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Jeremy Elman

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolHealth Sciences
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    Biography:
    I am an Assistant Adjunct Professor in the Department of Psychiatry at UC San Diego. I am trained in cognitive neuroscience and have extensive experience employing cognitive testing, neuroimaging, biomarkers, and genetic measures to study Alzheimer’s disease (AD) and aging. I received my doctorate from the University of California, Berkeley under Arthur Shimamura, where I focused on the role of the parietal cortex in memory processes using functional MRI. Following graduate school, I completed a post-doctoral position at the Lawrence Berkeley National Laboratory under William Jagust studying the effects of beta-amyloid on brain and cognition using MRI and amyloid-PET imaging. During this time, my work focused on compensatory brain mechanisms that allow individuals to maintain normal cognitive performance despite the presence of disease pathology. I then completed a post-doctoral position at UC San Diego under William Kremen investigating the genetic and environmental influences on imaging and cognitive measures with the goal of improving early identification of Alzheimer's disease.

    Research Interests:
    My research program seeks to improve early identification by investigating the biological and genetic factors that contribute to heterogeneity in the development and progression of AD. I received a KL2 Career Development Award from the Altman Clinical Trials Research Institute to pursue this work. I also investigate the role of the locus coeruleus in AD and have explored several measures of its structural and functional integrity for potential use as early screening tools. This work led to a pilot grant from the Shiley-Marcos Alzheimer’s Disease Research Center and I continue to pursue this line of work on through several projects with colleagues at UC San Diego. I am also a member of the Center for Behavior Genetics of Aging and heavily involved in the Vietnam Era Twin Study of Aging (VETSA). VETSA is a large-scale longitudinal study of adult male twins that collects extensive data (neuropsychological, imaging, genetic, health, and psychosocial) that can be used to study genetic and environmental influences on both healthy aging and disease.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sanderson-Cimino M, Panizzon MS, Elman JA, Gustavson DE, Franz CE, Reynolds CA, Toomey R, Lyons MJ, Kremen WS. Genetic and environmental architecture of processing speed across midlife. Neuropsychology. 2019 Jun 13. PMID: 31192653.
      View in: PubMed
    2. Elman JA, Panizzon MS, Logue MW, Gillespie NA, Neale MC, Reynolds CA, Gustavson DE, Rana BK, Andreassen OA, Dale AM, Franz CE, Lyons MJ, Kremen WS. Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment. Neurobiol Aging. 2019 Jun 08. PMID: 31272697.
      View in: PubMed
    3. Eyler LT, Elman JA, Hatton SN, Gough S, Mischel AK, Hagler DJ, Franz CE, Docherty A, Fennema-Notestine C, Gillespie N, Gustavson D, Lyons MJ, Neale MC, Panizzon MS, Dale AM, Kremen WS. Resting State Abnormalities of the Default Mode Network in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2019 Jun 04. PMID: 31177210.
      View in: PubMed
    4. Stern Y, Chételat G, Habeck C, Arenaza-Urquijo EM, Vemuri P, Estanga A, Bartrés-Faz D, Cantillon M, Clouston SAP, Elman JA, Gold BT, Jones R, Kempermann G, Lim YY, van Loenhoud A, Martínez-Lage P, Morbelli S, Okonkwo O, Ossenkoppele R, Pettigrew C, Rosen AC, Scarmeas N, Soldan A, Udeh-Momoh C, Valenzuela M, Vuoksimaa E. Mechanisms underlying resilience in ageing. Nat Rev Neurosci. 2019 Apr; 20(4):246. PMID: 30814677.
      View in: PubMed
    5. Kremen WS, Beck A, Elman JA, Gustavson DE, Reynolds CA, Tu XM, Sanderson-Cimino ME, Panizzon MS, Vuoksimaa E, Toomey R, Fennema-Notestine C, Hagler DJ, Fang B, Dale AM, Lyons MJ, Franz CE. Influence of young adult cognitive ability and additional education on later-life cognition. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2021-2026. PMID: 30670647.
      View in: PubMed
    6. Elman JA, Panizzon MS, Gillespie NA, Hagler DJ, Fennema-Notestine C, Eyler LT, McEvoy LK, Neale MC, Lyons MJ, Franz CE, Dale AM, Kremen WS. Genetic architecture of hippocampal subfields on standard resolution MRI: How the parts relate to the whole. Hum Brain Mapp. 2019 Apr 01; 40(5):1528-1540. PMID: 30430703.
      View in: PubMed
    7. Gustavson DE, Hatton SN, Elman JA, Panizzon MS, Franz CE, Hagler DJ, Fennema-Notestine C, Eyler LT, McEvoy LK, Neale MC, Gillespie N, Dale AM, Lyons MJ, Kremen WS. Predominantly global genetic influences on individual white matter tract microstructure. Neuroimage. 2019 01 01; 184:871-880. PMID: 30296555.
      View in: PubMed
    8. Gustavson DE, Panizzon MS, Elman JA, Franz CE, Beck A, Reynolds CA, Jacobson KC, Xian H, Toomey R, Lyons MJ, Kremen WS. Genetic and Environmental Influences on Verbal Fluency in Middle Age: A Longitudinal Twin Study. Behav Genet. 2018 Sep; 48(5):361-373. PMID: 29922985.
      View in: PubMed
    9. Elman JA, Jak AJ, Panizzon MS, Tu XM, Chen T, Reynolds CA, Gustavson DE, Franz CE, Hatton SN, Jacobson KC, Toomey R, McKenzie R, Xian H, Lyons MJ, Kremen WS. Underdiagnosis of mild cognitive impairment: A consequence of ignoring practice effects. Alzheimers Dement (Amst). 2018; 10:372-381. PMID: 30003138.
      View in: PubMed
    10. Hatton SN, Franz CE, Elman JA, Panizzon MS, Hagler DJ, Fennema-Notestine C, Eyler LT, McEvoy LK, Lyons MJ, Dale AM, Kremen WS. Negative fateful life events in midlife and advanced predicted brain aging. Neurobiol Aging. 2018 07; 67:1-9. PMID: 29609076.
      View in: PubMed
    11. Gustavson DE, Panizzon MS, Elman JA, Franz CE, Reynolds CA, Jacobson KC, Friedman NP, Xian H, Toomey R, Lyons MJ, Kremen WS. Stability of genetic and environmental influences on executive functions in midlife. Psychol Aging. 2018 03; 33(2):219-231. PMID: 29658745.
      View in: PubMed
    12. Logue MW, Panizzon MS, Elman JA, Gillespie NA, Hatton SN, Gustavson DE, Andreassen OA, Dale AM, Franz CE, Lyons MJ, Neale MC, Reynolds CA, Tu X, Kremen WS. Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s. Mol Psychiatry. 2019 Mar; 24(3):421-430. PMID: 29487403.
      View in: PubMed
    13. McEvoy LK, Fennema-Notestine C, Elman JA, Eyler LT, Franz CE, Hagler DJ, Hatton SN, Lyons MJ, Panizzon MS, Dale AM, Kremen WS. Alcohol intake and brain white matter in middle aged men: Microscopic and macroscopic differences. Neuroimage Clin. 2018; 18:390-398. PMID: 29487796.
      View in: PubMed
    14. Elman JA, Panizzon MS, Hagler DJ, Eyler LT, Granholm EL, Fennema-Notestine C, Lyons MJ, McEvoy LK, Franz CE, Dale AM, Kremen WS. Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction. Cortex. 2017 12; 97:60-69. PMID: 29096196.
      View in: PubMed
    15. Granholm EL, Panizzon MS, Elman JA, Jak AJ, Hauger RL, Bondi MW, Lyons MJ, Franz CE, Kremen WS. Pupillary Responses as a Biomarker of Early Risk for Alzheimer's Disease. J Alzheimers Dis. 2017; 56(4):1419-1428. PMID: 28157098.
      View in: PubMed
    16. Elman JA, Panizzon MS, Hagler DJ, Fennema-Notestine C, Eyler LT, Gillespie NA, Neale MC, Lyons MJ, Franz CE, McEvoy LK, Dale AM, Kremen WS. Genetic and environmental influences on cortical mean diffusivity. Neuroimage. 2017 Feb 01; 146:90-99. PMID: 27864081.
      View in: PubMed
    17. Elman JA, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O'Neil JP, Jagust WJ. Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability. Cereb Cortex. 2016 Feb; 26(2):695-707. PMID: 25405944.
      View in: PubMed
    18. Elman JA, Oh H, Madison CM, Baker SL, Vogel JW, Marks SM, Crowley S, O'Neil JP, Jagust WJ. Neural compensation in older people with brain amyloid-ß deposition. Nat Neurosci. 2014 Oct; 17(10):1316-8. PMID: 25217827; PMCID: PMC4177011.
    19. Elman JA, Rosner ZA, Cohn-Sheehy BI, Cerreta AG, Shimamura AP. Dynamic changes in parietal activation during encoding: implications for human learning and memory. Neuroimage. 2013 Nov 15; 82:44-52. PMID: 23732887.
      View in: PubMed
    20. Elman JA, Cohn-Sheehy BI, Shimamura AP. Dissociable parietal regions facilitate successful retrieval of recently learned and personally familiar information. Neuropsychologia. 2013 Mar; 51(4):573-83. PMID: 23287568.
      View in: PubMed
    21. Rosner ZA, Elman JA, Shimamura AP. The generation effect: activating broad neural circuits during memory encoding. Cortex. 2013 Jul-Aug; 49(7):1901-9. PMID: 23079490; PMCID: PMC3556209.
    22. Elman JA, Klostermann EC, Marian DE, Verstaen A, Shimamura AP. Neural correlates of metacognitive monitoring during episodic and semantic retrieval. Cogn Affect Behav Neurosci. 2012 Sep; 12(3):599-609. PMID: 22562436.
      View in: PubMed
    23. Elman JA, Shimamura AP. Task relevance modulates successful retrieval effects during explicit and implicit memory tests. Neuroimage. 2011 May 01; 56(1):345-53. PMID: 21316476.
      View in: PubMed
    24. Chao LL, Mueller SG, Buckley ST, Peek K, Raptentsetseng S, Elman J, Yaffe K, Miller BL, Kramer JH, Madison C, Mungas D, Schuff N, Weiner MW. Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria. Neurobiol Aging. 2010 Mar; 31(3):368-77. PMID: 18550226; PMCID: PMC2814904.
    25. Mueller SG, Schuff N, Raptentsetsang S, Elman J, Weiner MW. Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T. Neuroimage. 2008 Aug 01; 42(1):42-8. PMID: 18534867; PMCID: PMC2597377.
    26. Bates E, Elman J. Learning rediscovered. Science. 1996 Dec 13; 274(5294):1849-50. PMID: 8984644.
      View in: PubMed