73. Dores MR, Lin H, J Grimsey N, Mendez F, Trejo J. PMID: 26490116; PMCID: PMC4678022.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    28. Chapter 20, GPCR Sorting at Multivesicular Endosomes. Methods in Cell Biology – Sorting and Recycling Endosomes. 2015; 130:319-332. M. R. Dores, J. Trejo. .
    29. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. PMID: 26391660; PMCID: PMC4586747.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    30. GPCR sorting at multivesicular endosomes. Methods Cell Biol. 2015; 130:319-32. Dores MR, Trejo J. PMID: 26360043; PMCID: PMC6215325.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):E3600-8. Soto AG, Smith TH, Chen B, Bhattacharya S, Cordova IC, Kenakin T, Vaidehi N, Trejo J. PMID: 26100877; PMCID: PMC4500229.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    32. Group B streptococcal infection and activation of human astrocytes. PLoS One. 2015; 10(6):e0128431. Stoner TD, Weston TA, Trejo J, Doran KS. PMID: 26030618; PMCID: PMC4452173.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    33. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. PMID: 26004360; PMCID: PMC4515213.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    34. Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro. Mol Pharmacol. 2015 Jul; 88(1):95-105. Chen B, Soto AG, Coronel LJ, Goss A, van Ryn J, Trejo J. PMID: 25934730; PMCID: PMC4468637.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    35. Imagining Possibilities (ed. L. Bridges). Open a World of Possible. Real Stories About the Power and Joy of Reading . 2014; 56-57. J. Trejo. .
    36. A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454. Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. PMID: 24489642; PMCID: PMC3904831.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Endosomal signaling by protease-activated receptors. Methods Enzymol. 2014; 535:389-401. Grimsey N, Lin H, Trejo J. PMID: 24377935; PMCID: PMC4085098.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    38. Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitination. Curr Opin Cell Biol. 2014 Apr; 27:44-50. Dores MR, Trejo J. PMID: 24680429; PMCID: PMC4020713.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    39. Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins. J Biol Chem. 2014 Jan 17; 289(3):1580-91. Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. PMID: 24297163; PMCID: PMC3894338.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev. 2013; 65(4):1198-213. Lin H, Liu AP, Smith TH, Trejo J. PMID: 24064459; PMCID: PMC3799237.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    41. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization. J Biol Chem. 2013 Nov 08; 288(45):32194-32210. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. PMID: 24056371; PMCID: PMC3820859.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    42. Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting. J Biol Chem. 2013 May 31; 288(22):15900-12. Canto I, Trejo J. PMID: 23580642; PMCID: PMC3668746.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    43. Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling. J Biol Chem. 2013 Apr 19; 288(16):11203-15. Lin H, Trejo J. PMID: 23476015; PMCID: PMC3630854.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    44. PAR-1 contributes to the innate immune response during viral infection. J Clin Invest. 2013 Mar; 123(3):1310-22. Antoniak S, Owens AP, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N. PMID: 23391721; PMCID: PMC3582138.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    45. Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. Cell Signal. 2013 Mar; 25(3):707-16. Marchese A, Trejo J. PMID: 23201781; PMCID: PMC3593103.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    46. Allosteric modulation of protease-activated receptor signaling. Mini Rev Med Chem. 2012 Aug; 12(9):804-11. Canto I, Soh UJ, Trejo J. PMID: 22681248; PMCID: PMC4237590.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. Mol Biol Cell. 2012 Sep; 23(18):3612-23. Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J. PMID: 22833563; PMCID: PMC3442409.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    48. Ubiquitination of G protein-coupled receptors: functional implications and drug discovery. Mol Pharmacol. 2012 Oct; 82(4):563-70. Dores MR, Trejo J. PMID: 22700696; PMCID: PMC3463220.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    49. ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J Cell Biol. 2012 Apr 30; 197(3):407-19. Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T, Trejo J. PMID: 22547407; PMCID: PMC3341166.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    50. Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012 Mar 16; 287(12):9013-27. Malik R, Soh UJ, Trejo J, Marchese A. PMID: 22275353; PMCID: PMC3308791.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    51. Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):E1372-80. Soh UJ, Trejo J. PMID: 22106258; PMCID: PMC3250136.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    52. Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals. J Biol Chem. 2011 Nov 25; 286(47):40760-70. Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J. PMID: 21965661; PMCID: PMC3220480.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    53. Regulation of protease-activated receptor signaling by post-translational modifications. IUBMB Life. 2011 Jun; 63(6):403-11. Grimsey N, Soto AG, Trejo J. PMID: 21438117; PMCID: PMC3121918.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    54. Chapter 5, Dysregulation of G Protein-Coupled Receptor Signaling in Cancer. (eds A. Sitaramayya) . Signal Transduction: Pathways, Mechanisms and Diseases. 2010; 83-98. J. Trejo. .
    55. RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C654-64. Laroche G, Giguère PM, Roth BL, Trejo J, Siderovski DP. PMID: 20573995; PMCID: PMC2944319.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    56. Signal transduction by protease-activated receptors. Br J Pharmacol. 2010 May; 160(2):191-203. Soh UJ, Dores MR, Chen B, Trejo J. PMID: 20423334; PMCID: PMC2874842.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    57. N-linked glycosylation of protease-activated receptor-1 second extracellular loop: a critical determinant for ligand-induced receptor activation and internalization. J Biol Chem. 2010 Jun 11; 285(24):18781-93. Soto AG, Trejo J. PMID: 20368337; PMCID: PMC2881801.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    58. Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. J Biol Chem. 2009 Dec 04; 284(49):34444-57. Ricks TK, Trejo J. PMID: 19815543; PMCID: PMC2797212.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    59. Chapter 3, Regulation of Thrombin Receptor Signaling (eds. M. E. Maragoudakis and N. E. Tsopanoglou). Thrombin: Physiology and Disease. 2009; 47-61. J. Trejo. .
    60. Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem. 2009 Jul 31; 284(31):20638-48. Seminario-Vidal L, Kreda S, Jones L, O'Neal W, Trejo J, Boucher RC, Lazarowski ER. PMID: 19439413; PMCID: PMC2742828.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    61. Proteases display biased agonism at protease-activated receptors: location matters! Mol Interv. 2009 Apr; 9(2):87-96. Russo A, Soh UJ, Trejo J. PMID: 19401541; PMCID: PMC3139377.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    62. Caveolae are required for protease-selective signaling by protease-activated receptor-1. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6393-7. Russo A, Soh UJ, Paing MM, Arora P, Trejo J. PMID: 19332793; PMCID: PMC2669384.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    63. Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. Oncogene. 2008 Jul 24; 27(32):4434-45. Arora P, Cuevas BD, Russo A, Johnson GL, Trejo J. PMID: 18372913; PMCID: PMC2874884.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    64. Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res. 2008 May; 36(8):2764-76. Alam MR, Dixit V, Kang H, Li ZB, Chen X, Trejo J, Fisher M, Juliano RL. PMID: 18367474; PMCID: PMC2377441.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    65. G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol. 2008; 48:601-29. Marchese A, Paing MM, Temple BR, Trejo J. PMID: 17995450; PMCID: PMC2869288.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansCells
    66. Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. J Biol Chem. 2007 Dec 21; 282(51):36971-9. Bhandari D, Trejo J, Benovic JL, Marchese A. PMID: 17947233.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    67. Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol. 2007 Jun 04; 177(5):905-16. Wolfe BL, Marchese A, Trejo J. PMID: 17535965; PMCID: PMC2064289.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    68. Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol. 2007 May; 14(3):230-5. Traynelis SF, Trejo J. PMID: 17414212.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    69. Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic. 2007 May; 8(5):462-70. Wolfe BL, Trejo J. PMID: 17376169.
      View in: PubMed   Mentions: 108     Fields:    
    70. Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer. J Cell Sci. 2007 Mar 15; 120(Pt 6):921-8. Arora P, Ricks TK, Trejo J. PMID: 17344429.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    71. Cryptic messages: is noncoagulant tissue factor reserved for cell signaling? Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14259-60. Camerer E, Trejo J. PMID: 16985001; PMCID: PMC1599949.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    72. Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane. Mol Biol Cell. 2006 Sep; 17(9):4142-55. Dho SE, Trejo J, Siderovski DP, McGlade CJ. PMID: 16837553; PMCID: PMC1593178.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    73. Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol. 2006 Apr; 26(8):3231-42. Paing MM, Johnston CA, Siderovski DP, Trejo J. PMID: 16581796; PMCID: PMC1446942.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    74. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006 Mar; 17(3):1228-38. Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J. PMID: 16407403; PMCID: PMC1382312.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    75. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res. 2006 Jan 01; 66(1):307-14. Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J. PMID: 16397244.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    76. A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. J Cell Sci. 2005 Nov 15; 118(Pt 22):5291-304. Urs NM, Jones KT, Salo PD, Severin JE, Trejo J, Radhakrishna H. PMID: 16263766.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    77. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15173-7. Griffin CT, Trejo J, Magnuson T. PMID: 16214895; PMCID: PMC1257690.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    78. Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors. Mol Pharmacol. 2005 May; 67(5):1388-90. Trejo J. PMID: 15713849.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    79. Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. Mol Pharmacol. 2005 Jan; 67(1):78-87. Stalheim L, Ding Y, Gullapalli A, Paing MM, Wolfe BL, Morris DR, Trejo J. PMID: 15475570.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    80. A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization. J Biol Chem. 2004 May 21; 279(21):21938-47. Paing MM, Temple BR, Trejo J. PMID: 15023990.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    81. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol. 2004 Mar; 24(5):1990-9. Booden MA, Eckert LB, Der CJ, Trejo J. PMID: 14966279; PMCID: PMC350540.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    82. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004 May; 15(5):2143-55. Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J. PMID: 14978220; PMCID: PMC404011.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    83. Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation. J Biol Chem. 2004 Mar 12; 279(11):10020-31. Chen CH, Paing MM, Trejo J. PMID: 14699102.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    84. Protease-activated receptors: new concepts in regulation of G protein-coupled receptor signaling and trafficking. J Pharmacol Exp Ther. 2003 Nov; 307(2):437-42. Trejo J. PMID: 12966163.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    85. Beta-arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation. J. Biol. Chem. 2002; 277:1292-1300. M.M. Paing, A. B. Stutts, T.A. Kohout, R. J. Lefkowitz, J. Trejo. .
    86. Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. . Mol. Biol. Cell. 2002; 13:1965-1976. Y. Wang, Y. Zhou, K. Szabo, C.R. Haft, J. Trejo. .
    87. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. PMID: 10893235.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    88. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21. Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. PMID: 10590056.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    89. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24. Trejo J, Coughlin SR. PMID: 9890984.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    90. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702. Trejo J, Hammes SR, Coughlin SR. PMID: 9811863; PMCID: PMC24882.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    91. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80. Shapiro MJ, Trejo J, Zeng D, Coughlin SR. PMID: 8955127.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    92. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41. Trejo J, Connolly AJ, Coughlin SR. PMID: 8702939.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    93. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 1996 May 01; 6(5):598-605. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. PMID: 8805275.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    94. A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem. 1994 Aug 26; 269(34):21682-90. Trejo J, Massamiri T, Deng T, Dewji NN, Bayney RM, Brown JH. PMID: 8063812.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    95. Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol. 1992 Oct; 12(10):4742-50. Trejo J, Chambard JC, Karin M, Brown JH. PMID: 1328861; PMCID: PMC360401.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    96. c-fos and c-jun are induced by muscarinic receptor activation of protein kinase C but are differentially regulated by intracellular calcium. J Biol Chem. 1991 Apr 25; 266(12):7876-82. Trejo J, Brown JH. PMID: 1902229.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    97. Multiple pathways for signal transduction through the muscarinic cholinergic receptor. Prog Brain Res. 1990; 84:21-9. Brown JH, Trilivas I, Trejo J, Martinson E. PMID: 2267298.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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