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    Frank Powell

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0623-A
    CA La Jolla 92093
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      TitleChief, Division of Physiology

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      Collapse Overview
      The primary objective or our laboratory in the Division of Physiology is to determine the mechanisms of neural plasticity with hypoxia, which occurs with lung disease and sleep disordered breathing.

      In collaboration with investigators from the Division of Pulmonary and Critical Care Medicine, we focus on the physiological mechanisms of acclimatization to chronic sustained and intermittent hypoxia in the reflexes that control breathing and the cardiovascular system. We study both the genetic determinants of this physiology in healthy humans from sea level and high altitude populations in the Andes and Tibet, and in patients with chronic lung disease. We are especially interested in mechanisms of plasticity in chemoreceptors and respiratory microcircuits in the brain.

      Experimental models in our laboratory include: (1) healthy humans acclimatizing to high altitude and human patients with chronic lung disease and obstructive sleep apnea; (2) conscious, freely moving and behaving rats and transgenic mice using telemetry and chronic physiological instrumentation; (3) neurophysiological preparations and in vivo imaging of cellular and molecular signals for neural plasticity in anesthetized laboratory rodents; (4) computer models of respiratory function.

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      Training in the Next Generation in Respiratory Science
      NIH/NHLBI T32HL134632Feb 1, 2017 - Jan 31, 2022
      Role: Principal Investigator
      Training in Respiratory Biology: Innovate, Integrate, and Translate
      NIH/NHLBI T32HL098062Sep 20, 2010 - Aug 31, 2015
      Role: Principal Investigator
      Molecular mechanisms of hypoxia tolerance and susceptibility
      NIH/NHLBI P01HL098053Jul 1, 2010 - Jun 30, 2015
      Role: Co-Investigator
      Neural Plasticity During Acclimatization to Hypoxia
      NIH/NHLBI R01HL081823Aug 15, 2005 - Feb 29, 2020
      Role: Principal Investigator
      NIH/NHLBI P01HL017731Feb 1, 1975 - Apr 30, 2006
      Role: Co-Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Smith ZM, Krizay E, Sa RC, Li ET, Scadeng M, Powell F, Dubowitz DJ. Evidence from high altitude acclimatization for an integrated cerebrovascular and ventilatory hypercapnic response, but different responses to hypoxia. J Appl Physiol (1985). 2017 Jul 13; jap.00341.2017. PMID: 28705997.
        View in: PubMed
      2. Powell F. Giants in Chest Medicine: John B. West, MD, PhD, DSc. Chest. 2017 Jul; 152(1):10-12. PMID: 28693761.
        View in: PubMed
      3. Pamenter ME, Carr JA, Go A, Fu Z, Reid SG, Powell F. Glutamate receptors in the nucleus tractus solitarius contribute to ventilatory acclimatization to hypoxia in rat. J Physiol. 2014 Apr 15; 592(8):1839-56. PMID: 24492841; PMCID: PMC4001756.
      4. Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell F, Haddad GG, Yao H. Chemokine receptor-like 2 is involved in ischemic brain injury. J Exp Stroke Transl Med. 2013 Feb 17; 6:1-6. PMID: 23847708.
        View in: PubMed
      5. Powell F, Kou YR. Inflammation and cardio-respiratory control. Foreword. Respir Physiol Neurobiol. 2011 Sep 30; 178(3):359-61. PMID: 21712104.
        View in: PubMed
      6. Powell F. Studying biological responses to global change in atmospheric oxygen. Respir Physiol Neurobiol. 2010 Aug 31; 173 Suppl:S6-12. PMID: 20385257; PMCID: PMC2923684.
      7. Powell F, Fu Z. HIF-1 and ventilatory acclimatization to chronic hypoxia. Respir Physiol Neurobiol. 2008 Dec 10; 164(1-2):282-7. PMID: 18708172; PMCID: PMC2700119.
      8. Powell F. Commentary on: "Major differences in the pulmonary circulation of birds and mammals" by John B. West, Rebecca R. Watson and Zhenxing Fu. Respir Physiol Neurobiol. 2007 Aug 01; 157(2-3):391-2. PMID: 17412654.
        View in: PubMed
      9. Powell F. The influence of chronic hypoxia upon chemoreception. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):154-61. PMID: 17291837; PMCID: PMC1964780.
      10. Powell F. Lake Louise consensus methods for measuring the hypoxic ventilatory response. Adv Exp Med Biol. 2006; 588:271-6. PMID: 17089895.
        View in: PubMed
      11. Powell F, Shams H, Hempleman SC, Mitchell GS. Breathing in thin air: acclimatization to altitude in ducks. Respir Physiol Neurobiol. 2004 Dec 15; 144(2-3):225-35. PMID: 15556105.
        View in: PubMed
      12. Powell F. Functional genomics and the comparative physiology of hypoxia. Annu Rev Physiol. 2003; 65:203-30. PMID: 12471168.
        View in: PubMed
      13. Powell F, Dwinell MR, Aaron EA. Measuring ventilatory acclimatization to hypoxia: comparative aspects. Respir Physiol. 2000 Sep; 122(2-3):271-84. PMID: 10967350.
        View in: PubMed
      14. Powell F, Huey KA, Dwinell MR. Central nervous system mechanisms of ventilatory acclimatization to hypoxia. Respir Physiol. 2000 Jul; 121(2-3):223-36. PMID: 10963777.
        View in: PubMed
      15. Powell F, Garcia N. Physiological effects of intermittent hypoxia. High Alt Med Biol. 2000; 1(2):125-36. PMID: 11256564.
        View in: PubMed
      16. Powell F, Milsom WK, Mitchell GS. Time domains of the hypoxic ventilatory response. Respir Physiol. 1998 May; 112(2):123-34. PMID: 9716296.
        View in: PubMed
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