Nigel Calcutt

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Selection of a lead LPAR1 antagonist for treatment of diabetic neuropathy
    NIH R44DK127879May 20, 2021 - Apr 30, 2023
    Role: Co-Principal Investigator
    Development of a topical fixed-dose combination drug for peripheral neuropathic pain.
    NIH R41NS120354Sep 30, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    Muscarinic receptor antagonists as a therapy for diabetic neuropathy
    NIH R21DK102032Aug 1, 2014 - Jul 31, 2017
    Role: Principal Investigator
    Cholinergic constraint and diabetic neuropathy
    NIH R01NS081082Jul 1, 2013 - Jun 30, 2019
    Role: Principal Investigator
    Non Phamacologic Treatments for Diabetic Neuropathy
    NIH R21NS062346Feb 1, 2009 - Jan 31, 2012
    Role: Principal Investigator
    Near Infra Red Energy To Treat Diabetic Neuropathy
    NIH R21NS050232Jul 1, 2005 - Jun 30, 2007
    Role: Principal Investigator
    Mechanisms of Spinally-Mediated Hyperalgesia in Diabetes
    NIH R01DK057629Apr 1, 2000 - Jul 31, 2014
    Role: Principal Investigator
    NIH R01NS038855Sep 30, 1999 - Aug 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine. Front Neurol. 2021; 12:663373. Han MM, Frizzi KE, Ellis RJ, Calcutt NA, Fields JA. PMID: 34211430.
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    2. Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals (Diabetes Metab J 2021;45:27-42). Diabetes Metab J. 2021 May; 45(3):457-458. Jin HY, Moon SS, Calcutt NA. PMID: 34044488.
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    3. Novel and Emerging Electrophysiological Biomarkers of Diabetic Neuropathy and Painful Diabetic Neuropathy. Clin Ther. 2021 Apr 24. Marshall A, Alam U, Themistocleous A, Calcutt N, Marshall A. PMID: 33906790.
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    4. Pharmacological Modulation of Rate-Dependent Depression of the Spinal H-Reflex Predicts Therapeutic Efficacy against Painful Diabetic Neuropathy. Diagnostics (Basel). 2021 Feb 11; 11(2). Lee-Kubli CA, Zhou X, Jolivalt CG, Calcutt NA. PMID: 33670344.
      View in: PubMed   Mentions:
    5. Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals. Diabetes Metab J. 2021 Jan; 45(1):27-42. Jin HY, Moon SS, Calcutt NA. PMID: 33307618.
      View in: PubMed   Mentions:
    6. Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system. Expert Rev Neurother. 2021 Jan; 21(1):45-63. Demaré S, Kothari A, Calcutt NA, Fernyhough P. PMID: 33161784.
      View in: PubMed   Mentions: 2     Fields:    
    7. Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice. Proc Natl Acad Sci U S A. 2020 10 20; 117(42):26482-26493. Bonomo RR, Cook TM, Gavini CK, White CR, Jones JR, Bovo E, Zima AV, Brown IA, Dugas LR, Zakharian E, Aubert G, Alonzo F, Calcutt NA, Mansuy-Aubert V. PMID: 33020290.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    8. Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms? Pain. 2020 09; 161(Suppl 1):S65-S86. Calcutt NA. PMID: 32999525.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. A missense point mutation in nerve growth factor (NGFR100W) results in selective peripheral sensory neuropathy. Prog Neurobiol. 2020 11; 194:101886. Yang W, Sung K, Xu W, Rodriguez MJ, Wu AC, Santos SA, Fang S, Uber RK, Dong SX, Guillory BC, Orain X, Raus J, Jolivalt C, Calcutt N, Rissman RA, Ding J, Wu C. PMID: 32693191.
      View in: PubMed   Mentions:    Fields:    
    10. Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV. Ann Clin Transl Neurol. 2020 07; 7(7):1166-1173. Ellis RJ, Diaz M, Sacktor N, Marra C, Collier AC, Clifford DB, Calcutt N, Fields JA, Heaton RK, Letendre SL, CNS Antiretroviral Therapy Effects Research (CHARTER) Study Group . PMID: 32619341.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Translating diabetic peripheral neuropathy. J Peripher Nerv Syst. 2020 06; 25(2):64-65. Malik RA, Calcutt NA. PMID: 32394617.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice. J Pharmacol Exp Ther. 2020 07; 374(1):44-51. Jolivalt CG, Frizzi KE, Han MM, Mota AJ, Guernsey LS, Kotra LP, Fernyhough P, Calcutt NA. PMID: 32327528.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Muscarinic Toxin 7 Signals Via Ca2+/Calmodulin-Dependent Protein Kinase Kinase ß to Augment Mitochondrial Function and Prevent Neurodegeneration. Mol Neurobiol. 2020 Jun; 57(6):2521-2538. Saleh A, Sabbir MG, Aghanoori MR, Smith DR, Roy Chowdhury SK, Tessler L, Brown J, Gedarevich E, Kassahun MZ, Frizzi K, Calcutt NA, Fernyhough P. PMID: 32198698.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice. Sci Rep. 2019 11 20; 9(1):17158. Fields JA, Swinton MK, Carson A, Soontornniyomkij B, Lindsay C, Han MM, Frizzi K, Sambhwani S, Murphy A, Achim CL, Ellis RJ, Calcutt NA. PMID: 31748578.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189. Diabetes. 2019 11; 68(11):2143-2154. Jolivalt CG, Marquez A, Quach D, Navarro Diaz MC, Anaya C, Kifle B, Muttalib N, Sanchez G, Guernsey L, Hefferan M, Smith DR, Fernyhough P, Johe K, Calcutt NA. PMID: 31492662.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Dichloroacetate-induced peripheral neuropathy. Int Rev Neurobiol. 2019; 145:211-238. Stacpoole PW, Martyniuk CJ, James MO, Calcutt NA. PMID: 31208525.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    17. Preface. Int Rev Neurobiol. 2019; 145:xi-xii. Fernyhough P, Calcutt NA. PMID: 31208529.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments. J Diabetes Res. 2018; 2018:5378439. Yorek M, Malik RA, Calcutt NA, Vinik A, Yagihashi S. PMID: 30648115.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    19. Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes. Mol Metab. 2019 02; 20:149-165. Aghanoori MR, Smith DR, Shariati-Ievari S, Ajisebutu A, Nguyen A, Desmond F, Jesus CHA, Zhou X, Calcutt NA, Aliani M, Fernyhough P. PMID: 30545741.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons. Front Neurosci. 2018; 12:402. Sabbir MG, Calcutt NA, Fernyhough P. PMID: 29997469.
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    21. Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons. Exp Neurol. 2018 08; 306:158-168. Villalón E, Barry DM, Byers N, Frizzi K, Jones MR, Landayan DS, Dale JM, Downer NL, Calcutt NA, Garcia ML. PMID: 29772247.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. The H-Reflex as a Biomarker for Spinal Disinhibition in Painful Diabetic Neuropathy. Curr Diab Rep. 2018 01 23; 18(1):1. Lee-Kubli C, Marshall AG, Malik RA, Calcutt NA. PMID: 29362940.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    23. A novel curcumin derivative for the treatment of diabetic neuropathy. Neuropharmacology. 2018 Feb; 129:26-35. Daugherty DJ, Marquez A, Calcutt NA, Schubert D. PMID: 29122628.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats. Exp Neurol. 2017 11; 297:148-157. Aghanoori MR, Smith DR, Roy Chowdhury S, Sabbir MG, Calcutt NA, Fernyhough P. PMID: 28803751.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Differential effects of myostatin deficiency on motor and sensory axons. Muscle Nerve. 2017 Dec; 56(6):E100-E107. Jones MR, Villalón E, Northcutt AJ, Calcutt NA, Garcia ML. PMID: 28073155.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Diabetes. 2017 05; 66(5):1380-1390. Marshall AG, Lee-Kubli C, Azmi S, Zhang M, Ferdousi M, Mixcoatl-Zecuatl T, Petropoulos IN, Ponirakis G, Fineman MS, Fadavi H, Frizzi K, Tavakoli M, Jeziorska M, Jolivalt CG, Boulton AJM, Efron N, Calcutt NA, Malik RA. PMID: 28202580.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    27. Schwann cell interactions with axons and microvessels in diabetic neuropathy. Nat Rev Neurol. 2017 03; 13(3):135-147. Gonçalves NP, Vægter CB, Andersen H, Østergaard L, Calcutt NA, Jensen TS. PMID: 28134254.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    28. Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. J Clin Invest. 2017 Feb 01; 127(2):608-622. Calcutt NA, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P. PMID: 28094765.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Peripheral Neuropathy in Mouse Models of Diabetes. Curr Protoc Mouse Biol. 2016 Sep 01; 6(3):223-255. Jolivalt CG, Frizzi KE, Guernsey L, Marquez A, Ochoa J, Rodriguez M, Calcutt NA. PMID: 27584552.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    30. A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:3-8. Calcutt NA, Fernyhough P. PMID: 27133141.
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    31. An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:45-52. Calcutt NA, Fernyhough P. PMID: 27133144.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    32. The a5 subunit containing GABAA receptors contribute to chronic pain. Pain. 2016 Mar; 157(3):613-626. Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt NA, Delgado-Lezama R, Marsala M, Granados-Soto V. PMID: 26545088.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    33. Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7214-23. Rocca CJ, Kreymerman A, Ur SN, Frizzi KE, Naphade S, Lau A, Tran T, Calcutt NA, Goldberg JL, Cherqui S. PMID: 26540660.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    34. Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery. Nat Commun. 2015 Jan 19; 6:6079. Hollis ER, Ishiko N, Pessian M, Tolentino K, Lee-Kubli CA, Calcutt NA, Zou Y. PMID: 25597627.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    35. A novel and robust conditioning lesion induced by ethidium bromide. Exp Neurol. 2015 Mar; 265:30-9. Hollis ER, Ishiko N, Tolentino K, Doherty E, Rodriguez MJ, Calcutt NA, Zou Y. PMID: 25541322.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    36. Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents. Cell Mol Neurobiol. 2014 Jul; 34(5):643-9. Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, Calcutt NA, Fernyhough P. PMID: 24682898.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRa/RET receptor signaling. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2325-30. Hedstrom KL, Murtie JC, Albers K, Calcutt NA, Corfas G. PMID: 24449858.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Painful neuropathy: Mechanisms. Handb Clin Neurol. 2014; 126:533-57. Lee-Kubli CA, Calcutt NA. PMID: 25410243.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    39. Animal models of diabetes-induced neuropathic pain. Curr Top Behav Neurosci. 2014; 20:147-70. Lee-Kubli CA, Mixcoatl-Zecuatl T, Jolivalt CG, Calcutt NA. PMID: 24510303.
      View in: PubMed   Mentions: 8     Fields:    
    40. Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst. 2013 Dec; 18(4):306-15. Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt NA. PMID: 24147903.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    41. Location, location, location?: is the pain of diabetic neuropathy generated by hyperactive sensory neurons? Diabetes. 2013 Nov; 62(11):3658-60. Calcutt NA. PMID: 24158992.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain. Pain. 2014 Feb; 155(2):250-260. Lee-Kubli CAG, Calcutt NA. PMID: 24103402.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    43. Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy. J Med Chem. 2013 Jun 27; 56(12):5071-8. Hadimani MB, Purohit MK, Vanampally C, Van der Ploeg R, Arballo V, Morrow D, Frizzi KE, Calcutt NA, Fernyhough P, Kotra LP. PMID: 23758573.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. Ciliary neurotrophic factor activates NF-?B to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents. Neuropharmacology. 2013 Feb; 65:65-73. Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi KE, Calcutt NA, Fernyhough P. PMID: 23022047.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    45. Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats. Acta Neuropathol. 2012 Oct; 124(4):561-73. Gregory JA, Jolivalt CG, Goor J, Mizisin AP, Calcutt NA. PMID: 22791295.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    46. Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes. Brain. 2012 Jun; 135(Pt 6):1751-66. Roy Chowdhury SK, Smith DR, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt NA, Fernyhough P. PMID: 22561641.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    47. Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness. J Neurosci. 2012 May 02; 32(18):6209-19. Barry DM, Stevenson W, Bober BG, Wiese PJ, Dale JM, Barry GS, Byers NS, Strope JD, Chang R, Schulz DJ, Shah S, Calcutt NA, Gebremichael Y, Garcia ML. PMID: 22553027.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    48. Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging. Rapid Commun Mass Spectrom. 2011 Oct 30; 25(20):3178-84. Landgraf RR, Garrett TJ, Conaway MC, Calcutt NA, Stacpoole PW, Yost RA. PMID: 21953974.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    49. Muscle pathology without severe nerve pathology in a new mouse model of Charcot-Marie-Tooth disease type 2E. Hum Mol Genet. 2011 Jul 01; 20(13):2535-48. Shen H, Barry DM, Dale JM, Garcia VB, Calcutt NA, Garcia ML. PMID: 21493625.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    50. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther. 2011 Jan; 336(1):87-94. Li W, James MO, McKenzie SC, Calcutt NA, Liu C, Stacpoole PW. PMID: 20884751.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    51. Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy. ASN Neuro. 2010 Sep 09; 2(4):e00042. Calcutt NA. PMID: 20842208.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    52. Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction. Diabetes Metab Res Rev. 2010 May; 26(4):306-18. Davidson EP, Coppey LJ, Calcutt NA, Oltman CL, Yorek MA. PMID: 20503263.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    53. The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy. Exp Diabetes Res. 2009; 2009:431980. Davidson E, Coppey L, Lu B, Arballo V, Calcutt NA, Gerard C, Yorek M. PMID: 20148083.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    54. Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes. 2010 Apr; 59(4):1082-91. Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt NA, Fernyhough P. PMID: 20103706.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    55. Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium. 2010 Feb; 47(2):130-9. Fernyhough P, Calcutt NA. PMID: 20034667.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    56. Peripheral neuropathy in rats exposed to dichloroacetate. J Neuropathol Exp Neurol. 2009 Sep; 68(9):985-93. Calcutt NA, Lopez VL, Bautista AD, Mizisin LM, Torres BR, Shroads AL, Mizisin AP, Stacpoole PW. PMID: 19680144.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    57. Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. J Magn Reson Imaging. 2009 Aug; 30(2):271-6. Malisza KL, Jones C, Gruwel ML, Foreman D, Fernyhough P, Calcutt NA. PMID: 19629995.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    58. Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov. 2009 May; 8(5):417-29. Calcutt NA, Cooper ME, Kern TS, Schmidt AM. PMID: 19404313.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimals
    59. B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol. 2009 Jun 10; 612(1-3):41-7. Jolivalt CG, Mizisin LM, Nelson A, Cunha JM, Ramos KM, Bonke D, Calcutt NA. PMID: 19393643.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    60. Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci. 2009 Feb 04; 29(5):1277-84. Garcia ML, Rao MV, Fujimoto J, Garcia VB, Shah SB, Crum J, Gotow T, Uchiyama Y, Ellisman M, Calcutt NA, Cleveland DW. PMID: 19193875.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    61. Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. Pain. 2008 Nov 15; 140(1):48-57. Jolivalt CG, Lee CA, Ramos KM, Calcutt NA. PMID: 18755547.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    62. Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice. Neurosci Lett. 2008 Sep 19; 442(3):267-72. Beiswenger KK, Calcutt NA, Mizisin AP. PMID: 18619518.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    63. Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors. Metabolism. 2008 Jul; 57(7):873-81. Cunha JM, Jolivalt CG, Ramos KM, Gregory JA, Calcutt NA, Mizisin AP. PMID: 18555826.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    64. Impaired prosaposin secretion during nerve regeneration in diabetic rats and protection of nerve regeneration by a prosaposin-derived peptide. J Neuropathol Exp Neurol. 2008 Jul; 67(7):702-10. Jolivalt CG, Vu Y, Mizisin LM, Mizisin AP, Calcutt NA. PMID: 18596543.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    65. Epidermal nerve fiber quantification in the assessment of diabetic neuropathy. Acta Histochem. 2008; 110(5):351-62. Beiswenger KK, Calcutt NA, Mizisin AP. PMID: 18384843.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    66. The pathological interaction between diabetes and presymptomatic Alzheimer's disease. Neurobiol Aging. 2009 Dec; 30(12):1910-7. Burdo JR, Chen Q, Calcutt NA, Schubert D. PMID: 18372080.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    67. Growth factors as therapeutics for diabetic neuropathy. Curr Drug Targets. 2008 Jan; 9(1):47-59. Calcutt NA, Jolivalt CG, Fernyhough P. PMID: 18220712.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    68. Pathogenesis of pain in peripheral diabetic neuropathy. Curr Diab Rep. 2007 Dec; 7(6):429-34. Calcutt NA, Backonja MM. PMID: 18255005.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    69. MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue. Anal Chem. 2007 Nov 01; 79(21):8170-5. Landgraf RR, Garrett TJ, Calcutt NA, Stacpoole PW, Yost RA. PMID: 17894472.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    70. Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. Eur J Pain. 2008 Jan; 12(1):76-81. Jolivalt CG, Dacunha JM, Esch FS, Calcutt NA. PMID: 17466547.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    71. Pathogenesis of spinally mediated hyperalgesia in diabetes. Diabetes. 2007 Jun; 56(6):1569-76. Ramos KM, Jiang Y, Svensson CI, Calcutt NA. PMID: 17287466.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    72. Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic rats. J Peripher Nerv Syst. 2006 Dec; 11(4):274-85. Jiang Y, Calcutt NA, Ramos KM, Rames KM, Mizisin AP. PMID: 17117935.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    73. Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats. Brain Res. 2006 Oct 18; 1115(1):48-53. Malmberg AB, O'Connor WT, Glennon JC, Ceseña R, Calcutt NA. PMID: 16920081.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    74. Protection of sensory function in diabetic rats by Neotrofin. Eur J Pharmacol. 2006 Mar 18; 534(1-3):187-93. Calcutt NA, Freshwater JD, Hauptmann N, Taylor EM, Mizisin AP. PMID: 16507305.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    75. Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia. Pain. 2006 Mar; 121(1-2):14-21. Jolivalt CG, Ramos KM, Herbetsson K, Esch FS, Calcutt NA. PMID: 16480831.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    76. Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain. 2004 Oct; 111(3):360-367. Malmberg AB, Mizisin AP, Calcutt NA, von Stein T, Robbins WR, Bley KR. PMID: 15363880.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    77. Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats. Diabetes. 2004 Jul; 53(7):1807-12. Mizisin AP, Vu Y, Shuff M, Calcutt NA. PMID: 15220205.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    78. Experimental models of painful diabetic neuropathy. J Neurol Sci. 2004 May 15; 220(1-2):137-9. Calcutt NA. PMID: 15140623.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    79. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr; 47(4):718-24. Calcutt NA, Freshwater JD, Mizisin AP. PMID: 15298349.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    80. Modeling diabetic sensory neuropathy in rats. Methods Mol Med. 2004; 99:55-65. Calcutt NA. PMID: 15131329.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    81. NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol. 2003 Dec 08; 163(5):1011-20. Garcia ML, Lobsiger CS, Shah SB, Deerinck TJ, Crum J, Young D, Ward CM, Crawford TO, Gotow T, Uchiyama Y, Ellisman MH, Calcutt NA, Cleveland DW. PMID: 14662745.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    82. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. PMID: 12950462.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    83. Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats. Diabetes. 2003 Sep; 52(9):2372-80. Sayers NM, Beswick LJ, Middlemas A, Calcutt NA, Mizisin AP, Tomlinson DR, Fernyhough P. PMID: 12941778.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    84. Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes. 2003 Aug; 52(8):2129-36. Huang TJ, Price SA, Chilton L, Calcutt NA, Tomlinson DR, Verkhratsky A, Fernyhough P. PMID: 12882932.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    85. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest. 2003 Feb; 111(4):507-14. Calcutt NA, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR. PMID: 12588889.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    86. Future treatments for diabetic neuropathy: clues from experimental neuropathy. Curr Diab Rep. 2002 Dec; 2(6):482-8. Calcutt NA. PMID: 12643154.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    87. Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol. 2002 Aug 19; 158(4):681-93. Rao MV, Garcia ML, Miyazaki Y, Gotow T, Yuan A, Mattina S, Ward CM, Calcutt NA, Uchiyama Y, Nixon RA, Cleveland DW. PMID: 12186852.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    88. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Diabetes. 2002 Jul; 51(7):2249-55. Freshwater JD, Svensson CI, Malmberg AB, Calcutt NA. PMID: 12086957.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    89. Potential mechanisms of neuropathic pain in diabetes. Int Rev Neurobiol. 2002; 50:205-28. Calcutt NA. PMID: 12198811.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    90. Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiology. 2000 Nov; 93(5):1271-8. Calcutt NA, Freshwater JD, O'Brien JS. PMID: 11046216.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    91. Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats. Brain Res. 2000 Feb 21; 856(1-2):20-7. Calcutt NA, Stiller C, Gustafsson H, Malmberg AB. PMID: 10677607.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    92. Effects of diabetes on tissue content and evoked release of calcitonin gene-related peptide-like immunoreactivity from rat sensory nerves. Neurosci Lett. 1998 Oct 02; 254(3):129-32. Calcutt NA, Chen P, Hua XY. PMID: 10214974.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    93. Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. Pain. 1994 Sep; 58(3):413-420. Calcutt NA, Malmberg AB, Yamamoto T, Yaksh TL. PMID: 7838591.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
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