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Maike Sander

Title(s)Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0695
La Jolla CA 92093
Phone8/2-46--0843
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    Collapse Overview 
    Collapse Overview
    Our laboratory studies the molecular mechanisms that underlie the differentiation, function and regeneration of cells in the pancreas. We investigate these mechanisms in the context of normal physiology, diabetes and cancer. In our research, we combine of variety experimental systems, including mouse genetics, a human embryonic stem cell-based in vitro differentiation platform, as well as genomic and biochemical approaches.
    In recent studies, we mapped dynamic changes in the transcriptome and epigenome during the progression of pluripotent stem cells toward the pancreatic fate and discovered how chromatin remodeling events prepare developmental precursors to receive and correctly interpret organ-inductive signals. In current work, we are exploring how the cellular environment shapes the epigenome and thereby influences cellular phenotypes in the pancreas. Such knowledge will likely yield an understanding of the mechanisms underlying diseases influenced by both environmental and genetic factors, such as diabetes.

    Research Focus Areas:

  • Developmental Biology

  • Genetics and Genomics

  • Gene Expression and Regulation

  • Stem Cell Biology


  • Collapse Research 
    Collapse Research Activities and Funding
    A 3D vascularized islet biomimetic to model type 1 diabetes
    NIH/NIDDK UG3DK122639Aug 1, 2019 - Jul 31, 2024
    Role: Principal Investigator
    Genetic mechanisms of type 1 diabetes risk in stress-induced pancreatic islets
    NIH/NIDDK R01DK122607Aug 1, 2019 - May 31, 2023
    Role: Co-Principal Investigator
    Pancreatic Diseases Gordon Research Conference
    NIH/NIDDK R13DK121395Mar 1, 2019 - Feb 29, 2020
    Role: Principal Investigator
    Single cell analysis of the human pancreas in type 1 diabetes
    NIH/NIDDK U01DK120429Sep 25, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Promotion of beta cell proliferation by epigenetically reprogrammed macrophages
    NIH/NIDDK R01DK114427Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Fine-mapping and functional analysis of T1D-associated variants
    NIH/NIDDK DP3DK112155Sep 30, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Functional Analysis of T2D Associated Non-coding SNPs
    NIH/NIDDK U01DK105541May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    A novel mouse model to identify biomarkers of IPMN formation and progression
    NIH/NCI R21CA194839Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    A 3-D biomimetic human islet to model beta cell function in health and disease
    NIH/NIDDK UC4DK104202Sep 20, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Epigenetic strategies for the in vitro generation of replacement beta cells
    NIH/NIDDK U01DK089567Sep 17, 2010 - Jun 30, 2014
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Aug 13, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Novel insights into nutrient-dependent regulation of beta cell proliferation
    NIH/NIDDK R01DK078803Sep 1, 2007 - Sep 30, 2008
    Role: Principal Investigator
    Epigenetic determinants of beta cell development and function
    NIH/NIDDK R01DK068471Jun 1, 2004 - May 31, 2009
    Role: Principal Investigator
    Diabetes Research Center (DRC)
    NIH/NIDDK P30DK063491Dec 1, 2002 - Nov 30, 2007
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation. Elife. 2020 08 03; 9. Gaertner B, van Heesch S, Schneider-Lunitz V, Schulz JF, Witte F, Blachut S, Nguyen S, Wong R, Matta I, Hübner N, Sander M. PMID: 32744504.
      View in: PubMed   Mentions:    Fields:    
    2. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 04 29; 11(1):2082. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. PMID: 32350257.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids. Sci Adv. 2019 11; 5(11):eaax4520. Jun Y, Lee J, Choi S, Yang JH, Sander M, Chung S, Lee SH. PMID: 31807701.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Human stem cell models: lessons for pancreatic development and disease. Genes Dev. 2019 11 01; 33(21-22):1475-1490. Gaertner B, Carrano AC, Sander M. PMID: 31676735.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells. iScience. 2019 Nov 22; 21:681-694. Jin W, Mulas F, Gaertner B, Sui Y, Wang J, Matta I, Zeng C, Vinckier N, Wang A, Nguyen-Ngoc KV, Chiou J, Kaestner KH, Frazer KA, Carrano AC, Shih HP, Sander M. PMID: 31733514.
      View in: PubMed   Mentions:
    6. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic ß Cell Function. Cell Rep. 2018 12 04; 25(10):2904-2918.e8. Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. PMID: 30517875.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Schöenbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. PMID: 30398401.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. N6-methyladenine DNA Modification in Glioblastoma. Cell. 2018 11 15; 175(5):1228-1243.e20. Xie Q, Wu TP, Gimple RC, Li Z, Prager BC, Wu Q, Yu Y, Wang P, Wang Y, Gorkin DU, Zhang C, Dowiak AV, Lin K, Zeng C, Sui Y, Kim LJY, Miller TE, Jiang L, Lee CH, Huang Z, Fang X, Zhai K, Mack SC, Sander M, Bao S, Kerstetter-Fogle AE, Sloan AE, Xiao AZ, Rich JN. PMID: 30392959.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    9. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. PMID: 29273451.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Interrogating islets in health and disease with single-cell technologies. Mol Metab. 2017 09; 6(9):991-1001. Carrano AC, Mulas F, Zeng C, Sander M. PMID: 28951823.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11. Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. PMID: 28467932.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    12. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. PMID: 27281208.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    13. High T Gives ß Cells a Boost. Cell Metab. 2016 May 10; 23(5):761-3. Wortham M, Sander M. PMID: 27166938.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis. Cell Rep. 2016 Jan 12; 14(2):169-79. Shih HP, Panlasigui D, Cirulli V, Sander M. PMID: 26748698.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    15. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell Rep. 2015 Oct 13; 13(2):326-36. Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M. PMID: 26440894.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. PMID: 26276631.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    17. Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell. 2015 Apr 02; 16(4):386-99. Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, Sander M. PMID: 25842977.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    18. A systems view of epigenetic networks regulating pancreas development and ß-cell function. Wiley Interdiscip Rev Syst Biol Med. 2015 Jan-Feb; 7(1):1-11. Xie R, Carrano AC, Sander M. PMID: 25644779.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Postnatal ß-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1. Diabetes. 2015 Mar; 64(3):897-903. Taylor BL, Benthuysen J, Sander M. PMID: 25277396.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    20. Pancreas development ex vivo: culturing embryonic pancreas explants on permeable culture inserts, with fibronectin-coated glass microwells, or embedded in three-dimensional Matrigel™. Methods Mol Biol. 2014; 1210:229-37. Shih HP, Sander M. PMID: 25173172.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    21. New insights into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions? Gastroenterology. 2014 Jan; 146(1):24-6. Kopp JL, Sander M. PMID: 24275238.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep. 2013 Sep 26; 4(6):1262-75. Taylor BL, Liu FF, Sander M. PMID: 24035389.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    23. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol. 2013; 29:81-105. Shih HP, Wang A, Sander M. PMID: 23909279.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    24. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013; 9(1):e1003274. Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. PMID: 23382704.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    25. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 2013 Feb 07; 12(2):224-37. Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M. PMID: 23318056.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    26. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Dec 11; 22(6):737-50. Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. PMID: 23201164.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansCells
    27. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep; 139(18):3363-72. Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M. PMID: 22874919.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    28. Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells. J Mol Med (Berl). 2012 Jul; 90(7):763-71. Wang A, Sander M. PMID: 22714642.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development. 2012 Jul; 139(14):2488-99. Shih HP, Kopp JL, Sandhu M, Dubois CL, Seymour PA, Grapin-Botton A, Sander M. PMID: 22675211.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    30. Transgenic overexpression of the transcription factor Nkx6.1 in ß-cells of mice does not increase ß-cell proliferation, ß-cell mass, or improve glucose clearance. Mol Endocrinol. 2011 Nov; 25(11):1904-14. Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M. PMID: 21964593.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    31. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One. 2011; 6(8):e23131. Dubois CL, Shih HP, Seymour PA, Patel NA, Behrmann JM, Ngo V, Sander M. PMID: 21829703.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    32. Progenitor cell domains in the developing and adult pancreas. . 2011 Jun 15; 10(12):1921-7. Kopp JL, Dubois CL, Hao E, Thorel F, Herrera PL, Sander M. PMID: 21558806.
      View in: PubMed   Mentions:
    33. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011 Feb; 138(4):653-65. Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M. PMID: 21266405.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    34. Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes. 2011 Feb; 60(2):364-76. Seymour PA, Sander M. PMID: 21270248.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    35. Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell. 2010 Jun 15; 18(6):1022-9. Schaffer AE, Freude KK, Nelson SB, Sander M. PMID: 20627083.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
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