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Kevin Rynearson

Title(s)Assistant Project Scientist, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0624
La Jolla CA 92093
Phone000-000-NULL
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. J Exp Med. 2020 Dec 07; 217(12). Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. PMID: 32936886.
      View in: PubMed   Mentions:    Fields:    
    2. ?-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion. Langmuir. 2020 Jun 16; 36(23):6569-6579. Barros M, Houlihan WJ, Paresi CJ, Brendel M, Rynearson KD, Lee CW, Prikhodko O, Cregger C, Chang G, Wagner SL, Gilchrist ML, Li YM. PMID: 32432881.
      View in: PubMed   Mentions:    Fields:    
    3. The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. J Alzheimers Dis. 2020; 73(4):1541-1554. Prikhodko O, Rynearson KD, Sekhon T, Mante MM, Nguyen PD, Rissman RA, Tanzi RE, Wagner SL. PMID: 31958080.
      View in: PubMed   Mentions:    Fields:    
    4. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-ß in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019 03 07; 24(3):363-375.e9. van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. PMID: 30686764.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    5. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. PMID: 28919280.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. PMID: 28416568.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    7. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett. 2016 08 15; 26(16):3928-37. Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. PMID: 27426299.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. 2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3521-5. Rynearson KD, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM, Hermann T. PMID: 24930829.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    9. Nanopore-based conformational analysis of a viral RNA drug target. ACS Nano. 2014 Jun 24; 8(6):6425-6430. Shasha C, Henley RY, Stoloff DH, Rynearson KD, Hermann T, Wanunu M. PMID: 24861167.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    10. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. PMID: 24401146.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    11. Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site. J Med Chem. 2014 Mar 13; 57(5):1694-707. Dibrov SM, Parsons J, Carnevali M, Zhou S, Rynearson KD, Ding K, Garcia Sega E, Brunn ND, Boerneke MA, Castaldi MP, Hermann T. PMID: 24138284.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    12. Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA. Bioorg Med Chem. 2013 Oct 15; 21(20):6139-44. Zhou S, Rynearson KD, Ding K, Brunn ND, Hermann T. PMID: 23602522.
      View in: PubMed   Mentions: 12     Fields:    Translation:CellsPHPublic Health
    13. 1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams. Org Lett. 2010 Jan 15; 12(2):360-3. Dutta S, Higginson CJ, Ho BT, Rynearson KD, Dibrov SM, Hermann T. PMID: 20028082.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
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