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Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD. Sci Transl Med. 2023 05 10; 15(695):eabq6089.
Iba M, Kim C, Kwon S, Szabo M, Horan-Portelance L, Peer CJ, Figg WD, Reed X, Ding J, Lee SJ, Rissman RA, Cookson MR, Overk C, Wrasidlo W, Masliah E. PMID: 37163617.
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PubMed Mentions:
4 Fields:
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HumansAnimalsCells
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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation. Int J Inflam. 2022; 2022:2337363.
Habas A, Reddy Natala S, Bowden-Verhoek JK, Stocking EM, Price DL, Wrasidlo W, Bonhaus DW, Gill MB. PMID: 35265316; PMCID: PMC8898874.
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3
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NPT520-34 improves neuropathology and motor deficits in a transgenic mouse model of Parkinson's disease. Brain. 2021 12 31; 144(12):3692-3709.
Khan A, Johnson R, Wittmer C, Maile M, Tatsukawa K, Wong JL, Gill MB, Stocking EM, Natala SR, Paulino AD, Bowden-Verhoek JK, Wrasidlo W, Masliah E, Bonhaus DW, Price DL. PMID: 34117864.
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PubMed Mentions:
9 Fields:
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HumansAnimals
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Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists. Bioorg Med Chem Lett. 2021 05 15; 40:127861.
Natala SR, Habas A, Stocking EM, Orry A, Price DL, Gill MB, Bonhaus DW, Abagyan R, Wrasidlo W. PMID: 33636302.
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4 Fields:
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HumansCells
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The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease. Sci Rep. 2018 11 01; 8(1):16165.
Price DL, Koike MA, Khan A, Wrasidlo W, Rockenstein E, Masliah E, Bonhaus D. PMID: 30385782; PMCID: PMC6212487.
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73 Fields:
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HumansAnimalsCells
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α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7813-7818.
Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B. PMID: 29991596; PMCID: PMC6065020.
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109 Fields:
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HumansCells
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Optimized Scintillator YAG:Pr Nanoparticles for X-ray Inducible Photodynamic Therapy. Mater Lett. 2018 Oct 01; 228:49-52.
Sapre AA, Novitskaya E, Vakharia V, Cota A, Wrasidlo W, Hanrahan SM, Derenzo S, Makale MT, Graeve OA. PMID: 30505045; PMCID: PMC6258075.
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2
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Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):E3679-E3688.
Kouroupi G, Taoufik E, Vlachos IS, Tsioras K, Antoniou N, Papastefanaki F, Chroni-Tzartou D, Wrasidlo W, Bohl D, Stellas D, Politis PK, Vekrellis K, Papadimitriou D, Stefanis L, Bregestovski P, Hatzigeorgiou AG, Masliah E, Matsas R. PMID: 28416701; PMCID: PMC5422768.
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PubMed Mentions:
77 Fields:
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HumansCells
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Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 04; 8(14):22370-22384.
Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S. PMID: 26517684; PMCID: PMC5410230.
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13 Fields:
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HumansAnimalsCells
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The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017 04; 23(2):290-303.
Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. PMID: 28105557; PMCID: PMC5729903.
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PubMed Mentions:
11 Fields:
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HumansAnimalsCells
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A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain. 2016 12; 139(Pt 12):3217-3236.
Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, Trejo-Morales M, Overk CR, Winter S, Zhu C, Chesselet MF, Meier D, Moessler H, Konrat R, Masliah E. PMID: 27679481; PMCID: PMC5840882.
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PubMed Mentions:
77 Fields:
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HumansAnimals
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Small molecule NPT-440-1 inhibits ionic flux through Aβ1-42 pores: Implications for Alzheimer's disease therapeutics. Nanomedicine. 2016 11; 12(8):2331-2340.
Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R. PMID: 27335341; PMCID: PMC5116404.
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Animals
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Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015 Dec 18; 12:236.
Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. PMID: 26683203; PMCID: PMC4683943.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions. ACS Chem Neurosci. 2015 Mar 18; 6(3):403-16.
Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Overk C, Gonzalez T, Trejo M, Spencer B, Kosberg K, Masliah E. PMID: 25561023; PMCID: PMC4944825.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. Br J Pharmacol. 2014 Dec; 171(24):5757-73.
Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. PMID: 25117211; PMCID: PMC4290715.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease. Neurobiol Dis. 2015 Feb; 74:144-57.
Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA. PMID: 25173807; PMCID: PMC4323687.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. J Alzheimers Dis. 2014; 39(3):583-600.
Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. PMID: 24240640; PMCID: PMC4449729.
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PubMed Mentions:
17 Fields:
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HumansAnimalsCells
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High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. Int J Nanomedicine. 2013; 8:3991-4006.
Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S. PMID: 24174874; PMCID: PMC3808212.
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PubMed Mentions:
15 Fields:
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HumansAnimalsCells
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IMD-0354 targets breast cancer stem cells: a novel approach for an adjuvant to chemotherapy to prevent multidrug resistance in a murine model. PLoS One. 2013; 8(8):e73607.
Gomez-Cabrero A, Wrasidlo W, Reisfeld RA. PMID: 24014113; PMCID: PMC3754963.
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PubMed Mentions:
29 Fields:
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HumansAnimalsCells
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Extraction protocol and mass spectrometry method for quantification of doxorubicin released locally from prodrugs in tumor tissue. J Mass Spectrom. 2013 Jul; 48(7):768-73.
Ibsen S, Su Y, Norton J, Zahavy E, Hayashi T, Adams S, Wrasidlo W, Esener S. PMID: 23832932; PMCID: PMC4110111.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Localized in vivo activation of a photoactivatable doxorubicin prodrug in deep tumor tissue. Photochem Photobiol. 2013 May-Jun; 89(3):698-708.
Ibsen S, Zahavy E, Wrasidlo W, Hayashi T, Norton J, Su Y, Adams S, Esener S. PMID: 23311544; PMCID: PMC4072807.
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PubMed Mentions:
10 Fields:
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HumansAnimalsCells
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Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains. Bioconjug Chem. 2012 May 16; 23(5):1003-9.
Chao Y, Makale M, Karmali PP, Sharikov Y, Tsigelny I, Merkulov S, Kesari S, Wrasidlo W, Ruoslahti E, Simberg D. PMID: 22515422; PMCID: PMC3444675.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS J. 2012 Mar; 279(6):1000-13.
Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. PMID: 22251432; PMCID: PMC3925782.
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PubMed Mentions:
84 Fields:
Translation:
AnimalsCells
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Assembly and targeting of liposomal nanoparticles encapsulating quantum dots. Bioconjug Chem. 2011 Aug 17; 22(8):1638-44.
Mukthavaram R, Wrasidlo W, Hall D, Kesari S, Makale M. PMID: 21786821; PMCID: PMC3160765.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Targeted therapeutic remodeling of the tumor microenvironment improves an HER-2 DNA vaccine and prevents recurrence in a murine breast cancer model. Cancer Res. 2011 Sep 01; 71(17):5688-96.
Liao D, Liu Z, Wrasidlo WJ, Luo Y, Nguyen G, Chen T, Xiang R, Reisfeld RA. PMID: 21784871.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27.
Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. PMID: 21665146; PMCID: PMC3144144.
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PubMed Mentions:
201 Fields:
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HumansAnimals
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Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity. Nanomedicine. 2011 Dec; 7(6):665-73.
Liao D, Liu Z, Wrasidlo W, Chen T, Luo Y, Xiang R, Reisfeld RA. PMID: 21419870.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid. Beilstein J Org Chem. 2010 Sep 01; 6:742-7.
Zhang Y, Elliot G, Saldanha A, Tsigelny I, Carson D, Wrasidlo W. PMID: 20978615; PMCID: PMC2956464.
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PubMed Mentions:
19 Fields:
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HumansAnimalsCells
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Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4299-304.
Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA. PMID: 20154271; PMCID: PMC2840076.
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PubMed Mentions:
25 Fields:
Translation:
Animals
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Eradication of CD19+ leukemia by targeted calicheamicin θ. Bioconjug Chem. 2009 Aug 19; 20(8):1587-94.
Bernt KM, Prokop A, Huebener N, Gaedicke G, Wrasidlo W, Lode HN. PMID: 19572629.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem. 2009 Jun; 20(6):1194-200.
Chan M, Hayashi T, Kuy CS, Gray CS, Wu CC, Corr M, Wrasidlo W, Cottam HB, Carson DA. PMID: 19445505; PMCID: PMC2976567.
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PubMed Mentions:
57 Fields:
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HumansAnimalsCells
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Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clin Cancer Res. 2009 Jan 15; 15(2):553-60.
Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB. PMID: 19147760; PMCID: PMC2707998.
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PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
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Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2009 Mar; 328(3):758-65.
Doukas J, Eide L, Stebbins K, Racanelli-Layton A, Dellamary L, Martin M, Dneprovskaia E, Noronha G, Soll R, Wrasidlo W, Acevedo LM, Cheresh DA. PMID: 19056934.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9343-8.
Murphy EA, Majeti BK, Barnes LA, Makale M, Weis SM, Lutu-Fuga K, Wrasidlo W, Cheresh DA. PMID: 18607000; PMCID: PMC2453735.
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PubMed Mentions:
142 Fields:
Translation:
AnimalsCells
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The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2313-8.
Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. PMID: 18268346; PMCID: PMC2268133.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J Med Chem. 2007 Sep 06; 50(18):4279-94.
Palanki MS, Dneprovskaia E, Doukas J, Fine RM, Hood J, Kang X, Lohse D, Martin M, Noronha G, Soll RM, Wrasidlo W, Yee S, Zhu H. PMID: 17685602.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19866-71.
Doukas J, Wrasidlo W, Noronha G, Dneprovskaia E, Fine R, Weis S, Hood J, Demaria A, Soll R, Cheresh D. PMID: 17172449; PMCID: PMC1702529.
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PubMed Mentions:
46 Fields:
Translation:
HumansAnimalsCells
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Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorg Med Chem Lett. 2006 Nov 01; 16(21):5546-50.
Noronha G, Barrett K, Cao J, Dneprovskaia E, Fine R, Gong X, Gritzen C, Hood J, Kang X, Klebansky B, Li G, Liao W, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Soll R, Splittgerber U, Wrasidlo W, Zeng B, Zhao N, Zhou Y. PMID: 16931012.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia. Blood. 2003 Jul 01; 102(1):246-53.
Schroeder U, Bernt KM, Lange B, Wenkel J, Jikai J, Shabat D, Amir R, Huebener N, Niethammer AG, Hagemeier C, Wiebusch L, Gaedicke G, Wrasidlo W, Reisfeld RA, Lode HN. PMID: 12623853.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation. Bioorg Med Chem. 2002 Sep; 10(9):3023-9.
Satchi-Fainaro R, Wrasidlo W, Lode HN, Shabat D. PMID: 12110325.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjug Chem. 2002 Sep-Oct; 13(5):1093-9.
Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld RA, Lode HN. PMID: 12236791.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells