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Jason Sicklick

Title(s)Associate Professor of Surgery, Surgery
SchoolHealth Sciences
Address9500 Gilman Drive #0987
La Jolla CA 92093
Phone858-822-6173
Emailjsicklick@ucsd.edu
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    Collapse Biography 
    Collapse Awards and Honors
    Castle Connolly 2012  - 2018Region’s Top Doctors
    Life Raft Group 2016GIST Clinician of the Year
    San Diego Magazine2016  - 2018San Diego’s Top Doctors
    James IV Association of Surgeons2018  - 2019James IV Traveling Fellowship
    Global Genes2018RARE Champion of Hope in Medical Care & Treatment Award

    Collapse Overview 
    Collapse Overview
    Research
    Gastrointestinal stromal tumors (GIST)
    I am interested in both the role of molecular signaling in the genesis of liver cancers and the study of gastrointestinal stromal tumors (GIST). Currently, my laboratory is investigating: 1) novel allosteric kinase inhibitors to target imatinib-resistant GIST; 2) the role of Hedgehog signaling in the development of GIST; 3) the genomics of wild-type (WT), lacking driver mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF-1); 4) the epidemiology of GIST; and 5) novel surgical approaches for GIST (e.g., laparo-endoscopic gastric surgery and intra-operative fluorescence labeling of tumors).

    Primary liver cancer (hepatocellular carcinoma, HCC)
    As a postdoctoral research fellow, my colleagues and I were the first to identify the way in which the Hedgehog signaling pathway regulates liver progenitors, hepatic stellate cells, and human hepatocellular carcinoma. This body of work has been presented at national and international meetings, as well as has been published in peer-reviewed journals. As Hedgehog inhibitors have entered the clinic, this work holds the potential for high impact and translation into clinical trials. We have moved our findings from the bench to the bedside. I am the principal investigator of an investigator-initiated trial titled, “Phase Ib Study of Single Agent Sonidegib, an Oral Hedgehog Inhibitor, as Second-Line Therapy in Patients with Advanced or Metastatic Hepatocellular Carcinoma and Child-Pugh A/B7 Cirrhosis (NCT02151864).” This is the first study of a Hedgehog inhibitor in humans with liver diseases.

    Personalized medicine
    As a clinician-scientist, I am always interested in translating my scientific findings into the clinical care of my patients. With the recent revolution of genomics, many genetic investigations have become technically and fiscally feasible. Our interest in linking genomics with personalized cancer care led to the initiation of a multi-disciplinary molecular tumor board at Moores Cancer Center at UC San Diego Health. In order to apply this approach more rigorously, Dr. Razelle Kurzrock and I are co-principal investigators on a genomic-driven clinical study of 225 patients titled, I-PREDICT (Investigation of Profile-Related Evidence Determining Individualized Cancer Therapy; NCT02534675).

    Profile
    Dr. Jason Sicklick is an assistant professor of Surgery at UC San Diego Health Moores Cancer Center. He is a board-certified general surgeon and surgical oncologist specializing in the treatment of hepatobiliary diseases and sarcomas, including gastrointestinal stromal tumors (GIST). He received his medical degree from the UCLA School of Medicine, he completed his general surgery residency at The Johns Hopkins Hospital, and he completed a fellowship in surgical oncology at Memorial Sloan-Kettering Cancer Center where he was the chief administrative fellow. He joined the Division of Surgical Oncology at Moores Cancer Center in 2010. Dr. Sicklick is an active member of the National Cancer Institute GIST Working Group, the National Comprehensive Cancer Network (NCCN) Hepatobiliary Committee, and the Transatlantic Atlantic Retroperitoneal Sarcoma Working Group. Dr. Sicklick is on the editorial board of Annals of Surgical Oncology, Journal of Gastrointestinal Surgery and Journal of Surgical Research. He is also a member of the numerous societies including the Society of Surgical Oncology, American Society of Clinical Oncology, the American College of Surgeons, American Association for Cancer Research, the Association of Academic Surgery, and the Society for University Surgeons.

    His clinical interests include the treatment of GIST, abdominal/retroperitoneal sarcomas, colorectal and neuroendocrine cancers that have metastasized to the liver, and primary liver tumors. Working with other members of Moores Cancer Center’s Gastrointestinal Cancer Unit and UC San Diego Liver Center, he employs a number of techniques including:
  • Minimally invasive gastric resections of GIST, including laparo-endoscopic resections in collaboration with our minimally invasive surgery team;

  • Organ-sparing sarcoma resections to remove abdominal and retroperitoneal tumors;

  • Parenchymal-sparing liver resections to remove smaller amounts of liver tissue and increase the safety of such operations;

  • Hepatic arterial infusion pump placement for delivery of chemotherapy directly to the liver through a surgically implanted device;

  • Microwave (thermal) ablation-the application of heat to kill tumors;

  • Systemic chemotherapy administered by our medical oncology team;

  • Portal vein embolization to increase the amount of liver remaining after surgical resection performed by our interventional radiology team;

  • Hepatic artery embolization-blockage of blood vessels supplying liver tumors performed by our interventional radiology team;

  • His translational and clinical research focus on molecular mechanisms of GIST and hepatocellular carcinoma, as well as precision medicine approaches to cancer therapy.

    Current Positions
    - Assistant Professor In-Residence, Division of Surgical Oncology, Department of Surgery
    - General Surgery Residency Associate Program Director, Department of Surgery, University of California, San Diego
    - Co-Director for Clinical Collection, Biorepository and Tissue Technology Shared Resource (BTTSR), Moores Cancer Center at UC San Diego Health

    Collapse Research 
    Collapse Research Activities and Funding
    Investigation of DNA Damaging Agents in GIST with Metabolic Dysfunction
    FDA R01FD006334Sep 10, 2019 - Jul 31, 2022
    Role: Principal Investigator
    Targeting Drug-Resistant Cancer Stem Cell Niches of Gastrointestinal Stromal Tumor
    NIH/NCI R01CA226803Jun 1, 2019 - May 31, 2024
    Role: Principal Investigator
    Defining the Germline Genomic Landscape of a Novel GIST Multi-tumor Syndrome
    NIH/NCI R21CA192072Mar 4, 2016 - Feb 28, 2018
    Role: Principal Investigator
    Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GIST
    NIH/NCI K08CA168999Sep 10, 2014 - Aug 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Real-world data from a molecular tumor board demonstrates improved outcomes with a precision N-of-One strategy. Nat Commun. 2020 10 02; 11(1):4965. Kato S, Kim KH, Lim HJ, Boichard A, Nikanjam M, Weihe E, Kuo DJ, Eskander RN, Goodman A, Galanina N, Fanta PT, Schwab RB, Shatsky R, Plaxe SC, Sharabi A, Stites E, Adashek JJ, Okamura R, Lee S, Lippman SM, Sicklick JK, Kurzrock R. PMID: 33009371.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Attrition of Patients on a Precision Oncology Trial: Analysis of the I-PREDICT Experience. Oncologist. 2020 Sep 19. Bohan SS, Sicklick JK, Kato SM, Okamura R, Miller VA, Leyland-Jones B, Lippman SM, Kurzrock R. PMID: 32949172.
      View in: PubMed   Mentions:    Fields:    
    3. Cost-effectiveness Analysis of Genetic Testing and Tailored First-Line Therapy for Patients With Metastatic Gastrointestinal Stromal Tumors. JAMA Netw Open. 2020 Sep 01; 3(9):e2013565. Banerjee S, Kumar A, Lopez N, Zhao B, Tang CM, Yebra M, Yoon H, Murphy JD, Sicklick JK. PMID: 32986105.
      View in: PubMed   Mentions:    Fields:    
    4. Guidelines for Management of Urgent Symptoms in Patients with Cholangiocarcinoma and Biliary Stents or Catheters using the Modified RAND/UCLA Delphi Process. Cancers (Basel). 2020 Aug 21; 12(9). Iyer RV, Acquisto SG, Bridgewater JA, Choti MA, Hong TS, Kis B, Mead PA, Parikh ND, Roberts LR, Roberts R, Salem R, Sicklick JK, Siegel RS, Whisenant JR, Cherepanov D, Broder MS, Valle JW. PMID: 32825784.
      View in: PubMed   Mentions:
    5. Letter responds to comment on "intention-to-treat analysis in precision oncology: A cautious interpretation". Eur J Cancer. 2020 Aug 21. Sicklick J, Kato S, Kurzrock R. PMID: 32839070.
      View in: PubMed   Mentions:    Fields:    
    6. Comprehensive genomic landscape and precision therapeutic approach in biliary tract cancers. Int J Cancer. 2020 Jul 23. Okamura R, Kurzrock R, Mallory RJ, Fanta PT, Burgoyne AM, Clary BM, Kato S, Sicklick JK. PMID: 32700810.
      View in: PubMed   Mentions: 1     Fields:    
    7. Moving gastrointestinal stromal tumours towards truly personalised precision therapy. Lancet Oncol. 2020 07; 21(7):865-867. Nguyen V, Banerjee S, Sicklick JK. PMID: 32615099.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Precision oncology: the intention-to-treat analysis fallacy. Eur J Cancer. 2020 Jul; 133:25-28. Sicklick JK, Kato S, Okamura R, Kurzrock R. PMID: 32422506.
      View in: PubMed   Mentions:    Fields:    
    9. Cryopreservation of Viable Human Tissues: Renewable Resource for Viable Tissue, Cell Lines, and Organoid Development. Biopreserv Biobank. 2020 Jun; 18(3):222-227. He A, Powell S, Kyle M, Rose M, Masmila E, Estrada V, Sicklick JK, Molinolo A, Kaushal S. PMID: 32302515.
      View in: PubMed   Mentions:    Fields:    
    10. Anti-KIT DNA Aptamer for Targeted Labeling of Gastrointestinal Stromal Tumor. Mol Cancer Ther. 2020 05; 19(5):1173-1182. Banerjee S, Yoon H, Yebra M, Tang CM, Gilardi M, Shankara Narayanan JS, White RR, Sicklick JK, Ray P. PMID: 32127469.
      View in: PubMed   Mentions:
    11. Using machine learning to construct nomograms for patients with metastatic colon cancer. Colorectal Dis. 2020 Aug; 22(8):914-922. Zhao B, Gabriel RA, Vaida F, Eisenstein S, Schnickel GT, Sicklick JK, Clary BM. PMID: 31991031.
      View in: PubMed   Mentions:    Fields:    
    12. ARID1A alterations function as a biomarker for longer progression-free survival after anti-PD-1/PD-L1 immunotherapy. J Immunother Cancer. 2020 Feb; 8(1). Okamura R, Kato S, Lee S, Jimenez RE, Sicklick JK, Kurzrock R. PMID: 32111729.
      View in: PubMed   Mentions: 2     Fields:    
    13. Prognostic implications of RAS alterations in diverse malignancies and impact of targeted therapies. Int J Cancer. 2020 Jun 15; 146(12):3450-3460. Kato S, Okamura R, Sicklick JK, Daniels GA, Hong DS, Goodman A, Weihe E, Lee S, Khalid N, Collier R, Mareboina M, Riviere P, Whitchurch TJ, Fanta PT, Lippman SM, Kurzrock R. PMID: 31782524.
      View in: PubMed   Mentions: 1     Fields:    
    14. Synchronous metastatic colon cancer and the importance of primary tumor laterality - A National Cancer Database analysis of right- versus left-sided colon cancer. Am J Surg. 2020 08; 220(2):408-414. Zhao B, Lopez NE, Eisenstein S, Schnickel GT, Sicklick JK, Ramamoorthy SL, Clary BM. PMID: 31864521.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics. Ann Oncol. 2019 10 01; 30(10):1675. Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R. PMID: 31408092.
      View in: PubMed   Mentions: 1     Fields:    
    16. Current management of succinate dehydrogenase-deficient gastrointestinal stromal tumors. Cancer Metastasis Rev. 2019 09; 38(3):525-535. Neppala P, Banerjee S, Fanta PT, Yerba M, Porras KA, Burgoyne AM, Sicklick JK. PMID: 31773431.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma. J Transl Med. 2019 07 30; 17(1):246. Banerjee S, Corless CL, Miettinen MM, Noh S, Ustoy R, Davis JL, Tang CM, Yebra M, Burgoyne AM, Sicklick JK. PMID: 31362756.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Frequent rectal gastrointestinal stromal tumor recurrences in the imatinib era: Retrospective analysis of an International Patient Registry. J Surg Oncol. 2019 Sep; 120(4):715-721. Stuart E, Banerjee S, de la Torre J, Wang Y, Scherzer N, Burgoyne AM, Parry L, Fanta PT, Ramamoorthy S, Sicklick JK. PMID: 31297829.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Features of synchronous versus metachronous metastasectomy in adrenal cortical carcinoma: Analysis from the US adrenocortical carcinoma database. Surgery. 2020 02; 167(2):352-357. Prendergast KM, Smith PM, Tran TB, Postlewait LM, Maithel SK, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Shirley LA, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Votanopoulos KI, Levine EA, Poultsides GA, Solórzano CC, Kiernan CM. PMID: 31272813.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study. Nat Med. 2019 05; 25(5):744-750. Sicklick JK, Kato S, Okamura R, Schwaederle M, Hahn ME, Williams CB, De P, Krie A, Piccioni DE, Miller VA, Ross JS, Benson A, Webster J, Stephens PJ, Lee JJ, Fanta PT, Lippman SM, Leyland-Jones B, Kurzrock R. PMID: 31011206.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCTClinical Trials
    21. MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. Oncogene. 2019 07; 38(28):5599-5611. Babicky ML, Harper MM, Chakedis J, Cazes A, Mose ES, Jaquish DV, French RP, Childers B, Alakus H, Schmid MC, Foubert P, Miyamoto J, Holman PJ, Walterscheid ZJ, Tang CM, Varki N, Sicklick JK, Messer K, Varner JA, Waltz SE, Lowy AM. PMID: 30967626.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Guidelines Insights: Hepatobiliary Cancers, Version 2.2019. J Natl Compr Canc Netw. 2019 04 01; 17(4):302-310. Benson AB, D'Angelica MI, Abbott DE, Abrams TA, Alberts SR, Anaya DA, Anders R, Are C, Brown D, Chang DT, Cloyd J, Covey AM, Hawkins W, Iyer R, Jacob R, Karachristos A, Kelley RK, Kim R, Palta M, Park JO, Sahai V, Schefter T, Sicklick JK, Singh G, Sohal D, Stein S, Tian GG, Vauthey JN, Venook AP, Hammond LJ, Darlow SD. PMID: 30959462.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    23. Gastric Plexiform Fibromyxoma. J Gastrointest Surg. 2019 09; 23(9):1936-1939. Banerjee S, de la Torre J, Burgoyne AM, Ponsford Tipps AM, Savides TJ, Sicklick JK. PMID: 30761468.
      View in: PubMed   Mentions:    Fields:    
    24. Cholecystectomy During the Third Trimester of Pregnancy: Proceed or Delay? J Am Coll Surg. 2019 04; 228(4):494-502.e1. Fong ZV, Pitt HA, Strasberg SM, Molina RL, Perez NP, Kelleher CM, Loehrer AP, Sicklick JK, Talamini MA, Lillemoe KD, Chang DC. PMID: 30769111.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Revisiting Epidermal Growth Factor Receptor (EGFR) Amplification as a Target for Anti-EGFR Therapy: Analysis of Cell-Free Circulating Tumor DNA in Patients With Advanced Malignancies. JCO Precis Oncol. 2019; 3. Kato S, Okamura R, Mareboina M, Lee S, Goodman A, Patel SP, Fanta PT, Schwab RB, Vu P, Raymond VM, Lanman RB, Sicklick JK, Lippman SM, Kurzrock R. PMID: 31058253.
      View in: PubMed   Mentions:
    26. Biomarkers of Bad Biology: Curse or a Blessing? Ann Surg Oncol. 2019 Feb; 26(2):318-320. Banerjee S, Sicklick JK. PMID: 30539488.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics. JCO Precis Oncol. 2018; 2018. Okamura R, Boichard A, Kato S, Sicklick JK, Bazhenova L, Kurzrock R. PMID: 30637364.
      View in: PubMed   Mentions:
    28. Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics. Ann Oncol. 2018 11 01; 29(11):2192-2199. Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R. PMID: 30219896.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    29. Analysis of Circulating Tumor DNA and Clinical Correlates in Patients with Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma. Clin Cancer Res. 2018 12 15; 24(24):6248-6256. Kato S, Okamura R, Baumgartner JM, Patel H, Leichman L, Kelly K, Sicklick JK, Fanta PT, Lippman SM, Kurzrock R. PMID: 30348637.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    30. The prognostic significance of adrenocortical carcinomas identified incidentally. J Surg Oncol. 2018 Dec; 118(7):1155-1162. Rossfeld KK, Maithel SK, Prescott J, Wang TS, Fields RC, Weber SM, Sicklick JK, Yopp AC, Duh QY, Solorzano CC, Votanopoulos KI, Hatzaras I, Poultsides GA, Shirley LA. PMID: 30332514.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. ASO Author Reflections: Towards Better Metrics for Judging Academic Productivity in Surgical Oncology. Ann Surg Oncol. 2018 12; 25(Suppl 3):620-621. Nguyen V, Sicklick JK. PMID: 30298329.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors. JAMA Oncol. 2018 09 01; 4(9):1237-1244. Goodman AM, Piccioni D, Kato S, Boichard A, Wang HY, Frampton G, Lippman SM, Connelly C, Fabrizio D, Miller V, Sicklick JK, Kurzrock R. PMID: 29902298.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    33. Tumor Symbiosis: Gastrointestinal Stromal Tumor as a Host for Primary Peritoneal Mesothelioma. J Gastrointest Surg. 2019 04; 23(4):879-881. de la Torre J, Banerjee S, Baumgartner J, Lin GY, Burgoyne AM, Kirane A, Sicklick J. PMID: 30132292.
      View in: PubMed   Mentions:    Fields:    
    34. Role of Additional Organ Resection in Adrenocortical Carcinoma: Analysis of 167 Patients from the U.S. Adrenocortical Carcinoma Database. Ann Surg Oncol. 2018 Aug; 25(8):2308-2315. Marincola Smith P, Kiernan CM, Tran TB, Postlewait LM, Maithel SK, Prescott J, Pawlik T, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay J, Shirley LA, Fields RC, Jin L, Weber S, Salem A, Sicklick J, Gad S, Yopp A, Mansour J, Duh QY, Seiser N, Votanopoulos K, Levine EA, Poultsides G, Solórzano CC. PMID: 29868977.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. The Use of Solicited Publishing by Academic Surgeons. Surgery. 2018 08; 164(2):212-218. Nguyen V, Marmor RA, Ramamoorthy SL, Costantini TW, Baumgartner JM, Berumen J, Jacobsen GR, Sicklick JK. PMID: 29724409.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Academic Surgical Oncologists' Productivity Correlates with Gender, Grant Funding, and Institutional NCI Comprehensive Cancer Center Affiliation. Ann Surg Oncol. 2018 Jul; 25(7):1852-1859. Nguyen V, Marmor RA, Ramamoorthy SL, Blair SL, Clary BM, Sicklick JK. PMID: 29600347.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. A Novel PRKAR1B-BRAF Fusion in Gastrointestinal Stromal Tumor Guides Adjuvant Treatment Decision-Making During Pregnancy. J Natl Compr Canc Netw. 2018 03; 16(3):238-242. Charo LM, Burgoyne AM, Fanta PT, Patel H, Chmielecki J, Sicklick JK, McHale MT. PMID: 29523662.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. Oncologist. 2018 05; 23(5):586-593. Ikeda S, Tsigelny IF, Skjevik ÅA, Kono Y, Mendler M, Kuo A, Sicklick JK, Heestand G, Banks KC, Talasaz A, Lanman RB, Lippman S, Kurzrock R. PMID: 29487225.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    39. Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus. Clin Cancer Res. 2018 04 15; 24(8):1881-1890. Schrock AB, Pavlick D, Klempner SJ, Chung JH, Forcier B, Welsh A, Young L, Leyland-Jones B, Bordoni R, Carvajal RD, Chao J, Kurzrock R, Sicklick JK, Ross JS, Stephens PJ, Devoe C, Braiteh F, Ali SM, Miller VA. PMID: 29363525.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    40. Diminished Survival in Patients with Bile Leak and Ductal Injury: Management Strategy and Outcomes. J Am Coll Surg. 2018 04; 226(4):568-576.e1. Fong ZV, Pitt HA, Strasberg SM, Loehrer AP, Sicklick JK, Talamini MA, Lillemoe KD, Chang DC. PMID: 29307612.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J. 2018 03; 32(3):1170-1183. Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA. PMID: 29092903.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Nonuterine Lipoleiomyoma. Am Surg. 2017 Dec 01; 83(12):e474-475. Bommakanti K, Valasek MA, Sicklick JK. PMID: 29336739.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. A Novel T-Stage Classification System for Adrenocortical Carcinoma: Proposal from the US Adrenocortical Carcinoma Study Group. Ann Surg Oncol. 2018 Feb; 25(2):520-527. Poorman CE, Ethun CG, Postlewait LM, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solórzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK. PMID: 29164414.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. Duodenal-Jejunal Flexure GI Stromal Tumor Frequently Heralds Somatic NF1 and Notch Pathway Mutations. JCO Precis Oncol. 2017; 2017. Burgoyne AM, De Siena M, Alkhuziem M, Tang CM, Medina B, Fanta PT, Belinsky MG, von Mehren M, Thorson JA, Madlensky L, Bowler T, D'Angelo F, Stupack DG, Harismendy O, DeMatteo RP, Sicklick JK. PMID: 29938249.
      View in: PubMed   Mentions:
    45. SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors. J Gastrointest Surg. 2018 01; 22(1):32-42. Norton JA, Kim T, Kim J, McCarter MD, Kelly KJ, Wong J, Sicklick JK. PMID: 28808875.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance. Clin Cancer Res. 2017 Nov 01; 23(21):6733-6743. Bannon AE, Kent J, Forquer I, Town A, Klug LR, McCann K, Beadling C, Harismendy O, Sicklick JK, Corless C, Shinde U, Heinrich MC. PMID: 28724664.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    47. Blood Transfusion and Survival for Resected Adrenocortical Carcinoma: A Study from the United States Adrenocortical Carcinoma Group. Am Surg. 2017 Jul 01; 83(7):761-768. Poorman CE, Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK. PMID: 28738949.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    48. Molecular Pathways: Targeting the Microenvironment of Liver Metastases. Clin Cancer Res. 2017 Nov 01; 23(21):6390-6399. Milette S, Sicklick JK, Lowy AM, Brodt P. PMID: 28615370.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    49. Surgical Management of Adolescents and Young Adults With Gastrointestinal Stromal Tumors: A US Population-Based Analysis. JAMA Surg. 2017 05 01; 152(5):443-451. Fero KE, Coe TM, Fanta PT, Tang CM, Murphy JD, Sicklick JK. PMID: 28114506.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    50. The Call of "The Wild"-Type GIST: It's Time for Domestication. J Natl Compr Canc Netw. 2017 05; 15(5):551-554. Alkhuziem M, Burgoyne AM, Fanta PT, Tang CM, Sicklick JK. PMID: 28476734.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    51. NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017. J Natl Compr Canc Netw. 2017 05; 15(5):563-573. Benson AB, D'Angelica MI, Abbott DE, Abrams TA, Alberts SR, Saenz DA, Are C, Brown DB, Chang DT, Covey AM, Hawkins W, Iyer R, Jacob R, Karachristos A, Kelley RK, Kim R, Palta M, Park JO, Sahai V, Schefter T, Schmidt C, Sicklick JK, Singh G, Sohal D, Stein S, Tian GG, Vauthey JN, Venook AP, Zhu AX, Hoffmann KG, Darlow S. PMID: 28476736.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    52. Curative Surgical Resection of Adrenocortical Carcinoma: Determining Long-term Outcome Based on Conditional Disease-free Probability. Ann Surg. 2017 01; 265(1):197-204. Kim Y, Margonis GA, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 28009746.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    53. FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. J Transl Med. 2016 12 14; 14(1):339. Shi E, Chmielecki J, Tang CM, Wang K, Heinrich MC, Kang G, Corless CL, Hong D, Fero KE, Murphy JD, Fanta PT, Ali SM, De Siena M, Burgoyne AM, Movva S, Madlensky L, Heestand GM, Trent JC, Kurzrock R, Morosini D, Ross JS, Harismendy O, Sicklick JK. PMID: 27974047.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    54. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. Oncotarget. 2016 Nov 29; 7(48):78226-78241. Tang CM, Lee TE, Syed SA, Burgoyne AM, Leonard SY, Gao F, Chan JC, Shi E, Chmielecki J, Morosini D, Wang K, Ross JS, Kendrick ML, Bardsley MR, Siena M, Mao J, Harismendy O, Ordog T, Sicklick JK. PMID: 27793025.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    55. Minimally Invasive Resection of Adrenocortical Carcinoma: a Multi-Institutional Study of 201 Patients. J Gastrointest Surg. 2017 02; 21(2):352-362. Lee CW, Salem AI, Schneider DF, Leverson GE, Tran TB, Poultsides GA, Postlewait LM, Maithel SK, Wang TS, Hatzaras I, Shenoy R, Phay JE, Shirley L, Fields RC, Jin LX, Pawlik TM, Prescott JD, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Weber SM. PMID: 27770290.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    56. Fluorescence-guided laparoscopic hepatectomy. Ann Laparosc Endosc Surg. 2016 Sep; 1. Lwin TM, Sicklick JK, Hoffinan RM, Bouvet M. PMID: 30175321.
      View in: PubMed   Mentions:
    57. Actual 10-year survivors following resection of adrenocortical carcinoma. J Surg Oncol. 2016 Dec; 114(8):971-976. Tran TB, Postlewait LM, Maithel SK, Prescott JD, Wang TS, Glenn J, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Hatzaras I, Shenoy R, Pawlik TM, Norton JA, Poultsides GA. PMID: 27633419.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    58. Clinical Score Predicting Long-Term Survival after Repeat Resection for Recurrent Adrenocortical Carcinoma. J Am Coll Surg. 2016 12; 223(6):794-803. Tran TB, Maithel SK, Pawlik TM, Wang TS, Hatzaras I, Phay JE, Fields RC, Weber SM, Sicklick JK, Yopp AC, Duh QY, Solorzano CC, Votanopoulos KI, Poultsides GA. PMID: 27618748.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    59. Lymphadenectomy for Adrenocortical Carcinoma: Is There a Therapeutic Benefit? Ann Surg Oncol. 2016 12; 23(Suppl 5):708-713. Gerry JM, Tran TB, Postlewait LM, Maithel SK, Prescott JD, Wang TS, Glenn JA, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Hatzaras I, Shenoy R, Pawlik TM, Norton JA, Poultsides GA. PMID: 27590329.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    60. Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma. . 2016 11; 15(11):2553-2562. Singh AR, Joshi S, Burgoyne AM, Sicklick JK, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. PMID: 27496136.
      View in: PubMed   Mentions:
    61. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. PMID: 27281208.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    62. Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design. Cancer Metastasis Rev. 2016 06; 35(2):263-75. Sicklick JK, Fanta PT, Shimabukuro K, Kurzrock R. PMID: 26857926.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    63. Nomograms to Predict Recurrence-Free and Overall Survival After Curative Resection of Adrenocortical Carcinoma. JAMA Surg. 2016 Apr; 151(4):365-73. Kim Y, Margonis GA, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem AI, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 26676603.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    64. Population-Based Epidemiology and Mortality of Small Malignant Gastrointestinal Stromal Tumors in the USA. J Gastrointest Surg. 2016 06; 20(6):1132-40. Coe TM, Fero KE, Fanta PT, Mallory RJ, Tang CM, Murphy JD, Sicklick JK. PMID: 27025710.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    65. Incidence of Perioperative Complications Following Resection of Adrenocortical Carcinoma and Its Association with Long-Term Survival. World J Surg. 2016 Mar; 40(3):706-714. Margonis GA, Amini N, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Moses LE, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 26546184.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    66. Porta Hepatis Mass. JAMA Surg. 2016 Feb; 151(2):187-8. Niemiec SM, Vinetz JM, Sicklick JK. PMID: 26630439.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    67. Outcomes after resection of cortisol-secreting adrenocortical carcinoma. Am J Surg. 2016 Jun; 211(6):1106-13. Margonis GA, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 26810939.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    68. Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group. J Am Coll Surg. 2016 Apr; 222(4):480-90. Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK. PMID: 26775162.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    69. Incidence and Risk Factors Associated with Readmission After Surgical Treatment for Adrenocortical Carcinoma. J Gastrointest Surg. 2015 Dec; 19(12):2154-61. Valero-Elizondo J, Kim Y, Prescott JD, Margonis GA, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 26286367.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    70. Adrenocortical Carcinoma: Impact of Surgical Margin Status on Long-Term Outcomes. Ann Surg Oncol. 2016 Jan; 23(1):134-41. Margonis GA, Kim Y, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 26286195.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    71. Curative Resection of Adrenocortical Carcinoma: Rates and Patterns of Postoperative Recurrence. Ann Surg Oncol. 2016 Jan; 23(1):126-33. Amini N, Margonis GA, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 26282907.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    72. Neutrophil-lymphocyte and platelet-lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma. J Surg Oncol. 2015 Aug; 112(2):164-72. Bagante F, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick JK, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. PMID: 26234285.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    73. Increased risk of additional cancers among patients with gastrointestinal stromal tumors: A population-based study. Cancer. 2015 Sep 01; 121(17):2960-7. Murphy JD, Ma GL, Baumgartner JM, Madlensky L, Burgoyne AM, Tang CM, Martinez ME, Sicklick JK. PMID: 25930983.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    74. Small bowel volvulus in the adult populace of the United States: results from a population-based study. Am J Surg. 2015 Aug; 210(2):201-210.e2. Coe TM, Chang DC, Sicklick JK. PMID: 26002189.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    75. Diagnostic Accuracy of Preoperative Gadoxetic Acid-enhanced 3-T MR Imaging for Malignant Liver Lesions by Using Ex Vivo MR Imaging-matched Pathologic Findings as the Reference Standard. Radiology. 2015 Sep; 276(3):775-86. Costa EA, Cunha GM, Smorodinsky E, Cruite I, Tang A, Marks RM, Clark L, Wolfson T, Gamst A, Sicklick JK, Hemming A, Peterson MR, Middleton MS, Sirlin CB. PMID: 25875972.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    76. Platelet-Derived Growth Factor Receptor-a Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1. Gastroenterology. 2015 Aug; 149(2):420-32.e16. Hayashi Y, Bardsley MR, Toyomasu Y, Milosavljevic S, Gajdos GB, Choi KM, Reid-Lombardo KM, Kendrick ML, Bingener-Casey J, Tang CM, Sicklick JK, Gibbons SJ, Farrugia G, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Ramachandran A, Ordog T. PMID: 25865047.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    77. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. PMID: 25681274.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    78. Single-incision laparoscopic surgery through an ostomy site: a natural approach by an unnatural orifice. Surg Laparosc Endosc Percutan Tech. 2015 Feb; 25(1):74-8. Lopez NE, Peterson CY, Ramamoorthy SL, McLemore EC, Sedrak MF, Lowy AM, Horgan S, Talamini MA, Sicklick JK. PMID: 24743670.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    79. Laparo-endoscopic transgastric resection of gastric submucosal tumors. Surg Endosc. 2015 Aug; 29(8):2149-57. Barajas-Gamboa JS, Acosta G, Savides TJ, Sicklick JK, Fehmi SM, Coker AM, Green S, Broderick R, Nino DF, Harnsberger CR, Berducci MA, Sandler BJ, Talamini MA, Jacobsen GR, Horgan S. PMID: 25303921.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    80. Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):298-302. Ma GL, Murphy JD, Martinez ME, Sicklick JK. PMID: 25277795.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    81. Rapidly progressive subcutaneous metastases from gallbladder cancer: insight into a rare presentation in gastrointestinal malignancies. J Gastrointest Oncol. 2014 Aug; 5(4):E58-64. Heavey SF, Roeland EJ, Tipps AM, Datnow B, Sicklick JK. PMID: 25083307.
      View in: PubMed   Mentions:
    82. Pelvic mass after prostatectomy. Pseudosarcomatous fibromyxoid tumor. JAMA Surg. 2014 Jul; 149(7):741-2. Grigorian A, Ponsford Tipps AM, Derweesh IH, Boles SG, Sicklick JK. PMID: 24871499.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    83. Gastrointestinal stromal tumors in the setting of multiple tumor syndromes. Curr Opin Oncol. 2014 Jul; 26(4):408-14. Burgoyne AM, Somaiah N, Sicklick JK. PMID: 24840526.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    84. Long-term health-related quality of life after iatrogenic bile duct injury repair. J Am Coll Surg. 2014 Nov; 219(5):923-32.e10. Ejaz A, Spolverato G, Kim Y, Dodson R, Sicklick JK, Pitt HA, Lillemoe KD, Cameron JL, Pawlik TM. PMID: 25127511.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    85. International surgical residency electives: a collaborative effort from trainees to surgeons working in low- and middle-income countries. J Surg Educ. 2014 Sep-Oct; 71(5):694-700. Grigorian A, Sicklick JK, Kingham TP. PMID: 24776855.
      View in: PubMed   Mentions:    Fields:    
    86. In vivo imatinib sensitivity in a patient with GI stromal tumor bearing a PDGFRA deletion DIM842-844. J Clin Oncol. 2015 Mar 10; 33(8):e41-4. Fanta PT, Sicklick JK, Betz BL, Peterson MR. PMID: 24638008.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    87. Improved perioperative outcomes with minimally invasive distal pancreatectomy: results from a population-based analysis. JAMA Surg. 2014 Mar; 149(3):237-43. Tran Cao HS, Lopez N, Chang DC, Lowy AM, Bouvet M, Baumgartner JM, Talamini MA, Sicklick JK. PMID: 24402232.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    88. Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor. J Transl Med. 2014 Feb 10; 12:41. Sicklick JK, Leonard SY, Babicky ML, Tang CM, Mose ES, French RP, Jaquish DV, Hoh CK, Peterson M, Schwab R, Lowy AM. PMID: 24507750.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    89. The glypican 3 hepatocellular carcinoma marker regulates human hepatic stellate cells via Hedgehog signaling. J Surg Res. 2014 Apr; 187(2):377-85. Magistri P, Leonard SY, Tang CM, Chan JC, Lee TE, Sicklick JK. PMID: 24439425.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    90. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene. 2014 Nov 13; 33(46):5370-8. Rajurkar M, Huang H, Cotton JL, Brooks JK, Sicklick J, McMahon AP, Mao J. PMID: 24276242.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    91. In vivo fluorescence imaging of gastrointestinal stromal tumors using fluorophore-conjugated anti-KIT antibody. Ann Surg Oncol. 2013 Dec; 20 Suppl 3:S693-700. Metildi CA, Tang CM, Kaushal S, Leonard SY, Magistri P, Tran Cao HS, Hoffman RM, Bouvet M, Sicklick JK. PMID: 23943029.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    92. Optimizing surgical and imatinib therapy for the treatment of gastrointestinal stromal tumors. J Gastrointest Surg. 2013 Nov; 17(11):1997-2006. Sicklick JK, Lopez NE. PMID: 23775094.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    93. Management of abdominal malignancies: updates from the International Association of Surgeons, Gastroenterologists and Oncologists. Expert Rev Anticancer Ther. 2013 Apr; 13(4):395-7. Bouvet M, Sicklick JK. PMID: 23560834.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    94. Resection of the liver and inferior vena cava for hepatic malignancy. J Am Coll Surg. 2013 Jul; 217(1):115-24; discussion 124-5. Hemming AW, Mekeel KL, Zendejas I, Kim RD, Sicklick JK, Reed AI. PMID: 23376028.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    95. Have we hit an invisible barrier for preventing postoperative urinary tract infections? Arch Surg. 2012 Oct; 147(10):953-4. Sicklick JK. PMID: 23070410.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    96. Unusual imaging profile of a solitary splenic lymphangioma. Acta Radiol Short Rep. 2012; 1(8). Eghtedari M, Sicklick J, Kono Y, Peterson MR, Santillan CS. PMID: 23986850.
      View in: PubMed   Mentions:
    97. Correcting the misnomers of epithelial-mesenchymal relations. J Surg Res. 2013 Jun 01; 182(1):36-9. Sicklick JK. PMID: 22480829.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    98. Gastric cancer. Curr Probl Cancer. 2011 May-Jun; 35(3):97-127. Lawson JD, Sicklick JK, Fanta PT. PMID: 21635986.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    99. Randomized clinical trials in gastrointestinal stromal tumors. Surg Oncol Clin N Am. 2010 Jan; 19(1):101-13. Learn PA, Sicklick JK, DeMatteo RP. PMID: 19914562.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    100. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1093-106. Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, Yang L, Sudan DL, Sicklick JK, Michelotti GA, Rojkind M, Diehl AM. PMID: 19815628.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    101. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Lab Invest. 2007 Dec; 87(12):1227-39. Fleig SV, Choi SS, Yang L, Jung Y, Omenetti A, VanDongen HM, Huang J, Sicklick JK, Diehl AM. PMID: 17952094.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    102. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol. 2008 Jan; 48(1):98-106. Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM. PMID: 18022723.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    103. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest. 2007 May; 87(5):499-514. Omenetti A, Yang L, Li YX, McCall SJ, Jung Y, Sicklick JK, Huang J, Choi S, Suzuki A, Diehl AM. PMID: 17334411.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    104. Image of the month. Incarcerated sigmoid volvulus in a right inguinal hernia. Arch Surg. 2007 Feb; 142(2):199-200. Sicklick JK, Weiss CR, Ahuja N. PMID: 17309972.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    105. Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling. Lab Invest. 2007 Mar; 87(3):231-40. Li YX, Yang HT, Zdanowicz M, Sicklick JK, Qi Y, Camp TJ, Diehl AM. PMID: 17237799.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    106. Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology. 2006 Nov; 44(5):1267-77. Choi SS, Sicklick JK, Ma Q, Yang L, Huang J, Qi Y, Chen W, Li YX, Goldschmidt-Clermont PJ, Diehl AM. PMID: 17058265.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    107. Interleukin-15 increases hepatic regenerative activity. J Hepatol. 2006 Sep; 45(3):410-8. Suzuki A, McCall S, Choi SS, Sicklick JK, Huang J, Qi Y, Zdanowicz M, Camp T, Li YX, Diehl AM. PMID: 16781000.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    108. Evidence for epithelial-mesenchymal transitions in adult liver cells. Am J Physiol Gastrointest Liver Physiol. 2006 Oct; 291(4):G575-83. Sicklick JK, Choi SS, Bustamante M, McCall SJ, Pérez EH, Huang J, Li YX, Rojkind M, Diehl AM. PMID: 16710052.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    109. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis. 2006 Apr; 27(4):748-57. Sicklick JK, Li YX, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P, Ludlow JW, Owzar K, Chen W, Torbenson MS, Diehl AM. PMID: 16339184.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    110. Controversies in the surgical management of cholangiocarcinoma and gallbladder cancer. Semin Oncol. 2005 Dec; 32(6 Suppl 9):S112-7. Sicklick JK, Choti MA. PMID: 16399447.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    111. Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G859-70. Sicklick JK, Li YX, Melhem A, Schmelzer E, Zdanowicz M, Huang J, Caballero M, Fair JH, Ludlow JW, McClelland RE, Reid LM, Diehl AM. PMID: 16322088.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    112. Role for hedgehog signaling in hepatic stellate cell activation and viability. Lab Invest. 2005 Nov; 85(11):1368-80. Sicklick JK, Li YX, Choi SS, Qi Y, Chen W, Bustamante M, Huang J, Zdanowicz M, Camp T, Torbenson MS, Rojkind M, Diehl AM. PMID: 16170335.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    113. Surgical management of bile duct injuries sustained during laparoscopic cholecystectomy: perioperative results in 200 patients. Ann Surg. 2005 May; 241(5):786-92; discussion 793-5. Sicklick JK, Camp MS, Lillemoe KD, Melton GB, Yeo CJ, Campbell KA, Talamini MA, Pitt HA, Coleman J, Sauter PA, Cameron JL. PMID: 15849514.
      View in: PubMed   Mentions: 112     Fields:    Translation:Humans
    114. Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. Hum Pathol. 2005 Apr; 36(4):341-7. Kannangai R, Diehl AM, Sicklick J, Rojkind M, Thomas D, Torbenson M. PMID: 15891994.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    115. Azygous vein to right atrium bypass graft in a patient with idiopathic fibrosing mediastinitis and symptomatic superior and inferior vena cava obstructions. J Vasc Surg. 2002 Nov; 36(5):1071-5. Kakkis JL, Sicklick JK, Gomes A, Cohen B, Quiñones-Baldrich WJ. PMID: 12422122.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    116. Carotid endarterectomy with normal findings from a completion study: Is there need for early duplex scan? J Vasc Surg. 2001 May; 33(5):963-7. Pross C, Shortsleeve CM, Baker JD, Sicklick JK, Farooq MM, Moore WS, Quiñones-Baldrich WJ, Ahn SS, Gelabert HA, Freischlag JA. PMID: 11331835.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    117. Protein kinase C activation downregulates the expression and function of the basolateral Na+/K+/2Cl(-) cotransporter. J Cell Physiol. 1999 Dec; 181(3):489-98. Farokhzad OC, Sagar GD, Mun EC, Sicklick JK, Lotz M, Smith JA, Song JC, O'Brien TC, Sharma CP, Kinane TB, Hodin RA, Matthews JB. PMID: 10528235.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    118. Effects of bryostatin 1, a novel anticancer agent, on intestinal transport and barrier function: role of protein kinase C. Surgery. 1998 Aug; 124(2):380-6; discussion 386-7. Farokhzad OC, Mun EC, Sicklick JK, Smith JA, Matthews JB. PMID: 9706162.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    119. Osmotic regulation of intestinal epithelial Na(+)-K(+)-Cl- cotransport: role of Cl- and F-actin. Am J Physiol. 1998 03; 274(3):C697-706. Matthews JB, Smith JA, Mun EC, Sicklick JK. PMID: 9530101.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells