Brian Spencer

Title(s)Staff Res Assoc , Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy. Neurobiol Dis. 2023 03; 178:106010. Lin S, Leitão ADG, Fang S, Gu Y, Barber S, Gilliard-Telefoni R, Castro A, Sung K, Shen R, Florio JB, Mante ML, Ding J, Spencer B, Masliah E, Rissman RA, Wu C. PMID: 36702318.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Novel Brain-Penetrating Single Chain Antibodies Directed Against 3RTau for the Treatment of Alzheimer's Disease and Related Dementias. Methods Mol Biol. 2022; 2383:447-457. Spencer B, Rissman RA, Overk C, Masliah E. PMID: 34766306.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression. PLoS One. 2021; 16(9):e0251611. Grundman J, Spencer B, Sarsoza F, Rissman RA. PMID: 34587152; PMCID: PMC8480850.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4). Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. PMID: 33651103; PMCID: PMC7931646.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    5. Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease. Neurobiol Dis. 2019 07; 127:163-177. Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, El-Agnaf OMA, Kim C, Masliah E, Rissman RA. PMID: 30849508; PMCID: PMC6588505.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    6. Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem. 2018 12; 147(6):784-802. Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. PMID: 30152135; PMCID: PMC6310632.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    7. Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders. Acta Neuropathol. 2018 07; 136(1):69-87. Spencer B, Brüschweiler S, Sealey-Cardona M, Rockenstein E, Adame A, Florio J, Mante M, Trinh I, Rissman RA, Konrat R, Masliah E. PMID: 29934874; PMCID: PMC6112111.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    8. Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples. Sci Rep. 2018 03 06; 8(1):4070. Spencer B, Rank L, Metcalf J, Desplats P. PMID: 29511314; PMCID: PMC5840297.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. A Fokker-Planck reaction model for the epitaxial growth and shape transition of quantum dots. Proc Math Phys Eng Sci. 2017 Oct; 473(2206):20170308. Wei C, Spencer BJ. PMID: 29118661; PMCID: PMC5666231.
      View in: PubMed   Mentions:
    10. MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy. Front Mol Neurosci. 2017; 10:329. Valera E, Spencer B, Mott J, Trejo M, Adame A, Mante M, Rockenstein E, Troncoso JC, Beach TG, Masliah E, Desplats P. PMID: 29089869; PMCID: PMC5650998.
      View in: PubMed   Mentions: 26  
    11. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. PMID: 28105557; PMCID: PMC5729903.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 01 13; 5(1):7. Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E. PMID: 28086964; PMCID: PMC5237270.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    13. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 01 05; 5(1):2. Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. PMID: 28057080; PMCID: PMC5217191.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    14. A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481; PMCID: PMC5840882.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    15. α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease. Ann Clin Transl Neurol. 2016 08; 3(8):588-606. Spencer B, Williams S, Rockenstein E, Valera E, Xin W, Mante M, Florio J, Adame A, Masliah E, Sierks MR. PMID: 27606342; PMCID: PMC4999592.
      View in: PubMed   Mentions: 25     Fields:    
    16. Asymmetric shape transitions of epitaxial quantum dots. Proc Math Phys Eng Sci. 2016 Jun; 472(2190):20160262. Wei C, Spencer BJ. PMID: 27436989; PMCID: PMC4950213.
      View in: PubMed   Mentions: 1  
    17. Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease. Hum Mol Genet. 2016 07 01; 25(13):2645-2660. Rockenstein E, Clarke J, Viel C, Panarello N, Treleaven CM, Kim C, Spencer B, Adame A, Park H, Dodge JC, Cheng SH, Shihabuddin LS, Masliah E, Sardi SP. PMID: 27126635; PMCID: PMC5181635.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    18. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236. Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. PMID: 26683203; PMCID: PMC4683943.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    19. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. PMID: 26611103; PMCID: PMC4713337.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    20. Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Rep. 2015 Oct 27; 13(4):771-782. Kim C, Rockenstein E, Spencer B, Kim HK, Adame A, Trejo M, Stafa K, Lee HJ, Lee SJ, Masliah E. PMID: 26489461; PMCID: PMC4752835.
      View in: PubMed   Mentions: 64     Fields:    Translation:Animals
    21. A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener. 2015 Sep 23; 10:48. Spencer B, Valera E, Rockenstein E, Trejo-Morales M, Adame A, Masliah E. PMID: 26394760; PMCID: PMC4580347.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    22. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015; 10(3):e0121570. Rockenstein E, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Bisquert A, Trejo-Morales M, Spencer B, Masliah E. PMID: 25803611; PMCID: PMC4372415.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    23. Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023; PMCID: PMC4944825.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    24. Applications of ApoB LDLR-Binding Domain Approach for the Development of CNS-Penetrating Peptides for Alzheimer's Disease. Methods Mol Biol. 2015; 1324:331-7. Masliah E, Spencer B. PMID: 26202279; PMCID: PMC4928629.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. Cell Metab. 2014 Oct 07; 20(4):626-38. Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, Duarte S, Esau CC, Spencer B, Ashe TD, Fischer KM, MacKenna DA, Sopher BL, Masliah E, Gaasterland T, Chau BN, Pereira de Almeida L, Morrison BE, La Spada AR. PMID: 25295787; PMCID: PMC4245205.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    26. Immunotherapy for Alzheimer's disease: past, present and future. Front Aging Neurosci. 2014; 6:114. Spencer B, Masliah E. PMID: 24959143; PMCID: PMC4051211.
      View in: PubMed   Mentions: 35  
    27. Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol. 2013 Feb; 19(1):89-101. Fields J, Dumaop W, Rockenstein E, Mante M, Spencer B, Grant I, Ellis R, Letendre S, Patrick C, Adame A, Masliah E. PMID: 23341224; PMCID: PMC3567331.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    28. α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. J Biol Chem. 2012 Sep 14; 287(38):31691-702. Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. PMID: 22833673; PMCID: PMC3442504.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    29. In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. J Neurosci. 2012 Jul 18; 32(29):9992-8. Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. PMID: 22815513; PMCID: PMC3491088.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    30. Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. Mol Ther. 2013 Jan; 21(1):31-41. Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, Adame A, Masliah E. PMID: 22508489; PMCID: PMC3538325.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    31. Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. PLoS One. 2012; 7(4):e34713. Cartier AE, Ubhi K, Spencer B, Vazquez-Roque RA, Kosberg KA, Fourgeaud L, Kanayson P, Patrick C, Rockenstein E, Patrick GN, Masliah E. PMID: 22514658; PMCID: PMC3326048.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    32. Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. PMID: 22251432; PMCID: PMC3925782.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    33. Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy. Exp Neurol. 2012 Apr; 234(2):405-16. Ubhi K, Inglis C, Mante M, Patrick C, Adame A, Spencer B, Rockenstein E, May V, Winkler J, Masliah E. PMID: 22281106; PMCID: PMC3897235.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    34. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One. 2011 Apr 29; 6(4):e19338. Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D. PMID: 21559417; PMCID: PMC3084838.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    35. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem. 2011 Mar 18; 286(11):9031-7. Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E. PMID: 21296890; PMCID: PMC3059002.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    36. Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease. PLoS One. 2011 Jan 31; 6(1):e16575. Spencer B, Marr RA, Gindi R, Potkar R, Michael S, Adame A, Rockenstein E, Verma IM, Masliah E. PMID: 21304989; PMCID: PMC3031588.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    37. Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. PLoS One. 2010 Nov 16; 5(11):e14020. Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, Ellisman MH, Masliah E. PMID: 21103359; PMCID: PMC2982819.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    38. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One. 2010 Feb 19; 5(2):e9313. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. PMID: 20174468; PMCID: PMC2824828.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimalsCells
    39. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci. 2009 Oct 28; 29(43):13578-88. Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E. PMID: 19864570; PMCID: PMC2812014.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansAnimalsCells
    40. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13010-5. Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. PMID: 19651612; PMCID: PMC2722313.
      View in: PubMed   Mentions: 747     Fields:    Translation:HumansAnimalsCells
    41. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25. Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. PMID: 19176820; PMCID: PMC2768399.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    42. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem. 2009 Mar; 108(6):1561-74. Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. PMID: 19166511; PMCID: PMC3902824.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    43. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109. Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. PMID: 19014502; PMCID: PMC2596170.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    44. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One. 2008 Sep 04; 3(9):e3135. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. PMID: 18769546; PMCID: PMC2519786.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    45. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. J Neurochem. 2008 Jun; 105(5):1656-67. Bar-On P, Crews L, Koob AO, Mizuno H, Adame A, Spencer B, Masliah E. PMID: 18248604; PMCID: PMC2822545.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    46. Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 2007 Dec; 7(12):1853-67. Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. PMID: 18034651.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    47. Targeted delivery of proteins across the blood-brain barrier. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7594-9. Spencer BJ, Verma IM. PMID: 17463083; PMCID: PMC1857226.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    48. Climbing the scaffolds of Parkinson's disease pathogenesis. Neuron. 2007 Feb 15; 53(4):469-70. Spencer B, Crews L, Masliah E. PMID: 17296545.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    49. Asymptotic solutions for the equilibrium crystal shape with small corner energy regularization. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jan; 69(1 Pt 1):011603. Spencer BJ. PMID: 14995629.
      View in: PubMed   Mentions: 3     Fields:    
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