Susan Taylor

InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0654
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    San Diego Center for Systems Biology: From Maps to Models
    NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
    Role: Co-Investigator
    NIH/NIDDK R13DK057994Mar 20, 2000 - Feb 28, 2001
    Role: Principal Investigator
    PKA & PKC Targeting Mechanisms (Program Project)
    NIH/NIDDK P01DK054441Dec 15, 1998 - Mar 31, 2018
    Role: Principal Investigator
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    NIH/NIGMS T32GM008326Jul 1, 1989 - Jun 30, 2021
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    NIH/NIGMS R13GM036850Jun 23, 1986 - May 31, 1987
    Role: Principal Investigator
    Assembly and regulation of dynamic PKA macromolecular signaling systems
    NIH/NIGMS R01GM034921Sep 25, 1985 - May 31, 2018
    Role: Principal Investigator
    Protein Kinase - Primary Structure and cAMP Interaction
    NIH/NIGMS R01GM019301May 1, 1978 - Nov 30, 2014
    Role: Principal Investigator
    NIH/NIGMS R37GM019301May 1, 1978 - Apr 30, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. England JP, Hao Y, Bai L, Glick V, Hodges HC, Taylor S, Maillard RA. Switching of the folding-energy landscape governs the allosteric activation of protein kinase A. Proc Natl Acad Sci U S A. 2018 Jul 23. PMID: 30038016.
      View in: PubMed
    2. Meng Y, Ahuja LG, Kornev AP, Taylor S, Roux B. A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. J Mol Biol. 2018 Mar 16; 430(6):881-889. PMID: 29410316.
      View in: PubMed
    3. Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor S. Phosphorylation of protein kinase A (PKA) regulatory subunit RIa by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem. 2018 Mar 23; 293(12):4411-4421. PMID: 29378851.
      View in: PubMed
    4. Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor S, Veglia G, Simon SM. Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma. Sci Rep. 2018 Jan 15; 8(1):720. PMID: 29335433.
      View in: PubMed
    5. Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor S, Yang Y, Collins MT, Gutkind JS. Expression of an active Gas mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance. Proc Natl Acad Sci U S A. 2018 Jan 16; 115(3):E428-E437. PMID: 29282319.
      View in: PubMed
    6. Bubis J, Martínez JC, Calabokis M, Ferreira J, Sanz-Rodríguez CE, Navas V, Escalona JL, Guo Y, Taylor S. The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides. Biochimie. 2018 Mar; 146:166-180. PMID: 29288679.
      View in: PubMed
    7. Hao Y, Canavan C, Taylor S, Maillard RA. Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Sci Rep. 2017 Sep 07; 7(1):10843. PMID: 28883488.
      View in: PubMed
    8. Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor S, Perkins GA. Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. J Cell Sci. 2017 Oct 01; 130(19):3248-3260. PMID: 28808085.
      View in: PubMed
    9. Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor S, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017 Apr; 3(4):e1600663. PMID: 28435869.
      View in: PubMed
    10. P Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor S, Amaro RE. Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIa. Biochemistry. 2017 03 14; 56(10):1536-1545. PMID: 28221775.
      View in: PubMed
    11. Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor S. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):E931-E940. PMID: 28115705.
      View in: PubMed
    12. Ilouz R, Lev-Ram V, Bushong EA, Stiles TL, Friedmann-Morvinski D, Douglas C, Goldberg JL, Ellisman MH, Taylor S. Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife. 2017 01 12; 6. PMID: 28079521.
      View in: PubMed
    13. Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor S. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol. 2016 Nov; 14(11):e2000127. PMID: 27902690.
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    14. Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor S. Structure of a PKA RIa Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J Mol Biol. 2016 12 04; 428(24 Pt B):4890-4904. PMID: 27825928.
      View in: PubMed
    15. Taylor S, Minor K, Shmon CL, Shelton GD, Patterson EE, Mickelson JR. Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. J Am Anim Hosp Assoc. 2016 Nov/Dec; 52(6):364-370. PMID: 27685362.
      View in: PubMed
    16. Taylor S, Shmon C, Su L, Epp T, Minor K, Mickelson J, Patterson E, Shelton GD. Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols. J Am Anim Hosp Assoc. 2016 Sep-Oct; 52(5):281-90. PMID: 27487345.
      View in: PubMed
    17. Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor S, Stefan E. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7786-91. PMID: 27357676; PMCID: PMC4948347.
    18. Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor S, Heck AJ, Scholten A. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. FEBS J. 2016 06; 283(11):2132-48. PMID: 27028580; PMCID: PMC4980077 [Available on 06/01/17].
    19. Kim J, Li G, Walters MA, Taylor S, Veglia G. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure. 2016 Mar 01; 24(3):353-63. PMID: 26833386; PMCID: PMC4775281 [Available on 03/01/17].
    20. Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor S, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem. 2016 Mar 18; 291(12):6182-99. PMID: 26797121; PMCID: PMC4813559 [Available on 03/18/17].
    21. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor S, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. PMID: 26748707; PMCID: PMC4831919.
    22. Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor S, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIa. PLoS Biol. 2015; 13(11):e1002305. PMID: 26618408; PMCID: PMC4664472.
    23. Kornev AP, Taylor S. Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci. 2015 Nov; 40(11):628-647. PMID: 26481499.
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    24. Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor S. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12681-6. PMID: 26417071; PMCID: PMC4611605.
    25. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor S. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 01; 23(9):1563-1572. PMID: 26278174.
      View in: PubMed
    26. Antal CE, Callender JA, Kornev AP, Taylor S, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C ßII. Cell Rep. 2015 Aug 25; 12(8):1252-60. PMID: 26279568; PMCID: PMC4551583.
    27. Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor S, Herberg FW. Divalent Metal Ions Mg²? and Ca²? Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol. 2015 Oct 16; 10(10):2303-15. PMID: 26200257; PMCID: PMC4714867 [Available on 10/16/16].
    28. Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor S, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. J Biol Chem. 2015 Sep 04; 290(36):22274-86. PMID: 26203188; PMCID: PMC4571978.
    29. Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor S. Single Turnover Autophosphorylation Cycle of the PKA RIIß Holoenzyme. PLoS Biol. 2015 Jul; 13(7):e1002192. PMID: 26158466; PMCID: PMC4497662.
    30. Malmstrom RD, Kornev AP, Taylor S, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun. 2015 Jul 06; 6:7588. PMID: 26145448.
      View in: PubMed
    31. Li GC, Srivastava AK, Kim J, Taylor S, Veglia G. Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry. 2015 Jul 07; 54(26):4042-9. PMID: 26030372; PMCID: PMC4498444.
    32. Zhang P, Kornev AP, Wu J, Taylor S. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01; 7(2):227-238. PMID: 26097522.
      View in: PubMed
    33. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor S, Molinolo AA, Gutkind JS. Inactivation of a Ga(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. PMID: 25961504.
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    34. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor S, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol. 2015 May; 17(5):678-88. PMID: 25893917; PMCID: PMC4452027.
    35. Taylor S, Shaw AS, Kannan N, Kornev AP. Integration of signaling in the kinome: Architecture and regulation of the aC Helix. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1567-74. PMID: 25891902; PMCID: PMC4577442 [Available on 10/01/16].
    36. Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor S, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1575-85. PMID: 25847873; PMCID: PMC4577300 [Available on 10/01/16].
    37. Kim J, Masterson LR, Cembran A, Verardi R, Shi L, Gao J, Taylor S, Veglia G. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3716-21. PMID: 25775607; PMCID: PMC4378435.
    38. McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor S, Kochut K, Kannan N. ProKinO: a unified resource for mining the cancer kinome. Hum Mutat. 2015 Feb; 36(2):175-86. PMID: 25382819; PMCID: PMC4342772.
    39. Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA, Taylor S. D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Sci. 2015 Jan; 24(1):105-16. PMID: 25348485; PMCID: PMC4282416.
    40. Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL, Taylor S, Veglia G. Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure. 2014 Dec 02; 22(12):1735-1743. PMID: 25458836.
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    41. Niyitegeka JM, Bastidas AC, Newman RH, Taylor S, Ongeri EM. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. Am J Physiol Renal Physiol. 2015 Jan 01; 308(1):F56-68. PMID: 25354939; PMCID: PMC4281694.
    42. Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor S, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol. 2015 Jan; 35(1):264-76. PMID: 25348715; PMCID: PMC4295384.
    43. McClendon CL, Kornev AP, Gilson MK, Taylor S. Dynamic architecture of a protein kinase. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4623-31. PMID: 25319261; PMCID: PMC4217441.
    44. Boras BW, Kornev A, Taylor S, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIa activation in response to cAMP binding. J Biol Chem. 2014 Oct 24; 289(43):30040-51. PMID: 25202018; PMCID: PMC4208011.
    45. Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor S. The roles of the RIIß linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIß protein kinase A: a small angle x-ray and neutron scattering study. J Biol Chem. 2014 Oct 10; 289(41):28505-12. PMID: 25112875; PMCID: PMC4192500.
    46. Bastidas AC, Wu J, Taylor S. Molecular features of product release for the PKA catalytic cycle. Biochemistry. 2015 Jan 13; 54(1):2-10. PMID: 25077557; PMCID: PMC4295794.
    47. Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, Park SK, Rehling P, Reichert AS, Sheikh MS, Taylor S, Tsuchida N, van der Bliek AM, van der Klei IJ, Weissman JS, Westermann B, Zha J, Neupert W, Nunnari J. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol. 2014 Mar 31; 204(7):1083-6. PMID: 24687277; PMCID: PMC3971754.
    48. Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor S. Kinases and pseudokinases: lessons from RAF. Mol Cell Biol. 2014 May; 34(9):1538-46. PMID: 24567368; PMCID: PMC3993607.
    49. Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor S, Melacini G. Allosteric linkers in cAMP signalling. Biochem Soc Trans. 2014 Feb; 42(1):139-44. PMID: 24450641.
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    50. Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor S. PKA RIa homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure. 2014 Jan 07; 22(1):59-69. PMID: 24316401; PMCID: PMC3963464.
    51. Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor S, Kornev AP. Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol. 2013 Oct; 11(10):e1001680. PMID: 24143133; PMCID: PMC3797032.
    52. Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, Israeli-Rosenberg S, Manso AM, Liu Z, Milner DJ, Kaufman SJ, Patel HH, Roth DM, Hammond HK, Taylor S, Dillmann WH, Goldhaber JI, Ross RS. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013 Oct; 123(10):4294-308. PMID: 24091324; PMCID: PMC3784521.
    53. Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor S. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Mol Cell Proteomics. 2013 Dec; 12(12):3744-58. PMID: 24030101; PMCID: PMC3861721.
    54. Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor S. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. ACS Chem Biol. 2013 Oct 18; 8(10):2164-72. PMID: 23978166; PMCID: PMC3827627.
    55. Bastidas AC, Pierce LC, Walker RC, Johnson DA, Taylor S. Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry. 2013 Sep 17; 52(37):6368-79. PMID: 24003983; PMCID: PMC3788587.
    56. Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor S, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 2013 Aug 29; 154(5):1036-1046. PMID: 23993095.
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    57. Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor S, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14231-6. PMID: 23946424; PMCID: PMC3761587.
    58. Taylor S, Shaw A, Hu J, Meharena HS, Kornev A. Pseudokinases from a structural perspective. Biochem Soc Trans. 2013 Aug; 41(4):981-6. PMID: 23863167; PMCID: PMC4399968.
    59. Laanemets K, Brandt B, Li J, Merilo E, Wang YF, Keshwani MM, Taylor S, Kollist H, Schroeder JI. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol. 2013 Oct; 163(2):504-13. PMID: 23766366; PMCID: PMC3793032.
    60. Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor S, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013 Jun 01; 27(11):1223-32. PMID: 23752589; PMCID: PMC3690396.
    61. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The fractalkine/CX3CR1 system regulates ß cell function and insulin secretion. Cell. 2013 Apr 11; 153(2):413-25. PMID: 23582329; PMCID: PMC3717389.
    62. Taylor S, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PKA: lessons learned after twenty years. Biochim Biophys Acta. 2013 Jul; 1834(7):1271-8. PMID: 23535202; PMCID: PMC3763834.
    63. Bastidas AC, Deal MS, Steichen JM, Guo Y, Wu J, Taylor S. Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc. 2013 Mar 27; 135(12):4788-98. PMID: 23458248; PMCID: PMC3663052.
    64. Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, Blumenthal DK, Ali SS, Roth DM, Patel HH, Taylor S. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E387-96. PMID: 23319652; PMCID: PMC3562788.
    65. Cembran A, Masterson LR, McClendon CL, Taylor S, Gao J, Veglia G. Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry. 2012 Dec 21; 51(51):10186-96. PMID: 23205665; PMCID: PMC3545707.
    66. Guo Y, Wilderman A, Zhang L, Taylor S, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 2012 Nov 20; 51(46):9323-32. PMID: 23110364; PMCID: PMC3503394.
    67. Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor S, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem. 2012 Dec 21; 287(52):43789-97. PMID: 23115245; PMCID: PMC3527963.
    68. Darshi M, Trinh KN, Murphy AN, Taylor S. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem. 2012 Nov 16; 287(47):39480-91. PMID: 23019327; PMCID: PMC3501047.
    69. Taylor S, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol. 2012 Oct; 13(10):646-58. PMID: 22992589; PMCID: PMC3985763.
    70. Taylor S, Keshwani MM, Steichen JM, Kornev AP. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2517-28. PMID: 22889904; PMCID: PMC3415842.
    71. Kükrer B, Barbu IM, Copps J, Hogan P, Taylor S, van Duijn E, Heck AJ. Conformational isomers of calcineurin follow distinct dissociation pathways. J Am Soc Mass Spectrom. 2012 Sep; 23(9):1534-43. PMID: 22811075; PMCID: PMC4120237.
    72. Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor S. Localization and quaternary structure of the PKA RIß holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12443-8. PMID: 22797896; PMCID: PMC3411989.
    73. Haste NM, Talabani H, Doo A, Merckx A, Langsley G, Taylor S. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. Microbes Infect. 2012 Aug; 14(10):838-50. PMID: 22626931.
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    74. Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y, Taylor S. Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. J Mol Biol. 2012 Sep 14; 422(2):215-29. PMID: 22617327; PMCID: PMC3597442.
    75. Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor S. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1221-9. PMID: 22493239; PMCID: PMC3356610.
    76. Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor S. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem. 2012 Apr 27; 287(18):14672-80. PMID: 22334660; PMCID: PMC3340281.
    77. Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor S. Structure and allostery of the PKA RIIß tetrameric holoenzyme. Science. 2012 Feb 10; 335(6069):712-6. PMID: 22323819; PMCID: PMC3985767.
    78. Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor S, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. J Biol Chem. 2012 Apr 13; 287(16):13262-78. PMID: 22318721; PMCID: PMC3339987.
    79. Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor S. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol. 2012 Jan 27; 415(4):666-79. PMID: 22138346; PMCID: PMC3445030.
    80. Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor S, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):E1227-35. PMID: 22084075; PMCID: PMC3228425.
    81. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor S, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. PMID: 21893290; PMCID: PMC3168983.
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    85. Masterson LR, Shi L, Metcalfe E, Gao J, Taylor S, Veglia G. Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6969-74. PMID: 21471451; PMCID: PMC3084134.
    86. Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor S, Shaw AS. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6067-72. PMID: 21441104; PMCID: PMC3076888.
    87. Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor S. Realizing the allosteric potential of the tetrameric protein kinase A RIa holoenzyme. Structure. 2011 Feb 09; 19(2):265-76. PMID: 21300294; PMCID: PMC3097484.
    88. McLaughlin WA, Hou T, Taylor S, Wang W. The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. Protein Eng Des Sel. 2011 Mar; 24(3):333-9. PMID: 21115539; PMCID: PMC3038459.
    89. Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor S, Qingsong L, Swaminathan K, Anand GS. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Mol Cell Proteomics. 2011 Mar; 10(3):M110.004390. PMID: 21081668; PMCID: PMC3047156.
    90. Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor S. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan 28; 286(4):2918-32. PMID: 21081504; PMCID: PMC3024787.
    91. Rinaldi J, Wu J, Yang J, Ralston CY, Sankaran B, Moreno S, Taylor S. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure. 2010 Nov 10; 18(11):1471-82. PMID: 21070946; PMCID: PMC3435106.
    92. Taylor S, Kornev AP. Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci. 2011 Feb; 36(2):65-77. PMID: 20971646; PMCID: PMC3084033.
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    94. Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor S, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem. 2010 Sep 03; 285(36):27632-40. PMID: 20581396; PMCID: PMC2934631.
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    101. Khavrutskii IV, Grant B, Taylor S, McCammon JA. A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry. 2009 Dec 08; 48(48):11532-45. PMID: 19886670; PMCID: PMC2789581.
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    105. Eggers CT, Schafer JC, Goldenring JR, Taylor S. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem. 2009 Nov 20; 284(47):32869-80. PMID: 19797056; PMCID: PMC2781703.
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    113. Torkamani A, Kannan N, Taylor S, Schork NJ. Congenital disease SNPs target lineage specific structural elements in protein kinases. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9011-6. PMID: 18579784; PMCID: PMC2449356.
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    123. Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor S, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24; 178(7):1265-78. PMID: 17893247; PMCID: PMC2064658.
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    182. Anand GS, Hughes CA, Jones JM, Taylor S, Komives EA. Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol. 2002 Oct 18; 323(2):377-86. PMID: 12381327.
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    185. Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V. Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J Mol Biol. 2002 Aug 23; 321(4):703-14. PMID: 12206784.
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    189. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol. 2002 Apr; 9(4):273-7. PMID: 11896404.
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    191. Canaves JM, Taylor S. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol. 2002 Jan; 54(1):17-29. PMID: 11734894.
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    192. Taylor S, Radzio-Andzelm E. Protein kinase inhibition: natural and synthetic variations on a theme. Curr Opin Chem Biol. 1997 Aug; 1(2):219-26. PMID: 9667861.
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