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    Jerel Fields

    TitleAssistant Researcher
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0624
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Mitochondrial biogenesis dysfunction in the CNS of HIV-infected individuals on antiretroviral therapy
      NIH/NIMH K01MH115819Feb 1, 2018 - Jan 31, 2021
      Role: Principal Investigator
      Development of Pirenzepine for HIV-SN
      NIH/NINDS R41NS105177Sep 28, 2017 - Aug 31, 2018
      Role: Co-Principal Investigator
      Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associated
      NIH/NINDS F32NS083426Apr 1, 2013 - Mar 31, 2015
      Role: Principal Investigator
      Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia
      NIH/NINDS F31NS072006Apr 1, 2011 - Mar 31, 2012
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rozzi SJ, Avdoshina V, Fields J, Trejo M, Ton HT, Ahern GP, Mocchetti I. Human Immunodeficiency Virus Promotes Mitochondrial Toxicity. Neurotox Res. 2017 Jul 10. PMID: 28695547.
        View in: PubMed
      2. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields J, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. PMID: 28254829.
        View in: PubMed
      3. Fields J, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 Apr; 23(2):290-303. PMID: 28105557.
        View in: PubMed
      4. Valera E, Spencer B, Fields J, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 Jan 05; 5(1):2. PMID: 28057080.
        View in: PubMed
      5. Fields J, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016; 13(1):120. PMID: 27220536.
        View in: PubMed
      6. Avdoshina V, Fields J, Castellano P, Dedoni S, Palchik G, Trejo M, Adame A, Rockenstein E, Eugenin E, Masliah E, Mocchetti I. The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotox Res. 2016 May; 29(4):583-93. PMID: 26936603.
        View in: PubMed
      7. Fields J, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. PMID: 26611103; PMCID: PMC4713337.
      8. Fields J, Dumaop W, Elueteri S, Campos S, Serger E, Trejo M, Kosberg K, Adame A, Spencer B, Rockenstein E, He JJ, Masliah E. HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders. J Neurosci. 2015 Feb 4; 35(5):1921-38. PMID: 25653352.
        View in: PubMed
      9. Fields J, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015; 13(1):43-54. PMID: 25760044; PMCID: PMC4455959.
      10. Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields J, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on a-synuclein. Neuron. 2015 Jan 07; 85(1):76-87. PMID: 25533483; PMCID: PMC4289081.
      11. Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. PMID: 24509835; PMCID: PMC4324760.
      12. Fields J, Dumaop W, Langford TD, Rockenstein E, Masliah E. Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders. J Neuroimmune Pharmacol. 2014 Mar; 9(2):102-16. PMID: 24510686; PMCID: PMC3973421.
      13. Fields J, Dumaop W, Adame A, Ellis RJ, Letendre S, Grant I, Masliah E. Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2013 Dec; 8(5):1197-209. PMID: 24292993; PMCID: PMC3973444.
      14. Fields J, Dumaop W, Rockenstein E, Mante M, Spencer B, Grant I, Ellis R, Letendre S, Patrick C, Adame A, Masliah E. Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol. 2013 Feb; 19(1):89-101. PMID: 23341224; PMCID: PMC3567331.
      15. Fields J, Ghorpade A. C/EBPß regulates multiple IL-1ß-induced human astrocyte inflammatory genes. J Neuroinflammation. 2012; 9:177. PMID: 22818222; PMCID: PMC3464795.