Ethan Bier

Title(s)Professor, Cell and Developmental Biology
SchoolAcademic Aff
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    Collapse Research 
    Collapse Research Activities and Funding
    Mutagenic chain reaction-facilitated immunotherapy
    NIH/NIAID R01AI131081Sep 9, 2016 - Aug 31, 2021
    Role: Principal Investigator
    The mutagenic chain reaction: a method for autocatalyic gene dissemination
    NIH/NIGMS R01GM117321Apr 1, 2016 - Mar 31, 2020
    Role: Principal Investigator
    Analyzing a novel mechanism of action of bacterial cAMP producing toxins
    NIH/NIAID R01AI110713Feb 1, 2014 - Jan 31, 2019
    Role: Principal Investigator
    The Molecular Genetics of Early Neurogenesis
    NIH/NINDS R56NS029870Aug 1, 2013 - Jul 31, 2014
    Role: Principal Investigator
    Analyzing Anthrox Toxins in Drosophila
    NIH/NIAID R01AI070654Dec 1, 2007 - Nov 30, 2013
    Role: Principal Investigator
    Analyzing Anthrax Toxins in Drosophilia
    NIH/NIAID R56AI070654Jul 1, 2006 - Aug 31, 2014
    Role: Principal Investigator
    Genetic Analysis of Bacterial Toxins in Drosophia
    NIH/NIAID R21AI060976Jun 1, 2004 - May 31, 2007
    Role: Principal Investigator
    Analysis of DPP and Toll Signalling
    NIH/FIC R03TW001329Jul 1, 2000 - Jul 31, 2008
    Role: Principal Investigator
    Analysis of Early Wing Vein Development in Drosophila
    NIH/NIGMS R01GM060585Jan 1, 2000 - Dec 31, 2007
    Role: Principal Investigator
    Molecular Genetics of Early Neurogenesis
    NIH/NINDS R01NS029870May 1, 1992 - Feb 29, 2012
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Grunwald HA, Gantz VM, Poplawski G, Xu XS, Bier E, Cooper KL. Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature. 2019 Jan 23. PMID: 30675057.
      View in: PubMed
    2. Negreiros E, Herszterg S, Kang KH, Câmara A, Dias WB, Carneiro K, Bier E, Todeschini AR, Araujo H. N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs. Development. 2018 Nov 19; 145(22). PMID: 30355725.
      View in: PubMed
    3. Liu JZ, Ali SR, Bier E, Nizet V. Innate Immune Interactions between Bacillus anthracis and Host Neutrophils. Front Cell Infect Microbiol. 2018; 8:2. PMID: 29404280.
      View in: PubMed
    4. Bier E, Harrison MM, O'Connor-Giles KM, Wildonger J. Advances in Engineering the Fly Genome with the CRISPR-Cas System. Genetics. 2018 01; 208(1):1-18. PMID: 29301946.
      View in: PubMed
    5. Xu XS, Gantz VM, Siomava N, Bier E. CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity. Elife. 2017 12 23; 6. PMID: 29274230.
      View in: PubMed
    6. Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017 Sep; 13(9):e1006603. PMID: 28945820.
      View in: PubMed
    7. Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zúñiga EI, Krug RM, Oldstone MB, Bier E. Influenza NS1 directly modulates Hedgehog signaling during infection. PLoS Pathog. 2017 Aug; 13(8):e1006588. PMID: 28837667.
      View in: PubMed
    8. Adelman Z, Akbari O, Bauer J, Bier E, Bloss C, Carter SR, Callender C, Denis AC, Cowhey P, Dass B, Delborne J, Devereaux M, Ellsworth P, Friedman RM, Gantz V, Gibson C, Hay BA, Hoddle M, James AA, James S, Jorgenson L, Kalichman M, Marshall J, McGinnis W, Newman J, Pearson A, Quemada H, Rudenko L, Shelton A, Vinetz JM, Weisman J, Wong B, Wozniak C. Rules of the road for insect gene drive research and testing. Nat Biotechnol. 2017 08 08; 35(8):716-718. PMID: 28787415.
      View in: PubMed
    9. Gantz VM, Bier E. The dawn of active genetics. Bioessays. 2016 Jan; 38(1):50-63. PMID: 26660392.
      View in: PubMed
    10. Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6736-43. PMID: 26598698; PMCID: PMC4679060.
    11. Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J. BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 2015 Aug 28; 349(6251):927-9. PMID: 26229113.
      View in: PubMed
    12. Bier E, De Robertis EM. EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning. Science. 2015 Jun 26; 348(6242):aaa5838. PMID: 26113727.
      View in: PubMed
    13. Gantz VM, Bier E. Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science. 2015 Apr 24; 348(6233):442-4. PMID: 25908821; PMCID: PMC4687737.
    14. Bier E, Nizet V. Hedgehog: linking uracil to innate defense. Cell Host Microbe. 2015 Feb 11; 17(2):146-8. PMID: 25674980.
      View in: PubMed
    15. Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. PMID: 25210771; PMCID: PMC4161316.
    16. Guichard A, Nizet V, Bier E. RAB11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol. 2014 Sep; 12(9):624-34. PMID: 25118884; PMCID: PMC4274738.
    17. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013 Sep 11; 14(3):294-305. PMID: 24034615; PMCID: PMC3786442.
    18. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. PMID: 22958918; PMCID: PMC3687365.
    19. Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 2011 Nov; 7(11):e1002344. PMID: 22072978; PMCID: PMC3207880.
    20. Bier E, Guichard A. Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech. 2012 Jan; 5(1):48-61. PMID: 21979942; PMCID: PMC3255543.
    21. Guichard A, Nizet V, Bier E. New insights into the biological effects of anthrax toxins: linking cellular to organismal responses. Microbes Infect. 2012 Feb; 14(2):97-118. PMID: 21930233; PMCID: PMC3743078.
    22. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 01; 360(1):230-40. PMID: 21920356; PMCID: PMC3661008.
    23. Bier E. Evolution of development: diversified dorsoventral patterning. Curr Biol. 2011 Aug 09; 21(15):R591-4. PMID: 21820625; PMCID: PMC3842600.
    24. Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell. 2011 Jul; 2(7):554-63. PMID: 21822800; PMCID: PMC3702159.
    25. Do LH, Bier E. The Booly aliasing resource: a database of grouped biological identifiers. Bioinformation. 2011 Mar 26; 6(2):83-5. PMID: 21544171; PMCID: PMC3082858.
    26. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010 Oct 14; 467(7317):854-8. PMID: 20944747.
      View in: PubMed
    27. Do LH, Esteves FF, Karten HJ, Bier E. Booly: a new data integration platform. BMC Bioinformatics. 2010 Oct 13; 11:513. PMID: 20942966; PMCID: PMC2970612.
    28. Kang KH, Bier E. dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog. Dev Biol. 2010 Oct 01; 346(1):1-10. PMID: 20599894; PMCID: PMC2937060.
    29. Lee JH, Bodmer R, Bier E, Karin M. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74. PMID: 20606249; PMCID: PMC2919257.
    30. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. PMID: 20203043; PMCID: PMC2866632.
    31. Mizutani CM, Bier E. EvoD/Vo: the origins of BMP signalling in the neuroectoderm. Nat Rev Genet. 2008 Sep; 9(9):663-77. PMID: 18679435; PMCID: PMC2888941.
    32. Bier E. Intriguing extracellular regulation of BMP signaling. Dev Cell. 2008 Aug; 15(2):176-7. PMID: 18694555.
      View in: PubMed
    33. Iyadurai SJ, Robinson JT, Ma L, He Y, Mische S, Li MG, Brown W, Guichard A, Bier E, Hays TS. Dynein and Star interact in EGFR signaling and ligand trafficking. J Cell Sci. 2008 Aug 15; 121(Pt 16):2643-51. PMID: 18653542; PMCID: PMC2633900.
    34. Reiter LT, Do LH, Fischer MS, Hong NA, Bier E. Accentuate the negative: proteome comparisons using the negative proteome database. Fly (Austin). 2007 May-Jun; 1(3):164-71. PMID: 18820470.
      View in: PubMed
    35. Mizutani CM, Meyer N, Roelink H, Bier E. Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm. PLoS Biol. 2006 Oct; 4(10):e313. PMID: 16968133; PMCID: PMC1563485.
    36. Bier E. Antioxidants put Parkinson flies back in the PINK. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13269-70. PMID: 16938856; PMCID: PMC1569152.
    37. Reiter LT, Seagroves TN, Bowers M, Bier E. Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet. 2006 Sep 15; 15(18):2825-35. PMID: 16905559; PMCID: PMC3742451.
    38. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9. PMID: 16455799.
      View in: PubMed
    39. Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug; 233(4):1315-31. PMID: 15965977.
      View in: PubMed
    40. Mizutani CM, Nie Q, Wan FY, Zhang YT, Vilmos P, Sousa-Neves R, Bier E, Marsh JL, Lander AD. Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell. 2005 Jun; 8(6):915-24. PMID: 15935780; PMCID: PMC1829168.
    41. Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet. 2005 Jan; 6(1):9-23. PMID: 15630418.
      View in: PubMed
    42. Bier E, Bodmer R. Drosophila, an emerging model for cardiac disease. Gene. 2004 Nov 10; 342(1):1-11. PMID: 15527959.
      View in: PubMed
    43. Kosman D, Mizutani CM, Lemons D, Cox WG, McGinnis W, Bier E. Multiplex detection of RNA expression in Drosophila embryos. Science. 2004 Aug 06; 305(5685):846. PMID: 15297669.
      View in: PubMed
    44. Cook O, Biehs B, Bier E. brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Development. 2004 May; 131(9):2113-24. PMID: 15073155.
      View in: PubMed
    45. Yu K, Kang KH, Heine P, Pyati U, Srinivasan S, Biehs B, Kimelman D, Bier E. Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein. Genetics. 2004 Mar; 166(3):1323-36. PMID: 15082551; PMCID: PMC1470778.
    46. Araujo H, Negreiros E, Bier E. Integrins modulate Sog activity in the Drosophila wing. Development. 2003 Aug; 130(16):3851-64. PMID: 12835400.
      View in: PubMed
    47. Hériché JK, Ang D, Bier E, O'Farrell PH. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003 Jun 04; 4:9. PMID: 12787468; PMCID: PMC161817.
    48. Lunde K, Trimble JL, Guichard A, Guss KA, Nauber U, Bier E. Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development. 2003 Jan; 130(2):235-48. PMID: 12466192.
      View in: PubMed
    49. Reiter LT, Bier E. Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert Opin Ther Targets. 2002 Jun; 6(3):387-99. PMID: 12223075.
      View in: PubMed
    50. Guichard A, Srinivasan S, Zimm G, Bier E. A screen for dominant mutations applied to components in the Drosophila EGF-R pathway. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3752-7. PMID: 11904431; PMCID: PMC122596.
    51. Srinivasan S, Rashka KE, Bier E. Creation of a Sog morphogen gradient in the Drosophila embryo. Dev Cell. 2002 Jan; 2(1):91-101. PMID: 11782317.
      View in: PubMed
    52. Chien S, Reiter LT, Bier E, Gribskov M. Homophila: human disease gene cognates in Drosophila. Nucleic Acids Res. 2002 Jan 01; 30(1):149-51. PMID: 11752278; PMCID: PMC99119.