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    Ethan Bier

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0349
    CA La Jolla 92093
    Phone858-534-8792
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      Collapse Research 
      Collapse Research Activities and Funding
      Mutagenic chain reaction-facilitated immunotherapy
      NIH/NIAID R01AI131081Sep 9, 2016 - Aug 31, 2021
      Role: Principal Investigator
      The mutagenic chain reaction: a method for autocatalyic gene dissemination
      NIH/NIGMS R01GM117321Apr 1, 2016 - Mar 31, 2020
      Role: Principal Investigator
      Analyzing a novel mechanism of action of bacterial cAMP producing toxins
      NIH/NIAID R01AI110713Feb 1, 2014 - Jan 31, 2019
      Role: Principal Investigator
      The Molecular Genetics of Early Neurogenesis
      NIH/NINDS R56NS029870Aug 1, 2013 - Jul 31, 2014
      Role: Principal Investigator
      Analyzing Anthrox Toxins in Drosophila
      NIH/NIAID R01AI070654Dec 1, 2007 - Nov 30, 2013
      Role: Principal Investigator
      Analyzing Anthrax Toxins in Drosophilia
      NIH/NIAID R56AI070654Jul 1, 2006 - Aug 31, 2014
      Role: Principal Investigator
      Genetic Analysis of Bacterial Toxins in Drosophia
      NIH/NIAID R21AI060976Jun 1, 2004 - May 31, 2007
      Role: Principal Investigator
      Analysis of DPP and Toll Signalling
      NIH/FIC R03TW001329Jul 1, 2000 - Jul 31, 2008
      Role: Principal Investigator
      Analysis of Early Wing Vein Development in Drosophila
      NIH/NIGMS R01GM060585Jan 1, 2000 - Dec 31, 2007
      Role: Principal Investigator
      Molecular Genetics of Early Neurogenesis
      NIH/NINDS R01NS029870May 1, 1992 - Feb 29, 2012
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zúñiga EI, Krug RM, Oldstone MB, Bier E. Influenza NS1 directly modulates Hedgehog signaling during infection. PLoS Pathog. 2017 Aug; 13(8):e1006588. PMID: 28837667.
        View in: PubMed
      2. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. Rules of the road for insect gene drive research and testing. Nat Biotechnol. 2017 Aug 08; 35(8):716-718. PMID: 28787415.
        View in: PubMed
      3. Gantz VM, Bier E. The dawn of active genetics. Bioessays. 2016 Jan; 38(1):50-63. PMID: 26660392.
        View in: PubMed
      4. Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci U S A. 2015 Dec 8; 112(49):E6736-43. PMID: 26598698.
        View in: PubMed
      5. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. PMID: 26229113.
        View in: PubMed
      6. Bier E, De Robertis EM. EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning. Science. 2015 Jun 26; 348(6242):aaa5838. PMID: 26113727.
        View in: PubMed
      7. Gantz VM, Bier E. Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science. 2015 Apr 24; 348(6233):442-4. PMID: 25908821.
        View in: PubMed
      8. Bier E, Nizet V. Hedgehog: linking uracil to innate defense. Cell Host Microbe. 2015 Feb 11; 17(2):146-8. PMID: 25674980.
        View in: PubMed
      9. Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs Regulate msx Gene Expression in the Dorsal Neuroectoderm of Drosophila and Vertebrates by Distinct Mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. PMID: 25210771.
        View in: PubMed
      10. Guichard A, Nizet V, Bier E. RAB11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol. 2014 Aug 14; 12(9):624-34. PMID: 25118884.
        View in: PubMed
      11. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013 Sep 11; 14(3):294-305. PMID: 24034615.
        View in: PubMed
      12. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 5; 16(3):311-21. PMID: 22958918.
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      13. Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 2011 Nov; 7(11):e1002344. PMID: 22072978.
        View in: PubMed
      14. Bier E, Guichard A. Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech. 2012 Jan; 5(1):48-61. PMID: 21979942.
        View in: PubMed
      15. Guichard A, Nizet V, Bier E. New insights into the biological effects of anthrax toxins: linking cellular to organismal responses. Microbes Infect. 2012 Feb; 14(2):97-118. PMID: 21930233.
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      16. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 1; 360(1):230-40. PMID: 21920356.
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      17. Bier E. Evolution of development: diversified dorsoventral patterning. Curr Biol. 2011 Aug 9; 21(15):R591-4. PMID: 21820625.
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      18. Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell. 2011 Jul; 2(7):554-63. PMID: 21822800.
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      19. Do LH, Bier E. The Booly aliasing resource: a database of grouped biological identifiers. Bioinformation. 2011; 6(2):83-5. PMID: 21544171.
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      20. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010 Oct 14; 467(7317):854-8. PMID: 20944747.
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      21. Do LH, Esteves FF, Karten HJ, Bier E. Booly: a new data integration platform. BMC Bioinformatics. 2010; 11:513. PMID: 20942966.
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      22. Kang KH, Bier E. dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog. Dev Biol. 2010 Oct 1; 346(1):1-10. PMID: 20599894.
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      23. Lee JH, Bodmer R, Bier E, Karin M. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74. PMID: 20606249.
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      24. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 5; 327(5970):1223-8. PMID: 20203043.
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      25. Mizutani CM, Bier E. EvoD/Vo: the origins of BMP signalling in the neuroectoderm. Nat Rev Genet. 2008 Sep; 9(9):663-77. PMID: 18679435.
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      26. Bier E. Intriguing extracellular regulation of BMP signaling. Dev Cell. 2008 Aug; 15(2):176-7. PMID: 18694555.
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      27. Iyadurai SJ, Robinson JT, Ma L, He Y, Mische S, Li MG, Brown W, Guichard A, Bier E, Hays TS. Dynein and Star interact in EGFR signaling and ligand trafficking. J Cell Sci. 2008 Aug 15; 121(Pt 16):2643-51. PMID: 18653542.
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      28. Reiter LT, Do LH, Fischer MS, Hong NA, Bier E. Accentuate the negative: proteome comparisons using the negative proteome database. Fly (Austin). 2007 May-Jun; 1(3):164-71. PMID: 18820470.
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      29. Mizutani CM, Meyer N, Roelink H, Bier E. Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm. PLoS Biol. 2006 Oct; 4(10):e313. PMID: 16968133.
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      30. Bier E. Antioxidants put Parkinson flies back in the PINK. Proc Natl Acad Sci U S A. 2006 Sep 5; 103(36):13269-70. PMID: 16938856.
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      31. Reiter LT, Seagroves TN, Bowers M, Bier E. Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet. 2006 Sep 15; 15(18):2825-35. PMID: 16905559.
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      32. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9. PMID: 16455799.
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      33. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug; 233(4):1315-31. PMID: 15965977.
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      34. Mizutani CM, Nie Q, Wan FY, Zhang YT, Vilmos P, Sousa-Neves R, Bier E, Marsh JL, Lander AD. Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell. 2005 Jun; 8(6):915-24. PMID: 15935780.
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      35. Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet. 2005 Jan; 6(1):9-23. PMID: 15630418.
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      36. Bier E, Bodmer R. Drosophila, an emerging model for cardiac disease. Gene. 2004 Nov 10; 342(1):1-11. PMID: 15527959.
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      37. Kosman D, Mizutani CM, Lemons D, Cox WG, McGinnis W, Bier E. Multiplex detection of RNA expression in Drosophila embryos. Science. 2004 Aug 6; 305(5685):846. PMID: 15297669.
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      38. Cook O, Biehs B, Bier E. brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Development. 2004 May; 131(9):2113-24. PMID: 15073155.
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      39. Yu K, Kang KH, Heine P, Pyati U, Srinivasan S, Biehs B, Kimelman D, Bier E. Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein. Genetics. 2004 Mar; 166(3):1323-36. PMID: 15082551.
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      40. Araujo H, Negreiros E, Bier E. Integrins modulate Sog activity in the Drosophila wing. Development. 2003 Aug; 130(16):3851-64. PMID: 12835400.
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      41. Hériché JK, Ang D, Bier E, O'Farrell PH. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 4; 4:9. PMID: 12787468.
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      42. Lunde K, Trimble JL, Guichard A, Guss KA, Nauber U, Bier E. Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development. 2003 Jan; 130(2):235-48. PMID: 12466192.
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      43. Reiter LT, Bier E. Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert Opin Ther Targets. 2002 Jun; 6(3):387-99. PMID: 12223075.
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      44. Guichard A, Srinivasan S, Zimm G, Bier E. A screen for dominant mutations applied to components in the Drosophila EGF-R pathway. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3752-7. PMID: 11904431.
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      45. Srinivasan S, Rashka KE, Bier E. Creation of a Sog morphogen gradient in the Drosophila embryo. Dev Cell. 2002 Jan; 2(1):91-101. PMID: 11782317.
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      46. Chien S, Reiter LT, Bier E, Gribskov M. Homophila: human disease gene cognates in Drosophila. Nucleic Acids Res. 2002 Jan 1; 30(1):149-51. PMID: 11752278.
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      47. Reiter LT, Potocki L, Chien S, Gribskov M, Bier E. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 2001 Jun; 11(6):1114-25. PMID: 11381037.
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      48. Guichard A, Roark M, Ronshaugen M, Bier E. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev Biol. 2000 Oct 15; 226(2):255-66. PMID: 11023685.
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      49. Bier E. Drawing lines in the Drosophila wing: initiation of wing vein development. Curr Opin Genet Dev. 2000 Aug; 10(4):393-8. PMID: 10889058.
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      50. Araujo H, Bier E. sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo. Development. 2000 Aug; 127(16):3631-44. PMID: 10903186.
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      51. Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka KE, Kimelman D, O'Connor MB, Bier E. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development. 2000 May; 127(10):2143-54. PMID: 10769238.
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      52. Guichard A, Biehs B, Sturtevant MA, Wickline L, Chacko J, Howard K, Bier E. rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development. 1999 Jun; 126(12):2663-76. PMID: 10331978.
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      53. Lunde K, Biehs B, Nauber U, Bier E. The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development. 1998 Nov; 125(21):4145-54. PMID: 9753669.
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      54. Biehs B, Sturtevant MA, Bier E. Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development. 1998 Nov; 125(21):4245-57. PMID: 9753679.
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      55. Bier E. Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays. 1998 Mar; 20(3):189-94. PMID: 9631645.
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      56. Bier E. Anti-neural-inhibition: a conserved mechanism for neural induction. Cell. 1997 May 30; 89(5):681-4. PMID: 9182755.
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      57. Sturtevant MA, Biehs B, Marin E, Bier E. The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development. 1997 Jan; 124(1):21-32. PMID: 9006064.
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      58. Yu K, Sturtevant MA, Biehs B, François V, Padgett RW, Blackman RK, Bier E. The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. Development. 1996 Dec; 122(12):4033-44. PMID: 9012523.
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      59. Biehs B, François V, Bier E. The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev. 1996 Nov 15; 10(22):2922-34. PMID: 8918893.
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      60. Sturtevant MA, Roark M, O'Neill JW, Biehs B, Colley N, Bier E. The Drosophila rhomboid protein is concentrated in patches at the apical cell surface. Dev Biol. 1996 Mar 15; 174(2):298-309. PMID: 8631502.
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      61. Emery JF, Bier E. Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression. Development. 1995 Nov; 121(11):3549-60. PMID: 8582269.
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      62. Sturtevant MA, Bier E. Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development. 1995 Mar; 121(3):785-801. PMID: 7720583.
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      63. O'Neill JW, Bier E. Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques. 1994 Nov; 17(5):870, 874-5. PMID: 7840966.
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      64. Francois V, Solloway M, O'Neill JW, Emery J, Bier E. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev. 1994 Nov 1; 8(21):2602-16. PMID: 7958919.
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      65. Sturtevant MA, O'Neill JW, Bier E. Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Development. 1994 Sep; 120(9):2593-600. PMID: 7956834.
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      66. Noll R, Sturtevant MA, Gollapudi RR, Bier E. New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracy. Development. 1994 Aug; 120(8):2329-38. PMID: 7925033.
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      67. Ip YT, Levine M, Bier E. Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements. Development. 1994 Jan; 120(1):199-207. PMID: 8119127.
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      68. Sturtevant MA, Roark M, Bier E. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev. 1993 Jun; 7(6):961-73. PMID: 8504935.
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      69. Ip YT, Park RE, Kosman D, Bier E, Levine M. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev. 1992 Sep; 6(9):1728-39. PMID: 1325394.
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