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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chem Biol. 2021 Aug 20.
Yoon MC, Solania A, Jiang Z, Christy MP, Podvin S, Mosier C, Lietz CB, Ito G, Gerwick WH, Wolan DW, Hook G, O'Donoghue AJ, Hook V. PMID: 34416110.
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Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega. 2021 May 25; 6(20):13033-13056.
Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. PMID: 34056454.
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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428.
Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689.
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6 Fields:
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HumansAnimalsCells
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Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. J Neurol. 2019 Mar; 266(3):551-564.
Podvin S, Reardon HT, Yin K, Mosier C, Hook V. PMID: 29956026.
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8 Fields:
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HumansCells
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Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. J Am Soc Mass Spectrom. 2018 05; 29(5):935-947.
Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. PMID: 29556927.
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5 Fields:
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AnimalsCells
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Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides. 2013 Aug; 46:126-35.
Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V. PMID: 23747840.
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14 Fields:
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HumansAnimalsCells
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Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters. J Biol Chem. 2012 May 04; 287(19):15232-41.
Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. PMID: 22393040.
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13 Fields:
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HumansAnimalsCells
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Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24.
Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. PMID: 20695487.
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24 Fields:
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Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin. Endocrine. 2009 Jun; 35(3):429-37.
Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. PMID: 19343278.
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10 Fields:
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Humans
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Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression. J Biol Chem. 2008 Dec 19; 283(51):35652-9.
Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. PMID: 18849346.
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32 Fields:
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AnimalsCells
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Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion. J Biol Chem. 2007 Mar 30; 282(13):9556-9563.
Hwang SR, Garza C, Mosier C, Toneff T, Wunderlich E, Goldsmith P, Hook V. PMID: 17244622.
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26 Fields:
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AnimalsCells