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Quyen Nguyen

Title(s)Professor, Surgery
SchoolHealth Sciences
Phone858-657-8590
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    Collapse Overview 
    Collapse Overview
    Dr. Nguyen is a Professor in the Department of Surgery at UCSD and is the Associate Director of Training and Education at the Moores Cancer Center. She received her combined M.D./Ph.D. degree from Washington University, School of Medicine in St. Louis, MO. Her PhD focus, while in the lab of Jeff Lichtman, MD/PhD, was on synaptic maintenance and nerve regeneration. She developed an in-vivo fluorescence time-lapse imaging system to visualize motor nerve regeneration using transgenic mice expressing neuron-specific GFP-variant following transection injury. She showed that Schwann cell pathways persist following axonal degeneration to guide the regenerating neurites back to their original target muscle fibers. This pioneering work, published in Nature Neuroscience, served to stimulate her current clinical focus on patients with facial nerve disorders requiring nerve substitution surgery and regeneration.

    Following receiving combined MD/PhD degrees, Dr. Nguyen completed her General Surgery Internship at Barnes Jewish Hospital in St. Louis and residency subspecialty fellowship training at UCSD. She is board certified in both Head and Neck Surgery and Neurotology/Skull Base Surgery. Her clinical practice is at UCSD Health Systems where she treats and operates on patients with diseases of the ear and skull base, including cochlear implant and implantable hearing devices, management of facial nerve disorders, Meniere’s disease and tumors of the skull base. She has special interest in the facial nerve disorders and serves as Director of the Facial Nerve Clinic at UCSD, which provides evaluation and surgical treatment for patients with varying facial nerve dysfunctions, since 2009.

    In collaboration with Dr. Roger Tsien (Nobel Prize, Chemistry 2008), she is working on the development of Live Molecular Navigation (LMN) for Fluorescent Guided Surgery (FGS) also known as “color-coded surgery”. Their collaborative work has been highlighted in by several high profile media sources including Nature Research Highlights, Nature Science BusinessXchange, Nature Cancer Reviews, The Economist, and Technology Review (MIT). Dr. Nguyen holds R01 funding from the National Institute of Health (NIBIB) and the Burroughs-Wellcome Fund. She was invited to give a TED talk in 2011 on the subject of “color-coded surgery.” To date, the website has been viewed over 1 million times.

    https://www.ted.com/talks/quyen_nguyen_color_coded_surgery

    Watch Dr. Nguyen during an interview with National Institute of Biomedical Imaging and Bioengineering (NIBIB) staff:

    https://www.youtube.com/watch?v=zG9-7UiKxcQ&feature=youtu.be

    In 2014, Dr. Nguyen was chosen by President Barack Obama to receive the Presidential Early Career Award for Scientists and Engineers (PECASE, award date April 15 2014), the highest honor bestowed by the U.S. government to outstanding scientists and engineers beginning their independent careers.

    Dr. Nguyen recently founded Alume Biosciences, INC (http://alumebiosciences.com/)
    to translate nerve-localization agents for intraoperative visualization.

    Collapse Research 
    Collapse Research Activities and Funding
    Development of Human-Selective Nerve Illumination Peptide for Surgery
    NIH/NIBIB R56EB025910Sep 20, 2018 - Jun 30, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG. Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage. PLoS One. 2018; 13(9):e0198464. PMID: 30248101.
      View in: PubMed
    2. Kurabi A, Schaerer D, Noack V, Bernhardt M, Pak K, Alexander T, Husseman J, Nguyen Q, Harris JP, Ryan AF. Active Transport of Peptides Across the Intact Human Tympanic Membrane. Sci Rep. 2018 Aug 07; 8(1):11815. PMID: 30087425.
      View in: PubMed
    3. Hingorani DV, Whitney MA, Friedman B, Kwon JK, Crisp JL, Xiong Q, Gross L, Kane CJ, Tsien RY, Nguyen QT. Nerve-targeted probes for fluorescence-guided intraoperative imaging. Theranostics. 2018; 8(15):4226-4237. PMID: 30128049.
      View in: PubMed
    4. Hussain T, Chou C, Zettner E, Torre P, Hans S, Gauer J, Markgraf M, Nguyen QT. Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices. Ann Otol Rhinol Laryngol. 2018 Oct; 127(10):703-709. PMID: 30056742.
      View in: PubMed
    5. Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today (Kidlington). 2018 Nov; 21(9):951-959. PMID: 31156331.
      View in: PubMed
    6. Orosco RK, Tapia VJ, Califano JA, Clary B, Cohen EEW, Kane C, Lippman SM, Messer K, Molinolo A, Murphy JD, Pang J, Sacco A, Tringale KR, Wallace A, Nguyen QT. Positive Surgical Margins in the 10 Most Common Solid Cancers. Sci Rep. 2018 Apr 09; 8(1):5686. PMID: 29632347.
      View in: PubMed
    7. Tringale KR, Pang J, Nguyen QT. Image-guided surgery in cancer: A strategy to reduce incidence of positive surgical margins. Wiley Interdiscip Rev Syst Biol Med. 2018 05; 10(3):e1412. PMID: 29474004.
      View in: PubMed
    8. Pang J, Tringale KR, Tapia VJ, Moss WJ, May ME, Furnish T, Barnachea L, Brumund KT, Sacco AG, Weisman RA, Nguyen QT, Harris JP, Coffey CS, Califano JA. Chronic Opioid Use Following Surgery for Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg. 2017 12 01; 143(12):1187-1194. PMID: 28445584.
      View in: PubMed
    9. Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent. Arthritis Rheumatol. 2018 01; 70(1):69-79. PMID: 29164814.
      View in: PubMed
    10. Sokoya M, Ramakrishnan VR, Frank DN, Rahkola J, Getz A, Kingdom TT, Kofonow JM, Nguyen Q, Janoff EN. Expression of immunoglobulin D is increased in chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2017 10; 119(4):317-323.e1. PMID: 28958373.
      View in: PubMed
    11. Miampamba M, Liu J, Harootunian A, Gale AJ, Baird S, Chen SL, Nguyen QT, Tsien RY, González JE. Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620. Theranostics. 2017; 7(13):3369-3386. PMID: 28900516.
      View in: PubMed
    12. Khurana A, Chapelin F, Xu H, Acevedo JR, Molinolo A, Nguyen Q, Ahrens ET. Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med. 2018 04; 79(4):1972-1980. PMID: 28748562.
      View in: PubMed
    13. Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT. Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncol. 2017 08; 71:156-162. PMID: 28688684.
      View in: PubMed
    14. Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12774-12779. PMID: 27791138.
      View in: PubMed
    15. Hussain T, Nguyen LT, Whitney M, Hasselmann J, Nguyen QT. Improved facial nerve identification during parotidectomy with fluorescently labeled peptide. Laryngoscope. 2016 12; 126(12):2711-2717. PMID: 27171862.
      View in: PubMed
    16. Orosco RK, Savariar EN, Weissbrod PA, Diaz-Perez JA, Bouvet M, Tsien RY, Nguyen QT. Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. J Surg Oncol. 2016 Feb; 113(2):138-43. PMID: 26799257.
      View in: PubMed
    17. Rosenthal EL, Warram JM, de Boer E, Basilion JP, Biel MA, Bogyo M, Bouvet M, Brigman BE, Colson YL, DeMeester SR, Gurtner GC, Ishizawa T, Jacobs PM, Keereweer S, Liao JC, Nguyen QT, Olson JM, Paulsen KD, Rieves D, Sumer BD, Tweedle MF, Vahrmeijer AL, Weichert JP, Wilson BC, Zenn MR, Zinn KR, van Dam GM. Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report. J Nucl Med. 2016 Jan; 57(1):144-50. PMID: 26449839.
      View in: PubMed
    18. Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. PLoS One. 2015; 10(10):e0139833. PMID: 26448434.
      View in: PubMed
    19. Malone CD, Olson ES, Mattrey RF, Jiang T, Tsien RY, Nguyen QT. Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. PLoS One. 2015; 10(9):e0137104. PMID: 26336058; PMCID: PMC4559389.
    20. Alexander TH, Harris JP, Nguyen QT, Vorasubin N. Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL. Otol Neurotol. 2015 Sep; 36(8):1321-7. PMID: 26196209.
      View in: PubMed
    21. Hussain T, Savariar EN, Diaz-Perez JA, Messer K, Pu M, Tsien RY, Nguyen QT. Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Head Neck. 2016 May; 38(5):715-23. PMID: 25521629; PMCID: PMC4472578.
    22. Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT. Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome. PLoS One. 2015; 10(3):e0119600. PMID: 25751149; PMCID: PMC4353702.
    23. Raju SC, Hauff SJ, Lemieux AJ, Orosco RK, Gross AM, Nguyen LT, Savariar E, Moss W, Whitney M, Cohen EE, Lippman SM, Tsien RY, Ideker T, Advani SJ, Nguyen QT. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncol. 2015 May; 51(5):470-5. PMID: 25735654; PMCID: PMC4427339.
    24. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. PMID: 25681274; PMCID: PMC4458508.
    25. Metildi CA, Felsen CN, Savariar EN, Nguyen QT, Kaushal S, Hoffman RM, Tsien RY, Bouvet M. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Ann Surg Oncol. 2015; 22(6):2082-7. PMID: 25319581; PMCID: PMC4400250.
    26. Hauff SJ, Raju SC, Orosco RK, Gross AM, Diaz-Perez JA, Savariar E, Nashi N, Hasselman J, Whitney M, Myers JN, Lippman SM, Tsien RY, Ideker T, Nguyen QT. Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngol Head Neck Surg. 2014 Oct; 151(4):612-8. PMID: 25091190.
      View in: PubMed
    27. Gross AM, Orosco RK, Shen JP, Egloff AM, Carter H, Hofree M, Choueiri M, Coffey CS, Lippman SM, Hayes DN, Cohen EE, Grandis JR, Nguyen QT, Ideker T. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet. 2014 Sep; 46(9):939-43. PMID: 25086664; PMCID: PMC4146706.
    28. Levin RA, Felsen CN, Yang J, Lin JY, Whitney MA, Nguyen QT, Tsien RY. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS One. 2014; 9(5):e97415. PMID: 24816650; PMCID: PMC4016317.
    29. Hussain T, Nguyen QT. Molecular imaging for cancer diagnosis and surgery. Adv Drug Deliv Rev. 2014 Feb; 66:90-100. PMID: 24064465; PMCID: PMC4464660.
    30. Nguyen QT, Tsien RY. Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nat Rev Cancer. 2013 Sep; 13(9):653-62. PMID: 23924645; PMCID: PMC4427343.
    31. Orosco RK, Tsien RY, Nguyen QT. Fluorescence imaging in surgery. IEEE Rev Biomed Eng. 2013; 6:178-87. PMID: 23335674; PMCID: PMC3762450.
    32. Savariar EN, Felsen CN, Nashi N, Jiang T, Ellies LG, Steinbach P, Tsien RY, Nguyen QT. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013 Jan 15; 73(2):855-64. PMID: 23188503; PMCID: PMC3799878.
    33. Whitney M, Savariar EN, Friedman B, Levin RA, Crisp JL, Glasgow HL, Lefkowitz R, Adams SR, Steinbach P, Nashi N, Nguyen QT, Tsien RY. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):325-30. PMID: 23080482; PMCID: PMC3694763.
    34. Shen J, Peterson M, Mafee M, Nguyen QT. Aural polyps in Samter's triad: case report and literature review. Otol Neurotol. 2012 Jul; 33(5):774-8. PMID: 22699987.
      View in: PubMed
    35. Olson ES, Whitney MA, Friedman B, Aguilera TA, Crisp JL, Baik FM, Jiang T, Baird SM, Tsimikas S, Tsien RY, Nguyen QT. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr Biol (Camb). 2012 Jun; 4(6):595-605. PMID: 22534729; PMCID: PMC3689578.
    36. Nguyen QT, Wu AP, Mastrodimos BJ, Cueva RA. Impact of fundal extension on hearing after surgery for vestibular schwannomas. Otol Neurotol. 2012 Apr; 33(3):455-8. PMID: 22334158.
      View in: PubMed
    37. Shen J, Baik F, Mafee MF, Peterson M, Nguyen QT. Inverting papilloma of the temporal bone: case report and meta-analysis of risk factors. Otol Neurotol. 2011 Sep; 32(7):1124-33. PMID: 21817933.
      View in: PubMed
    38. Baik FM, Nguyen L, Doherty JK, Harris JP, Mafee MF, Nguyen QT. Comparative case series of exostoses and osteomas of the internal auditory canal. Ann Otol Rhinol Laryngol. 2011 Apr; 120(4):255-60. PMID: 21585156.
      View in: PubMed
    39. Wu AP, Whitney MA, Crisp JL, Friedman B, Tsien RY, Nguyen QT. Improved facial nerve identification with novel fluorescently labeled probe. Laryngoscope. 2011 Apr; 121(4):805-10. PMID: 21328585; PMCID: PMC3364140.
    40. Whitney MA, Crisp JL, Nguyen LT, Friedman B, Gross LA, Steinbach P, Tsien RY, Nguyen QT. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nat Biotechnol. 2011 Apr; 29(4):352-6. PMID: 21297616; PMCID: PMC3364105.
    41. Nguyen LT, Harris JP, Nguyen QT. Erosive external otitis: a novel distinct clinical entity of the external auditory canal in nonimmunosuppressed individuals. Otol Neurotol. 2010 Dec; 31(9):1409-11. PMID: 21113981; PMCID: PMC3364102.
    42. Harris JP, Nguyen QT. Meniere's disease: 150 years and still elusive. Otolaryngol Clin North Am. 2010 Oct; 43(5):xiii-xiv. PMID: 20713235.
      View in: PubMed
    43. Nguyen LT, Harris JP, Nguyen QT. Clinical utility of electrocochleography in the diagnosis and management of Ménière's disease: AOS and ANS membership survey data. Otol Neurotol. 2010 Apr; 31(3):455-9. PMID: 20104195; PMCID: PMC3037765.
    44. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4311-6. PMID: 20160077; PMCID: PMC2840175.
    45. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4317-22. PMID: 20160097; PMCID: PMC2840114.
    46. King JF, Kinney AC, Iacobellis SF, Alexander TH, Harris JP, Torre P, Doherty JK, Nguyen QT. Laterality of exostosis in surfers due to evaporative cooling effect. Otol Neurotol. 2010 Feb; 31(2):345-51. PMID: 19806064.
      View in: PubMed
    47. Nguyen LT, Baik FM, Doherty JK, Harris JP, Nguyen QT. Exostoses and osteomas of the internal auditory canal. Laryngoscope. 2010; 120 Suppl 4:S215. PMID: 21225813.
      View in: PubMed
    48. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb). 2009 Jun; 1(5-6):382-93. PMID: 20023745; PMCID: PMC2796841.
    49. Vorasubin N, Sang U H, Mafee M, Nguyen QT. Glossopharyngeal schwannomas: a 100 year review. Laryngoscope. 2009 Jan; 119(1):26-35. PMID: 19117318.
      View in: PubMed
    50. Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17867-72. PMID: 15601762; PMCID: PMC539314.
    51. Nguyen QT, Sanes JR, Lichtman JW. Pre-existing pathways promote precise projection patterns. Nat Neurosci. 2002 Sep; 5(9):861-7. PMID: 12172551.
      View in: PubMed