Steven Wagner

Title(s)Professor In Residence, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    A Single Ascending Dose / Multiple Ascending Dose Phase I study of the GSM 776890 in healthy normal subjects
    NIH R01AG070353Feb 1, 2021 - Nov 30, 2023
    Role: Principal Investigator
    A Dominantly Inherited AD network In Vitro Trial with a Gamma-Secretase Modulator
    NIH I01RX002259Jun 1, 2017 - May 31, 2021
    Role: Principal Investigator
    Optimization and preclinical development of soluble gamma-secretase modulators for AD
    NIH U01AG048986May 15, 2016 - Apr 30, 2020
    Role: Principal Investigator
    Translational Center for Alzheimer's Disease Target and Drug Discovery
    NIH R34AG049646Sep 30, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Polytherapy for AD: Combining Gamma-secretase Modulation and CRFR1 Antagonism
    NIH R21AG047484Sep 1, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Optimization of Soluble Gamma-secretase Modulators for the Treatment of Alzheimer
    NIH U01NS074501Jul 1, 2011 - Jun 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease. Alzheimers Dement. 2022 Nov; 18(11):2117-2130. Caldwell AB, Liu Q, Zhang C, Schroth GP, Galasko DR, Rynearson KD, Tanzi RE, Yuan SH, Wagner SL, Subramaniam S. PMID: 35084109.
      View in: PubMed   Mentions:    Fields:    
    2. Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4). Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. PMID: 33651103; PMCID: PMC7931646.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    3. Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:434-450. Wang S, Leem JS, Podvin S, Hook V, Kleschevnikov N, Savchenko P, Dhanani M, Zhou K, Kelly IC, Zhang T, Miyanohara A, Nguyen P, Kleschevnikov A, Wagner SL, Trojanowski JQ, Roth DM, Patel HH, Patel PM, Head BP. PMID: 33981778; PMCID: PMC8065227.
      View in: PubMed   Mentions: 4  
    4. Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. J Exp Med. 2020 12 07; 217(12). Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. PMID: 32936886; PMCID: PMC7553790.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    5. Dedifferentiation and neuronal repression define familial Alzheimer's disease. Sci Adv. 2020 11; 6(46). Caldwell AB, Liu Q, Schroth GP, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. PMID: 33188013; PMCID: PMC7673760.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 11 15; 28(22):115734. Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL. PMID: 33007551; PMCID: PMC7917164.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion. Langmuir. 2020 06 16; 36(23):6569-6579. Barros M, Houlihan WJ, Paresi CJ, Brendel M, Rynearson KD, Lee CW, Prikhodko O, Cregger C, Chang G, Wagner SL, Gilchrist ML, Li YM. PMID: 32432881; PMCID: PMC7887708.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    8. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease. Nat Commun. 2020 03 13; 11(1):1377. Kwak SS, Washicosky KJ, Brand E, von Maydell D, Aronson J, Kim S, Capen DE, Cetinbas M, Sadreyev R, Ning S, Bylykbashi E, Xia W, Wagner SL, Choi SH, Tanzi RE, Kim DY. PMID: 32170138; PMCID: PMC7070004.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    9. The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. J Alzheimers Dis. 2020; 73(4):1541-1554. Prikhodko O, Rynearson KD, Sekhon T, Mante MM, Nguyen PD, Rissman RA, Tanzi RE, Wagner SL. PMID: 31958080.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    10. APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model. Cell Rep. 2019 04 30; 27(5):1345-1355.e6. Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT. PMID: 31042463; PMCID: PMC6508668.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem. 2019 03 22; 294(12):4477-4487. Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, Thinakaran G. PMID: 30692199; PMCID: PMC6433054.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    12. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019 03 07; 24(3):363-375.e9. van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. PMID: 30686764; PMCID: PMC6414424.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    13. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9665-E9674. Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G. PMID: 29078331; PMCID: PMC5692556.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    14. Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. PMID: 28919280; PMCID: PMC5652037.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. PMID: 28416568; PMCID: PMC5454592.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett. 2016 08 15; 26(16):3928-37. Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. PMID: 27426299.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089; PMCID: PMC4782935.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    18. γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation. FASEB J. 2015 Aug; 29(8):3335-41. D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM. PMID: 25903103; PMCID: PMC4511200.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. PMID: 25710492; PMCID: PMC4339551.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    20. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. PMID: 25285942; PMCID: PMC4374637.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    21. A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. J Biol Chem. 2014 Dec 12; 289(50):34851-61. Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. PMID: 25352592; PMCID: PMC4263884.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. PMID: 25307057; PMCID: PMC4366007.
      View in: PubMed   Mentions: 410     Fields:    Translation:HumansCells
    23. Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 2014 Feb 04; 53(4):702-13. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. PMID: 24401146; PMCID: PMC3929337.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    24. Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion. J Biol Chem. 2013 Sep 13; 288(37):26955-66. Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PD, Wagner SL, Villereal ML, Thinakaran G. PMID: 23902769; PMCID: PMC3772244.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    25. Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8. Wagner SL, Tanzi RE, Mobley WC, Galasko D. PMID: 22801784; PMCID: PMC3747667.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    26. Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein. J Biol Chem. 2011 Jul 22; 286(29):26166-77. Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G. PMID: 21642424; PMCID: PMC3138254.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    27. And four equals one: presenilin takes the gamma-secretase role by itself. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21236-7. Lessard CB, Wagner SL, Koo EH. PMID: 21135249; PMCID: PMC3003118.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem. 2010 Dec 03; 285(49):38042-52. Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G. PMID: 20921220; PMCID: PMC2992238.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    29. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. PMID: 20826309; PMCID: PMC2947312.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    30. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009 Dec; 119(12):3692-702. Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K. PMID: 19907078; PMCID: PMC2786797.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    31. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet. 2009 Oct 15; 18(20):3987-96. Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. PMID: 19608551; PMCID: PMC2748890.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    32. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. PMID: 18976728; PMCID: PMC2668052.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansCells
    33. Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? J Med Genet. 2007 Jan; 44(1):e63. Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE. PMID: 17209133; PMCID: PMC2597918.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    34. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. PMID: 16945923.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    35. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005 May 09; 169(3):435-45. Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA. PMID: 15866891; PMCID: PMC2171946.
      View in: PubMed   Mentions: 847     Fields:    Translation:HumansAnimalsCells
    36. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med. 2005 Mar 03; 352(9):884-94. Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. PMID: 15745979.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    37. Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. Biochem Pharmacol. 2005 Feb 15; 69(4):689-98. Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. PMID: 15670587.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    38. ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. J Biol Chem. 2004 Dec 24; 279(52):54216-20. Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB. PMID: 15494400.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    39. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004 Jan 15; 13(2):159-70. Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. PMID: 14645205.
      View in: PubMed   Mentions: 657     Fields:    Translation:HumansAnimalsCells
    40. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet. 2003 Nov 01; 12(21):2765-76. Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D. PMID: 12966032.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
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