Loading...

Frank Powell

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentMedicine
Address9500 Gilman Drive #0623-A
La Jolla CA 92093
Phone858-534-1523
vCardDownload vCard
    Other Positions
    TitleChief, Division of Physiology


    Collapse Overview 
    Collapse Overview
    The primary objective or our laboratory in the Division of Physiology is to determine the mechanisms of neural plasticity with hypoxia, which occurs with lung disease and sleep disordered breathing.

    In collaboration with investigators from the Division of Pulmonary and Critical Care Medicine, we focus on the physiological mechanisms of acclimatization to chronic sustained and intermittent hypoxia in the reflexes that control breathing and the cardiovascular system. We study both the genetic determinants of this physiology in healthy humans from sea level and high altitude populations in the Andes and Tibet, and in patients with chronic lung disease. We are especially interested in mechanisms of plasticity in chemoreceptors and respiratory microcircuits in the brain.

    Experimental models in our laboratory include: (1) healthy humans acclimatizing to high altitude and human patients with chronic lung disease and obstructive sleep apnea; (2) conscious, freely moving and behaving rats and transgenic mice using telemetry and chronic physiological instrumentation; (3) neurophysiological preparations and in vivo imaging of cellular and molecular signals for neural plasticity in anesthetized laboratory rodents; (4) computer models of respiratory function.


    Collapse Research 
    Collapse Research Activities and Funding
    Training in the Next Generation in Respiratory Science
    NIH/NHLBI T32HL134632Feb 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Training in Respiratory Biology: Innovate, Integrate, and Translate
    NIH/NHLBI T32HL098062Sep 20, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Molecular mechanisms of hypoxia tolerance and susceptibility
    NIH/NHLBI P01HL098053Jul 1, 2010 - Jun 30, 2015
    Role: Co-Investigator
    Neural Plasticity During Acclimatization to Hypoxia
    NIH/NHLBI R01HL081823Aug 15, 2005 - Feb 29, 2020
    Role: Principal Investigator
    PHYSIOLOGICAL CONSEQUENCES OF PULMONARY DISEASE
    NIH/NHLBI P01HL017731Feb 1, 1975 - Apr 30, 2006
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Naji M, Komarov M, Krishnan GP, Malhotra A, Powell F, Rukhadze I, Fenik VB, Bazhenov M. Computational model of brainstem circuit for state-dependent control of hypoglossal motoneurons. J Neurophysiol. 2018 Apr 04. PMID: 29617218.
      View in: PubMed
    2. Orr JE, Heinrich EC, Djokic M, Gilbertson D, Deyoung PN, Anza-Ramirez C, Villafuerte FC, Powell F, Malhotra A, Simonson T. Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals. High Alt Med Biol. 2018 Mar 13. PMID: 29641294.
      View in: PubMed
    3. Smith ZM, Krizay E, Sá RC, Li ET, Scadeng M, Powell F, Dubowitz DJ. Evidence from high-altitude acclimatization for an integrated cerebrovascular and ventilatory hypercapnic response but different responses to hypoxia. J Appl Physiol (1985). 2017 12 01; 123(6):1477-1486. PMID: 28705997.
      View in: PubMed
    4. Powell F. Giants in Chest Medicine: John B. West, MD, PhD, DSc. Chest. 2017 Jul; 152(1):10-12. PMID: 28693761.
      View in: PubMed
    5. Stokes JA, Arbogast TE, Moya EA, Fu Z, Powell F. Minocycline blocks glial cell activation and ventilatory acclimatization to hypoxia. J Neurophysiol. 2017 Apr 01; 117(4):1625-1635. PMID: 28100653.
      View in: PubMed
    6. Basaran KE, Villongco M, Ho B, Ellis E, Zarndt R, Antonova J, Hopkins SR, Powell F. Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans. PLoS One. 2016; 11(1):e0146087. PMID: 26726885; PMCID: PMC4699648.
    7. Gan Z, Fu Z, Stowe JC, Powell F, McCulloch AD. A Protocol to Collect Specific Mouse Skeletal Muscles for Metabolomics Studies. Methods Mol Biol. 2016; 1375:169-79. PMID: 26003134.
      View in: PubMed
    8. Zarndt R, Piloto S, Powell F, Haddad GG, Bodmer R, Ocorr K. Cardiac responses to hypoxia and reoxygenation in Drosophila. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 01; 309(11):R1347-57. PMID: 26377557; PMCID: PMC4698404 [Available on 12/01/16].
    9. Pamenter ME, Go A, Fu Z, Powell F. No evidence of a role for neuronal nitric oxide synthase in the nucleus tractus solitarius in ventilatory responses to acute or chronic hypoxia in awake rats. J Appl Physiol (1985). 2015 Mar 15; 118(6):750-9. PMID: 25571988; PMCID: PMC4360023.
    10. Pamenter ME, Nguyen J, Carr JA, Powell F. The effect of combined glutamate receptor blockade in the NTS on the hypoxic ventilatory response in awake rats differs from the effect of individual glutamate receptor blockade. Physiol Rep. 2014 Aug 01; 2(8). PMID: 25107985; PMCID: PMC4246593.
    11. Malhotra A, Deacon N, Powell F, Katz ES. Adaptive responses using obstructive sleep apnea as the paradigm. Physiology (Bethesda). 2014 May; 29(3):153-5. PMID: 24789977; PMCID: PMC4888960.
    12. Pamenter ME, Carr JA, Go A, Fu Z, Reid SG, Powell F. Glutamate receptors in the nucleus tractus solitarius contribute to ventilatory acclimatization to hypoxia in rat. J Physiol. 2014 Apr 15; 592(8):1839-56. PMID: 24492841; PMCID: PMC4001756.
    13. Simonson TS, Powell F. Less is more: blunted responses to hypoxia revealed in sea-level Tibetans. J Appl Physiol (1985). 2014 Apr 01; 116(7):711-2. PMID: 24114703.
      View in: PubMed
    14. Pamenter ME, Powell F. Signalling mechanisms of long term facilitation of breathing with intermittent hypoxia. F1000Prime Rep. 2013; 5:23. PMID: 23864930; PMCID: PMC3702218.
    15. Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell F, Haddad GG, Yao H. Chemokine receptor-like 2 is involved in ischemic brain injury. J Exp Stroke Transl Med. 2013 Feb 17; 6:1-6. PMID: 23847708.
      View in: PubMed
    16. Powell F. Measuring the respiratory chemoreflexes in humans by J. Duffin. Respir Physiol Neurobiol. 2012 Apr 15; 181(1):44-5. PMID: 22306918.
      View in: PubMed
    17. Powell F, Kou YR. Inflammation and cardio-respiratory control. Foreword. Respir Physiol Neurobiol. 2011 Sep 30; 178(3):359-61. PMID: 21712104.
      View in: PubMed
    18. Wilkinson KA, Fu Z, Powell F. Ventilatory effects of substance P-saporin lesions in the nucleus tractus solitarii of chronically hypoxic rats. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R343-50. PMID: 21593425; PMCID: PMC3154706.
    19. Popa D, Fu Z, Go A, Powell F. Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats. Respir Physiol Neurobiol. 2011 Sep 30; 178(3):381-6. PMID: 21457799; PMCID: PMC3158279.
    20. Hoshijima M, Hayashi T, Jeon YE, Fu Z, Gu Y, Dalton ND, Ellisman MH, Xiao X, Powell F, Ross J. Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters. Circ Heart Fail. 2011 Jan; 4(1):89-97. PMID: 21036890; PMCID: PMC3742303.
    21. Wilkinson KA, Huey K, Dinger B, He L, Fidone S, Powell F. Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system. J Appl Physiol (1985). 2010 Aug; 109(2):424-30. PMID: 20489036; PMCID: PMC2928595.
    22. Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 05; 11(5):364-78. PMID: 20399150; PMCID: PMC2893150.
    23. Powell F. Studying biological responses to global change in atmospheric oxygen. Respir Physiol Neurobiol. 2010 Aug 31; 173 Suppl:S6-12. PMID: 20385257; PMCID: PMC2923684.
    24. Firth AL, Platoshyn O, Brevnova EE, Burg ED, Powell F, Haddad GH, Yuan JX. Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Ann N Y Acad Sci. 2009 Oct; 1177:101-11. PMID: 19845612.
      View in: PubMed
    25. Powell F, Kim BC, Johnson SR, Fu Z. Oxygen sensing in the brain--invited article. Adv Exp Med Biol. 2009; 648:369-76. PMID: 19536501.
      View in: PubMed
    26. Powell F, Fu Z. HIF-1 and ventilatory acclimatization to chronic hypoxia. Respir Physiol Neurobiol. 2008 Dec 10; 164(1-2):282-7. PMID: 18708172; PMCID: PMC2700119.
    27. Bavis RW, Powell F, Bradford A, Hsia CC, Peltonen JE, Soliz J, Zeis B, Fergusson EK, Fu Z, Gassmann M, Kim CB, Maurer J, McGuire M, Miller BM, O'Halloran KD, Paul RJ, Reid SG, Rusko HK, Tikkanen HO, Wilkinson KA. Respiratory plasticity in response to changes in oxygen supply and demand. Integr Comp Biol. 2007 Oct; 47(4):532-51. PMID: 21672862.
      View in: PubMed
    28. Powell F. Commentary on: "Major differences in the pulmonary circulation of birds and mammals" by John B. West, Rebecca R. Watson and Zhenxing Fu. Respir Physiol Neurobiol. 2007 Aug 01; 157(2-3):391-2. PMID: 17412654.
      View in: PubMed
    29. Powell F. The influence of chronic hypoxia upon chemoreception. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):154-61. PMID: 17291837; PMCID: PMC1964780.
    30. Catron TF, Powell F, West JB. A strategy for determining arterial blood gases on the summit of Mt. Everest. BMC Physiol. 2006 Mar 08; 6:3. PMID: 16524477; PMCID: PMC1421431.
    31. Powell F. Lake Louise consensus methods for measuring the hypoxic ventilatory response. Adv Exp Med Biol. 2006; 588:271-6. PMID: 17089895.
      View in: PubMed
    32. Powell F, Shams H, Hempleman SC, Mitchell GS. Breathing in thin air: acclimatization to altitude in ducks. Respir Physiol Neurobiol. 2004 Dec 15; 144(2-3):225-35. PMID: 15556105.
      View in: PubMed
    33. Hupperets MD, Hopkins SR, Pronk MG, Tiemessen IJ, Garcia N, Wagner PD, Powell F. Increased hypoxic ventilatory response during 8 weeks at 3800 m altitude. Respir Physiol Neurobiol. 2004 Sep 15; 142(2-3):145-52. PMID: 15450476.
      View in: PubMed
    34. Powell F, Hopkins SR. Comparative physiology of lung complexity: implications for gas exchange. News Physiol Sci. 2004 Apr; 19:55-60. PMID: 15016903.
      View in: PubMed
    35. Pronk M, Tiemessen I, Hupperets MD, Kennedy BP, Powell F, Hopkins SR, Wagner PD. Persistence of the lactate paradox over 8 weeks at 3,800 m. High Alt Med Biol. 2003; 4(4):431-43. PMID: 14672546.
      View in: PubMed
    36. Powell F. Functional genomics and the comparative physiology of hypoxia. Annu Rev Physiol. 2003; 65:203-30. PMID: 12471168.
      View in: PubMed
    Frank's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _