Susan Taylor

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Structural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar Ataxia
    NIH R01NS120725May 1, 2021 - Mar 31, 2026
    Role: Co-Principal Investigator
    Illuminating the Role of understudied PRKACB Splice Variants in PKA Signaling
    NIH R03TR002947Sep 1, 2019 - Aug 31, 2020
    Role: Principal Investigator
    Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
    NIH R35GM130389Jan 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    San Diego Center for Systems Biology: From Maps to Models
    NIH P50GM085764Sep 18, 2010 - May 31, 2019
    Role: Co-Investigator
    ASSEMBLY OF SIGNALING NETWORKS
    NIH R13DK057994Mar 20, 2000 - Feb 28, 2001
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH P01DK054441Dec 15, 1998 - Mar 31, 2019
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    MOLECULAR BIOPHYSICS TRAINING PROGRAM
    NIH T32GM008326Jul 1, 1989 - Jun 30, 2021
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    GORDON RESEARCH CONFERENCE ON SECOND MESSENGERS
    NIH R13GM036850Jun 23, 1986 - May 31, 1987
    Role: Principal Investigator
    Assembly and regulation of dynamic PKA macromolecular signaling systems
    NIH R01GM034921Sep 25, 1985 - May 31, 2019
    Role: Principal Investigator
    Protein Kinase - Primary Structure and cAMP Interaction
    NIH R01GM019301May 1, 1978 - Nov 30, 2014
    Role: Principal Investigator
    PROTEIN KINASE: PRIMARY STRUCTURE AND CAMP INTERACTION
    NIH R37GM019301May 1, 1978 - Apr 30, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Presumptive motor neuron degeneration in an adult cat. Can Vet J. 2024 Oct; 65(10):1034-1040. Leger D, Bater S, Paulin MV, Linn K, Taylor S, Shelton GD. PMID: 39355693; PMCID: PMC11411472.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. Elife. 2024 Jun 24; 12. Olivieri C, Wang Y, Walker C, Subrahmanian MV, Ha KN, Bernlohr D, Gao J, Camilloni C, Vendruscolo M, Taylor SS, Veglia G. PMID: 38913408; PMCID: PMC11196109.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    3. RedOx regulation of LRRK2 kinase activity by active site cysteines. NPJ Parkinsons Dis. 2024 Apr 03; 10(1):75. Trilling CR, Weng JH, Sharma PK, Nolte V, Wu J, Ma W, Boassa D, Taylor SS, Herberg FW. PMID: 38570484; PMCID: PMC10991482.
      View in: PubMed   Mentions: 1  
    4. How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex. Cell Rep. 2024 Apr 23; 43(4):114011. Jones AC, Wu J, Taylor SS. PMID: 38573854.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Molecular determinants and signaling effects of PKA RIα phase separation. Mol Cell. 2024 Apr 18; 84(8):1570-1584.e7. Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, Zhang J. PMID: 38537638; PMCID: PMC11031308.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk. Biochem J. 2024 Feb 21; 481(4):313-327. Sharma PK, Weng JH, Manschwetus JT, Wu J, Ma W, Herberg FW, Taylor SS. PMID: 38305364; PMCID: PMC10903466.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Corrigendum to "Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order-Disorder Transition Upon Activation" [J. Mol. Biol. 435(12) (2023) 1-17]. J Mol Biol. 2024 Mar 15; 436(6):168485. Weng JH, Trilling CR, Kaila Sharma P, Störmer E, Wu J, Herberg FW, Taylor SS. PMID: 38369414.
      View in: PubMed   Mentions:    Fields:    
    8. Gauging Dynamics-driven Allostery Using a New Computational Tool: A CAP Case Study. J Mol Biol. 2024 01 15; 436(2):168395. Kornev AP, Weng JH, Maillard RA, Taylor SS. PMID: 38097109; PMCID: PMC10851786.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. Molecular Determinants and Signaling Effects of PKA RIα Phase Separation. bioRxiv. 2023 Dec 11. Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, Zhang J. PMID: 38168176; PMCID: PMC10760030.
      View in: PubMed   Mentions:
    10. Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop. bioRxiv. 2023 Oct 16. Wu J, Jonniya NA, Hirakis SP, Olivieri C, Veglia G, Kornev AP, Taylor SS. PMID: 37693538; PMCID: PMC10491255.
      View in: PubMed   Mentions:
    11. The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. bioRxiv. 2023 Sep 15. Olivieri C, Wang Y, Walker C, Subrahmanian MV, Ha KN, Bernlohr DA, Gao J, Camilloni C, Vendruscolo M, Taylor SS, Veglia G. PMID: 37745542; PMCID: PMC10515842.
      View in: PubMed   Mentions:
    12. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. Biochem J. 2023 08 30; 480(16):1299-1316. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 37551632; PMCID: PMC10586763.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors. ACS Chem Biol. 2023 04 21; 18(4):810-821. Weng JH, Ma W, Wu J, Sharma PK, Silletti S, McCammon JA, Taylor S. PMID: 37043829; PMCID: PMC10127209.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Do perineuronal nets stabilize the engram of a synaptic circuit? bioRxiv. 2023 Apr 09. Lev-Ram V, Lemieux SP, Deerinck TJ, Bushong EA, Toyama BH, Perez A, Pritchard DR, Park SKR, McClatchy DB, Savas JN, Taylor SS, Ellisman MH, Yates J, Tsien RY. PMID: 37066274; PMCID: PMC10104172.
      View in: PubMed   Mentions:
    15. An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP-dependent protein kinase A. FEBS Lett. 2023 04; 597(8):1055-1072. Olivieri C, Walker C, Veliparambil Subrahmanian M, Porcelli F, Taylor SS, Bernlohr DA, Veglia G. PMID: 36892429; PMCID: PMC11334100.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. bioRxiv. 2023 Mar 16. Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. PMID: 36993163; PMCID: PMC10055082.
      View in: PubMed   Mentions:
    17. The "violin model": Looking at community networks for dynamic allostery. J Chem Phys. 2023 Feb 28; 158(8):081001. Madan LK, Welsh CL, Kornev AP, Taylor SS. PMID: 36859094; PMCID: PMC9957607.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A. IUBMB Life. 2023 04; 75(4):311-323. Taylor SS, Herberg FW, Veglia G, Wu J. PMID: 36855225; PMCID: PMC10050139.
      View in: PubMed   Mentions: 2     Fields:    
    19. Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order-Disorder Transition Upon Activation. J Mol Biol. 2023 06 15; 435(12):167999. Weng JH, Trilling CR, Kaila Sharma P, Störmer E, Wu J, Herberg FW, Taylor SS. PMID: 36764356.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    20. Molecular-dynamics simulation methods for macromolecular crystallography. Acta Crystallogr D Struct Biol. 2023 Jan 01; 79(Pt 1):50-65. Wych DC, Aoto PC, Vu L, Wolff AM, Mobley DL, Fraser JS, Taylor SS, Wall ME. PMID: 36601807; PMCID: PMC9815100.
      View in: PubMed   Mentions: 7  Translation:Cells
    21. Calculation of centralities in protein kinase A. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2215420119. Kornev AP, Aoto PC, Taylor SS. PMID: 36375071; PMCID: PMC9704751.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    22. A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction. Nat Struct Mol Biol. 2022 10; 29(10):990-999. Happ JT, Arveseth CD, Bruystens J, Bertinetti D, Nelson IB, Olivieri C, Zhang J, Hedeen DS, Zhu JF, Capener JL, Bröckel JW, Vu L, King CC, Ruiz-Perez VL, Ge X, Veglia G, Herberg FW, Taylor SS, Myers BR. PMID: 36202993; PMCID: PMC9696579.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    23. Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Sci Signal. 2022 Sep 27; 15(753):eabk1147. Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, Newton AC. PMID: 36166510; PMCID: PMC9810342.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy. Sci Adv. 2022 Jul 29; 8(30):eabo0696. Olivieri C, Li GC, Wang Y, V S M, Walker C, Kim J, Camilloni C, De Simone A, Vendruscolo M, Bernlohr DA, Taylor SS, Veglia G. PMID: 35905186; PMCID: PMC9337769.
      View in: PubMed   Mentions: 9     Fields:    
    25. Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses. J Biol Chem. 2022 08; 298(8):102245. Thomas R, Hernandez A, Benavides DR, Li W, Tan C, Umfress A, Plattner F, Chakraborti A, Pozzo-Miller L, Taylor SS, Bibb JA. PMID: 35835216; PMCID: PMC9386499.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    26. LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS Biol. 2022 02; 20(2):e3001427. Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS. PMID: 35192607; PMCID: PMC8863276.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    27. A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host. Nat Commun. 2022 01 25; 13(1):472. Alexa A, Sok P, Gross F, Albert K, Kobori E, Póti ÁL, Gógl G, Bento I, Kuang E, Taylor SS, Zhu F, Ciliberto A, Reményi A. PMID: 35078976; PMCID: PMC8789800.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    28. A tribute to Eddy Fischer (April 6, 1920-August 27, 2021): Passionate biochemist and mentor. Proc Natl Acad Sci U S A. 2022 01 18; 119(3). Taylor SS, Hunter T, Changeux JP. PMID: 35042780; PMCID: PMC8784095.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    29. Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits. Front Mol Neurosci. 2021; 14:782041. Roa JN, Ma Y, Mikulski Z, Xu Q, Ilouz R, Taylor SS, Skowronska-Krawczyk D. PMID: 34867193; PMCID: PMC8636463.
      View in: PubMed   Mentions: 5  
    30. Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling. Pharmacol Rev. 2021 10; 73(4):155-197. Ramms DJ, Raimondi F, Arang N, Herberg FW, Taylor SS, Gutkind JS. PMID: 34663687; PMCID: PMC11060502.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    31. Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics. Biochemistry. 2021 11 23; 60(46):3470-3484. Lorenz R, Wu J, Herberg FW, Taylor SS, Engh RA. PMID: 34370450.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    32. The Tails of Protein Kinase A. Mol Pharmacol. 2022 04; 101(4):219-225. Taylor SS, Søberg K, Kobori E, Wu J, Pautz S, Herberg FW, Skålhegg BS. PMID: 34330820; PMCID: PMC9092481.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A? J Mol Biol. 2021 09 03; 433(18):167123. Walker C, Wang Y, Olivieri C, V S M, Gao J, Bernlohr DA, Calebiro D, Taylor SS, Veglia G. PMID: 34224748; PMCID: PMC8409435.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies. Biochem J. 2021 06 11; 478(11):2101-2119. Taylor SS, Wallbott M, Machal EMF, Søberg K, Ahmed F, Bruystens J, Vu L, Baker B, Wu J, Raimondi F, Ongeri EM, Herberg FW, Skålhegg BS. PMID: 34115095.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    35. Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. PMID: 34088839; PMCID: PMC8201809.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    36. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). Jafari N, Del Rio J, Akimoto M, Byun JA, Boulton S, Moleschi K, Alsayyed Y, Swanson P, Huang J, Martinez Pomier K, Lee C, Wu J, Taylor SS, Melacini G. PMID: 34006641; PMCID: PMC8166182.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. From structure to the dynamic regulation of a molecular switch: A journey over 3 decades. J Biol Chem. 2021 Jan-Jun; 296:100746. Taylor SS, Wu J, Bruystens JGH, Del Rio JC, Lu TW, Kornev AP, Ten Eyck LF. PMID: 33957122; PMCID: PMC8144671.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    38. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 04 13; 14(678). Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. PMID: 33850054; PMCID: PMC8208635.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    39. Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Commun Biol. 2021 Apr 06; 4(1):446. Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu VS, Porcelli F, Blumenthal DK, Thomas DD, Bernlohr DA, Simon SM, Taylor SS, Veglia G. PMID: 33824409; PMCID: PMC8024247.
      View in: PubMed   Mentions:
    40. Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Commun Biol. 2021 03 10; 4(1):321. Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu VS, Porcelli F, Blumenthal DK, Thomas DD, Bernlohr DA, Simon SM, Taylor SS, Veglia G. PMID: 33692454; PMCID: PMC7946884.
      View in: PubMed   Mentions: 14  Translation:HumansCells
    41. Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. PLoS Biol. 2020 12; 18(12):e3001018. Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. PMID: 33370777; PMCID: PMC7793292.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes. IUBMB Life. 2020 12; 72(12):2584-2590. Jones AC, Taylor SS, Newton AC, Kornev AP. PMID: 33166426; PMCID: PMC8086893.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    43. Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. Am J Hum Genet. 2020 11 05; 107(5):977-988. Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, Hildebrand MS, Coleman M, Bahlo M, Bennett MF, Schneider AL, Scheffer IE, Kibæk M, Kristiansen BS, Issa MY, Mehrez MI, Ismail S, Tenorio J, Li G, Skålhegg BS, Otaify GA, Temtamy S, Aglan M, Jønch AE, De Luca A, Mortier G, Cormier-Daire V, Ziegler A, Wallis M, Lapunzina P, Herberg FW, Taylor SS, Ruiz-Perez VL. PMID: 33058759; PMCID: PMC7675002.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    44. Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery. Front Mol Neurosci. 2020; 13:538219. Taylor SS, Kaila-Sharma P, Weng JH, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW. PMID: 33122997; PMCID: PMC7573214.
      View in: PubMed   Mentions: 9  
    45. Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling. Cell. 2020 09 17; 182(6):1531-1544.e15. Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J. PMID: 32846158; PMCID: PMC7502557.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    46. The In Situ Structure of Parkinson's Disease-Linked LRRK2. Cell. 2020 09 17; 182(6):1508-1518.e16. Watanabe R, Buschauer R, Böhning J, Audagnotto M, Lasker K, Lu TW, Boassa D, Taylor S, Villa E. PMID: 32783917; PMCID: PMC7869717.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    47. Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A. Elife. 2020 04 27; 9. Olivieri C, Wang Y, Li GC, V S M, Kim J, Stultz BR, Neibergall M, Porcelli F, Muretta JM, Thomas DD, Gao J, Blumenthal DK, Taylor SS, Veglia G. PMID: 32338601; PMCID: PMC7234811.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    48. Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons. Methods Enzymol. 2020; 634:311-331. Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A. PMID: 32093838; PMCID: PMC7494206.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    49. Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1231-H1242. Haushalter KJ, Schilling JM, Song Y, Sastri M, Perkins GA, Strack S, Taylor SS, Patel HH. PMID: 31674811; PMCID: PMC6962616.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    50. Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains. Nat Commun. 2019 09 04; 10(1):3984. Hao Y, England JP, Bellucci L, Paci E, Hodges HC, Taylor SS, Maillard RA. PMID: 31484930; PMCID: PMC6726620.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    51. Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity. Sci Adv. 2019 08; 5(8):eaaw9298. Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K, Calebiro D, Gao J, Bernlohr DA, Taylor SS, Veglia G. PMID: 31489371; PMCID: PMC6713507.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    52. BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS. Sci Adv. 2019 08; 5(8):eaav8463. Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E. PMID: 31453322; PMCID: PMC6693913.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    53. Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16347-16356. Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. PMID: 31363049; PMCID: PMC6697891.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    54. The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):14979-14988. Schmidt SH, Knape MJ, Boassa D, Mumdey N, Kornev AP, Ellisman MH, Taylor SS, Herberg FW. PMID: 31292254; PMCID: PMC6660771.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    55. Dynamic allostery-based molecular workings of kinase:peptide complexes. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15052-15061. Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. PMID: 31285328; PMCID: PMC6660753.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    56. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 2019 05 21; 8. Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. PMID: 31112131; PMCID: PMC6529218.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    57. Tuning the "violin" of protein kinases: The role of dynamics-based allostery. IUBMB Life. 2019 06; 71(6):685-696. Ahuja LG, Taylor SS, Kornev AP. PMID: 31063633; PMCID: PMC6690483.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    58. Evolution of a dynamic molecular switch. IUBMB Life. 2019 06; 71(6):672-684. Taylor SS, Meharena HS, Kornev AP. PMID: 31059206; PMCID: PMC6690480.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    59. Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα. Structure. 2019 05 07; 27(5):816-828.e4. Cao B, Lu TW, Martinez Fiesco JA, Tomasini M, Fan L, Simon SM, Taylor SS, Zhang P. PMID: 30905674; PMCID: PMC6506387.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    60. Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex. Sci Adv. 2019 03; 5(3):eaav0482. Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A. PMID: 30906862; PMCID: PMC6426457.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    61. Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nat Commun. 2019 02 18; 10(1):799. Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. PMID: 30778078; PMCID: PMC6379427.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    62. Crystal structure of the WD40 domain dimer of LRRK2. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1579-1584. Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H. PMID: 30635421; PMCID: PMC6358694.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    63. Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores. Trends Biochem Sci. 2019 04; 44(4):300-311. Gógl G, Kornev AP, Reményi A, Taylor SS. PMID: 30611608; PMCID: PMC6592696.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    64. cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. J Biol Chem. 2019 02 15; 294(7):2232-2246. Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J. PMID: 30530493; PMCID: PMC6378977.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    65. Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889. J Mol Biol. 2018 Oct 19; 430(21):4439. Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. PMID: 30220583; PMCID: PMC11406633.
      View in: PubMed   Mentions:    Fields:    
    66. Kinase domain dimerization drives RIPK3-dependent necroptosis. Sci Signal. 2018 08 21; 11(544). Raju S, Whalen DM, Mengistu M, Swanson C, Quinn JG, Taylor SS, Webster JD, Newton K, Shaw AS. PMID: 30131368; PMCID: PMC6310155.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    67. AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. J Neurosci. 2018 09 19; 38(38):8233-8242. Flippo KH, Gnanasekaran A, Perkins GA, Ajmal A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM, Strack S. PMID: 30093535; PMCID: PMC6146498.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    68. Switching of the folding-energy landscape governs the allosteric activation of protein kinase A. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):E7478-E7485. England JP, Hao Y, Bai L, Glick V, Hodges HC, Taylor SS, Maillard RA. PMID: 30038016; PMCID: PMC6094112.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    69. A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. J Mol Biol. 2018 03 16; 430(6):881-889. Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. PMID: 29410316; PMCID: PMC6279248.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    70. Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem. 2018 03 23; 293(12):4411-4421. Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS. PMID: 29378851; PMCID: PMC5868259.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    71. Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma. Sci Rep. 2018 01 15; 8(1):720. Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor SS, Veglia G, Simon SM. PMID: 29335433; PMCID: PMC5768683.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    72. Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E428-E437. Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS. PMID: 29282319; PMCID: PMC5776975.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    73. The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides. Biochimie. 2018 Mar; 146:166-180. Bubis J, Martínez JC, Calabokis M, Ferreira J, Sanz-Rodríguez CE, Navas V, Escalona JL, Guo Y, Taylor SS. PMID: 29288679; PMCID: PMC6550279.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    74. Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Sci Rep. 2017 09 07; 7(1):10843. Hao Y, Canavan C, Taylor SS, Maillard RA. PMID: 28883488; PMCID: PMC5589850.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    75. Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. J Cell Sci. 2017 Oct 01; 130(19):3248-3260. Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA. PMID: 28808085; PMCID: PMC5665436.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    76. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G. PMID: 28435869; PMCID: PMC5384802.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    77. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα. Biochemistry. 2017 03 14; 56(10):1536-1545. P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE. PMID: 28221775; PMCID: PMC5495472.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    78. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):E931-E940. Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. PMID: 28115705; PMCID: PMC5307475.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    79. Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife. 2017 01 12; 6. Ilouz R, Lev-Ram V, Bushong EA, Stiles TL, Friedmann-Morvinski D, Douglas C, Goldberg JL, Ellisman MH, Taylor SS. PMID: 28079521; PMCID: PMC5300705.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    80. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol. 2016 Nov; 14(11):e2000127. Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor SS. PMID: 27902690; PMCID: PMC5130182.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    81. Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J Mol Biol. 2016 12 04; 428(24 Pt B):4890-4904. Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor SS. PMID: 27825928; PMCID: PMC5149412.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    82. Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. J Am Anim Hosp Assoc. 2016 Nov/Dec; 52(6):364-370. Taylor S, Minor K, Shmon CL, Shelton GD, Patterson EE, Mickelson JR. PMID: 27685362.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    83. Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols. J Am Anim Hosp Assoc. 2016 Sep-Oct; 52(5):281-90. Taylor S, Shmon C, Su L, Epp T, Minor K, Mickelson J, Patterson E, Shelton GD. PMID: 27487345.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    84. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7786-91. Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E. PMID: 27357676; PMCID: PMC4948347.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    85. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. FEBS J. 2016 06; 283(11):2132-48. Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor SS, Heck AJ, Scholten A. PMID: 27028580; PMCID: PMC4980077.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    86. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure. 2016 Mar 01; 24(3):353-63. Kim J, Li G, Walters MA, Taylor SS, Veglia G. PMID: 26833386; PMCID: PMC4775281.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    87. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem. 2016 Mar 18; 291(12):6182-99. Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. PMID: 26797121; PMCID: PMC4813559.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    88. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 26748707; PMCID: PMC4831919.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    89. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα. PLoS Biol. 2015; 13(11):e1002305. Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G. PMID: 26618408; PMCID: PMC4664472.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    90. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-647. Kornev AP, Taylor SS. PMID: 26481499; PMCID: PMC4630092.
      View in: PubMed   Mentions: 118     Fields:    Translation:Cells
    91. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12681-6. Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS. PMID: 26417071; PMCID: PMC4611605.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    92. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-1572. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. PMID: 26278174; PMCID: PMC4558360.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    93. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Rep. 2015 Aug 25; 12(8):1252-60. Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. PMID: 26279568; PMCID: PMC4551583.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    94. Divalent Metal Ions Mg²⁺ and Ca²⁺ Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol. 2015 Oct 16; 10(10):2303-15. Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor SS, Herberg FW. PMID: 26200257; PMCID: PMC4714867.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    95. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. PMID: 26203188; PMCID: PMC4571978.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    96. Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. PMID: 26158466; PMCID: PMC4497662.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    97. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. PMID: 26145448; PMCID: PMC4504738.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    98. Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry. 2015 Jul 07; 54(26):4042-9. Li GC, Srivastava AK, Kim J, Taylor SS, Veglia G. PMID: 26030372; PMCID: PMC4498444.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    99. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. Zhang P, Kornev AP, Wu J, Taylor SS. PMID: 26097522; PMCID: PMC4469037.
      View in: PubMed   Mentions: 12  
    100. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS. PMID: 25961504; PMCID: PMC4449815.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    101. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J. PMID: 25893917; PMCID: PMC4452027.
      View in: PubMed   Mentions: 438     Fields:    Translation:HumansAnimalsCells
    102. Integration of signaling in the kinome: Architecture and regulation of the αC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. Taylor SS, Shaw AS, Kannan N, Kornev AP. PMID: 25891902; PMCID: PMC4577442.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    103. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1575-85. Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N. PMID: 25847873; PMCID: PMC4577300.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    104. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3716-21. Kim J, Masterson LR, Cembran A, Verardi R, Shi L, Gao J, Taylor SS, Veglia G. PMID: 25775607; PMCID: PMC4378435.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    105. ProKinO: a unified resource for mining the cancer kinome. Hum Mutat. 2015 Feb; 36(2):175-86. McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor SS, Kochut K, Kannan N. PMID: 25382819; PMCID: PMC4342772.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    106. D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Sci. 2015 Jan; 24(1):105-16. Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA, Taylor SS. PMID: 25348485; PMCID: PMC4282416.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    107. Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure. 2014 Dec 02; 22(12):1735-1743. Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL, Taylor SS, Veglia G. PMID: 25458836; PMCID: PMC4255147.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    108. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. Am J Physiol Renal Physiol. 2015 Jan 01; 308(1):F56-68. Niyitegeka JM, Bastidas AC, Newman RH, Taylor SS, Ongeri EM. PMID: 25354939; PMCID: PMC4281694.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    109. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. PMID: 25348715; PMCID: PMC4295384.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    110. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. McClendon CL, Kornev AP, Gilson MK, Taylor SS. PMID: 25319261; PMCID: PMC4217441.
      View in: PubMed   Mentions: 120     Fields:    Translation:Cells
    111. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. Boras BW, Kornev A, Taylor SS, McCulloch AD. PMID: 25202018; PMCID: PMC4208011.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    112. The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study. J Biol Chem. 2014 Oct 10; 289(41):28505-12. Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor SS. PMID: 25112875; PMCID: PMC4192500.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    113. Molecular features of product release for the PKA catalytic cycle. Biochemistry. 2015 Jan 13; 54(1):2-10. Bastidas AC, Wu J, Taylor SS. PMID: 25077557; PMCID: PMC4295794.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    114. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor SS, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J. PMID: 24687277; PMCID: PMC3971754.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    115. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. PMID: 24567368; PMCID: PMC3993607.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    116. Allosteric linkers in cAMP signalling. Biochem Soc Trans. 2014 Feb; 42(1):139-44. Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G. PMID: 24450641; PMCID: PMC5100742.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    117. PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor SS. PMID: 24316401; PMCID: PMC3963464.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    118. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. PMID: 24143133; PMCID: PMC3797032.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    119. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor SS, Dillmann WH, Goldhaber JI, Ross RS. PMID: 24091324; PMCID: PMC3784521.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    120. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. PMID: 24030101; PMCID: PMC3861721.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    121. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. ACS Chem Biol. 2013 Oct 18; 8(10):2164-72. Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. PMID: 23978166; PMCID: PMC3827627.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    122. Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry. 2013 Sep 17; 52(37):6368-79. Bastidas AC, Pierce LC, Walker RC, Johnson DA, Taylor SS. PMID: 24003983; PMCID: PMC3788587.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    123. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-1046. Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS. PMID: 23993095; PMCID: PMC3844432.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    124. Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14231-6. Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. PMID: 23946424; PMCID: PMC3761587.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    125. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. PMID: 23863167; PMCID: PMC4399968.
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    126. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol. 2013 Oct; 163(2):504-13. Laanemets K, Brandt B, Li J, Merilo E, Wang YF, Keshwani MM, Taylor SS, Kollist H, Schroeder JI. PMID: 23766366; PMCID: PMC3793032.
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    127. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013 Jun 01; 27(11):1223-32. Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. PMID: 23752589; PMCID: PMC3690396.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    128. The fractalkine/CX3CR1 system regulates β cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. PMID: 23582329; PMCID: PMC3717389.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    129. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. Taylor SS, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PMID: 23535202; PMCID: PMC3763834.
      View in: PubMed   Mentions: 140     Fields:    Translation:Cells
    130. Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc. 2013 Mar 27; 135(12):4788-98. Bastidas AC, Deal MS, Steichen JM, Guo Y, Wu J, Taylor SS. PMID: 23458248; PMCID: PMC3663052.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    131. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor SS. PMID: 23319652; PMCID: PMC3562788.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    132. Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry. 2012 Dec 21; 51(51):10186-96. Cembran A, Masterson LR, McClendon CL, Taylor SS, Gao J, Veglia G. PMID: 23205665; PMCID: PMC3545707.
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    133. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA. PMID: 23110364; PMCID: PMC3503394.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    134. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem. 2012 Dec 21; 287(52):43789-97. Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor SS, Heck AJ. PMID: 23115245; PMCID: PMC3527963.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    135. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16; 287(47):39480-91. Darshi M, Trinh KN, Murphy AN, Taylor SS. PMID: 23019327; PMCID: PMC3501047.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    136. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. Taylor SS, Ilouz R, Zhang P, Kornev AP. PMID: 22992589; PMCID: PMC3985763.
      View in: PubMed   Mentions: 230     Fields:    Translation:Cells
    137. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. Taylor SS, Keshwani MM, Steichen JM, Kornev AP. PMID: 22889904; PMCID: PMC3415842.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    138. Conformational isomers of calcineurin follow distinct dissociation pathways. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1534-43. Kükrer B, Barbu IM, Copps J, Hogan P, Taylor SS, van Duijn E, Heck AJ. PMID: 22811075; PMCID: PMC4120237.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    139. Localization and quaternary structure of the PKA RIβ holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor SS. PMID: 22797896; PMCID: PMC3411989.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    140. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. Microbes Infect. 2012 Aug; 14(10):838-50. Haste NM, Talabani H, Doo A, Merckx A, Langsley G, Taylor SS. PMID: 22626931; PMCID: PMC3967591.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    141. Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol. 2012 Sep 14; 422(2):215-29. Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y, Taylor SS. PMID: 22617327; PMCID: PMC3597442.
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    142. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. PMID: 22493239; PMCID: PMC3356610.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    143. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem. 2012 Apr 27; 287(18):14672-80. Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor SS. PMID: 22334660; PMCID: PMC3340281.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    144. Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science. 2012 Feb 10; 335(6069):712-6. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS. PMID: 22323819; PMCID: PMC3985767.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    145. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. PMID: 22318721; PMCID: PMC3339987.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    146. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. PMID: 22138346; PMCID: PMC3445030.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    147. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):E1227-35. Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. PMID: 22084075; PMCID: PMC3228425.
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    148. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor SS, Dostmann WR. PMID: 21893290; PMCID: PMC3168983.
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    149. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem. 2011 Jul 01; 286(26):23552-8. Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. PMID: 21561857; PMCID: PMC3123118.
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    150. The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One. 2011 Apr 27; 6(4):e18713. King CC, Sastri M, Chang P, Pennypacker J, Taylor SS. PMID: 21556136; PMCID: PMC3083391.
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    151. Isoform-specific targeting of PKA to multivesicular bodies. J Cell Biol. 2011 Apr 18; 193(2):347-63. Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins GA, Ellisman MH, Taylor SS. PMID: 21502359; PMCID: PMC3080257.
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    152. Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6969-74. Masterson LR, Shi L, Metcalfe E, Gao J, Taylor SS, Veglia G. PMID: 21471451; PMCID: PMC3084134.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    153. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6067-72. Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. PMID: 21441104; PMCID: PMC3076888.
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    154. Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure. 2011 Feb 09; 19(2):265-76. Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS. PMID: 21300294; PMCID: PMC3097484.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    155. The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. Protein Eng Des Sel. 2011 Mar; 24(3):333-9. McLaughlin WA, Hou T, Taylor SS, Wang W. PMID: 21115539; PMCID: PMC3038459.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    156. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Mol Cell Proteomics. 2011 Mar; 10(3):M110.004390. Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor SS, Qingsong L, Swaminathan K, Anand GS. PMID: 21081668; PMCID: PMC3047156.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    157. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor SS. PMID: 21081504; PMCID: PMC3024787.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    158. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure. 2010 Nov 10; 18(11):1471-82. Rinaldi J, Wu J, Yang J, Ralston CY, Sankaran B, Moreno S, Taylor SS. PMID: 21070946; PMCID: PMC3435106.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    159. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011 Feb; 36(2):65-77. Taylor SS, Kornev AP. PMID: 20971646; PMCID: PMC3084033.
      View in: PubMed   Mentions: 448     Fields:    Translation:HumansAnimalsCells
    160. Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol. 2010 Nov; 6(11):821-8. Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G. PMID: 20890288; PMCID: PMC3487389.
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    161. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. PMID: 20581396; PMCID: PMC2934631.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    162. Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Sci. 2010 Jun; 19(6):1213-21. Sjoberg TJ, Kornev AP, Taylor SS. PMID: 20512974; PMCID: PMC2895245.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    163. Yet another "active" pseudokinase, Erb3. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8047-8. Taylor SS, Kornev AP. PMID: 20421461; PMCID: PMC2889589.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    164. Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. J Biol Chem. 2010 May 14; 285(20):15523-15537. McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. PMID: 20202931; PMCID: PMC2865341.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    165. Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics. 2010 Oct; 9(10):2225-37. Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. PMID: 20167947; PMCID: PMC2957725.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    166. Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure. 2010 Feb 10; 18(2):155-66. Sarma GN, Kinderman FS, Kim C, von Daake S, Chen L, Wang BC, Taylor SS. PMID: 20159461; PMCID: PMC3090270.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    167. Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering. J Biol Chem. 2009 Dec 18; 284(51):35916-25. Cheng CY, Yang J, Taylor SS, Blumenthal DK. PMID: 19837668; PMCID: PMC2791020.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    168. A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry. 2009 Dec 08; 48(48):11532-45. Khavrutskii IV, Grant B, Taylor SS, McCammon JA. PMID: 19886670; PMCID: PMC2789581.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    169. Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem. 2010 Feb 05; 285(6):3825-3832. Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor SS. PMID: 19965870; PMCID: PMC2823524.
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    170. Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta. 2010 Mar; 1804(3):440-4. Kornev AP, Taylor SS. PMID: 19879387; PMCID: PMC3435107.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    171. Comparative surface geometry of the protein kinase family. Protein Sci. 2009 Oct; 18(10):2016-26. Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor SS. PMID: 19610074; PMCID: PMC2786965.
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    172. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem. 2009 Nov 20; 284(47):32869-80. Eggers CT, Schafer JC, Goldenring JR, Taylor SS. PMID: 19797056; PMCID: PMC2781703.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    173. Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. J Mol Biol. 2009 Nov 13; 393(5):1070-82. Brown SH, Wu J, Kim C, Alberto K, Taylor SS. PMID: 19748511; PMCID: PMC3435109.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    174. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Sci. 2009 Jul; 18(7):1486-97. Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor SS. PMID: 19530248; PMCID: PMC2775216.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    175. Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One. 2009; 4(3):e4746. Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. PMID: 19270744; PMCID: PMC2650257.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    176. Pseudokinases: functional insights gleaned from structure. Structure. 2009 Jan 14; 17(1):5-7. Kornev AP, Taylor SS. PMID: 19141276; PMCID: PMC6226308.
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    177. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem. 2009 Mar 06; 284(10):6241-8. Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. PMID: 19122195; PMCID: PMC2649094.
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    178. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem. 2009 Feb 20; 284(8):4921-35. Gould CM, Kannan N, Taylor SS, Newton AC. PMID: 19091746; PMCID: PMC2643500.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    179. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14377-82. Kornev AP, Taylor SS, Ten Eyck LF. PMID: 18787129; PMCID: PMC2533684.
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    180. Congenital disease SNPs target lineage specific structural elements in protein kinases. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9011-6. Torkamani A, Kannan N, Taylor SS, Schork NJ. PMID: 18579784; PMCID: PMC2449356.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    181. Rethinking pseudokinases. Cell. 2008 Apr 18; 133(2):204-5. Kannan N, Taylor SS. PMID: 18423189; PMCID: PMC6226312.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    182. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol. 2008 Apr 11; 4(4):e1000056. Kornev AP, Taylor SS, Ten Eyck LF. PMID: 18404204; PMCID: PMC2275311.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    183. A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. J Biol Chem. 2008 Apr 25; 283(17):11743-51. Ma Y, Taylor SS. PMID: 18287098; PMCID: PMC2431083.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    184. Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):506-11. Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G. PMID: 18178622; PMCID: PMC2206566.
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    185. Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta. 2008 Jan; 1784(1):238-43. Ten Eyck LF, Taylor SS, Kornev AP. PMID: 18067871.
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    186. Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B. 2007 Nov 29; 111(47):13455-64. Valiev M, Yang J, Adams JA, Taylor SS, Weare JH. PMID: 17983217.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    187. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim Biophys Acta. 2008 Jan; 1784(1):16-26. Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. PMID: 17996741; PMCID: PMC2561045.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    188. PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science. 2007 Oct 12; 318(5848):274-9. Wu J, Brown SH, von Daake S, Taylor SS. PMID: 17932298; PMCID: PMC4036697.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    189. Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases. Biochim Biophys Acta. 2008 Jan; 1784(1):27-32. Kannan N, Neuwald AF, Taylor SS. PMID: 17977811; PMCID: PMC2259278.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    190. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24; 178(7):1265-78. Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. PMID: 17893247; PMCID: PMC2064658.
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    191. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 2007 Sep 21; 130(6):1032-43. Kim C, Cheng CY, Saldanha SA, Taylor SS. PMID: 17889648.
      View in: PubMed   Mentions: 190     Fields:    Translation:Cells
    192. R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. J Mol Biol. 2007 Nov 23; 374(2):487-99. Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS. PMID: 17942118; PMCID: PMC3419600.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    193. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chem Biol. 2007 Sep; 14(9):1031-42. Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY. PMID: 17884635.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    194. Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics. Biochemistry. 2007 Aug 14; 46(32):9283-91. Anand G, Taylor SS, Johnson DA. PMID: 17658893.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    195. Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. J Biol Chem. 2007 Jul 27; 282(30):22072-9. Humphries KM, Pennypacker JK, Taylor SS. PMID: 17548350.
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    196. Identification of a molecular target for the Yersinia protein kinase A. Mol Cell. 2007 May 25; 26(4):465-77. Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon JE. PMID: 17531806.
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    197. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol. 2007 Apr; 9(4):415-21. Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg MH. PMID: 17369818.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    198. Structural and functional diversity of the microbial kinome. PLoS Biol. 2007 Mar; 5(3):e17. Kannan N, Taylor SS, Zhai Y, Venter JC, Manning G. PMID: 17355172; PMCID: PMC1821047.
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    199. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol. 2007 Mar; 5(3):e16. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor SS, Strausberg RL, Frazier M, Venter JC. PMID: 17355171; PMCID: PMC1821046.
      View in: PubMed   Mentions: 323     Fields:    Translation:PHPublic Health
    200. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. J Biol Chem. 2007 May 18; 282(20):14952-9. Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor SS. PMID: 17242405.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    201. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1272-7. Kannan N, Haste N, Taylor SS, Neuwald AF. PMID: 17227859; PMCID: PMC1783090.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    202. Evolution of allostery in the cyclic nucleotide binding module. Genome Biol. 2007; 8(12):R264. Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter JC, Taylor SS. PMID: 18076763; PMCID: PMC2246266.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    203. cAMP activation of PKA defines an ancient signaling mechanism. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):93-8. Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G. PMID: 17182741; PMCID: PMC1765484.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    204. Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem. 2006 Dec 15; 78(24):8265-72. Saldanha SA, Kaler G, Cottam HB, Abagyan R, Taylor SS. PMID: 17165815; PMCID: PMC3435108.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    205. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17783-8. Kornev AP, Haste NM, Taylor SS, Eyck LF. PMID: 17095602; PMCID: PMC1693824.
      View in: PubMed   Mentions: 343     Fields:    Translation:HumansCells
    206. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell. 2006 Nov 03; 24(3):397-408. Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA, Taylor SS. PMID: 17081990; PMCID: PMC1855097.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    207. RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Res. 2006 Oct 15; 66(20):10179-87. Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, McCallion AS, Hodgson S, Clarke S, Mondellini P, Leyland J, Pierotti MA, Whittaker J, Taylor SS, Bongarzone I, Ponder BA. PMID: 17047083.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    208. NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit. J Biomol NMR. 2006; 36 Suppl 1:64. Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G. PMID: 17016670.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    209. Structure and dynamics of PKA signaling proteins. Eur J Cell Biol. 2006 Jul; 85(7):651-4. Kim C, Vigil D, Anand G, Taylor SS. PMID: 16647784.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    210. Protein kinase resource: an integrated environment for phosphorylation research. Proteins. 2006 Apr 01; 63(1):78-86. Niedner RH, Buzko OV, Haste NM, Taylor A, Gribskov M, Taylor SS. PMID: 16435372.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    211. Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. J Mol Biol. 2006 Mar 31; 357(3):880-9. Vigil D, Blumenthal DK, Taylor SS, Trewhella J. PMID: 16460759.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    212. Dynamic binding of PKA regulatory subunit RI alpha. Structure. 2006 Jan; 14(1):141-9. Gullingsrud J, Kim C, Taylor SS, McCammon JA. PMID: 16407073.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    213. A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Sci. 2006 Jan; 15(1):113-21. Vigil D, Lin JH, Sotriffer CA, Pennypacker JK, McCammon JA, Taylor SS. PMID: 16322564; PMCID: PMC2242374.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    214. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci. 2005 Nov; 14(11):2871-9. Wu J, Yang J, Kannan N, Xuong NH, Ten Eyck LF, Taylor SS. PMID: 16253959; PMCID: PMC2253214.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    215. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci. 2005 Dec; 14(12):2982-92. Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings PA, Taylor SS, Woods VL. PMID: 16260760; PMCID: PMC2253242.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    216. PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell. 2005 Sep 23; 122(6):823-5. Taylor SS, Haste NM, Ghosh G. PMID: 16179248.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    217. Dynamics of signaling by PKA. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):25-37. Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS. PMID: 16214430.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    218. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 2005 Sep 22; 437(7058):569-73. Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. PMID: 16177793.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    219. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol. 2005 Sep 02; 351(5):1110-22. Iyer GH, Garrod S, Woods VL, Taylor SS. PMID: 16054648.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    220. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. J Biol Chem. 2005 Oct 21; 280(42):35521-7. Vigil D, Blumenthal DK, Taylor SS, Trewhella J. PMID: 16109722.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    221. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science. 2005 Feb 04; 307(5710):690-6. Kim C, Xuong NH, Taylor SS. PMID: 15692043.
      View in: PubMed   Mentions: 160     Fields:    Translation:Cells
    222. A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):349-54. Sastri M, Barraclough DM, Carmichael PT, Taylor SS. PMID: 15630084; PMCID: PMC544310.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    223. The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):45-50. Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor SS. PMID: 15618393; PMCID: PMC544069.
      View in: PubMed   Mentions: 104     Fields:    Translation:Cells
    224. Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. J Biol Chem. 2005 Mar 11; 280(10):8800-7. Iyer GH, Moore MJ, Taylor SS. PMID: 15618230.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    225. Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. J Mol Biol. 2005 Feb 11; 346(1):191-201. Yang J, Garrod SM, Deal MS, Anand GS, Woods VL, Taylor S. PMID: 15663937.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    226. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. J Biol Chem. 2005 Jan 28; 280(4):2750-8. Humphries KM, Deal MS, Taylor SS. PMID: 15533936.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    227. Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell. 2004 Sep 10; 15(5):661-75. Nolen B, Taylor S, Ghosh G. PMID: 15350212.
      View in: PubMed   Mentions: 500     Fields:    Translation:HumansAnimalsCells
    228. Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Mol Biol. 2004 Jul 23; 340(5):1185-96. Hamuro Y, Anand GS, Kim JS, Juliano C, Stranz DD, Taylor SS, Woods VL. PMID: 15236976.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    229. RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure. 2004 Jun; 12(6):1057-65. Wu J, Brown S, Xuong NH, Taylor SS. PMID: 15274925.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    230. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. Biochemistry. 2004 Jun 01; 43(21):6620-9. Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor SS. PMID: 15157095.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    231. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 2004 May 18; 43(19):5629-36. Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J. PMID: 15134437.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    232. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. J Mol Biol. 2004 Apr 09; 337(5):1183-94. Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J. PMID: 15046986.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    233. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. J Biol Chem. 2004 Apr 30; 279(18):19084-90. Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella J. PMID: 14985329.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    234. Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol. 2004 Feb 13; 336(2):473-87. Yang J, Ten Eyck LF, Xuong NH, Taylor SS. PMID: 14757059.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    235. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 2004 Jan 13; 43(1):85-96. Akamine P, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS. PMID: 14705934.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    236. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. J Biol Chem. 2004 Feb 20; 279(8):7029-36. Zawadzki KM, Taylor SS. PMID: 14625280.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    237. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int. 2003 Nov; 64(5):1746-54. Gisler SM, Madjdpour C, Bacic D, Pribanic S, Taylor SS, Biber J, Murer H. PMID: 14531807.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    238. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13264-9. Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. PMID: 14583592; PMCID: PMC263775.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    239. Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS). Protein Sci. 2003 Sep; 12(9):1980-90. Zawadzki KM, Hamuro Y, Kim JS, Garrod S, Stranz DD, Taylor SS, Woods VL. PMID: 12930997; PMCID: PMC2323995.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    240. Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. J Mol Biol. 2003 Jul 25; 330(5):1117-29. Banky P, Roy M, Newlon MG, Morikis D, Haste NM, Taylor SS, Jennings PA. PMID: 12860132.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    241. Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics. Proteins. 2003 Jun 01; 51(4):552-61. Zawadzki KM, Pan CP, Barkley MD, Johnson D, Taylor SS. PMID: 12784214.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    242. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry. 2003 May 20; 42(19):5754-63. Burns LL, Canaves JM, Pennypacker JK, Blumenthal DK, Taylor SS. PMID: 12741833.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    243. Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). J Mol Biol. 2003 Apr 11; 327(5):1065-76. Hamuro Y, Zawadzki KM, Kim JS, Stranz DD, Taylor SS, Woods VL. PMID: 12662931.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    244. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4066-71. Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A. PMID: 12646697; PMCID: PMC153049.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    245. Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4072-7. Burns-Hamuro LL, Ma Y, Kammerer S, Reineke U, Self C, Cook C, Olson GL, Cantor CR, Braun A, Taylor SS. PMID: 12646696; PMCID: PMC153050.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    246. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol. 2003 Mar 14; 327(1):159-71. Akamine P, Wu J, Xuong NH, Ten Eyck LF, Taylor SS. PMID: 12614615.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    247. Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. Proteins. 2003 Feb 01; 50(2):371-4. Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, Lesley SA, McMullan D, McPhillips TM, Miller MA, Miller MD, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Taylor SS, Hodgson KO, Wooley J, Wilson IA. PMID: 12486729.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    248. Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. J Biol Chem. 2003 Mar 21; 278(12):10613-8. Moore MJ, Adams JA, Taylor SS. PMID: 12499371.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    249. Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol. 2002 Oct 18; 323(2):377-86. Anand GS, Hughes CA, Jones JM, Taylor SS, Komives EA. PMID: 12381327.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    250. Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem. 2002 Dec 06; 277(49):47878-84. Moore MJ, Kanter JR, Jones KC, Taylor SS. PMID: 12372837.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    251. Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins. 2002 Oct 01; 49(1):142-5. Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, Jaroszewski L, Karlak C, Klock HE, Koesema E, Kovarik JM, Kreusch AT, McMullan D, McPhillips TM, Miller MA, Miller M, Morse A, Moy K, Ouyang J, Robb A, Rodrigues K, Selby TL, Spraggon G, Stevens RC, Taylor SS, van den Bedem H, Velasquez J, Vincent J, Wang X, West B, Wolf G, Wooley J, Wilson IA. PMID: 12211025.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    252. Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J Mol Biol. 2002 Aug 23; 321(4):703-14. Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V. PMID: 12206784.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    253. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11664-9. Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. PMID: 12193646; PMCID: PMC129326.
      View in: PubMed   Mentions: 150     Fields:    Translation:Cells
    254. Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem. 2002 Nov 08; 277(45):43505-11. Humphries KM, Juliano C, Taylor SS. PMID: 12189155.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    255. A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. J Biol Chem. 2002 Jul 26; 277(30):27328-36. Ma Y, Taylor S. PMID: 11994283.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    256. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol. 2002 Apr; 9(4):273-7. Akamine P, Xuong NH, Taylor SS. PMID: 11896404.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    257. Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase. J Mol Biol. 2002 Jan 18; 315(3):459-69. Li F, Gangal M, Juliano C, Gorfain E, Taylor SS, Johnson DA. PMID: 11786025.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    258. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol. 2002 Jan; 54(1):17-29. Canaves JM, Taylor SS. PMID: 11734894.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    259. Protein kinase inhibition: natural and synthetic variations on a theme. Curr Opin Chem Biol. 1997 Aug; 1(2):219-26. Taylor SS, Radzio-Andzelm E. PMID: 9667861.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
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