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Ethan Bier

Title(s)Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Analysis of active genetic elements in germline and somatic cell lineages
    NIH R35GM158085Aug 1, 2025 - Jul 31, 2030
    Role: Principal Investigator
    Analysis of homolog-based CRISPR editing in somatic cells
    NIH R01GM144608Aug 15, 2022 - Jun 30, 2026
    Role: Principal Investigator
    Development of next-generation gene drive technologies for Anopheles population engineering
    NIH R01AI162911Jun 1, 2021 - May 31, 2026
    Role: Principal Investigator
    Mutagenic chain reaction-facilitated immunotherapy
    NIH R01AI131081Sep 9, 2016 - Aug 31, 2021
    Role: Principal Investigator
    The mutagenic chain reaction: a method for autocatalyic gene dissemination
    NIH R01GM117321Apr 1, 2016 - Mar 31, 2025
    Role: Principal Investigator
    Analyzing a novel mechanism of action of bacterial cAMP producing toxins
    NIH R01AI110713Feb 1, 2014 - Jan 31, 2020
    Role: Principal Investigator
    The Molecular Genetics of Early Neurogenesis
    NIH R56NS029870Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Analyzing Anthrox Toxins in Drosophila
    NIH R01AI070654Dec 1, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Analyzing Anthrax Toxins in Drosophilia
    NIH R56AI070654Jul 1, 2006 - Aug 31, 2015
    Role: Principal Investigator
    Genetic Analysis of Bacterial Toxins in Drosophia
    NIH R21AI060976Jun 1, 2004 - May 31, 2007
    Role: Principal Investigator
    Analysis of DPP and Toll Signalling
    NIH R03TW001329Jul 1, 2000 - Jul 31, 2008
    Role: Principal Investigator
    Analysis of Early Wing Vein Development in Drosophila
    NIH R01GM060585Jan 1, 2000 - Dec 31, 2007
    Role: Principal Investigator
    Molecular Genetics of Early Neurogenesis
    NIH R01NS029870May 1, 1992 - Feb 29, 2012
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A conjugal gene drive-like system efficiently suppresses antibiotic resistance in a bacterial population. NPJ Antimicrob Resist. 2026 Feb 02; 4(1):8. Kaduwal S, Stuart EC, Auradkar A, Washabaugh S, Meyer JR, Bier E. PMID: 41629533; PMCID: PMC12864801.
      View in: PubMed   Mentions:
    2. Anthrax ET activates Rac1 and RTK signaling to induce F-actin reorganization and endothelial permeability. iScience. 2025 Nov 21; 28(11):113682. Jain P, Guichard A, Moayeri M, Kaduwal S, Mel de Fontenay M, Rousseau I, Leppla SH, Bier E. PMID: 41158867; PMCID: PMC12555787.
      View in: PubMed   Mentions:
    3. Driving a protective allele of the mosquito FREP1 gene to combat malaria. Nature. 2025 09; 645(8081):746-754. Li Z, Dong Y, You L, Corder RM, Arzobal J, Yeun A, Yang L, Marshall JM, Dimopoulos G, Bier E. PMID: 40702179; PMCID: PMC12443604.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    4. A self-eliminating allelic-drive reverses insecticide resistance in Drosophila leaving no transgene in the population. Nat Commun. 2024 11 17; 15(1):9961. Auradkar A, Corder RM, Marshall JM, Bier E. PMID: 39551783; PMCID: PMC11570635.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    5. Author Correction: tgCRISPRi: efficient gene knock-down using truncated gRNAs and catalytically active Cas9. Nat Commun. 2024 Apr 12; 15(1):3183. Auradkar A, Guichard A, Kaduwal S, Sneider M, Bier E. PMID: 38609401; PMCID: PMC11015020.
      View in: PubMed   Mentions:    Fields:    
    6. Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control. CRISPR J. 2024 04; 7(2):88-99. Lima L, Berni M, Mota J, Bressan D, Julio A, Cavalcante R, Macias V, Li Z, Rasgon JL, Bier E, Araujo H. PMID: 38564197.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsPHPublic Health
    7. Developmental progression of DNA double-strand break repair deciphered by a single-allele resolution mutation classifier. Nat Commun. 2024 Mar 23; 15(1):2629. Li Z, You L, Hermann A, Bier E. PMID: 38521791; PMCID: PMC10960810.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    8. Development of an anti-Pfs230 monoclonal antibody as a Plasmodium falciparum gametocyte blocker. Res Sq. 2023 Dec 19. Cuccurullo EC, Dong Y, Simões ML, Dimopoulos G, Bier E. PMID: 38196646; PMCID: PMC10775378.
      View in: PubMed   Mentions:
    9. Conceptual risk assessment of mosquito population modification gene-drive systems to control malaria transmission: preliminary hazards list workshops. Front Bioeng Biotechnol. 2023; 11:1261123. Kormos A, Dimopoulos G, Bier E, Lanzaro GC, Marshall JM, James AA. PMID: 37965050; PMCID: PMC10641379.
      View in: PubMed   Mentions: 6  
    10. tgCRISPRi: efficient gene knock-down using truncated gRNAs and catalytically active Cas9. Nat Commun. 2023 09 11; 14(1):5587. Auradkar A, Guichard A, Kaduwal S, Sneider M, Bier E. PMID: 37696787; PMCID: PMC10495392.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Cell Rep. 2023 08 29; 42(8):112842. Guichard A, Lu S, Kanca O, Bressan D, Huang Y, Ma M, Sanz Juste S, Andrews JC, Jay KL, Sneider M, Schwartz R, Huang MC, Bei D, Pan H, Ma L, Lin WW, Auradkar A, Bhagwat P, Park S, Wan KH, Ohsako T, Takano-Shimizu T, Celniker SE, Wangler MF, Yamamoto S, Bellen HJ, Bier E. PMID: 37480566; PMCID: PMC10962759.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Genetic conversion of a split-drive into a full-drive element. Nat Commun. 2023 01 12; 14(1):191. Terradas G, Bennett JB, Li Z, Marshall JM, Bier E. PMID: 36635291; PMCID: PMC9837192.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    13. Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells. Sci Adv. 2022 07; 8(26):eabo0721. Roy S, Juste SS, Sneider M, Auradkar A, Klanseck C, Li Z, Julio AHF, Lopez del Amo V, Bier E, Guichard A. PMID: 35776792; PMCID: PMC10883370.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Active genetics comes alive: Exploring the broad applications of CRISPR-based selfish genetic elements (or gene-drives): Exploring the broad applications of CRISPR-based selfish genetic elements (or gene-drives). Bioessays. 2022 Aug; 44(8):e2100279. Gantz VM, Bier E. PMID: 35686327; PMCID: PMC9397133.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    15. Author Correction: Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly. BMC Biol. 2022 May 02; 20(1):96. Chakraborty M, Ramaiah A, Adolfi A, Halas P, Kaduskar B, Ngo LT, Jayaprasad S, Paul K, Whadgar S, Srinivasan S, Subramani S, Bier E, James AA, Emerson JJ. PMID: 35501892; PMCID: PMC9059397.
      View in: PubMed   Mentions: 4     Fields:    
    16. Ethical Considerations for Gene Drive: Challenges of Balancing Inclusion, Power and Perspectives. Front Bioeng Biotechnol. 2022; 10:826727. Kormos A, Lanzaro GC, Bier E, Santos V, Nazaré L, Pinto J, Aguiar Dos Santos A, James AA. PMID: 35127663; PMCID: PMC8814439.
      View in: PubMed   Mentions: 11  
    17. Reversing insecticide resistance with allelic-drive in Drosophila melanogaster. Nat Commun. 2022 01 12; 13(1):291. Kaduskar B, Kushwah RBS, Auradkar A, Guichard A, Li M, Bennett JB, Julio AHF, Marshall JM, Montell C, Bier E. PMID: 35022402; PMCID: PMC8755802.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    18. High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoes. G3 (Bethesda). 2022 01 04; 12(1). Terradas G, Hermann A, James AA, McGinnis W, Bier E. PMID: 34791161; PMCID: PMC8728002.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    19. Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline. PLoS Biol. 2021 Dec; 19(12):e3001478. Weitzel AJ, Grunwald HA, Weber C, Levina R, Gantz VM, Hedrick SM, Bier E, Cooper KL. PMID: 34941868; PMCID: PMC8699911.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    20. Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by full locus replacement. Sci Adv. 2021 Nov 12; 7(46):eabk1003. Auradkar A, Bulger EA, Devkota S, McGinnis W, Bier E. PMID: 34757777; PMCID: PMC8580299.
      View in: PubMed   Mentions: 3     Fields:    
    21. Gene drives gaining speed. Nat Rev Genet. 2022 Jan; 23(1):5-22. Bier E. PMID: 34363067; PMCID: PMC8344398.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    22. CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion. Nat Commun. 2021 05 11; 12(1):2625. Li Z, Marcel N, Devkota S, Auradkar A, Hedrick SM, Gantz VM, Bier E. PMID: 33976171; PMCID: PMC8113449.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. Driving to Safety: CRISPR-Based Genetic Approaches to Reducing Antibiotic Resistance. Trends Genet. 2021 08; 37(8):745-757. Bier E, Nizet V. PMID: 33745750.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Inherently confinable split-drive systems in Drosophila. Nat Commun. 2021 03 05; 12(1):1480. Terradas G, Buchman AB, Bennett JB, Shriner I, Marshall JM, Akbari OS, Bier E. PMID: 33674604; PMCID: PMC7935863.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    25. Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly. BMC Biol. 2021 02 10; 19(1):28. Chakraborty M, Ramaiah A, Adolfi A, Halas P, Kaduskar B, Ngo LT, Jayaprasad S, Paul K, Whadgar S, Srinivasan S, Subramani S, Bier E, James AA, Emerson JJ. PMID: 33568145; PMCID: PMC7876825.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsPHPublic Health
    26. Application of the Relationship-Based Model to Engagement for Field Trials of Genetically Engineered Malaria Vectors. Am J Trop Med Hyg. 2020 12 21; 104(3):805-811. Kormos A, Lanzaro GC, Bier E, Dimopoulos G, Marshall JM, Pinto J, Aguiar Dos Santos A, Bacar A, Sousa Pontes Sacramento Rompão H, James AA. PMID: 33350374; PMCID: PMC7941841.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsPHPublic Health
    27. Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi. Nat Commun. 2020 11 03; 11(1):5553. Adolfi A, Gantz VM, Jasinskiene N, Lee HF, Hwang K, Terradas G, Bulger EA, Ramaiah A, Bennett JB, Emerson JJ, Marshall JM, Bier E, James AA. PMID: 33144570; PMCID: PMC7609566.
      View in: PubMed   Mentions: 100     Fields:    Translation:Animals
    28. Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives. Mol Cell. 2020 Oct 15; 80(2):246-262.e4. Xu XS, Bulger EA, Gantz VM, Klanseck C, Heimler SR, Auradkar A, Bennett JB, Miller LA, Leahy S, Juste SS, Buchman A, Akbari OS, Marshall JM, Bier E. PMID: 32949493; PMCID: PMC10962758.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    29. Translating gene drive science to promote linguistic diversity in community and stakeholder engagement. Glob Public Health. 2020 10; 15(10):1551-1565. Cheung C, Gamez S, Carballar-Lejarazú R, Ferman V, Vásquez VN, Terradas G, Ishikawa J, Schairer CE, Bier E, Marshall JM, James AA, Akbari OS, Bloss CS. PMID: 32589115.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsPHPublic Health
    30. Assessment of a Split Homing Based Gene Drive for Efficient Knockout of Multiple Genes. G3 (Bethesda). 2020 Feb 06; 10(2):827-837. Kandul NP, Liu J, Buchman A, Gantz VM, Bier E, Akbari OS. PMID: 31882406; PMCID: PMC7003086.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    31. A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. iScience. 2020 Feb 21; 23(2):100865. Schwartz R, Guichard A, Franc NC, Roy S, Bier E. PMID: 32058973; PMCID: PMC7011083.
      View in: PubMed   Mentions: 4  
    32. A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment. Nat Commun. 2020 Jan 17; 11(1):352. López Del Amo V, Bishop AL, Sánchez C HM, Bennett JB, Feng X, Marshall JM, Bier E, Gantz VM. PMID: 31953404; PMCID: PMC6969112.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    33. Author Correction: Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature. 2020 01; 577(7792):E8. Grunwald HA, Gantz VM, Poplawski G, Xu XS, Bier E, Cooper KL. PMID: 31911657.
      View in: PubMed   Mentions: 1     Fields:    
    34. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Commun. 2019 Dec 16; 10(1):5726. Valderrama JA, Kulkarni SS, Nizet V, Bier E. PMID: 31844051; PMCID: PMC6915771.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    35. Efficient allelic-drive in Drosophila. Nat Commun. 2019 04 09; 10(1):1640. Guichard A, Haque T, Bobik M, Xu XS, Klanseck C, Kushwah RBS, Berni M, Kaduskar B, Gantz VM, Bier E. PMID: 30967548; PMCID: PMC6456580.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    36. Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature. 2019 Feb; 566(7742):105-109. Grunwald HA, Gantz VM, Poplawski G, Xu XS, Bier E, Cooper KL. PMID: 30675057; PMCID: PMC6367021.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    37. N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs. Development. 2018 11 19; 145(22). Negreiros E, Herszterg S, Kang KH, Câmara A, Dias WB, Carneiro K, Bier E, Todeschini AR, Araujo H. PMID: 30355725; PMCID: PMC6262792.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    38. Innate Immune Interactions between Bacillus anthracis and Host Neutrophils. Front Cell Infect Microbiol. 2018; 8:2. Liu JZ, Ali SR, Bier E, Nizet V. PMID: 29404280; PMCID: PMC5786542.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    39. Advances in Engineering the Fly Genome with the CRISPR-Cas System. Genetics. 2018 Jan; 208(1):1-18. Bier E, Harrison MM, O'Connor-Giles KM, Wildonger J. PMID: 29301946; PMCID: PMC5753851.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    40. CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity. Elife. 2017 12 23; 6. Xu XS, Gantz VM, Siomava N, Bier E. PMID: 29274230; PMCID: PMC5800851.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    41. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017 Sep; 13(9):e1006603. Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E. PMID: 28945820; PMCID: PMC5612732.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    42. Influenza NS1 directly modulates Hedgehog signaling during infection. PLoS Pathog. 2017 Aug; 13(8):e1006588. Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zúñiga EI, Krug RM, Oldstone MB, Bier E. PMID: 28837667; PMCID: PMC5587344.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    43. Rules of the road for insect gene drive research and testing. Nat Biotechnol. 2017 08 08; 35(8):716-718. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. PMID: 28787415; PMCID: PMC5831321.
      View in: PubMed   Mentions: 40     Fields:    
    44. The dawn of active genetics. Bioessays. 2016 Jan; 38(1):50-63. Gantz VM, Bier E. PMID: 26660392; PMCID: PMC5819344.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    45. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6736-43. Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA. PMID: 26598698; PMCID: PMC4679060.
      View in: PubMed   Mentions: 466     Fields:    Translation:AnimalsCellsPHPublic Health
    46. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. PMID: 26229113; PMCID: PMC4692367.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    47. EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning. Science. 2015 Jun 26; 348(6242):aaa5838. Bier E, De Robertis EM. PMID: 26113727.
      View in: PubMed   Mentions: 138     Fields:    Translation:Animals
    48. Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science. 2015 Apr 24; 348(6233):442-4. Gantz VM, Bier E. PMID: 25908821; PMCID: PMC4687737.
      View in: PubMed   Mentions: 250     Fields:    Translation:AnimalsCells
    49. Hedgehog: linking uracil to innate defense. Cell Host Microbe. 2015 Feb 11; 17(2):146-8. Bier E, Nizet V. PMID: 25674980.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    50. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. PMID: 25210771; PMCID: PMC4161316.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    51. RAB11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol. 2014 Sep; 12(9):624-34. Guichard A, Nizet V, Bier E. PMID: 25118884; PMCID: PMC4274738.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    52. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013 Sep 11; 14(3):294-305. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. PMID: 24034615; PMCID: PMC3786442.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    53. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. PMID: 22958918; PMCID: PMC3687365.
      View in: PubMed   Mentions: 164     Fields:    Translation:Animals
    54. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 2011 Nov; 7(11):e1002344. Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. PMID: 22072978; PMCID: PMC3207880.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    55. Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech. 2012 Jan; 5(1):48-61. Bier E, Guichard A. PMID: 21979942; PMCID: PMC3255543.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    56. New insights into the biological effects of anthrax toxins: linking cellular to organismal responses. Microbes Infect. 2012 Feb; 14(2):97-118. Guichard A, Nizet V, Bier E. PMID: 21930233; PMCID: PMC3743078.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    57. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 01; 360(1):230-40. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. PMID: 21920356; PMCID: PMC3661008.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    58. Evolution of development: diversified dorsoventral patterning. Curr Biol. 2011 Aug 09; 21(15):R591-4. Bier E. PMID: 21820625; PMCID: PMC3842600.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    59. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell. 2011 Jul; 2(7):554-63. Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. PMID: 21822800; PMCID: PMC3702159.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    60. The Booly aliasing resource: a database of grouped biological identifiers. Bioinformation. 2011 Mar 26; 6(2):83-5. Do LH, Bier E. PMID: 21544171; PMCID: PMC3082858.
      View in: PubMed   Mentions:
    61. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010 Oct 14; 467(7317):854-8. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. PMID: 20944747; PMCID: PMC5831355.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    62. Booly: a new data integration platform. BMC Bioinformatics. 2010 Oct 13; 11:513. Do LH, Esteves FF, Karten HJ, Bier E. PMID: 20942966; PMCID: PMC2970612.
      View in: PubMed   Mentions: 2     Fields:    
    63. dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog. Dev Biol. 2010 Oct 01; 346(1):1-10. Kang KH, Bier E. PMID: 20599894; PMCID: PMC2937060.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    64. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74. Lee JH, Bodmer R, Bier E, Karin M. PMID: 20606249; PMCID: PMC2919257.
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    65. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. PMID: 20203043; PMCID: PMC2866632.
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    66. EvoD/Vo: the origins of BMP signalling in the neuroectoderm. Nat Rev Genet. 2008 Sep; 9(9):663-77. Mizutani CM, Bier E. PMID: 18679435; PMCID: PMC2888941.
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    67. Intriguing extracellular regulation of BMP signaling. Dev Cell. 2008 Aug; 15(2):176-7. Bier E. PMID: 18694555.
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    68. Dynein and Star interact in EGFR signaling and ligand trafficking. J Cell Sci. 2008 Aug 15; 121(Pt 16):2643-51. Iyadurai SJ, Robinson JT, Ma L, He Y, Mische S, Li MG, Brown W, Guichard A, Bier E, Hays TS. PMID: 18653542; PMCID: PMC2633900.
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    69. Accentuate the negative: proteome comparisons using the negative proteome database. Fly (Austin). 2007 May-Jun; 1(3):164-71. Reiter LT, Do LH, Fischer MS, Hong NA, Bier E. PMID: 18820470.
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    70. Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm. PLoS Biol. 2006 Oct; 4(10):e313. Mizutani CM, Meyer N, Roelink H, Bier E. PMID: 16968133; PMCID: PMC1563485.
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    71. Antioxidants put Parkinson flies back in the PINK. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13269-70. Bier E. PMID: 16938856; PMCID: PMC1569152.
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    72. Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet. 2006 Sep 15; 15(18):2825-35. Reiter LT, Seagroves TN, Bowers M, Bier E. PMID: 16905559; PMCID: PMC3742451.
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    73. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. PMID: 16455799; PMCID: PMC1413899.
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    74. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug; 233(4):1315-31. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. PMID: 15965977.
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    75. Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell. 2005 Jun; 8(6):915-24. Mizutani CM, Nie Q, Wan FY, Zhang YT, Vilmos P, Sousa-Neves R, Bier E, Marsh JL, Lander AD. PMID: 15935780; PMCID: PMC1829168.
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    76. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet. 2005 Jan; 6(1):9-23. Bier E. PMID: 15630418.
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    77. Drosophila, an emerging model for cardiac disease. Gene. 2004 Nov 10; 342(1):1-11. Bier E, Bodmer R. PMID: 15527959.
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    78. Multiplex detection of RNA expression in Drosophila embryos. Science. 2004 Aug 06; 305(5685):846. Kosman D, Mizutani CM, Lemons D, Cox WG, McGinnis W, Bier E. PMID: 15297669.
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    79. brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Development. 2004 May; 131(9):2113-24. Cook O, Biehs B, Bier E. PMID: 15073155.
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    80. Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein. Genetics. 2004 Mar; 166(3):1323-36. Yu K, Kang KH, Heine P, Pyati U, Srinivasan S, Biehs B, Kimelman D, Bier E. PMID: 15082551; PMCID: PMC1470778.
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    81. Integrins modulate Sog activity in the Drosophila wing. Development. 2003 Aug; 130(16):3851-64. Araujo H, Negreiros E, Bier E. PMID: 12835400.
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    82. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 04; 4:9. Hériché JK, Ang D, Bier E, O'Farrell PH. PMID: 12787468; PMCID: PMC161817.
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    83. Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development. 2003 Jan; 130(2):235-48. Lunde K, Trimble JL, Guichard A, Guss KA, Nauber U, Bier E. PMID: 12466192.
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    84. Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert Opin Ther Targets. 2002 Jun; 6(3):387-99. Reiter LT, Bier E. PMID: 12223075.
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    85. A screen for dominant mutations applied to components in the Drosophila EGF-R pathway. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3752-7. Guichard A, Srinivasan S, Zimm G, Bier E. PMID: 11904431; PMCID: PMC122596.
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    86. Creation of a Sog morphogen gradient in the Drosophila embryo. Dev Cell. 2002 Jan; 2(1):91-101. Srinivasan S, Rashka KE, Bier E. PMID: 11782317.
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    87. Homophila: human disease gene cognates in Drosophila. Nucleic Acids Res. 2002 Jan 01; 30(1):149-51. Chien S, Reiter LT, Bier E, Gribskov M. PMID: 11752278; PMCID: PMC99119.
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    88. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 2001 Jun; 11(6):1114-25. Reiter LT, Potocki L, Chien S, Gribskov M, Bier E. PMID: 11381037; PMCID: PMC311089.
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    89. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev Biol. 2000 Oct 15; 226(2):255-66. Guichard A, Roark M, Ronshaugen M, Bier E. PMID: 11023685.
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    90. Drawing lines in the Drosophila wing: initiation of wing vein development. Curr Opin Genet Dev. 2000 Aug; 10(4):393-8. Bier E. PMID: 10889058.
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    91. sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo. Development. 2000 Aug; 127(16):3631-44. Araujo H, Bier E. PMID: 10903186.
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    92. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development. 2000 May; 127(10):2143-54. Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka KE, Kimelman D, O'Connor MB, Bier E. PMID: 10769238.
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    93. rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development. 1999 Jun; 126(12):2663-76. Guichard A, Biehs B, Sturtevant MA, Wickline L, Chacko J, Howard K, Bier E. PMID: 10331978.
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    94. The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development. 1998 Nov; 125(21):4145-54. Lunde K, Biehs B, Nauber U, Bier E. PMID: 9753669.
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    95. Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development. 1998 Nov; 125(21):4245-57. Biehs B, Sturtevant MA, Bier E. PMID: 9753679.
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    96. Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays. 1998 Mar; 20(3):189-94. Bier E. PMID: 9631645.
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    97. Anti-neural-inhibition: a conserved mechanism for neural induction. Cell. 1997 May 30; 89(5):681-4. Bier E. PMID: 9182755.
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    98. The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development. 1997 Jan; 124(1):21-32. Sturtevant MA, Biehs B, Marin E, Bier E. PMID: 9006064.
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    99. The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. Development. 1996 Dec; 122(12):4033-44. Yu K, Sturtevant MA, Biehs B, François V, Padgett RW, Blackman RK, Bier E. PMID: 9012523.
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    100. The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev. 1996 Nov 15; 10(22):2922-34. Biehs B, François V, Bier E. PMID: 8918893.
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    101. The Drosophila rhomboid protein is concentrated in patches at the apical cell surface. Dev Biol. 1996 Mar 15; 174(2):298-309. Sturtevant MA, Roark M, O'Neill JW, Biehs B, Colley N, Bier E. PMID: 8631502.
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    102. Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression. Development. 1995 Nov; 121(11):3549-60. Emery JF, Bier E. PMID: 8582269.
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    103. Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development. 1995 Mar; 121(3):785-801. Sturtevant MA, Bier E. PMID: 7720583.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    104. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev. 1994 Nov 01; 8(21):2602-16. Francois V, Solloway M, O'Neill JW, Emery J, Bier E. PMID: 7958919.
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    105. Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques. 1994 Nov; 17(5):870, 874-5. O'Neill JW, Bier E. PMID: 7840966.
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    106. Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Development. 1994 Sep; 120(9):2593-600. Sturtevant MA, O'Neill JW, Bier E. PMID: 7956834.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    107. New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracy. Development. 1994 Aug; 120(8):2329-38. Noll R, Sturtevant MA, Gollapudi RR, Bier E. PMID: 7925033.
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    108. Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements. Development. 1994 Jan; 120(1):199-207. Ip YT, Levine M, Bier E. PMID: 8119127.
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    109. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev. 1993 Jun; 7(6):961-73. Sturtevant MA, Roark M, Bier E. PMID: 8504935.
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    110. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev. 1992 Sep; 6(9):1728-39. Ip YT, Park RE, Kosman D, Bier E, Levine M. PMID: 1325394.
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