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    Quyen Nguyen

    TitleTeacher
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0647
    CA La Jolla 92093
    Phone858-657-8590
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Nguyen is an associate professor in the Department of Surgery at UCSD and is a staff investigator of the Moores Cancer Center. She received her combined M.D./Ph.D. degree from Washington University, School of Medicine in St. Louis, MO. Her PhD focus, while in the lab of Jeff Lichtman, MD/PhD, was on synaptic maintenance and nerve regeneration. She developed an in-vivo fluorescence time-lapse imaging system to visualize motor nerve regeneration using transgenic mice expressing neuron-specific GFP-variant following transection injury. She showed that Schwann cell pathways persist following axonal degeneration to guide the regenerating neurites back to their original target muscle fibers. This pioneering work, published in Nature Neuroscience, served to stimulate her current clinical focus on patients with facial nerve disorders requiring nerve substitution surgery and regeneration.

      Following receiving combined MD/PhD degrees, Dr. Nguyen completed her General Surgery Internship at Barnes Jewish Hospital in St. Louis and residency subspecialty fellowship training at UCSD. She is board certified in both Head and Neck Surgery and Neurotology/Skull Base Surgery. Her clinical practice is at UCSD Health Systems where she treats and operates on patients with diseases of the ear and skull base, including cochlear implant and implantable hearing devices, management of facial nerve disorders, Meniere’s disease and tumors of the skull base. She has special interest in the facial nerve disorders and serves as Director of the Facial Nerve Clinic at UCSD, which provides evaluation and surgical treatment for patients with varying facial nerve dysfunctions, since 2009.

      In collaboration with Dr. Roger Tsien (Nobel Prize, Chemistry 2008), she is working on the development of Live Molecular Navigation (LMN) for Fluorescent Guided Surgery (FGS) also known as “color-coded surgery”. Their collaborative work has been highlighted in by several high profile media sources including Nature Research Highlights, Nature Science BusinessXchange, Nature Cancer Reviews, The Economist, and Technology Review (MIT). Dr. Nguyen holds R01 funding from the National Institute of Health (NIBIB) and the Burroughs-Wellcome Fund. She was invited to give a TED talk in 2011 on the subject of “color-coded surgery.” To date, the website has been viewed over 1 million times.

      Watch Dr. Nguyen during a recent interview with National Institute of Biomedical Imaging and Bioengineering (NIBIB) staff:

      https://www.youtube.com/watch?v=zG9-7UiKxcQ&feature=youtu.be

      In 2014, Dr. Nguyen was chosen by President Barack Obama to receive the Presidential Early Career Award for Scientists and Engineers (PECASE, award date April 15 2014), the highest honor bestowed by the U.S. government to outstanding scientists and engineers beginning their independent careers.


      Collapse Research 
      Collapse Research Activities and Funding
      Testing Fluorescently Labeled Probes for Nerve Imaging during Surgery
      NIH/NIBIB R01EB014929Aug 8, 2012 - Jul 31, 2017
      Role: Principal Investigator
      Testing Surgery Guided by Molecular Fluorescence Imaging
      NIH/NIBIB K08EB008122Sep 20, 2007 - Jul 31, 2012
      Role: Principal Investigator

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Miampamba M, Liu J, Harootunian A, Gale AJ, Baird S, Chen SL, Nguyen Q, Tsien RY, González JE. Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620. Theranostics. 2017; 7(13):3369-3386. PMID: 28900516.
        View in: PubMed
      2. Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen Q. Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncol. 2017 Aug; 71:156-162. PMID: 28688684.
        View in: PubMed
      3. Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen Q, Tsien RY. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proc Natl Acad Sci U S A. 2016 Oct 20. PMID: 27791138.
        View in: PubMed
      4. Hussain T, Nguyen LT, Whitney M, Hasselmann J, Nguyen Q. Improved facial nerve identification during parotidectomy with fluorescently labeled peptide. Laryngoscope. 2016 Dec; 126(12):2711-2717. PMID: 27171862.
        View in: PubMed
      5. Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen Q. Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. J Surg Oncol. 2016 Feb; 113(2):138-43. PMID: 26799257; PMCID: PMC4986916 [Available on 02/01/17].
      6. Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen Q, Tsien RY, Hamilton JA. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. PLoS One. 2015; 10(10):e0139833. PMID: 26448434; PMCID: PMC4598148.
      7. Malone CD, Olson ES, Mattrey RF, Jiang T, Tsien RY, Nguyen Q. Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. PLoS One. 2015; 10(9):e0137104. PMID: 26336058; PMCID: PMC4559389.
      8. Alexander TH, Harris JP, Nguyen Q, Vorasubin N. Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL. Otol Neurotol. 2015 Sep; 36(8):1321-7. PMID: 26196209.
        View in: PubMed
      9. Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen Q. Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Head Neck. 2016 May; 38(5):715-23. PMID: 25521629; PMCID: PMC4472578.
      10. Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen Q. Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome. PLoS One. 2015; 10(3):e0119600. PMID: 25751149; PMCID: PMC4353702.
      11. Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen Q. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncol. 2015 May; 51(5):470-5. PMID: 25735654; PMCID: PMC4427339.
      12. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen Q, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. PMID: 25681274; PMCID: PMC4458508.
      13. Metildi CA, Felsen CN, Savariar EN, Nguyen Q, Kaushal S, Hoffman RM, Tsien RY, Bouvet M. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Ann Surg Oncol. 2015; 22(6):2082-7. PMID: 25319581; PMCID: PMC4400250.
      14. Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen Q. Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngol Head Neck Surg. 2014 Oct; 151(4):612-8. PMID: 25091190; PMCID: PMC4469264.
      15. Gross AM, Orosco RK, Shen JP, Egloff AM, Carter H, Hofree M, Choueiri M, Coffey CS, Lippman SM, Hayes DN, Cohen EE, Grandis JR, Nguyen Q, Ideker T. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet. 2014 Sep; 46(9):939-43. PMID: 25086664; PMCID: PMC4146706.
      16. Levin RA, Felsen CN, Yang J, Lin JY, Whitney MA, Nguyen Q, Tsien RY. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS One. 2014; 9(5):e97415. PMID: 24816650; PMCID: PMC4016317.
      17. Hussain T, Nguyen Q. Molecular imaging for cancer diagnosis and surgery. Adv Drug Deliv Rev. 2014 Feb; 66:90-100. PMID: 24064465; PMCID: PMC4464660.
      18. Nguyen Q, Tsien RY. Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nat Rev Cancer. 2013 Sep; 13(9):653-62. PMID: 23924645; PMCID: PMC4427343.
      19. Orosco RK, Tsien RY, Nguyen Q. Fluorescence imaging in surgery. IEEE Rev Biomed Eng. 2013; 6:178-87. PMID: 23335674; PMCID: PMC3762450.
      20. Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen Q. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013 Jan 15; 73(2):855-64. PMID: 23188503; PMCID: PMC3799878.
      21. Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen Q, Tsien RY. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):325-30. PMID: 23080482; PMCID: PMC3694763.
      22. Shen J, Peterson M, Mafee M, Nguyen Q. Aural polyps in Samter's triad: case report and literature review. Otol Neurotol. 2012 Jul; 33(5):774-8. PMID: 22699987.
        View in: PubMed
      23. Olson ES, Whitney MA, Friedman B, Aguilera TA, Crisp JL, Baik FM, Jiang T, Baird SM, Tsimikas S, Tsien RY, Nguyen Q. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr Biol (Camb). 2012 Jun; 4(6):595-605. PMID: 22534729; PMCID: PMC3689578.
      24. Nguyen Q, Wu AP, Mastrodimos BJ, Cueva RA. Impact of fundal extension on hearing after surgery for vestibular schwannomas. Otol Neurotol. 2012 Apr; 33(3):455-8. PMID: 22334158.
        View in: PubMed
      25. Shen J, Baik F, Mafee MF, Peterson M, Nguyen Q. Inverting papilloma of the temporal bone: case report and meta-analysis of risk factors. Otol Neurotol. 2011 Sep; 32(7):1124-33. PMID: 21817933.
        View in: PubMed
      26. Baik FM, Nguyen L, Doherty JK, Harris JP, Mafee MF, Nguyen Q. Comparative case series of exostoses and osteomas of the internal auditory canal. Ann Otol Rhinol Laryngol. 2011 Apr; 120(4):255-60. PMID: 21585156.
        View in: PubMed
      27. Wu AP, Whitney MA, Crisp JL, Friedman B, Tsien RY, Nguyen Q. Improved facial nerve identification with novel fluorescently labeled probe. Laryngoscope. 2011 Apr; 121(4):805-10. PMID: 21328585; PMCID: PMC3364140.
      28. Whitney MA, Crisp JL, Nguyen LT, Friedman B, Gross LA, Steinbach P, Tsien RY, Nguyen Q. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nat Biotechnol. 2011 Apr; 29(4):352-6. PMID: 21297616; PMCID: PMC3364105.
      29. Nguyen LT, Harris JP, Nguyen Q. Erosive external otitis: a novel distinct clinical entity of the external auditory canal in nonimmunosuppressed individuals. Otol Neurotol. 2010 Dec; 31(9):1409-11. PMID: 21113981; PMCID: PMC3364102.
      30. Nguyen LT, Harris JP, Nguyen Q. Clinical utility of electrocochleography in the diagnosis and management of Ménière's disease: AOS and ANS membership survey data. Otol Neurotol. 2010 Apr; 31(3):455-9. PMID: 20104195; PMCID: PMC3037765.
      31. Olson ES, Jiang T, Aguilera TA, Nguyen Q, Ellies LG, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4311-6. PMID: 20160077; PMCID: PMC2840175.
      32. Nguyen Q, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4317-22. PMID: 20160097; PMCID: PMC2840114.
      33. King JF, Kinney AC, Iacobellis SF, Alexander TH, Harris JP, Torre P, Doherty JK, Nguyen Q. Laterality of exostosis in surfers due to evaporative cooling effect. Otol Neurotol. 2010 Feb; 31(2):345-51. PMID: 19806064.
        View in: PubMed
      34. Nguyen LT, Baik FM, Doherty JK, Harris JP, Nguyen Q. Exostoses and osteomas of the internal auditory canal. Laryngoscope. 2010; 120 Suppl 4:S215. PMID: 21225813.
        View in: PubMed
      35. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen Q, Wong EH, Gross LA, Tsien RY. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb). 2009 Jun; 1(5-6):382-93. PMID: 20023745; PMCID: PMC2796841.
      36. Vorasubin N, Sang U H, Mafee M, Nguyen Q. Glossopharyngeal schwannomas: a 100 year review. Laryngoscope. 2009 Jan; 119(1):26-35. PMID: 19117318.
        View in: PubMed
      37. Jiang T, Olson ES, Nguyen Q, Roy M, Jennings PA, Tsien RY. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17867-72. PMID: 15601762; PMCID: PMC539314.
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