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Brian Spencer
Title
Associate Project Scientist
School
University of California, San Diego
Department
Neurosciences
Address
9500 Gilman Drive #0624
CA La Jolla 92093
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Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Fields JA, Metcalf J, Overk C, Adame A,
Spencer B
, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 Apr; 23(2):290-303. PMID: 28105557.
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PubMed
Spencer B
, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E. Anti-a-synuclein immunotherapy reduces a-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 Jan 13; 5(1):7. PMID: 28086964.
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PubMed
Valera E,
Spencer B
, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 Jan 05; 5(1):2. PMID: 28057080.
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PubMed
Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL,
Spencer B
, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. A de novo compound targeting a-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 Dec; 139(Pt 12):3217-3236. PMID: 27679481.
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PubMed
Spencer B
, Williams S, Rockenstein E, Valera E, Xin W, Mante M, Florio J, Adame A, Masliah E, Sierks MR. a-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease. Ann Clin Transl Neurol. 2016 Aug; 3(8):588-606. PMID: 27606342; PMCID: PMC4999592.
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PubMed
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PubMed Central
Wei C,
Spencer B
. Asymmetric shape transitions of epitaxial quantum dots. Proc Math Phys Eng Sci. 2016 Jun; 472(2190):20160262. PMID: 27436989.
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PubMed
Rockenstein E, Clarke J, Viel C, Panarello N, Treleaven CM, Kim C,
Spencer B
, Adame A, Park H, Dodge JC, Cheng SH, Shihabuddin LS, Masliah E, Sardi SP. Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease. Hum Mol Genet. 2016 Jul 01; 25(13):2645-2660. PMID: 27126635.
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PubMed
Kim C, Ojo-Amaize E,
Spencer B
, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. Hypoestoxide reduces neuroinflammation and a-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236. PMID: 26683203; PMCID: PMC4683943.
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PubMed
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PubMed Central
Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A,
Spencer B
, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. PMID: 26611103; PMCID: PMC4713337.
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PubMed
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PubMed Central
Kim C, Rockenstein E,
Spencer B
, Kim HK, Adame A, Trejo M, Stafa K, Lee HJ, Lee SJ, Masliah E. Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Rep. 2015 Oct 27; 13(4):771-782. PMID: 26489461; PMCID: PMC4752835.
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PubMed
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PubMed Central
Spencer B
, Valera E, Rockenstein E, Trejo-Morales M, Adame A, Masliah E. A brain-targeted, modified neurosin (kallikrein-6) reduces a-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener. 2015 Sep 23; 10:48. PMID: 26394760; PMCID: PMC4580347.
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PubMed
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PubMed Central
Rockenstein E, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Bisquert A, Trejo-Morales M,
Spencer B
, Masliah E. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015; 10(3):e0121570. PMID: 25803611; PMCID: PMC4372415.
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PubMed
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PubMed Central
Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M,
Spencer B
, Kosberg K, Masliah E. Molecular determinants of a-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. PMID: 25561023; PMCID: PMC4944825.
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PubMed
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PubMed Central
Masliah E,
Spencer B
. Applications of ApoB LDLR-Binding Domain Approach for the Development of CNS-Penetrating Peptides for Alzheimer's Disease. Methods Mol Biol. 2015; 1324:331-7. PMID: 26202279; PMCID: PMC4928629.
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PubMed
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PubMed Central
Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, Duarte S, Esau CC,
Spencer B
, Ashe TD, Fischer KM, MacKenna DA, Sopher BL, Masliah E, Gaasterland T, Chau BN, Pereira de Almeida L, Morrison BE, La Spada AR. Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. Cell Metab. 2014 Oct 07; 20(4):626-38. PMID: 25295787; PMCID: PMC4245205.
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PubMed
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PubMed Central
Spencer B
, Masliah E. Immunotherapy for Alzheimer's disease: past, present and future. Front Aging Neurosci. 2014; 6:114. PMID: 24959143; PMCID: PMC4051211.
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PubMed
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PubMed Central
Fields J, Dumaop W, Rockenstein E, Mante M,
Spencer B
, Grant I, Ellis R, Letendre S, Patrick C, Adame A, Masliah E. Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol. 2013 Feb; 19(1):89-101. PMID: 23341224; PMCID: PMC3567331.
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PubMed
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PubMed Central
Desplats P,
Spencer B
, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. a-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. J Biol Chem. 2012 Sep 14; 287(38):31691-702. PMID: 22833673; PMCID: PMC3442504.
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PubMed
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PubMed Central
Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C,
Spencer B
, Desplats P, Dale AM, Devor A, Masliah E. In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. J Neurosci. 2012 Jul 18; 32(29):9992-8. PMID: 22815513; PMCID: PMC3491088.
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PubMed
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PubMed Central
Spencer B
, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, Adame A, Masliah E. Lentivirus mediated delivery of neurosin promotes clearance of wild-type a-synuclein and reduces the pathology in an a-synuclein model of LBD. Mol Ther. 2013 Jan; 21(1):31-41. PMID: 22508489; PMCID: PMC3538325.
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PubMed
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PubMed Central
Cartier AE, Ubhi K,
Spencer B
, Vazquez-Roque RA, Kosberg KA, Fourgeaud L, Kanayson P, Patrick C, Rockenstein E, Patrick GN, Masliah E. Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. PLoS One. 2012; 7(4):e34713. PMID: 22514658; PMCID: PMC3326048.
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PubMed
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PubMed Central
Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L,
Spencer B
, Masliah E. Role of a-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. PMID: 22251432; PMCID: PMC3925782.
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PubMed
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PubMed Central
Ubhi K, Inglis C, Mante M, Patrick C, Adame A,
Spencer B
, Rockenstein E, May V, Winkler J, Masliah E. Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of a-synucleinopathy. Exp Neurol. 2012 Apr; 234(2):405-16. PMID: 22281106; PMCID: PMC3897235.
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PubMed
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PubMed Central
Masliah E, Rockenstein E, Mante M, Crews L,
Spencer B
, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One. 2011 Apr 29; 6(4):e19338. PMID: 21559417; PMCID: PMC3084838.
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PubMed
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PubMed Central
Desplats P,
Spencer B
, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem. 2011 Mar 18; 286(11):9031-7. PMID: 21296890; PMCID: PMC3059002.
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PubMed
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PubMed Central
Spencer B
, Marr RA, Gindi R, Potkar R, Michael S, Adame A, Rockenstein E, Verma IM, Masliah E. Peripheral delivery of a CNS targeted, metalo-protease reduces aß toxicity in a mouse model of Alzheimer's disease. PLoS One. 2011 Jan 31; 6(1):e16575. PMID: 21304989; PMCID: PMC3031588.
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PubMed
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PubMed Central
Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A,
Spencer B
, Patrick C, Desplats P, Ellisman MH, Masliah E. Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. PLoS One. 2010 Nov 16; 5(11):e14020. PMID: 21103359; PMCID: PMC2982819.
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PubMed
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PubMed Central
Marr RA,
Spencer B
. NEP-like endopeptidases and Alzheimer's disease [corrected]. Curr Alzheimer Res. 2010 May; 7(3):223-9. PMID: 20088804.
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PubMed
Crews L,
Spencer B
, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One. 2010 Feb 19; 5(2):e9313. PMID: 20174468; PMCID: PMC2824828.
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PubMed Central
Spencer B
, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci. 2009 Oct 28; 29(43):13578-88. PMID: 19864570; PMCID: PMC2812014.
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PubMed
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PubMed Central
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L,
Spencer B
, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13010-5. PMID: 19651612; PMCID: PMC2722313.
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PubMed Central
Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH,
Spencer B
, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25. PMID: 19176820; PMCID: PMC2768399.
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PubMed Central
Marongiu R,
Spencer B
, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem. 2009 Mar; 108(6):1561-74. PMID: 19166511; PMCID: PMC3902824.
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PubMed Central
Spencer B
, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109. PMID: 19014502; PMCID: PMC2596170.
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PubMed Central
Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H,
Spencer B
, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. PMID: 18769546; PMCID: PMC2519786.
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PubMed Central
Bar-On P, Crews L, Koob AO, Mizuno H, Adame A,
Spencer B
, Masliah E. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J Neurochem. 2008 Jun; 105(5):1656-67. PMID: 18248604; PMCID: PMC2822545.
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PubMed Central
Spencer B
, Rockenstein E, Crews L, Marr R, Masliah E. Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 2007 Dec; 7(12):1853-67. PMID: 18034651.
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PubMed
Spencer B
, Verma IM. Targeted delivery of proteins across the blood-brain barrier. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7594-9. PMID: 17463083; PMCID: PMC1857226.
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PubMed Central
Spencer B
, Crews L, Masliah E. Climbing the scaffolds of Parkinson's disease pathogenesis. Neuron. 2007 Feb 15; 53(4):469-70. PMID: 17296545.
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PubMed
Spencer B
, Blanariu M. Shape and composition map of a prepyramid quantum dot. Phys Rev Lett. 2005 Nov 11; 95(20):206101. PMID: 16384074.
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PubMed
Spencer B
. Asymptotic solutions for the equilibrium crystal shape with small corner energy regularization. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jan; 69(1 Pt 1):011603. PMID: 14995629.
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View timeline visualization
Year
Publications
2004
1
2005
1
2007
3
2008
3
2009
4
2010
3
2011
3
2012
6
2013
1
2014
2
2015
7
2016
4
2017
3
Brian's Networks
Concepts
Derived automatically from this person's publications.
Lewy Body Disease
Neprilysin
alpha-Synuclein
Parkinson Disease
Kallikreins
See all (195) concept(s)
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Co-Authors
People in Profiles who have published with this person.
Patrick, Christina
Masliah, Eliezer
Crews, Leslie Crews
Desplats, Paula
Verma, Inder
See all (17) people
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Similar People
People who share similar concepts with this person.
Galasko, Douglas
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Desplats, Paula
Verma, Inder
See all (60) people
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Same Department
Faget, Lauren
Lessig, Stephanie
Litvan, Irene
Nahab, Fatta
Steinkellner, Thomas
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Gilmer, Todd
Mak, Robert
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Thunemann, Martin
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