Charles Mosier

Title(s)	Staff Res Assoc, School of Pharmacy and Pharmaceutical Science
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracell Vesicles Circ Nucl Acids. 2023; 4(4):588-598. Hook V, Podvin S, Mosier C, Boyarko B, Seyffert L, Stringer H, Rissman RA. PMID: 38125374; PMCID: PMC10732590.

View in: PubMed Mentions:
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. 2023 08 01; 62(15):2289-2300. Yoon MC, Phan V, Podvin S, Mosier C, O'Donoghue AJ, Hook V. PMID: 37459182; PMCID: PMC10399199.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells
Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems. J Huntingtons Dis. 2023; 12(4):315-333. Podvin S, Mosier C, Poon W, Wei E, Rossitto LA, Hook V. PMID: 38108356.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Humans
Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions. ACS Omega. 2022 Jul 26; 7(29):25346-25352. Phan VV, Mosier C, Yoon MC, Glukhov E, Caffrey CR, O'Donoghue AJ, Gerwick WH, Hook V. PMID: 35910167; PMCID: PMC9330179.

View in: PubMed Mentions:
Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases. ACS Chem Neurosci. 2022 01 19; 13(2):245-256. Yoon MC, Ames J, Mosier C, Jiang Z, Podvin S, O'Donoghue AJ, Hook V. PMID: 34986304; PMCID: PMC9070308.

View in: PubMed Mentions: 1 Fields:
Neu Neurology
Translation:Cells
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chem Biol. 2021 09 17; 16(9):1628-1643. Yoon MC, Solania A, Jiang Z, Christy MP, Podvin S, Mosier C, Lietz CB, Ito G, Gerwick WH, Wolan DW, Hook G, O'Donoghue AJ, Hook V. PMID: 34416110; PMCID: PMC9104225.

View in: PubMed Mentions: 20 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Cells
Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega. 2021 May 25; 6(20):13033-13056. Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. PMID: 34056454; PMCID: PMC8158845.

View in: PubMed Mentions: 8
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689; PMCID: PMC7261628.

View in: PubMed Mentions: 47 Fields:
Bio Biochemistry Bio Biophysics Mol Molecular Biology
Translation:Humans Animals Cells
Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. J Neurol. 2019 Mar; 266(3):551-564. Podvin S, Reardon HT, Yin K, Mosier C, Hook V. PMID: 29956026.

View in: PubMed Mentions: 19 Fields:
Neu Neurology
Translation:Humans Cells
Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. J Am Soc Mass Spectrom. 2018 05; 29(5):935-947. Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. PMID: 29556927; PMCID: PMC5943185.

View in: PubMed Mentions: 9 Fields:
Che Chemistry Techniques
Translation:Animals Cells
Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides. 2013 Aug; 46:126-35. Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V. PMID: 23747840; PMCID: PMC3842158.

View in: PubMed Mentions: 18 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters. J Biol Chem. 2012 May 04; 287(19):15232-41. Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. PMID: 22393040; PMCID: PMC3346103.

View in: PubMed Mentions: 19 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24. Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. PMID: 20695487; PMCID: PMC2996463.

View in: PubMed Mentions: 32 Fields:
Bio Biochemistry
Translation:Animals Cells
Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin. Endocrine. 2009 Jun; 35(3):429-37. Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. PMID: 19343278; PMCID: PMC2731682.

View in: PubMed Mentions: 11 Fields:
End Endocrinology
Translation:Humans
Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression. J Biol Chem. 2008 Dec 19; 283(51):35652-9. Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. PMID: 18849346; PMCID: PMC2602888.

View in: PubMed Mentions: 34 Fields:
Bio Biochemistry
Translation:Animals Cells
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion. J Biol Chem. 2007 Mar 30; 282(13):9556-9563. Hwang SR, Garza C, Mosier C, Toneff T, Wunderlich E, Goldsmith P, Hook V. PMID: 17244622.

View in: PubMed Mentions: 27 Fields:
Bio Biochemistry
Translation:Animals Cells