Frank Powell

Title(s)Recall Hcomp, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-5166-4347 Additional info
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    Title(s)Chief, Division of Physiology

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    The primary objective or our laboratory in the Division of Physiology is to determine the mechanisms of neural plasticity with hypoxia, which occurs with lung disease and sleep disordered breathing.

    In collaboration with investigators from the Division of Pulmonary and Critical Care Medicine, we focus on the physiological mechanisms of acclimatization to chronic sustained and intermittent hypoxia in the reflexes that control breathing and the cardiovascular system. We study both the genetic determinants of this physiology in healthy humans from sea level and high altitude populations in the Andes and Tibet, and in patients with chronic lung disease. We are especially interested in mechanisms of plasticity in chemoreceptors and respiratory microcircuits in the brain.

    Experimental models in our laboratory include: (1) healthy humans acclimatizing to high altitude and human patients with chronic lung disease and obstructive sleep apnea; (2) conscious, freely moving and behaving rats and transgenic mice using telemetry and chronic physiological instrumentation; (3) neurophysiological preparations and in vivo imaging of cellular and molecular signals for neural plasticity in anesthetized laboratory rodents; (4) computer models of respiratory function.

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    Collapse Research Activities and Funding
    Training in the Next Generation in Respiratory Science
    NIH T32HL134632Feb 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Training in Respiratory Biology: Innovate, Integrate, and Translate
    NIH T32HL098062Sep 20, 2010 - Aug 31, 2017
    Role: Principal Investigator
    Molecular mechanisms of hypoxia tolerance and susceptibility
    NIH P01HL098053Jul 1, 2010 - Jun 30, 2015
    Role: Co-Investigator
    Neural Plasticity During Acclimatization to Hypoxia
    NIH R01HL081823Aug 15, 2005 - Feb 28, 2021
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator
    NIH P01HL017731Apr 30, 2006
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Time Domains of Hypoxia Responses and -Omics Insights. Front Physiol. 2022; 13:885295. Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O'Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, Vázquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL, Simonson TS. PMID: 36035495; PMCID: PMC9400701.
      View in: PubMed   Mentions: 6  
    2. Impacts of Changes in Atmospheric O2 on Human Physiology. Is There a Basis for Concern? Front Physiol. 2021; 12:571137. Keeling RF, Powell FL, Shaffer G, Robbins PA, Simonson TS. PMID: 33737880; PMCID: PMC7960674.
      View in: PubMed   Mentions: 2  
    3. Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women. Front Physiol. 2020; 11:437. Heinrich EC, Orr JE, Gilbertson D, Anza-Ramirez C, DeYoung PN, Djokic MA, Corante N, Vizcardo-Galindo G, Macarlupu JL, Gaio E, Powell FL, Malhotra A, Villafuerte FC, Simonson TS. PMID: 32435207; PMCID: PMC7219107.
      View in: PubMed   Mentions: 9  
    4. Neuronal HIF-1α in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia. J Physiol. 2020 05; 598(10):2021-2034. Moya EA, Go A, Kim CB, Fu Z, Simonson TS, Powell FL. PMID: 32026480; PMCID: PMC7230006.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    5. Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. PLoS One. 2019; 14(6):e0217089. Heinrich EC, Djokic MA, Gilbertson D, DeYoung PN, Bosompra NO, Wu L, Anza-Ramirez C, Orr JE, Powell FL, Malhotra A, Simonson TS. PMID: 31188839; PMCID: PMC6561544.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    6. Serotonin and Adenosine G-protein Coupled Receptor Signaling for Ventilatory Acclimatization to Sustained Hypoxia. Front Physiol. 2018; 9:860. Moya EA, Powell FL. PMID: 30072908; PMCID: PMC6059110.
      View in: PubMed   Mentions:
    7. Computational model of brain-stem circuit for state-dependent control of hypoglossal motoneurons. J Neurophysiol. 2018 07 01; 120(1):296-305. Naji M, Komarov M, Krishnan GP, Malhotra A, Powell FL, Rukhadze I, Fenik VB, Bazhenov M. PMID: 29617218; PMCID: PMC6093961.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals. High Alt Med Biol. 2018 06; 19(2):178-184. Orr JE, Heinrich EC, Djokic M, Gilbertson D, Deyoung PN, Anza-Ramirez C, Villafuerte FC, Powell FL, Malhotra A, Simonson T. PMID: 29641294; PMCID: PMC6014053.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    9. Evidence from high-altitude acclimatization for an integrated cerebrovascular and ventilatory hypercapnic response but different responses to hypoxia. J Appl Physiol (1985). 2017 12 01; 123(6):1477-1486. Smith ZM, Krizay E, Sá RC, Li ET, Scadeng M, Powell FL, Dubowitz DJ. PMID: 28705997; PMCID: PMC6734088.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Giants in Chest Medicine: John B. West, MD, PhD, DSc. Chest. 2017 07; 152(1):10-12. Powell FL. PMID: 28693761.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Minocycline blocks glial cell activation and ventilatory acclimatization to hypoxia. J Neurophysiol. 2017 04 01; 117(4):1625-1635. Stokes JA, Arbogast TE, Moya EA, Fu Z, Powell FL. PMID: 28100653; PMCID: PMC5380779.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    12. Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans. PLoS One. 2016; 11(1):e0146087. Basaran KE, Villongco M, Ho B, Ellis E, Zarndt R, Antonova J, Hopkins SR, Powell FL. PMID: 26726885; PMCID: PMC4699648.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsCTClinical Trials
    13. A Protocol to Collect Specific Mouse Skeletal Muscles for Metabolomics Studies. Methods Mol Biol. 2016; 1375:169-79. Gan Z, Fu Z, Stowe JC, Powell FL, McCulloch AD. PMID: 26003134.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    14. Cardiac responses to hypoxia and reoxygenation in Drosophila. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 01; 309(11):R1347-57. Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K. PMID: 26377557; PMCID: PMC4698404.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    15. No evidence of a role for neuronal nitric oxide synthase in the nucleus tractus solitarius in ventilatory responses to acute or chronic hypoxia in awake rats. J Appl Physiol (1985). 2015 Mar 15; 118(6):750-9. Pamenter ME, Go A, Fu Z, Powell FL. PMID: 25571988; PMCID: PMC4360023.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. The effect of combined glutamate receptor blockade in the NTS on the hypoxic ventilatory response in awake rats differs from the effect of individual glutamate receptor blockade. Physiol Rep. 2014 Aug 01; 2(8). Pamenter ME, Nguyen J, Carr JA, Powell FL. PMID: 25107985; PMCID: PMC4246593.
      View in: PubMed   Mentions: 13     Fields:    
    17. Adaptive responses using obstructive sleep apnea as the paradigm. Physiology (Bethesda). 2014 May; 29(3):153-5. Malhotra A, Deacon N, Powell F, Katz ES. PMID: 24789977; PMCID: PMC4888960.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    18. Glutamate receptors in the nucleus tractus solitarius contribute to ventilatory acclimatization to hypoxia in rat. J Physiol. 2014 Apr 15; 592(8):1839-56. Pamenter ME, Carr JA, Go A, Fu Z, Reid SG, Powell FL. PMID: 24492841; PMCID: PMC4001756.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    19. Less is more: blunted responses to hypoxia revealed in sea-level Tibetans. J Appl Physiol (1985). 2014 Apr 01; 116(7):711-2. Simonson TS, Powell FL. PMID: 24114703.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Signalling mechanisms of long term facilitation of breathing with intermittent hypoxia. F1000Prime Rep. 2013; 5:23. Pamenter ME, Powell FL. PMID: 23864930; PMCID: PMC3702218.
      View in: PubMed   Mentions: 5  
    21. Chemokine receptor-like 2 is involved in ischemic brain injury. J Exp Stroke Transl Med. 2013 Feb 17; 6:1-6. Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell FL, Haddad GG, Yao H. PMID: 23847708; PMCID: PMC3705577.
      View in: PubMed   Mentions: 4  
    22. Transposon tagging in diploid strawberry. Plant Biotechnol J. 2012 Oct; 10(8):985-94. Veilleux RE, Mills KP, Baxter AJ, Upham KT, Ferguson TJ, Holt SH, Lu N, Ruiz-Rojas JJ, Pantazis CJ, Davis CM, Lindsay RC, Powell FL, Dan Y, Dickerman AW, Oosumi T, Shulaev V. PMID: 22845757.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Measuring the respiratory chemoreflexes in humans by J. Duffin. Respir Physiol Neurobiol. 2012 Apr 15; 181(1):44-5. Powell FL. PMID: 22306918.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. Inflammation and cardio-respiratory control. Foreword. Respir Physiol Neurobiol. 2011 Sep 30; 178(3):359-61. Powell FL, Kou YR. PMID: 21712104.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    25. Ventilatory effects of substance P-saporin lesions in the nucleus tractus solitarii of chronically hypoxic rats. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R343-50. Wilkinson KA, Fu Z, Powell FL. PMID: 21593425; PMCID: PMC3154706.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats. Respir Physiol Neurobiol. 2011 Sep 30; 178(3):381-6. Popa D, Fu Z, Go A, Powell FL. PMID: 21457799; PMCID: PMC3158279.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    27. Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters. Circ Heart Fail. 2011 Jan; 4(1):89-97. Hoshijima M, Hayashi T, Jeon YE, Fu Z, Gu Y, Dalton ND, Ellisman MH, Xiao X, Powell FL, Ross J. PMID: 21036890; PMCID: PMC3742303.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    28. Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system. J Appl Physiol (1985). 2010 Aug; 109(2):424-30. Wilkinson KA, Huey K, Dinger B, He L, Fidone S, Powell FL. PMID: 20489036; PMCID: PMC2928595.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 05; 11(5):364-78. Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS. PMID: 20399150; PMCID: PMC2893150.
      View in: PubMed   Mentions: 122     Fields:    Translation:Animals
    30. Studying biological responses to global change in atmospheric oxygen. Respir Physiol Neurobiol. 2010 Aug 31; 173 Suppl:S6-12. Powell FL. PMID: 20385257; PMCID: PMC2923684.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    31. Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Ann N Y Acad Sci. 2009 Oct; 1177:101-11. Firth AL, Platoshyn O, Brevnova EE, Burg ED, Powell F, Haddad GH, Yuan JX. PMID: 19845612.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. Oxygen sensing in the brain--invited article. Adv Exp Med Biol. 2009; 648:369-76. Powell FL, Kim BC, Johnson SR, Fu Z. PMID: 19536501.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. HIF-1 and ventilatory acclimatization to chronic hypoxia. Respir Physiol Neurobiol. 2008 Dec 10; 164(1-2):282-7. Powell FL, Fu Z. PMID: 18708172; PMCID: PMC2700119.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    34. Respiratory plasticity in response to changes in oxygen supply and demand. Integr Comp Biol. 2007 Oct; 47(4):532-51. Bavis RW, Powell FL, Bradford A, Hsia CC, Peltonen JE, Soliz J, Zeis B, Fergusson EK, Fu Z, Gassmann M, Kim CB, Maurer J, McGuire M, Miller BM, O'Halloran KD, Paul RJ, Reid SG, Rusko HK, Tikkanen HO, Wilkinson KA. PMID: 21672862.
      View in: PubMed   Mentions: 5     Fields:    
    35. Commentary on: "Major differences in the pulmonary circulation of birds and mammals" by John B. West, Rebecca R. Watson and Zhenxing Fu. Respir Physiol Neurobiol. 2007 Aug 01; 157(2-3):391-2. Powell FL. PMID: 17412654.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    36. The influence of chronic hypoxia upon chemoreception. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):154-61. Powell FL. PMID: 17291837; PMCID: PMC1964780.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    37. A strategy for determining arterial blood gases on the summit of Mt. Everest. BMC Physiol. 2006 Mar 08; 6:3. Catron TF, Powell FL, West JB. PMID: 16524477; PMCID: PMC1421431.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    38. Lake Louise consensus methods for measuring the hypoxic ventilatory response. Adv Exp Med Biol. 2006; 588:271-6. Powell FL. PMID: 17089895.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Breathing in thin air: acclimatization to altitude in ducks. Respir Physiol Neurobiol. 2004 Dec 15; 144(2-3):225-35. Powell FL, Shams H, Hempleman SC, Mitchell GS. PMID: 15556105.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    40. Increased hypoxic ventilatory response during 8 weeks at 3800 m altitude. Respir Physiol Neurobiol. 2004 Sep 15; 142(2-3):145-52. Hupperets MD, Hopkins SR, Pronk MG, Tiemessen IJ, Garcia N, Wagner PD, Powell FL. PMID: 15450476.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    41. Comparative physiology of lung complexity: implications for gas exchange. News Physiol Sci. 2004 Apr; 19:55-60. Powell FL, Hopkins SR. PMID: 15016903.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    42. Persistence of the lactate paradox over 8 weeks at 3,800 m. High Alt Med Biol. 2003; 4(4):431-43. Pronk M, Tiemessen I, Hupperets MD, Kennedy BP, Powell FL, Hopkins SR, Wagner PD. PMID: 14672546.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Functional genomics and the comparative physiology of hypoxia. Annu Rev Physiol. 2003; 65:203-30. Powell FL. PMID: 12471168.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    44. Measuring ventilatory acclimatization to hypoxia: comparative aspects. Respir Physiol. 2000 Sep; 122(2-3):271-84. Powell FL, Dwinell MR, Aaron EA. PMID: 10967350.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    45. Central nervous system mechanisms of ventilatory acclimatization to hypoxia. Respir Physiol. 2000 Jul; 121(2-3):223-36. Powell FL, Huey KA, Dwinell MR. PMID: 10963777.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    46. Physiological effects of intermittent hypoxia. High Alt Med Biol. 2000; 1(2):125-36. Powell FL, Garcia N. PMID: 11256564.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    47. Time domains of the hypoxic ventilatory response. Respir Physiol. 1998 May; 112(2):123-34. Powell FL, Milsom WK, Mitchell GS. PMID: 9716296.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimals
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