Jerel Fields

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of North Texas, Denton, TXBS05/2004Biology
    University of Texas at San Antonio, San Antonio, TXMS05/2007Biology
    University of North Texas Health Science Center, Fort Worth, TXPhD05/2012Biomedical Sciences
    University of California, San Diego, San Diego, CAPostdoc03/2017Experimental Neuropathology

    Collapse Overview 
    Collapse Overview
    Our research is focused on understanding and developing therapies for neurodegenerative diseases. We are particularly interested in how alterations in mitochondrial function and chronic inflammation interact in the neurodegenerative process. Our work includes examining postmortem brain specimens from humans and animal models to identify neuropathological signatures associated with disease. We use in vitro models to dissect neuropathogenic mechanisms and test therapeutic strategies in neurons, astrocytes, and microglia. Ultimately, the goal of our work is to identify therapeutic targets and treatments that will improve clinical outcomes for people suffering from neurological disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    The role of TREM2 in Alzheimer's disease neuropathogenesis in HIV+ individuals
    NIH R56AG066215Sep 15, 2020 - Aug 31, 2021
    Role: Principal Investigator
    Mitochondrial biogenesis dysfunction in the CNS of HIV-infected individuals on antiretroviral therapy
    NIH K01MH115819Feb 1, 2018 - Jan 31, 2021
    Role: Principal Investigator
    Development of Pirenzepine for HIV-SN
    NIH R41NS105177Sep 28, 2017 - Aug 31, 2019
    Role: Co-Principal Investigator
    Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associated
    NIH F32NS083426Apr 1, 2013 - Mar 31, 2015
    Role: Principal Investigator
    Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia
    NIH F31NS072006Apr 1, 2011 - Mar 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Caloric Restriction Mimetic 2-Deoxyglucose Reduces Inflammatory Signaling in Human Astrocytes: Implications for Therapeutic Strategies Targeting Neurodegenerative Diseases. Brain Sci. 2022 Feb 24; 12(3). Vallee KJ, Fields JA. PMID: 35326266; PMCID: PMC8945872.
      View in: PubMed   Mentions:
    2. Higher buccal mitochondrial DNA and mitochondrial common deletion number are associated with markers of neurodegeneration and inflammation in cerebrospinal fluid. J Neurovirol. 2022 04; 28(2):281-290. Solanky D, Fields JA, Iudicello JE, Ellis RJ, Franklin D, Clifford DB, Gelman BB, Marra CM, Morgello S, Rubin LH, Grant I, Heaton RK, Letendre SL, Mehta SR. PMID: 35157246; PMCID: PMC9352370.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Editorial: Advances in Understanding NeuroHIV Associated Changes in Neuroimmune Communication in the Combined Anti-retroviral Therapy (cART) Era. Front Neurol. 2021; 12:763448. Gaskill PJ, Fields JA, Langford DT, Stauch KL, Williams DW. PMID: 34675877; PMCID: PMC8523985.
      View in: PubMed   Mentions:
    4. Alterations in Brain Cannabinoid Receptor Levels Are Associated with HIV-Associated Neurocognitive Disorders in the ART Era: Implications for Therapeutic Strategies Targeting the Endocannabinoid System. Viruses. 2021 08 31; 13(9). Swinton MK, Sundermann EE, Pedersen L, Nguyen JD, Grelotti DJ, Taffe MA, Iudicello JE, Fields JA. PMID: 34578323; PMCID: PMC8473156.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine. Front Neurol. 2021; 12:663373. Han MM, Frizzi KE, Ellis RJ, Calcutt NA, Fields JA. PMID: 34211430; PMCID: PMC8239242.
      View in: PubMed   Mentions: 2  
    6. The utility of olfactory function in distinguishing early-stage Alzheimer's disease from HIV-associated neurocognitive disorders. AIDS. 2021 03 01; 35(3):429-437. Sundermann EE, Fields A, Saloner R, Gouaux B, Bharti A, Murphy C, Moore DJ. PMID: 33252483; PMCID: PMC7856221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells. Exp Mol Med. 2021 02; 53(2):281-290. Kim C, Kwon S, Iba M, Spencer B, Rockenstein E, Mante M, Adame A, Shin SJ, Fields JA, Rissman RA, Lee SJ, Masliah E. PMID: 33594256; PMCID: PMC8080790.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    8. The Cannabinoid Receptor Agonist, WIN-55212-2, Suppresses the Activation of Proinflammatory Genes Induced by Interleukin 1 Beta in Human Astrocytes. Cannabis Cannabinoid Res. 2022 02; 7(1):78-92. Fields JA, Swinton MK, Montilla-Perez P, Ricciardelli E, Telese F. PMID: 33998879; PMCID: PMC8864424.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Antiretroviral drug concentrations in brain tissue of adult decedents. AIDS. 2020 11 01; 34(13):1907-1914. Ferrara M, Bumpus NN, Ma Q, Ellis RJ, Soontornniyomkij V, Fields JA, Bharti A, Achim CL, Moore DJ, Letendre SL. PMID: 32694413.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    10. Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV. Neurol Neuroimmunol Neuroinflamm. 2020 11 05; 7(6). Ellis RJ, Moore DJ, Sundermann EE, Heaton RK, Mehta S, Hulgan T, Samuels D, Fields JA, Letendre SL. PMID: 33055205; PMCID: PMC7577534.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior. J Neuroimmune Pharmacol. 2020 12; 15(4):743-764. Saloner R, Fields JA, Marcondes MCG, Iudicello JE, von Känel S, Cherner M, Letendre SL, Kaul M, Grant I, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 32929575; PMCID: PMC7719083.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    12. Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV. Ann Clin Transl Neurol. 2020 07; 7(7):1166-1173. Ellis RJ, Diaz M, Sacktor N, Marra C, Collier AC, Clifford DB, Calcutt N, Fields JA, Heaton RK, Letendre SL, CNS Antiretroviral Therapy Effects Research (CHARTER) Study Group. PMID: 32619341; PMCID: PMC7359117.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection. Brain Behav Immun. 2020 10; 89:184-199. Ojeda-Juárez D, Shah R, Fields JA, Harahap-Carrillo IS, Koury J, Maung R, Gelman BB, Baaten BJ, Roberts AJ, Kaul M. PMID: 32534984; PMCID: PMC8153086.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Beta amyloid levels in cerebrospinal fluid of HIV-infected people vary by exposure to antiretroviral therapy. AIDS. 2020 06 01; 34(7):1001-1007. Fields JA, Swinton MK, Soontornniyomkij B, Carson A, Achim CL. PMID: 32073451; PMCID: PMC7210049.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disorder. J Neuroinflammation. 2020 Apr 11; 17(1):112. Canchi S, Swinton MK, Rissman RA, Fields JA. PMID: 32276639; PMCID: PMC7149918.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice. Sci Rep. 2019 11 20; 9(1):17158. Fields JA, Swinton MK, Carson A, Soontornniyomkij B, Lindsay C, Han MM, Frizzi K, Sambhwani S, Murphy A, Achim CL, Ellis RJ, Calcutt NA. PMID: 31748578; PMCID: PMC6868155.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia. Neurobiol Dis. 2019 10; 130:104502. Swinton MK, Carson A, Telese F, Sanchez AB, Soontornniyomkij B, Rad L, Batki I, Quintanilla B, Pérez-Santiago J, Achim CL, Letendre S, Ellis RJ, Grant I, Murphy AN, Fields JA. PMID: 31238091; PMCID: PMC6714553.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    18. HIV in the cART era and the mitochondrial: immune interface in the CNS. Int Rev Neurobiol. 2019; 145:29-65. Fields JA, Ellis RJ. PMID: 31208526.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    19. Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem. 2018 12; 147(6):784-802. Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. PMID: 30152135; PMCID: PMC6310632.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018 08 09; 13(1):43. Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E. PMID: 30092810; PMCID: PMC6085656.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    21. Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice. Behav Brain Res. 2018 09 03; 349:73-79. Kesby JP, Fields JA, Chang A, Coban H, Achim CL, Semenova S, TMARC Group. PMID: 29709610; PMCID: PMC6320247.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Human immunodeficiency virus Tat impairs mitochondrial fission in neurons. Cell Death Discov. 2018 Dec; 4:8. Rozzi SJ, Avdoshina V, Fields JA, Mocchetti I. PMID: 29531805; PMCID: PMC5841280.
      View in: PubMed   Mentions: 25  
    23. Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol. 2018 04; 24(2):156-167. Thaney VE, Sanchez AB, Fields JA, Minassian A, Young JW, Maung R, Kaul M. PMID: 29075998; PMCID: PMC5911244.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    24. Human Immunodeficiency Virus Promotes Mitochondrial Toxicity. Neurotox Res. 2017 Nov; 32(4):723-733. Rozzi SJ, Avdoshina V, Fields JA, Trejo M, Ton HT, Ahern GP, Mocchetti I. PMID: 28695547; PMCID: PMC5711529.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    25. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. PMID: 28254829; PMCID: PMC5379957.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    26. HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity. Nat Struct Mol Biol. 2017 04; 24(4):379-386. Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, Lee MH, Dickens AM, Haughey N, Dimitriadis EK, Nath A. PMID: 28218748; PMCID: PMC5383535.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    27. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. PMID: 28105557; PMCID: PMC5729903.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 01 05; 5(1):2. Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. PMID: 28057080; PMCID: PMC5217191.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120. Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. PMID: 27220536; PMCID: PMC4879748.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    30. The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotox Res. 2016 May; 29(4):583-593. Avdoshina V, Fields JA, Castellano P, Dedoni S, Palchik G, Trejo M, Adame A, Rockenstein E, Eugenin E, Masliah E, Mocchetti I. PMID: 26936603; PMCID: PMC4821687.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    31. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. PMID: 26611103; PMCID: PMC4713337.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    32. HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci. 2015 Feb 04; 35(5):1921-38. Fields J, Dumaop W, Eleuteri S, Elueteri S, Campos S, Serger E, Trejo M, Kosberg K, Adame A, Spencer B, Rockenstein E, He JJ, Masliah E. PMID: 25653352; PMCID: PMC4315828.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    33. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015; 13(1):43-54. Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. PMID: 25760044; PMCID: PMC4455959.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    34. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 2015 Jan 07; 85(1):76-87. Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. PMID: 25533483; PMCID: PMC4289081.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    35. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. PMID: 24509835; PMCID: PMC4324760.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    36. Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders. J Neuroimmune Pharmacol. 2014 Mar; 9(2):102-16. Fields J, Dumaop W, Langford TD, Rockenstein E, Masliah E. PMID: 24510686; PMCID: PMC3973421.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    37. Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2013 Dec; 8(5):1197-209. Fields J, Dumaop W, Adame A, Ellis RJ, Letendre S, Grant I, Masliah E. PMID: 24292993; PMCID: PMC3973444.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    38. Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1β-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression. PLoS One. 2013; 8(2):e56891. Fields J, Cisneros IE, Borgmann K, Ghorpade A. PMID: 23457635; PMCID: PMC3572966.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    39. Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol. 2013 Feb; 19(1):89-101. Fields J, Dumaop W, Rockenstein E, Mante M, Spencer B, Grant I, Ellis R, Letendre S, Patrick C, Adame A, Masliah E. PMID: 23341224; PMCID: PMC3567331.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    40. C/EBPβ regulates multiple IL-1β-induced human astrocyte inflammatory genes. J Neuroinflammation. 2012 Jul 20; 9:177. Fields J, Ghorpade A. PMID: 22818222; PMCID: PMC3464795.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    41. CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1. J Neurochem. 2011 Jul; 118(1):93-104. Fields J, Gardner-Mercer J, Borgmann K, Clark I, Ghorpade A. PMID: 21281310; PMCID: PMC3112278.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    42. Translationally regulated C/EBP beta isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells. Prostate. 2008 Sep 01; 68(12):1362-71. Kim MH, Fields J, Field J. PMID: 18512730.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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