David Dubowitz

Title(s)Emeritus Professor, Radiology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    California Institute of TechnologyPh.D.
    Huntington Medical Research InstitutesFellowshipMagnetic Resonance Spectroscopy
    University of CambridgeResidencyRadiology
    University of OxfordResidencyInternal Medicine
    University of OxfordM.D.Medicine
    University of CambridgeB.S. and M.S.Electrical Engineering

    Collapse Overview 
    Collapse Overview
    David Dubowitz, MD PhD, is a radiologist and neuroscientist. He received his bachelor and master degrees in Electrical Engineering from the University of Cambridge, England. His medical training was at University of Oxford, England, and he has completed residencies in Internal Medicine at Oxford, and Radiology at Cambridge. He is also did a fellowship in Magnetic Resonance Spectroscopy at Huntington Medical Research Institutes in Pasadena, CA. His PhD is from California Institute of Technology where he also did postdoctoral research on functional MRI of cerebral physiology in the primate brain.

    He joined the UCSD faculty in 2002, working primarily at the UCSD Center for Functional Magnetic Resonance Imaging, where he serves as Associate Director. His primary research interests are is in the field of magnetic resonance imaging, focusing on the basic physiology of functional MRI, both in humans and in other animals, and MRI measurements of cerebral blood flow and metabolism, particularly as they apply to acclimatization and deacclimatization to hypoxia at altitude. He also has research interests in MRI measurements of pulmonary blood flow, and in magnetic resonance spectroscopy (MRS).

    Collapse Research 
    Collapse Research Activities and Funding
    Cerebral Diffusion: A new approach to sleep disorders
    NIH R21HL138075Aug 4, 2017 - Jul 31, 2021
    Role: Principal Investigator
    MRI of cerebral metabolic reactivity
    NIH R21NS091709Sep 1, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Hemodynamic and Metabolic Coupling in Migraine
    NIH R21NS085639Sep 15, 2013 - Aug 31, 2016
    Role: Principal Investigator
    Tissue Oxygenation and Cerebral Vulnerability to Hypoxia
    NIH R21NS075812Feb 15, 2012 - Jan 31, 2015
    Role: Principal Investigator
    Cerebral Response to Sustained Hypoxia
    NIH R01NS053934Jun 15, 2007 - May 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Morphology of the Amazonian Teleost Genus Arapaima Using Advanced 3D Imaging. Front Physiol. 2020; 11:260. Scadeng M, McKenzie C, He W, Bartsch H, Dubowitz DJ, Stec D, St Leger J. PMID: 32395105; PMCID: PMC7197331.
      View in: PubMed   Mentions:
    2. On the Quality, Statistical Efficiency, and Safety of Simultaneously Recorded Multiband fMRI/EEG. Brain Topogr. 2020 05; 33(3):303-316. Chen JCC, Forsyth A, Dubowitz DJ, Muthukumaraswamy SD. PMID: 32144628.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    3. Multi-modal normalization of resting-state using local physiology reduces changes in functional connectivity patterns observed in mTBI patients. Neuroimage Clin. 2020; 26:102204. Champagne AA, Coverdale NS, Ross A, Chen Y, Murray CI, Dubowitz D, Cook DJ. PMID: 32058317; PMCID: PMC7013121.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. The potential for gas-free measurements of absolute oxygen metabolism during both baseline and activation states in the human brain. Neuroimage. 2020 02 15; 207:116342. Liu EY, Guo J, Simon AB, Haist F, Dubowitz DJ, Buxton RB. PMID: 31722231; PMCID: PMC6995433.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. Cerebral blood volume changes during the BOLD post-stimulus undershoot measured with a combined normoxia/hyperoxia method. Neuroimage. 2019 01 15; 185:154-163. Liu EY, Haist F, Dubowitz DJ, Buxton RB. PMID: 30315908; PMCID: PMC6292691.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Evidence from high-altitude acclimatization for an integrated cerebrovascular and ventilatory hypercapnic response but different responses to hypoxia. J Appl Physiol (1985). 2017 12 01; 123(6):1477-1486. Smith ZM, Krizay E, Sá RC, Li ET, Scadeng M, Powell FL, Dubowitz DJ. PMID: 28705997; PMCID: PMC6734088.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Susceptibility to high-altitude pulmonary edema is associated with a more uniform distribution of regional specific ventilation. J Appl Physiol (1985). 2017 Apr 01; 122(4):844-852. Patz MD, Sá RC, Darquenne C, Elliott AR, Asadi AK, Theilmann RJ, Dubowitz DJ, Swenson ER, Prisk GK, Hopkins SR. PMID: 28057815; PMCID: PMC5407202.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations. Neuroimage. 2016 Apr 01; 129:198-213. Simon AB, Dubowitz DJ, Blockley NP, Buxton RB. PMID: 26790354; PMCID: PMC4830424.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Acetazolamide during acute hypoxia improves tissue oxygenation in the human brain. J Appl Physiol (1985). 2015 Dec 15; 119(12):1494-500. Wang K, Smith ZM, Buxton RB, Swenson ER, Dubowitz DJ. PMID: 26472861; PMCID: PMC4683345.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Calibrating the BOLD response without administering gases: comparison of hypercapnia calibration with calibration using an asymmetric spin echo. Neuroimage. 2015 Jan 01; 104:423-9. Blockley NP, Griffeth VE, Simon AB, Dubowitz DJ, Buxton RB. PMID: 25451475; PMCID: PMC4803316.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    11. The effect of supine exercise on the distribution of regional pulmonary blood flow measured using proton MRI. J Appl Physiol (1985). 2014 Feb 15; 116(4):451-61. Hall ET, Sá RC, Holverda S, Arai TJ, Dubowitz DJ, Theilmann RJ, Prisk GK, Hopkins SR. PMID: 24356515; PMCID: PMC3921353.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Cerebral diffusion and T(2): MRI predictors of acute mountain sickness during sustained high-altitude hypoxia. J Cereb Blood Flow Metab. 2013 Mar; 33(3):372-80. Hunt JS, Theilmann RJ, Smith ZM, Scadeng M, Dubowitz DJ. PMID: 23211961; PMCID: PMC3587813.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    13. Sustained high-altitude hypoxia increases cerebral oxygen metabolism. J Appl Physiol (1985). 2013 Jan 01; 114(1):11-8. Smith ZM, Krizay E, Guo J, Shin DD, Scadeng M, Dubowitz DJ. PMID: 23019310; PMCID: PMC3544513.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    14. A frameless stereotaxic MRI technique for macaque neuroscience studies. Open Neuroimag J. 2011; 5:198-205. Dubowitz DJ, Scadeng M. PMID: 22253662; PMCID: PMC3257065.
      View in: PubMed   Mentions: 3  
    15. Measuring lung water: ex vivo validation of multi-image gradient echo MRI. J Magn Reson Imaging. 2011 Jul; 34(1):220-4. Holverda S, Theilmann RJ, Sá RC, Arai TJ, Hall ET, Dubowitz DJ, Prisk GK, Hopkins SR. PMID: 21698711; PMCID: PMC3122154.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    16. Clinical pitfalls related to short and long echo times in cerebral MR spectroscopy. J Neuroradiol. 2011 May; 38(2):69-75. Cianfoni A, Law M, Re TJ, Dubowitz DJ, Rumboldt Z, Imbesi SG. PMID: 21215455.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    17. Vertical distribution of specific ventilation in normal supine humans measured by oxygen-enhanced proton MRI. J Appl Physiol (1985). 2010 Dec; 109(6):1950-9. Sá RC, Cronin MV, Henderson AC, Holverda S, Theilmann RJ, Arai TJ, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. PMID: 20930129; PMCID: PMC3006418.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    18. Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans. J Appl Physiol (1985). 2009 Nov; 107(5):1559-68. Burnham KJ, Arai TJ, Dubowitz DJ, Henderson AC, Holverda S, Buxton RB, Prisk GK, Hopkins SR. PMID: 19745192; PMCID: PMC2777793.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    19. Quantitative MRI measurement of lung density must account for the change in T(2) (*) with lung inflation. J Magn Reson Imaging. 2009 Sep; 30(3):527-34. Theilmann RJ, Arai TJ, Samiee A, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. PMID: 19630079; PMCID: PMC3354915.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    20. Early brain swelling in acute hypoxia. J Appl Physiol (1985). 2009 Jul; 107(1):244-52. Dubowitz DJ, Dyer EA, Theilmann RJ, Buxton RB, Hopkins SR. PMID: 19423837; PMCID: PMC2711789.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    21. Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans. J Appl Physiol (1985). 2009 Apr; 106(4):1057-64. Arai TJ, Henderson AC, Dubowitz DJ, Levin DL, Friedman PJ, Buxton RB, Prisk GK, Hopkins SR. PMID: 19057006; PMCID: PMC2698636.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    22. Regional cerebral blood flow during acute hypoxia in individuals susceptible to acute mountain sickness. Respir Physiol Neurobiol. 2008 Feb 29; 160(3):267-76. Dyer EA, Hopkins SR, Perthen JE, Buxton RB, Dubowitz DJ. PMID: 18088570; PMCID: PMC2387187.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. CBF/CMRO2 coupling measured with calibrated BOLD fMRI: sources of bias. Neuroimage. 2007 Jul 15; 36(4):1110-22. Leontiev O, Dubowitz DJ, Buxton RB. PMID: 17524665; PMCID: PMC2038985.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    24. Magnetic resonance imaging of the visual system in vivo: transsynaptic illumination of V1 and V2 visual cortex. Neuroimage. 2007 Feb 15; 34(4):1619-26. Lindsey JD, Scadeng M, Dubowitz DJ, Crowston JG, Weinreb RN. PMID: 17204432.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    25. High-resolution three-dimensional magnetic resonance imaging of mouse lung in situ. Invest Radiol. 2007 Jan; 42(1):50-7. Scadeng M, Rossiter HB, Dubowitz DJ, Breen EC. PMID: 17213749.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    26. Functional imaging of dolphin brain metabolism and blood flow. J Exp Biol. 2006 Aug; 209(Pt 15):2902-10. Ridgway S, Houser D, Finneran J, Carder D, Keogh M, Van Bonn W, Smith C, Scadeng M, Dubowitz D, Mattrey R, Hoh C. PMID: 16857874.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    27. Caffeine alters the temporal dynamics of the visual BOLD response. Neuroimage. 2004 Dec; 23(4):1402-13. Liu TT, Behzadi Y, Restom K, Uludag K, Lu K, Buracas GT, Dubowitz DJ, Buxton RB. PMID: 15589104.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    28. Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI. Neuroimage. 2004 Sep; 23(1):148-55. Uludag K, Dubowitz DJ, Yoder EJ, Restom K, Liu TT, Buxton RB. PMID: 15325361.
      View in: PubMed   Mentions: 100     Fields:    Translation:Humans
    29. Modeling the hemodynamic response to brain activation. Neuroimage. 2004; 23 Suppl 1:S220-33. Buxton RB, Uludag K, Dubowitz DJ, Liu TT. PMID: 15501093.
      View in: PubMed   Mentions: 355     Fields:    Translation:HumansCells
    30. Direct comparison of visual cortex activation in human and nonhuman primates using functional magnetic resonance imaging. Methods Enzymol. 2004; 385:102-34. Dubowitz DJ. PMID: 15130736.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    31. Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus. J Neurosci Methods. 2003 Nov 30; 130(1):1-8. Scherberger H, Fineman I, Musallam S, Dubowitz DJ, Bernheim KA, Pesaran B, Corneil BD, Gilliken B, Andersen RA. PMID: 14583399.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    32. Micro-MRI at 11.7 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging. 2003 Jul; 2(3):150-8. Moats RA, Velan-Mullan S, Jacobs R, Gonzalez-Gomez I, Dubowitz DJ, Taga T, Khankaldyyan V, Schultz L, Fraser S, Nelson MD, Laug WE. PMID: 14649058.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    33. Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biol Psychiatry. 2002 Feb 01; 51(3):216-23. McDowell JE, Brown GG, Paulus M, Martinez A, Stewart SE, Dubowitz DJ, Braff DL. PMID: 11839364.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    34. Enhancing fMRI contrast in awake-behaving primates using intravascular magnetite dextran nanopartieles. Neuroreport. 2001 08 08; 12(11):2335-40. Dubowitz DJ, Bernheim KA, Chen DY, Bradley WG, Andersen RA. PMID: 11496106.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    35. Peripheral somatosensory fMRI in mouse at 11.7 T. NMR Biomed. 2001 Aug; 14(5):318-24. Ahrens ET, Dubowitz DJ. PMID: 11477652.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    36. Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging. J Neurosci Methods. 2001 May 30; 107(1-2):71-80. Dubowitz DJ, Chen DY, Atkinson DJ, Scadeng M, Martinez A, Andersen MB, Andersen RA, Bradley WG. PMID: 11389943.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    37. High resolution magnetic resonance imaging of the brain in the dy/dy mouse with merosin-deficient congenital muscular dystrophy. Neuromuscul Disord. 2000 Jun; 10(4-5):292-8. Dubowitz DJ, Tyszka JM, Sewry CA, Moats RA, Scadeng M, Dubowitz V. PMID: 10838257.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    38. In vivo magnetic resonance spectroscopy of human fetal neural transplants. NMR Biomed. 1999 Jun; 12(4):221-36. Ross BD, Hoang TQ, Blüml S, Dubowitz D, Kopyov OV, Jacques DB, Lin A, Seymour K, Tan J. PMID: 10421914.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    39. Involvement of striate and extrastriate visual cortical areas in spatial attention. Nat Neurosci. 1999 Apr; 2(4):364-9. Martínez A, Anllo-Vento L, Sereno MI, Frank LR, Buxton RB, Dubowitz DJ, Wong EC, Hinrichs H, Heinze HJ, Hillyard SA. PMID: 10204544.
      View in: PubMed   Mentions: 224     Fields:    Translation:Humans
    40. MR of hypoxic encephalopathy in children after near drowning: correlation with quantitative proton MR spectroscopy and clinical outcome. AJNR Am J Neuroradiol. 1998 Oct; 19(9):1617-27. Dubowitz DJ, Bluml S, Arcinue E, Dietrich RB. PMID: 9802481; PMCID: PMC8337494.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    41. Functional magnetic resonance imaging in macaque cortex. Neuroreport. 1998 Jul 13; 9(10):2213-8. Dubowitz DJ, Chen DY, Atkinson DJ, Grieve KL, Gillikin B, Bradley WG, Andersen RA. PMID: 9694202.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    42. Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain. Magn Reson Med. 1998 Jun; 39(6):1005-10. Tan J, Bluml S, Hoang T, Dubowitz D, Mevenkamp G, Ross B. PMID: 9621925.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    43. Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases. Neurology. 1998 Apr; 50(4):1033-40. Hoang TQ, Bluml S, Dubowitz DJ, Moats R, Kopyov O, Jacques D, Ross BD. PMID: 9566391.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    44. Problem in diagnostic imaging. Clin Anat. 1997; 10(4):279-82. Dubowitz DJ. PMID: 9213047.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Correspondence. Quantitative perfusion parameters of focal nodular hyperplasia and normal liver parenchyma as determined by electron beam tomography. Br J Radiol. 1996 Jun; 69(822):577. Dubowitz DJ, Miles KA. PMID: 8757665.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Technical note: bone SPECT of the wrist. Br J Radiol. 1994 Sep; 67(801):890-3. Dubowitz DJ, Miles KA. PMID: 7953231.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    47. Portable version of Fantz box for assessment of visual function. Lancet. 1980 Dec 13; 2(8207):1279-80. Dubowitz D. PMID: 6108451.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. [Some questions on overcoming the differences between the city and the country in the medical field]. Z Arztl Fortbild (Jena). 1961 Apr 15; 55:456-8. DUBOWITZ D. PMID: 13724665.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
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