Wolfgang Wrasidlo

Title(s)Recall Non-faculty Academic, Radiation Medicine and Applied Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD. Sci Transl Med. 2023 05 10; 15(695):eabq6089. Iba M, Kim C, Kwon S, Szabo M, Horan-Portelance L, Peer CJ, Figg WD, Reed X, Ding J, Lee SJ, Rissman RA, Cookson MR, Overk C, Wrasidlo W, Masliah E. PMID: 37163617.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    2. NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation. Int J Inflam. 2022; 2022:2337363. Habas A, Reddy Natala S, Bowden-Verhoek JK, Stocking EM, Price DL, Wrasidlo W, Bonhaus DW, Gill MB. PMID: 35265316; PMCID: PMC8898874.
      View in: PubMed   Mentions: 3  
    3. NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease. Brain. 2021 12 31; 144(12):3692-3709. Khan A, Johnson R, Wittmer C, Maile M, Tatsukawa K, Wong JL, Gill MB, Stocking EM, Natala SR, Paulino AD, Bowden-Verhoek JK, Wrasidlo W, Masliah E, Bonhaus DW, Price DL. PMID: 34117864.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    4. Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists. Bioorg Med Chem Lett. 2021 05 15; 40:127861. Natala SR, Habas A, Stocking EM, Orry A, Price DL, Gill MB, Bonhaus DW, Abagyan R, Wrasidlo W. PMID: 33636302.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease. Sci Rep. 2018 11 01; 8(1):16165. Price DL, Koike MA, Khan A, Wrasidlo W, Rockenstein E, Masliah E, Bonhaus D. PMID: 30385782; PMCID: PMC6212487.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    6. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7813-7818. Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B. PMID: 29991596; PMCID: PMC6065020.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    7. Optimized Scintillator YAG:Pr Nanoparticles for X-ray Inducible Photodynamic Therapy. Mater Lett. 2018 Oct 01; 228:49-52. Sapre AA, Novitskaya E, Vakharia V, Cota A, Wrasidlo W, Hanrahan SM, Derenzo S, Makale MT, Graeve OA. PMID: 30505045; PMCID: PMC6258075.
      View in: PubMed   Mentions: 1  
    8. Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):E3679-E3688. Kouroupi G, Taoufik E, Vlachos IS, Tsioras K, Antoniou N, Papastefanaki F, Chroni-Tzartou D, Wrasidlo W, Bohl D, Stellas D, Politis PK, Vekrellis K, Papadimitriou D, Stefanis L, Bregestovski P, Hatzigeorgiou AG, Masliah E, Matsas R. PMID: 28416701; PMCID: PMC5422768.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    9. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 04; 8(14):22370-22384. Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S. PMID: 26517684; PMCID: PMC5410230.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303. Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. PMID: 28105557; PMCID: PMC5729903.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236. Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481; PMCID: PMC5840882.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimals
    12. Small molecule NPT-440-1 inhibits ionic flux through Aβ1-42 pores: Implications for Alzheimer's disease therapeutics. Nanomedicine. 2016 11; 12(8):2331-2340. Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R. PMID: 27335341; PMCID: PMC5116404.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236. Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. PMID: 26683203; PMCID: PMC4683943.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    14. Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023; PMCID: PMC4944825.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    15. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73. Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211; PMCID: PMC4290715.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    16. Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease. Neurobiol Dis. 2015 Feb; 74:144-57. Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA. PMID: 25173807; PMCID: PMC4323687.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600. Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640; PMCID: PMC4449729.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    18. High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. Int J Nanomedicine. 2013; 8:3991-4006. Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S. PMID: 24174874; PMCID: PMC3808212.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. IMD-0354 targets breast cancer stem cells: a novel approach for an adjuvant to chemotherapy to prevent multidrug resistance in a murine model. PLoS One. 2013; 8(8):e73607. Gomez-Cabrero A, Wrasidlo W, Reisfeld RA. PMID: 24014113; PMCID: PMC3754963.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    20. Extraction protocol and mass spectrometry method for quantification of doxorubicin released locally from prodrugs in tumor tissue. J Mass Spectrom. 2013 Jul; 48(7):768-73. Ibsen S, Su Y, Norton J, Zahavy E, Hayashi T, Adams S, Wrasidlo W, Esener S. PMID: 23832932; PMCID: PMC4110111.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    21. Localized in vivo activation of a photoactivatable doxorubicin prodrug in deep tumor tissue. Photochem Photobiol. 2013 May-Jun; 89(3):698-708. Ibsen S, Zahavy E, Wrasidlo W, Hayashi T, Norton J, Su Y, Adams S, Esener S. PMID: 23311544; PMCID: PMC4072807.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains. Bioconjug Chem. 2012 May 16; 23(5):1003-9. Chao Y, Makale M, Karmali PP, Sharikov Y, Tsigelny I, Merkulov S, Kesari S, Wrasidlo W, Ruoslahti E, Simberg D. PMID: 22515422; PMCID: PMC3444675.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    23. Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13. Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. PMID: 22251432; PMCID: PMC3925782.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    24. Assembly and targeting of liposomal nanoparticles encapsulating quantum dots. Bioconjug Chem. 2011 Aug 17; 22(8):1638-44. Mukthavaram R, Wrasidlo W, Hall D, Kesari S, Makale M. PMID: 21786821; PMCID: PMC3160765.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    25. Targeted therapeutic remodeling of the tumor microenvironment improves an HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model. Cancer Res. 2011 Sep 01; 71(17):5688-96. Liao D, Liu Z, Wrasidlo WJ, Luo Y, Nguyen G, Chen T, Xiang R, Reisfeld RA. PMID: 21784871.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    26. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. PMID: 21665146; PMCID: PMC3144144.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimals
    27. Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity. Nanomedicine. 2011 Dec; 7(6):665-73. Liao D, Liu Z, Wrasidlo W, Chen T, Luo Y, Xiang R, Reisfeld RA. PMID: 21419870.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    28. Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010 Sep 01; 6:742-7. Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. PMID: 20978615; PMCID: PMC2956464.
      View in: PubMed   Mentions:
    29. Magnetic resonance and fluorescence imaging of doxorubicin-loaded nanoparticles using a novel in vivo model. Nanomedicine. 2010 Dec; 6(6):797-807. Erten A, Wrasidlo W, Scadeng M, Esener S, Hoffman RM, Bouvet M, Makale M. PMID: 20599526; PMCID: PMC2980586.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304. Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. PMID: 20154271; PMCID: PMC2840076.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    31. Eradication of CD19+ leukemia by targeted calicheamicin θ. Bioconjug Chem. 2009 Aug 19; 20(8):1587-94. Bernt KM, Prokop A, Huebener N, Gaedicke G, Wrasidlo W, Lode HN. PMID: 19572629.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    32. Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200. Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson DA. PMID: 19445505; PMCID: PMC2976567.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    33. Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clin Cancer Res. 2009 Jan 15; 15(2):553-60. Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB. PMID: 19147760; PMCID: PMC2707998.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    34. Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2009 Mar; 328(3):758-65. Doukas J, Eide L, Stebbins K, Racanelli-Layton A, Dellamary L, Martin M, Dneprovskaia E, Noronha G, Soll R, Wrasidlo W, Acevedo LM, Cheresh DA. PMID: 19056934.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    35. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9343-8. Murphy EA, Majeti BK, Barnes LA, Makale M, Weis SM, Lutu-Fuga K, Wrasidlo W, Cheresh DA. PMID: 18607000; PMCID: PMC2453735.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    36. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8. Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. PMID: 18268346; PMCID: PMC2268133.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    37. Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J Med Chem. 2007 Sep 06; 50(18):4279-94. Palanki MS, Dneprovskaia E, Doukas J, Fine RM, Hood J, Kang X, Lohse D, Martin M, Noronha G, Soll RM, Wrasidlo W, Yee S, Zhu H. PMID: 17685602.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19866-71. Doukas J, Wrasidlo W, Noronha G, Dneprovskaia E, Fine R, Weis S, Hood J, Demaria A, Soll R, Cheresh D. PMID: 17172449; PMCID: PMC1702529.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    39. Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorg Med Chem Lett. 2006 Nov 01; 16(21):5546-50. Noronha G, Barrett K, Cao J, Dneprovskaia E, Fine R, Gong X, Gritzen C, Hood J, Kang X, Klebansky B, Li G, Liao W, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Soll R, Splittgerber U, Wrasidlo W, Zeng B, Zhao N, Zhou Y. PMID: 16931012.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia. Blood. 2003 Jul 01; 102(1):246-53. Schroeder U, Bernt KM, Lange B, Wenkel J, Jikai J, Shabat D, Amir R, Huebener N, Niethammer AG, Hagemeier C, Wiebusch L, Gaedicke G, Wrasidlo W, Reisfeld RA, Lode HN. PMID: 12623853.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    41. Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation. Bioorg Med Chem. 2002 Sep; 10(9):3023-9. Satchi-Fainaro R, Wrasidlo W, Lode HN, Shabat D. PMID: 12110325.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    42. A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjug Chem. 2002 Sep-Oct; 13(5):1093-9. Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld RA, Lode HN. PMID: 12236791.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
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