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Veronica Shubayev

TitleProfessor In Residence
InstitutionUniversity of California San Diego
DepartmentAnesthesiology
Address9500 Gilman Drive #0629
La Jolla CA 92093
Phone858-534-5278
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    Collapse Research 
    Collapse Research Activities and Funding
    Proteolysis of Myelin as a Source of Neuropathic Pain
    NIH/NIDCR R01DE022757Jul 30, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Pathogenesis of Nerve Injury: Role of Matrix Metalloproteinases
    VA I01BX000638Oct 1, 2009 - Dec 31, 2018
    Role: Principal Investigator
    Neurotoxicity of Magnetic Nanoparticles
    NIH/NIEHS R21ES015871Jul 1, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Matrix metalloproteinases as biomarkers of neurodegeneration
    NIH/NINDS R21NS060307Aug 15, 2007 - Jun 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Remacle AG, Hullugundi SK, Dolkas J, Angert M, Cieplak P, Scott D, Chernov AV, Shubayev V, Strongin AY. Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism. Biochem J. 2018 Jun 28. PMID: 29954845.
      View in: PubMed
    2. Shubayev V, Zochodne DW. Robert R. Myers: In Memoriam (April 15, 1946-April 19, 2018). J Peripher Nerv Syst. 2018 May 25. PMID: 29799146.
      View in: PubMed
    3. Remacle AG, Hullugundi SK, Dolkas J, Angert M, Chernov AV, Strongin AY, Shubayev V. Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury. J Neuroinflammation. 2018 Mar 20; 15(1):89. PMID: 29558999.
      View in: PubMed
    4. Remacle AG, Dolkas J, Angert M, Hullugundi SK, Chernov AV, Jones RCW, Shubayev V, Strongin AY. A sensitive and selective ELISA methodology quantifies a demyelination marker in experimental and clinical samples. J Immunol Methods. 2018 Apr; 455:80-87. PMID: 29428829.
      View in: PubMed
    5. Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev V. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. Brain Behav Immun. 2017 Feb; 60:282-292. PMID: 27833045.
      View in: PubMed
    6. Eddinger KA, Rondon ES, Shubayev V, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. 2016 08; 125(2):378-94. PMID: 27272672.
      View in: PubMed
    7. Mo AH, Zhang C, Landon PB, Janetanakit W, Hwang MT, Santacruz Gomez K, Colburn DA, Dossou SM, Lu T, Cao Y, Sant V, Sud PL, Akkiraju S, Shubayev V, Glinsky G, Lal R. Dual-Functionalized Theranostic Nanocarriers. ACS Appl Mater Interfaces. 2016 Jun 15; 8(23):14740-6. PMID: 27144808.
      View in: PubMed
    8. Shubayev V, Strongin AY, Yaksh TL. Role of myelin auto-antigens in pain: a female connection. Neural Regen Res. 2016 Jun; 11(6):890-1. PMID: 27482203; PMCID: PMC4962572.
    9. Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev V. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain Behav Immun. 2016 Aug; 56:378-89. PMID: 26970355; PMCID: PMC4917441 [Available on 08/01/17].
    10. He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dan Dumitru C, Lettieri K, Shubayev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL. Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature. 2016 Apr 21; 532(7599):402. PMID: 26789244.
      View in: PubMed
    11. He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dumitru CD, Lettieri K, Shubayev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature. 2015 Oct 29; 526(7575):710-4. PMID: 26503042; PMCID: PMC4754353.
    12. Liu H, Dolkas J, Hoang K, Angert M, Chernov AV, Remacle AG, Shiryaev SA, Strongin AY, Nishihara T, Shubayev V. The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury. J Neuroinflammation. 2015 Sep 04; 12:158. PMID: 26337825; PMCID: PMC4559385.
    13. Remacle AG, Kumar S, Motamedchaboki K, Cieplak P, Hullugundi S, Dolkas J, Shubayev V, Strongin AY. Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling. J Biol Chem. 2015 Sep 18; 290(38):22939-44. PMID: 26283785; PMCID: PMC4645627.
    14. Liu H, Angert M, Nishihara T, Shubayev I, Dolkas J, Shubayev V. Spinal Glia Division Contributes to Conditioning Lesion-Induced Axon Regeneration Into the Injured Spinal Cord: Potential Role of Cyclic AMP-Induced Tissue Inhibitor of Metalloproteinase-1. J Neuropathol Exp Neurol. 2015 Jun; 74(6):500-11. PMID: 25933384; PMCID: PMC4469649.
    15. Chernov AV, Dolkas J, Hoang K, Angert M, Srikrishna G, Vogl T, Baranovskaya S, Strongin AY, Shubayev V. The calcium-binding proteins S100A8 and S100A9 initiate the early inflammatory program in injured peripheral nerves. J Biol Chem. 2015 May 01; 290(18):11771-84. PMID: 25792748; PMCID: PMC4416877.
    16. Nishihara T, Remacle AG, Angert M, Shubayev I, Shiryaev SA, Liu H, Dolkas J, Chernov AV, Strongin AY, Shubayev V. Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury. J Biol Chem. 2015 Feb 06; 290(6):3693-707. PMID: 25488667; PMCID: PMC4319034.
    17. Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-60. PMID: 24631588; PMCID: PMC4128246.
    18. VanSchoiack LR, Shubayev V, Myers RR, Sheets CG, Earthman JC. In vivo evaluation of quantitative percussion diagnostics for determining implant stability. Int J Oral Maxillofac Implants. 2013 Sep-Oct; 28(5):1286-92. PMID: 24066319; PMCID: PMC4039658.
    19. Hamurtekin E, Fitzsimmons BL, Shubayev V, Grafe MR, Deumens R, Yaksh TL, Walker SM. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 2013 Jul; 119(1):142-55. PMID: 23514721; PMCID: PMC3732172.
    20. Kim Y, Kong SD, Chen LH, Pisanic TR, Jin S, Shubayev V. In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms. Nanomedicine. 2013 Oct; 9(7):1057-66. PMID: 23669369; PMCID: PMC3783535.
    21. Kong SD, Lee J, Ramachandran S, Eliceiri BP, Shubayev V, Lal R, Jin S. Magnetic targeting of nanoparticles across the intact blood-brain barrier. J Control Release. 2012 Nov 28; 164(1):49-57. PMID: 23063548; PMCID: PMC4440873.
    22. Liu H, Shiryaev SA, Chernov AV, Kim Y, Shubayev I, Remacle AG, Baranovskaya S, Golubkov VS, Strongin AY, Shubayev V. Immunodominant fragments of myelin basic protein initiate T cell-dependent pain. J Neuroinflammation. 2012 Jun 07; 9:119. PMID: 22676642; PMCID: PMC3416717.
    23. Kim Y, Remacle AG, Chernov AV, Liu H, Shubayev I, Lai C, Dolkas J, Shiryaev SA, Golubkov VS, Mizisin AP, Strongin AY, Shubayev V. The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration. PLoS One. 2012; 7(3):e33664. PMID: 22438979; PMCID: PMC3306282.
    24. Xu Q, Chou B, Fitzsimmons B, Miyanohara A, Shubayev V, Santucci C, Hefferan M, Marsala M, Hua XY. In vivo gene knockdown in rat dorsal root ganglia mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery. PLoS One. 2012; 7(3):e32581. PMID: 22403675; PMCID: PMC3293818.
    25. Myers RR, Shubayev V. The ology of neuropathy: an integrative review of the role of neuroinflammation and TNF-a axonal transport in neuropathic pain. J Peripher Nerv Syst. 2011 Dec; 16(4):277-86. PMID: 22176142; PMCID: PMC4444223.
    26. Liu H, Shubayev V. Matrix metalloproteinase-9 controls proliferation of NG2+ progenitor cells immediately after spinal cord injury. Exp Neurol. 2011 Oct; 231(2):236-46. PMID: 21756907; PMCID: PMC3171631.
    27. Liu H, Kim Y, Chattopadhyay S, Shubayev I, Dolkas J, Shubayev V. Matrix metalloproteinase inhibition enhances the rate of nerve regeneration in vivo by promoting dedifferentiation and mitosis of supporting schwann cells. J Neuropathol Exp Neurol. 2010 Apr; 69(4):386-95. PMID: 20448483; PMCID: PMC2866025.
    28. Kato K, Liu H, Kikuchi S, Myers RR, Shubayev V. Immediate anti-tumor necrosis factor-alpha (etanercept) therapy enhances axonal regeneration after sciatic nerve crush. J Neurosci Res. 2010 Feb 01; 88(2):360-8. PMID: 19746434; PMCID: PMC4479282.
    29. Chattopadhyay S, Shubayev V. MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway. Glia. 2009 Sep; 57(12):1316-25. PMID: 19229995; PMCID: PMC2713381.
    30. Shubayev V, Pisanic TR, Jin S. Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev. 2009 Jun 21; 61(6):467-77. PMID: 19389434; PMCID: PMC2700776.
    31. Kobayashi H, Chattopadhyay S, Kato K, Dolkas J, Kikuchi S, Myers RR, Shubayev V. MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage. Mol Cell Neurosci. 2008 Dec; 39(4):619-27. PMID: 18817874; PMCID: PMC2865888.
    32. Teles RM, Antunes SL, Jardim MR, Oliveira AL, Nery JA, Sales AM, Sampaio EP, Shubayev V, Sarno EN. Expression of metalloproteinases (MMP-2, MMP-9, and TACE) and TNF-alpha in the nerves of leprosy patients. J Peripher Nerv Syst. 2007 Sep; 12(3):195-204. PMID: 17868246.
      View in: PubMed
    33. Pisanic TR, Blackwell JD, Shubayev V, Fiñones RR, Jin S. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials. 2007 Jun; 28(16):2572-81. PMID: 17320946.
      View in: PubMed
    34. Chattopadhyay S, Myers RR, Janes J, Shubayev V. Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve. Brain Behav Immun. 2007 Jul; 21(5):561-8. PMID: 17189680; PMCID: PMC2865892.
    35. Takahashi N, Kikuchi S, Shubayev V, Campana WM, Myers RR. TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica. Spine (Phila Pa 1976). 2006 Mar 01; 31(5):523-9. PMID: 16508545.
      View in: PubMed
    36. Campana WM, Li X, Shubayev V, Angert M, Cai K, Myers RR. Erythropoietin reduces Schwann cell TNF-alpha, Wallerian degeneration and pain-related behaviors after peripheral nerve injury. Eur J Neurosci. 2006 Feb; 23(3):617-26. PMID: 16487143.
      View in: PubMed
    37. Myers RR, Campana WM, Shubayev V. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov Today. 2006 Jan; 11(1-2):8-20. PMID: 16478686.
      View in: PubMed
    38. Shubayev V, Angert M, Dolkas J, Campana WM, Palenscar K, Myers RR. TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci. 2006 Mar; 31(3):407-15. PMID: 16297636; PMCID: PMC4431648.
    39. Shubayev V, Brånemark R, Steinauer J, Myers RR. Titanium implants induce expression of matrix metalloproteinases in bone during osseointegration. J Rehabil Res Dev. 2004 Nov-Dec; 41(6A):757-66. PMID: 15685464.
      View in: PubMed
    40. Shubayev V, Myers RR. Matrix metalloproteinase-9 promotes nerve growth factor-induced neurite elongation but not new sprout formation in vitro. J Neurosci Res. 2004 Jul 15; 77(2):229-39. PMID: 15211589.
      View in: PubMed
    41. Shubayev V, Myers RR. Anterograde TNF alpha transport from rat dorsal root ganglion to spinal cord and injured sciatic nerve. Neurosci Lett. 2002 Mar 01; 320(1-2):99-101. PMID: 11849773.
      View in: PubMed
    42. Shubayev V, Myers RR. Endoneurial remodeling by TNFalph- and TNFalpha-releasing proteases. A spatial and temporal co-localization study in painful neuropathy. J Peripher Nerv Syst. 2002 Mar; 7(1):28-36. PMID: 11939349.
      View in: PubMed
    43. Shubayev V, Myers RR. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. J Neuroimmunol. 2001 Mar 01; 114(1-2):48-56. PMID: 11240015.
      View in: PubMed
    44. Igarashi T, Kikuchi S, Shubayev V, Myers RR. 2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine (Phila Pa 1976). 2000 Dec 01; 25(23):2975-80. PMID: 11145807.
      View in: PubMed
    45. Shubayev V, Myers RR. Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury. Brain Res. 2000 Feb 07; 855(1):83-9. PMID: 10650133.
      View in: PubMed
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