Jerel Fields
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Title(s) | Assistant Adjunct Professor, Psychiatry |
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School | Health Sciences |
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Address | 9500 Gilman Drive #0603 La Jolla CA 92093
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vCard | Download vCard |
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Biography University of North Texas, Denton, TX | BS | 05/2004 | Biology | University of Texas at San Antonio, San Antonio, TX | MS | 05/2007 | Biology | University of North Texas Health Science Center, Fort Worth, TX | PhD | 05/2012 | Biomedical Sciences | University of California, San Diego, San Diego, CA | Postdoc | 03/2017 | Experimental Neuropathology |
Overview Our research is focused on understanding and developing therapies for neurodegenerative diseases. We are particularly interested in how alterations in mitochondrial function and chronic inflammation interact in the neurodegenerative process. Our work includes examining postmortem brain specimens from humans and animal models to identify neuropathological signatures associated with disease. We use in vitro models to dissect neuropathogenic mechanisms and test therapeutic strategies in neurons, astrocytes, and microglia. Ultimately, the goal of our work is to identify therapeutic targets and treatments that will improve clinical outcomes for people suffering from neurological disorders.
Research Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders. AIDS. 2021 Mar 01; 35(3):429-437.
PMID: 33252483.
View in: PubMed Mentions: Fields:
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Effects of innate immune receptor stimulation on extracellular a-synuclein uptake and degradation by brain resident cells. Exp Mol Med. 2021 Feb 16.
PMID: 33594256.
View in: PubMed Mentions: Fields:
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Antiretroviral drug concentrations in brain tissue of adult decedents. AIDS. 2020 11 01; 34(13):1907-1914.
Ferrara M, Bumpus NN, Ma Q, Ellis RJ, Soontornniyomkij V, Fields JA, Bharti A, Achim CL, Moore DJ, Letendre SL. PMID: 32694413.
View in: PubMed Mentions: 1 Fields:
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Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV. Neurol Neuroimmunol Neuroinflamm. 2020 11 05; 7(6).
Ellis RJ, Moore DJ, Sundermann EE, Heaton RK, Mehta S, Hulgan T, Samuels D, Fields JA, Letendre SL. PMID: 33055205.
View in: PubMed Mentions: Fields:
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Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior. J Neuroimmune Pharmacol. 2020 12; 15(4):743-764.
Saloner R, Fields JA, Marcondes MCG, Iudicello JE, von Känel S, Cherner M, Letendre SL, Kaul M, Grant I. PMID: 32929575.
View in: PubMed Mentions: Fields:
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Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV. Ann Clin Transl Neurol. 2020 07; 7(7):1166-1173.
Ellis RJ, Diaz M, Sacktor N, Marra C, Collier AC, Clifford DB, Calcutt N, Fields JA, Heaton RK, Letendre SL. PMID: 32619341.
View in: PubMed Mentions: Fields:
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Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection. Brain Behav Immun. 2020 10; 89:184-199.
Ojeda-Juárez D, Shah R, Fields JA, Harahap-Carrillo IS, Koury J, Maung R, Gelman BB, Baaten BJ, Roberts AJ, Kaul M. PMID: 32534984.
View in: PubMed Mentions: 2 Fields:
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Beta amyloid levels in cerebrospinal fluid of HIV-infected people vary by exposure to antiretroviral therapy. AIDS. 2020 06 01; 34(7):1001-1007.
Fields JA, Swinton MK, Soontornniyomkij B, Carson A, Achim CL. PMID: 32073451.
View in: PubMed Mentions: 1 Fields:
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Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein ß in HIV-associated neurocognitive disorder. J Neuroinflammation. 2020 Apr 11; 17(1):112.
Canchi S, Swinton MK, Rissman RA, Fields JA. PMID: 32276639.
View in: PubMed Mentions: Fields:
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Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice. Sci Rep. 2019 11 20; 9(1):17158.
Fields JA, Swinton MK, Carson A, Soontornniyomkij B, Lindsay C, Han MM, Frizzi K, Sambhwani S, Murphy A, Achim CL, Ellis RJ, Calcutt NA. PMID: 31748578.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia. Neurobiol Dis. 2019 10; 130:104502.
Swinton MK, Carson A, Telese F, Sanchez AB, Soontornniyomkij B, Rad L, Batki I, Quintanilla B, Pérez-Santiago J, Achim CL, Letendre S, Ellis RJ, Grant I, Murphy AN, Fields JA. PMID: 31238091.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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HIV in the cART era and the mitochondrial: immune interface in the CNS. Int Rev Neurobiol. 2019; 145:29-65.
Fields JA, Ellis RJ. PMID: 31208526.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Alterations in brain TREM2 and Amyloid-ß levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem. 2018 12; 147(6):784-802.
Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. PMID: 30152135.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating a-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018 08 09; 13(1):43.
Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E. PMID: 30092810.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimals
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Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice. Behav Brain Res. 2018 09 03; 349:73-79.
PMID: 29709610.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Human immunodeficiency virus Tat impairs mitochondrial fission in neurons. Cell Death Discov. 2018 Dec; 4:8.
Rozzi SJ, Avdoshina V, Fields JA, Mocchetti I. PMID: 29531805.
View in: PubMed Mentions:
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Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol. 2018 04; 24(2):156-167.
PMID: 29075998.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Human Immunodeficiency Virus Promotes Mitochondrial Toxicity. Neurotox Res. 2017 Nov; 32(4):723-733.
PMID: 28695547.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimalsCells
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Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105.
PMID: 28254829.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
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HIV Tat protein and amyloid-ß peptide form multifibrillar structures that cause neurotoxicity. Nat Struct Mol Biol. 2017 04; 24(4):379-386.
Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, Lee MH, Dickens AM, Haughey N, Dimitriadis EK, Nath A. PMID: 28218748.
View in: PubMed Mentions: 22 Fields: Translation: HumansAnimalsCells
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The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303.
PMID: 28105557.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 01 05; 5(1):2.
PMID: 28057080.
View in: PubMed Mentions: 15 Fields: Translation: HumansAnimalsCells
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Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120.
PMID: 27220536.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotox Res. 2016 May; 29(4):583-593.
PMID: 26936603.
View in: PubMed Mentions: 32 Fields: Translation: HumansAnimalsCells
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HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69.
PMID: 26611103.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimalsCells
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HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci. 2015 Feb 04; 35(5):1921-38.
PMID: 25653352.
View in: PubMed Mentions: 53 Fields: Translation: AnimalsCells
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Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015; 13(1):43-54.
PMID: 25760044.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimalsCells
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Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on a-synuclein. Neuron. 2015 Jan 07; 85(1):76-87.
PMID: 25533483.
View in: PubMed Mentions: 51 Fields: Translation: Animals
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Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94.
PMID: 24509835.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders. J Neuroimmune Pharmacol. 2014 Mar; 9(2):102-16.
PMID: 24510686.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimals
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Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2013 Dec; 8(5):1197-209.
PMID: 24292993.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1ß-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression. PLoS One. 2013; 8(2):e56891.
Fields J, Cisneros IE, Borgmann K, Ghorpade A. PMID: 23457635.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol. 2013 Feb; 19(1):89-101.
PMID: 23341224.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimals
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C/EBPß regulates multiple IL-1ß-induced human astrocyte inflammatory genes. J Neuroinflammation. 2012 Jul 20; 9:177.
PMID: 22818222.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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CCAAT/enhancer binding protein ß expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1. J Neurochem. 2011 Jul; 118(1):93-104.
Fields J, Gardner-Mercer J, Borgmann K, Clark I, Ghorpade A. PMID: 21281310.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Translationally regulated C/EBP beta isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells. Prostate. 2008 Sep 01; 68(12):1362-71.
Kim MH, Fields J, Field J. PMID: 18512730.
View in: PubMed Mentions: 11 Fields: Translation: HumansCells
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Year | Publications |
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2008 | 1 | 2011 | 1 | 2012 | 1 | 2013 | 3 | 2014 | 3 | 2015 | 3 | 2016 | 2 | 2017 | 6 | 2018 | 4 | 2019 | 3 | 2020 | 7 | 2021 | 2 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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