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    Maike Sander

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
    Phone858-246-0843
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      Collapse Overview 
      Collapse Overview
      Our laboratory studies the molecular mechanisms that underlie the differentiation, function and regeneration of cells in the pancreas. We investigate these mechanisms in the context of normal physiology, diabetes and cancer. In our research, we combine of variety experimental systems, including mouse genetics, a human embryonic stem cell-based in vitro differentiation platform, as well as genomic and biochemical approaches.
      In recent studies, we mapped dynamic changes in the transcriptome and epigenome during the progression of pluripotent stem cells toward the pancreatic fate and discovered how chromatin remodeling events prepare developmental precursors to receive and correctly interpret organ-inductive signals. In current work, we are exploring how the cellular environment shapes the epigenome and thereby influences cellular phenotypes in the pancreas. Such knowledge will likely yield an understanding of the mechanisms underlying diseases influenced by both environmental and genetic factors, such as diabetes.

      Research Focus Areas:

    • Developmental Biology

    • Genetics and Genomics

    • Gene Expression and Regulation

    • Stem Cell Biology



    • Collapse Research 
      Collapse Research Activities and Funding
      Fine-mapping and functional analysis of T1D-associated variants
      NIH DP3DK112155Sep 30, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Functional Analysis of T2D Associated Non-coding SNPs
      NIH U01DK105541May 1, 2015 - Apr 30, 2020
      Role: Principal Investigator
      A novel mouse model to identify biomarkers of IPMN formation and progression
      NIH R21CA194839Apr 1, 2015 - Mar 31, 2017
      Role: Principal Investigator
      A 3-D biomimetic human islet to model beta cell function in health and disease
      NIH UC4DK104202Sep 20, 2014 - Jun 30, 2019
      Role: Principal Investigator
      Epigenetic strategies for the in vitro generation of replacement beta cells
      NIH U01DK089567Sep 17, 2010 - Jun 30, 2014
      Role: Principal Investigator
      Mechanisms of pancreatic endocrine cell differentiation
      NIH R01DK078803Sep 1, 2007 - Jun 30, 2017
      Role: Principal Investigator
      Mechanisms of Pancreatic Beta Cell Specification
      NIH R01DK068471Jun 1, 2004 - Jul 31, 2015
      Role: Principal Investigator
      Diabetes Research Center (DRC)
      NIH P30DK063491Dec 1, 2002 - Apr 30, 2018
      Role: Co-Investigator
      IVEM and Image Analysis Resource
      NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Shih HP, Panlasigui D, Cirulli V, Sander M. ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis. Cell Rep. 2016 Jan 12; 14(2):169-79. PMID: 26748698.
        View in: PubMed
      2. Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep. 2015 Oct 13; 13(2):326-36. PMID: 26440894.
        View in: PubMed
      3. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. PMID: 26276631.
        View in: PubMed
      4. Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, Sander M. Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates. Cell Stem Cell. 2015 Apr 2; 16(4):386-99. PMID: 25842977.
        View in: PubMed
      5. Xie R, Carrano AC, Sander M. A systems view of epigenetic networks regulating pancreas development and ß-cell function. Wiley Interdiscip Rev Syst Biol Med. 2015 Jan; 7(1):1-11. PMID: 25644779.
        View in: PubMed
      6. Zhao X, Chen Y, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M. Control of astrocyte progenitor specification, migration and maturation by nkx6.1 homeodomain transcription factor. PLoS One. 2014; 9(10):e109171. PMID: 25285789.
        View in: PubMed
      7. Taylor BL, Benthuysen J, Sander M. Postnatal ß-Cell Proliferation and Mass Expansion Is Dependent on the Transcription Factor Nkx6.1. Diabetes. 2015 Mar; 64(3):897-903. PMID: 25277396.
        View in: PubMed
      8. Shih HP, Sander M. Pancreas development ex vivo: culturing embryonic pancreas explants on permeable culture inserts, with fibronectin-coated glass microwells, or embedded in three-dimensional matrigel™. Methods Mol Biol. 2014; 1210:229-37. PMID: 25173172.
        View in: PubMed
      9. Kopp JL, Sander M. New insights into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions? Gastroenterology. 2014 Jan; 146(1):24-6. PMID: 24275238.
        View in: PubMed
      10. Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4456-64. PMID: 24191021.
        View in: PubMed
      11. Taylor BL, Liu FF, Sander M. Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep. 2013 Sep 26; 4(6):1262-75. PMID: 24035389.
        View in: PubMed
      12. Shih HP, Wang A, Sander M. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol. 2013; 29:81-105. PMID: 23909279.
        View in: PubMed
      13. Jin L, Feng T, Shih HP, Zerda R, Luo A, Hsu J, Mahdavi A, Sander M, Tirrell DA, Riggs AD, Ku HT. Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10):3907-12. PMID: 23431132.
        View in: PubMed
      14. Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013; 9(1):e1003274. PMID: 23382704.
        View in: PubMed
      15. Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 2013 Feb 7; 12(2):224-37. PMID: 23318056.
        View in: PubMed
      16. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Dec 11; 22(6):737-50. PMID: 23201164.
        View in: PubMed
      17. Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep; 139(18):3363-72. PMID: 22874919.
        View in: PubMed
      18. Wang A, Sander M. Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells. J Mol Med (Berl). 2012 Jul; 90(7):763-71. PMID: 22714642.
        View in: PubMed
      19. Shih HP, Kopp JL, Sandhu M, Dubois CL, Seymour PA, Grapin-Botton A, Sander M. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development. 2012 Jul; 139(14):2488-99. PMID: 22675211.
        View in: PubMed
      20. Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M. Transgenic overexpression of the transcription factor Nkx6.1 in ß-cells of mice does not increase ß-cell proliferation, ß-cell mass, or improve glucose clearance. Mol Endocrinol. 2011 Nov; 25(11):1904-14. PMID: 21964593.
        View in: PubMed
      21. Dubois CL, Shih HP, Seymour PA, Patel NA, Behrmann JM, Ngo V, Sander M. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One. 2011; 6(8):e23131. PMID: 21829703.
        View in: PubMed
      22. Kopp JL, Dubois CL, Hao E, Thorel F, Herrera PL, Sander M. Progenitor cell domains in the developing and adult pancreas. Cell Cycle. 2011 Jun 15; 10(12):1921-7. PMID: 21558806.
        View in: PubMed
      23. Seymour PA, Sander M. Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes. 2011 Feb; 60(2):364-76. PMID: 21270248.
        View in: PubMed
      24. Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011 Feb; 138(4):653-65. PMID: 21266405.
        View in: PubMed
      25. Schaffer AE, Freude KK, Nelson SB, Sander M. Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell. 2010 Jun 15; 18(6):1022-9. PMID: 20627083.
        View in: PubMed
      26. Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008 Nov 1; 323(1):19-30. PMID: 18723011.
        View in: PubMed
      27. Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M. Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15; 318(2):224-35. PMID: 18452912.
        View in: PubMed
      28. Nelson SB, Schaffer AE, Sander M. The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development. 2007 Jul; 134(13):2491-500. PMID: 17537793.
        View in: PubMed
      29. Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M. NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development. 2005 Jul; 132(13):3139-49. PMID: 15944193.
        View in: PubMed
      30. Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M. Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development. 2003 Dec; 130(25):6221-31. PMID: 14602683.
        View in: PubMed