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Jerel Fields

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolHealth Sciences
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    Collapse Biography 
    Collapse Education and Training
    University of North Texas, Denton, TXBS05/2004Biology
    University of Texas at San Antonio, San Antonio, TXMS05/2007Biology
    University of North Texas Health Science Center, Fort Worth, TXPhD05/2012Biomedical Sciences
    University of California, San Diego, San Diego, CAPostdoc03/2017Experimental Neuropathology

    Collapse Overview 
    Collapse Overview
    Our laboratory is focused on understanding and developing therapies for neurodegenerative diseases. We use molecular, neuropathological, and biochemical techniques to probe the mechanisms underlying the neurodegenerative processes in HIV associated neurocognitive disorder, HIV-sensory neuropathy and other neurodegenerative diseases. We are particularly interested in how alterations in mitochondrial function, chronic inflammation, disrupted autophagy, and the accumulation of protein aggregates underlie neurodegenerative processes. Our work includes examining postmortem brain specimens from humans and animal models to identify molecular and biochemical patterns and neuropathological signatures. We use in vitro models to dissect the neuropathogenic mechanisms and test therapeutic strategies in neurons, astrocytes, and microglia. Ultimately, the goal of our work is to identify therapeutic targets and treatments that will improve clinical outcomes for people suffering from neurological disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Mitochondrial biogenesis dysfunction in the CNS of HIV-infected individuals on antiretroviral therapy
    NIH/NIMH K01MH115819Feb 1, 2018 - Jan 31, 2021
    Role: Principal Investigator
    Development of Pirenzepine for HIV-SN
    NIH/NINDS R41NS105177Sep 28, 2017 - Aug 31, 2018
    Role: Co-Principal Investigator
    Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associated
    NIH/NINDS F32NS083426Apr 1, 2013 - Mar 31, 2015
    Role: Principal Investigator
    Regulation of Astrocyte TIMP-1 in HIV-Associated Dementia
    NIH/NINDS F31NS072006Apr 1, 2011 - Mar 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fields JA, Swinton MK, Soontornniyomkij B, Carson A, Achim CL. Beta amyloid levels in CSF of HIV-infected people vary by exposure to antiretroviral therapy. AIDS. 2020 Feb 17. PMID: 32073451.
      View in: PubMed
    2. Fields JA, Swinton MK, Carson A, Soontornniyomkij B, Lindsay C, Han MM, Frizzi K, Sambhwani S, Murphy A, Achim CL, Ellis RJ, Calcutt NA. Tenofovir disoproxil fumarate induces peripheral neuropathy and alters inflammation and mitochondrial biogenesis in the brains of mice. Sci Rep. 2019 Nov 20; 9(1):17158. PMID: 31748578.
      View in: PubMed
    3. Swinton MK, Carson A, Telese F, Sanchez AB, Soontornniyomkij B, Rad L, Batki I, Quintanilla B, Pérez-Santiago J, Achim CL, Letendre S, Ellis RJ, Grant I, Murphy AN, Fields JA. Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia. Neurobiol Dis. 2019 10; 130:104502. PMID: 31238091.
      View in: PubMed
    4. Fields JA, Ellis RJ. HIV in the cART era and the mitochondrial: immune interface in the CNS. Int Rev Neurobiol. 2019; 145:29-65. PMID: 31208526.
      View in: PubMed
    5. Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. Alterations in brain TREM2 and Amyloid-ß levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. J Neurochem. 2018 12; 147(6):784-802. PMID: 30152135.
      View in: PubMed
    6. Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating a-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018 08 09; 13(1):43. PMID: 30092810.
      View in: PubMed
    7. Kesby JP, Fields JA, Chang A, Coban H, Achim CL, Semenova S. Effects of HIV-1 TAT protein and methamphetamine exposure on visual discrimination and executive function in mice. Behav Brain Res. 2018 09 03; 349:73-79. PMID: 29709610.
      View in: PubMed
    8. Rozzi SJ, Avdoshina V, Fields JA, Mocchetti I. Human immunodeficiency virus Tat impairs mitochondrial fission in neurons. Cell Death Discov. 2018 Dec; 4:8. PMID: 29531805.
      View in: PubMed
    9. Thaney VE, Sanchez AB, Fields JA, Minassian A, Young JW, Maung R, Kaul M. Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research. J Neurovirol. 2018 04; 24(2):156-167. PMID: 29075998.
      View in: PubMed
    10. Rozzi SJ, Avdoshina V, Fields JA, Trejo M, Ton HT, Ahern GP, Mocchetti I. Human Immunodeficiency Virus Promotes Mitochondrial Toxicity. Neurotox Res. 2017 Nov; 32(4):723-733. PMID: 28695547.
      View in: PubMed
    11. Divakaruni AS, Wallace M, Buren C, Martyniuk K, Andreyev AY, Li E, Fields JA, Cordes T, Reynolds IJ, Bloodgood BL, Raymond LA, Metallo CM, Murphy AN. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017 04 03; 216(4):1091-1105. PMID: 28254829.
      View in: PubMed
    12. Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, Lee MH, Dickens AM, Haughey N, Dimitriadis EK, Nath A. HIV Tat protein and amyloid-ß peptide form multifibrillar structures that cause neurotoxicity. Nat Struct Mol Biol. 2017 04; 24(4):379-386. PMID: 28218748.
      View in: PubMed
    13. Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. PMID: 28105557.
      View in: PubMed
    14. Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathol Commun. 2017 01 05; 5(1):2. PMID: 28057080.
      View in: PubMed
    15. Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. J Neuroinflammation. 2016 05 24; 13(1):120. PMID: 27220536.
      View in: PubMed
    16. Avdoshina V, Fields JA, Castellano P, Dedoni S, Palchik G, Trejo M, Adame A, Rockenstein E, Eugenin E, Masliah E, Mocchetti I. The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotox Res. 2016 May; 29(4):583-593. PMID: 26936603.
      View in: PubMed
    17. Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiol Dis. 2016 Feb; 86:154-69. PMID: 26611103.
      View in: PubMed
    18. Fields J, Dumaop W, Eleuteri S, Elueteri S, Campos S, Serger E, Trejo M, Kosberg K, Adame A, Spencer B, Rockenstein E, He JJ, Masliah E. HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci. 2015 Feb 04; 35(5):1921-38. PMID: 25653352.
      View in: PubMed
    19. Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015; 13(1):43-54. PMID: 25760044.
      View in: PubMed
    20. Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on a-synuclein. Neuron. 2015 Jan 07; 85(1):76-87. PMID: 25533483.
      View in: PubMed
    21. Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathol. 2014 Apr; 127(4):477-94. PMID: 24509835.
      View in: PubMed
    22. Fields J, Dumaop W, Langford TD, Rockenstein E, Masliah E. Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders. J Neuroimmune Pharmacol. 2014 Mar; 9(2):102-16. PMID: 24510686.
      View in: PubMed
    23. Fields J, Dumaop W, Adame A, Ellis RJ, Letendre S, Grant I, Masliah E. Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders. J Neuroimmune Pharmacol. 2013 Dec; 8(5):1197-209. PMID: 24292993.
      View in: PubMed
    24. Fields J, Cisneros IE, Borgmann K, Ghorpade A. Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1ß-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression. PLoS One. 2013; 8(2):e56891. PMID: 23457635.
      View in: PubMed
    25. Fields J, Dumaop W, Rockenstein E, Mante M, Spencer B, Grant I, Ellis R, Letendre S, Patrick C, Adame A, Masliah E. Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. J Neurovirol. 2013 Feb; 19(1):89-101. PMID: 23341224.
      View in: PubMed
    26. Fields J, Ghorpade A. C/EBPß regulates multiple IL-1ß-induced human astrocyte inflammatory genes. J Neuroinflammation. 2012 Jul 20; 9:177. PMID: 22818222.
      View in: PubMed
    27. Fields J, Gardner-Mercer J, Borgmann K, Clark I, Ghorpade A. CCAAT/enhancer binding protein ß expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1. J Neurochem. 2011 Jul; 118(1):93-104. PMID: 21281310.
      View in: PubMed
    28. Kim MH, Fields J, Field J. Translationally regulated C/EBP beta isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells. Prostate. 2008 Sep 01; 68(12):1362-71. PMID: 18512730.
      View in: PubMed
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