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    Kevin Rynearson

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0624
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson K, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Sep 04. PMID: 28919280.
        View in: PubMed
      2. Wagner SL, Rynearson K, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. Pharmacological and Toxicological Properties of the Potent Oral ?-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul; 362(1):31-44. PMID: 28416568.
        View in: PubMed
      3. Rynearson K, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett. 2016 Aug 15; 26(16):3928-37. PMID: 27426299.
        View in: PubMed
      4. Rynearson K, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM, Hermann T. 2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3521-5. PMID: 24930829; PMCID: PMC4114401.
      5. Shasha C, Henley RY, Stoloff DH, Rynearson K, Hermann T, Wanunu M. Nanopore-based conformational analysis of a viral RNA drug target. ACS Nano. 2014 Jun 24; 8(6):6425-30. PMID: 24861167.
        View in: PubMed
      6. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson K, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species. Biochemistry. 2014 Feb 04; 53(4):702-13. PMID: 24401146; PMCID: PMC3929337.
      7. Dibrov SM, Parsons J, Carnevali M, Zhou S, Rynearson K, Ding K, Garcia Sega E, Brunn ND, Boerneke MA, Castaldi MP, Hermann T. Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site. J Med Chem. 2014 Mar 13; 57(5):1694-707. PMID: 24138284; PMCID: PMC3954896.
      8. Zhou S, Rynearson K, Ding K, Brunn ND, Hermann T. Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA. Bioorg Med Chem. 2013 Oct 15; 21(20):6139-44. PMID: 23602522; PMCID: PMC3758467.
      9. Dutta S, Higginson CJ, Ho BT, Rynearson K, Dibrov SM, Hermann T. 1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams. Org Lett. 2010 Jan 15; 12(2):360-3. PMID: 20028082; PMCID: PMC2810123.
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