Loading...

Nigel Calcutt

Title(s)Professor, Pathology
SchoolHealth Sciences
Phone858-534-5331
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Muscarinic receptor antagonists as a therapy for diabetic neuropathy
    NIH/NIDDK R21DK102032Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Cholinergic constraint and diabetic neuropathy
    NIH/NINDS R01NS081082Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Non Phamacologic Treatments for Diabetic Neuropathy
    NIH/NINDS R21NS062346Feb 1, 2009 - Jan 31, 2012
    Role: Principal Investigator
    Near Infra Red Energy To Treat Diabetic Neuropathy
    NIH/NINDS R21NS050232Jul 1, 2005 - Jun 30, 2007
    Role: Principal Investigator
    Mechanisms of Spinally-Mediated Hyperalgesia in Diabetes
    NIH/NIDDK R01DK057629Apr 1, 2000 - Jul 31, 2014
    Role: Principal Investigator
    PROSAPOSIN AND PROSAPTIDES IN DIABETIC NEUROPATHY
    NIH/NINDS R01NS038855Sep 30, 1999 - Aug 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yorek M, Malik RA, Calcutt NA, Vinik A, Yagihashi S. Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments. J Diabetes Res. 2018; 2018:5378439. PMID: 30648115.
      View in: PubMed
    2. Aghanoori MR, Smith DR, Shariati-Ievari S, Ajisebutu A, Nguyen A, Desmond F, Jesus CHA, Zhou X, Calcutt NA, Aliani M, Fernyhough P. Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes. Mol Metab. 2018 Nov 28. PMID: 30545741.
      View in: PubMed
    3. Sabbir MG, Calcutt NA, Fernyhough P. Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons. Front Neurosci. 2018; 12:402. PMID: 29997469.
      View in: PubMed
    4. Villalón E, Barry DM, Byers N, Frizzi K, Jones MR, Landayan DS, Dale JM, Downer NL, Calcutt NA, Garcia ML. Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons. Exp Neurol. 2018 08; 306:158-168. PMID: 29772247.
      View in: PubMed
    5. Lee-Kubli C, Marshall AG, Malik RA, Calcutt NA. The H-Reflex as a Biomarker for Spinal Disinhibition in Painful Diabetic Neuropathy. Curr Diab Rep. 2018 Jan 23; 18(1):1. PMID: 29362940.
      View in: PubMed
    6. Daugherty DJ, Marquez A, Calcutt NA, Schubert D. A novel curcumin derivative for the treatment of diabetic neuropathy. Neuropharmacology. 2018 Feb; 129:26-35. PMID: 29122628.
      View in: PubMed
    7. Aghanoori MR, Smith DR, Roy Chowdhury S, Sabbir MG, Calcutt NA, Fernyhough P. Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats. Exp Neurol. 2017 11; 297:148-157. PMID: 28803751.
      View in: PubMed
    8. Jones MR, Villalón E, Northcutt AJ, Calcutt NA, Garcia ML. Differential effects of myostatin deficiency on motor and sensory axons. Muscle Nerve. 2017 Dec; 56(6):E100-E107. PMID: 28073155.
      View in: PubMed
    9. Marshall AG, Lee-Kubli C, Azmi S, Zhang M, Ferdousi M, Mixcoatl-Zecuatl T, Petropoulos IN, Ponirakis G, Fineman MS, Fadavi H, Frizzi K, Tavakoli M, Jeziorska M, Jolivalt CG, Boulton AJM, Efron N, Calcutt NA, Malik RA. Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Diabetes. 2017 05; 66(5):1380-1390. PMID: 28202580.
      View in: PubMed
    10. Gonçalves NP, Vægter CB, Andersen H, Østergaard L, Calcutt NA, Jensen TS. Schwann cell interactions with axons and microvessels in diabetic neuropathy. Nat Rev Neurol. 2017 Mar; 13(3):135-147. PMID: 28134254.
      View in: PubMed
    11. Calcutt NA, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P. Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. J Clin Invest. 2017 Feb 01; 127(2):608-622. PMID: 28094765.
      View in: PubMed
    12. Jolivalt CG, Frizzi KE, Guernsey L, Marquez A, Ochoa J, Rodriguez M, Calcutt NA. Peripheral Neuropathy in Mouse Models of Diabetes. Curr Protoc Mouse Biol. 2016 Sep 01; 6(3):223-55. PMID: 27584552; PMCID: PMC5023323 [Available on 09/01/17].
      View in: PubMed, PubMed Central
    13. Calcutt NA, Fernyhough P. A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:3-8. PMID: 27133141.
      View in: PubMed
    14. Calcutt NA, Fernyhough P. An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:45-52. PMID: 27133144.
      View in: PubMed
    15. Fernyhough P, Calcutt NA. An Introduction to the History and Controversies of the Pathogenesis of Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:115-20. PMID: 27133147.
      View in: PubMed
    16. Fernyhough P, Calcutt NA. New Directions in Diabetic Neuropathy: Evolution or Extinction? Int Rev Neurobiol. 2016; 127:229-34. PMID: 27133152.
      View in: PubMed
    17. Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt NA, Delgado-Lezama R, Marsala M, Granados-Soto V. The a5 subunit containing GABAA receptors contribute to chronic pain. Pain. 2016 Mar; 157(3):613-26. PMID: 26545088; PMCID: PMC4950669 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    18. Rocca CJ, Kreymerman A, Ur SN, Frizzi KE, Naphade S, Lau A, Tran T, Calcutt NA, Goldberg JL, Cherqui S. Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7214-23. PMID: 26540660; PMCID: PMC4640476.
      View in: PubMed, PubMed Central
    19. Jolivalt CG, Rodriguez M, Wahren J, Calcutt NA. Efficacy of a long-acting C-peptide analogue against peripheral neuropathy in streptozotocin-diabetic mice. Diabetes Obes Metab. 2015 Aug; 17(8):781-8. PMID: 25904006.
      View in: PubMed
    20. Hollis ER, Ishiko N, Pessian M, Tolentino K, Lee-Kubli CA, Calcutt NA, Zou Y. Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery. Nat Commun. 2015 Jan 19; 6:6079. PMID: 25597627; PMCID: PMC4831586.
      View in: PubMed, PubMed Central
    21. Hollis ER, Ishiko N, Tolentino K, Doherty E, Rodriguez MJ, Calcutt NA, Zou Y. A novel and robust conditioning lesion induced by ethidium bromide. Exp Neurol. 2015 Mar; 265:30-9. PMID: 25541322; PMCID: PMC4346483.
      View in: PubMed, PubMed Central
    22. Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Feldman EL, Fernyhough P, Jakobsen J, Malik RA, Mizisin AP, Oates PJ, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Veves A, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW. Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab). J Peripher Nerv Syst. 2014 Jun; 19(2):77-87. PMID: 24934510; PMCID: PMC4303044.
      View in: PubMed, PubMed Central
    23. Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, Calcutt NA, Fernyhough P. Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents. Cell Mol Neurobiol. 2014 Jul; 34(5):643-9. PMID: 24682898.
      View in: PubMed
    24. Hedstrom KL, Murtie JC, Albers K, Calcutt NA, Corfas G. Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRa/RET receptor signaling. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2325-30. PMID: 24449858; PMCID: PMC3926041.
      View in: PubMed, PubMed Central
    25. Lee-Kubli CA, Calcutt NA. Painful neuropathy: Mechanisms. Handb Clin Neurol. 2014; 126:533-57. PMID: 25410243.
      View in: PubMed
    26. Lee-Kubli CA, Mixcoatl-Zecuatl T, Jolivalt CG, Calcutt NA. Animal models of diabetes-induced neuropathic pain. Curr Top Behav Neurosci. 2014; 20:147-70. PMID: 24510303.
      View in: PubMed
    27. Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt NA. Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst. 2013 Dec; 18(4):306-15. PMID: 24147903; PMCID: PMC3981941.
      View in: PubMed, PubMed Central
    28. Calcutt NA. Location, location, location?: is the pain of diabetic neuropathy generated by hyperactive sensory neurons? Diabetes. 2013 Nov; 62(11):3658-60. PMID: 24158992; PMCID: PMC3806595.
      View in: PubMed, PubMed Central
    29. Lee-Kubli CA, Calcutt NA. Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain. Pain. 2014 Feb; 155(2):250-60. PMID: 24103402; PMCID: PMC3946970.
      View in: PubMed, PubMed Central
    30. Hadimani MB, Purohit MK, Vanampally C, Van der Ploeg R, Arballo V, Morrow D, Frizzi KE, Calcutt NA, Fernyhough P, Kotra LP. Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy. J Med Chem. 2013 Jun 27; 56(12):5071-8. PMID: 23758573.
      View in: PubMed
    31. Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi KE, Calcutt NA, Fernyhough P. Ciliary neurotrophic factor activates NF-?B to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents. Neuropharmacology. 2013 Feb; 65:65-73. PMID: 23022047; PMCID: PMC3521091.
      View in: PubMed, PubMed Central
    32. Gregory JA, Jolivalt CG, Goor J, Mizisin AP, Calcutt NA. Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats. Acta Neuropathol. 2012 Oct; 124(4):561-73. PMID: 22791295.
      View in: PubMed
    33. Roy Chowdhury SK, Smith DR, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt NA, Fernyhough P. Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes. Brain. 2012 Jun; 135(Pt 6):1751-66. PMID: 22561641; PMCID: PMC3359752.
      View in: PubMed, PubMed Central
    34. Barry DM, Stevenson W, Bober BG, Wiese PJ, Dale JM, Barry GS, Byers NS, Strope JD, Chang R, Schulz DJ, Shah S, Calcutt NA, Gebremichael Y, Garcia ML. Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness. J Neurosci. 2012 May 02; 32(18):6209-19. PMID: 22553027; PMCID: PMC3363292.
      View in: PubMed, PubMed Central
    35. Jolivalt CG, Calcutt NA, Masliah E. Similar pattern of peripheral neuropathy in mouse models of type 1 diabetes and Alzheimer's disease. Neuroscience. 2012 Jan 27; 202:405-12. PMID: 22178988; PMCID: PMC3268846.
      View in: PubMed, PubMed Central
    36. Jolivalt CG, Fineman M, Deacon CF, Carr RD, Calcutt NA. GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. Diabetes Obes Metab. 2011 Nov; 13(11):990-1000. PMID: 21635674; PMCID: PMC3177968.
      View in: PubMed, PubMed Central
    37. Landgraf RR, Garrett TJ, Conaway MC, Calcutt NA, Stacpoole PW, Yost RA. Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging. Rapid Commun Mass Spectrom. 2011 Oct 30; 25(20):3178-84. PMID: 21953974; PMCID: PMC3926214.
      View in: PubMed, PubMed Central
    38. Shen H, Barry DM, Dale JM, Garcia VB, Calcutt NA, Garcia ML. Muscle pathology without severe nerve pathology in a new mouse model of Charcot-Marie-Tooth disease type 2E. Hum Mol Genet. 2011 Jul 01; 20(13):2535-48. PMID: 21493625; PMCID: PMC3109999.
      View in: PubMed, PubMed Central
    39. Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther. 2011 Jan; 336(1):87-94. PMID: 20884751; PMCID: PMC3014303.
      View in: PubMed, PubMed Central
    40. Calcutt NA. Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy. ASN Neuro. 2010 Sep 09; 2(4):e00042. PMID: 20842208; PMCID: PMC2936743.
      View in: PubMed, PubMed Central
    41. Davidson EP, Coppey LJ, Calcutt NA, Oltman CL, Yorek MA. Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction. Diabetes Metab Res Rev. 2010 May; 26(4):306-18. PMID: 20503263; PMCID: PMC2878284.
      View in: PubMed, PubMed Central
    42. Davidson E, Coppey L, Lu B, Arballo V, Calcutt NA, Gerard C, Yorek M. The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy. Exp Diabetes Res. 2009; 2009:431980. PMID: 20148083; PMCID: PMC2817866.
      View in: PubMed, PubMed Central
    43. Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt NA, Fernyhough P. Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes. 2010 Apr; 59(4):1082-91. PMID: 20103706; PMCID: PMC2844817.
      View in: PubMed, PubMed Central
    44. Fernyhough P, Calcutt NA. Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium. 2010 Feb; 47(2):130-9. PMID: 20034667; PMCID: PMC2834846.
      View in: PubMed, PubMed Central
    45. Calcutt NA, Lopez VL, Bautista AD, Mizisin LM, Torres BR, Shroads AL, Mizisin AP, Stacpoole PW. Peripheral neuropathy in rats exposed to dichloroacetate. J Neuropathol Exp Neurol. 2009 Sep; 68(9):985-93. PMID: 19680144; PMCID: PMC2741559.
      View in: PubMed, PubMed Central
    46. Malisza KL, Jones C, Gruwel ML, Foreman D, Fernyhough P, Calcutt NA. Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. J Magn Reson Imaging. 2009 Aug; 30(2):271-6. PMID: 19629995; PMCID: PMC2742673.
      View in: PubMed, PubMed Central
    47. Calcutt NA, Cooper ME, Kern TS, Schmidt AM. Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov. 2009 May; 8(5):417-29. PMID: 19404313.
      View in: PubMed
    48. Jolivalt CG, Mizisin LM, Nelson A, Cunha JM, Ramos KM, Bonke D, Calcutt NA. B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol. 2009 Jun 10; 612(1-3):41-7. PMID: 19393643.
      View in: PubMed
    49. Garcia ML, Rao MV, Fujimoto J, Garcia VB, Shah SB, Crum J, Gotow T, Uchiyama Y, Ellisman M, Calcutt NA, Cleveland DW. Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci. 2009 Feb 04; 29(5):1277-84. PMID: 19193875; PMCID: PMC2782950.
      View in: PubMed, PubMed Central
    50. Jolivalt CG, Lee CA, Ramos KM, Calcutt NA. Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. Pain. 2008 Nov 15; 140(1):48-57. PMID: 18755547; PMCID: PMC2593464.
      View in: PubMed, PubMed Central
    51. Beiswenger KK, Calcutt NA, Mizisin AP. Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice. Neurosci Lett. 2008 Sep 19; 442(3):267-72. PMID: 18619518; PMCID: PMC2610845.
      View in: PubMed, PubMed Central
    52. Cunha JM, Jolivalt CG, Ramos KM, Gregory JA, Calcutt NA, Mizisin AP. Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors. Metabolism. 2008 Jul; 57(7):873-81. PMID: 18555826; PMCID: PMC2518323.
      View in: PubMed, PubMed Central
    53. Jolivalt CG, Vu Y, Mizisin LM, Mizisin AP, Calcutt NA. Impaired prosaposin secretion during nerve regeneration in diabetic rats and protection of nerve regeneration by a prosaposin-derived peptide. J Neuropathol Exp Neurol. 2008 Jul; 67(7):702-10. PMID: 18596543; PMCID: PMC2748883.
      View in: PubMed, PubMed Central
    54. Beiswenger KK, Calcutt NA, Mizisin AP. Epidermal nerve fiber quantification in the assessment of diabetic neuropathy. Acta Histochem. 2008; 110(5):351-62. PMID: 18384843; PMCID: PMC2561960.
      View in: PubMed, PubMed Central
    55. Burdo JR, Chen Q, Calcutt NA, Schubert D. The pathological interaction between diabetes and presymptomatic Alzheimer's disease. Neurobiol Aging. 2009 Dec; 30(12):1910-7. PMID: 18372080.
      View in: PubMed
    56. Calcutt NA, Jolivalt CG, Fernyhough P. Growth factors as therapeutics for diabetic neuropathy. Curr Drug Targets. 2008 Jan; 9(1):47-59. PMID: 18220712.
      View in: PubMed
    57. Calcutt NA, Backonja MM. Pathogenesis of pain in peripheral diabetic neuropathy. Curr Diab Rep. 2007 Dec; 7(6):429-34. PMID: 18255005.
      View in: PubMed
    58. Landgraf RR, Garrett TJ, Calcutt NA, Stacpoole PW, Yost RA. MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue. Anal Chem. 2007 Nov 01; 79(21):8170-5. PMID: 17894472.
      View in: PubMed
    59. Jolivalt CG, Dacunha JM, Esch FS, Calcutt NA. Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. Eur J Pain. 2008 Jan; 12(1):76-81. PMID: 17466547.
      View in: PubMed
    60. Ramos KM, Jiang Y, Svensson CI, Calcutt NA. Pathogenesis of spinally mediated hyperalgesia in diabetes. Diabetes. 2007 Jun; 56(6):1569-76. PMID: 17287466.
      View in: PubMed
    61. Jiang Y, Calcutt NA, Ramos KM, Rames KM, Mizisin AP. Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic rats. J Peripher Nerv Syst. 2006 Dec; 11(4):274-85. PMID: 17117935.
      View in: PubMed
    62. Malmberg AB, O'Connor WT, Glennon JC, Ceseña R, Calcutt NA. Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats. Brain Res. 2006 Oct 18; 1115(1):48-53. PMID: 16920081.
      View in: PubMed
    63. Jolivalt CG, Jiang Y, Freshwater JD, Bartoszyk GD, Calcutt NA. Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats. Diabetologia. 2006 Nov; 49(11):2775-85. PMID: 16924480.
      View in: PubMed
    64. Calcutt NA, Freshwater JD, Hauptmann N, Taylor EM, Mizisin AP. Protection of sensory function in diabetic rats by Neotrofin. Eur J Pharmacol. 2006 Mar 18; 534(1-3):187-93. PMID: 16507305.
      View in: PubMed
    65. Jolivalt CG, Ramos KM, Herbetsson K, Esch FS, Calcutt NA. Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia. Pain. 2006 Mar; 121(1-2):14-21. PMID: 16480831.
      View in: PubMed
    66. Malmberg AB, Mizisin AP, Calcutt NA, von Stein T, Robbins WR, Bley KR. Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain. 2004 Oct; 111(3):360-7. PMID: 15363880.
      View in: PubMed
    67. Mizisin AP, Vu Y, Shuff M, Calcutt NA. Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats. Diabetes. 2004 Jul; 53(7):1807-12. PMID: 15220205.
      View in: PubMed
    68. Calcutt NA. Experimental models of painful diabetic neuropathy. J Neurol Sci. 2004 May 15; 220(1-2):137-9. PMID: 15140623.
      View in: PubMed
    69. Calcutt NA, Freshwater JD, Mizisin AP. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr; 47(4):718-24. PMID: 15298349.
      View in: PubMed
    70. Calcutt NA. Modeling diabetic sensory neuropathy in rats. Methods Mol Med. 2004; 99:55-65. PMID: 15131329.
      View in: PubMed
    71. Garcia ML, Lobsiger CS, Shah SB, Deerinck TJ, Crum J, Young D, Ward CM, Crawford TO, Gotow T, Uchiyama Y, Ellisman MH, Calcutt NA, Cleveland DW. NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol. 2003 Dec 08; 163(5):1011-20. PMID: 14662745; PMCID: PMC2173620.
      View in: PubMed, PubMed Central
    72. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. PMID: 12950462.
      View in: PubMed
    73. Sayers NM, Beswick LJ, Middlemas A, Calcutt NA, Mizisin AP, Tomlinson DR, Fernyhough P. Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats. Diabetes. 2003 Sep; 52(9):2372-80. PMID: 12941778.
      View in: PubMed
    74. Huang TJ, Price SA, Chilton L, Calcutt NA, Tomlinson DR, Verkhratsky A, Fernyhough P. Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes. 2003 Aug; 52(8):2129-36. PMID: 12882932.
      View in: PubMed
    75. Calcutt NA, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest. 2003 Feb; 111(4):507-14. PMID: 12588889; PMCID: PMC151919.
      View in: PubMed, PubMed Central
    76. Calcutt NA. Future treatments for diabetic neuropathy: clues from experimental neuropathy. Curr Diab Rep. 2002 Dec; 2(6):482-8. PMID: 12643154.
      View in: PubMed
    77. Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR. Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther. 2002 Dec; 303(3):1199-205. PMID: 12438544.
      View in: PubMed
    78. Rao MV, Garcia ML, Miyazaki Y, Gotow T, Yuan A, Mattina S, Ward CM, Calcutt NA, Uchiyama Y, Nixon RA, Cleveland DW. Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol. 2002 Aug 19; 158(4):681-93. PMID: 12186852.
      View in: PubMed
    79. Freshwater JD, Svensson CI, Malmberg AB, Calcutt NA. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Diabetes. 2002 Jul; 51(7):2249-55. PMID: 12086957.
      View in: PubMed
    80. Calcutt NA. Potential mechanisms of neuropathic pain in diabetes. Int Rev Neurobiol. 2002; 50:205-28. PMID: 12198811.
      View in: PubMed
    81. Mizisin AP, Steinhardt RC, O'Brien JS, Calcutt NA. TX14(A), a prosaposin-derived peptide, reverses established nerve disorders in streptozotocin-diabetic rats and prevents them in galactose-fed rats. J Neuropathol Exp Neurol. 2001 Oct; 60(10):953-60. PMID: 11589426.
      View in: PubMed
    82. Rende M, Brizi E, Donato R, Provenzano C, Bruno R, Mizisin AP, Garrett RS, Calcutt NA, Campana WM, O'Brien JS. Prosaposin is immunolocalized to muscle and prosaptides promote myoblast fusion and attenuate loss of muscle mass after nerve injury. Muscle Nerve. 2001 Jun; 24(6):799-808. PMID: 11360264.
      View in: PubMed
    83. Calcutt NA, Freshwater JD, O'Brien JS. Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiology. 2000 Nov; 93(5):1271-8. PMID: 11046216.
      View in: PubMed
    84. Campana WM, Mohiuddin L, Misasi R, O'Brien JS, Calcutt NA. Prosaposin-derived peptides enhanced sprouting of sensory neurons in vitro and induced sprouting at motor endplates in vivo. J Peripher Nerv Syst. 2000 Sep; 5(3):126-30. PMID: 11442168.
      View in: PubMed
    85. Calcutt NA, Stiller C, Gustafsson H, Malmberg AB. Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats. Brain Res. 2000 Feb 21; 856(1-2):20-7. PMID: 10677607.
      View in: PubMed
    86. Luo ZD, Chaplan SR, Scott BP, Cizkova D, Calcutt NA, Yaksh TL. Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development. J Neurosci. 1999 Nov 01; 19(21):9201-8. PMID: 10531423.
      View in: PubMed
    87. Calcutt NA, Campana WM, Eskeland NL, Mohiuddin L, Dines KC, Mizisin AP, O'Brien JS. Prosaposin gene expression and the efficacy of a prosaposin-derived peptide in preventing structural and functional disorders of peripheral nerve in diabetic rats. J Neuropathol Exp Neurol. 1999 Jun; 58(6):628-36. PMID: 10374753.
      View in: PubMed
    88. Ceseña RM, Calcutt NA. Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. Neurosci Lett. 1999 Mar 05; 262(2):101-4. PMID: 10203241.
      View in: PubMed
    89. Shelton GD, Calcutt NA, Garrett RS, Gu D, Sarvetnick N, Campana WM, Powell HC. Necrotizing myopathy induced by overexpression of interferon-gamma in transgenic mice. Muscle Nerve. 1999 Feb; 22(2):156-65. PMID: 10024128.
      View in: PubMed
    90. Dines KC, Calcutt NA, Nunag KD, Mizisin AP, Kalichman MW. Effects of hindlimb temperature on sciatic nerve laser Doppler vascular conductance in control and streptozotocin-diabetic rats. J Neurol Sci. 1999 Feb 01; 163(1):17-24. PMID: 10223405.
      View in: PubMed
    91. Mizisin AP, Calcutt NA, Tomlinson DR, Gallagher A, Fernyhough P. Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats. J Peripher Nerv Syst. 1999; 4(3-4):211-21. PMID: 10642089.
      View in: PubMed
    92. Calcutt NA, Chen P, Hua XY. Effects of diabetes on tissue content and evoked release of calcitonin gene-related peptide-like immunoreactivity from rat sensory nerves. Neurosci Lett. 1998 Oct 02; 254(3):129-32. PMID: 10214974.
      View in: PubMed
    93. Ng TF, Lee FK, Song ZT, Calcutt NA, Lee AY, Chung SS, Chung SK, Ng DT, Lee LW. Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice. Diabetes. 1998 Jun; 47(6):961-6. PMID: 9604875.
      View in: PubMed
    94. Calcutt NA, Dines KC, Ceseña RM. Effects of the peptide HP228 on nerve disorders in diabetic rats. Metabolism. 1998 Jun; 47(6):650-6. PMID: 9627361.
      View in: PubMed
    95. Campana WM, Eskeland N, Calcutt NA, Misasi R, Myers RR, O'Brien JS. Prosaptide prevents paclitaxel neurotoxicity. Neurotoxicology. 1998 Apr; 19(2):237-44. PMID: 9553960.
      View in: PubMed
    96. Calcutt NA, Chaplan SR. Spinal pharmacology of tactile allodynia in diabetic rats. Br J Pharmacol. 1997 Dec; 122(7):1478-82. PMID: 9421298; PMCID: PMC1565094.
      View in: PubMed, PubMed Central
    97. Mizisin AP, Bache M, DiStefano PS, Acheson A, Lindsay RM, Calcutt NA. BDNF attenuates functional and structural disorders in nerves of galactose-fed rats. J Neuropathol Exp Neurol. 1997 Dec; 56(12):1290-301. PMID: 9413278.
      View in: PubMed
    98. Hua XY, Calcutt NA, Malmberg AB. Neonatal capsaicin treatment abolishes formalin-induced spinal PGE2 release. Neuroreport. 1997 Jul 07; 8(9-10):2325-9. PMID: 9243634.
      View in: PubMed
    99. Mizisin AP, Li L, Calcutt NA. Sorbitol accumulation and transmembrane efflux in osmotically stressed JS1 schwannoma cells. Neurosci Lett. 1997 Jun 20; 229(1):53-6. PMID: 9224800.
      View in: PubMed
    100. Mizisin AP, Calcutt NA, DiStefano PS, Acheson A, Longo FM. Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats. Diabetes. 1997 Apr; 46(4):647-52. PMID: 9075806.
      View in: PubMed
    101. Malmberg AB, Hedner T, Fallgren B, Calcutt NA. The effect of alpha-trinositol (D-myo-inositol 1,2,6-trisphosphate) on formalin-evoked spinal amino acid and prostaglandin E2 levels. Brain Res. 1997 Jan 30; 747(1):160-4. PMID: 9042542.
      View in: PubMed
    102. Okuse K, Chaplan SR, McMahon SB, Luo ZD, Calcutt NA, Scott BP, Akopian AN, Wood JN. Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain. Mol Cell Neurosci. 1997; 10(3-4):196-207. PMID: 9532581.
      View in: PubMed
    103. Calcutt NA, Jorge MC, Yaksh TL, Chaplan SR. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain. 1996 Dec; 68(2-3):293-9. PMID: 9121817.
      View in: PubMed
    104. Brett FM, Kalichman MW, Calcutt NA, Mizisin AP. Effects of seven days of galactose feeding and aldose reductase inhibition on mast cells and vessel morphometry in rat sciatic nerve. J Neurol Sci. 1996 Sep 15; 141(1-2):6-12. PMID: 8880685.
      View in: PubMed
    105. Belai A, Calcutt NA, Carrington AL, Diemel LT, Tomlinson DR, Burnstock G. Enteric neuropeptides in streptozotocin-diabetic rats; effects of insulin and aldose reductase inhibition. J Auton Nerv Syst. 1996 May 06; 58(3):163-9. PMID: 8738309.
      View in: PubMed
    106. Mizisin AP, Li L, Perello M, Freshwater JD, Kalichman MW, Roux L, Calcutt NA. Polyol pathway and osmoregulation in JS1 Schwann cells grown in hyperglycemic and hyperosmotic conditions. Am J Physiol. 1996 Jan; 270(1 Pt 2):F90-7. PMID: 8769826.
      View in: PubMed
    107. Calcutt NA, Li L, Yaksh TL, Malmberg AB. Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. Eur J Pharmacol. 1995 Oct 16; 285(2):189-97. PMID: 8566138.
      View in: PubMed
    108. Gu D, Wogensen L, Calcutt NA, Xia C, Zhu S, Merlie JP, Fox HS, Lindstrom J, Powell HC, Sarvetnick N. Myasthenia gravis-like syndrome induced by expression of interferon gamma in the neuromuscular junction. J Exp Med. 1995 Feb 01; 181(2):547-57. PMID: 7836911; PMCID: PMC2191877.
      View in: PubMed, PubMed Central
    109. Kalichman MW, Powell HC, Calcutt NA, Mizisin AP. Mast cell degranulation and blood-nerve barrier permeability in rat sciatic nerve after 7 days of hyperglycemia. Am J Physiol. 1995 Feb; 268(2 Pt 2):H740-8. PMID: 7864200.
      View in: PubMed
    110. Calcutt NA, Malmberg AB, Yamamoto T, Yaksh TL. Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. Pain. 1994 Sep; 58(3):413-20. PMID: 7838591.
      View in: PubMed
    111. Calcutt NA, McMurray HF, Moorhouse DF, Bache M, Parthasarathy S, Powell HC, Mizisin AP. Inhibition of macrophage chemotaxis and peripheral nerve regeneration in normal and hyperglycemic rats by the aldose reductase inhibitor Tolrestat. Exp Neurol. 1994 Aug; 128(2):226-32. PMID: 8076666.
      View in: PubMed
    112. Calcutt NA, Mizisin AP, Kalichman MW. Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve. Eur J Pharmacol. 1994 Jan 04; 251(1):27-33. PMID: 8137868.
      View in: PubMed
    113. Calcutt NA, Mizisin AP, Yaksh TL. Impaired induction of vasoactive intestinal polypeptide after sciatic nerve injury in the streptozotocin-diabetic rat. J Neurol Sci. 1993 Nov; 119(2):154-61. PMID: 8277329.
      View in: PubMed
    114. Malmberg AB, Yaksh TL, Calcutt NA. Anti-nociceptive effects of the GM1 ganglioside derivative AGF 44 on the formalin test in normal and streptozotocin-diabetic rats. Neurosci Lett. 1993 Oct 14; 161(1):45-8. PMID: 8255545.
      View in: PubMed
    115. Carrington AL, Calcutt NA, Ettlinger CB, Gustafsson T, Tomlinson DR. Effects of treatment with myo-inositol or its 1,2,6-trisphosphate (PP56) on nerve conduction in streptozotocin-diabetes. Eur J Pharmacol. 1993 Jun 24; 237(2-3):257-63. PMID: 8365454.
      View in: PubMed
    116. Mizisin AP, Kalichman MW, Calcutt NA, Myers RR, Powell HC. Decreased endoneurial fluid electrolytes in normal rat sciatic nerve after aldose reductase inhibition. J Neurol Sci. 1993 May; 116(1):67-72. PMID: 8389817.
      View in: PubMed
    117. Kalichman MW, Calcutt NA. Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats. Anesthesiology. 1992 Nov; 77(5):941-7. PMID: 1443749.
      View in: PubMed
    118. Calcutt NA, Carrington AL, Ettlinger CB, Tomlinson DR. The effect of mixed bovine brain gangliosides on hypoxic conduction block in control and streptozotocin-diabetic rats. J Neurol Sci. 1992 May; 109(1):96-101. PMID: 1387680.
      View in: PubMed
    119. Calcutt NA, Muir D, Powell HC, Mizisin AP. Reduced ciliary neuronotrophic factor-like activity in nerves from diabetic or galactose-fed rats. Brain Res. 1992 Mar 20; 575(2):320-4. PMID: 1571789.
      View in: PubMed
    120. Mizisin AP, Calcutt NA. Dose-dependent alterations in nerve polyols and (Na+,K+)-ATPase activity in galactose intoxication. Metabolism. 1991 Nov; 40(11):1207-12. PMID: 1658547.
      View in: PubMed
    121. Willars GB, Calcutt NA, Tomlinson DR. Nerve conduction velocity and axonal transport of 6-phosphofructokinase activity in galactose-fed rats. J Neurol Sci. 1991 Jul; 104(1):46-51. PMID: 1717661.
      View in: PubMed
    122. Carrington AL, Ettlinger CB, Calcutt NA, Tomlinson DR. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun; 34(6):397-401. PMID: 1653157.
      View in: PubMed
    123. Calcutt NA, Ettlinger CB, Carrington AL, Diemel L, Tomlinson DR. Resistance to hypoxic conduction block in sciatic nerves of rats with streptozotocin-induced diabetes mellitus. J Neurol Sci. 1991 May; 103(1):116-23. PMID: 1865225.
      View in: PubMed
    124. Calcutt NA, Tomlinson DR, Biswas S. Coexistence of nerve conduction deficit with increased Na(+)-K(+)-ATPase activity in galactose-fed mice. Implications for polyol pathway and diabetic neuropathy. Diabetes. 1990 Jun; 39(6):663-6. PMID: 2161366.
      View in: PubMed
    125. Calcutt NA, Tomlinson DR, Willars GB, Keen P. Axonal transport of substance P-like immunoreactivity in ganglioside-treated diabetic rats. J Neurol Sci. 1990 May; 96(2-3):283-91. PMID: 1695917.
      View in: PubMed
    126. Willars GB, Calcutt NA, Compton AM, Tomlinson DR, Keen P. Substance P levels in peripheral nerve, skin, atrial myocardium and gastrointestinal tract of rats with long-term diabetes mellitus. Effects of aldose reductase inhibition. J Neurol Sci. 1989 Jun; 91(1-2):153-64. PMID: 2473171.
      View in: PubMed
    127. Tomlinson DR, Willars GB, Calcutt NA, Compton AM, Macdonald IA, Clarke HE, Keen P. Effects of sorbinil treatment in rats with chronic streptozotocin-diabetes; changes in lens and in substance P and catecholamines in the iris. Curr Eye Res. 1989 Apr; 8(4):357-63. PMID: 2470551.
      View in: PubMed
    128. Calcutt NA, Willars GB, Tomlinson DR. Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice. Muscle Nerve. 1988 Dec; 11(12):1206-10. PMID: 2467203.
      View in: PubMed
    129. Lambourne JE, Brown AM, Calcutt N, Tomlinson DR, Willars GB. Adenosine triphosphatase in nerves and ganglia of rats with streptozotocin-induced diabetes or galactosaemia; effects of aldose reductase inhibition. Diabetologia. 1988 Jun; 31(6):379-84. PMID: 2970984.
      View in: PubMed
    130. Calcutt NA, Tomlinson DR, Willars GB. Ganglioside treatment of streptozotocin-diabetic rats prevents defective axonal transport of 6-phosphofructokinase activity. J Neurochem. 1988 May; 50(5):1478-83. PMID: 2452237.
      View in: PubMed
    131. Calcutt NA, Willars GB, Tomlinson DR. Statil-sensitive polyol formation in nerve of galactose-fed mice. Metabolism. 1988 May; 37(5):450-3. PMID: 3130544.
      View in: PubMed
    132. Calcutt NA, Tomlinson DR, Willars GB. Ganglioside treatment of diabetic rats; effects on nerve adenosine triphosphatase activity and motor nerve conduction velocity. Life Sci. 1988; 42(16):1515-20. PMID: 2965293.
      View in: PubMed
    133. Willars GB, Calcutt NA, Tomlinson DR. Reduced anterograde and retrograde accumulation of axonally transported phosphofructokinase in streptozotocin-diabetic rats: effects of insulin and the aldose reductase inhibitor 'Statil'. Diabetologia. 1987 Apr; 30(4):239-43. PMID: 2439402.
      View in: PubMed
    Nigel's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (498) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (11) people
    _
    Similar People
    People who share similar concepts with this person.
    See all (60) people
    _
    Same Department
    Search Department
    ↑