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Jason Sicklick

TitleAssociate Professor of Surgery
InstitutionUniversity of California San Diego
DepartmentSurgery
Address9500 Gilman Drive #0987
La Jolla CA 92093
Phone858-822-6173
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    Collapse Biography 
    Collapse Awards and Honors
    2016Life Raft Group GIST Clinician of the Year

    Collapse Overview 
    Collapse Overview
    Research
    Gastrointestinal stromal tumors (GIST)
    I am interested in both the role of molecular signaling in the genesis of liver cancers and the study of gastrointestinal stromal tumors (GIST). Currently, my laboratory is investigating: 1) novel allosteric kinase inhibitors to target imatinib-resistant GIST; 2) the role of Hedgehog signaling in the development of GIST; 3) the genomics of wild-type (WT), lacking driver mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF-1); 4) the epidemiology of GIST; and 5) novel surgical approaches for GIST (e.g., laparo-endoscopic gastric surgery and intra-operative fluorescence labeling of tumors).

    Primary liver cancer (hepatocellular carcinoma, HCC)
    As a postdoctoral research fellow, my colleagues and I were the first to identify the way in which the Hedgehog signaling pathway regulates liver progenitors, hepatic stellate cells, and human hepatocellular carcinoma. This body of work has been presented at national and international meetings, as well as has been published in peer-reviewed journals. As Hedgehog inhibitors have entered the clinic, this work holds the potential for high impact and translation into clinical trials. We have moved our findings from the bench to the bedside. I am the principal investigator of an investigator-initiated trial titled, “Phase Ib Study of Single Agent Sonidegib, an Oral Hedgehog Inhibitor, as Second-Line Therapy in Patients with Advanced or Metastatic Hepatocellular Carcinoma and Child-Pugh A/B7 Cirrhosis (NCT02151864).” This is the first study of a Hedgehog inhibitor in humans with liver diseases.

    Personalized medicine
    As a clinician-scientist, I am always interested in translating my scientific findings into the clinical care of my patients. With the recent revolution of genomics, many genetic investigations have become technically and fiscally feasible. Our interest in linking genomics with personalized cancer care led to the initiation of a multi-disciplinary molecular tumor board at Moores Cancer Center at UC San Diego Health. In order to apply this approach more rigorously, Dr. Razelle Kurzrock and I are co-principal investigators on a genomic-driven clinical study of 225 patients titled, I-PREDICT (Investigation of Profile-Related Evidence Determining Individualized Cancer Therapy; NCT02534675).

    Profile
    Dr. Jason Sicklick is an assistant professor of Surgery at UC San Diego Health Moores Cancer Center. He is a board-certified general surgeon and surgical oncologist specializing in the treatment of hepatobiliary diseases and sarcomas, including gastrointestinal stromal tumors (GIST). He received his medical degree from the UCLA School of Medicine, he completed his general surgery residency at The Johns Hopkins Hospital, and he completed a fellowship in surgical oncology at Memorial Sloan-Kettering Cancer Center where he was the chief administrative fellow. He joined the Division of Surgical Oncology at Moores Cancer Center in 2010. Dr. Sicklick is an active member of the National Cancer Institute GIST Working Group, the National Comprehensive Cancer Network (NCCN) Hepatobiliary Committee, and the Transatlantic Atlantic Retroperitoneal Sarcoma Working Group. Dr. Sicklick is on the editorial board of Annals of Surgical Oncology, Journal of Gastrointestinal Surgery and Journal of Surgical Research. He is also a member of the numerous societies including the Society of Surgical Oncology, American Society of Clinical Oncology, the American College of Surgeons, American Association for Cancer Research, the Association of Academic Surgery, and the Society for University Surgeons.

    His clinical interests include the treatment of GIST, abdominal/retroperitoneal sarcomas, colorectal and neuroendocrine cancers that have metastasized to the liver, and primary liver tumors. Working with other members of Moores Cancer Center’s Gastrointestinal Cancer Unit and UC San Diego Liver Center, he employs a number of techniques including:
  • Minimally invasive gastric resections of GIST, including laparo-endoscopic resections in collaboration with our minimally invasive surgery team;

  • Organ-sparing sarcoma resections to remove abdominal and retroperitoneal tumors;

  • Parenchymal-sparing liver resections to remove smaller amounts of liver tissue and increase the safety of such operations;

  • Hepatic arterial infusion pump placement for delivery of chemotherapy directly to the liver through a surgically implanted device;

  • Microwave (thermal) ablation-the application of heat to kill tumors;

  • Systemic chemotherapy administered by our medical oncology team;

  • Portal vein embolization to increase the amount of liver remaining after surgical resection performed by our interventional radiology team;

  • Hepatic artery embolization-blockage of blood vessels supplying liver tumors performed by our interventional radiology team;

  • His translational and clinical research focus on molecular mechanisms of GIST and hepatocellular carcinoma, as well as precision medicine approaches to cancer therapy.

    Current Positions
    - Assistant Professor In-Residence, Division of Surgical Oncology, Department of Surgery
    - General Surgery Residency Associate Program Director, Department of Surgery, University of California, San Diego
    - Co-Director for Clinical Collection, Biorepository and Tissue Technology Shared Resource (BTTSR), Moores Cancer Center at UC San Diego Health


    Collapse Research 
    Collapse Research Activities and Funding
    Defining the Germline Genomic Landscape of a Novel GIST Multi-tumor Syndrome
    NIH/NCI R21CA192072Mar 4, 2016 - Feb 28, 2018
    Role: Principal Investigator
    Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GIST
    NIH/NCI K08CA168999Sep 10, 2014 - Aug 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Goodman AM, Piccioni D, Kato S, Boichard A, Wang HY, Frampton G, Lippman SM, Connelly C, Fabrizio D, Miller V, Sicklick J, Kurzrock R. Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors. JAMA Oncol. 2018 Jun 14. PMID: 29902298.
      View in: PubMed
    2. Marincola Smith P, Kiernan CM, Tran TB, Postlewait LM, Maithel SK, Prescott J, Pawlik T, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay J, Shirley LA, Fields RC, Jin L, Weber S, Salem A, Sicklick J, Gad S, Yopp A, Mansour J, Duh QY, Seiser N, Votanopoulos K, Levine EA, Poultsides G, Solórzano CC. Role of Additional Organ Resection in Adrenocortical Carcinoma: Analysis of 167 Patients from the U.S. Adrenocortical Carcinoma Database. Ann Surg Oncol. 2018 Jun 04. PMID: 29868977.
      View in: PubMed
    3. Nguyen V, Marmor RA, Ramamoorthy SL, Costantini TW, Baumgartner JM, Berumen J, Jacobsen GR, Sicklick J. The Use of Solicited Publishing by Academic Surgeons. Surgery. 2018 Apr 30. PMID: 29724409.
      View in: PubMed
    4. Nguyen V, Marmor RA, Ramamoorthy SL, Blair SL, Clary BM, Sicklick J. Academic Surgical Oncologists' Productivity Correlates with Gender, Grant Funding, and Institutional NCI Comprehensive Cancer Center Affiliation. Ann Surg Oncol. 2018 Mar 29. PMID: 29600347.
      View in: PubMed
    5. Charo LM, Burgoyne AM, Fanta PT, Patel H, Chmielecki J, Sicklick J, McHale MT. A Novel PRKAR1B-BRAF Fusion in Gastrointestinal Stromal Tumor Guides Adjuvant Treatment Decision-Making During Pregnancy. J Natl Compr Canc Netw. 2018 Mar; 16(3):238-242. PMID: 29523662.
      View in: PubMed
    6. Ikeda S, Tsigelny IF, Skjevik ÅA, Kono Y, Mendler M, Kuo A, Sicklick J, Heestand G, Banks KC, Talasaz A, Lanman RB, Lippman S, Kurzrock R. Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. Oncologist. 2018 May; 23(5):586-593. PMID: 29487225.
      View in: PubMed
    7. Schrock AB, Pavlick D, Klempner SJ, Chung JH, Forcier B, Welsh A, Young L, Leyland-Jones B, Bordoni R, Carvajal RD, Chao J, Kurzrock R, Sicklick J, Ross JS, Stephens PJ, Devoe C, Braiteh F, Ali SM, Miller VA. Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus. Clin Cancer Res. 2018 Apr 15; 24(8):1881-1890. PMID: 29363525.
      View in: PubMed
    8. Fong ZV, Pitt HA, Strasberg SM, Loehrer AP, Sicklick J, Talamini MA, Lillemoe KD, Chang DC. Diminished Survival in Patients with Bile Leak and Ductal Injury: Management Strategy and Outcomes. J Am Coll Surg. 2018 Apr; 226(4):568-576.e1. PMID: 29307612.
      View in: PubMed
    9. Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J. 2018 Mar; 32(3):1170-1183. PMID: 29092903.
      View in: PubMed
    10. Bommakanti K, Valasek MA, Sicklick J. Nonuterine Lipoleiomyoma. Am Surg. 2017 12 01; 83(12):e474-475. PMID: 29336739.
      View in: PubMed
    11. Poorman CE, Ethun CG, Postlewait LM, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solórzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK. A Novel T-Stage Classification System for Adrenocortical Carcinoma: Proposal from the US Adrenocortical Carcinoma Study Group. Ann Surg Oncol. 2018 Feb; 25(2):520-527. PMID: 29164414.
      View in: PubMed
    12. Norton JA, Kim T, Kim J, McCarter MD, Kelly KJ, Wong J, Sicklick J. SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors. J Gastrointest Surg. 2018 Jan; 22(1):32-42. PMID: 28808875.
      View in: PubMed
    13. Bannon AE, Kent J, Forquer I, Town A, Klug LR, McCann K, Beadling C, Harismendy O, Sicklick J, Corless C, Shinde U, Heinrich MC. Biochemical, Molecular, and Clinical Characterization of Succinate Dehydrogenase Subunit A Variants of Unknown Significance. Clin Cancer Res. 2017 Nov 01; 23(21):6733-6743. PMID: 28724664.
      View in: PubMed
    14. Poorman CE, Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK. Blood Transfusion and Survival for Resected Adrenocortical Carcinoma: A Study from the United States Adrenocortical Carcinoma Group. Am Surg. 2017 Jul 01; 83(7):761-768. PMID: 28738949.
      View in: PubMed
    15. Milette S, Sicklick J, Lowy AM, Brodt P. Molecular Pathways: Targeting the Microenvironment of Liver Metastases. Clin Cancer Res. 2017 Nov 01; 23(21):6390-6399. PMID: 28615370.
      View in: PubMed
    16. Fero KE, Coe TM, Fanta PT, Tang CM, Murphy JD, Sicklick J. Surgical Management of Adolescents and Young Adults With Gastrointestinal Stromal Tumors: A US Population-Based Analysis. JAMA Surg. 2017 May 01; 152(5):443-451. PMID: 28114506.
      View in: PubMed
    17. Alkhuziem M, Burgoyne AM, Fanta PT, Tang CM, Sicklick J. The Call of "The Wild"-Type GIST: It's Time for Domestication. J Natl Compr Canc Netw. 2017 05; 15(5):551-554. PMID: 28476734.
      View in: PubMed
    18. Benson AB, D'Angelica MI, Abbott DE, Abrams TA, Alberts SR, Saenz DA, Are C, Brown DB, Chang DT, Covey AM, Hawkins W, Iyer R, Jacob R, Karachristos A, Kelley RK, Kim R, Palta M, Park JO, Sahai V, Schefter T, Schmidt C, Sicklick J, Singh G, Sohal D, Stein S, Tian GG, Vauthey JN, Venook AP, Zhu AX, Hoffmann KG, Darlow S. NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017. J Natl Compr Canc Netw. 2017 05; 15(5):563-573. PMID: 28476736.
      View in: PubMed
    19. Kim Y, Margonis GA, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Curative Surgical Resection of Adrenocortical Carcinoma: Determining Long-term Outcome Based on Conditional Disease-free Probability. Ann Surg. 2017 01; 265(1):197-204. PMID: 28009746.
      View in: PubMed
    20. Shi E, Chmielecki J, Tang CM, Wang K, Heinrich MC, Kang G, Corless CL, Hong D, Fero KE, Murphy JD, Fanta PT, Ali SM, De Siena M, Burgoyne AM, Movva S, Madlensky L, Heestand GM, Trent JC, Kurzrock R, Morosini D, Ross JS, Harismendy O, Sicklick J. FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. J Transl Med. 2016 12 14; 14(1):339. PMID: 27974047.
      View in: PubMed
    21. Tang CM, Lee TE, Syed SA, Burgoyne AM, Leonard SY, Gao F, Chan JC, Shi E, Chmielecki J, Morosini D, Wang K, Ross JS, Kendrick ML, Bardsley MR, Siena M, Mao J, Harismendy O, Ordog T, Sicklick J. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. Oncotarget. 2016 Nov 29; 7(48):78226-78241. PMID: 27793025.
      View in: PubMed
    22. Lee CW, Salem AI, Schneider DF, Leverson GE, Tran TB, Poultsides GA, Postlewait LM, Maithel SK, Wang TS, Hatzaras I, Shenoy R, Phay JE, Shirley L, Fields RC, Jin LX, Pawlik TM, Prescott JD, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Weber SM. Minimally Invasive Resection of Adrenocortical Carcinoma: a Multi-Institutional Study of 201 Patients. J Gastrointest Surg. 2017 02; 21(2):352-362. PMID: 27770290.
      View in: PubMed
    23. Tran TB, Postlewait LM, Maithel SK, Prescott JD, Wang TS, Glenn J, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Hatzaras I, Shenoy R, Pawlik TM, Norton JA, Poultsides GA. Actual 10-year survivors following resection of adrenocortical carcinoma. J Surg Oncol. 2016 Dec; 114(8):971-976. PMID: 27633419.
      View in: PubMed
    24. Tran TB, Maithel SK, Pawlik TM, Wang TS, Hatzaras I, Phay JE, Fields RC, Weber SM, Sicklick J, Yopp AC, Duh QY, Solorzano CC, Votanopoulos KI, Poultsides GA. Clinical Score Predicting Long-Term Survival after Repeat Resection for Recurrent Adrenocortical Carcinoma. J Am Coll Surg. 2016 Dec; 223(6):794-803. PMID: 27618748.
      View in: PubMed
    25. Gerry JM, Tran TB, Postlewait LM, Maithel SK, Prescott JD, Wang TS, Glenn JA, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Hatzaras I, Shenoy R, Pawlik TM, Norton JA, Poultsides GA. Lymphadenectomy for Adrenocortical Carcinoma: Is There a Therapeutic Benefit? Ann Surg Oncol. 2016 Dec; 23(Suppl 5):708-713. PMID: 27590329.
      View in: PubMed
    26. Singh AR, Joshi S, Burgoyne AM, Sicklick J, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma. Mol Cancer Ther. 2016 11; 15(11):2553-2562. PMID: 27496136.
      View in: PubMed
    27. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. PMID: 27281208; PMCID: PMC4998062 [Available on 12/16/16].
    28. Sicklick J, Fanta PT, Shimabukuro K, Kurzrock R. Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design. Cancer Metastasis Rev. 2016 06; 35(2):263-75. PMID: 26857926; PMCID: PMC4912391 [Available on 06/01/17].
    29. Kim Y, Margonis GA, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem AI, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Nomograms to Predict Recurrence-Free and Overall Survival After Curative Resection of Adrenocortical Carcinoma. JAMA Surg. 2016 Apr; 151(4):365-73. PMID: 26676603; PMCID: PMC4967352.
    30. Coe TM, Fero KE, Fanta PT, Mallory RJ, Tang CM, Murphy JD, Sicklick J. Population-Based Epidemiology and Mortality of Small Malignant Gastrointestinal Stromal Tumors in the USA. J Gastrointest Surg. 2016 06; 20(6):1132-40. PMID: 27025710; PMCID: PMC4880518 [Available on 06/01/17].
    31. Margonis GA, Amini N, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Moses LE, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Incidence of Perioperative Complications Following Resection of Adrenocortical Carcinoma and Its Association with Long-Term Survival. World J Surg. 2016 Mar; 40(3):706-714. PMID: 26546184; PMCID: PMC4957940.
    32. Niemiec SM, Vinetz JM, Sicklick J. Porta Hepatis Mass. JAMA Surg. 2016 Feb; 151(2):187-8. PMID: 26630439; PMCID: PMC4955387.
    33. Margonis GA, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Outcomes after resection of cortisol-secreting adrenocortical carcinoma. Am J Surg. 2016 Jun; 211(6):1106-13. PMID: 26810939; PMCID: PMC4957943.
    34. Postlewait LM, Ethun CG, Tran TB, Prescott JD, Pawlik TM, Wang TS, Glenn J, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Staley CA, Poultsides GA, Maithel SK. Outcomes of Adjuvant Mitotane after Resection of Adrenocortical Carcinoma: A 13-Institution Study by the US Adrenocortical Carcinoma Group. J Am Coll Surg. 2016 Apr; 222(4):480-90. PMID: 26775162; PMCID: PMC4957938.
    35. Valero-Elizondo J, Kim Y, Prescott JD, Margonis GA, Tran TB, Postlewait LM, Maithel SK, Wang TS, Glenn JA, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Incidence and Risk Factors Associated with Readmission After Surgical Treatment for Adrenocortical Carcinoma. J Gastrointest Surg. 2015 Dec; 19(12):2154-61. PMID: 26286367; PMCID: PMC4951184.
    36. Margonis GA, Kim Y, Prescott JD, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Adrenocortical Carcinoma: Impact of Surgical Margin Status on Long-Term Outcomes. Ann Surg Oncol. 2016 Jan; 23(1):134-41. PMID: 26286195; PMCID: PMC4955567.
    37. Amini N, Margonis GA, Kim Y, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Curative Resection of Adrenocortical Carcinoma: Rates and Patterns of Postoperative Recurrence. Ann Surg Oncol. 2016 Jan; 23(1):126-33. PMID: 26282907; PMCID: PMC4962540.
    38. Bagante F, Tran TB, Postlewait LM, Maithel SK, Wang TS, Evans DB, Hatzaras I, Shenoy R, Phay JE, Keplinger K, Fields RC, Jin LX, Weber SM, Salem A, Sicklick J, Gad S, Yopp AC, Mansour JC, Duh QY, Seiser N, Solorzano CC, Kiernan CM, Votanopoulos KI, Levine EA, Poultsides GA, Pawlik TM. Neutrophil-lymphocyte and platelet-lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma. J Surg Oncol. 2015 Aug; 112(2):164-72. PMID: 26234285; PMCID: PMC4962528.
    39. Murphy JD, Ma GL, Baumgartner JM, Madlensky L, Burgoyne AM, Tang CM, Martinez ME, Sicklick J. Increased risk of additional cancers among patients with gastrointestinal stromal tumors: A population-based study. Cancer. 2015 Sep 01; 121(17):2960-7. PMID: 25930983; PMCID: PMC4545693.
    40. Coe TM, Chang DC, Sicklick J. Small bowel volvulus in the adult populace of the United States: results from a population-based study. Am J Surg. 2015 Aug; 210(2):201-210.e2. PMID: 26002189; PMCID: PMC4475430.
    41. Costa EA, Cunha GM, Smorodinsky E, Cruite I, Tang A, Marks RM, Clark L, Wolfson T, Gamst A, Sicklick J, Hemming A, Peterson MR, Middleton MS, Sirlin CB. Diagnostic Accuracy of Preoperative Gadoxetic Acid-enhanced 3-T MR Imaging for Malignant Liver Lesions by Using Ex Vivo MR Imaging-matched Pathologic Findings as the Reference Standard. Radiology. 2015 Sep; 276(3):775-86. PMID: 25875972; PMCID: PMC4962530.
    42. Hayashi Y, Bardsley MR, Toyomasu Y, Milosavljevic S, Gajdos GB, Choi KM, Reid-Lombardo KM, Kendrick ML, Bingener-Casey J, Tang CM, Sicklick J, Gibbons SJ, Farrugia G, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Ramachandran A, Ordog T. Platelet-Derived Growth Factor Receptor-a Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1. Gastroenterology. 2015 Aug; 149(2):420-32.e16. PMID: 25865047; PMCID: PMC4516576.
    43. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick J, Lowy AM, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. PMID: 25681274; PMCID: PMC4458508.
    44. Lopez NE, Peterson CY, Ramamoorthy SL, McLemore EC, Sedrak MF, Lowy AM, Horgan S, Talamini MA, Sicklick J. Single-incision laparoscopic surgery through an ostomy site: a natural approach by an unnatural orifice. Surg Laparosc Endosc Percutan Tech. 2015 Feb; 25(1):74-8. PMID: 24743670.
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    45. Barajas-Gamboa JS, Acosta G, Savides TJ, Sicklick J, Fehmi SM, Coker AM, Green S, Broderick R, Nino DF, Harnsberger CR, Berducci MA, Sandler BJ, Talamini MA, Jacobsen GR, Horgan S. Laparo-endoscopic transgastric resection of gastric submucosal tumors. Surg Endosc. 2015 Aug; 29(8):2149-57. PMID: 25303921; PMCID: PMC4951182.
    46. Ma GL, Murphy JD, Martinez ME, Sicklick J. Epidemiology of gastrointestinal stromal tumors in the era of histology codes: results of a population-based study. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):298-302. PMID: 25277795; PMCID: PMC4294949.
    47. Heavey SF, Roeland EJ, Tipps AM, Datnow B, Sicklick J. Rapidly progressive subcutaneous metastases from gallbladder cancer: insight into a rare presentation in gastrointestinal malignancies. J Gastrointest Oncol. 2014 Aug; 5(4):E58-64. PMID: 25083307; PMCID: PMC4110491.
    48. Grigorian A, Ponsford Tipps AM, Derweesh IH, Boles SG, Sicklick J. Pelvic mass after prostatectomy. Pseudosarcomatous fibromyxoid tumor. JAMA Surg. 2014 Jul; 149(7):741-2. PMID: 24871499.
      View in: PubMed
    49. Burgoyne AM, Somaiah N, Sicklick J. Gastrointestinal stromal tumors in the setting of multiple tumor syndromes. Curr Opin Oncol. 2014 Jul; 26(4):408-14. PMID: 24840526.
      View in: PubMed
    50. Ejaz A, Spolverato G, Kim Y, Dodson R, Sicklick J, Pitt HA, Lillemoe KD, Cameron JL, Pawlik TM. Long-term health-related quality of life after iatrogenic bile duct injury repair. J Am Coll Surg. 2014 Nov; 219(5):923-32.e10. PMID: 25127511.
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    51. Grigorian A, Sicklick J, Kingham TP. International surgical residency electives: a collaborative effort from trainees to surgeons working in low- and middle-income countries. J Surg Educ. 2014 Sep-Oct; 71(5):694-700. PMID: 24776855.
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    52. Fanta PT, Sicklick J, Betz BL, Peterson MR. In vivo imatinib sensitivity in a patient with GI stromal tumor bearing a PDGFRA deletion DIM842-844. J Clin Oncol. 2015 Mar 10; 33(8):e41-4. PMID: 24638008; PMCID: PMC4884274.
    53. Tran Cao HS, Lopez N, Chang DC, Lowy AM, Bouvet M, Baumgartner JM, Talamini MA, Sicklick J. Improved perioperative outcomes with minimally invasive distal pancreatectomy: results from a population-based analysis. JAMA Surg. 2014 Mar; 149(3):237-43. PMID: 24402232; PMCID: PMC4383084.
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    55. Magistri P, Leonard SY, Tang CM, Chan JC, Lee TE, Sicklick J. The glypican 3 hepatocellular carcinoma marker regulates human hepatic stellate cells via Hedgehog signaling. J Surg Res. 2014 Apr; 187(2):377-85. PMID: 24439425.
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    56. Metildi CA, Tang CM, Kaushal S, Leonard SY, Magistri P, Tran Cao HS, Hoffman RM, Bouvet M, Sicklick J. In vivo fluorescence imaging of gastrointestinal stromal tumors using fluorophore-conjugated anti-KIT antibody. Ann Surg Oncol. 2013 Dec; 20 Suppl 3:S693-700. PMID: 23943029; PMCID: PMC4127988.
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    58. Bouvet M, Sicklick J. Management of abdominal malignancies: updates from the International Association of Surgeons, Gastroenterologists and Oncologists. Expert Rev Anticancer Ther. 2013 Apr; 13(4):395-7. PMID: 23560834.
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    59. Hemming AW, Mekeel KL, Zendejas I, Kim RD, Sicklick J, Reed AI. Resection of the liver and inferior vena cava for hepatic malignancy. J Am Coll Surg. 2013 Jul; 217(1):115-24; discussion 124-5. PMID: 23376028.
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    60. Sicklick J. Have we hit an invisible barrier for preventing postoperative urinary tract infections? Arch Surg. 2012 Oct; 147(10):953-4. PMID: 23070410.
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    63. Lawson JD, Sicklick J, Fanta PT. Gastric cancer. Curr Probl Cancer. 2011 May-Jun; 35(3):97-127. PMID: 21635986.
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    64. Learn PA, Sicklick J, DeMatteo RP. Randomized clinical trials in gastrointestinal stromal tumors. Surg Oncol Clin N Am. 2010 Jan; 19(1):101-13. PMID: 19914562; PMCID: PMC3164338.
    65. Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, Yang L, Sudan DL, Sicklick J, Michelotti GA, Rojkind M, Diehl AM. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1093-106. PMID: 19815628; PMCID: PMC2850083.
    66. Fleig SV, Choi SS, Yang L, Jung Y, Omenetti A, VanDongen HM, Huang J, Sicklick J, Diehl AM. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Lab Invest. 2007 Dec; 87(12):1227-39. PMID: 17952094.
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    67. Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick J, Li YX, Diehl AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol. 2008 Jan; 48(1):98-106. PMID: 18022723; PMCID: PMC2196213.
    68. Omenetti A, Yang L, Li YX, McCall SJ, Jung Y, Sicklick J, Huang J, Choi S, Suzuki A, Diehl AM. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest. 2007 May; 87(5):499-514. PMID: 17334411.
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    69. Sicklick J, Weiss CR, Ahuja N. Image of the month. Incarcerated sigmoid volvulus in a right inguinal hernia. Arch Surg. 2007 Feb; 142(2):199-200. PMID: 17309972.
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    70. Li YX, Yang HT, Zdanowicz M, Sicklick J, Qi Y, Camp TJ, Diehl AM. Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling. Lab Invest. 2007 Mar; 87(3):231-40. PMID: 17237799.
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    71. Choi SS, Sicklick J, Ma Q, Yang L, Huang J, Qi Y, Chen W, Li YX, Goldschmidt-Clermont PJ, Diehl AM. Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology. 2006 Nov; 44(5):1267-77. PMID: 17058265.
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    72. Suzuki A, McCall S, Choi SS, Sicklick J, Huang J, Qi Y, Zdanowicz M, Camp T, Li YX, Diehl AM. Interleukin-15 increases hepatic regenerative activity. J Hepatol. 2006 Sep; 45(3):410-8. PMID: 16781000.
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    73. Sicklick J, Choi SS, Bustamante M, McCall SJ, Pérez EH, Huang J, Li YX, Rojkind M, Diehl AM. Evidence for epithelial-mesenchymal transitions in adult liver cells. Am J Physiol Gastrointest Liver Physiol. 2006 Oct; 291(4):G575-83. PMID: 16710052.
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    74. Sicklick J, Li YX, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P, Ludlow JW, Owzar K, Chen W, Torbenson MS, Diehl AM. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis. 2006 Apr; 27(4):748-57. PMID: 16339184.
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    75. Sicklick J, Li YX, Melhem A, Schmelzer E, Zdanowicz M, Huang J, Caballero M, Fair JH, Ludlow JW, McClelland RE, Reid LM, Diehl AM. Hedgehog signaling maintains resident hepatic progenitors throughout life. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G859-70. PMID: 16322088.
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    76. Sicklick J, Choti MA. Controversies in the surgical management of cholangiocarcinoma and gallbladder cancer. Semin Oncol. 2005 Dec; 32(6 Suppl 9):S112-7. PMID: 16399447.
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    77. Sicklick J, Li YX, Choi SS, Qi Y, Chen W, Bustamante M, Huang J, Zdanowicz M, Camp T, Torbenson MS, Rojkind M, Diehl AM. Role for hedgehog signaling in hepatic stellate cell activation and viability. Lab Invest. 2005 Nov; 85(11):1368-80. PMID: 16170335.
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    78. Sicklick J, Camp MS, Lillemoe KD, Melton GB, Yeo CJ, Campbell KA, Talamini MA, Pitt HA, Coleman J, Sauter PA, Cameron JL. Surgical management of bile duct injuries sustained during laparoscopic cholecystectomy: perioperative results in 200 patients. Ann Surg. 2005 May; 241(5):786-92; discussion 793-5. PMID: 15849514; PMCID: PMC1357133.
    79. Kannangai R, Diehl AM, Sicklick J, Rojkind M, Thomas D, Torbenson M. Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. Hum Pathol. 2005 Apr; 36(4):341-7. PMID: 15891994.
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    80. Kakkis JL, Sicklick J, Gomes A, Cohen B, Quiñones-Baldrich WJ. Azygous vein to right atrium bypass graft in a patient with idiopathic fibrosing mediastinitis and symptomatic superior and inferior vena cava obstructions. J Vasc Surg. 2002 Nov; 36(5):1071-5. PMID: 12422122.
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