Ethan Bier

Title(s)Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Mutagenic chain reaction-facilitated immunotherapy
    NIH R01AI131081Sep 9, 2016 - Aug 31, 2021
    Role: Principal Investigator
    The mutagenic chain reaction: a method for autocatalyic gene dissemination
    NIH R01GM117321Apr 1, 2016 - Mar 31, 2025
    Role: Principal Investigator
    Analyzing a novel mechanism of action of bacterial cAMP producing toxins
    NIH R01AI110713Feb 1, 2014 - Jan 31, 2020
    Role: Principal Investigator
    The Molecular Genetics of Early Neurogenesis
    NIH R56NS029870Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Analyzing Anthrox Toxins in Drosophila
    NIH R01AI070654Dec 1, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Analyzing Anthrax Toxins in Drosophilia
    NIH R56AI070654Jul 1, 2006 - Aug 31, 2015
    Role: Principal Investigator
    Genetic Analysis of Bacterial Toxins in Drosophia
    NIH R21AI060976Jun 1, 2004 - May 31, 2007
    Role: Principal Investigator
    Analysis of DPP and Toll Signalling
    NIH R03TW001329Jul 1, 2000 - Jul 31, 2008
    Role: Principal Investigator
    Analysis of Early Wing Vein Development in Drosophila
    NIH R01GM060585Jan 1, 2000 - Dec 31, 2007
    Role: Principal Investigator
    Molecular Genetics of Early Neurogenesis
    NIH R01NS029870May 1, 1992 - Feb 29, 2012
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: tgCRISPRi: efficient gene knock-down using truncated gRNAs and catalytically active Cas9. Nat Commun. 2024 Apr 12; 15(1):3183. Auradkar A, Guichard A, Kaduwal S, Sneider M, Bier E. PMID: 38609401; PMCID: PMC11015020.
      View in: PubMed   Mentions:
    2. Developmental progression of DNA double-strand break repair deciphered by a single-allele resolution mutation classifier. Nat Commun. 2024 Mar 23; 15(1):2629. Li Z, You L, Hermann A, Bier E. PMID: 38521791; PMCID: PMC10960810.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    3. tgCRISPRi: efficient gene knock-down using truncated gRNAs and catalytically active Cas9. Nat Commun. 2023 09 11; 14(1):5587. Auradkar A, Guichard A, Kaduwal S, Sneider M, Bier E. PMID: 37696787; PMCID: PMC10495392.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Cell Rep. 2023 08 29; 42(8):112842. Guichard A, Lu S, Kanca O, Bressan D, Huang Y, Ma M, Sanz Juste S, Andrews JC, Jay KL, Sneider M, Schwartz R, Huang MC, Bei D, Pan H, Ma L, Lin WW, Auradkar A, Bhagwat P, Park S, Wan KH, Ohsako T, Takano-Shimizu T, Celniker SE, Wangler MF, Yamamoto S, Bellen HJ, Bier E. PMID: 37480566; PMCID: PMC10962759.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Genetic conversion of a split-drive into a full-drive element. Nat Commun. 2023 01 12; 14(1):191. Terradas G, Bennett JB, Li Z, Marshall JM, Bier E. PMID: 36635291; PMCID: PMC9837192.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells. Sci Adv. 2022 07; 8(26):eabo0721. Roy S, Juste SS, Sneider M, Auradkar A, Klanseck C, Li Z, Julio AHF, Lopez del Amo V, Bier E, Guichard A. PMID: 35776792; PMCID: PMC10883370.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoes. G3 (Bethesda). 2022 01 04; 12(1). Terradas G, Hermann A, James AA, McGinnis W, Bier E. PMID: 34791161; PMCID: PMC8728002.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    8. Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline. PLoS Biol. 2021 Dec; 19(12):e3001478. Weitzel AJ, Grunwald HA, Weber C, Levina R, Gantz VM, Hedrick SM, Bier E, Cooper KL. PMID: 34941868; PMCID: PMC8699911.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Dissecting the evolutionary role of the Hox gene proboscipedia in Drosophila mouthpart diversification by full locus replacement. Sci Adv. 2021 Nov 12; 7(46):eabk1003. Auradkar A, Bulger EA, Devkota S, McGinnis W, Bier E. PMID: 34757777; PMCID: PMC8580299.
      View in: PubMed   Mentions: 1     Fields:    
    10. Gene drives gaining speed. Nat Rev Genet. 2022 Jan; 23(1):5-22. Bier E. PMID: 34363067; PMCID: PMC8344398.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    11. CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion. Nat Commun. 2021 05 11; 12(1):2625. Li Z, Marcel N, Devkota S, Auradkar A, Hedrick SM, Gantz VM, Bier E. PMID: 33976171; PMCID: PMC8113449.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Driving to Safety: CRISPR-Based Genetic Approaches to Reducing Antibiotic Resistance. Trends Genet. 2021 08; 37(8):745-757. Bier E, Nizet V. PMID: 33745750.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Inherently confinable split-drive systems in Drosophila. Nat Commun. 2021 03 05; 12(1):1480. Terradas G, Buchman AB, Bennett JB, Shriner I, Marshall JM, Akbari OS, Bier E. PMID: 33674604; PMCID: PMC7935863.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives. Mol Cell. 2020 Oct 15; 80(2):246-262.e4. Xu XS, Bulger EA, Gantz VM, Klanseck C, Heimler SR, Auradkar A, Bennett JB, Miller LA, Leahy S, Juste SS, Buchman A, Akbari OS, Marshall JM, Bier E. PMID: 32949493; PMCID: PMC10962758.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    15. A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. iScience. 2020 Feb 21; 23(2):100865. Schwartz R, Guichard A, Franc NC, Roy S, Bier E. PMID: 32058973; PMCID: PMC7011083.
      View in: PubMed   Mentions: 3  
    16. A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment. Nat Commun. 2020 Jan 17; 11(1):352. López Del Amo V, Bishop AL, Sánchez C HM, Bennett JB, Feng X, Marshall JM, Bier E, Gantz VM. PMID: 31953404; PMCID: PMC6969112.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    17. Author Correction: Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature. 2020 01; 577(7792):E8. Grunwald HA, Gantz VM, Poplawski G, Xu XS, Bier E, Cooper KL. PMID: 31911657.
      View in: PubMed   Mentions: 1     Fields:    
    18. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Commun. 2019 Dec 16; 10(1):5726. Valderrama JA, Kulkarni SS, Nizet V, Bier E. PMID: 31844051; PMCID: PMC6915771.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    19. Efficient allelic-drive in Drosophila. Nat Commun. 2019 04 09; 10(1):1640. Guichard A, Haque T, Bobik M, Xu XS, Klanseck C, Kushwah RBS, Berni M, Kaduskar B, Gantz VM, Bier E. PMID: 30967548; PMCID: PMC6456580.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    20. Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline. Nature. 2019 Feb; 566(7742):105-109. Grunwald HA, Gantz VM, Poplawski G, Xu XS, Bier E, Cooper KL. PMID: 30675057; PMCID: PMC6367021.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    21. Innate Immune Interactions between Bacillus anthracis and Host Neutrophils. Front Cell Infect Microbiol. 2018; 8:2. Liu JZ, Ali SR, Bier E, Nizet V. PMID: 29404280; PMCID: PMC5786542.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Advances in Engineering the Fly Genome with the CRISPR-Cas System. Genetics. 2018 Jan; 208(1):1-18. Bier E, Harrison MM, O'Connor-Giles KM, Wildonger J. PMID: 29301946; PMCID: PMC5753851.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    23. CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity. Elife. 2017 12 23; 6. Xu XS, Gantz VM, Siomava N, Bier E. PMID: 29274230; PMCID: PMC5800851.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    24. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017 Sep; 13(9):e1006603. Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E. PMID: 28945820; PMCID: PMC5612732.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Influenza NS1 directly modulates Hedgehog signaling during infection. PLoS Pathog. 2017 Aug; 13(8):e1006588. Smelkinson MG, Guichard A, Teijaro JR, Malur M, Loureiro ME, Jain P, Ganesan S, Zúñiga EI, Krug RM, Oldstone MB, Bier E. PMID: 28837667; PMCID: PMC5587344.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. The dawn of active genetics. Bioessays. 2016 Jan; 38(1):50-63. Gantz VM, Bier E. PMID: 26660392; PMCID: PMC5819344.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    27. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6736-43. Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA. PMID: 26598698; PMCID: PMC4679060.
      View in: PubMed   Mentions: 394     Fields:    Translation:AnimalsCellsPHPublic Health
    28. EMBRYO DEVELOPMENT. BMP gradients: A paradigm for morphogen-mediated developmental patterning. Science. 2015 Jun 26; 348(6242):aaa5838. Bier E, De Robertis EM. PMID: 26113727.
      View in: PubMed   Mentions: 114     Fields:    Translation:Animals
    29. Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science. 2015 Apr 24; 348(6233):442-4. Gantz VM, Bier E. PMID: 25908821; PMCID: PMC4687737.
      View in: PubMed   Mentions: 223     Fields:    Translation:AnimalsCells
    30. Hedgehog: linking uracil to innate defense. Cell Host Microbe. 2015 Feb 11; 17(2):146-8. Bier E, Nizet V. PMID: 25674980.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    31. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. PMID: 25210771; PMCID: PMC4161316.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. RAB11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol. 2014 Sep; 12(9):624-34. Guichard A, Nizet V, Bier E. PMID: 25118884; PMCID: PMC4274738.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    33. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013 Sep 11; 14(3):294-305. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. PMID: 24034615; PMCID: PMC3786442.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    34. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. PMID: 22958918; PMCID: PMC3687365.
      View in: PubMed   Mentions: 141     Fields:    Translation:Animals
    35. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 2011 Nov; 7(11):e1002344. Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. PMID: 22072978; PMCID: PMC3207880.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    36. Deconstructing host-pathogen interactions in Drosophila. Dis Model Mech. 2012 Jan; 5(1):48-61. Bier E, Guichard A. PMID: 21979942; PMCID: PMC3255543.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    37. New insights into the biological effects of anthrax toxins: linking cellular to organismal responses. Microbes Infect. 2012 Feb; 14(2):97-118. Guichard A, Nizet V, Bier E. PMID: 21930233; PMCID: PMC3743078.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    38. Gene length may contribute to graded transcriptional responses in the Drosophila embryo. Dev Biol. 2011 Dec 01; 360(1):230-40. McHale P, Mizutani CM, Kosman D, MacKay DL, Belu M, Hermann A, McGinnis W, Bier E, Hwa T. PMID: 21920356; PMCID: PMC3661008.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. Evolution of development: diversified dorsoventral patterning. Curr Biol. 2011 Aug 09; 21(15):R591-4. Bier E. PMID: 21820625; PMCID: PMC3842600.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    40. Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell. 2011 Jul; 2(7):554-63. Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. PMID: 21822800; PMCID: PMC3702159.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    41. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010 Oct 14; 467(7317):854-8. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. PMID: 20944747; PMCID: PMC5831355.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    42. Booly: a new data integration platform. BMC Bioinformatics. 2010 Oct 13; 11:513. Do LH, Esteves FF, Karten HJ, Bier E. PMID: 20942966; PMCID: PMC2970612.
      View in: PubMed   Mentions: 2     Fields:    
    43. dHIP14-dependent palmitoylation promotes secretion of the BMP antagonist Sog. Dev Biol. 2010 Oct 01; 346(1):1-10. Kang KH, Bier E. PMID: 20599894; PMCID: PMC2937060.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    44. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74. Lee JH, Bodmer R, Bier E, Karin M. PMID: 20606249; PMCID: PMC2919257.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    45. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. PMID: 20203043; PMCID: PMC2866632.
      View in: PubMed   Mentions: 289     Fields:    Translation:AnimalsCells
    46. EvoD/Vo: the origins of BMP signalling in the neuroectoderm. Nat Rev Genet. 2008 Sep; 9(9):663-77. Mizutani CM, Bier E. PMID: 18679435; PMCID: PMC2888941.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    47. Intriguing extracellular regulation of BMP signaling. Dev Cell. 2008 Aug; 15(2):176-7. Bier E. PMID: 18694555.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    48. Accentuate the negative: proteome comparisons using the negative proteome database. Fly (Austin). 2007 May-Jun; 1(3):164-71. Reiter LT, Do LH, Fischer MS, Hong NA, Bier E. PMID: 18820470.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    49. Threshold-dependent BMP-mediated repression: a model for a conserved mechanism that patterns the neuroectoderm. PLoS Biol. 2006 Oct; 4(10):e313. Mizutani CM, Meyer N, Roelink H, Bier E. PMID: 16968133; PMCID: PMC1563485.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    50. Antioxidants put Parkinson flies back in the PINK. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13269-70. Bier E. PMID: 16938856; PMCID: PMC1569152.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    51. Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. Hum Mol Genet. 2006 Sep 15; 15(18):2825-35. Reiter LT, Seagroves TN, Bowers M, Bier E. PMID: 16905559; PMCID: PMC3742451.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    52. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. PMID: 16455799; PMCID: PMC1413899.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    53. Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell. 2005 Jun; 8(6):915-24. Mizutani CM, Nie Q, Wan FY, Zhang YT, Vilmos P, Sousa-Neves R, Bier E, Marsh JL, Lander AD. PMID: 15935780; PMCID: PMC1829168.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    54. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet. 2005 Jan; 6(1):9-23. Bier E. PMID: 15630418.
      View in: PubMed   Mentions: 261     Fields:    Translation:HumansAnimalsCells
    55. Drosophila, an emerging model for cardiac disease. Gene. 2004 Nov 10; 342(1):1-11. Bier E, Bodmer R. PMID: 15527959.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimals
    56. Multiplex detection of RNA expression in Drosophila embryos. Science. 2004 Aug 06; 305(5685):846. Kosman D, Mizutani CM, Lemons D, Cox WG, McGinnis W, Bier E. PMID: 15297669.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    57. brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila. Development. 2004 May; 131(9):2113-24. Cook O, Biehs B, Bier E. PMID: 15073155.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    58. Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein. Genetics. 2004 Mar; 166(3):1323-36. Yu K, Kang KH, Heine P, Pyati U, Srinivasan S, Biehs B, Kimelman D, Bier E. PMID: 15082551; PMCID: PMC1470778.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    59. Activation of the knirps locus links patterning to morphogenesis of the second wing vein in Drosophila. Development. 2003 Jan; 130(2):235-48. Lunde K, Trimble JL, Guichard A, Guss KA, Nauber U, Bier E. PMID: 12466192.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    60. Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert Opin Ther Targets. 2002 Jun; 6(3):387-99. Reiter LT, Bier E. PMID: 12223075.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    61. A screen for dominant mutations applied to components in the Drosophila EGF-R pathway. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3752-7. Guichard A, Srinivasan S, Zimm G, Bier E. PMID: 11904431; PMCID: PMC122596.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    62. Homophila: human disease gene cognates in Drosophila. Nucleic Acids Res. 2002 Jan 01; 30(1):149-51. Chien S, Reiter LT, Bier E, Gribskov M. PMID: 11752278; PMCID: PMC99119.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    63. Creation of a Sog morphogen gradient in the Drosophila embryo. Dev Cell. 2002 Jan; 2(1):91-101. Srinivasan S, Rashka KE, Bier E. PMID: 11782317.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    64. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 2001 Jun; 11(6):1114-25. Reiter LT, Potocki L, Chien S, Gribskov M, Bier E. PMID: 11381037; PMCID: PMC311089.
      View in: PubMed   Mentions: 350     Fields:    Translation:HumansAnimalsCells
    65. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev Biol. 2000 Oct 15; 226(2):255-66. Guichard A, Roark M, Ronshaugen M, Bier E. PMID: 11023685.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    66. Drawing lines in the Drosophila wing: initiation of wing vein development. Curr Opin Genet Dev. 2000 Aug; 10(4):393-8. Bier E. PMID: 10889058.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    67. sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo. Development. 2000 Aug; 127(16):3631-44. Araujo H, Bier E. PMID: 10903186.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    68. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development. 2000 May; 127(10):2143-54. Yu K, Srinivasan S, Shimmi O, Biehs B, Rashka KE, Kimelman D, O'Connor MB, Bier E. PMID: 10769238.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    69. rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development. 1999 Jun; 126(12):2663-76. Guichard A, Biehs B, Sturtevant MA, Wickline L, Chacko J, Howard K, Bier E. PMID: 10331978.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    70. The knirps and knirps-related genes organize development of the second wing vein in Drosophila. Development. 1998 Nov; 125(21):4145-54. Lunde K, Biehs B, Nauber U, Bier E. PMID: 9753669.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    71. Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development. 1998 Nov; 125(21):4245-57. Biehs B, Sturtevant MA, Bier E. PMID: 9753679.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    72. Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays. 1998 Mar; 20(3):189-94. Bier E. PMID: 9631645.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    73. Anti-neural-inhibition: a conserved mechanism for neural induction. Cell. 1997 May 30; 89(5):681-4. Bier E. PMID: 9182755.
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    74. The spalt gene links the A/P compartment boundary to a linear adult structure in the Drosophila wing. Development. 1997 Jan; 124(1):21-32. Sturtevant MA, Biehs B, Marin E, Bier E. PMID: 9006064.
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    75. The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development. Development. 1996 Dec; 122(12):4033-44. Yu K, Sturtevant MA, Biehs B, François V, Padgett RW, Blackman RK, Bier E. PMID: 9012523.
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    76. The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev. 1996 Nov 15; 10(22):2922-34. Biehs B, François V, Bier E. PMID: 8918893.
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    77. The Drosophila rhomboid protein is concentrated in patches at the apical cell surface. Dev Biol. 1996 Mar 15; 174(2):298-309. Sturtevant MA, Roark M, O'Neill JW, Biehs B, Colley N, Bier E. PMID: 8631502.
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    78. Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression. Development. 1995 Nov; 121(11):3549-60. Emery JF, Bier E. PMID: 8582269.
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    79. Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development. 1995 Mar; 121(3):785-801. Sturtevant MA, Bier E. PMID: 7720583.
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    80. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes Dev. 1994 Nov 01; 8(21):2602-16. Francois V, Solloway M, O'Neill JW, Emery J, Bier E. PMID: 7958919.
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    81. Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques. 1994 Nov; 17(5):870, 874-5. O'Neill JW, Bier E. PMID: 7840966.
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    82. Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Development. 1994 Sep; 120(9):2593-600. Sturtevant MA, O'Neill JW, Bier E. PMID: 7956834.
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    83. New functions of the Drosophila rhomboid gene during embryonic and adult development are revealed by a novel genetic method, enhancer piracy. Development. 1994 Aug; 120(8):2329-38. Noll R, Sturtevant MA, Gollapudi RR, Bier E. PMID: 7925033.
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    84. Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements. Development. 1994 Jan; 120(1):199-207. Ip YT, Levine M, Bier E. PMID: 8119127.
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    85. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev. 1993 Jun; 7(6):961-73. Sturtevant MA, Roark M, Bier E. PMID: 8504935.
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    86. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev. 1992 Sep; 6(9):1728-39. Ip YT, Park RE, Kosman D, Bier E, Levine M. PMID: 1325394.
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