Jeremy Elman

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-5840-1769 Additional info
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    Biography:
    I am an Assistant Adjunct Professor in the Department of Psychiatry at UC San Diego. I am trained in cognitive neuroscience and have extensive experience employing cognitive testing, neuroimaging, biomarkers, and genetic measures to study Alzheimer’s disease (AD) and aging. I received my doctorate from the University of California, Berkeley under Arthur Shimamura, where I focused on the role of the parietal cortex in memory processes using functional MRI. Following graduate school, I completed a post-doctoral position at the Lawrence Berkeley National Laboratory under William Jagust studying the effects of beta-amyloid on brain and cognition using MRI and amyloid-PET imaging. During this time, my work focused on compensatory brain mechanisms that allow individuals to maintain normal cognitive performance despite the presence of disease pathology. I then completed a post-doctoral position at UC San Diego under William Kremen investigating the genetic and environmental influences on imaging and cognitive measures with the goal of improving early identification of Alzheimer's disease.

    Research Interests:
    My research program seeks to improve early identification by investigating the biological and genetic factors that contribute to heterogeneity in the development and progression of AD. I received a KL2 Career Development Award from the Altman Clinical and Translational Research Institute to pursue this work. I also investigate the role of the locus coeruleus in AD and have explored several measures of its structural and functional integrity for potential use as early screening tools. This work led to a pilot grant from the Shiley-Marcos Alzheimer’s Disease Research Center and I continue to pursue this line of work through several projects with colleagues at UC San Diego. I am a member of the Center for Behavior Genetics of Aging and heavily involved in the Vietnam Era Twin Study of Aging (VETSA). VETSA is a large-scale longitudinal study of adult male twins that collects extensive data (neuropsychological, imaging, genetic, health, and psychosocial) that can be used to study genetic and environmental influences on both healthy aging and disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneity
    NIH K01AG063805Feb 1, 2021 - Jan 31, 2025
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Long-term Associations of Cigarette Smoking in Early Midlife with Predicted Brain Aging from Midlife to Late Life. Addiction. 2021 Oct 04. Whitsel N, Reynolds CA, Buchholz EJ, Pahlen S, Pearce RC, Hatton SN, Elman JA, Gillespie NA, Gustavson DE, Puckett OK, Dale AM, Eyler LT, Fennema-Notestine C, Hagler DJ, Hauger RL, McEvoy LK, McKenzie R, Neale MC, Panizzon MS, Sanderson-Cimino M, Toomey R, Tu XM, Williams MKE, Bell T, Xian H, Lyons MJ, Kremen WS, Franz CE. PMID: 34605095.
      View in: PubMed   Mentions:    Fields:    
    2. Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age. Neurobiol Aging. 2021 Aug 19; 108:80-89. Franz CE, Hatton SN, Elman JA, Warren T, Gillespie NA, Whitsel NA, Puckett OK, Dale AM, Eyler LT, Fennema-Notestine C, Hagler DJ, Hauger RL, McKenzie R, Neale MC, Panizzon MS, Pearce RC, Reynolds CA, Sanderson-Cimino M, Toomey R, Tu XM, Williams M, Xian H, Lyons MJ, Kremen WS. PMID: 34547718.
      View in: PubMed   Mentions:    Fields:    
    3. 12-year prediction of mild cognitive impairment aided by Alzheimer's brain signatures at mean age 56. Brain Commun. 2021; 3(3):fcab167. Williams ME, Elman JA, McEvoy LK, Andreassen OA, Dale AM, Eglit GML, Eyler LT, Fennema-Notestine C, Franz CE, Gillespie NA, Hagler DJ, Hatton SN, Hauger RL, Jak AJ, Logue MW, Lyons MJ, McKenzie RE, Neale MC, Panizzon MS, Puckett OK, Reynolds CA, Sanderson-Cimino M, Toomey R, Tu XM, Whitsel N, Xian H, Kremen WS. PMID: 34396116.
      View in: PubMed   Mentions:
    4. The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan. Elife. 2021 06 28; 10. Fjell AM, Grydeland H, Wang Y, Amlien IK, Bartres-Faz D, Brandmaier AM, Düzel S, Elman J, Franz CE, Håberg AK, Kietzmann TC, Kievit RA, Kremen WS, Krogsrud SK, Kühn S, Lindenberger U, Macía D, Mowinckel AM, Nyberg L, Panizzon MS, Solé-Padullés C, Sørensen Ø, Westerhausen R, Walhovd KB. PMID: 34180395.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife. Neuropsychology. 2021 Mar; 35(3):252-264. Sanderson-Cimino M, Panizzon MS, Elman JA, Tu X, Gustavson DE, Puckett O, Cross K, Notestine R, Hatton SN, Eyler LT, McEvoy LK, Hagler DJ, Neale MC, Gillespie NA, Lyons MJ, Franz CE, Fennema-Notestine C, Kremen WS. PMID: 33970659.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction. Alzheimers Dement. 2021 06; 17(6):1017-1025. Elman JA, Puckett OK, Beck A, Fennema-Notestine C, Cross LK, Dale AM, Eglit GML, Eyler LT, Gillespie NA, Granholm EL, Gustavson DE, Hagler DJ, Hatton SN, Hauger R, Jak AJ, Logue MW, McEvoy LK, McKenzie RE, Neale MC, Panizzon MS, Reynolds CA, Sanderson-Cimino M, Toomey R, Tu XM, Whitsel N, Williams ME, Xian H, Lyons MJ, Franz CE, Kremen WS. PMID: 33580733.
      View in: PubMed   Mentions: 2     Fields:    
    7. Associations between depression and cardiometabolic health: A 27-year longitudinal study. Psychol Med. 2021 Jan 12; 1-11. Ditmars HL, Logue MW, Toomey R, McKenzie RE, Franz CE, Panizzon MS, Reynolds CA, Cuthbert KN, Vandiver R, Gustavson DE, Eglit GML, Elman JA, Sanderson-Cimino M, Williams ME, Andreassen OA, Dale AM, Eyler LT, Fennema-Notestine C, Gillespie NA, Hauger RL, Jak AJ, Neale MC, Tu XM, Whitsel N, Xian H, Kremen WS, Lyons MJ. PMID: 33431106.
      View in: PubMed   Mentions:    Fields:    
    8. How Well Does Subjective Cognitive Decline Correspond to Objectively Measured Cognitive Decline? Assessment of 10-12 Year Change. J Alzheimers Dis. 2021; 83(1):291-304. Gustavson DE, Jak AJ, Elman JA, Panizzon MS, Franz CE, Gifford KA, Reynolds CA, Toomey R, Lyons MJ, Kremen WS. PMID: 34308902.
      View in: PubMed   Mentions:    Fields:    
    9. Cognitive Practice Effects Delay Diagnosis; Implications for Clinical Trials. medRxiv. 2020 Nov 05. Sanderson-Cimino M, Elman JA, Tu XM, Gross AL, Panizzon MS, Gustavson DE, Bondi MW, Edmonds EC, Eglit GML, Eppig JS, Franz CE, Jak AJ, Lyons MJ, Thomas KR, Williams ME, Kremen WS. PMID: 33173908.
      View in: PubMed   Mentions:
    10. Metabolic Profiling of Cognitive Aging in Midlife. Front Aging Neurosci. 2020; 12:555850. Huo Z, Rana BK, Elman JA, Dong R, Engelman CD, Johnson SC, Lyons MJ, Franz CE, Kremen WS, Zhao J. PMID: 33250761.
      View in: PubMed   Mentions:
    11. Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men. J Int Neuropsychol Soc. 2021 01; 27(1):56-68. Slayday RE, Gustavson DE, Elman JA, Beck A, McEvoy LK, Tu XM, Fang B, Hauger RL, Lyons MJ, McKenzie RE, Sanderson-Cimino ME, Xian H, Kremen WS, Franz CE. PMID: 32662384.
      View in: PubMed   Mentions: 1     Fields:    
    12. Association of baseline semantic fluency and progression to mild cognitive impairment in middle-aged men. Neurology. 2020 08 25; 95(8):e973-e983. Gustavson DE, Elman JA, Panizzon MS, Franz CE, Zuber J, Sanderson-Cimino M, Reynolds CA, Jacobson KC, Xian H, Jak AJ, Toomey R, Lyons MJ, Kremen WS. PMID: 32606222.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Degree of cognitive impairment does not signify early versus late mild cognitive impairment: confirmation based on Alzheimer's disease polygenic risk. Neurobiol Aging. 2020 10; 94:149-153. Elman JA, Vuoksimaa E, Franz CE, Kremen WS, Alzheimer’s Disease Neuroimaging Initiative . PMID: 32623261.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Genetic Underpinnings of Increased BMI and Its Association With Late Midlife Cognitive Abilities. Gerontol Geriatr Med. 2020 Jan-Dec; 6:2333721420925267. Xian H, Boutwell B, Reynolds CA, Lew D, Logue M, Gustavson DE, Kavish N, Panizzon MS, Tu X, Toomey R, Puckett OK, Elman JA, Jacobson KC, Lyons MJ, Kremen WS, Franz CE. PMID: 32537479.
      View in: PubMed   Mentions:
    15. Extensive memory testing improves prediction of progression to MCI in late middle age. Alzheimers Dement (Amst). 2020; 12(1):e12004. Gustavson DE, Elman JA, Sanderson-Cimino M, Franz CE, Panizzon MS, Jak AJ, Reynolds CA, Neale MC, Lyons MJ, Kremen WS. PMID: 32284960.
      View in: PubMed   Mentions:
    16. Amyloid-β Positivity Predicts Cognitive Decline but Cognition Predicts Progression to Amyloid-β Positivity. Biol Psychiatry. 2020 05 01; 87(9):819-828. Elman JA, Panizzon MS, Gustavson DE, Franz CE, Sanderson-Cimino ME, Lyons MJ, Kremen WS, Alzheimer’s Disease Neuroimaging Initiative . PMID: 32067693.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk. Neurobiol Aging. 2019 11; 83:114-121. Kremen WS, Panizzon MS, Elman JA, Granholm EL, Andreassen OA, Dale AM, Gillespie NA, Gustavson DE, Logue MW, Lyons MJ, Neale MC, Reynolds CA, Whitsel N, Franz CE. PMID: 31585363.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    18. Genetic and environmental architecture of processing speed across midlife. Neuropsychology. 2019 Sep; 33(6):862-871. Sanderson-Cimino M, Panizzon MS, Elman JA, Gustavson DE, Franz CE, Reynolds CA, Toomey R, Lyons MJ, Kremen WS. PMID: 31192653.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment. Neurobiol Aging. 2019 12; 84:237.e5-237.e12. Elman JA, Panizzon MS, Logue MW, Gillespie NA, Neale MC, Reynolds CA, Gustavson DE, Rana BK, Andreassen OA, Dale AM, Franz CE, Lyons MJ, Kremen WS. PMID: 31272697.
      View in: PubMed   Mentions: 1     Fields:    
    20. Mechanisms underlying resilience in ageing. Nat Rev Neurosci. 2019 04; 20(4):246. Stern Y, Chételat G, Habeck C, Arenaza-Urquijo EM, Vemuri P, Estanga A, Bartrés-Faz D, Cantillon M, Clouston SAP, Elman JA, Gold BT, Jones R, Kempermann G, Lim YY, van Loenhoud A, Martínez-Lage P, Morbelli S, Okonkwo O, Ossenkoppele R, Pettigrew C, Rosen AC, Scarmeas N, Soldan A, Udeh-Momoh C, Valenzuela M, Vuoksimaa E. PMID: 30814677.
      View in: PubMed   Mentions: 6     Fields:    
    21. Influence of young adult cognitive ability and additional education on later-life cognition. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2021-2026. Kremen WS, Beck A, Elman JA, Gustavson DE, Reynolds CA, Tu XM, Sanderson-Cimino ME, Panizzon MS, Vuoksimaa E, Toomey R, Fennema-Notestine C, Hagler DJ, Fang B, Dale AM, Lyons MJ, Franz CE. PMID: 30670647.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    22. Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2019; 70(1):107-120. Eyler LT, Elman JA, Hatton SN, Gough S, Mischel AK, Hagler DJ, Franz CE, Docherty A, Fennema-Notestine C, Gillespie N, Gustavson D, Lyons MJ, Neale MC, Panizzon MS, Dale AM, Kremen WS. PMID: 31177210.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. Genetic architecture of hippocampal subfields on standard resolution MRI: How the parts relate to the whole. Hum Brain Mapp. 2019 04 01; 40(5):1528-1540. Elman JA, Panizzon MS, Gillespie NA, Hagler DJ, Fennema-Notestine C, Eyler LT, McEvoy LK, Neale MC, Lyons MJ, Franz CE, Dale AM, Kremen WS. PMID: 30430703.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Predominantly global genetic influences on individual white matter tract microstructure. Neuroimage. 2019 01 01; 184:871-880. Gustavson DE, Hatton SN, Elman JA, Panizzon MS, Franz CE, Hagler DJ, Fennema-Notestine C, Eyler LT, McEvoy LK, Neale MC, Gillespie N, Dale AM, Lyons MJ, Kremen WS. PMID: 30296555.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Genetic and Environmental Influences on Verbal Fluency in Middle Age: A Longitudinal Twin Study. Behav Genet. 2018 09; 48(5):361-373. Gustavson DE, Panizzon MS, Elman JA, Franz CE, Beck A, Reynolds CA, Jacobson KC, Xian H, Toomey R, Lyons MJ, Kremen WS. PMID: 29922985.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Underdiagnosis of mild cognitive impairment: A consequence of ignoring practice effects. Alzheimers Dement (Amst). 2018; 10:372-381. Elman JA, Jak AJ, Panizzon MS, Tu XM, Chen T, Reynolds CA, Gustavson DE, Franz CE, Hatton SN, Jacobson KC, Toomey R, McKenzie R, Xian H, Lyons MJ, Kremen WS. PMID: 30003138.
      View in: PubMed   Mentions:
    27. Negative fateful life events in midlife and advanced predicted brain aging. Neurobiol Aging. 2018 07; 67:1-9. Hatton SN, Franz CE, Elman JA, Panizzon MS, Hagler DJ, Fennema-Notestine C, Eyler LT, McEvoy LK, Lyons MJ, Dale AM, Kremen WS. PMID: 29609076.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. Stability of genetic and environmental influences on executive functions in midlife. Psychol Aging. 2018 03; 33(2):219-231. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Gustavson DE, Panizzon MS, Elman JA, Franz CE, Reynolds CA, Jacobson KC, Friedman NP, Xian H, Toomey R, Lyons MJ, Kremen WS. PMID: 29658745; PMCID: PMC5905725.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    29. Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s. Mol Psychiatry. 2019 03; 24(3):421-430. Logue MW, Panizzon MS, Elman JA, Gillespie NA, Hatton SN, Gustavson DE, Andreassen OA, Dale AM, Franz CE, Lyons MJ, Neale MC, Reynolds CA, Tu X, Kremen WS. PMID: 29487403.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    30. Alcohol intake and brain white matter in middle aged men: Microscopic and macroscopic differences. Neuroimage Clin. 2018; 18:390-398. McEvoy LK, Fennema-Notestine C, Elman JA, Eyler LT, Franz CE, Hagler DJ, Hatton SN, Lyons MJ, Panizzon MS, Dale AM, Kremen WS. PMID: 29487796.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    31. Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction. Cortex. 2017 12; 97:60-69. Elman JA, Panizzon MS, Hagler DJ, Eyler LT, Granholm EL, Fennema-Notestine C, Lyons MJ, McEvoy LK, Franz CE, Dale AM, Kremen WS. PMID: 29096196.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    32. Pupillary Responses as a Biomarker of Early Risk for Alzheimer's Disease. J Alzheimers Dis. 2017; 56(4):1419-1428. Granholm EL, Panizzon MS, Elman JA, Jak AJ, Hauger RL, Bondi MW, Lyons MJ, Franz CE, Kremen WS. PMID: 28157098.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    33. Genetic and environmental influences on cortical mean diffusivity. Neuroimage. 2017 Feb 01; 146:90-99. Elman JA, Panizzon MS, Hagler DJ, Fennema-Notestine C, Eyler LT, Gillespie NA, Neale MC, Lyons MJ, Franz CE, McEvoy LK, Dale AM, Kremen WS. PMID: 27864081.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    34. Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability. Cereb Cortex. 2016 Feb; 26(2):695-707. Elman JA, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O'Neil JP, Jagust WJ. PMID: 25405944.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    35. Neural compensation in older people with brain amyloid-β deposition. Nat Neurosci. 2014 Oct; 17(10):1316-8. Elman JA, Oh H, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O'Neil JP, Jagust WJ. PMID: 25217827.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    36. Dynamic changes in parietal activation during encoding: implications for human learning and memory. Neuroimage. 2013 Nov 15; 82:44-52. Elman JA, Rosner ZA, Cohn-Sheehy BI, Cerreta AG, Shimamura AP. PMID: 23732887.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    37. Dissociable parietal regions facilitate successful retrieval of recently learned and personally familiar information. Neuropsychologia. 2013 Mar; 51(4):573-83. Elman JA, Cohn-Sheehy BI, Shimamura AP. PMID: 23287568.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    38. The generation effect: activating broad neural circuits during memory encoding. Cortex. 2013 Jul-Aug; 49(7):1901-9. Rosner ZA, Elman JA, Shimamura AP. PMID: 23079490.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    39. Neural correlates of metacognitive monitoring during episodic and semantic retrieval. Cogn Affect Behav Neurosci. 2012 Sep; 12(3):599-609. Elman JA, Klostermann EC, Marian DE, Verstaen A, Shimamura AP. PMID: 22562436.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    40. Task relevance modulates successful retrieval effects during explicit and implicit memory tests. Neuroimage. 2011 May 01; 56(1):345-53. Elman JA, Shimamura AP. PMID: 21316476.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    41. Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria. Neurobiol Aging. 2010 Mar; 31(3):368-77. Chao LL, Mueller SG, Buckley ST, Peek K, Raptentsetseng S, Elman J, Yaffe K, Miller BL, Kramer JH, Madison C, Mungas D, Schuff N, Weiner MW. PMID: 18550226.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    42. Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T. Neuroimage. 2008 Aug 01; 42(1):42-8. Mueller SG, Schuff N, Raptentsetsang S, Elman J, Weiner MW. PMID: 18534867.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
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