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Chantal Darquenne

Title(s)Adjunct Professor, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0623A
La Jolla CA 92093
Phone858-534-9171
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    Collapse Biography 
    Collapse Education and Training
    Université Libre de Bruxelles, BelgiumMSc1990Mechanical Engineering
    Université Libre de Bruxelles, BelgiumPhD1995Applied Sciences

    Collapse Research 
    Collapse Research Activities and Funding
    Multiscale Modeling of Lung Disease-Influenced Aerosol Dosimetry
    NIH/NIEHS U01ES028669Sep 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    MR Imaging of Upper Airway Dynamics in Obstructive Sleep Apnea
    NIH/NHLBI R21HL121794Sep 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Quantitative MRI-based Assessment of Aerosol Deposition in the Lung
    NIH/NHLBI R21HL087805Dec 4, 2007 - Nov 30, 2010
    Role: Principal Investigator
    Modeling of Aerosol Transport in Alveolated Airways
    NIH/NIEHS R01ES011177Aug 1, 2001 - Mar 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deposition Mechanisms. J Aerosol Med Pulm Drug Deliv. 2020 Jun 26. Darquenne C. PMID: 32598200.
      View in: PubMed   Mentions:    Fields:    
    2. Particle Size Distributions. J Aerosol Med Pulm Drug Deliv. 2020 Jun 26. Finlay WH, Darquenne C. PMID: 32598205.
      View in: PubMed   Mentions:    Fields:    
    3. Urgent Appeal from International Society for Aerosols in Medicine (ISAM) During COVID-19: Clinical Decision Makers and Governmental Agencies Should Consider the Inhaled Route of Administration: A Statement from the ISAM Regulatory and Standardization Issues Networking Group. J Aerosol Med Pulm Drug Deliv. 2020 Jun 23. Mitchell JP, Berlinski A, Canisius S, Cipolla D, Dolovich MB, Gonda I, Hochhaus G, Kadrichu N, Lyapustina S, Mansour HM, Darquenne C, Clark AR, Newhouse M, Ehrmann S, Humphries R, Boushey H. PMID: 32589076.
      View in: PubMed   Mentions:    Fields:    
    4. Aerosols and the Human Lung: an Introduction. 2020; 1-211. Chantal Darquenne, Otmar Schmid, G. Kim Prisk.
    5. Innovative preclinical models for pulmonary drug delivery research. Expert Opin Drug Deliv. 2020 Apr; 17(4):463-478. Ehrmann S, Schmid O, Darquenne C, Rothen-Rutishauser B, Sznitman J, Yang L, Barosova H, Vecellio L, Mitchell J, Heuze-Vourc'h N. PMID: 32057260.
      View in: PubMed   Mentions:    Fields:    
    6. The Impact of Lunar Dust on Human Exploration. LPI Contrib. No 2141. What Matters More for Particulate Matter Inhalation in Reduced Gravity: Total Lung Dose or Regional Deposition Pattern?. 2020; 5016.01-5016.02. C. Darquenne, G.K. Prisk.
    7. The Impact of Lunar Dust on Human Exploration. LPI Contrib. No 2141. Setting the Stage for Rapid Assessment of Celestial Dust Toxicity. 2020; 5017.01-5017.02. E.C. Breen, G.K. Prisk, C. Darquenne..
    8. The Effect of Aging on Aerosol Bolus Deposition in the Healthy Adult Lung: A 19-Year Longitudinal Study. J Aerosol Med Pulm Drug Deliv. 2020 Jun; 33(3):133-139. Darquenne C, Prisk GK. PMID: 31613688.
      View in: PubMed   Mentions:    Fields:    
    9. Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent. J Vis Exp. 2019 06 05; (148). Geier ET, Theilmann RJ, Darquenne C, Prisk GK, Sá RC. PMID: 31233033.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Dust in the Atmosphere of Mars and its Impact on Human Exploration. J.S. Levine, D. Winterhalter and R.L. Kerschmann (eds). Reduced Gravity and Aerosol Deposition in the Human Lung. 2018; 175-190. C. Darquenne, G.K. Prisk.
    11. Upper airway dynamic imaging during tidal breathing in awake and asleep subjects with obstructive sleep apnea and healthy controls. Physiol Rep. 2018 05; 6(10):e13711. Darquenne C, Elliott AR, Sibille B, Smales ET, DeYoung PN, Theilmann RJ, Malhotra A. PMID: 29845763.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Pulmonary Delivery of Therapeutic and Diagnostic Gases. J Aerosol Med Pulm Drug Deliv. 2018 04; 31(2):78-87. Zapol WM, Charles HC, Martin AR, Sá RC, Yu B, Ichinose F, MacIntyre N, Mammarappallil J, Moon R, Chen JZ, Geier ET, Darquenne C, Prisk GK, Katz I. PMID: 29451844.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Dust in the Atmosphere of Mars and Its Implications to Human Health. LPI Contrib. No 1966. Reduced gravity and aerosol deposition in the human lung. 2017; 6008.01-6008.03. C. Darquenne, G.K. Prisk.
    14. Regional Ventilation Is the Main Determinant of Alveolar Deposition of Coarse Particles in the Supine Healthy Human Lung During Tidal Breathing. J Aerosol Med Pulm Drug Deliv. 2017 Oct; 30(5):322-331. Sá RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C. PMID: 28277885.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Ventilation heterogeneity measured by multiple breath inert gas testing is not affected by inspired oxygen concentration in healthy humans. J Appl Physiol (1985). 2017 Jun 01; 122(6):1379-1387. Hopkins SR, Elliott AR, Prisk GK, Darquenne C. PMID: 28280107.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Susceptibility to high-altitude pulmonary edema is associated with a more uniform distribution of regional specific ventilation. J Appl Physiol (1985). 2017 Apr 01; 122(4):844-852. Patz MD, Sá RC, Darquenne C, Elliott AR, Asadi AK, Theilmann RJ, Dubowitz DJ, Swenson ER, Prisk GK, Hopkins SR. PMID: 28057815.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. INHALED AEROSOL DOSIMETRY: SOME CURRENT RESEARCH NEEDS. J Aerosol Sci. 2016 Sep; 99:1-5. Darquenne C, Hoover MD, Phalen RF. PMID: 27493295.
      View in: PubMed   Mentions:
    18. Characterizing Lung Disease in Cystic Fibrosis with Magnetic Resonance Imaging and Airway Physiology. PLoS One. 2016; 11(6):e0157177. Theilmann RJ, Darquenne C, Elliott AR, Bailey BA, Conrad DJ. PMID: 27337056.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD. J Aerosol Sci. 2016 Sep; 99:27-39. Darquenne C, Lamm WJ, Fine JM, Corley RA, Glenny RW. PMID: 27493296.
      View in: PubMed   Mentions:
    20. Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung. J Aerosol Med Pulm Drug Deliv. 2016 Apr; 29(2):107-26. Darquenne C, Fleming JS, Katz I, Martin AR, Schroeter J, Usmani OS, Venegas J, Schmid O. PMID: 26829187.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. Effect of Posture on Regional Deposition of Coarse Particles in the Healthy Human Lung. J Aerosol Med Pulm Drug Deliv. 2015 Dec; 28(6):423-31. Sá RC, Zeman KL, Bennett WD, Prisk GK, Darquenne C. PMID: 25826480.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies. J Biomech. 2015 Apr 13; 48(6):1147-57. Oakes JM, Marsden AL, Grandmont C, Darquenne C, Vignon-Clementel IE. PMID: 25682537.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    23. Last Word on Viewpoint: The ongoing need for good physiological investigation: Obstructive sleep apnea in HIV patients as a paradigm. J Appl Physiol (1985). 2015 Jan 15; 118(2):251. Darquenne C, Hicks CB, Malhotra A. PMID: 25593221.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. ISAM Textbook of Aerosol Medicine. R. Dhand (ed). Magnetic Resonance Imaging of Aerosol Deposition. 2015; e1-20. Thompson RB, Darquenne C..
    25. ISAM Textbook of Aerosol Medicine. R. Dhand (ed). Deposition of Aerosols in the Lung: Deposition Mechanisms. 2015; e1-16. Darquenne C..
    26. ISAM Textbook of Aerosol Medicine. R. Dhand (ed). Deposition of Aerosols in the Lungs: Particle size distributions. 2015; e1-8. Finlay WH, Darquenne C..
    27. Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity. J Appl Physiol (1985). 2014 Oct 15; 117(8):880-6. Darquenne C, Borja MG, Oakes JM, Breen EC, Olfert IM, Scadeng M, Prisk GK. PMID: 25170069.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    28. The ongoing need for good physiological investigation: obstructive sleep apnea in HIV patients as a paradigm. J Appl Physiol (1985). 2015 Jan 15; 118(2):244-6. Darquenne C, Hicks CB, Malhotra A. PMID: 25150224.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Aerosol deposition in the human lung in reduced gravity. J Aerosol Med Pulm Drug Deliv. 2014 Jun; 27(3):170-7. Darquenne C. PMID: 24870702.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsPHPublic Health
    30. MRI-based measurements of aerosol deposition in the lung of healthy and elastase-treated rats. J Appl Physiol (1985). 2014 Jun 15; 116(12):1561-8. Oakes JM, Breen EC, Scadeng M, Tchantchou GS, Darquenne C. PMID: 24790020.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    31. Validating the distribution of specific ventilation in healthy humans measured using proton MR imaging. J Appl Physiol (1985). 2014 Apr 15; 116(8):1048-56. Sá RC, Asadi AK, Theilmann RJ, Hopkins SR, Prisk GK, Darquenne C. PMID: 24505099.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    32. Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments. Ann Biomed Eng. 2014 Apr; 42(4):899-914. Oakes JM, Marsden AL, Grandmont C, Shadden SC, Darquenne C, Vignon-Clementel IE. PMID: 24318192.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    33. Cardiogenic mixing increases aerosol deposition in the human lung in the absence of gravity. Acta Astronaut. 2013 Nov; 92(1):15-20. Prisk GK, Sá RC, Darquenne C. PMID: 23976801.
      View in: PubMed   Mentions: 3     Fields:    
    34. Removal of sedimentation decreases relative deposition of coarse particles in the lung periphery. J Appl Physiol (1985). 2013 Aug 15; 115(4):546-55. Darquenne C, Zeman KL, Sá RC, Cooper TK, Fine JM, Bennett WD, Prisk GK. PMID: 23743403.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Particulate deposition in the human lung under lunar habitat conditions. Aviat Space Environ Med. 2013 Mar; 84(3):190-5. Darquenne C, Prisk GK. PMID: 23513279.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging. Ann Biomed Eng. 2013 May; 41(5):967-78. Oakes JM, Scadeng M, Breen EC, Prisk GK, Darquenne C. PMID: 23354670.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    37. Proceedings of the ASME 2012 Summer Bioengineering Conference. Multiscale model of airflow in healthy and emphysema rat lungs. 2012; SBC2012:1263-1264. Oakes, J.M., A.L. Marsden, C. Grandmont, S. Shadden, C. Darquenne, and I.E. Vignon-Clementel.
    38. Aerosol bolus dispersion in acinar airways--influence of gravity and airway asymmetry. J Appl Physiol (1985). 2012 Aug; 113(3):442-50. Ma B, Darquenne C. PMID: 22678957.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    39. Aerosol deposition in health and disease. J Aerosol Med Pulm Drug Deliv. 2012 Jun; 25(3):140-7. Darquenne C. PMID: 22686623.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    40. Rat airway morphometry measured from in situ MRI-based geometric models. J Appl Physiol (1985). 2012 Jun; 112(11):1921-31. Oakes JM, Scadeng M, Breen EC, Marsden AL, Darquenne C. PMID: 22461437.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    41. Convective flow dominates aerosol delivery to the lung segments. J Appl Physiol (1985). 2011 Jul; 111(1):48-54. Darquenne C, van Ertbruggen C, Prisk GK. PMID: 21474695.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    42. Aerosol deposition characteristics in distal acinar airways under cyclic breathing conditions. J Appl Physiol (1985). 2011 May; 110(5):1271-82. Ma B, Darquenne C. PMID: 21330617.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    43. Proceedings of the ASME 2010 Summer Bioengineering Conference. Image-based morphometry and airflow simulation in rat lungs. 2010; SBC2010:655-656. Oakes, J.M., A.L. Marsden, M. Scadeng, and C. Darquenne..
    44. Ventilation-perfusion inequality in the human lung is not increased following no-decompression-stop hyperbaric exposure. Eur J Appl Physiol. 2009 Nov; 107(5):545-52. Moore GS, Wong SC, Darquenne C, Neuman TS, West JB, Kim Prisk G. PMID: 19690884.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    45. Alveolar duct expansion greatly enhances aerosol deposition: a three-dimensional computational fluid dynamics study. Philos Trans A Math Phys Eng Sci. 2009 Jun 13; 367(1896):2333-46. Darquenne C, Harrington L, Prisk GK. PMID: 19414458.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    46. CFD Simulation and Experimental Validation of Fluid Flow and Particle Transport in a Model of Alveolated Airways. J Aerosol Sci. 2009 May; 40(5):403-141. Ma B, Ruwet V, Corieri P, Theunissen R, Riethmuller M, Darquenne C. PMID: 20161301.
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    47. Proceedings of the 14th International Symposium on Applications of Laser Techniques to Fluid Mechanics. Flow of aerosol in 3D alveolated bifurcations: experimental measurements by Particle Image Velocimetry (PIV) and Particle Tracking Velocimetry (PTV). 2008; Paper No 1459, pp 1-12.. Ruwet, V., P. Corieri, R. Theunissen, B. Ma, M.L. Riethmuller, and C. Darquenne..
    48. Aerosol deposition in the human lung periphery is increased by reduced-density gas breathing. J Aerosol Med Pulm Drug Deliv. 2008 Jun; 21(2):159-68. Peterson JB, Prisk GK, Darquenne C. PMID: 18518792.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    49. Deposition of inhaled particles in the human lung is more peripheral in lunar than in normal gravity. Eur J Appl Physiol. 2008 Aug; 103(6):687-95. Darquenne C, Prisk GK. PMID: 18488244.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    50. Validation of CFD predictions of flow in a 3D alveolated bend with experimental data. J Biomech. 2008; 41(2):399-405. van Ertbruggen C, Corieri P, Theunissen R, Riethmuller ML, Darquenne C. PMID: 17915225.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    51. Proceedings of the 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics. Experimental investigation of aerosol deposition in alveolar lung airways. 2006; Paper No 1098, pp1-12. Theunissen R., N. Buchmann, P. Corieri, M.L. Riethmuller, and C. Darquenne..
    52. Importance of the bifurcation zone and branch orientation in simulated aerosol deposition in the alveolar zone of the human lung. Journal of Aerosol Science. 2006; 37:37-62. Harrington L, Prisk GK, Darquenne C..
    53. Encyclopedia of Respiratory Medicine. Laurent GJ, Shapiro SD, editors. Particle deposition in the lung. 2006; 300-303. Darquenne C..
    54. Aerosols in the study of convective acinar mixing. Respir Physiol Neurobiol. 2005 Aug 25; 148(1-2):207-16. Darquenne C, Prisk GK. PMID: 15890563.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    55. Airway closure in microgravity. Respir Physiol Neurobiol. 2005 Aug 25; 148(1-2):97-111. Dutrieue B, Verbanck S, Darquenne C, Prisk GK. PMID: 15979418.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. Effect of small flow reversals on aerosol mixing in the alveolar region of the human lung. J Appl Physiol (1985). 2004 Dec; 97(6):2083-9. Darquenne C, Prisk GK. PMID: 15298988.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    57. Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox. J Aerosol Med. 2004; 17(3):278-85. Darquenne C, Prisk GK. PMID: 15625820.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    58. Effect of gravitational sedimentation on simulated aerosol dispersion in the human acinus. J Aerosol Sci. 2003 Apr; 34(4):405-18. Darquenne C, Prisk GK. PMID: 12747364.
      View in: PubMed   Mentions:
    59. Tidal volume single-breath washin of SF6 and CH4 in transient microgravity. J Appl Physiol (1985). 2003 Jan; 94(1):75-82. Dutrieue B, Paiva M, Verbanck S, Le Gouic M, Darquenne C, Prisk GK. PMID: 12391087.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    60. Mode shift of an inhaled aerosol bolus is correlated with flow sequencing in the human lung. J Appl Physiol (1985). 2002 Mar; 92(3):1232-8. Mills CN, Darquenne C, Prisk GK. PMID: 11842063.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    61. Heterogeneity of aerosol deposition in a two-dimensional model of human alveolated airways. Journal of Aerosol Science. 2002; 33:1261-1278. Darquenne C..
    62. Gravity and the Lung: Lessons from Microgravity. Prisk GK, Paiva M, West JB, editors. Chapter 5: Aerosol Transport in the Lung. 2001; 117-148. Darquenne C..
    63. A realistic two-dimensional model of aerosol transport and deposition in the alveolar zone of the human lung. Journal of Aerosol Science. 2001; 32:1161-1174. Darquenne C..
    64. Effect of gravity on aerosol dispersion and deposition in the human lung after periods of breath holding. J Appl Physiol (1985). 2000 Nov; 89(5):1787-92. Darquenne C, Paiva M, Prisk GK. PMID: 11053327.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCTClinical Trials
    65. Dispersion of 0.5- to 2-micron aerosol in microG and hypergravity as a probe of convective inhomogeneity in the lung. J Appl Physiol (1985). 1999 Apr; 86(4):1402-9. Darquenne C, West JB, Prisk GK. PMID: 10194229.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    66. A source of experimental underestimation of aerosol bolus deposition. J Appl Physiol (1985). 1999 Mar; 86(3):1067-74. Verbanck S, Darquenne C, Prisk GK, Vincken W, Paiva M. PMID: 10066725.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    67. Deposition and dispersion of 1-micrometer aerosol boluses in the human lung: effect of micro- and hypergravity. J Appl Physiol (1985). 1998 Oct; 85(4):1252-9. Darquenne C, West JB, Prisk GK. PMID: 9760313.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    68. Complexities in Structure and Function of the Lung. Hlastala MP, Robertson HT, editors. Chapter 10: Gas and Particle Transport in the Lung. 1998; 297-323. Darquenne C, Paiva M.
    69. Effect of microgravity and hypergravity on deposition of 0.5- to 3-micron-diameter aerosol in the human lung. J Appl Physiol (1985). 1997 Dec; 83(6):2029-36. Darquenne C, Paiva M, West JB, Prisk GK. PMID: 9390977.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsCTClinical Trials
    70. Aerosol dispersion in human lung: comparison between numerical simulations and experiments for bolus tests. J Appl Physiol (1985). 1997 Sep; 83(3):966-74. Darquenne C, Brand P, Heyder J, Paiva M. PMID: 9292486.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    71. Two- and three-dimensional simulations of aerosol transport and deposition in alveolar zone of human lung. J Appl Physiol (1985). 1996 Apr; 80(4):1401-14. Darquenne C, Paiva M. PMID: 8926273.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    72. One-dimensional simulation of aerosol transport and deposition in the human lung. J Appl Physiol (1985). 1994 Dec; 77(6):2889-98. Darquenne C, Paiva M. PMID: 7896637.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
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