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Quyen Nguyen

Title(s)Professor, Surgery
SchoolHealth Sciences
Address9500 Gilman Drive #0647
La Jolla CA 92093
Phone858-657-8590
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    Dr. Nguyen is a Professor in the Department of Surgery at UCSD and is the Associate Director of Training and Education at the Moores Cancer Center. She received her combined M.D./Ph.D. degree from Washington University, School of Medicine in St. Louis, MO. Her PhD focus, while in the lab of Jeff Lichtman, MD/PhD, was on synaptic maintenance and nerve regeneration. She developed an in-vivo fluorescence time-lapse imaging system to visualize motor nerve regeneration using transgenic mice expressing neuron-specific GFP-variant following transection injury. She showed that Schwann cell pathways persist following axonal degeneration to guide the regenerating neurites back to their original target muscle fibers. This pioneering work, published in Nature Neuroscience, served to stimulate her current clinical focus on patients with facial nerve disorders requiring nerve substitution surgery and regeneration.

    Following receiving combined MD/PhD degrees, Dr. Nguyen completed her General Surgery Internship at Barnes Jewish Hospital in St. Louis and residency subspecialty fellowship training at UCSD. She is board certified in both Head and Neck Surgery and Neurotology/Skull Base Surgery. Her clinical practice is at UCSD Health Systems where she treats and operates on patients with diseases of the ear and skull base, including cochlear implant and implantable hearing devices, management of facial nerve disorders, Meniere’s disease and tumors of the skull base. She has special interest in the facial nerve disorders and serves as Director of the Facial Nerve Clinic at UCSD, which provides evaluation and surgical treatment for patients with varying facial nerve dysfunctions, since 2009.

    In collaboration with Dr. Roger Tsien (Nobel Prize, Chemistry 2008), she is working on the development of Live Molecular Navigation (LMN) for Fluorescent Guided Surgery (FGS) also known as “color-coded surgery”. Their collaborative work has been highlighted in by several high profile media sources including Nature Research Highlights, Nature Science BusinessXchange, Nature Cancer Reviews, The Economist, and Technology Review (MIT). Dr. Nguyen holds R01 funding from the National Institute of Health (NIBIB) and the Burroughs-Wellcome Fund. She was invited to give a TED talk in 2011 on the subject of “color-coded surgery.” To date, the website has been viewed over 1 million times.

    https://www.ted.com/talks/quyen_nguyen_color_coded_surgery

    Watch Dr. Nguyen during an interview with National Institute of Biomedical Imaging and Bioengineering (NIBIB) staff:

    https://www.youtube.com/watch?v=zG9-7UiKxcQ&feature=youtu.be

    In 2014, Dr. Nguyen was chosen by President Barack Obama to receive the Presidential Early Career Award for Scientists and Engineers (PECASE, award date April 15 2014), the highest honor bestowed by the U.S. government to outstanding scientists and engineers beginning their independent careers.

    Dr. Nguyen recently founded Alume Biosciences, INC (http://alumebiosciences.com/)
    to translate nerve-localization agents for intraoperative visualization.

    Collapse Research 
    Collapse Research Activities and Funding
    Development of Human-Selective Nerve Illumination Peptide for Surgery
    NIH R56EB025910Sep 20, 2018 - Jun 30, 2020
    Role: Principal Investigator
    Injectable reporters to image tumors and guide resection
    NIH R01CA158448Sep 16, 2011 - Jul 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Direct Costs of Microsurgical Resection of Vestibular Schwannomas. Otol Neurotol. 2020 Mar; 41(3):397-402. Saliba J, Mohammadzadeh A, Tawfik KO, Carriere JS, Schwartz MS, Nguyen QT, Friedman RA. PMID: 31868780.
      View in: PubMed   Mentions:    Fields:    
    2. Fluorescence Imaging of Nerves During Surgery. Ann Surg. 2019 07; 270(1):69-76. Walsh EM, Cole D, Tipirneni KE, Bland KI, Udayakumar N, Kasten BB, Bevans SL, McGrew BM, Kain JJ, Nguyen QT, Rosenthal EL, Warram JM. PMID: 30649014.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage. PLoS One. 2018; 13(9):e0198464. Hingorani DV, Lippert CN, Crisp JL, Savariar EN, Hasselmann JPC, Kuo C, Nguyen QT, Tsien RY, Whitney MA, Ellies LG. PMID: 30248101.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. Active Transport of Peptides Across the Intact Human Tympanic Membrane. Sci Rep. 2018 08 07; 8(1):11815. Kurabi A, Schaerer D, Noack V, Bernhardt M, Pak K, Alexander T, Husseman J, Nguyen Q, Harris JP, Ryan AF. PMID: 30087425.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Nerve-targeted probes for fluorescence-guided intraoperative imaging. Theranostics. 2018; 8(15):4226-4237. Hingorani DV, Whitney MA, Friedman B, Kwon JK, Crisp JL, Xiong Q, Gross L, Kane CJ, Tsien RY, Nguyen QT. PMID: 30128049.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices. Ann Otol Rhinol Laryngol. 2018 Oct; 127(10):703-709. Hussain T, Chou C, Zettner E, Torre P, Hans S, Gauer J, Markgraf M, Nguyen QT. PMID: 30056742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Rapid continuous 3D printing of customizable peripheral nerve guidance conduits. Mater Today (Kidlington). 2018 Nov; 21(9):951-959. Zhu W, Tringale KR, Woller SA, You S, Johnson S, Shen H, Schimelman J, Whitney M, Steinauer J, Xu W, Yaksh TL, Nguyen QT, Chen S. PMID: 31156331.
      View in: PubMed   Mentions:
    8. Positive Surgical Margins in the 10 Most Common Solid Cancers. Sci Rep. 2018 04 09; 8(1):5686. PMID: 29632347.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    9. Image-guided surgery in cancer: A strategy to reduce incidence of positive surgical margins. Wiley Interdiscip Rev Syst Biol Med. 2018 05; 10(3):e1412. Tringale KR, Pang J, Nguyen QT. PMID: 29474004.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    10. Chronic Opioid Use Following Surgery for Oral Cavity Cancer. JAMA Otolaryngol Head Neck Surg. 2017 12 01; 143(12):1187-1194. Pang J, Tringale KR, Tapia VJ, Moss WJ, May ME, Furnish T, Barnachea L, Brumund KT, Sacco AG, Weisman RA, Nguyen QT, Harris JP, Coffey CS, Califano JA. PMID: 28445584.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent. Arthritis Rheumatol. 2018 01; 70(1):69-79. PMID: 29164814.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Expression of immunoglobulin D is increased in chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2017 10; 119(4):317-323.e1. Sokoya M, Ramakrishnan VR, Frank DN, Rahkola J, Getz A, Kingdom TT, Kofonow JM, Nguyen Q, Janoff EN. PMID: 28958373.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620. Theranostics. 2017; 7(13):3369-3386. PMID: 28900516.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. Visualization of macrophage recruitment in head and neck carcinoma model using fluorine-19 magnetic resonance imaging. Magn Reson Med. 2018 04; 79(4):1972-1980. PMID: 28748562.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides. Oral Oncol. 2017 08; 71:156-162. Hingorani DV, Lemieux AJ, Acevedo JR, Glasgow HL, Kedarisetty S, Whitney MA, Molinolo AA, Tsien RY, Nguyen QT. PMID: 28688684.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12774-12779. PMID: 27791138.
      View in: PubMed   Mentions: 6     Fields:    
    17. Improved facial nerve identification during parotidectomy with fluorescently labeled peptide. Laryngoscope. 2016 12; 126(12):2711-2717. PMID: 27171862.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    18. Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model. J Surg Oncol. 2016 Feb; 113(2):138-43. PMID: 26799257.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    19. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. PLoS One. 2015; 10(10):e0139833. PMID: 26448434.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    20. Successful Translation of Fluorescence Navigation During Oncologic Surgery: A Consensus Report. J Nucl Med. 2016 Jan; 57(1):144-50. PMID: 26449839.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    21. Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. PLoS One. 2015; 10(9):e0137104. PMID: 26336058.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Dose Effect of Intratympanic Dexamethasone for Idiopathic Sudden Sensorineural Hearing Loss: 24 mg/mL Is Superior to 10 mg/mL. Otol Neurotol. 2015 Sep; 36(8):1321-7. PMID: 26196209.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers. Head Neck. 2016 May; 38(5):715-23. PMID: 25521629.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    24. Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome. PLoS One. 2015; 10(3):e0119600. PMID: 25751149.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    25. Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma. Oral Oncol. 2015 May; 51(5):470-5. PMID: 25735654.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. PMID: 25681274.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    27. Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Ann Surg Oncol. 2015; 22(6):2082-7. PMID: 25319581.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    28. Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngol Head Neck Surg. 2014 Oct; 151(4):612-8. PMID: 25091190.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet. 2014 Sep; 46(9):939-43. PMID: 25086664.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    30. An optimized triple modality reporter for quantitative in vivo tumor imaging and therapy evaluation. PLoS One. 2014; 9(5):e97415. PMID: 24816650.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Molecular imaging for cancer diagnosis and surgery. Adv Drug Deliv Rev. 2014 Feb; 66:90-100. PMID: 24064465.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    32. Fluorescence-guided surgery with live molecular navigation--a new cutting edge. Nat Rev Cancer. 2013 Sep; 13(9):653-62. PMID: 23924645.
      View in: PubMed   Mentions: 156     Fields:    Translation:Humans
    33. Fluorescence imaging in surgery. IEEE Rev Biomed Eng. 2013; 6:178-87. PMID: 23335674.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    34. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013 Jan 15; 73(2):855-64. PMID: 23188503.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    35. Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):325-30. PMID: 23080482.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    36. Aural polyps in Samter's triad: case report and literature review. Otol Neurotol. 2012 Jul; 33(5):774-8. PMID: 22699987.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integr Biol (Camb). 2012 Jun; 4(6):595-605. PMID: 22534729.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    38. Impact of fundal extension on hearing after surgery for vestibular schwannomas. Otol Neurotol. 2012 Apr; 33(3):455-8. PMID: 22334158.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Inverting papilloma of the temporal bone: case report and meta-analysis of risk factors. Otol Neurotol. 2011 Sep; 32(7):1124-33. PMID: 21817933.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. Comparative case series of exostoses and osteomas of the internal auditory canal. Ann Otol Rhinol Laryngol. 2011 Apr; 120(4):255-60. Baik FM, Nguyen L, Doherty JK, Harris JP, Mafee MF, Nguyen QT. PMID: 21585156.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    41. Improved facial nerve identification with novel fluorescently labeled probe. Laryngoscope. 2011 Apr; 121(4):805-10. Wu AP, Whitney MA, Crisp JL, Friedman B, Tsien RY, Nguyen QT. PMID: 21328585.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    42. Fluorescent peptides highlight peripheral nerves during surgery in mice. Nat Biotechnol. 2011 Apr; 29(4):352-6. Whitney MA, Crisp JL, Nguyen LT, Friedman B, Gross LA, Steinbach P, Tsien RY, Nguyen QT. PMID: 21297616.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    43. Erosive external otitis: a novel distinct clinical entity of the external auditory canal in nonimmunosuppressed individuals. Otol Neurotol. 2010 Dec; 31(9):1409-11. Nguyen LT, Harris JP, Nguyen QT. PMID: 21113981.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    44. Meniere's disease: 150 years and still elusive. Otolaryngol Clin North Am. 2010 Oct; 43(5):xiii-xiv. Harris JP, Nguyen QT. PMID: 20713235.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Clinical utility of electrocochleography in the diagnosis and management of Ménière's disease: AOS and ANS membership survey data. Otol Neurotol. 2010 Apr; 31(3):455-9. Nguyen LT, Harris JP, Nguyen QT. PMID: 20104195.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    46. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4311-6. Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. PMID: 20160077.
      View in: PubMed   Mentions: 171     Fields:    Translation:Animals
    47. Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4317-22. Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. PMID: 20160097.
      View in: PubMed   Mentions: 156     Fields:    Translation:Animals
    48. Laterality of exostosis in surfers due to evaporative cooling effect. Otol Neurotol. 2010 Feb; 31(2):345-51. King JF, Kinney AC, Iacobellis SF, Alexander TH, Harris JP, Torre P, Doherty JK, Nguyen QT. PMID: 19806064.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    49. Exostoses and osteomas of the internal auditory canal. Laryngoscope. 2010; 120 Suppl 4:S215. Nguyen LT, Baik FM, Doherty JK, Harris JP, Nguyen QT. PMID: 21225813.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    50. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb). 2009 Jun; 1(5-6):382-93. Olson ES, Aguilera TA, Jiang T, Ellies LG, Nguyen QT, Wong EH, Gross LA, Tsien RY. PMID: 20023745.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    51. Glossopharyngeal schwannomas: a 100 year review. Laryngoscope. 2009 Jan; 119(1):26-35. Vorasubin N, Sang U H, Mafee M, Nguyen QT. PMID: 19117318.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    52. Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17867-72. Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY. PMID: 15601762.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansAnimalsCells
    53. Pre-existing pathways promote precise projection patterns. Nat Neurosci. 2002 Sep; 5(9):861-7. Nguyen QT, Sanes JR, Lichtman JW. PMID: 12172551.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
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