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Maike Sander

Photo of Maike Sander
Title(s)Adjunct Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse awards and honors
    2020Elected Member, Association of American Physicians
    2017Elected Member, German National Academy of Sciences (Leopoldina)
    2017Humboldt Research Award
    2011Elected Member, American Society for Clinical Investigation
    2008Grodsky Award, Juvenile Diabetes Research Foundation

    Collapse Overview 
    Collapse overview
    Our laboratory studies the molecular mechanisms that underlie the differentiation, function and regeneration of cells in the pancreas. We investigate these mechanisms in the context of normal physiology, diabetes and cancer. In our research, we combine of variety experimental systems, including mouse genetics, a human embryonic stem cell-based in vitro differentiation platform, as well as genomic and biochemical approaches.
    In recent studies, we mapped dynamic changes in the transcriptome and epigenome during the progression of pluripotent stem cells toward the pancreatic fate and discovered how chromatin remodeling events prepare developmental precursors to receive and correctly interpret organ-inductive signals. In current work, we are exploring how the cellular environment shapes the epigenome and thereby influences cellular phenotypes in the pancreas. Such knowledge will likely yield an understanding of the mechanisms underlying diseases influenced by both environmental and genetic factors, such as diabetes.

    Research Focus Areas:

  • Developmental Biology

  • Genetics and Genomics

  • Gene Expression and Regulation

  • Stem Cell Biology


    • Collapse Research 
    Collapse research activities and funding
    The impact of genomic variation on environment-induced changes in pancreatic beta cell states
    NIH U01HG012059Sep 7, 2021 - May 31, 2026
    Role: Principal Investigator
    A 3D vascularized islet biomimetic to model type 1 diabetes
    NIH UG3DK122639Aug 1, 2019 - Jul 31, 2024
    Role: Principal Investigator
    A 3D vascularized islet biomimetic to model type 1 diabetes
    NIH UH3DK122639Aug 1, 2019 - Jul 31, 2024
    Role: Principal Investigator
    Genetic mechanisms of type 1 diabetes risk in stress-induced pancreatic islets
    NIH R01DK122607Aug 1, 2019 - May 31, 2023
    Role: Co-Principal Investigator
    Pancreatic Diseases Gordon Research Conference
    NIH R13DK121395Mar 1, 2019 - Feb 29, 2020
    Role: Principal Investigator
    Single cell analysis of the human pancreas in type 1 diabetes
    NIH U01DK120429Sep 25, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Promotion of beta cell proliferation by epigenetically reprogrammed macrophages
    NIH R01DK114427Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Fine-mapping and functional analysis of T1D-associated variants
    NIH DP3DK112155Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Functional Analysis of T2D Associated Non-coding SNPs
    NIH U01DK105541May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    A novel mouse model to identify biomarkers of IPMN formation and progression
    NIH R21CA194839Apr 1, 2015 - Mar 31, 2018
    Role: Principal Investigator
    A 3-D biomimetic human islet to model beta cell function in health and disease
    NIH UC4DK104202Sep 20, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Epigenetic strategies for the in vitro generation of replacement beta cells
    NIH U01DK089567Sep 17, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Novel insights into nutrient-dependent regulation of beta cell proliferation
    NIH R01DK078803Sep 1, 2007 - Jun 30, 2024
    Role: Principal Investigator
    Epigenetic determinants of beta cell development and function
    NIH R01DK068471Jun 1, 2004 - Jul 31, 2025
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH P30DK063491Dec 1, 2002 - Jun 30, 2025
    Role: Co-Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis. J Clin Invest. 2025 Nov 17; 135(22). Clausen TM, Weiss RJ, Tremblay JR, Kellman BP, Coker J, Dworkin LA, Rodriguez JP, Chang IM, Chen T, Padala V, Karlsson R, Song H, Peck KL, Ogawa S, Sandoval DR, Joshi HJ, Wang G, Ferguson LP, Bhalerao N, Moores A, Reya T, Sander M, Caffrey TC, Grem JL, Aicher A, Heeschen C, Le D, Lewis NE, Hollingsworth MA, Grandgenett PM, Bellis SL, Miller RL, Fuster MM, Dawson DW, Engle DD, Esko JD. PMID: 40924474; PMCID: PMC12618072.
      View in: PubMed   Mentions:    Fields:    
    2. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs of type 1 diabetes progression. Sci Adv. 2025 Sep 12; 11(37):eady0080. Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. PMID: 40929272; PMCID: PMC12422192.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. A vascular-associated fibroblastic cell controls pancreatic islet immunity. Cell Rep. 2025 Sep 23; 44(9):116189. Clarke D, Costanzo A, Sharma S, Kain L, Moremen KW, Pettus J, Domissy A, Wu P, Nguyen-Ngoc KV, Berti D, George SC, Hughes CCW, Sander M, Teyton L. PMID: 40884792; PMCID: PMC12539416.
      View in: PubMed   Mentions:    Fields:    
    4. The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation. J Clin Invest. 2025 Oct 01; 135(19). Wortham M, Ramms B, Zeng C, Benthuysen JR, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Lee ST, Ruthig VA, Wells KL, Auwerx J, Shirihai OS, Sander M. PMID: 40762838; PMCID: PMC12483614.
      View in: PubMed   Mentions:    Fields:    
    5. Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids. Dev Cell. 2025 Sep 22; 60(18):2455-2469.e7. Jun Y, Nguyen-Ngoc KV, Sai S, Bender RHF, Gong W, Kravets V, Zhu H, Hatch CJ, Schlichting M, Gaetani R, Mallick M, Hachey SJ, Christman KL, George SC, Hughes CCW, Sander M. PMID: 40412386; PMCID: PMC12353569.
      View in: PubMed   Mentions:    Fields:    
    6. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. bioRxiv. 2025 Mar 17. Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. PMID: 40027657; PMCID: PMC11870426.
      View in: PubMed   Mentions:
    7. Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression. bioRxiv. 2025 Mar 17. Melton R, Jimenez S, Elison W, Tucciarone L, Howell A, Wang G, Berti D, Beebe E, Miller M, Zeng C, McGrail C, VanderStel K, Korgaonkar K, Elgamal R, Mummey H, Chiou J, Griffin E, Kusmartseva I, Atkinson M, Preissl S, Theis FJ, Sander M, Gaulton KJ. PMID: 40027657; PMCID: PMC11870426.
      View in: PubMed   Mentions:
    8. The IsletTester Mouse: An Immunodeficient Model With Stable Hyperglycemia for the Study of Human Islets. Diabetes. 2025 Mar 01; 74(3):332-342. Waite EL, Tigue M, Yu M, Lahori D, Kelly K, May CL, Naji A, Roman J, Doliba N, Avrahami D, Nguyen-Ngoc KV, Sander M, Glaser B, Kaestner KH. PMID: 39571094; PMCID: PMC11842601.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Author Correction: Every islet matters: improving the impact of human islet research. Nat Metab. 2024 Jul; 6(7):1415. Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M. PMID: 38956323.
      View in: PubMed   Mentions: 1     Fields:    
    10. Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells. iScience. 2024 Jul 19; 27(7):110291. Zhou Z, Gong M, Pande A, Margineanu A, Lisewski U, Purfürst B, Zhu H, Liang L, Jia S, Froehler S, Zeng C, Kühnen P, Khodaverdi S, Krill W, Röpke T, Chen W, Raile K, Sander M, Izsvák Z. PMID: 39055936; PMCID: PMC11269803.
      View in: PubMed   Mentions: 2  
    11. EU-LIFE charter of independent life science research institutes. FEBS Lett. 2024 Apr; 598(7):719-724. Superti-Furga G, Agostinho M, Bury J, Cook S, Durinx C, Ender A, van Luenen H, Lund AH, Medema RH, Miaczynska M, Nickel D, Pelicci PG, Puisieux A, Ripatti S, Sander M, Schubeler D, Serrano L, Sommer T, Sonne-Hansen K, Tomancák P, Vives J, Vontas J, Bettencourt-Dias M. PMID: 38514456.
      View in: PubMed   Mentions:    Fields:    
    12. Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2. bioRxiv. 2024 Feb 28. Wortham M, Ramms B, Zeng C, Benthuysen JR, Sai S, Pollow DP, Liu F, Schlichting M, Harrington AR, Liu B, Prakash TP, Pirie EC, Zhu H, Baghdasarian S, Auwerx J, Shirihai OS, Sander M. PMID: 38464227; PMCID: PMC10925077.
      View in: PubMed   Mentions:
    13. A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction. Biofabrication. 2024 01 11; 16(2). Bender RHF, O'Donnell BT, Shergill B, Pham BQ, Tahmouresie S, Sanchez CN, Juat DJ, Hatch MMS, Shirure VS, Wortham M, Nguyen-Ngoc KV, Jun Y, Gaetani R, Christman KL, Teyton L, George SC, Sander M, Hughes CCW. PMID: 38128127; PMCID: PMC10782895.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    14. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Diabetes. 2023 Aug 01; 72(8):1173. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari AE, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. PMID: 37116182; PMCID: PMC10382644.
      View in: PubMed   Mentions:    Fields:    
    15. Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding. Cell Death Dis. 2023 07 05; 14(7):399. Urizar AI, Prause M, Ingerslev LR, Wortham M, Sui Y, Sander M, Williams K, Barrès R, Larsen MR, Christensen GL, Billestrup N. PMID: 37407581; PMCID: PMC10322916.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes. Nat Genet. 2023 06; 55(6):984-994. Wang G, Chiou J, Zeng C, Miller M, Matta I, Han JY, Kadakia N, Okino ML, Beebe E, Mallick M, Camunas-Soler J, Dos Santos T, Dai XQ, Ellis C, Hang Y, Kim SK, MacDonald PE, Kandeel FR, Preissl S, Gaulton KJ, Sander M. PMID: 37231096; PMCID: PMC10550816.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    17. Nutrient regulation of the islet epigenome controls adaptive insulin secretion. J Clin Invest. 2023 04 17; 133(8). Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. PMID: 36821378; PMCID: PMC10104905.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes. Dev Cell. 2023 05 08; 58(9):727-743.e11. Zhu H, Wang G, Nguyen-Ngoc KV, Kim D, Miller M, Goss G, Kovsky J, Harrington AR, Saunders DC, Hopkirk AL, Melton R, Powers AC, Preissl S, Spagnoli FM, Gaulton KJ, Sander M. PMID: 37040771; PMCID: PMC10175223.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    19. Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors. Cell Stem Cell. 2023 04 06; 30(4):488-497.e3. Magenheim J, Maestro MA, Sharon N, Herrera PL, Murtaugh LC, Kopp J, Sander M, Gu G, Melton DA, Ferrer J, Dor Y. PMID: 37028408.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    20. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes. 2023 04 01; 72(4):433-448. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. PMID: 36940317; PMCID: PMC10033248.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes. bioRxiv. 2023 Jan 02. Wang G, Chiou J, Zeng C, Miller M, Matta I, Han JY, Kadakia N, Okino ML, Beebe E, Mallick M, Camunas-Soler J, Dos Santos T, Dai XQ, Ellis C, Hang Y, Kim SK, MacDonald PE, Kandeel FR, Preissl S, Gaulton KJ, Sander M. PMID: 36711922; PMCID: PMC9881862.
      View in: PubMed   Mentions:
    22. Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity. Diabetes. 2022 12 01; 71(12):2513-2529. Ramms B, Pollow DP, Zhu H, Nora C, Harrington AR, Omar I, Gordts PLSM, Wortham M, Sander M. PMID: 36162056; PMCID: PMC9750949.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    23. Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines. Cell Genom. 2022 Dec 14; 2(12):100214. Benaglio P, Zhu H, Okino ML, Yan J, Elgamal R, Nariai N, Beebe E, Korgaonkar K, Qiu Y, Donovan MKR, Chiou J, Wang G, Newsome J, Kaur J, Miller M, Preissl S, Corban S, Aylward A, Taipale J, Ren B, Frazer KA, Sander M, Gaulton KJ. PMID: 36778047; PMCID: PMC9903835.
      View in: PubMed   Mentions: 18     Fields:    
    24. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Pancreas. 2022 10 01; 51(9):1061-1073. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Sander M, Pandol SJ. PMID: 37078927; PMCID: PMC10328394.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Every islet matters: improving the impact of human islet research. Nat Metab. 2022 08; 4(8):970-977. Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M. PMID: 35953581; PMCID: PMC11135339.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    26. Sizing up beta cells made from stem cells. Nat Biotechnol. 2022 07; 40(7):1006-1008. Nguyen-Ngoc KV, Wortham M, Sander M. PMID: 35288669.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    27. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet. 2022 05; 54(5):560-572. Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen ME, Jørgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schönherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stancáková A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W, FinnGen, eMERGE Consortium, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YI, Froguel P, Wilson JG, Sheu WHH, Kardia SLR, Wu JY, Hayes MG, Ma RCW, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Palmer CNA, Liu S, Abecasis G, Kooner JS, Loos RJF, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, Mägi R, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, et al. PMID: 35551307; PMCID: PMC9179018.
      View in: PubMed   Mentions: 339     Fields:    Translation:Humans
    28. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Care. 2022 01 01; 45(1):3-22. Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Symposium planning committee, moderators, and speakers. PMID: 34782355; PMCID: PMC8753760.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    29. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403. Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. PMID: 34823065; PMCID: PMC8689243.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    30. Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. Commun Biol. 2021 11 17; 4(1):1298. Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, Zhang X, Nair GG, Seufferlein T, Hebrok M, Sander M, Julier C, Kleger A, Costa IG. PMID: 34789845; PMCID: PMC8599846.
      View in: PubMed   Mentions: 16  Translation:HumansCells
    31. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors. Nat Commun. 2021 11 17; 12(1):6636. Geusz RJ, Wang A, Lam DK, Vinckier NK, Alysandratos KD, Roberts DA, Wang J, Kefalopoulou S, Ramirez A, Qiu Y, Chiou J, Gaulton KJ, Ren B, Kotton DN, Sander M. PMID: 34789735; PMCID: PMC8599738.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    32. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes. 2021 11 13. Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND, Symposium planning committee, moderators, and speakers:, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J. PMID: 34957490.
      View in: PubMed   Mentions: 3     Fields:    
    33. A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus. Nat Rev Endocrinol. 2021 11; 17(11):641-642. Wang G, Sander M. PMID: 34404938.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Mutations and variants of ONECUT1 in diabetes. Nat Med. 2021 11; 27(11):1928-1940. Philippi A, Heller S, Costa IG, Senée V, Breunig M, Li Z, Kwon G, Russell R, Illing A, Lin Q, Hohwieler M, Degavre A, Zalloua P, Liebau S, Schuster M, Krumm J, Zhang X, Geusz R, Benthuysen JR, Wang A, Chiou J, Gaulton K, Neubauer H, Simon E, Klein T, Wagner M, Nair G, Besse C, Dandine-Roulland C, Olaso R, Deleuze JF, Kuster B, Hebrok M, Seufferlein T, Sander M, Boehm BO, Oswald F, Nicolino M, Julier C, Kleger A. PMID: 34663987; PMCID: PMC9356324.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    35. What is a β cell? - Chapter I in the Human Islet Research Network (HIRN) review series. Mol Metab. 2021 11; 53:101323. Kaestner KH, Campbell-Thompson M, Dor Y, Gill RG, Glaser B, Kim SK, Sander M, Stabler C, Stewart AF, Powers AC. PMID: 34416394; PMCID: PMC8452767.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    36. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes. 2021 08 01; 70(8):1634-1637. Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. PMID: 35381060; PMCID: PMC8385609.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    37. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes Care. 2021 08; 44(8):1744-1747. Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. PMID: 34131046; PMCID: PMC8385471.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma. Sci Rep. 2021 06 03; 11(1):11823. Chen J, Debebe A, Zeng N, Kopp J, He L, Sander M, Stiles BL. PMID: 34083580; PMCID: PMC8175600.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    39. Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation. Trends Endocrinol Metab. 2021 07; 32(7):474-487. Wortham M, Sander M. PMID: 34030925; PMCID: PMC8259463.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    40. Interpreting type 1 diabetes risk with genetics and single-cell epigenomics. Nature. 2021 06; 594(7863):398-402. Chiou J, Geusz RJ, Okino ML, Han JY, Miller M, Melton R, Beebe E, Benaglio P, Huang S, Korgaonkar K, Heller S, Kleger A, Preissl S, Gorkin DU, Sander M, Gaulton KJ. PMID: 34012112; PMCID: PMC10560508.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansCells
    41. Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk. Nat Genet. 2021 04; 53(4):455-466. Chiou J, Zeng C, Cheng Z, Han JY, Schlichting M, Miller M, Mendez R, Huang S, Wang J, Sui Y, Deogaygay A, Okino ML, Qiu Y, Sun Y, Kudtarkar P, Fang R, Preissl S, Sander M, Gorkin DU, Gaulton KJ. PMID: 33795864; PMCID: PMC9037575.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    42. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. Elife. 2021 02 05; 10. Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDS, Gaulton KJ, Sander M. PMID: 33544077; PMCID: PMC7864636.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    43. Inferring time series chromatin states for promoter-enhancer pairs based on Hi-C data. BMC Genomics. 2021 Jan 28; 22(1):84. Miko H, Qiu Y, Gaertner B, Sander M, Ohler U. PMID: 33509077; PMCID: PMC7841892.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    44. Systematic analysis of binding of transcription factors to noncoding variants. Nature. 2021 03; 591(7848):147-151. Yan J, Qiu Y, Ribeiro Dos Santos AM, Yin Y, Li YE, Vinckier N, Nariai N, Benaglio P, Raman A, Li X, Fan S, Chiou J, Chen F, Frazer KA, Gaulton KJ, Sander M, Taipale J, Ren B. PMID: 33505025; PMCID: PMC9367673.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    45. A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation. Elife. 2020 08 03; 9. Gaertner B, van Heesch S, Schneider-Lunitz V, Schulz JF, Witte F, Blachut S, Nguyen S, Wong R, Matta I, Hübner N, Sander M. PMID: 32744504; PMCID: PMC7423336.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    46. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 04 29; 11(1):2082. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. PMID: 32350257; PMCID: PMC7190832.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    47. PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response. Cell Death Dis. 2020 03 16; 11(3):187. Ye J, Huang A, Wang H, Zhang AMY, Huang X, Lan Q, Sato T, Goyama S, Kurokawa M, Deng C, Sander M, Schaeffer DF, Li W, Kopp JL, Xie R. PMID: 32179733; PMCID: PMC7075911.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    48. In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids. Sci Adv. 2019 11; 5(11):eaax4520. Jun Y, Lee J, Choi S, Yang JH, Sander M, Chung S, Lee SH. PMID: 31807701; PMCID: PMC6881167.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    49. Human stem cell models: lessons for pancreatic development and disease. Genes Dev. 2019 11 01; 33(21-22):1475-1490. Gaertner B, Carrano AC, Sander M. PMID: 31676735; PMCID: PMC6824472.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    50. A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells. iScience. 2019 Nov 22; 21:681-694. Jin W, Mulas F, Gaertner B, Sui Y, Wang J, Matta I, Zeng C, Vinckier N, Wang A, Nguyen-Ngoc KV, Chiou J, Kaestner KH, Frazer KA, Carrano AC, Shih HP, Sander M. PMID: 31733514; PMCID: PMC6889369.
      View in: PubMed   Mentions: 17  
    51. Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications. Mol Cell Endocrinol. 2019 10 01; 496:110524. Ibarra Urizar A, Prause M, Wortham M, Sui Y, Thams P, Sander M, Christensen GL, Billestrup N. PMID: 31362031.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    52. Differential Cell Susceptibilities to KrasG12D in the Setting of Obstructive Chronic Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019; 8(4):579-594. Shi C, Pan FC, Kim JN, Washington MK, Padmanabhan C, Meyer CT, Kopp JL, Sander M, Gannon M, Beauchamp RD, Wright CV, Means AL. PMID: 31310834; PMCID: PMC6889613.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    53. Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk. Nat Commun. 2019 05 07; 10(1):2078. Greenwald WW, Chiou J, Yan J, Qiu Y, Dai N, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer KA, Sander M, Ren B, Gaulton KJ. PMID: 31064983; PMCID: PMC6505525.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    54. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875; PMCID: PMC6317899.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    55. Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Schöenbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. PMID: 30398401; PMCID: PMC6306687.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    56. N6-methyladenine DNA Modification in Glioblastoma. Cell. 2018 11 15; 175(5):1228-1243.e20. Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, Dowiak AV, Lin K, Zeng C, Sui Y, Kim LJY, Miller TE, Jiang L, Lee-Poturalski C, Huang Z, Fang X, Zhai K, Mack SC, Sander M, Bao S, Kerstetter-Fogle AE, Sloan AE, Xiao AZ, Rich JN. PMID: 30392959; PMCID: PMC6433469.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    57. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nat Cell Biol. 2018 11; 20(11):1267-1277. Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL. PMID: 30361701; PMCID: PMC6215453.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    58. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018 10; 67(10):1923-1931. Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak K. PMID: 30237160; PMCID: PMC6463748.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    59. Pancreatic Exocrine Tissue Architecture and Integrity are Maintained by E-cadherin During Postnatal Development. Sci Rep. 2018 09 07; 8(1):13451. Serrill JD, Sander M, Shih HP. PMID: 30194315; PMCID: PMC6128895.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    60. ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis. Dev Dyn. 2018 06; 247(6):854-866. Das KK, Heeg S, Pitarresi JR, Reichert M, Bakir B, Takano S, Kopp JL, Wahl-Feuerstein A, Hicks P, Sander M, Rustgi AK. PMID: 29532564; PMCID: PMC5980739.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    61. Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma. Gut. 2019 03; 68(3):487-498. Lee AYL, Dubois CL, Sarai K, Zarei S, Schaeffer DF, Sander M, Kopp JL. PMID: 29363536; PMCID: PMC11529381.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    62. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. PMID: 29273451; PMCID: PMC5880733.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    63. Interrogating islets in health and disease with single-cell technologies. Mol Metab. 2017 09; 6(9):991-1001. Carrano AC, Mulas F, Zeng C, Sander M. PMID: 28951823; PMCID: PMC5605723.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    64. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11. Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. PMID: 28467932; PMCID: PMC5501713.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    65. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest. 2017 01 03; 127(1):215-229. Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA. PMID: 27941246; PMCID: PMC5199701.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    66. Advances in β cell replacement and regeneration strategies for treating diabetes. J Clin Invest. 2016 10 03; 126(10):3651-3660. Benthuysen JR, Carrano AC, Sander M. PMID: 27694741; PMCID: PMC5096826.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    67. Mechanisms of β-cell functional adaptation to changes in workload. Diabetes Obes Metab. 2016 09; 18 Suppl 1:78-86. Wortham M, Sander M. PMID: 27615135; PMCID: PMC5021190.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    68. Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. Elife. 2016 06 21; 5. Barrionuevo FJ, Hurtado A, Kim GJ, Real FM, Bakkali M, Kopp JL, Sander M, Scherer G, Burgos M, Jiménez R. PMID: 27328324; PMCID: PMC4945155.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    69. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. PMID: 27281208; PMCID: PMC4998062.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    70. High T Gives β Cells a Boost. Cell Metab. 2016 May 10; 23(5):761-3. Wortham M, Sander M. PMID: 27166938.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    71. Stem cells versus plasticity in liver and pancreas regeneration. Nat Cell Biol. 2016 Mar; 18(3):238-45. Kopp JL, Grompe M, Sander M. PMID: 26911907.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    72. ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis. Cell Rep. 2016 Jan 12; 14(2):169-79. Shih HP, Panlasigui D, Cirulli V, Sander M. PMID: 26748698; PMCID: PMC4715768.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    73. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep. 2015 Oct 13; 13(2):326-36. Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M. PMID: 26440894; PMCID: PMC4607666.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    74. Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus. Development. 2015 Oct 01; 142(19):3416-28. Thélie A, Desiderio S, Hanotel J, Quigley I, Van Driessche B, Rodari A, Borromeo MD, Kricha S, Lahaye F, Croce J, Cerda-Moya G, Ordoño Fernandez J, Bolle B, Lewis KE, Sander M, Pierani A, Schubert M, Johnson JE, Kintner CR, Pieler T, Van Lint C, Henningfeld KA, Bellefroid EJ, Van Campenhout C. PMID: 26443638; PMCID: PMC4631751.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    75. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. PMID: 26276631; PMCID: PMC4545590.
      View in: PubMed   Mentions: 265     Fields:    Translation:AnimalsCells
    76. Lineage fate of ductular reactions in liver injury and carcinogenesis. J Clin Invest. 2015 Jun; 125(6):2445-57. Jörs S, Jeliazkova P, Ringelhan M, Thalhammer J, Dürl S, Ferrer J, Sander M, Heikenwalder M, Schmid RM, Siveke JT, Geisler F. PMID: 25915586; PMCID: PMC4497753.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    77. Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell. 2015 Apr 02; 16(4):386-99. Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, Sander M. PMID: 25842977; PMCID: PMC4478079.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansCells
    78. Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 01; 142(5):871-82. De Vas MG, Kopp JL, Heliot C, Sander M, Cereghini S, Haumaitre C. PMID: 25715395; PMCID: PMC4352981.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    79. A systems view of epigenetic networks regulating pancreas development and β-cell function. Wiley Interdiscip Rev Syst Biol Med. 2015 Jan-Feb; 7(1):1-11. Xie R, Carrano AC, Sander M. PMID: 25644779; PMCID: PMC4339621.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    80. The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells. BMC Dev Biol. 2014 Dec 20; 14:47. Malhotra GK, Zhao X, Edwards E, Kopp JL, Naramura M, Sander M, Band H, Band V. PMID: 25527186; PMCID: PMC4297388.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    81. Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. PLoS One. 2014; 9(10):e109171. Zhao X, Chen Y, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M. PMID: 25285789; PMCID: PMC4186865.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    82. Postnatal β-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1. Diabetes. 2015 Mar; 64(3):897-903. Taylor BL, Benthuysen J, Sander M. PMID: 25277396; PMCID: PMC4338594.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    83. Stem cell epigenetics: looking forward. Cell Stem Cell. 2014 Jun 05; 14(6):706-9. Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL. PMID: 25032261.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    84. Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor. J Am Soc Nephrol. 2014 Nov; 25(11):2584-95. Kanda S, Tanigawa S, Ohmori T, Taguchi A, Kudo K, Suzuki Y, Sato Y, Hino S, Sander M, Perantoni AO, Sugano S, Nakao M, Nishinakamura R. PMID: 24744442; PMCID: PMC4214521.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    85. Pancreas development ex vivo: culturing embryonic pancreas explants on permeable culture inserts, with fibronectin-coated glass microwells, or embedded in three-dimensional Matrigel™. Methods Mol Biol. 2014; 1210:229-37. Shih HP, Sander M. PMID: 25173172; PMCID: PMC4423897.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    86. New insights into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions? Gastroenterology. 2014 Jan; 146(1):24-6. Kopp JL, Sander M. PMID: 24275238.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    87. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4456-64. Rockich BE, Hrycaj SM, Shih HP, Nagy MS, Ferguson MA, Kopp JL, Sander M, Wellik DM, Spence JR. PMID: 24191021; PMCID: PMC3839746.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    88. Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep. 2013 Sep 26; 4(6):1262-75. Taylor BL, Liu FF, Sander M. PMID: 24035389; PMCID: PMC4058003.
      View in: PubMed   Mentions: 197     Fields:    Translation:AnimalsCells
    89. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol. 2013; 29:81-105. Shih HP, Wang A, Sander M. PMID: 23909279.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    90. Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest. 2013 Aug; 123(8):3305-16. Guo S, Dai C, Guo M, Taylor B, Harmon JS, Sander M, Robertson RP, Powers AC, Stein R. PMID: 23863625; PMCID: PMC3726150.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansAnimalsCells
    91. Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):3907-12. Jin L, Feng T, Shih HP, Zerda R, Luo A, Hsu J, Mahdavi A, Sander M, Tirrell DA, Riggs AD, Ku HT. PMID: 23431132; PMCID: PMC3593860.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    92. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013; 9(1):e1003274. Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. PMID: 23382704; PMCID: PMC3561089.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    93. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 2013 Feb 07; 12(2):224-37. Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M. PMID: 23318056; PMCID: PMC3619036.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    94. Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS One. 2012; 7(12):e52181. van der Meulen T, Xie R, Kelly OG, Vale WW, Sander M, Huising MO. PMID: 23251699; PMCID: PMC3522648.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    95. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Dec 11; 22(6):737-50. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. PMID: 23201164; PMCID: PMC3568632.
      View in: PubMed   Mentions: 392     Fields:    Translation:HumansCells
    96. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab. 2012 Oct 03; 16(4):435-48. Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakic N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J. PMID: 23040067; PMCID: PMC3475176.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansAnimalsCells
    97. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep; 139(18):3363-72. Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M. PMID: 22874919; PMCID: PMC3424044.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    98. Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells. J Mol Med (Berl). 2012 Jul; 90(7):763-71. Wang A, Sander M. PMID: 22714642.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    99. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development. 2012 Jul; 139(14):2488-99. Shih HP, Kopp JL, Sandhu M, Dubois CL, Seymour PA, Grapin-Botton A, Sander M. PMID: 22675211; PMCID: PMC3383226.
      View in: PubMed   Mentions: 117     Fields:    Translation:Animals
    100. Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance. Mol Endocrinol. 2011 Nov; 25(11):1904-14. Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M. PMID: 21964593; PMCID: PMC3198960.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    101. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One. 2011; 6(8):e23131. Dubois CL, Shih HP, Seymour PA, Patel NA, Behrmann JM, Ngo V, Sander M. PMID: 21829703; PMCID: PMC3149078.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    102. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology. 2011 Oct; 141(4):1432-8, 1438.e1-4. Carpentier R, Suñer RE, van Hul N, Kopp JL, Beaudry JB, Cordi S, Antoniou A, Raynaud P, Lepreux S, Jacquemin P, Leclercq IA, Sander M, Lemaigre FP. PMID: 21708104; PMCID: PMC3494970.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    103. Progenitor cell domains in the developing and adult pancreas. Cell Cycle. 2011 Jun 15; 10(12):1921-7. Kopp JL, Dubois CL, Hao E, Thorel F, Herrera PL, Sander M. PMID: 21558806; PMCID: PMC3154415.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    104. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev. 2011 Jun 01; 25(11):1193-203. Dorrell C, Erker L, Schug J, Kopp JL, Canaday PS, Fox AJ, Smirnova O, Duncan AW, Finegold MJ, Sander M, Kaestner KH, Grompe M. PMID: 21632826; PMCID: PMC3110957.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    105. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011 Feb; 138(4):653-65. Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M. PMID: 21266405; PMCID: PMC3026412.
      View in: PubMed   Mentions: 293     Fields:    Translation:AnimalsCells
    106. Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes. 2011 Feb; 60(2):364-76. Seymour PA, Sander M. PMID: 21270248; PMCID: PMC3028333.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    107. Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell. 2010 Jun 15; 18(6):1022-9. Schaffer AE, Freude KK, Nelson SB, Sander M. PMID: 20627083; PMCID: PMC3133668.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    108. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development. 2009 Aug; 136(15):2545-55. Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W. PMID: 19592574; PMCID: PMC2729334.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    109. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9715-20. Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G. PMID: 19487660; PMCID: PMC2701002.
      View in: PubMed   Mentions: 101     Fields:    Translation:Animals
    110. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol. 2008 Nov 01; 323(1):19-30. Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M. PMID: 18723011; PMCID: PMC2879081.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    111. Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15; 318(2):224-35. Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M. PMID: 18452912; PMCID: PMC2478757.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    112. The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development. 2007 Jul; 134(13):2491-500. Nelson SB, Schaffer AE, Sander M. PMID: 17537793.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    113. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1865-70. Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M. PMID: 17267606; PMCID: PMC1794281.
      View in: PubMed   Mentions: 303     Fields:    Translation:AnimalsCells
    114. Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections. Methods Mol Biol. 2007; 411:13-23. Seymour PA, Sander M. PMID: 18287635.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    115. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol. 2005 Dec 15; 288(2):487-501. Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P, Beta Cell Biology Consortium. PMID: 16297379.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    116. NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development. 2005 Jul; 132(13):3139-49. Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M. PMID: 15944193.
      View in: PubMed   Mentions: 104     Fields:    Translation:Animals
    117. Expression of Nkx6 genes in the hindbrain and gut of the developing mouse. J Histochem Cytochem. 2005 Jun; 53(6):787-90. Nelson SB, Janiesch C, Sander M. PMID: 15928328.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    118. Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron. 2005 Jan 06; 45(1):41-53. Cai J, Qi Y, Hu X, Tan M, Liu Z, Zhang J, Li Q, Sander M, Qiu M. PMID: 15629701.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    119. Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice. Mol Endocrinol. 2004 Nov; 18(11):2765-76. Mellitzer G, Martín M, Sidhoum-Jenny M, Orvain C, Barths J, Seymour PA, Sander M, Gradwohl G. PMID: 15297605.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    120. The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2930-3. Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R. PMID: 14973194; PMCID: PMC365722.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    121. Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development. 2003 Dec; 130(25):6221-31. Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M. PMID: 14602683.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    122. Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons. Development. 2003 Dec; 130(23):5815-26. Müller M, Jabs N, Lorke DE, Fritzsch B, Sander M. PMID: 14534138.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    123. Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development. 2003 Sep; 130(17):4149-59. Pattyn A, Vallstedt A, Dias JM, Sander M, Ericson J. PMID: 12874134.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    124. Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul; 227(3):402-8. Lioubinski O, Müller M, Wegner M, Sander M. PMID: 12815626.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
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