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    Veronica Shubayev

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentAnesthesiology
    Address9500 Gilman Drive #0629
    CA La Jolla 92093
    Phone858-534-5278
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      Collapse Research 
      Collapse Research Activities and Funding
      Proteolysis of Myelin as a Source of Neuropathic Pain
      NIH/NIDCR R01DE022757Jul 30, 2012 - Jun 30, 2017
      Role: Principal Investigator
      Pathogenesis of Nerve Injury: Role of Matrix Metalloproteinases
      VA I01BX000638Oct 1, 2009 - Dec 31, 2018
      Role: Principal Investigator
      Neurotoxicity of Magnetic Nanoparticles
      NIH/NIEHS R21ES015871Jul 1, 2009 - Jun 30, 2012
      Role: Principal Investigator
      Matrix metalloproteinases as biomarkers of neurodegeneration
      NIH/NINDS R21NS060307Aug 15, 2007 - Jun 30, 2010
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi S, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev V. Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. Brain Behav Immun. 2016 Nov 7. PMID: 27833045.
        View in: PubMed
      2. Eddinger KA, Rondon ES, Shubayev V, Grafe MR, Scadeng M, Hildebrand KR, Page LM, Malkmus SA, Steinauer JJ, Yaksh TL. Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation. Anesthesiology. 2016 Aug; 125(2):378-94. PMID: 27272672.
        View in: PubMed
      3. Mo AH, Zhang C, Landon PB, Janetanakit W, Hwang MT, Santacruz Gomez K, Colburn DA, Dossou SM, Lu T, Cao Y, Sant V, Sud PL, Akkiraju S, Shubayev V, Glinsky G, Lal R. Dual-Functionalized Theranostic Nanocarriers. ACS Appl Mater Interfaces. 2016 Jun 15; 8(23):14740-6. PMID: 27144808.
        View in: PubMed
      4. Shubayev V, Strongin AY, Yaksh TL. Role of myelin auto-antigens in pain: a female connection. Neural Regen Res. 2016 Jun; 11(6):890-1. PMID: 27482203.
        View in: PubMed
      5. Ko JS, Eddinger KA, Angert M, Chernov AV, Dolkas J, Strongin AY, Yaksh TL, Shubayev V. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain Behav Immun. 2016 Aug; 56:378-89. PMID: 26970355.
        View in: PubMed
      6. He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dan Dumitru C, Lettieri K, Shubayev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL. Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature. 2016 Apr 21; 532(7599):402. PMID: 26789244.
        View in: PubMed
      7. He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dumitru CD, Lettieri K, Shubayev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature. 2015 Oct 29; 526(7575):710-4. PMID: 26503042.
        View in: PubMed
      8. Liu H, Dolkas J, Hoang K, Angert M, Chernov AV, Remacle AG, Shiryaev SA, Strongin AY, Nishihara T, Shubayev V. The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury. J Neuroinflammation. 2015; 12(1):158. PMID: 26337825.
        View in: PubMed
      9. Remacle AG, Kumar S, Motamedchaboki K, Cieplak P, Hullugundi S, Dolkas J, Shubayev V, Strongin AY. Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling. J Biol Chem. 2015 Sep 18; 290(38):22939-44. PMID: 26283785.
        View in: PubMed
      10. Liu H, Angert M, Nishihara T, Shubayev I, Dolkas J, Shubayev V. Spinal Glia Division Contributes to Conditioning Lesion-Induced Axon Regeneration Into the Injured Spinal Cord: Potential Role of Cyclic AMP-Induced Tissue Inhibitor of Metalloproteinase-1. J Neuropathol Exp Neurol. 2015 Jun; 74(6):500-11. PMID: 25933384.
        View in: PubMed
      11. Chernov AV, Dolkas J, Hoang K, Angert M, Srikrishna G, Vogl T, Baranovskaya S, Strongin AY, Shubayev V. The Calcium-binding Proteins S100A8 and S100A9 Initiate the Early Inflammatory Program in Injured Peripheral Nerves. J Biol Chem. 2015 May 1; 290(18):11771-84. PMID: 25792748.
        View in: PubMed
      12. Nishihara T, Remacle AG, Angert M, Shubayev I, Shiryaev SA, Liu H, Dolkas J, Chernov AV, Strongin AY, Shubayev V. Matrix Metalloproteinase-14 Both Sheds Cell Surface Neuronal Glial Antigen 2 (NG2) Proteoglycan on Macrophages and Governs the Response to Peripheral Nerve Injury. J Biol Chem. 2015 Feb 6; 290(6):3693-707. PMID: 25488667.
        View in: PubMed
      13. Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: Potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-60. PMID: 24631588.
        View in: PubMed
      14. VanSchoiack LR, Shubayev V, Myers RR, Sheets CG, Earthman JC. In vivo evaluation of quantitative percussion diagnostics for determining implant stability. Int J Oral Maxillofac Implants. 2013 Sep-Oct; 28(5):1286-92. PMID: 24066319.
        View in: PubMed
      15. Hamurtekin E, Fitzsimmons BL, Shubayev V, Grafe MR, Deumens R, Yaksh TL, Walker SM. Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat. Anesthesiology. 2013 Jul; 119(1):142-55. PMID: 23514721.
        View in: PubMed
      16. Kim Y, Kong SD, Chen LH, Pisanic TR, Jin S, Shubayev V. In vivo nanoneurotoxicity screening using oxidative stress and neuroinflammation paradigms. Nanomedicine. 2013 Oct; 9(7):1057-66. PMID: 23669369.
        View in: PubMed
      17. Kong SD, Lee J, Ramachandran S, Eliceiri BP, Shubayev V, Lal R, Jin S. Magnetic targeting of nanoparticles across the intact blood-brain barrier. J Control Release. 2012 Nov 28; 164(1):49-57. PMID: 23063548.
        View in: PubMed
      18. Liu H, Shiryaev SA, Chernov AV, Kim Y, Shubayev I, Remacle AG, Baranovskaya S, Golubkov VS, Strongin AY, Shubayev V. Immunodominant fragments of myelin basic protein initiate T cell-dependent pain. J Neuroinflammation. 2012; 9:119. PMID: 22676642.
        View in: PubMed
      19. Kim Y, Remacle AG, Chernov AV, Liu H, Shubayev I, Lai C, Dolkas J, Shiryaev SA, Golubkov VS, Mizisin AP, Strongin AY, Shubayev V. The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration. PLoS One. 2012; 7(3):e33664. PMID: 22438979.
        View in: PubMed
      20. Xu Q, Chou B, Fitzsimmons B, Miyanohara A, Shubayev V, Santucci C, Hefferan M, Marsala M, Hua XY. In vivo gene knockdown in rat dorsal root ganglia mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery. PLoS One. 2012; 7(3):e32581. PMID: 22403675.
        View in: PubMed
      21. Myers RR, Shubayev V. The ology of neuropathy: an integrative review of the role of neuroinflammation and TNF-a axonal transport in neuropathic pain. J Peripher Nerv Syst. 2011 Dec; 16(4):277-86. PMID: 22176142.
        View in: PubMed
      22. Liu H, Shubayev V. Matrix metalloproteinase-9 controls proliferation of NG2+ progenitor cells immediately after spinal cord injury. Exp Neurol. 2011 Oct; 231(2):236-46. PMID: 21756907.
        View in: PubMed
      23. Liu H, Kim Y, Chattopadhyay S, Shubayev I, Dolkas J, Shubayev V. Matrix metalloproteinase inhibition enhances the rate of nerve regeneration in vivo by promoting dedifferentiation and mitosis of supporting schwann cells. J Neuropathol Exp Neurol. 2010 Apr; 69(4):386-95. PMID: 20448483.
        View in: PubMed
      24. Kato K, Liu H, Kikuchi S, Myers RR, Shubayev V. Immediate anti-tumor necrosis factor-alpha (etanercept) therapy enhances axonal regeneration after sciatic nerve crush. J Neurosci Res. 2010 Feb 1; 88(2):360-8. PMID: 19746434.
        View in: PubMed
      25. Chattopadhyay S, Shubayev V. MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway. Glia. 2009 Sep; 57(12):1316-25. PMID: 19229995.
        View in: PubMed
      26. Shubayev V, Pisanic TR, Jin S. Magnetic nanoparticles for theragnostics. Adv Drug Deliv Rev. 2009 Jun 21; 61(6):467-77. PMID: 19389434.
        View in: PubMed
      27. Kato K, Kikuchi S, Shubayev V, Myers RR. Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered etanercept into injured and uninjured rat sciatic nerve. Neuroscience. 2009 May 5; 160(2):492-500. PMID: 19250961.
        View in: PubMed
      28. Kobayashi H, Chattopadhyay S, Kato K, Dolkas J, Kikuchi S, Myers RR, Shubayev V. MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage. Mol Cell Neurosci. 2008 Dec; 39(4):619-27. PMID: 18817874.
        View in: PubMed
      29. Teles RM, Antunes SL, Jardim MR, Oliveira AL, Nery JA, Sales AM, Sampaio EP, Shubayev V, Sarno EN. Expression of metalloproteinases (MMP-2, MMP-9, and TACE) and TNF-alpha in the nerves of leprosy patients. J Peripher Nerv Syst. 2007 Sep; 12(3):195-204. PMID: 17868246.
        View in: PubMed
      30. Pisanic TR, Blackwell JD, Shubayev V, Fiñones RR, Jin S. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials. 2007 Jun; 28(16):2572-81. PMID: 17320946.
        View in: PubMed
      31. Chattopadhyay S, Myers RR, Janes J, Shubayev V. Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve. Brain Behav Immun. 2007 Jul; 21(5):561-8. PMID: 17189680.
        View in: PubMed
      32. Takahashi N, Kikuchi S, Shubayev V, Campana WM, Myers RR. TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica. Spine (Phila Pa 1976). 2006 Mar 1; 31(5):523-9. PMID: 16508545.
        View in: PubMed
      33. Campana WM, Li X, Shubayev V, Angert M, Cai K, Myers RR. Erythropoietin reduces Schwann cell TNF-alpha, Wallerian degeneration and pain-related behaviors after peripheral nerve injury. Eur J Neurosci. 2006 Feb; 23(3):617-26. PMID: 16487143.
        View in: PubMed
      34. Myers RR, Campana WM, Shubayev V. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov Today. 2006 Jan; 11(1-2):8-20. PMID: 16478686.
        View in: PubMed
      35. Shubayev V, Angert M, Dolkas J, Campana WM, Palenscar K, Myers RR. TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci. 2006 Mar; 31(3):407-15. PMID: 16297636.
        View in: PubMed
      36. Shubayev V, Brånemark R, Steinauer J, Myers RR. Titanium implants induce expression of matrix metalloproteinases in bone during osseointegration. J Rehabil Res Dev. 2004 Nov-Dec; 41(6A):757-66. PMID: 15685464.
        View in: PubMed
      37. Shubayev V, Myers RR. Matrix metalloproteinase-9 promotes nerve growth factor-induced neurite elongation but not new sprout formation in vitro. J Neurosci Res. 2004 Jul 15; 77(2):229-39. PMID: 15211589.
        View in: PubMed
      38. Schäfers M, Sorkin LS, Geis C, Shubayev V. Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat. Neurosci Lett. 2003 Aug 28; 347(3):179-82. PMID: 12875915.
        View in: PubMed
      39. Shubayev V, Myers RR. Anterograde TNF alpha transport from rat dorsal root ganglion to spinal cord and injured sciatic nerve. Neurosci Lett. 2002 Mar 1; 320(1-2):99-101. PMID: 11849773.
        View in: PubMed
      40. Shubayev V, Myers RR. Endoneurial remodeling by TNFalph- and TNFalpha-releasing proteases. A spatial and temporal co-localization study in painful neuropathy. J Peripher Nerv Syst. 2002 Mar; 7(1):28-36. PMID: 11939349.
        View in: PubMed
      41. Shubayev V, Myers RR. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. J Neuroimmunol. 2001 Mar 1; 114(1-2):48-56. PMID: 11240015.
        View in: PubMed
      42. Igarashi T, Kikuchi S, Shubayev V, Myers RR. 2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine (Phila Pa 1976). 2000 Dec 1; 25(23):2975-80. PMID: 11145807.
        View in: PubMed
      43. Shubayev V, Myers RR. Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury. Brain Res. 2000 Feb 7; 855(1):83-9. PMID: 10650133.
        View in: PubMed
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