Corina Antal

Title(s)Assistant Professor In Residence, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-6174-4930 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UC San Diego, La Jolla, CAPh.D.05/2015Biomedical Sciences
    University of Miami, Miami, FLB.S.06/2009Biology and Marine Science
    Collapse Awards and Honors
    Salk Institute for Biological Studies2016  - 2020Damon Runyon Robert Black Fellowship
    Fred Hutchinson Cancer Research Center2016Harold M. Weintraub Graduate Student Award
    2016Theodore Puck Award
    UC San Diego2015BMS Outstanding Dissertation Award
    Forbes2015Forbes 30 Under 30 in Science
    UC San Diego2011  - 2014NSF Graduate Research Fellowship
    UC San Diego2024  - 2027V Foundation Scholar Award

    Collapse Overview 
    Collapse Overview
    Cancer arises from the concerted action of genetic mutations and epigenetic changes that lead to transcriptional alterations, ultimately impacting signal transduction. Our interests lie in investigating the interplay between epigenetics, RNA processing, and cell signaling to uncover new mechanisms underlying cancer progression. Our research goals are to identify novel epigenetic vulnerabilities in cancer and to elucidate mechanisms of posttranslational regulation of RNA-binding proteins that play a key role in tumorigenesis, in an effort to uncover new therapeutic approaches for cancer treatment. Dr. Antal’s laboratory uses a multidisciplinary approach to investigate the molecular underpinnings of pancreatic cancer progression, including epigenomics, high-throughput CRISPR and DNA base editing screens, computational approaches, and mouse models of pancreatic cancer.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. Nat Commun. 2023 Dec 06; 14(1):7791. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 38057326; PMCID: PMC10700526.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression. bioRxiv. 2023 Sep 14. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 37745372; PMCID: PMC10515810.
      View in: PubMed   Mentions:
    3. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023 09 06; 14(1):5195. Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. PMID: 37673892; PMCID: PMC10482938.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2021 Dec; 600(7889):E18. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 34848876.
      View in: PubMed   Mentions: 1     Fields:    
    5. Protein kinase C fusion proteins are paradoxically loss of function in cancer. J Biol Chem. 2021 Jan-Jun; 296:100445. Van AN, Kunkel MT, Baffi TR, Lordén G, Antal CE, Banerjee S, Newton AC. PMID: 33617877; PMCID: PMC8008189.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    6. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis. 2020 Nov 09; 9(11):100. Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. PMID: 33168807; PMCID: PMC7653036.
      View in: PubMed   Mentions: 29  
    7. Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. Cancer Res. 2020 10 15; 80(20):4324-4334. Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee JH, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. PMID: 32928922; PMCID: PMC7906529.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    8. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 30996350; PMCID: PMC6565370.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    9. Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond). 2016 09 01; 130(17):1499-510. Newton AC, Antal CE, Steinberg SF. PMID: 27433023; PMCID: PMC5024564.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    10. Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Sci Signal. 2016 05 10; 9(427):ra47. Alfonso SI, Callender JA, Hooli B, Antal CE, Mullin K, Sherman MA, Lesné SE, Leitges M, Newton AC, Tanzi RE, Malinow R. PMID: 27165780; PMCID: PMC5154619.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    11. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Rep. 2015 Aug 25; 12(8):1252-60. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. PMID: 26279568; PMCID: PMC4551583.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    12. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015 Jan 29; 160(3):489-502. Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC. PMID: 25619690; PMCID: PMC4313737.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    13. Tuning the signalling output of protein kinase C. Biochem Soc Trans. 2014 Dec; 42(6):1477-83. Antal CE, Newton AC. PMID: 25399557; PMCID: PMC5783555.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    14. Intramolecular conformational changes optimize protein kinase C signaling. Chem Biol. 2014 Apr 24; 21(4):459-469. Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC. PMID: 24631122; PMCID: PMC4020788.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    15. Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics. 2013 Dec; 12(12):3498-508. Antal CE, Newton AC. PMID: 23788531; PMCID: PMC3861703.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    16. Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα. J Biol Chem. 2013 Jun 07; 288(23):16905-16915. Scott AM, Antal CE, Newton AC. PMID: 23589289; PMCID: PMC3675623.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    17. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chem Biol. 2012 Aug 24; 19(8):994-1000. de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. PMID: 22921066; PMCID: PMC4079670.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    18. The effect of short-term hypoxic exposure on metabolic gene expression. J Exp Zool A Ecol Genet Physiol. 2012 Jan 01; 317(1):9-23. Everett MV, Antal CE, Crawford DL. PMID: 22021243; PMCID: PMC3237964.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    19. Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem. 2011 Aug 19; 286(33):28922-28930. Gould CM, Antal CE, Reyes G, Kunkel MT, Adams RA, Ziyar A, Riveros T, Newton AC. PMID: 21715334; PMCID: PMC3190699.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
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