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David Dubowitz

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentRadiology
Address9500 Gilman Drive #0677
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    California Institute of TechnologyPh.D.
    Huntington Medical Research InstitutesFellowshipMagnetic Resonance Spectroscopy
    University of CambridgeResidencyRadiology
    University of OxfordResidencyInternal Medicine
    University of OxfordM.D.Medicine
    University of CambridgeB.S. and M.S.Electrical Engineering

    Collapse Overview 
    Collapse Overview
    David Dubowitz, MD PhD, is a radiologist and neuroscientist. He received his bachelor and master degrees in Electrical Engineering from the University of Cambridge, England. His medical training was at University of Oxford, England, and he has completed residencies in Internal Medicine at Oxford, and Radiology at Cambridge. He is also did a fellowship in Magnetic Resonance Spectroscopy at Huntington Medical Research Institutes in Pasadena, CA. His PhD is from California Institute of Technology where he also did postdoctoral research on functional MRI of cerebral physiology in the primate brain.

    He joined the UCSD faculty in 2002, working primarily at the UCSD Center for Functional Magnetic Resonance Imaging, where he serves as Associate Director. His primary research interests are is in the field of magnetic resonance imaging, focusing on the basic physiology of functional MRI, both in humans and in other animals, and MRI measurements of cerebral blood flow and metabolism, particularly as they apply to acclimatization and deacclimatization to hypoxia at altitude. He also has research interests in MRI measurements of pulmonary blood flow, and in magnetic resonance spectroscopy (MRS).


    Collapse Research 
    Collapse Research Activities and Funding
    Cerebral Diffusion: A new approach to sleep disorders
    NIH/NHLBI R21HL138075Aug 4, 2017 - Jul 31, 2019
    Role: Principal Investigator
    MRI of cerebral metabolic reactivity
    NIH/NINDS R21NS091709Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Hemodynamic and Metabolic Coupling in Migraine
    NIH/NINDS R21NS085639Sep 15, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Tissue Oxygenation and Cerebral Vulnerability to Hypoxia
    NIH/NINDS R21NS075812Feb 15, 2012 - Jan 31, 2014
    Role: Principal Investigator
    Cerebral Response to Sustained Hypoxia
    NIH/NINDS R01NS053934Jun 15, 2007 - May 31, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Smith ZM, Krizay E, Sá RC, Li ET, Scadeng M, Powell FL, Dubowitz DJ. Evidence from high-altitude acclimatization for an integrated cerebrovascular and ventilatory hypercapnic response but different responses to hypoxia. J Appl Physiol (1985). 2017 12 01; 123(6):1477-1486. PMID: 28705997.
      View in: PubMed
    2. Patz MD, Sá RC, Darquenne C, Elliott AR, Asadi AK, Theilmann RJ, Dubowitz DJ, Swenson ER, Prisk GK, Hopkins SR. Susceptibility to high-altitude pulmonary edema is associated with a more uniform distribution of regional specific ventilation. J Appl Physiol (1985). 2017 Apr 01; 122(4):844-852. PMID: 28057815.
      View in: PubMed
    3. Simon AB, Dubowitz DJ, Blockley NP, Buxton RB. A novel Bayesian approach to accounting for uncertainty in fMRI-derived estimates of cerebral oxygen metabolism fluctuations. Neuroimage. 2016 Apr 01; 129:198-213. PMID: 26790354; PMCID: PMC4830424 [Available on 04/01/17].
    4. Wang K, Smith ZM, Buxton RB, Swenson ER, Dubowitz DJ. Acetazolamide during acute hypoxia improves tissue oxygenation in the human brain. J Appl Physiol (1985). 2015 Dec 15; 119(12):1494-500. PMID: 26472861; PMCID: PMC4683345 [Available on 12/15/16].
    5. Blockley NP, Griffeth VE, Simon AB, Dubowitz DJ, Buxton RB. Calibrating the BOLD response without administering gases: comparison of hypercapnia calibration with calibration using an asymmetric spin echo. Neuroimage. 2015 Jan 01; 104:423-9. PMID: 25451475; PMCID: PMC4803316.
    6. Hall ET, Sá RC, Holverda S, Arai TJ, Dubowitz DJ, Theilmann RJ, Prisk GK, Hopkins SR. The effect of supine exercise on the distribution of regional pulmonary blood flow measured using proton MRI. J Appl Physiol (1985). 2014 Feb 15; 116(4):451-61. PMID: 24356515; PMCID: PMC3921353.
    7. Hunt JS, Theilmann RJ, Smith ZM, Scadeng M, Dubowitz DJ. Cerebral diffusion and T(2): MRI predictors of acute mountain sickness during sustained high-altitude hypoxia. J Cereb Blood Flow Metab. 2013 Mar; 33(3):372-80. PMID: 23211961; PMCID: PMC3587813.
    8. Smith ZM, Krizay E, Guo J, Shin DD, Scadeng M, Dubowitz DJ. Sustained high-altitude hypoxia increases cerebral oxygen metabolism. J Appl Physiol (1985). 2013 Jan 01; 114(1):11-8. PMID: 23019310; PMCID: PMC3544513.
    9. Dubowitz DJ, Scadeng M. A frameless stereotaxic MRI technique for macaque neuroscience studies. Open Neuroimag J. 2011; 5:198-205. PMID: 22253662; PMCID: PMC3257065.
    10. Holverda S, Theilmann RJ, Sá RC, Arai TJ, Hall ET, Dubowitz DJ, Prisk GK, Hopkins SR. Measuring lung water: ex vivo validation of multi-image gradient echo MRI. J Magn Reson Imaging. 2011 Jul; 34(1):220-4. PMID: 21698711; PMCID: PMC3122154.
    11. Sá RC, Cronin MV, Henderson AC, Holverda S, Theilmann RJ, Arai TJ, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. Vertical distribution of specific ventilation in normal supine humans measured by oxygen-enhanced proton MRI. J Appl Physiol (1985). 2010 Dec; 109(6):1950-9. PMID: 20930129; PMCID: PMC3006418.
    12. Burnham KJ, Arai TJ, Dubowitz DJ, Henderson AC, Holverda S, Buxton RB, Prisk GK, Hopkins SR. Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans. J Appl Physiol (1985). 2009 Nov; 107(5):1559-68. PMID: 19745192; PMCID: PMC2777793.
    13. Theilmann RJ, Arai TJ, Samiee A, Dubowitz DJ, Hopkins SR, Buxton RB, Prisk GK. Quantitative MRI measurement of lung density must account for the change in T(2) (*) with lung inflation. J Magn Reson Imaging. 2009 Sep; 30(3):527-34. PMID: 19630079; PMCID: PMC3354915.
    14. Dubowitz DJ, Dyer EA, Theilmann RJ, Buxton RB, Hopkins SR. Early brain swelling in acute hypoxia. J Appl Physiol (1985). 2009 Jul; 107(1):244-52. PMID: 19423837; PMCID: PMC2711789.
    15. Arai TJ, Henderson AC, Dubowitz DJ, Levin DL, Friedman PJ, Buxton RB, Prisk GK, Hopkins SR. Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans. J Appl Physiol (1985). 2009 Apr; 106(4):1057-64. PMID: 19057006; PMCID: PMC2698636.
    16. Dyer EA, Hopkins SR, Perthen JE, Buxton RB, Dubowitz DJ. Regional cerebral blood flow during acute hypoxia in individuals susceptible to acute mountain sickness. Respir Physiol Neurobiol. 2008 Feb 29; 160(3):267-76. PMID: 18088570; PMCID: PMC2387187.
    17. Leontiev O, Dubowitz DJ, Buxton RB. CBF/CMRO2 coupling measured with calibrated BOLD fMRI: sources of bias. Neuroimage. 2007 Jul 15; 36(4):1110-22. PMID: 17524665; PMCID: PMC2038985.
    18. Lindsey JD, Scadeng M, Dubowitz DJ, Crowston JG, Weinreb RN. Magnetic resonance imaging of the visual system in vivo: transsynaptic illumination of V1 and V2 visual cortex. Neuroimage. 2007 Feb 15; 34(4):1619-26. PMID: 17204432.
      View in: PubMed
    19. Scadeng M, Rossiter HB, Dubowitz DJ, Breen EC. High-resolution three-dimensional magnetic resonance imaging of mouse lung in situ. Invest Radiol. 2007 Jan; 42(1):50-7. PMID: 17213749.
      View in: PubMed
    20. Ridgway S, Houser D, Finneran J, Carder D, Keogh M, Van Bonn W, Smith C, Scadeng M, Dubowitz D, Mattrey R, Hoh C. Functional imaging of dolphin brain metabolism and blood flow. J Exp Biol. 2006 Aug; 209(Pt 15):2902-10. PMID: 16857874.
      View in: PubMed
    21. Liu TT, Behzadi Y, Restom K, Uludag K, Lu K, Buracas GT, Dubowitz DJ, Buxton RB. Caffeine alters the temporal dynamics of the visual BOLD response. Neuroimage. 2004 Dec; 23(4):1402-13. PMID: 15589104.
      View in: PubMed
    22. Uludag K, Dubowitz DJ, Yoder EJ, Restom K, Liu TT, Buxton RB. Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI. Neuroimage. 2004 Sep; 23(1):148-55. PMID: 15325361.
      View in: PubMed
    23. Buxton RB, Uludag K, Dubowitz DJ, Liu TT. Modeling the hemodynamic response to brain activation. Neuroimage. 2004; 23 Suppl 1:S220-33. PMID: 15501093.
      View in: PubMed
    24. Dubowitz DJ. Direct comparison of visual cortex activation in human and nonhuman primates using functional magnetic resonance imaging. Methods Enzymol. 2004; 385:102-34. PMID: 15130736.
      View in: PubMed
    25. Moats RA, Velan-Mullan S, Jacobs R, Gonzalez-Gomez I, Dubowitz DJ, Taga T, Khankaldyyan V, Schultz L, Fraser S, Nelson MD, Laug WE. Micro-MRI at 11.7 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging. 2003 Jul; 2(3):150-8. PMID: 14649058.
      View in: PubMed
    26. McDowell JE, Brown GG, Paulus M, Martinez A, Stewart SE, Dubowitz DJ, Braff DL. Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biol Psychiatry. 2002 Feb 01; 51(3):216-23. PMID: 11839364.
      View in: PubMed
    27. Ahrens ET, Dubowitz DJ. Peripheral somatosensory fMRI in mouse at 11.7 T. NMR Biomed. 2001 Aug; 14(5):318-24. PMID: 11477652.
      View in: PubMed
    28. Dubowitz DJ, Chen DY, Atkinson DJ, Scadeng M, Martinez A, Andersen MB, Andersen RA, Bradley WG. Direct comparison of visual cortex activation in human and non-human primates using functional magnetic resonance imaging. J Neurosci Methods. 2001 May 30; 107(1-2):71-80. PMID: 11389943.
      View in: PubMed
    29. Dubowitz DJ, Tyszka JM, Sewry CA, Moats RA, Scadeng M, Dubowitz V. High resolution magnetic resonance imaging of the brain in the dy/dy mouse with merosin-deficient congenital muscular dystrophy. Neuromuscul Disord. 2000 Jun; 10(4-5):292-8. PMID: 10838257.
      View in: PubMed
    30. Ross BD, Hoang TQ, Blüml S, Dubowitz D, Kopyov OV, Jacques DB, Lin A, Seymour K, Tan J. In vivo magnetic resonance spectroscopy of human fetal neural transplants. NMR Biomed. 1999 Jun; 12(4):221-36. PMID: 10421914.
      View in: PubMed
    31. Martínez A, Anllo-Vento L, Sereno MI, Frank LR, Buxton RB, Dubowitz DJ, Wong EC, Hinrichs H, Heinze HJ, Hillyard SA. Involvement of striate and extrastriate visual cortical areas in spatial attention. Nat Neurosci. 1999 Apr; 2(4):364-9. PMID: 10204544.
      View in: PubMed
    32. Dubowitz DJ, Chen DY, Atkinson DJ, Grieve KL, Gillikin B, Bradley WG, Andersen RA. Functional magnetic resonance imaging in macaque cortex. Neuroreport. 1998 Jul 13; 9(10):2213-8. PMID: 9694202.
      View in: PubMed
    33. Hoang TQ, Bluml S, Dubowitz DJ, Moats R, Kopyov O, Jacques D, Ross BD. Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases. Neurology. 1998 Apr; 50(4):1033-40. PMID: 9566391.
      View in: PubMed