Kevin Rynearson

Title(s)	Associate Project Scientist, Neurosciences
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606. Alzheimers Dement. 2024 Sep; 20(9):6107-6114. Godoy-Lugo JA, Thorwald MA, Cacciottolo M, D'Agostino C, Chakhoyan A, Sioutas C, Tanzi RE, Rynearson KD, Finch CE. PMID: 39132765; PMCID: PMC11497728.

View in: PubMed Mentions: 1 Fields:
Neu Neurology Psy Psychiatry
Translation:Animals PHPublic Health
γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome. Ann Neurol. 2024 Aug; 96(2):390-404. Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC. PMID: 38747498; PMCID: PMC11236496.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator. Ann Neurol. 2023 08; 94(2):245-258. Chen XQ, Sawa M, Becker A, Karachentsev D, Zuo X, Rynearson KD, Tanzi RE, Mobley WC. PMID: 37042072.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Humans Animals Cells
Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease. Alzheimers Dement. 2022 11; 18(11):2117-2130. Caldwell AB, Liu Q, Zhang C, Schroth GP, Galasko DR, Rynearson KD, Tanzi RE, Yuan SH, Wagner SL, Subramaniam S. PMID: 35084109; PMCID: PMC9787711.

View in: PubMed Mentions: 4 Fields:
Neu Neurology Psy Psychiatry
Translation:Humans Cells
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4). Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. PMID: 33651103; PMCID: PMC7931646.

View in: PubMed Mentions: 32 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Humans Animals Cells
Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. J Exp Med. 2020 12 07; 217(12). Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. PMID: 32936886; PMCID: PMC7553790.

View in: PubMed Mentions: 18 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Humans Animals
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 11 15; 28(22):115734. Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL. PMID: 33007551; PMCID: PMC7917164.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion. Langmuir. 2020 06 16; 36(23):6569-6579. Barros M, Houlihan WJ, Paresi CJ, Brendel M, Rynearson KD, Lee CW, Prikhodko O, Cregger C, Chang G, Wagner SL, Gilchrist ML, Li YM. PMID: 32432881; PMCID: PMC7887708.

View in: PubMed Mentions: 4 Fields:
Che Chemistry
Translation:Cells
The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. J Alzheimers Dis. 2020; 73(4):1541-1554. Prikhodko O, Rynearson KD, Sekhon T, Mante MM, Nguyen PD, Rissman RA, Tanzi RE, Wagner SL. PMID: 31958080.

View in: PubMed Mentions: 8 Fields:
Ger Geriatrics Neu Neurology
Translation:Humans Animals
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019 03 07; 24(3):363-375.e9. van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. PMID: 30686764; PMCID: PMC6414424.

View in: PubMed Mentions: 151 Fields:
Cel Cell Biology
Translation:Animals Cells
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. PMID: 28919280; PMCID: PMC5652037.

View in: PubMed Mentions: 12 Fields:
Gen Genetics Med Medicine (General)
Translation:Humans Animals Cells
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. PMID: 28416568; PMCID: PMC5454592.

View in: PubMed Mentions: 22 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Animals Cells
Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett. 2016 08 15; 26(16):3928-37. Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. PMID: 27426299.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3521-5. Rynearson KD, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM, Hermann T. PMID: 24930829; PMCID: PMC4114401.

View in: PubMed Mentions: 13 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells
Nanopore-based conformational analysis of a viral RNA drug target. ACS Nano. 2014 Jun 24; 8(6):6425-6430. Shasha C, Henley RY, Stoloff DH, Rynearson KD, Hermann T, Wanunu M. PMID: 24861167; PMCID: PMC4729693.

View in: PubMed Mentions: 21 Fields:
Nan Nanotechnology
Translation:Cells
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 2014 Feb 04; 53(4):702-13. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. PMID: 24401146; PMCID: PMC3929337.

View in: PubMed Mentions: 30 Fields:
Bio Biochemistry
Translation:Humans Cells
Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site. J Med Chem. 2014 Mar 13; 57(5):1694-707. Dibrov SM, Parsons J, Carnevali M, Zhou S, Rynearson KD, Ding K, Garcia Sega E, Brunn ND, Boerneke MA, Castaldi MP, Hermann T. PMID: 24138284; PMCID: PMC3954896.

View in: PubMed Mentions: 38 Fields:
Che Chemistry
Translation:Cells
Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA. Bioorg Med Chem. 2013 Oct 15; 21(20):6139-44. Zhou S, Rynearson KD, Ding K, Brunn ND, Hermann T. PMID: 23602522; PMCID: PMC3758467.

View in: PubMed Mentions: 18 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells PHPublic Health
1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams. Org Lett. 2010 Jan 15; 12(2):360-3. Dutta S, Higginson CJ, Ho BT, Rynearson KD, Dibrov SM, Hermann T. PMID: 20028082; PMCID: PMC2810123.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Cells