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Jerel Fields

TitleAssistant Adjunct Professor
InstitutionUniversity of California San Diego
DepartmentPsychiatry
Address9500 Gilman Drive #0603
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Mitochondrial biogenesis dysfunction in the CNS of HIV-infected individuals on antiretroviral therapy
    NIH/NIMH K01MH115819Feb 1, 2018 - Jan 31, 2021
    Role: Principal Investigator
    Development of Pirenzepine for HIV-SN
    NIH/NINDS R41NS105177Sep 28, 2017 - Aug 31, 2018
    Role: Co-Principal Investigator
    Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associated
    NIH/NINDS F32NS083426Apr 1, 2013 - Mar 31, 2015
    Role: Principal Investigator
    Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia
    NIH/NINDS F31NS072006Apr 1, 2011 - Mar 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. Alterations in brain TREM2 and Amyloid-ß levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem. 2018 Aug 27. PMID: 30152135.
      View in: PubMed
    2. Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating a-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018 Aug 09; 13(1):43. PMID: 30092810.
      View in: PubMed
    3. Kesby JP, Fields JA, Chang A, Coban H, Achim CL, Semenova S. Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice. Behav Brain Res. 2018 Apr 27; 349:73-79. PMID: 29709610.
      View in: PubMed
    4. Rozzi SJ, Avdoshina V, Fields JA, Mocchetti I. Human immunodeficiency virus Tat impairs mitochondrial fission in neurons. Cell Death Discov. 2018 Dec; 4:8. PMID: 29531805.
      View in: PubMed
    5. Thaney VE, Sanchez AB, Fields JA, Minassian A, Young JW, Maung R, Kaul M. Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol. 2018 Apr; 24(2):156-167. PMID: 29075998.
      View in: PubMed
    6. Rozzi SJ, Avdoshina V, Fields JA, Trejo M, Ton HT, Ahern GP, Mocchetti I. Human Immunodeficiency Virus Promotes Mitochondrial Toxicity. Neurotox Res. 2017 Nov; 32(4):723-733. PMID: 28695547.
      View in: PubMed
    7. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. PMID: 28254829.
      View in: PubMed
    8. Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. PMID: 28105557.
      View in: PubMed
    9. Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 01 05; 5(1):2. PMID: 28057080.
      View in: PubMed
    10. Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120. PMID: 27220536.
      View in: PubMed
    11. Avdoshina V, Fields JA, Castellano P, Dedoni S, Palchik G, Trejo M, Adame A, Rockenstein E, Eugenin E, Masliah E, Mocchetti I. The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotox Res. 2016 May; 29(4):583-593. PMID: 26936603.
      View in: PubMed
    12. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. PMID: 26611103; PMCID: PMC4713337.
      View in: PubMed, PubMed Central
    13. Fields J, Dumaop W, Eleuteri S, Elueteri S, Campos S, Serger E, Trejo M, Kosberg K, Adame A, Spencer B, Rockenstein E, He JJ, Masliah E. HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci. 2015 Feb 04; 35(5):1921-38. PMID: 25653352; PMCID: PMC4315828.
      View in: PubMed, PubMed Central
    14. Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015; 13(1):43-54. PMID: 25760044; PMCID: PMC4455959.
      View in: PubMed, PubMed Central
    15. Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on a-synuclein. Neuron. 2015 Jan 07; 85(1):76-87. PMID: 25533483.
      View in: PubMed
    16. Fields J, Dumaop W, Langford TD, Rockenstein E, Masliah E. Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders. J Neuroimmune Pharmacol. 2014 Mar; 9(2):102-16. PMID: 24510686; PMCID: PMC3973421.
      View in: PubMed, PubMed Central
    17. Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. PMID: 24509835; PMCID: PMC4324760.
      View in: PubMed, PubMed Central
    18. Fields J, Dumaop W, Adame A, Ellis RJ, Letendre S, Grant I, Masliah E. Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2013 Dec; 8(5):1197-209. PMID: 24292993; PMCID: PMC3973444.
      View in: PubMed, PubMed Central
    19. Fields J, Dumaop W, Rockenstein E, Mante M, Spencer B, Grant I, Ellis R, Letendre S, Patrick C, Adame A, Masliah E. Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol. 2013 Feb; 19(1):89-101. PMID: 23341224; PMCID: PMC3567331.
      View in: PubMed, PubMed Central
    20. Fields J, Ghorpade A. C/EBPß regulates multiple IL-1ß-induced human astrocyte inflammatory genes. J Neuroinflammation. 2012 Jul 20; 9:177. PMID: 22818222; PMCID: PMC3464795.
      View in: PubMed, PubMed Central
    21. Fields J, Gardner-Mercer J, Borgmann K, Clark I, Ghorpade A. CCAAT/enhancer binding protein ß expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1. J Neurochem. 2011 Jul; 118(1):93-104. PMID: 21281310; PMCID: PMC3112278.
      View in: PubMed, PubMed Central
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