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Nigel Calcutt

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0612
La Jolla CA 92093
Phone858-534-5331
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    Collapse Research 
    Collapse Research Activities and Funding
    Muscarinic receptor antagonists as a therapy for diabetic neuropathy
    NIH/NIDDK R21DK102032Aug 1, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Cholinergic constraint and diabetic neuropathy
    NIH/NINDS R01NS081082Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Non Phamacologic Treatments for Diabetic Neuropathy
    NIH/NINDS R21NS062346Feb 1, 2009 - Jan 31, 2012
    Role: Principal Investigator
    Near Infra Red Energy To Treat Diabetic Neuropathy
    NIH/NINDS R21NS050232Jul 1, 2005 - Jun 30, 2007
    Role: Principal Investigator
    Mechanisms of Spinally-Mediated Hyperalgesia in Diabetes
    NIH/NIDDK R01DK057629Apr 1, 2000 - Jul 31, 2014
    Role: Principal Investigator
    PROSAPOSIN AND PROSAPTIDES IN DIABETIC NEUROPATHY
    NIH/NINDS R01NS038855Sep 30, 1999 - Aug 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Villalón E, Barry DM, Byers N, Frizzi K, Jones MR, Landayan DS, Dale JM, Downer NL, Calcutt N, Garcia ML. Internode length is reduced during myelination and remyelination by neurofilament medium phosphorylation in motor axons. Exp Neurol. 2018 May 14; 306:158-168. PMID: 29772247.
      View in: PubMed
    2. Lee-Kubli C, Marshall AG, Malik RA, Calcutt N. The H-Reflex as a Biomarker for Spinal Disinhibition in Painful Diabetic Neuropathy. Curr Diab Rep. 2018 Jan 23; 18(1):1. PMID: 29362940.
      View in: PubMed
    3. Daugherty DJ, Marquez A, Calcutt N, Schubert D. A novel curcumin derivative for the treatment of diabetic neuropathy. Neuropharmacology. 2018 Feb; 129:26-35. PMID: 29122628.
      View in: PubMed
    4. Aghanoori MR, Smith DR, Roy Chowdhury S, Sabbir MG, Calcutt N, Fernyhough P. Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats. Exp Neurol. 2017 11; 297:148-157. PMID: 28803751.
      View in: PubMed
    5. Jones MR, Villalón E, Northcutt AJ, Calcutt N, Garcia ML. Differential effects of myostatin deficiency on motor and sensory axons. Muscle Nerve. 2017 Dec; 56(6):E100-E107. PMID: 28073155.
      View in: PubMed
    6. Marshall AG, Lee-Kubli C, Azmi S, Zhang M, Ferdousi M, Mixcoatl-Zecuatl T, Petropoulos IN, Ponirakis G, Fineman MS, Fadavi H, Frizzi K, Tavakoli M, Jeziorska M, Jolivalt CG, Boulton AJM, Efron N, Calcutt N, Malik RA. Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy. Diabetes. 2017 05; 66(5):1380-1390. PMID: 28202580.
      View in: PubMed
    7. Gonçalves NP, Vægter CB, Andersen H, Østergaard L, Calcutt N, Jensen TS. Schwann cell interactions with axons and microvessels in diabetic neuropathy. Nat Rev Neurol. 2017 Mar; 13(3):135-147. PMID: 28134254.
      View in: PubMed
    8. Calcutt N, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P. Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. J Clin Invest. 2017 Feb 01; 127(2):608-622. PMID: 28094765.
      View in: PubMed
    9. Jolivalt CG, Frizzi KE, Guernsey L, Marquez A, Ochoa J, Rodriguez M, Calcutt N. Peripheral Neuropathy in Mouse Models of Diabetes. Curr Protoc Mouse Biol. 2016 Sep 01; 6(3):223-55. PMID: 27584552; PMCID: PMC5023323 [Available on 09/01/17].
    10. Calcutt N, Fernyhough P. A Brief Introduction to the History and Controversies of Clinical Trials in Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:3-8. PMID: 27133141.
      View in: PubMed
    11. Calcutt N, Fernyhough P. An Introduction to the History and Controversies of Animal Models of Diabetic Neuropathy. Int Rev Neurobiol. 2016; 127:45-52. PMID: 27133144.
      View in: PubMed
    12. Bravo-Hernández M, Corleto JA, Barragán-Iglesias P, González-Ramírez R, Pineda-Farias JB, Felix R, Calcutt N, Delgado-Lezama R, Marsala M, Granados-Soto V. The a5 subunit containing GABAA receptors contribute to chronic pain. Pain. 2016 Mar; 157(3):613-26. PMID: 26545088; PMCID: PMC4950669 [Available on 03/01/17].
    13. Rocca CJ, Kreymerman A, Ur SN, Frizzi KE, Naphade S, Lau A, Tran T, Calcutt N, Goldberg JL, Cherqui S. Treatment of Inherited Eye Defects by Systemic Hematopoietic Stem Cell Transplantation. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7214-23. PMID: 26540660; PMCID: PMC4640476.
    14. Hollis ER, Ishiko N, Pessian M, Tolentino K, Lee-Kubli CA, Calcutt N, Zou Y. Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery. Nat Commun. 2015 Jan 19; 6:6079. PMID: 25597627; PMCID: PMC4831586.
    15. Hollis ER, Ishiko N, Tolentino K, Doherty E, Rodriguez MJ, Calcutt N, Zou Y. A novel and robust conditioning lesion induced by ethidium bromide. Exp Neurol. 2015 Mar; 265:30-9. PMID: 25541322; PMCID: PMC4346483.
    16. Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, Calcutt N, Fernyhough P. Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the JAK/STAT pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents. Cell Mol Neurobiol. 2014 Jul; 34(5):643-9. PMID: 24682898.
      View in: PubMed
    17. Hedstrom KL, Murtie JC, Albers K, Calcutt N, Corfas G. Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRa/RET receptor signaling. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2325-30. PMID: 24449858; PMCID: PMC3926041.
    18. Lee-Kubli CA, Calcutt N. Painful neuropathy: Mechanisms. Handb Clin Neurol. 2014; 126:533-57. PMID: 25410243.
      View in: PubMed
    19. Lee-Kubli CA, Mixcoatl-Zecuatl T, Jolivalt CG, Calcutt N. Animal models of diabetes-induced neuropathic pain. Curr Top Behav Neurosci. 2014; 20:147-70. PMID: 24510303.
      View in: PubMed
    20. Chen DK, Frizzi KE, Guernsey LS, Ladt K, Mizisin AP, Calcutt N. Repeated monitoring of corneal nerves by confocal microscopy as an index of peripheral neuropathy in type-1 diabetic rodents and the effects of topical insulin. J Peripher Nerv Syst. 2013 Dec; 18(4):306-15. PMID: 24147903; PMCID: PMC3981941.
    21. Calcutt N. Location, location, location?: is the pain of diabetic neuropathy generated by hyperactive sensory neurons? Diabetes. 2013 Nov; 62(11):3658-60. PMID: 24158992; PMCID: PMC3806595.
    22. Lee-Kubli CA, Calcutt N. Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain. Pain. 2014 Feb; 155(2):250-60. PMID: 24103402; PMCID: PMC3946970.
    23. Hadimani MB, Purohit MK, Vanampally C, Van der Ploeg R, Arballo V, Morrow D, Frizzi KE, Calcutt N, Fernyhough P, Kotra LP. Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy. J Med Chem. 2013 Jun 27; 56(12):5071-8. PMID: 23758573.
      View in: PubMed
    24. Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Tessler L, Martens C, Morrow D, Schartner E, Frizzi KE, Calcutt N, Fernyhough P. Ciliary neurotrophic factor activates NF-?B to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents. Neuropharmacology. 2013 Feb; 65:65-73. PMID: 23022047; PMCID: PMC3521091.
    25. Gregory JA, Jolivalt CG, Goor J, Mizisin AP, Calcutt N. Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats. Acta Neuropathol. 2012 Oct; 124(4):561-73. PMID: 22791295.
      View in: PubMed
    26. Roy Chowdhury SK, Smith DR, Saleh A, Schapansky J, Marquez A, Gomes S, Akude E, Morrow D, Calcutt N, Fernyhough P. Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes. Brain. 2012 Jun; 135(Pt 6):1751-66. PMID: 22561641; PMCID: PMC3359752.
    27. Barry DM, Stevenson W, Bober BG, Wiese PJ, Dale JM, Barry GS, Byers NS, Strope JD, Chang R, Schulz DJ, Shah S, Calcutt N, Gebremichael Y, Garcia ML. Expansion of neurofilament medium C terminus increases axonal diameter independent of increases in conduction velocity or myelin thickness. J Neurosci. 2012 May 02; 32(18):6209-19. PMID: 22553027; PMCID: PMC3363292.
    28. Landgraf RR, Garrett TJ, Conaway MC, Calcutt N, Stacpoole PW, Yost RA. Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging. Rapid Commun Mass Spectrom. 2011 Oct 30; 25(20):3178-84. PMID: 21953974; PMCID: PMC3926214.
    29. Shen H, Barry DM, Dale JM, Garcia VB, Calcutt N, Garcia ML. Muscle pathology without severe nerve pathology in a new mouse model of Charcot-Marie-Tooth disease type 2E. Hum Mol Genet. 2011 Jul 01; 20(13):2535-48. PMID: 21493625; PMCID: PMC3109999.
    30. Li W, James MO, McKenzie SC, Calcutt N, Liu C, Stacpoole PW. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther. 2011 Jan; 336(1):87-94. PMID: 20884751; PMCID: PMC3014303.
    31. Calcutt N. Tolerating diabetes: an alternative therapeutic approach for diabetic neuropathy. ASN Neuro. 2010 Sep 09; 2(4):e00042. PMID: 20842208; PMCID: PMC2936743.
    32. Davidson EP, Coppey LJ, Calcutt N, Oltman CL, Yorek MA. Diet-induced obesity in Sprague-Dawley rats causes microvascular and neural dysfunction. Diabetes Metab Res Rev. 2010 May; 26(4):306-18. PMID: 20503263; PMCID: PMC2878284.
    33. Davidson E, Coppey L, Lu B, Arballo V, Calcutt N, Gerard C, Yorek M. The roles of streptozotocin neurotoxicity and neutral endopeptidase in murine experimental diabetic neuropathy. Exp Diabetes Res. 2009; 2009:431980. PMID: 20148083; PMCID: PMC2817866.
    34. Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt N, Fernyhough P. Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes. 2010 Apr; 59(4):1082-91. PMID: 20103706; PMCID: PMC2844817.
    35. Fernyhough P, Calcutt N. Abnormal calcium homeostasis in peripheral neuropathies. Cell Calcium. 2010 Feb; 47(2):130-9. PMID: 20034667; PMCID: PMC2834846.
    36. Calcutt N, Lopez VL, Bautista AD, Mizisin LM, Torres BR, Shroads AL, Mizisin AP, Stacpoole PW. Peripheral neuropathy in rats exposed to dichloroacetate. J Neuropathol Exp Neurol. 2009 Sep; 68(9):985-93. PMID: 19680144; PMCID: PMC2741559.
    37. Malisza KL, Jones C, Gruwel ML, Foreman D, Fernyhough P, Calcutt N. Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. J Magn Reson Imaging. 2009 Aug; 30(2):271-6. PMID: 19629995; PMCID: PMC2742673.
    38. Calcutt N, Cooper ME, Kern TS, Schmidt AM. Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov. 2009 May; 8(5):417-29. PMID: 19404313.
      View in: PubMed
    39. Jolivalt CG, Mizisin LM, Nelson A, Cunha JM, Ramos KM, Bonke D, Calcutt N. B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol. 2009 Jun 10; 612(1-3):41-7. PMID: 19393643.
      View in: PubMed
    40. Garcia ML, Rao MV, Fujimoto J, Garcia VB, Shah SB, Crum J, Gotow T, Uchiyama Y, Ellisman M, Calcutt N, Cleveland DW. Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci. 2009 Feb 04; 29(5):1277-84. PMID: 19193875; PMCID: PMC2782950.
    41. Jolivalt CG, Lee CA, Ramos KM, Calcutt N. Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. Pain. 2008 Nov 15; 140(1):48-57. PMID: 18755547; PMCID: PMC2593464.
    42. Beiswenger KK, Calcutt N, Mizisin AP. Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice. Neurosci Lett. 2008 Sep 19; 442(3):267-72. PMID: 18619518; PMCID: PMC2610845.
    43. Cunha JM, Jolivalt CG, Ramos KM, Gregory JA, Calcutt N, Mizisin AP. Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors. Metabolism. 2008 Jul; 57(7):873-81. PMID: 18555826; PMCID: PMC2518323.
    44. Jolivalt CG, Vu Y, Mizisin LM, Mizisin AP, Calcutt N. Impaired prosaposin secretion during nerve regeneration in diabetic rats and protection of nerve regeneration by a prosaposin-derived peptide. J Neuropathol Exp Neurol. 2008 Jul; 67(7):702-10. PMID: 18596543; PMCID: PMC2748883.
    45. Beiswenger KK, Calcutt N, Mizisin AP. Epidermal nerve fiber quantification in the assessment of diabetic neuropathy. Acta Histochem. 2008; 110(5):351-62. PMID: 18384843; PMCID: PMC2561960.
    46. Burdo JR, Chen Q, Calcutt N, Schubert D. The pathological interaction between diabetes and presymptomatic Alzheimer's disease. Neurobiol Aging. 2009 Dec; 30(12):1910-7. PMID: 18372080.
      View in: PubMed
    47. Calcutt N, Jolivalt CG, Fernyhough P. Growth factors as therapeutics for diabetic neuropathy. Curr Drug Targets. 2008 Jan; 9(1):47-59. PMID: 18220712.
      View in: PubMed
    48. Calcutt N, Backonja MM. Pathogenesis of pain in peripheral diabetic neuropathy. Curr Diab Rep. 2007 Dec; 7(6):429-34. PMID: 18255005.
      View in: PubMed
    49. Landgraf RR, Garrett TJ, Calcutt N, Stacpoole PW, Yost RA. MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue. Anal Chem. 2007 Nov 01; 79(21):8170-5. PMID: 17894472.
      View in: PubMed
    50. Jolivalt CG, Dacunha JM, Esch FS, Calcutt N. Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. Eur J Pain. 2008 Jan; 12(1):76-81. PMID: 17466547.
      View in: PubMed
    51. Ramos KM, Jiang Y, Svensson CI, Calcutt N. Pathogenesis of spinally mediated hyperalgesia in diabetes. Diabetes. 2007 Jun; 56(6):1569-76. PMID: 17287466.
      View in: PubMed
    52. Jiang Y, Calcutt N, Ramos KM, Rames KM, Mizisin AP. Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic rats. J Peripher Nerv Syst. 2006 Dec; 11(4):274-85. PMID: 17117935.
      View in: PubMed
    53. Malmberg AB, O'Connor WT, Glennon JC, Ceseña R, Calcutt N. Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats. Brain Res. 2006 Oct 18; 1115(1):48-53. PMID: 16920081.
      View in: PubMed
    54. Calcutt N, Freshwater JD, Hauptmann N, Taylor EM, Mizisin AP. Protection of sensory function in diabetic rats by Neotrofin. Eur J Pharmacol. 2006 Mar 18; 534(1-3):187-93. PMID: 16507305.
      View in: PubMed
    55. Jolivalt CG, Ramos KM, Herbetsson K, Esch FS, Calcutt N. Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia. Pain. 2006 Mar; 121(1-2):14-21. PMID: 16480831.
      View in: PubMed
    56. Malmberg AB, Mizisin AP, Calcutt N, von Stein T, Robbins WR, Bley KR. Reduced heat sensitivity and epidermal nerve fiber immunostaining following single applications of a high-concentration capsaicin patch. Pain. 2004 Oct; 111(3):360-7. PMID: 15363880.
      View in: PubMed
    57. Mizisin AP, Vu Y, Shuff M, Calcutt N. Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats. Diabetes. 2004 Jul; 53(7):1807-12. PMID: 15220205.
      View in: PubMed
    58. Calcutt N. Experimental models of painful diabetic neuropathy. J Neurol Sci. 2004 May 15; 220(1-2):137-9. PMID: 15140623.
      View in: PubMed
    59. Calcutt N, Freshwater JD, Mizisin AP. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr; 47(4):718-24. PMID: 15298349.
      View in: PubMed
    60. Calcutt N. Modeling diabetic sensory neuropathy in rats. Methods Mol Med. 2004; 99:55-65. PMID: 15131329.
      View in: PubMed
    61. Garcia ML, Lobsiger CS, Shah SB, Deerinck TJ, Crum J, Young D, Ward CM, Crawford TO, Gotow T, Uchiyama Y, Ellisman MH, Calcutt N, Cleveland DW. NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol. 2003 Dec 08; 163(5):1011-20. PMID: 14662745; PMCID: PMC2173620.
    62. Svensson CI, Marsala M, Westerlund A, Calcutt N, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TL. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 2003 Sep; 86(6):1534-44. PMID: 12950462.
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    63. Sayers NM, Beswick LJ, Middlemas A, Calcutt N, Mizisin AP, Tomlinson DR, Fernyhough P. Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats. Diabetes. 2003 Sep; 52(9):2372-80. PMID: 12941778.
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    64. Huang TJ, Price SA, Chilton L, Calcutt N, Tomlinson DR, Verkhratsky A, Fernyhough P. Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes. 2003 Aug; 52(8):2129-36. PMID: 12882932.
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    65. Calcutt N, Allendoerfer KL, Mizisin AP, Middlemas A, Freshwater JD, Burgers M, Ranciato R, Delcroix JD, Taylor FR, Shapiro R, Strauch K, Dudek H, Engber TM, Galdes A, Rubin LL, Tomlinson DR. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest. 2003 Feb; 111(4):507-14. PMID: 12588889; PMCID: PMC151919.
    66. Calcutt N. Future treatments for diabetic neuropathy: clues from experimental neuropathy. Curr Diab Rep. 2002 Dec; 2(6):482-8. PMID: 12643154.
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    67. Rao MV, Garcia ML, Miyazaki Y, Gotow T, Yuan A, Mattina S, Ward CM, Calcutt N, Uchiyama Y, Nixon RA, Cleveland DW. Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol. 2002 Aug 19; 158(4):681-93. PMID: 12186852.
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    68. Freshwater JD, Svensson CI, Malmberg AB, Calcutt N. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Diabetes. 2002 Jul; 51(7):2249-55. PMID: 12086957.
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    69. Calcutt N. Potential mechanisms of neuropathic pain in diabetes. Int Rev Neurobiol. 2002; 50:205-28. PMID: 12198811.
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    70. Calcutt N, Freshwater JD, O'Brien JS. Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiology. 2000 Nov; 93(5):1271-8. PMID: 11046216.
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    71. Calcutt N, Stiller C, Gustafsson H, Malmberg AB. Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats. Brain Res. 2000 Feb 21; 856(1-2):20-7. PMID: 10677607.
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    72. Calcutt N, Chen P, Hua XY. Effects of diabetes on tissue content and evoked release of calcitonin gene-related peptide-like immunoreactivity from rat sensory nerves. Neurosci Lett. 1998 Oct 02; 254(3):129-32. PMID: 10214974.
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